POPULARITY
3 episodes with herpes simplex virus
2 episodes with herpes simplex virus
2 episodes with herpes simplex virus
2 episodes with herpes simplex virus
3 episodes with herpes simplex virus
2 episodes with herpes simplex virus
2 episodes with herpes simplex virus
TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer's disease. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Repetitive injury, herpes, and Alzheimers (Sci Signal) The tau of herpesvirus (TWiV 1187) Fishing for viruses in senile (TWiV 519) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv
To have your question featured in a future video, please email: questions@drmdc.health
Theralase Technologies CEO Roger DuMoulin-White joined Steve Darling from Proactive to share its lead drug formulation, Ruvidar, has shown significant preclinical effectiveness in destroying the Herpes Simplex Virus 1 (HSV-1), surpassing the current standard of care, Acyclovir. Acyclovir, widely used to manage HSV-1, does not cure the virus but helps to alleviate symptoms associated with herpes infections, such as cold sores, genital herpes, shingles, and chicken pox. DuMoulin-White highlighted that the global antiviral drug market is projected to reach around $71 billion by 2032, with approximately 3.7 billion people under age 50 infected with HSV-1. The preclinical findings indicate that Ruvidar is not only more potent than Acyclovir but also capable of preventing HSV-1 replication by an impressive 10 million-fold if administered one day post-infection—something Acyclovir fails to achieve. These promising results position Ruvidar as a potential game-changer in the treatment of HSV-1, offering hope for more effective management of this widespread virus. #proactiveinvestors #theralasetechnologiesinc #tsxv #tlt #otcqb #tftff #MedicalResearch #HealthcareInnovation #PatientCare #CancerResearch #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews #proactiveinvestors #theralasetechnologiesinc #tsxv #tlt #otcqb #tftff #MedicalResearch #HealthcareInnovation #PatientCare #CancerResearch #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews #Ruvidar #Acyclovir #Pharmaceuticals #Biotech #Oncology #ViralInfections #DrugDevelopment #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews
Welcome to The Veterans Disability Nexus, where we provide unique insights and expertise on medical evidence related to VA-rated disabilities.Leah Bucholz, a US Army Veteran, Physician Assistant, & former Compensation & Pension Examiner shares her knowledge related to Independent Medical Opinions often referred to as “Nexus Letters” in support of your pursuit of VA Disability every Wednesday at 7 AM.In the video, Leab discusses the connection between Herpes Simplex Virus (HSV) and PTSD in the context of VA disability claims. She explains that HSV, a common virus causing painful blisters, is often embarrassing for many, including veterans, and encourages those affected to seek medical advice or legal assistance for related VA claims. Highlighting the physiological link, she notes that stress, including emotional stress from conditions like PTSD, can activate the virus. She also references several sources, including the World Health Organization and CDC, to underscore the recurrent nature of HSV, its triggers, and the impact of stress on outbreaks.
Viral vectors are a cornerstone of gene therapy and many employ experts in the viral vector services space to help design and produce their specialty vectors. These service providers are experts at making sure you get the vector you want with a titer and purity you need for your application. We're joined in this episode by Dr. Cliff Froelich, Head of Analytical Development for a viral vector services provider. Cliff and his team work with AAV, lentivirus, and other vectors to support multiple, and simultaneous, client projects. Specifically, we dive into how they use various analytical and molecular methods to monitor and assess identity, strength, purity, impurities, potency, efficiency, empty/full ratios, safety, and more. As you might expect, it's not a one-method-does-it-all approach or solution. Yes, digital PCR is in the mix here, and Cliff does a great job of outlining where it shines relative to the other methods they use regularly in their GMP practice. In our career corner portion, you'll hear about Cliff's circuitous career path, which includes stints in the poultry industry and time as a clinical dietitian. Through it all, and into his current role, Cliff brings a passion and genuine interest for the science and its potential to affect lives. Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.
Why is it that women are almost twice as likely to develop Alzheimer's disease, and what are the greatest risk factors associated with developing dementia? Today on SHE MD, Mary Alice and Dr. Aliabadi team up with Dr. Kellyann Niotis to explore what women can do to prevent cognitive decline.Dr. Kellyann Niotis is one of the world's only preventative neurologists, specializing in personalized risk reduction for neurodegenerative disorders such as Alzheimer's disease, Lewy Body Dementia, and Parkinson's disease.In this episode, Dr. Niotis delves into known contributors to dementia and outlines her non-negotiable principles for maintaining brain health. Dr. Niotis walks our hosts through the way hormone fluctuations during menopause play a role in neurodegeneration and the critical health markers that signal red flags for neurologists. A strong advocate of the idea that "your genes are not your destiny," Dr. Niotis offers a wealth of research-backed advice and preventative measures to combat brain disease.Dr. Niotis highlights specific risks associated with the APOE4 gene and addresses common questions about brain disease, hormone replacement therapy, alcohol consumption, over-the-counter sleep aids, and even the role of the Herpes Simplex Virus in neuroinflammation. Tune in for the essential tools women need to protect themselves against cognitive decline.What if you could do more to understand your risk of breast cancer? Go to https://myriad.ws/getmyrisk to help identify cancer risks and empower your provider to take action for your health.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dr. Justin Abbatemarco and Dr. Alice Tang discuss herpes simplex virus encephalitis in patients with autoimmune conditions and other factors. Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000209297 This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.
Dr. Justin Abbatemarco talks with Dr. Alice Tang about the association between immune status and herpes simplex virus encephalitis. Read the related article in Neurology. This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.
Have you ever heard of Andrographis? Most people haven't, and it's time that changed! On this episode of Vitality Radio, Jared invites Cheryl Myers back to the show to dig deep on the clinically proven benefits of Andrographis - everything from helping with fatty liver, preventing and reducing the length of a cold, and its role with auto-immune disease. Next, they'll break down why CuraMed is the most powerful form of curcumin on the market and how it can help with inflammation, oxidative stress, and detoxification. You'll learn how and when to use these medicinal herbs and why they should be in your medicine cabinet.Cheryl Myers is Chief of Scientific Affairs for EuroPharma, Inc. She is an author and healthcare professional with certifications in cancer, pain control, and issues of aging. She is an expert in dietary supplements and natural medicines who has been a featured guest on hundreds of radio and television shows, as well as interviews with the New York Times, Prevention Magazine, the Wall Street Journal.Products:Terry Naturally AndrographisTerry Naturally CuramedAdditional Information:#325: Boswellia's Incredible Impact on Lung and Gut Inflammation, and the Powerhouse Antioxidant that is Grape Seed Extract, with Cheryl Myers#176 Natural Ways to Address Pain and Systemic Inflammation with Cheryl MyersVisit the podcast website here: VitalityRadio.comYou can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Please also join us on the Dearly Discarded Podcast with Jared St. Clair.Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
Physician Assistant and prior C&P examiner Leah Bucholz discusses about Herpes Simplex Virus (HSV) and VA Disability.Leah discusses the implications of herpes simplex virus (HSV) with VA disability. She explains that herpes, a common and transmittable disease, can be service-connected if it is shown to be related to military service. Veterans may be eligible for service connection for HSV if diagnosed during service (primary service connection) or if it's linked to another service-connected disability, such as PTSD from combat or sexual assault. Leah highlights the differences between HSV-1 (typically oral herpes) and HSV-2 (usually genital herpes), noting the increasing instances of crossover between the two. She mentions how stress, including that from PTSD, can aggravate herpes outbreaks, referencing various studies and resources like the CDC and WHO.
In this episode, we review the high-yield topic of Herpes Simplex Virus (HSV) from the Pediatrics section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets
Ginkgo biloba, known for its distinctive fan-shaped leaves, has been used in traditional medicine for centuries, particularly in Asia. Ginkgo biloba is often touted as an herb for brain health, such as improving memory and cognition. This reputation does a great disservice to the most versatile herb in the world. Ginkgo biloba can be used as a potent antiviral agent for a variety of viruses. Ginkgo biloba has some key bioactive antiviral components: Flavonoids and Terpenoids: Ginkgo leaves contain high levels of flavonoids and terpenoids, compounds known for their antioxidant properties. These substances contribute to the antiviral activity of the plant. Ginkgolides and Bilobalides: These are unique terpene trilactones found in Ginkgo biloba, which have specific antiviral activities. Ginkgo Biloba's Mechanisms of Antiviral Action The antiviral properties of Ginkgo biloba are multi-faceted, involving multiple mechanisms: Inhibition of the fusions and synthesis of proteins in the viruses herpes simplex 1 and 2 (HSV-1 and HSV-2). Inhibition of genome replication in cytomegalovirus (HCMV) and Zika virus (ZIKV). Inhibition of viral fusion proteins in HIV, Ebola virus (EBOV), influenza A virus (IAV), and Epstein-Barr virus (EBV). Inhibition of the targeting protein and DNA of coronoviruses (SARS-CoV-2), varicella zoster virus (VZV), and measles virus. Inhibition of Viral Entry and Replication: Some studies suggest that Ginkgo biloba extracts can interfere with the ability of viruses to enter host cells or replicate. This is a key step in preventing the spread of viral infections. Immune System Modulation: Ginkgo biloba might enhance the body's immune response against viral infections. By modulating immune functions, it could help in controlling viral spread and severity. Anti-inflammatory Effects: The anti-inflammatory properties of Ginkgo biloba can be beneficial in reducing the severity of symptoms associated with viral infections. Research on Ginkgo Biloba's Antiviral Properties Anti-MERS-CoV and Anti-HCoV-229E Properties: A study focused on the antiviral activities of Ginkgo biloba leaf extracts against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Human Coronavirus 229E (HCoV-229E). Inhibition of Enveloped Viruses: Research published in Scientific Reports discussed how ginkgolic acid, a component of Ginkgo biloba, inhibits the fusion of enveloped viruses. The study found that ginkgolic acid had a strong inhibitory effect on Human Cytomegalovirus (HCMV) and also tested its effects on Herpes Simplex Virus-1 (HSV-1) and Zika Virus (ZIKV). Researchers also found broad spectrum inhibition by ginkgolic acid of all three classes of fusion proteins including HIV, Ebola virus (EBOV), influenza A virus (IAV) and Epstein Barr virus (EBV). In addition, inhibition was found of a non-enveloped adenovirus. The authors conclude that ginkolic acids may potentially be used to treat acute infections (e.g. Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g. HSV-1, HSV-2 and varicella-zoster virus (VZV)). It was observed that ginkgolic acid could inhibit the entry of these viruses into cells, thereby blocking viral replication. Another study entitled, “Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay” found that ginkgolic acids from ginkgo biloba inhibited the SARS-CoV-2 virus from binding to the ACE2 receptor and thus could potentially be helpful in acute COVID-19 infections. I use VascuSelect from Moss Nutrition which contains 120 mg of ginkgo biloba, 100 mg of grape seed extract, and 100 mg of mango fruit powder per capsule for acute and chronic viruses dosed 1 capsule once or twice a day with or without food. Grape seed extract and mango fruit powder have also been shown to have antiviral properties. This trio of herbs not only has antiviral prop...
We are delighted to welcome Dr. Gretchen Frey back to the podcast. We first interviewed Gretchen right after she retired from her specialty in Obstetrics and Gynecology. She practiced Gynecology from 2010 until 2021. She is now completely retired from clinical practice focusing primarily on sexuality education. Sabitha and Jane taught a pre-conference seminar with Gretchen a few years ago with another colleague and had a great time working together! During her years of working as a physician, she developed special expertise in treating older adults and saw many patients with formerly undiagnosed sexually transmitted infections or STIs. A number of our listeners have asked us to focus more on this area so we asked Gretchen to come back and talk with us about STIs. She talks with Sabitha and Jane about STIs and focuses specifically on Herpes Simplex Virus. She provides us with a common sense approach to testing, treatment, and the difficult issue of shame. If you'd like to learn more about Dr. Frey, check out her website. If you want to catch up on other shows, just visit our website and please subscribe! We love our listeners and welcome your feedback, so if you love Our Better Half, please give us a 5-star rating and follow us on Facebook and Instagram. It really helps support our show! As always, thanks for listening!
We're back for episode 3 of The Paeds Round with special guest Dr Katy Fidler joining our hosts Emma Lim and Christo Tsilifis to talk about the management of herpes simplex virus. We discuss stigma, when to worry about HSV, the importance of early detection and what to look out for. Katy is a Paediatric Infectious Diseases Consultant in Brighton and a Reader in Paediatrics at Brighton and Sussex Medical School. She also currently runs the national study on neonatal herpes through the British Paediatric Surveillance Unit. This is the final episode in our three-part mini-series on HSV. We'll return in the new year to discuss fever. Download transcript: https://www.rcpch.ac.uk/sites/default/files/2023-12/The-paeds-round-transcript-HSV-management.pdf This podcast is a collaboration between the Royal College of Paediatrics and Child Health (https://www.rcpch.ac.uk) and Medisense (https://www.medisense.org.uk). Subscribe to The paeds round for more educational episodes! And, you can find more RCPCH educational resources on RCPCH Learning (https://learning.rcpch.ac.uk). Want to hear more from RCPCH? Search for and subscribe to RCPCH Podcasts, our main channel.
We're back for episode 2 of The Paeds Round with special guest Dr Hermione Lyall joining our hosts Emma Lim and Christo Tsilifis to talk about maternal to child transmission of herpes simplex virus and the importance of early detection of this rare condition. Hermione is a paediatric infectious diseases consultant at St Mary's hospital in London and brings a wealth of experience to this discussion. She has a special interest in congenital infections and has worked tirelessly to prevent their transmission, which she discusses at length in this second of our three-part series on HSV. Listen out for the third part of this series on 19 December. Download transcript: https://www.rcpch.ac.uk/sites/default/files/2023-12/Transcript-The-paeds-round-2-neonatal-HSV-transmission.pdf This podcast is a collaboration between the Royal College of Paediatrics and Child Health (https://www.rcpch.ac.uk) and Medisense (https://www.medisense.org.uk). Subscribe to The paeds round for more educational episodes! And, you can find more RCPCH educational resources on RCPCH Learning (https://learning.rcpch.ac.uk). Want to hear more from RCPCH? Search for and subscribe to RCPCH Podcasts, our main channel. Resources relating to this episode The British Association of Sexual Health and HIV (BASSH) is updating its clinical guideline, Management of Anogenital Herpes in Pregnancy and the Neonate. The advice for prophylaxis in pregnancy has been updated to: “Start aciclovir from 32 weeks generally or 22 weeks in any woman where there is a suspected risk of prematurity”. Video: Dr Hermione Lyall | PaeCH Teaching for Trainees - https://www.youtube.com/watch?v=5XE1gjt_Vq0 Samies NL, James SH, Kimberlin DW. Neonatal Herpes Simplex Virus Disease: Updates and Continued Challenges. Clin Perinatol. 2021 Jun;48(2):263-274. doi: 10.1016/j.clp.2021.03.003. PMID: 34030813. Melvin AJ, Mohan KM, Vora SB, Selke S, Sullivan E, Wald A. Neonatal Herpes Simplex Virus Infection: Epidemiology and Outcomes in the Modern Era. J Pediatric Infect Dis Soc. 2022 Mar 24;11(3):94-101. doi: 10.1093/jpids/piab105. PMID: 34894240; PMCID: PMC8946680. Waheed S, Nuttall L, Fidler K, Dudley J, Bamford A, Lyall H. Neonatal Herpes Simplex Virus: Cutaneous Recurrence Is Common on Stopping Prophylactic Suppression Therapy. J Pediatric Infect Dis Soc. 2022 Dec 5;11(11):518-521. doi: 10.1093/jpids/piac098. PMID: 36048737.
Though common and self-limiting in older children and adults, herpes simplex viral infection can cause a spectrum of neonatal disease from simple lesion to devastating encephalitis. How can we identify babies at risk and provide appropriate treatment? In this episode, Sarah discusses her devastating story of losing a child to neonatal HSV and her work in raising awareness of neonatal HSV. Featuring Emma Lim and Christo Tsilifis with Sarah de Malplaquet, parent of Kit, and founder of the Kit Tarka Foundation. See transcript at https://www.rcpch.ac.uk/sites/default/files/2023-10/The-paeds-round-HSV-infection-transcript.pdf This podcast is a collaboration between the Royal College of Paediatrics and Child Health (https://www.rcpch.ac.uk) and Medisense (https://www.medisense.org.uk). Subscribe to The paeds round for more educational episodes! And, you can find more RCPCH educational resources on RCPCH Learning (https://learning.rcpch.ac.uk). Want to hear more from RCPCH? Search for and subscribe to RCPCH Podcasts, our main channel.
In this episode I share holistic remedies, nutritional and lifestyle suggestions to improve herpes virus and strengthen the immune system naturally.Download my candida, parasite and gut guide! https://holisticspring.com/product/candida-parasite-leaky-gut-bundleJoin My Holistic Community: www.holisticspring.org
Dr. Lauren Oldfield, Director of Synthetic Genomics, Replay April 17, 2023 In this episode, we discuss efforts to develop large DNA viruses, such as herpesviruses, as vectors to deliver gene therapies, including advantages over other types of pathogen platforms. Notably, large viruses enable the delivery of larger genes for therapeutic purposes, and the characteristics of herpes simplex viruses (HSV) can allow gene therapies to be delivered over longer periods of time.
On episode #30 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/24 – 6/7/23. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Foodborne illness outbreaks at retail food establishments (CDC) Donor-derived fulminant herpes simplex virus hepatitis after liver transplantation (TID) High-dose influenza vaccine is associated with reduced mortality among older adults with breakthrough influenza (CID) Letermovir vs valganciclovir for prophylaxis of cytomegalovirus in high-risk kidney transplant recipients (JAMA) Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with pneumonia (CC) Safety of Streptococcus pyogenes vaccines (CID) Meningococcal ACWYX conjugate vaccine in 2 to 29 year olds (NEJM) Orthopaedic surgical management of pressure-ulcer related pelvic osteomyelitis (OFID) On culture and blood cultures (CMI) Benchmarking of outpatient pediatric antibiotic prescribing (JPIDS) Outbreak of suspected fungal meningitis in US patients who underwent surgical procedures under epidural anesthesia (CDC) Risk of systemic fungal infections after exposure to wildfires (The Lancet) Giardia duodenalis and dysentery in Iron Age Jerusalem (Parastiology) Community water fluoridation levels to promote effectiveness and safety in oral health (CDC) Music is by Ronald Jenkees
In this episode of the Conversations with a Dom BDSM podcast Moineau and Chief talk to Emily, a reader who emailed in asking if she could share her experiences of engaging in a D/s dynamic after testing positive for the Herpes simplex virus (HSV). We talk about:What HSV is and what the symptoms areHow Emily contracted HerpesWhat she does and doesn't do in her dynamic to keep herself and others safeHow it impacts play with her Dom--------------For Doms: Sensational Scenes: How to Heighten Arousal, Induce Subspace, and Have Mind-Blowing Sexual Experiences in Dom sub Relationships. Pick up a copy of my ebook today (https://kinkyevents.co.uk/book). For subs: Learn The Art of Submission. Become a confident submissive and make your kinky fantasies a reality with our online video course for subs (https://kinkyevents.co.uk/aos). For all: Rope bondage. Learn rope bondage for D/s couples with our online video course Sinful Shibari (https://kinkyevents.co.uk/sinful-shibari). The Kinky Events online community. Connect with like-minded Doms and subs in a safe, anonymous, consensual space to discuss D/s (not a dating site) (https://kinkyevents.co.uk/dom-sub-community/). Freebies: Free ebook, sex menu template, and email content ...
There are over 100 herpes viruses. HSV-1 and HSV-2 are common skin conditions and affect a considerable portion of the population. According to the World Health Organization, an estimated 3.7 billion people under age 50 have HSV-1, and 491 million people under 50 have HSV-2. In the United States, approximately 22% of pregnant women have HSV-2. Most of these mothers have the virus before getting pregnant, and 2% of expecting mothers will acquire HSV-1 or HSV-2 during their pregnancy. Other than an occasional outbreak, no long-term adverse health outcomes exist in adults with HSV. Only about 5–15% of infected individuals report symptoms. An HSV infection in a newborn can be a severe condition with detrimental effects. The good news is that transmission rates during pregnancy and birth are low. Learn how the herpes simplex virus can affect you and your baby during pregnancy, what medications are safe to use, and how to prevent transmission to your baby. Thank you to our sponsors FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase of AG1. With one delicious scoop of AG1, you're absorbing 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to help you start your day right. This special blend of ingredients supports your gut health, nervous system, immune system, energy, recovery, focus, and aging. As a friendly reminder, pregnant or nursing women should seek professional medical advice before taking this or any other dietary supplement. Read the full article and resources that accompany this episode. Join Pregnancy Podcast Premium to access the entire back catalog, listen to all episodes ad-free, get a copy of the Your Birth Plan Book, and more. Check out the 40 Weeks podcast to learn how your baby grows each week and what is happening in your body. Plus, get a heads up on what to expect at your prenatal appointments and a tip for dads and partners. For more evidence-based information, visit the Pregnancy Podcast website.
Listen in as Kristin speaks to Dr Melanie Bissessor from the Melbourne Sexual Health Centre with an update on HSV.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.06.523065v1?rss=1 Authors: Feng, J., Tang, Y., Fu, W., Xu, H. Abstract: The highly prevalent herpes simplex virus type 1 (HSV-1) causes keratoconjunctivitis and encephalitis. Viral DNA polymerase-inhibiting nucleoside analogs (such as acyclovir) are standard treatment agents against HSV infections but are limited by severe drug resistance issues. Thus, new antiviral agents with novel targets are urgently needed. Earlier, we investigated the anti-cancer, anti-inflammatory, and antibacterial bioactivities of Garcinia sp. Here, we report that non-cytotoxic concentrations ( less than 500 nM) of Gaudichaudione H (GH, isolated from Garcinia oligantha Merr.) potently inhibits HSV-1 replication in vitro without affecting viral entry or attachment. GH inhibits the expression of the viral proteins ICP0, ICP4, and ICP27 without affecting their mRNA levels. In Vero cells, GH enhanced STAT1 and 3 phosphorylation, which occurs downstream to interferon (IFN)-{gamma} activation during viral infections. However, pharmacological/genetic inhibition of IFN-{gamma} failed to suppress the GH-mediated inhibition of HSV-1 replication, indicating that GH exerts antiviral effects independent of IFN. Further mechanistic studies suggest that GH inhibits HSV-1 replication, at least partially by inhibiting cellular NF-{kappa}B activation. Moreover, GH prolonged the survival rate of KOS-infected mice by 25% (n = 5). In conclusion, GH treatment inhibits HSV-1 replication both in vitro and in vivo; therefore, it can be developed as an antiviral. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Merry Christmas everyone! I am giving you the gift of sex positivity and herpes simplex virus (HSV) awareness today with my guest, Trisha of Safe Slut! Trisha is a safe sex advocate and is big on Instagram and TikTok for her transparency of living with HSV 2. A fan requested that I reach out to her for all of the awareness work that she does so I was stoked when she was willing to come on to share her story. As human beings, we all have sex. As sex workers, some of us choose to engage in FSSW, pornography and collaborations with other creators so frequent testing and being aware of what to look out for when it comes to HSV specifically. Trisha has immersed herself completely in learning as much information about the virus, how its contracted and how it spreads, and how to navigate conversations about STIs with your partners, clients or people you might be sleeping with. It's an insanely informative episode and I hope you all enjoy the episode! Happy holidays! linktr.ee/safe.slut Stripped by SIA was nominated for a 2023 AVN Award for Favorite Adult Podcast! I'd appreciate your support by voting once per day until January 7th, 2023 at 12:00pm PST. Please visit the link below to cast your vote: avn.com/awards/voting/favorite-adult-podcast Fox Digital is an official partner of the show. Stripped by SIA listeners get 20% off! Message Anthony on https://foxdigital.design and mention the show to take advantage of big savings on your website. Watch the video exclusive only on Patreon: www.patreon.com/strippedbysia Don't forget to LIKE, SHARE, COMMENT, RATE, REVIEW and SUBSCRIBE! twitter.com/strippedbysia instagram.com/strippedbysia patreon.com/strippedbysia www.strippedbysia.com
Researchers Use Teeth to Discover the Origin of Herpes Simplex Virus By Spring Hatfield, RDH, BSPH Original article published on Today's RDH: https://www.todaysrdh.com/researchers-use-teeth-to-discover-the-origin-of-herpes-simplex-virus/ This audio article is sponsored by LISTERINE®. Although LISTERINE® Antiseptic is the most extensively tested over-the-counter mouthrisnse in the world, with over 30 long-term clinical trials examining its safety and efficacy, there is still some misinformation out there over the uses of mouthrinses containing alcohol. To help understand the safety of alcohol-containing mouthrines, in case any patients ask you about it, head on over to https://rdh.tv/ListerineSafety Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/ Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/ Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.23.509057v1?rss=1 Authors: Aubert, M., Haick, A. K., Strongin, D. E., Klouser, L. M., Loprieno, M. A., Stensland, L., Santo, T. K., Huang, M.-l., Hyrien, O., Stone, D., Jerome, K. R. Abstract: Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent HSV, and thus is only suppressive rather than curative. We developed a potentially curative approach to latent HSV infection and pathogenesis, based on gene editing using HSV-specific meganucleases delivered by adeno-associated virus (AAV) vectors. Our results demonstrated that a dual meganuclease therapy, composed of two anti-HSV-1 meganucleases delivered by a triple AAV serotype combination (AAV9, AAV-Dj/8, AAV-Rh10), can eliminate up to 97% of latent HSV DNA from ganglia in both ocular and vaginal mouse models of latent HSV infection. Using a novel pharmacological approach to reactivate latent HSV-1 in mice with the bromodomain inhibitor JQ-1, we demonstrated that this reduction in ganglionic viral load leads to a significant reduction of viral shedding from treated vs. control mice, with many treated mice showing no detectable virus shedding. In general, therapy was well tolerated, although dose-ranging studies showed hepatotoxicity at high AAV doses, consistent with previous observations in animals and humans. Also in agreement with previous literature, we observed subtle histological evidence of neuronal injury in some experimental mice, although none of the mice demonstrated observable neurological signs or deficits. These results reinforce the curative potential of gene editing for latent orofacial and genital HSV disease, and provide a framework for additional safety studies before human trials can begin. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer
In this episode we chat to Shelley, a mum of two from Adelaide. Shelley reached out to us shortly after having her baby because she wanted to share the unique circumstances surrounding her first birth and VBAC. Shelley lives with Herpes Simplex Virus 1 Genital, it is classified as a type of STI, and because of the stigma this carries Shelley could not find any stories from women who have navigated pregnancy and birth with this condition. It is estimated that three-quarters of Australian adults are infected with HSV1.Shelley talks about how her genital herpes affected the outcome of her first birth, and although a very empowering and positive caesarean she still held the desire to have a VBAC for next time. Unlike her first birth genital herpes didn't play a role in the outcome of her second birth, however being covid positive at the time her body went into labour certainly did. Shelley got covid twice during her VBAC pregnancy.Although her VBAC didn't go the way Shelley envisioned- there was intervention there- she felt in control the entire time due to the preparation she had done during her VBAC pregnancy. Shelley also shares how she had a positive breastfeeding journey with her second baby, which wasn't the case with her first baby. A big thank you to our patrons for helping to bring this episode to you. Please consider supporting the podcast from as little as $2 a month. Your donations go toward the up-keeping costs of running the podcast and really help us to keep going x https://www.patreon.com/vbacbirthstories~ AFFILIATES ~Access discounts with our amazing affiliates:Birth Time film:DISCOUNT CODE: CICADA20https://www.birthtime.world/a/2147503775/Eb2KfvxtPartum Panties:DISCOUNT CODE: Vbacbirthstorieshttps://www.partumpanties.com.auThe Birth Store:DISCOUNT CODE: VBAChttps://thebirthstore.com.au/?ref=VBAC~ Notes ~Books:The Birth Map by Catherine BellBirth Skills by Juju Sundin with Sarah MurdochPregnancy Loss:Https://www.bearsofhope.org.auHttps://rednosegriefandloss.org.auHttps://miscarriagessupport.org.au**VBAC Birth Stories features women's lived experiences. It is not intended to replace medical advice. Should you have any concerns during your pregnancy please always consult your healthcare provider.Please connect with us on Facebook or Instagram: @vbacbirthstories
Herpes Simplex Virus – apparently most of you have got it, even if you didn't know anything about it. But is this really true? What actually causes cold sores and genital herpes? Let's take a deep dive into the science behind these claims, including the 1920 experiments that are the basis to the whole virus transmission story. Show notes
How do we tap into bravery? What does it mean to live bravely? I hope you're hungry because this episode is RICH with GOLDEN NUGGETS that will undoubtedly inspire you to connect with your truth, find your voice, become a visionary for your life and build your dreams step by step. BUT here's the clincher…. you're going to learn how to do this while holding space for ALL OF YOUR VERY HUMAN FEELINGS… and this idea is what today's guest calls LIVING BRAVE. Shoshanna Raven is using her own story of resilience, self-transformation and overcoming, to guide women through the journey of radical self-expression and business growth, to amplify their impact & income, and quantum leap towards their unique vision. Hers is a story of GOING FOR IT… asking for more from life… digging deeper into the psyche and the soul… by holding both self-belief and self-doubt in one hand. Shoshana talks us through what it takes to step out into the unknown, with confidence. In 2015, Shoshana traded corporate consulting for a one-way ticket to India. After a yoga teacher training, traveling through more than 30 countries, and experiencing a successful career in business journalism, she launched the Living Brave podcast… which expanded into a community of thousands, sold-out international retreats and signature coaching programs. Shoshana's humble beginnings grew from a 1-woman show to a $7 figure/year business & a global team in 1.5 years. Plus - Shoshana's life began changing in a major way thanks to a bold but subtle and hard to predict turning point; it was the moment she started sharing publicly about living with Herpes Simplex Virus. This prompted the Living Brave podcast which took the world by storm.
Sammy C welcomes Ellen back for Episode number 30 of Straight to Voicemail with Sammy C! They talk about their recent battle with Herpes, Joe Rogan, and their new hatred for Jack and Jill! --- Support this podcast: https://podcasters.spotify.com/pod/show/sam-commodari/support
Oncotarget published "Host targeted antiviral (HTA): functional inhibitor compounds of scaffold protein RACK1 inhibit herpes simplex virus proliferation" which reported that due to the small number of molecular targets in viruses and the rapid evolution of viral genes, it is very challenging to develop specific antiviral drugs. In addition, HIV-1 and Herpes Simplex virus are known to use IRES as well. By utilizing the crystal structure of the RACK1A protein from the model plant Arabidopsis and using a structure based drug design method, dozens of small compounds were identified that could potentially bind to the experimentally determined functional site of the RACK1A protein. Dr. Sivanesan Dakshanamurthy from The Georgetown University Medical Center, Dr. Qiyi Tang from The Howard University College of Medicine and Dr. Hemayet Ullah from Howard University said, "With the small number of molecular targets in viruses and the rapid evolution of viral genes, it is very challenging to develop specific antiviral drugs." Full press release - https://www.oncotarget.com/news/pr/functional-inhibitor-compounds-inhibit-herpes-simplex-virus-proliferation/ DOI - https://doi.org/10.18632/oncotarget.26907 Full text - https://www.oncotarget.com/article/26907/text/ Correspondence to - Sivanesan Dakshanamurthy - sd233@georgetown.edu, Qiyi Tang - qiyi.tang@howard.edu, and Hemayet Ullah - hullah@howard.edu Keywords - host targeted antiviral (HTA), herpes simplex virus (HSV), receptor for activated C kinase 1 (RACK1), RACK1 inhibitor, internal ribosomal entry site (IRES) About Oncotarget Oncotarget is a biweekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105
This week, Steph gives an overview on the Herpes Simplex Virus. She discusses the differences between HSV-1 and HSV-2, how both can be spread, and what the symptoms are.Previous STD Series Episodes:045 | I Have the STD & All I Need is U046 | Chlamydia, Gonorrhea, & Syphilis, OH MY!
This week we discuss Herpes Simplex Virus 1 & 2 (HSV 1&2) with special guest Dr. Cherlisa Jackson, Ph.D. Let's debunk myths and become informative about this medical diagnosis that is not spoke about enough. You can find more about Dr. Cherlisa on her website https://www.sheerllc.com and social media handle @synclairejames. RESEARCH ARTICLE: African American Females and Herpes Simplex Virus 2: A Basic Interpretive Qualitative Study by: Dr. Cherlisa Jackson https://scholarworks.waldenu.edu/cgi/viewcontent.cgi?article=11860&context=dissertations Take a listen and share with others! BWH healing workbook can be found at: amzn.to/3kpZZF1 Looking for an editor, graphic designer, or any other freelancer check out Fiverr Link: fvrr.co/3xIpVA1 Buy "Healing on the Daily" Glass Mugs: www.bwhpodcast.com/product-page/he…f8-799ecc7033cb Check out BWH website at: www.bwhpodcast.com If you are interested in being a guest, please find form here: linktr.ee/bwh_pod
An interview with Dr. Bianca Santomasso from Memorial Sloan Kettering Cancer Center, author on “Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update.” She reviews neurologic toxicities in patients receiving ICPis, such as myasthenia gravis, Guillain-Barre Syndrome, peripheral neuropathy, aseptic meningitis & encephalitis in Part 9 of this 13-part series. For more information visit www.asco.org/supportive-care-guidelines TRANSCRIPT [MUSIC PLAYING] SPEAKER: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. BRITTANY HARVEY: Hello and welcome to the ASCO Guidelines Podcast series, brought to you by the ASCO Podcast Network, a collection of nine programs covering a range of educational and scientific content, and offering enriching insight into the world of cancer care. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey. And today, we're continuing our series on the management of immune related adverse events. I am joined by Dr. Bianca Santomasso from Memorial Sloan Kettering Cancer Center in New York, New York, author on Management of Immune Related Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Therapy ASCO Guideline Update and Management of Immune Related Adverse Events in patients Treated with Chimeric Antigen Receptor T Cell Therapy ASCO Guideline. And today, we're focusing on nervous system toxicities in patients treated with immune checkpoint inhibitor therapy. Thank you for being here, Dr. Santomasso. BIANCA SANTOMASSO: Thank you for having me. BRITTANY HARVEY: Then I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The full conflict of interest information for this guideline panel is available online with the publication of the guidelines in the Journal of Clinical Oncology. Dr. Santomasso, do you have any relevant disclosures that are directly related to these guidelines? BIANCA SANTOMASSO: Yes, I'd like to disclose that I've served as a paid consultant for Celgene, Janssen Pharmaceutical, and Legend Biotech for advising them on the topics of T cell therapy side effects. BRITTANY HARVEY: Thank you. Then getting into the content of this guideline, what are the immune related nervous system toxicities addressed in this guideline? And what are the overarching recommendations for evaluation of these neurologic immune related adverse events? BIANCA SANTOMASSO: So neurologic immune related adverse events actually encompass a very diverse spectrum of neurologic syndromes that can occur as a complication of treatment with checkpoint inhibitors. So the spectrum that is covered by this guideline includes myasthenia gravis, Guillain-Barre syndrome, polyneuropathy, aseptic meningitis, and encephalitis. And although these are rarer than many of the other immune related adverse event types affecting other organ systems, they're increasingly being encountered due to more patients being treated with novel combinations of immunotherapies. And they're important to recognize, because along with myocarditis, they have generally more morbidity and even more mortality than irAEs affecting other organ systems. So it's important for clinical care providers to have a high index of suspicion for these events. Studies have suggested that these tend to occur in about 3% to 12% of patients, probably between 1% and 2% of patients developing severe events. So they're rare. But again, the events are probably more commonly seen in patients treated with combination checkpoint blockade. And we're increasingly seeing more combinations. So we should be on the lookout for these. Neurologic immune related adverse events can be divided into syndromes that affect the peripheral nervous system, so meaning the peripheral nerves, the neuromuscular junction, and muscle. So that would be Guillain-Barre syndrome, myasthenia gravis, and myositis. And those that affect the central nervous system, such as the brain, spinal cord, or leptomeninges. So those would be aseptic meningitis and encephalitis. The peripheral nervous system irAE appear to be more common than those affecting the central nervous system. And patients can present with a number of different symptoms that kind of relate to these syndromes. That can be as diverse as a headache to numbness, tingling, or focal weakness, such as a foot drop or facial weakness. You may see patients with severe altered mental status or personality changes or gait difficulty, walking difficulty, which could actually mean any number of syndromes. It's generally important to be aware that the timing of onset is generally early, a median of four weeks after the start of treatment, but can range anywhere from one week after the start of treatment to greater than a year. And because we know that cancer can spread to many parts of the nervous system, neurologic toxicity should be considered a diagnosis of exclusion. So that means that as part of the workup for neurologic immune related adverse events, it's imperative to rule out nervous system metastasis, stroke, and infection, which we know can occur at higher rates in patients with cancer. So for most neurologic immune related adverse events, diagnostic workup is similar. It should include MRI brain and/or of the spine, with and without contrast, and often a lumbar puncture for cerebrospinal fluid analysis, including cytology to rule out leptomeningeal metastasis. BRITTANY HARVEY: Thank you for that overview. In addition to those points for evaluation for all nervous system toxicities, what are the key recommendations for identification, evaluation, and management of myasthenia gravis? BIANCA SANTOMASSO: So for myasthenia gravis, presenting symptoms usually include fatiguable or fluctuating muscle weakness. It's generally more proximal than distal. And there's frequently ocular and/or bulbar involvement. So that means either ptosis, like a droopy eyelid, diplopia, or double vision, difficulty swallowing, dysarthria, facial muscle weakness, and/or head drop or neck weakness. Again, for any patient with new neurologic symptoms, an MRI of the brain or spine should be performed depending upon the symptoms to rule out central nervous system involvement by disease or some alternative diagnosis. And similar to idiopathic myasthenia gravis, acetylcholine receptor antibodies can be positive. So these should be checked. This is a blood test. But it's important to note that while these antibodies may be confirmatory, their absence does not rule out the syndrome. The rate of acetylcholine receptor antibody positivity in immune related myasthenia gravis has not been definitively established. So depending on the presentation, one might also consider sending a paraneoplastic panel for Lambert-Eaton myasthenic syndrome. The single most important point I'd like to make regarding suspected immune related myasthenia gravis is that orbital myositis and generalized myositis from immune checkpoint inhibitors can present similarly. For this reason, early neurology consultation and electrodiagnostic testing with repetitive stimulation or single fiber EMG becomes important and helpful to distinguish the two. And to make matters even more complicated, we've learned that there's an overlap syndrome, where patients may develop not only myasthenia gravis, but also myositis and/or myocarditis at the same time. So basically, the neuromuscular junction is affected. But the local muscle and myocardium, which is heart muscle that's kind of related, may be affected all at once. And this overlap of syndromes may increase disease severity and mortality. So they're important to recognize. So what this means is that when you encounter a patient with suspected myasthenia gravis, you should also be checking CPK, muscle enzymes, aldolase to evaluate for myositis, and troponin and electrocardiogram to evaluate for myocarditis. And this should be done even if there are no obvious symptoms. So onto the treatment of myasthenia gravis, this is similar to the management of the idiopathic form. Therefore, it's helpful to have the involvement of a neurologist. The immune checkpoint inhibitor therapy should be held. And patients with mild symptoms are often started on pyridostigmine and corticosteroids. And patients with more severe symptoms should initiate IVIG or plasmapheresis. And patients with more severe symptoms may need to be admitted to the hospital. So that their neurologic and pulmonary status can be monitored closely for improvement. Some patients may require ICU level of monitoring. And considering adding rituximab if symptoms are refractory, and often, as symptoms improve, the steroids can be de-escalated. BRITTANY HARVEY: Understood. Those are all very important points for clinicians to consider. So then following that, what are the key recommendations for identification, evaluation, and management of Guillain-Barre syndrome? BIANCA SANTOMASSO: So Guillain-Barre syndrome, like myasthenia gravis, also presents with weakness. Most often, patients present with a progressive ascending muscle weakness. The syndrome can start with sensory symptoms or neuropathic pain that can be localized to the lower back and thighs. In addition to the classic ascending weakness, there may be facial weakness, double vision, numbness or tingling in the hands or feet, loss of balance, and coordination. And shortness of breath may occur due to respiratory muscle weakness. The autonomic nerves can also be affected and can present as new severe constipation or nausea, urinary problems, or orthostatic hypotension. The reflexes are often reduced or absent, deep tendon reflexes. So again, as for all of the syndromes, early involvement by a neurologist is recommended, if possible. Usually, MRI imaging of the spine is important to rule out spinal cord compression. And it also may show cauda nerve thickening or enhancement, which can occur with this syndrome. And the second aspect is cerebrospinal fluid analysis is important for diagnosis. This is important really for ruling out leptomeningeal metastasis, since that could present similarly. And often, what can be seen in GBS is an elevated protein level in the cerebrospinal fluid. In addition, unlike idiopathic GBS, there can be an elevated white blood cell count in the cerebrospinal fluid. Electrode diagnostic testing can also be helpful for confirmation, and serum tests for antiganglioside antibodies, and a paraneoplastic antibody workup may also be considered. Bedside pulmonary function test and swallowing evaluation should be performed if there's a concern for respiratory or swallowing dysfunction. And some patients do need to have inpatient admission and monitoring if symptoms are severe or if they appear to be progressing from mild. For management, the checkpoint inhibitor therapy should be held. And patients are most often treated with IVIG or plasmapheresis. Corticosteroids can be added to the IVIG or plasmapheresis. These are not usually recommended for idiopathic Guillain-Barre syndrome. However, in immune checkpoint inhibitor related forms, a trial is reasonable. And steroids are usually given at a higher dose for five days and then tapered over several weeks. BRITTANY HARVEY: Understood. I appreciate that overview. So then what are the key recommendations for identification, evaluation, and management of peripheral neuropathy? BIANCA SANTOMASSO: So peripheral neuropathy, or polyneuropathy, is a rare but likely underreported complication of immune checkpoint inhibitor therapy. So in the large databases and meta-analyses, those have really focused on Guillain-Barre syndrome for reporting. But other types of neuropathies, such as painful length dependent sensory and motor axonal neuropathies, or polyradiculopathies or sensory neuropathies do occur after immune checkpoint inhibitors and are probably under-recognized. So evaluation of immune related neuropathy should include neurology consultation to guide the neurology phenotype determination and also the workup. The evaluation primarily relies on a combination of electrodiagnostic studies, serologic tests, and MRI neuroimaging. Because peripheral nervous syndromes can overlap, screening for neuromuscular junction dysfunction with electrodiagnostic testing and myopathy is recommended for any patient who presents with at least motor symptoms that are thought to be peripheral. Serum testing can be helpful for ruling out reversible causes of neuropathy. Spinal imaging is recommended to exclude metastatic disease. And for management, it usually involves holding the checkpoint inhibitor in mild cases, using neuropathic pain medication or steroids in more severe cases. And very severe cases that kind of resembled GBS would be managed as per the GBS algorithm with IVIG or plasmapheresis. BRITTANY HARVEY: Understood. And it's key to look out for those overlapping adverse events. So then following that, what are the key recommendations for aseptic meningitis? BIANCA SANTOMASSO: Right, so now we're getting into the central nervous system toxicity. So aseptic meningitis is an inflammation of the meninges. And it can present with headache, photophobia, neck stiffness. Patients can have nausea, and vomiting, and occasionally fever. The mental status is usually normal. And in patients presenting with headache, which in isolation, could suggest an aseptic meningitis, it's important to evaluate if they have any confusion or altered behavior, which might suggest an encephalitis. And this distinction is important, because suspected encephalitis triggers a different workup, which we'll be discussing later, and also even different management. So the workup for aseptic meningitis includes neuroimaging, usually an MRI of the brain. And on that imaging, we sometimes see abnormal leptomeningeal enhancement. It's important not to assume that this is cancer and to do a lumbar puncture to evaluate cerebrospinal fluid both for inflammation and to exclude other causes of meningeal disease, particularly neoplastic and infectious causes. So cytology, Gram stain, and culture, and other infectious studies should be negative. And it's recommended that empiric antibiotics or antiviral therapy be considered to cover for infectious meningitis until the cerebrospinal fluid results return negative. What's seen in the cerebrospinal fluid in aseptic meningitis is typically reactive lymphocytes, but also neutrophils or histiocytes may be prominent on the cytology. And while the symptoms can be severe, sometimes requiring hospitalization, the management of this entity, these are usually quite treatable. Aseptic meningitis generally responds very well to corticosteroids. So management involves holding the checkpoint inhibitor. And you can often get away with starting a fairly modest dose of corticosteroids, such as oral prednisone, 0.5 to 1 milligram per kilogram or the equivalent. And steroids can usually be tapered over two to four weeks. BRITTANY HARVEY: Great, thank you for reviewing those recommendations. So then you just mentioned the distinction of aseptic meningitis and encephalitis. So what are those key recommendations for identification, evaluation, and management of encephalitis? BIANCA SANTOMASSO: So in encephalitis, the mental status is not normal. It's characterized by, really, an acute or subacute confusion, altered mental status, altered behavior, memory deficits, including working memory and short-term memory. There can be, as associated symptoms, headaches, new onset seizures, psychiatric symptoms, which can include delusions or hallucinations. There could be weakness, sensory changes, imbalance, or gait instability, along with the mental status changes. And so similar to aseptic meningitis, the other central nervous system toxicity, it's important to distinguish encephalitis from other causes of altered mental status, such as CNS metastases, stroke, or infection. And as for the other syndromes, it's very helpful to have neurologic consultation early, if possible. An MRI of the brain is critical. And in addition, MRI of the spine may be obtained to evaluate for inflammatory demyelinating ischemic or metastatic lesions. In immune related encephalitis, MRI brain imaging may reveal T2 flare changes, typical of what can be seen in idiopathic autoimmune or limbic encephalitis. But most often, the MRI imaging is normal. So in this situation, a lumbar puncture for CSF studies to evaluate for evidence of inflammation can be very helpful. You can expect to see either a lymphocytic pleocytosis or an elevated protein, or CSF restricted oligoclonal bands. CSF analysis is also helpful for excluding other causes of encephalitis, particularly viral encephalitis. So HSV, Herpes Simplex Virus, or varicella zoster virus encephalitis should be ruled out and treated with antivirals while the tests are pending. So typically, these entities can be excluded by PCR testing for HSV and VZV. Electroencephalogram, or EEG, can also be helpful for revealing subclinical seizures or status epilepticus, which can occur as a complication of encephalitis or as a cause of persistently depressed sensorium. But these are not specific to encephalitis. Other testing that's done includes screening metabolic tests to look for alternative etiologies. And for this entity, serum and CSF autoimmune antibody evaluation should be sent to assess for malignancy associated neurologic syndromes. And your neurologist can help you with the workup and management, in particular which tests to send. There have been reported cases of antibody positive checkpoint inhibitor related encephalitis. For management, in contrast to aseptic meningitis, these are generally not as steroid sensitive. So you often have to treat with either higher steroid doses, even pulsed steroid doses, along with IVIG or plasmapheresis. If no improvement, escalation to rituximab and cyclophosphamide can be considered, with the assistance of neurology. This management guidance is taken from how to treat autoimmune encephalitities that are not related to checkpoint inhibitors. Unfortunately, these can be difficult to treat. The response may only be partial. So this is one area in need of better understanding of best therapeutics. BRITTANY HARVEY: OK, thank you for reviewing that and pointing out where there's future research needed as well. And I appreciate your reviewing the recommendations for each of these neurologic immune related adverse events. So then to wrap us up, in your view, how will these recommendations for the management of nervous system toxicities impact both clinicians and patients? BIANCA SANTOMASSO: Yeah, so I think this is a daunting list of toxicities. But I'll say that in most situations, the immune checkpoint inhibitor side effects are often manageable and reversible with proper supportive care. They can be serious, and they require close vigilance and prompt treatment and identification. But by knowing what to look for in early identification, that allows early intervention, which is really the key to reversibility and the best outcomes. So having these toxicities on your differential diagnosis is critical. And I think these guidelines really help inform both clinicians, and care providers, and patients on what the possible manifestations are. So we believe this guideline and its recommendations will help members of clinical teams with the recognition and the management of these unique toxicities. And again, it's timely recognition and early intervention that helps patients, really, by increasing their safety with early management. BRITTANY HARVEY: Great, well, thank you for your work on these guidelines and for taking the time to speak with me today, Dr. Santomasso. BIANCA SANTOMASSO: My pleasure. Thank you so much. BRITTANY HARVEY: And thank you to all of our listeners for tuning in to the ASCO Guidelines Podcast series. Stay tuned for additional episodes on the management of immune related adverse events. To read the full guideline, go to www.asco.org/supportive care guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, available in iTunes or the Google Play store. If you have enjoyed what you've heard today, please rate and review the podcast. And be sure to subscribe. So you never miss an episode. [MUSIC PLAYING]
HERE WE ARE AGAIN bringing some flavour to your Friday! Today is a SPECIAL episode featuring Bek Antonucci where we discuss how she has grown into such a bad ass human after a confronting and vulnerable diagnosis of Herpes Simplex Virus or HSV2. There are some INTIMATE and personal details shared in this ep but you're going to have to stay tuned to find out the juicy goss!For anyone struggling with this or any other issues, please feel free to message us and know we are here for you all 100%Sending love. life and laughter to you always.Where to find Bek:www.instagram.com/bekantonucci/Where to find us:www.instagram.com/the.nourished.nurses/www.instagram.com/keepyourginuppodcast/ --- Send in a voice message: https://anchor.fm/keepyourginup/message
Hallo zusammen, mein Name ist Tobias Fister, ich bin Apotheker und Gesundheitsexperte und heute steht das Thema Herpes im Mittelpunkt. Wie entsteht er, was kann ich dagegen tun und wie kann ich vor allem Herpes vorbeugen. Teilt das eure Erfahrungen bitte mit der Community in den Kommentaren. Schaut auch auf meine Profile: Instagram: https://www.instagram.com/tobias.fister/ Facebook: https://www.facebook.com/tobias.fister.gesundheit/ Website: https://www.tobias-fister.de -------------------------------------------------------------------------- Ihr habt gesundheitliche Fragen, Probleme oder Ähnliches? Dann seht euch meine 1 zu 1 Gesundheitsberatung an und vereinbart ein unverbindliches Kennenlerngespräch: https://www.tobias-fister.de/#coaching --------------------------------------------------------------------------
Dr. Hugh McTavish is the founder and Executive Director of COVID Sanity. He is a Ph.D. biochemist and immunologist and also a patent attorney. He has authored 18 referee scientific journal articles and is the inventor on 21 U.S. patents. He is a practicing patent attorney and a Ph.D. biochemist with extensive experience in the laboratory. He received his Ph.D. in biochemistry from the University of Minnesota in 1992, and his J.D. from the University of Minnesota in 2001. He has started two pharmaceutical companies off of his own inventions. SqaureX, a clinical stage pharmaceutical company developing a topical formulation of the immunomodulator squaric acid dibutyl ester for the prevention of recurrent cold sores (herpes labialis) and other infections caused by Herpes Simplex Virus 1 or Herpes Simplex Virus 2, and IGF Oncology, LLC, searching for a targeted drug for cancer. COVID Lockdown Insanity: The COVID Deaths It Prevented, the Depression and Suicide it Caused, What We Should Have Done, and What It Shows We Could Do Now to Address Real Crises Resources: https://covid-sanity.org https://covid-sanity.org/about/ https://www.linkedin.com/in/hugh-mctavish-b20a49/ https://covid-sanity.org/wp-content/uploads/2020/12/COVID_benefit-harm_analysis_December_2020_v3.pdf https://squarex-pharma.com https://newsdeli.com/2021/06/09/covid-lockdown-insanity-book-released-by-hugh-mctavish-ph-d-immunologist/ HELP ME CROWDFUND MY GAMESTOP BOOK. Go to https://wen-moon.com or join the crowdfunding campaign and pre-order my next book here now - https://www.indiegogo.com/projects/to-the-moon-the-gamestop-saga--2/x/26852333#/ If you haven’t already and you enjoyed this episode, please subscribe to this podcast and our mailing list, and don’t forget, my book, Brexit: The Establishment Civil War, is now out, you’ll find the links in the description below. Express VPN 12 Months 35% off!! - https://www.xvinlink.com/?a_fid=chatter NameCheap - https://namecheap.pxf.io/WD4Xrn Spreaker - https://spreaker.pxf.io/0JmQoL Watch Us On Odysee.com - https://odysee.com/$/invite/@TheJist:4 Sign up and watch videos to earn crypto-currency! Buy Brexit: The Establishment Civil War - https://amzn.to/39XXVjq Mailing List - https://www.getrevue.co/profile/thejist Twitter - https://twitter.com/Give_Me_TheJist Website - https://thejist.co.uk/ Music from Just Jim – https://soundcloud.com/justjim
This is an important episode. When you understand what could be driving your autoimmunity, you have your solutions - STOP SCRATCHING! (listen to the episode if that doesn't make sense!) Many things have been associated with the onset or exacerbation of autoimmune disease, but this easy-to-understand concept (as originally taught by Dr. Tom Culleton DC) really simplifies The 5 Drivers of Autoimmune Disease, which are:1 - Foods and Gut Health. It's now well-established that leaky gut and food sensitivities can cause or contribute to autoimmune disease, and this is an important first place to start. This can be addressed through lab testing or dietary protocols such as an Elimination Diet or Autoimmune Paleo Protocol, as discussed in this episode, and on several related videos on our website.2 - Toxins. Toxins disrupt the immune system, create a stress response, and lead to inflammation. Toxins can both induce and exacerbate autoimmunity, including Mercury, Aluminum, BPA in plastics, air pollution in general, mold and mycotoxins, and many more. These can be tested through Cyrex Array 11 or through various other testing forms that are discussed in the episode. Detox Detox Detox!!3 - Stress. Almost anyone with an autoimmune process going on can tell you that stress makes it worse. Stress can't be avoided, but it can be MANAGED. Stress is not just job, life, bills, relationships, but there is also physical stress (head trauma or other injuries, sedentary lifestyle, overtraining) and toxic stress (see #2) that triggers the same stress response from the pituitary that will flare inflammation, decrease immune defenses, and make autoimmunity worse.4 - Hormones. Hormone fluctuations can cause autoimmune flares, especially CORTISOL (and epinephrine aka adrenaline - the stress response), INSULIN and blood sugar spikes and/or crashes, and ESTROGEN, which is why autoimmunity often flares around puberty, pregnancy, and peri-menopause.5 - Infections and Pathogens. Bugs such as COVID, influenza, Epstein-Barr Virus, Herpes Simplex Virus, Cytomegalovirus, Parvovirus, Lyme disease, Yersinia, H. Pylori, and many more are associated with autoimmunity. It's not always an "infection" like a weekend flu though.“In many cases it is not a single infection but rather the ‘burden of infections' from childhood that is responsible for the induction of autoimmunity.”Infections and autoimmunity - friends or foes? Trends Immunology 2009 Aug 30(8) 409-14 Kivity et al. Each autoimmune puzzle is different, but all 5 of these drivers need to be addressed for success!
All you need to know about the herpes simplex virus in less than 6 mins!
We discuss the types of maternal and neonatal HSV infection, strategies for risk reduction, and evaluation of infants born to mothers with HSV. We are joined by Chelsea Anderson, MD, MHS, Assistant Professor of Neonatal-Perinatal Medicine at the University of Texas Southwestern Medical Center.
This episode covers herpes simplex virus!
This episode covers herpes simplex virus encephalitis!
Hallo zusammen, mein Name ist Tobias Fister, ich bin Apotheker und Gesundheitsexperte und heute steht das Thema Herpes im Mittelpunkt. Wie entsteht er, was kann ich dagegen tun und wie kann ich vor allem Herpes vorbeugen. Teilt das eure Erfahrungen bitte mit der Community in den Kommentaren. Schaut auch auf meine Profile: Instagram: https://www.instagram.com/tobias.fister/ Facebook: https://www.facebook.com/tobias.fister.gesundheit/ Website: https://www.tobias-fister.de
Movin dat body during the 2nd wave, very dope research about black girls sexual health and substance abuse, fucking roommates during the pandemic, who else is fuckin and a possible HSV1 cure. Watch on YouTube: https://youtu.be/t1pYkqYuwZM Self Care Tip: Some ideas on moving your body during the pandemic and a reminder to do body scans. Fuck That (Currents Events): Gene editing may cure Herpes Simplex Virus 1 and who all is having sex during the pandemic according to Match.com Fuck You (Your Lives): 6 stories of non-romantic roommates who began sexual relationships in quarantine Love & Light to our Hoes of the Week! Hoe(s) of the Week: Jordyn M(Geordie Shore), Allonda D(Angelica Pickles), Britney B (AYTO) HASHTAGS Use #InnerHoeUprising and #Podin to keep up with this conversation on social media and let others know that you are listening. SPONSOR(S) Check out The Salon with LaLa Milan right now in Stitcher, Apple, or your favorite podcast app and make sure to subscribe. RELEVANT LINKS AND NOTES Dr. Opara’s Lab: https://www.oparalab.org/ IHU “Herpes Isn’t the End of the World” : Apple Podcast: https://apple.co/2GaIc4h Soundcloud: https://bit.ly/2IoJTK9 WEBSITE InnerHoeUprising.com PAY A HOE http://Paypal.me/innerhoe https://www.patreon.com/InnerHoeUprising WRITE IN EMAIL ihupodcast@gmail.com (mailto:ihupodcast@gmail.com) CALL IN VOICE MAIL (404) 491-9158 SPEAKING GIGS Wanna pay us to VIRTUALLY speak at your school or conference about sex positivity, black feminism, or the other kinds of topics we discuss on this show? We’d love to! To book us, send us a line to ihupodcast@gmail.com MUSIC Love and light to the artists who have lent their music to the pod! Our opening is a remix of “Queen S%!T” by SheReal (https://soundcloud.com/shereal/04-queen-s-t-produced-by) We also play “Kol(ours)” by Amare Symone, “Party on the Weekend" by King Kam X DVRKAMBR, “Keeping it Cool Witchu” by Chhoti Maa, and “Yeah Yeah” wavghxst (https://twitter.com/wavghxst) ENGINEERING AND EDITING BY Sam SOCIAL MEDIA Join our Facebook Group! “Inner Hoe Uprising CUMmunity” https://bit.ly/2NfFH3A Inner Hoe Uprising| IG: @InnerHoeUprising | Twitter: @InnerHoeUprisin Sam | IG & Twitter: @slamridd Travel IG: @carmensamdiego Rob | Art IG: @vanta.blaq | Twitter: @thee_body | OnlyFans: https://onlyfans.com/bbyboirob #black #woman #sex #feminist #womanist #Comedy #raunchy #queer #pride #quiltbang #sexuality #lgbtq #lgbt #funny #agender #transgender #nonmonagamy #feminism #intersectionalfeminism #kink #porn #BDSM #dating #love #relationships #blackwomen #blackpeople #podcast #sexualwellness #sexualhealth
This podcast presents, Dr. Patrick Carolan, a pediatric emergency medicine physician with Minneapolis Children's Hospital and Clinics of Minnesota, who discusses the evaluation of fever in the neonate and young infant. Enjoy the podcast! Objectives: Upon completion of this podcast, participants should be able to: Recognize the implications of fever in the young infant. Discuss the differential diagnosis of fever and critical illness in the young infant. Implement new concepts in risk stratification for evaluating fever in young infants. CME credit is only offered to Ridgeview Providers & Allied Health Staff for this podcast activity. Complete and submit the online evaluation form, after viewing the activity. Upon successful completion of the evaluation, you will be e-mailed a certificate of completion within approximately 2 weeks. You may contact the accredited provider with questions regarding this program at rmccredentialing@ridgeviewmedical.org. Click on the following link for your CME credit: CME Evaluation: "The Approach to Fever in the Young Infant" (**If you are listening to the podcasts through iTunes on your laptop or desktop, it is not possible to link directly with the CME Evaluation for unclear reasons. We are trying to remedy this. You can, however, link to the survey through the Podcasts app on your Apple and other smart devices, as well as through Spotify, Stitcher and other podcast directory apps and on your computer browser at these websites. We apologize for the inconvenience.) DISCLOSURE ANNOUNCEMENT The information provided through this and all Ridgeview podcasts as well as any and all accompanying files, images, videos and documents is/are for CME/CE and other institutional learning and communication purposes only and is/are not meant to substitute for the independent medical judgment of a physician, healthcare provider or other healthcare personnel relative to diagnostic and treatment options of a specific patient's medical condition; and are property/rights of Ridgeview Medical Center & Clinics. Any re-reproduction of any of the materials presented would be infringement of copyright laws. It is Ridgeview's intent that any potential conflict should be identified openly so that the listeners may form their own judgments about the presentation with the full disclosure of the facts. It is not assumed any potential conflicts will have an adverse impact on these presentations. It remains for the audience to determine whether the speaker’s outside interest may reflect a possible bias, either the exposition or the conclusions presented. Ridgeview's CME planning committee members and presenter(s) have disclosed they have no significant financial relationship with a pharmaceutical company and have disclosed that no conflict of interest exists with the presentation/educational event. SHOW NOTES: CHAPTER 1: Today we are talking about fever in the pediatric population, specifically those in the under 3-months of age. Dr. Pat Carolan of Children's Hospitals of Minnesota will help us demystify fever in this age group. Going back to the mid-70s, there was a search for criteria to find high-risk vs low-risk pediatric fevers. In the original study out of Boston, it was identified that 10% of the patients under age 2, with WBC greater than 15, and a temperature greater than 38.9C, had severe bacteremia. This was the first set of criteria focused on identifying high-risk infants. With the intro of HIb vaccine in the the late 80s-early 90s, and the pneumococcal vaccine in the mid-90s, there is a much lower prevalence of these infections. The few cases that occur now are due to those who have not received or are non-responders to the vaccine. The shift in study of pediatrics has now been to better differentiate high-risk vs low-risk febrile infants. What is considered a fever? The traditional definition of fever is a temperature over 100.4F. Pediatric fevers can be broken down into 3 groups. Those in 0-28 days are high-risk and regardless of a positive RSV or influenza test, get a full work up - including blood, urine, csf, cultures, antibiotics, and admission. What if they are 0-28 days and they have otitis media or RSV? The clinical exam of otitis media in this aged population would be difficult, and even if the clinician had confidence in a focal finding, those at this age group are still at significant risk and would get a full work up. RSV would be unusual in a 2-week old and even if positive , that would be an usual finding, and again these neonates would still get a full work up. The rates of bacteremia in studies have shown that a full work up is warranted. Infants at 3-months are lower-risk, and in general, can usually be managed as outpatients with lab work. Risk for infants in the 2nd month of life is harder to determine and they are the target of risk stratification tools discussed later in this podcast. These are the "tweeners". Initially, assessment of these infants include that across the room pediatric triage triangle. How are they reacting to stimulus? What does their skin color look like? What is their body tone? Have the parents noted whether the infant is engaged in feeding? Are they tachycardiac? Infants can present with fever, but some infants that are septic, can present afebrile or hypothermic. Remember, it is important not to overlook a potential differential diagnosis, including congenital ductal lesions or metabolic abnormalities. CHAPTER 2: Risk stratification tools vary, but utilize biomarkers such as procalcitonin and CRP as key features of the pathways. Each tool mentioned today, PECARN, Stepwise and Rochester, all have high sensitivity and high-negative predictive values. Choosing the appropriate tool depends on the patient population, ability to run specific biomarker tests, and comfort level in the subsequent interpretation. For example, the availability of a facility to run a procalcitonin would determine whether a particular stratification tool could be used. The most recent study, conducted by PECARN or the Pediatric Emergency Care Applied Research Network, is a large, multicenter study that uses procalcitonin, absolute neutrophil count and urine analysis as the base of its pathway. The PECARN is structured as a decision tree, formatted in a way, to quote Dr. Carolan that "helps decision making in the trenches." Differentiating between the terms "serious" vs "invasive" infections. Serious infections include, but are not limited to bacterial, bone and joint infections, and UTIs. Invasive includes pneumococcal meningitis and HIB. In the simplest terms, invasive infections are of greater concern, and is "the stuff we want to treat immediately". Bacterial organisms of concern include: group B strep and gram negative organisms for neonates, pneumococcus and more rarely, HIV at 1-month and older. E.Coli, especially as a uro pathogen and Listeria, though rarer, makes the list of concern as well. An important viral organism of concern is Herpes Simplex Virus, which depending on the facility, is an add on order when running CSF. HSV has 3 main types, the most devistating a CNS infection, which presents with fever and seizures - whether focal or generalized. Pleocytosis, or WBC greater than 16 in CSF, is abnormal in those less than 28-days of age. WBC greater than 10 is abnormal for 2-3 months of age. An absence of pleocytosis does not exclude a central nervous infection by HSV. CHAPTER 3: At 2-months of age, infants that meet low-risk criteria, can be treated as an outpatient - if next day follow-up can be assured. Conservative treatment for those with a UTI that have an abnormal urine and positive biomarker, would get blood cultures, LP and antibiotics. The odds ratio is low, but gram negative CNS infections can be devastating and require extended treatment of antibiotics. The stratification tools, PECARN, Stepwise, and Rochester, help guide practice for these 2-month old infants or "tweeners", but it can still be difficult to decide whether or not to do an LP. There is still a place for practitioner gestalt, and if something feels not quite right, an LP is appropriate. Some infants are brought to the ER with reports of a fever, but upon presentation are afebrile. If a rectal temp performed at home, then it is regarded as a true fever, and the age appropriate work up should be started. Empiric treatment for infants include: Ampicillin and Cefotaxime. Cefotaxime is the go to for 3rd generation cephalosporin, instead of Rocephin, which can cause a rise in bilirubin in young infants. For those under 3-weeks, Acyclovir coverage is added till HSV is ruled out. Vancomycin would be used for those beyond 2-weeks of life with pneumococcus or staph infection with sepsis. Tamiflu is started for infants with positive influenza greater than 2-weeks and under 2-years of age, per CDC recommendations. For those infants who are not vaccinated, the plan of care does not change for those under 3-months or greater that are vaccinated. Intuitively, it would be suggested that they are at higher risk, but there is little data bout this specific group. Thanks for listening.
There are over 100 herpesviruses, and of those 8 affect humans. The two that are most common are the herpes simplex virus type 1 and type 2. HSV-1 and HSV-2 are common skin conditions. If you have HSV-1 or HSV-2, you should not be ashamed or embarrassed. The truth is that this virus affects a considerable portion of the population, and one in five women. Neonatal herpes is a serious condition that can have detrimental effects. The good news is that transmission rates during pregnancy and birth are low. Learn about how the herpes simplex virus can affect you and your baby during pregnancy, what medications are safe to use, and how to prevent transmission to your baby. You can read the full article and resources that accompany this episode by clicking here. For more evidence-based information visit the Pregnancy Podcast website.
Providing the latest research studies into the Herpes Simplex Virus and Revolutionizing the treatment approach to Herpes. Synergy Pharmaceuticals Herpes has created new product development that focuses on viral diseases.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.30.124958v1?rss=1 Authors: Acuna-Hinrichsen, F., Covarrubias-Pinto, A., Ishizuka, Y., Stolzenbach, M. F., Martin, C., Salazar, P., Castro, M. A., Bramham, C., Otth, C. Abstract: Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. The primary infection in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. Under stressful conditions, the virus reactivates, and new progeny is transported anterogradely to the primary site of infection. In late stages of neuronal infection, axonal damage is known to occur. However, the impact of HSV-1 infection on morphology and functional integrity at earlier stages of infection in neuronal dendrites is unknown. Previously, we demonstrated that acute HSV-1 infection in neuronal cell lines selectively enhances the expression of Arc protein - a major regulator of long-term synaptic plasticity and memory consolidation, known for being a protein-interaction hub in the postsynaptic dendritic compartment. Thus, HSV-1 induced Arc may alter the functionality of the infected neurons having an impact on dendritic spine dynamics. In this study we demonstrated that HSV-1 infection causes structural disassembly and functional deregulation in cultured cortical neurons, through protein homeostasis alteration with intracellular accumulation of Arc, and decreased expression of spine scaffolding-like proteins such as PSD-95, Drebrin and CaMKII{beta}. Our findings reveal progressive deleterious effects of HSV-1 infection on excitatory neuronal synapse function and dendritic morphology, supporting the thesis of the infectious origin of neurodegenerative processes. Key words: HSV-1, neurotropic virus, Arc, PSD-95, Drebrin, CaMKII{beta}, dendritic spines, neuronal infection, neurodegeneration. Copy rights belong to original authors. Visit the link for more info
To Your Health With Dr. Jim Morrow: Episode 29: Coronavirus Update and Human Viral Infections Beyond the coronavirus, a number of human viral infections affect our health. Dr Jim Morrow discusses these viruses in this episode of “To Your Health.” In addition, he offers an update on the coronavirus pandemic and discusses the new telemedicine […] The post To Your Health With Dr. Jim Morrow: Episode 29, Coronavirus Update and Human Viral Infections appeared first on Business RadioX ®.
Herpes 101! Learn what herpes actually is, how it works, & the stats on how common it is. Cold sores, oral herpes, genital herpes, do you have herpes?! The whole 9 yards! Let's talk about herpes, baby.
A Rare Reprieve for Texas Death Row Inmate Rodney Reed (0:33)Guest: Griffin Hardy, Communications Manager for Sister Helen Prejean's Ministry Against the Death PenaltyRodney Reed had been scheduled for execution in Texas this week for the rape and murder of a Texas woman in 1996. But a nationwide campaign to save Reed's life, that included Republican politicians and celebrities Kim Kardashian West and Rihanna, succeeded. On Friday night, the Texas Court of Criminal Appeals suspended Reed's death sentence indefinitely and ordered the court that originally tried Reed to consider new evidence in the case. This kind of last-minute reprieve is very unusual in Texas, which leads the nation in executions. Ancient Origins of Modern Board Games (16:22)Guest: Cameron Browne, Associate Professor of Computer Science, Maastricht UniversitySome of my favorite childhood memories are of playing a new board games as a family. My brother-in-law ran a board game rating website, so we tested lots of them. But long before you could look up a game online and see how many stars it got, people passed down games orally or wrote instructions that have long since been lost. In fact, the rules for some of your favorite games may date back centuries. 50th Anniversary of Apollo 12 (32:11)Guest: Mike Joner, Professor of Physics and Astronomy, Brigham Young UniversityYou couldn't miss the 50thanniversary celebrations of Apollo 11 over the summer. Everybody knows Neil Armstrong and Buzz Aldrin were the first to walk on the moon. You ever heard of Pete Conrad and Alan Bean? They landed on the moon just four months later. At this very moment 50 years ago, the crew of Apollo 12 was about to touch down on the lunar surface. So, we're going to pay a little tribute to the men who were 3rdand 4thon the moon. The DC Sniper and Questions of Youth in the Justice System (51:10)Guest: Marsha Levick, Chief Counsel and Founder of Juvenile Law CenterWhen a teenager commits murder, should he face the death penalty? Not according to the US Supreme Court, which, a decade ago, abolished the death penalty for offenders under 18. So, what should happen to that teenager? Is life in prison without the chance of a parole a reasonable sentence? Over the last several years the US Supreme Court has been steadily restricting that sentence for juvenile offenders, too. The latest case to come before the justices involves a particularly high-profile inmate –Lee Boyd Malvo, better known as one of the DC snipers who killed 10 people in a shooting spree back in 2002. Malvo was 17 at the time. The FIDO Project Gives Dogs A Voice (1:10:08)Guest: Melody Jackson, Director, Center for BioInterface Research and Professor at Georgia Tech's College of ComputingIf you've never dreamed of talking to your dog, you're probably lying to yourself. Now, new technology is making that dream a reality. Researchers at the Georgia Institute of Technology are creating new tech that allows dogs to contact humans in case of emergencies their owners face (such as with a chronic illness, an injury, or even an allergic reaction) and speak in ways we can actually understand. For example, a new dog vest is one of several emerging technologies that is programmed with a few phrases that the dog initiates with a tap of their nose. "My owner needs your attention!” and “Please follow me!” are the working messages currently. However the project is still underway and they are excited to continue improving fido's speech. A New Antiviral for Herpes Virus (1:22:49)Guest: Alonzo Cook, PhD, Professor of Chemical Engineering, BYU; Rex Cates, PhD, Retired Professor of Biology, BYU; Mike Alder, BYU Technology Transfer OfficeTwo-thirds of all the people on the planet are infected by the Herpes Simplex Virus 1 –that's the one that causes periodic outbreaks of cold sores. It's incredibly common and, as yet, without a cure or a vaccine. BYU researchers are developing a treatment that comes from a tropical succulent.
New CEO of Squarex, Jack V. Talley discusses the positive results of the phase 2 study on their new investigational drug candidate SQX770, a topical immunomodulator treatment to extend the time between herpes labialis (recurrent cold sores) outbreaks caused by Herpes Simplex Virus 1 or Herpes Simplex Virus 2. Squarex is a clinical-stage pharmaceutical company.
In this episode I cover meningitis.If you want to follow along with written notes on meningitis go to https://zerotofinals.com/medicine/infectiousdisease/meningitis/ or the infectious diseases section in the Zero to Finals medicine book.This episode covers the meningococcal meningitis, meningococcal septicaemia, causes, presentation, investigations, management and complications of meningitis. The audio in the episode was expertly edited by Harry Watchman.
Writer and anti-stigma advocate Rukiat joins Rodecka & Sam to talk about the stigma that comes with a herpes diagnoses and the role it can play in ones sex, love, and dating life. Bae(s) of The Week: Shawné Michaelain Holloway the artist and sex educator who is redesigning the strap on Hoe(s) of the Week: Alex D, Melissa D, Hillary H, Molly Schwartz and Iman S. Self Care Tips: Sam gives a gentle reminder to do your taxes and a nudge to find a therapist when you’re in a good mood. Fuck It (Topic of the Day): Rukiat joins IHU to talk about the stigma that comes with a herpes diagnoses and the role it can play in ones sex, love, and dating life. Points of discussion include: Herpes Simplex Virus 1 v Herpes Simples Virus 2; getting diagnosed with Herpes, treating herpes simplex virus 2, disclosing your diagnosis to partners, celibacy, activism versus advocacy, Lapp the Brand, Why is herpes so stigmatized, herpes symptoms, fear of being undateable, asymptomatic shedding, medication and outbreaks, outbreak triggers, Usher and NBA Young Boy, shutting down ignorance in real life, Black American Twitter versus Black British Twitter & more! HASHTAGS Use #InnerHoeUprising and #Podin to keep up with this conversation on social media and let others know that you are listening. RELEVANT LINKS AND NOTES Preserve This Podcast: http://preservethispodcast.org/ Sam’s guest spot on How’d U Meet: https://apple.co/2UOeW8I STRAPP: http://strapp.shop/ An Article on Shawné: https://bit.ly/2P1frqE SXSW Blaccents Panel: https://soundcloud.com/officialsxsw/sxsw-2019-where-are-the-podcast-blaccents Sex Trivia Sunday April Edition: https://sextriviasundaysapril.eventbrite.com/ Save the Date: PodInLiveNYC @ Von Bar on May 11 2019 @ 4PM Listen to Rukia's Music: https://soundcloud.com/rukiat WEBSITE InnerHoeUprising.com PAY A BITCH Paypal.me/innerhoe https://www.patreon.com/InnerHoeUprising WRITE IN EMAIL ihupodcast@gmail.com SPEAKING GIGS Wanna pay us to speak at your school or conference about sex positivity, black feminism, or the other kinds of topics we discuss on this show? We’d love to! To book us, send us a line to ihupodcast@gmail.com MUSIC Opening: “Queen S%!T” by SheReal https://soundcloud.com/shereal/04-queen-s-t-produced-by Fuck It: “Keeping it Cool Witchu” Chhoti Maa End: “Yeah Yeah” Abstract Fish Co ENGINEERING AND EDITING BY Slamwell Tarly SOCIAL MEDIA Inner Hoe Uprising| IG: @InnerHoeUprising | Twitter: @InnerHoeUprisin Rebecca| IG @thedarkestimeline | Twitter: @rebbyornot |Tumblr: @noneedtomakebeleive Sam | IG & Twitter: @slamridd Travel IG: @carmensamdiego Rukia | IG: @__rukiat #black #woman #sex #feminist #womanist #Comedy #raunchy #queer #STI #STD #herpes
Today we’re talking about curing viruses with Scalar Energy, and we also discuss volatility and interest rates in our current market. If you’re not already familiar with Scalar Energy Healing, I highly recommend that you tune into this show! This healing method has successfully been used on many viruses and pathogenic diseases that the general public believes cannot be cured, such as HIV, Herpes, Ebola, Lyme Disease, and Hepatitis. The best part about Scalar Energy Healing is that it can be used to provide a fast, remote, harmless, and painless treatment process that can heal over 400,000 different pathogens. For anyone that is suffering from any kind of virus, you deserve the shot to get rid of it. I have done this treatment myself and have the test results to prove that it really does work! Tom Paladino, the creator of Scalar Energy Healing, joins me to share what scalar energy is, how it’s able to break down the genetic code of viruses, and why this new way of healing is going to change the world. Financial Advisor, Cheri Blair, also joins me today to give us the scoop on recent volatility in the market, rising interest rates, and the importance of diversifying your portfolio. We Discuss: What Scalar Energy is and how it’s been harnessed into a powerful healing method How Scalar Energy Healing cured me of the HSV-1 (Herpes Simplex Virus 1) How Scalar Energy can treat large groups of people quickly and effectively Why Scalar Energy Healing will be a game-changer in the world of medicine How volatility has recently returned to the current market in a big way Why it’s important to not make emotional decisions in a more volatile market The importance of diversifying your portfolio and staying invested when there’s high volatility Why fleeing the stock market in times of volatility can be more costly in the long run Looking at the fundamentals to gauge what’s going on in the market and economy For the full show notes visit: www.ChangeItUpRadio.com
Life With Herpes https://youtu.be/Fk9oCzIQ_IA Welcome to today's episode. In general when we hear the word herpes, or STD or STI our heart sinks. We become paralyzed and think, no way this is happening to me. Right? We also hear the word herpes and think, what the heck is it or oh I better google that. Since launching Life With Herpes in June of 2017, I’ve heard pretty much everything when it comes to herpes. Just an FYI...nothing is TMI. So if you DM me don’t be afraid to say it and don’t hold back. I’ve heard things like… I don’t want to die from getting herpes! Eww gross the blisters are gross, will they scare? Why me, I feel like my life is over what do I do? Is the itch on my balls the herpes coming on? How did I get it, I never had sex! I’ve been with the same partner for 2 years and now it just showed up, how is this possible? If I have it down there will it show up there? Do any of these sound familiar? You betcha. I had thoughts and questions like these too, except the balls part...lol Our society has done a great job of making us feel like lepers and an even better job of not educating us so this leaves us without knowledge of how to properly take care of the herpes virus and prevent outbreaks as well as prevent transmission. So here it is. Here’s the 101 on Herpes! What is herpes? Herpes is known as the Herpes Simplex Virus or HSV1 or HSV2. HSV1 is most commonly associated with oral herpes and HSV2 is most common in the genital region. Because herpes is a virus it means you will have herpes for the rest of your life. In other words, at this point, there is no cure for herpes. Sorry! When the virus is not active it will lie dormant along your nervous system until it wakes up and decides to rise to the surface of your skin and cause an outbreak. Think of it like a volcano, some are active some are dormant and some you just really don't know when they are going to explode. What does it look like? In some people, they describe their outbreak like a papercut. And some people describe their blister as a liquid filled blister. Some outbreaks are just one blister and other outbreaks can have a cluster of blisters. The blister will take on different appearances depending on if it’s in the infancy stage of the outbreak or if it’s in the healing phase. The beginning can look like a small bump or a cluster of small bumps, then they can fill with fluid or they are open and can look like paper cuts. The final stage is the scab stage where the blister has a small scab on it. Lesions can take the form of; a red spot, a pimple, an ingrown hair, razor burn, and a bug bite. How do I know if I have herpes? The best way to determine if you have herpes is to see a medical professional and get tested. Of the 16.2% of people who have HSV2 80% of them don’t know they have it. That number is unbelievably high and quite scary. Get tested and find out. In so many cases an outbreak goes unnoticed or misdiagnosed basically because we don’t want to admit we have it. Your test results will let you know if you have HSV1 or HSV2. What are some of the symptoms of herpes? There is a long list of herpes outbreak symptoms and for everyone, they will be different. I like to use the example of having a cold. Everyone has a little bit of different symptoms but at the end of the day, it’s a cold. Here are the herpes symptoms: Swollen lymph nodes Swollen glands in your pelvic area, throat or under your arms Exhaustion Headache Body aches Pain around your genitals Inflammation around your genitals Difficult peeing because sores can block the urethra Itching Nerve pain Will I die from herpes? No, you will not die from herpes. Herpes is just a skin disease and that is it. If I’m exposed to herpes how long before it shows up? The typical incubations time is 2-14 days. However, in some people, it can take weeks, months and years before it is noticed. Can I be herpes positive without having an outbreak? No, if you are testing positive for herpes then at some point you’ve had an outbreak. If there is a blood test administered then the test is looking for the herpes antibody. The way our bodies work is when there is a foreign object such as a virus our body goes to work with our fighter T cells to protect us and the result are antibodies. So if we have herpes antibodies then we have the herpes virus and somewhere along the way, we had an outbreak. How do you test for herpes? There are two types of tests, a swab test or a blood test. Typically if a person is showing blisters then the medical provider will swab the blister. If there are no blisters present and it’s a routine check-up there will be a blood draw to look for the herpes antibody. I went into great detail in episode 85. Are Oral Herpes and Genital Herpes different? Yes and no. They are both herpes but they are different strains. At the end of the day they both do the same thing, cause a blister. HSV1 is most common in the oral region and can also be known as oral herpes, fever blisters or cold sores. HSV2 mostly appears in the genital region and known as genital herpes. However, either type, 1 or 2, can go to any spot. What are the signs of genital herpes? Genital herpes can appear anywhere in the genital region. For both men and women it can show up; your butt, your anus, inside of your thighs or below your belly button. For men, you can get an outbreak; on your penis, on your balls, or anywhere in that area. And for women, you can get outbreaks; on your vagina, inside your vaginal canal and even up to your cervix. What are the signs of oral herpes? Oral herpes likes to show up around your mouth. Blisters can appear on the lip or just outside of the lip. Sometimes the outbreak can travel up your face but the outbreak will begin around your mouth. Is a cold sore herpes? Yes, cold sores are the same thing as herpes. If I have oral herpes can I get an outbreak genitally or visa versa? If you have HSV1 and it is orally then you will get outbreaks orally. If you have HSV2 and get outbreaks genitally then you will get outbreaks genitally. A lot of times people ask if they have oral herpes will it show up genitally and the answer is no. The only way that can happen would be if that area was infected with the virus. Wherever you have your outbreaks is where you will continue to have your outbreaks. How is herpes transmitted? Herpes is skin to skin transmission. So when an infected person comes into contact with an uninfected person they can potentially transmit the virus. This can happen with kissing and touching. The virus likes moist wet areas so it is possible for the virus to be transmitted by another vehicle such as a lipstick or sharing utensils or drinks. Can I pass herpes without an outbreak? Unfortunately, herpes can be transmitted without an outbreak. It’s called asymptomatic shedding. Asymptomatic shedding is when the virus decides to shead and the virus pops up to the surface of the skin. There are no symptoms and the infected person has no clue this is going on. At this point, the virus can be passed and transmitted. What sexual acts can transmit herpes? Pretty much any sexual act can transmit herpes. I know...its a real bummer. So vaginal sex, oral sex, anal sex, foreplay, fondling and even masturbation can transmit herpes. How common is herpes? Herpes is so common and I can guarantee you that someone in your family has it too, they’re just not telling you. For HSV1 ⅔ or 217 million Americans have it and for HSV2 ⅙ people or 25 million Americans have it. That's a ton of people so please don’t feel alone. Of the 16.2% of people with HSV2 or genital herpes, 80% don’t even know they have it. How do I get tested for herpes? One of the reasons why herpes is taboo and its becoming an epidemic is because a herpes test is not included in the typical STD check up. A patient specifically has to ask for a herpes test. Not knowing this has become a surprise to many of us who suddenly get test results back and were like what? How did this happen? You can go to planned parenthood or your healthcare provider and ask them for a herpes test. What are the herpes stats? ⅔ or 217 million Americans have HSV1 ⅙ or 25 million Americans have HSV2 25% of women and 20% of men have HSV2 Herpes male to non-herpes female transmission rate is 10% Herpes female to non- herpes male transmission rate is 4% Based on no sex during active outbreaks, non-use of daily antivirals, and non use of condoms Condoms reduce transmission by 30%-50% Daily antiviral suppression reduce transmission by 48% 50% of genital transmission via oral sex is HSV1 References: American Sexual Health Association (ASHA) http://www.ashasexualhealth.org/ Center of Disease Control (CDC) https://www.cdc.gov/ Planned Parenthood https://www.plannedparenthood.org/ WebMD https://www.webmd.com/ Here’s How I Can Support Join our monthly live Herpes Support Group - www.lifewithherpes.com/supportgroup Herpes Outbreak Toolkit - https://lifewithherpes.com/herpes-outbreak-toolkit Emergency Call - https://lifewithherpes.com/emergencycall/ Keep in touch with Alexandra Harbushka www.lifewithherpes.com www.instagram.com/alexandraharbushka www.facebook.com/lifewithherpespodcast www.pinterest.com/lifewithherpes Join The Live With Herpes Community If you are ready to join a community of people who are living with herpes also then you will want to join our slack group. It is FREE and it is a great way to find the support and comfort that you are looking for. Head on over to www.lifewithherpes.com and join our community. You will receive a slack invitation as soon as you sign up. See you in there. Ways You Can Support The Life With Herpes Show If you enjoyed this episode as much as we enjoyed making it for you than a subscribe would be a great idea. Are you a YouTuber? Go ahead and subscribe to the show. It is a way to pay it forward to fellow friends who are living with herpes. When you subscribe it helps the algorithm in YouTube and it helps promote the show. If you are worried about your identity and your friends finding out you subscribed to a herpes channel then change your settings to private. And trust me I totally get it and would want to keep it a secret. Also, when you subscribe you will be notified in your inbox when a new episode is out or when Alexandra is live on Youtube Live. Subscribe Here Are you a podcast listener? Please give the Life With Herpes show a review. It is a way to pay it forward to fellow friends who are living with herpes. You can Subscribe, Rate and Review the show through your iTunes app or on the desktop. Seriously, it helps out a lot more than it is a hassle for you. You see, iTunes has an algorithm that organically promotes the show, so the more ratings and reviews the Life With Herpes Show receives then the higher it gets ranked. This is your way of paying it forward and helping someone find the show who really needs it. Oh, and you can totally use a fake name, so don’t worry about a friend finding you in the iTunes review. Talking about herpes needs to be spread as far and wide as possible. You are totally a part of this movement so THANK YOU! Subscribe, Rate and Review
What Types of Tests are There For Herpes? [video_player type="youtube" style="1" dimensions="560x315" width="560" height="315" align="center" margin_top="0" margin_bottom="20" ipad_color="black"]aHR0cHM6Ly95b3V0dS5iZS9uVDVUNDFTM2pRQQ==[/video_player] The breakdown of herpes tests, false positives and retesting. So maybe you’re wondering if your herpes test came back with a false positive. Or maybe you are wondering if you were even tested for herpes when you did your other STD testing. Or maybe you are just wondering where to even begin. Well here it is, there are 2 types of herpes tests; the culture test and the blood test. I want to make sure you are aware that you have to ask for a herpes test. Just because you got STD/I tested does not mean you were tested for herpes. You specifically have to ask for a herpes test. Not knowing this little bit of crucial information can really cause for some false hope in a clear STD test. Why this is the case is beyond me but I wanted to make sure you knew this essential tidbit. If you are like me then you are probably thinking, with different types of tests how do I know what type is best for my situation and I have to specifically ask for a herpes test? Basically, herpes testing is broken down into 2 categories; symptoms or no symptoms? So let’s talk about herpes symptoms: If you have symptoms like an outbreak with lesions or blisters then most likely your doctor or medical provider will do a culture test or commonly known as a swab test. This usually takes place 48 hours after the lesions appear and one of the downsides is the test results can take up to a week for the results. So if you are experiencing an outbreak and a ton of pain then you may have to wait a week to get a prescription. The good news (if there is good news when we are talking about herpes :-) ) with the culture test is that the virus can be identified either as Herpes Simplex Virus 1 (HSV1) or Herpes Simplex Virus 2 (HSV2). The other piece is that if your culture comes back positive for HSV 1 or 2 then you can know for sure that you have herpes. The good news is you are no longer playing the waiting game even though it is not the answer you were looking for. The Herpes Culture Test Takeaways: Need to have an active outbreak for longer than 48 hours to test The test can determine if it is HSV1 or HSV2 If the test comes back positive you can be sure you have herpes. Now let’s say you don’t have symptoms and you want to get tested for herpes. These types of scenarios would be you slept with someone who has herpes or you are being proactive and in charge of your sexual health are getting tested or maybe your partner just told you that they have herpes. In other words, you don’t have sores or lesions. There are 2 types of blood tests that can be administered the IgM & IgG. Before we go into what the IgM & the IgG tests do I want to go back to 6th-grade science class. Remember what happens when you get a virus? maybe...lol? Well, when something foreign comes into your body that can be harmful like bacteria, viruses and or parasites our immune system kicks into full gear to protect us and keep us healthy. First, your B cells or your white blood cells come to the scene and fight to keep you healthy in return they create antibodies. Then the fight T cells show up to kill off the badly infected cells to prevent the bad cells from reproducing and populating. There is a triage team of cells that show up when the herpes virus shows up. It’s kinda cool. Let’s look at IgM & the IgG blood tests for herpes. The tests are looking for the IgM & IgG antibodies in the blood because the HSV virus does not live in the blood. The difference between the two is the IgG appears soon after infection and stays in the blood for life. IgM is actually the first antibody that appears after infection, but it can disappear after. So the most accurate of the two is the IgG and the IgM is not typically administered. There are 3 reasons why the IgM is not typically administered and they are: IgM can come and go in the body so it may give a false reading and a false time frame of when the person actually contracted herpes The test can’t determine if you have HSV1 or HSV2 and most people in the US have the HSV1 antibody so you could receive a false positive for HSV2 The IgM can sometimes pick up other viruses that are in the herpes family such as chickenpox or mono. Here is the deal with the IgG: The IgG can determine if it is HSV1 or HSV2 If you test positive for HSV than it is accurate The downside is the antibodies have to show up in the system and this can take anywhere from a few weeks to a few months. Every person's body reacts differently. If you test too soon and the antibodies are not yet in the bloodstream then you can receive a false positive and then a few weeks later test positive Is there a test that will tell me if I have oral or genital herpes? Well yes and no. The blood tests, IgM and IgG do not pinpoint if you will have an oral outbreak or a genital outbreak. The IgM & IgG do determine if it is HSV1 or HSV2. The swab tests will pinpoint if it is oral or genital because you have an outbreak and it will also determine if it is HSV1 or HSV2. Typically if you have an oral outbreak then statistically you have HSV1 and if you have a genital outbreak then statistically you have HSV2. However, as we have discussed before the virus can be interchanged and you can become infected with either or both viruses in either or both places. Can I have False Positives on my herpes test? As we discussed earlier it all depends on the antibodies showing up in your system and if you have an actually outbreak with lesions. If you test too soon and the antibodies have not popped up yet then you can get a false reading. Same as if you to a culture test too soon or too late. If you administer the test before the lesions or after they have healed up the most likely you will get a false reading. If A Test Comes Back Negative, Should I Retest? Considering that there are chances of false negatives during any herpes test, it is important to consider a retest, especially if you are experienced lesion or you know you have come into contact with someone who is infected. References: ASHA WebMD Planned Parenthood Here’s How I Can Help Join our monthly live Herpes Support Group - www.lifewithherpes.com/supportgroup Herpes Outbreak Toolkit - https://lifewithherpes.com/herpes-outbreak-toolkit Emergency Call - https://app.acuityscheduling.com/schedule.php?owner=13691061&appointmentType=6092800 Keep in touch with Alexandra Harbushka www.lifewithherpes.com www.instagram.com/alexandraharbushka www.facebook.com/lifewithherpespodcast www.pinterest.com/lifewithherpes Join The Live With Herpes Community If you are ready to join a community of people who are living with herpes also then you will want to join our slack group. It is FREE and it is a great way to find the support and comfort that you are looking for. Head on over to www.lifewithherpes.com and join our community. You will receive a slack invitation as soon as you sign up. See you in there. Ways you can support the Life With Herpes show If you enjoyed this episode as much as we enjoyed making it for you than a subscribe would be a great idea. Are you a YouTuber? Go ahead and subscribe to the show. It is a way to pay it forward to fellow friends who are living with herpes. When you subscribe it helps the algorithm in YouTube and it helps promote the show. If you are worried about your identity and your friends finding out you subscribed to a herpes channel then change your settings to private. And trust me I totally get it and would want to keep it a secret. Also, when you subscribe you will be notified in your inbox when a new episode is out or when Alexandra is live on Youtube Live. Subscribe Here Are you a podcast listener? Please give the Life With Herpes show a review. It is a way to pay it forward to fellow friends who are living with herpes. You can Subscribe, Rate and Review the show through your iTunes app or on the desktop. Seriously, it helps out a lot more than it is a hassle for you. You see, iTunes has an algorithm that organically promotes the show, so the more ratings and reviews the Life With Herpes Show receives then the higher it gets ranked. This is your way of paying it forward and helping someone find the show who really needs it. Oh, and you can totally use a fake name, so don’t worry about a friend finding you in the iTunes review. Talking about herpes needs to be spread as far and wide as possible. You are totally a part of this movement so THANK YOU! Subscribe, Rate and Review
Gross BODcast is a weekly podcast hosted by Katie Rismondo & Jessyca Murphy.FYI, we are NOT medical professionals. We are just two weirdos fascinated by bodily functions who read too much WebMD. This podcast contains some pretty gross content. So, listen at your own risk!
What you need to know about the herpes virus [video_player type="youtube" style="1" dimensions="560x315" width="560" height="315" align="center" margin_top="0" margin_bottom="20" ipad_color="black"]aHR0cHM6Ly95b3V0dS5iZS9BLXc1WGkybHRFTQ==[/video_player] Life With Herpes Welcome to today’s episode of Life With Herpes. As always I am thrilled to have you here with me, and I am thrilled to be doing whatever it is you are doing. Today I want to get specific and nitty-gritty about viral shedding. This is a question I see a lot, and I also see it become the root to a lot of the questions I see so I thought I would get as detailed as possible when it comes to viral shedding. So let’s start from the beginning. What is Viral Shedding? According to Wikipedia (because I had to look it up lol), The term is used to refer to shedding from a single cell, shedding from one part of the body into another part of the body, and shedding from bodies into the environment where the viruses may infect other bodies. Let me put this into layman's terms; the virus is just like any other part of our body that wants to shed or get rid of waste. In other words, the virus pops up to the surface of your skin, and it is contagious at that time. What are the symptoms or signs of viral shedding? Viral shedding is asymptomatic which means there are no symptoms or signs. Unlike when we get outbreaks we have tingling, or pain, or itching or another type of the trigger that let us know we have an outbreak. When viral shedding occurs, the person has no idea that is happening. The good news is there is no outbreak or swollen lymph nodes or any other symptoms we have to deal with when we get outbreaks. But the bad news is you don’t know it is happening, so it is hard to protect your partner or give them heads up. The only way to know if you are contagious and your herpes virus has decided to shed would be to go to the doctor and have a medical professional swab your genital or oral area. This is a waste of everyone's time, money, and energy because by the time you would get your results back your contagious window would be closed. Are there times when viral shedding occurs? Unfortunately, we cannot predict when it happens. It is not like it’s a seasonal thing like the flu or a monthly thing like a period. It just happens. However, there is some good news. According to the Center for Disease Control (CDC) people with Herpes Simplex Virus 1 (HSV1) viral shedding only occurs 5% of the time. If you have Herpes Simplex Virus 2 (HSV2), then the virus sheds 6-10% of the time during the first year and then decreases after that. Why the first year? Most likely because your body is trying to adjust to the newest member of the family. Your body is trying to fight it off and protect itself from getting sick or having an outbreak. As time continues in most people, your body builds up immunity, and you will have fewer outbreaks. So it makes sense that you would have less viral shedding. Do antivirals help with reducing viral shedding? Yes, they actually do so this is great news. Studies have shown that daily use of Valtrex also reduces the proclivity of the virus to “shed”, or be contagious as often. Its use appears in studies to reduce the viral shedding periods by 50%. Antivirals such as Valtrex and Valacyclovir inhibit the development of the virus or in layman's terms prevent an outbreak from occurring. Antivirals do not cure herpes, guarantee that there will not be an outbreak or prevent viral shedding. They suppress the virus so that it stays dormant in your body. What are the best methods to prevent passing herpes to my partner? There is no magic pill or guarantee that herpes will not be transmitted. Unfortunately, the virus is very contagious and for it to survive it needs to continue to find more hosts. Otherwise, we would not be dealing with herpes thousands of years down the road. It would have died out like the dinosaurs. Two ways you can prevent passing herpes to your partner are condoms and a daily antiviral. However, this is not a guarantee. For example, when using a male condom, there are still areas of the genital area that are not covered, and body parts will touch other exposed body parts during vaginal sex, oral sex, and anal sex. Yes, condoms cover a good portion and help protect you, but they are not going to cover the area completely. And as you have learned from reading this article taking the daily antiviral will lessen your chance of having an outbreak as well as lessen your chance of viral shedding. So using them combined will help protect your partner. Keep in touch with Alexandra Harbushka www.lifewithherpes.com www.instagram.com/alexandraharbushka www.facebook.com/lifewithherpespodcast www.pinterest.com/lifewithherpes Join the community If you are ready to join a community of people who are living with herpes also then you will want to join our slack group. It is FREE and it is a great way to find the support and comfort that you are looking for. Head on over to www.lifewithherpes.com and join our community. You will receive a slack invitation as soon as you sign up. See you in there. Ways you can support the Life With Herpes show? If you enjoyed this episode as much as we enjoyed making it for you than a subscribe would be a great idea. Are you a YouTuber? Go ahead and subscribe to the show. It is a way to pay it forward to fellow friends who are living with herpes. When you subscribe it helps the algorithm in YouTube and it helps promote the show. If you are worried about your identity and your friends finding out you subscribed to a herpes channel then change your settings to private. And trust me I totally get it and would want to keep it a secret. Also, when you subscribe you will be notified in your inbox when a new episode is out or when Alexandra is live on Youtube Live. Subscribe Here Are you a podcast listener? Please give the Life With Herpes show a review. It is a way to pay it forward to fellow friends who are living with herpes. You can Subscribe, Rate and Review the show through your iTunes app or on the desktop. Seriously, it helps out a lot more than it is a hassle for you. You see, iTunes has an algorithm that organically promotes the show, so the more ratings and reviews the Life With Herpes Show receives then the higher it gets ranked. This is your way of paying it forward and helping someone find the show who really needs it. Oh, and you can totally use a fake name, so don’t worry about a friend finding you in the iTunes review. Talking about herpes needs to be spread as far and wide as possible. You are totally a part of this movement so THANK YOU! Subscribe, Rate and Review More Episode Resources How can I help you? Tell me in a free 15 minute chat! The Herpes Outbreak Toolkit (use the promo code PODCAST) Join The Life With Herpes Community Life With Herpes YouTube channel DoTerra’s essential oils
I detta avsnitt pratar vi om Herpes Simplex Virus, ett listigt virus som är den vanligaste orsaken till munsår men som kan ställa till mycket värre saker för vissa. Till vår hjälp har vi Petra Boumedienne, Kostrådgivare och yogalärare, som blev expert på just HSV då hon själv blir allvarligt sjuk när det bryter ut. […]
Steven C. Kaufman, MD, PhD
MDS presents the latest research and findings from the field of Movement Disorders. Abstracts of articles from the Society Journal, Movement Disorders, are taken from the January 2014 (Vol. 29, Issue 1) issue.
Areas of discussion include Biology of HSV Infection - Organism Characteristics, Epidemiological Information (HSV-1, and HSV-2), Pathogenesis (Modes of Transmission and Disease Progression), Diagnosis, Treatment Options, and Prevention Approaches. Speaker: Denise Heaney, Ph.D., Roche Diagnostics
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 14/19
Herpesviren umfassen eine große Gruppe von human- sowie tierpathogenen Erregern. Auf Grund ihrer hohen Durchseuchungsrate und Fähigkeit zur Etablierung einer latenten Infektion stellen humane Herpesviren vor allem für immunsupprimierte Patienten eine ernsthafte Bedrohung dar. Deshalb ist eine umfassende Aufklärung des viralen Replikationszyklus für die Entwicklung von antiviralen Therapiestrategien zwingend erforderlich. Besonders die membran-assoziierten Vorgänge der Virionmorphogenese - primäre Umhüllung an der inneren Kernmembran mit darauffolgendem Verlust der Virushülle an der äußeren Kernmembran sowie sekundäre Umhüllung an cytoplasmatischen Membranen - sind nur unvollständig entschlüsselt. Um das komplexe Zusammenspiel der viralen Proteine während des Replikationszyklus an den verschiedenen zellulären Membranen aufzudecken, wurde im Rahmen dieser Arbeit eine genomweite Analyse der Protein-Protein-Interaktion (PPI) der durch Herpes simplex-Virus 1 (HSV-1) kodierten Membranproteine durchgeführt. Außerdem lieferte die Identifizierung von PPI zwischen dem HSV-1 Proteom und Untereinheiten der zellulären ESCRT-Maschinerie (endosomal sortingcomplex required for transport) weitere Belege für die Ausbeutung von Wirtsfaktoren durch das Virus zur Knospung der Partikel. Zur Detektion der genomweiten PPI sowohl intraviral als auch zwischen Virus und Wirt wurde das Hefe-2-Hybridsystem (Y2H) im Hochdurchsatz angewandt. Beide Datensätze konnten eine Vielzahl neuer PPI aufdecken und somit eine solide Grundlage für Interaktionsnetzwerke und zukünftige funktionale Studien schaffen. Auch wurde duch das breite Interaktionsspektrum des Virus mit den z.T. funktionell redundanten ESCRT-Proteinen erneut veranschaulicht, wie die Nutzung flexibler Strategien zur Stabilität des HSV-1 beiträgt. Anhand der Y2H-Analysen wurde ein virales Membranprotein als interessanter Kandidat zur funktionalen Charakterisierung ausgewählt. Glykoprotein M (gM/UL10) von HSV-1 ist ein Typ-III Transmembranprotein, das während der Infektion in verschiedenen Membrankompartimenten lokalisiert. Obwohl evolutionär konserviert, ist es zumindest für HSV-1 nicht-essenziell und seine molekulare Funktion unklar. Auch die funktionale Relevanz einiger potenzieller trafficking Motive von gM ist noch nicht aufgeklärt. In dieser Studie konnte gezeigt werden, dass das targeting von gM zum trans-Golgi Netzwerk (TGN) unabhängig von anderen viralen Faktoren sowie seinen potenziellen C terminalen trafficking Motiven erfolgt und keiner Homooligomerisierung bedarf. Erstaunlicherweise führt die Deletion der C-terminalen Domäne von gM (gMΔC) zu seiner Retention im ER, wohingegen der Vorwärtstransport durch eine kurze, nicht-verwandte Sequenz wiederhergestellt wurde. Demzufolge enthält die C-terminale Domäne von gM wahrscheinlich keine Sequenzinformation für das targeting vom ER zum Golgi-Apparat, jedoch scheint die Faltung und Integrität des Proteins dafür von Bedeutung zu sein. Im Kontext der Virusinfektion führte die Deletion der C-terminalen Domäne von gM (HSV-1 gMΔC) zur Akkumulation von nicht-umhüllten Partikeln im Cytoplasma, verminderter Freisetzung von Viruspartikeln und in ihrer Infektiosität beeinträchtigten reifen Virionen. Alle Effekte wurden durch eine Revertante wieder aufgehoben und sind demnach spezifisch. Im Gegensatz dazu zeigten zwei zusätzliche Mutanten, HSV-1 ΔgM mit einem frühzeitigen Stoppcodon an Position 3 von UL10 und gMΔac ohne potenzielle trafficking Motive, Wildtyp-ähnliche Wachstumskinetiken. Daraus lässt sich schließen, dass zwar gM entbehrlich ist, gMΔC jedoch einen dominant-negativen Effekt ausübt. Daher wird eine Beteiligung der N-terminalen Bereiche von gM (Aminosäuren 1-361) an der Rekrutierung von viralen und/oder zellulären Faktoren zum Ort der sekundären Umhüllung postuliert. Diese Daten enthüllen neue unbekannte Eigenschaften von HSV-1 gM.
College Academy of Research, Scholarship, and Creative Activity
The study of Herpes, how it affects you and how you can contact it.
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 04/06
Herpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus that infects humans and, after a primary lytic infection, establishes lifelong latency in the sensory neurons of the trigeminal ganglia (TG). HSV 1 latency is accompanied by a chronic immune cell infiltration of the TG, the infiltrate being mainly composed of CD8+ T cells. These T cells are believed to control viral latency, but cellular and viral factors like viral microRNAs are also considered to play a crucial role in the establishment and maintenance of viral latency. In the present work, it was investigated whether the tissue-infiltrating T cells are clonally expanded, which would indicate that these T cells are activated by antigen. By applying complementarity determining region 3 (CDR3) spectratyping and immunohistochemistry, several clonal expansions were identified in the TG-resident T cells. In addition, several T cells were present that seemed to be unspecific bystander T cells. Strikingly, some expanded T cell clones were present in the right and left TG of the same individual. This strongly suggests that similar antigens are present in both TG and that the infiltration of immune cells to the TG is driven by antigen. The morphology of the TG was investigated by immunohistochemistry and in situ hybridiza¬tion. Analysis of the distribution of T cells throughout the TG provided puzzling results: unexpectedly, most neurons surrounded by T cells did not harbour the only known prominent transcript during latency, the latency associated transcript (LAT). Whether these neurons do actually harbour latent virus was addressed by a combination of LAT in situ hybridisation, T cell immunohistochemistry, and single cell analysis of laser microdissected sensory neurons by PCR. This analysis revealed that only LAT+ neurons were harbouring HSV 1 DNA and viral microRNAs. Also, mRNA for a viral gene product was only detected in LAT+ neurons. All analysed LAT– neurons were devoid of viral microRNAs and DNA of HSV 1. DNA of HSV 2 or varicella-zoster virus (VZV) was not detected in any of the excised neurons. Alto¬gether this indicates that in the vast majority of infected human neurons, HSV 1 latency is not directly controlled by T cells, but rather by cellular or viral factors like the miRNAs. Our data suggest that CD8+ T cells only come into action if these mechanisms are overrun.
Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 04/06
Thu, 10 Nov 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/14375/ https://edoc.ub.uni-muenchen.de/14375/1/Ott_Melanie.pdf Ott, Melanie ddc:540, d
David Knipe is the Higgins Professor of Microbiology and Molecular Genetics at Harvard Medical school. A virologist, Dr. Knipe focuses his research efforts on the herpes simplex virus 2 (HSV-2) – the virus we have to thank for genital herpes. An astonishing 20% of Americans have been infected with HSV-2, and whether they’ve had a recognizable outbreak of sores or not, they can still carry the virus. Once you contract the HSV-2 it lays low in your nerve cells, waiting for the right moment to create watery blisters that eventually burst and release more virus particles. Dr. Knipe is interested in how the cells lead these two, very different lives: quiet and quiescent inside the nerve cell and loud and lytic in the epithelium on the surface of the body. Genital herpes is no picnic, but the effects of HSV-2 infection are worst in people with depressed immune systems and in newborns; babies who pick up the virus during birth may suffer from neurological damage, brain damage, or even death. There is no cure for genital herpes, and no means of getting rid of HSV-2, only ways of managing outbreaks. But there is some hope of relief; Dr. Knipe’s lab has developed a vaccine that will enter the trial phase soon. In this interview, I asked Dr. Knipe about how he got interested in viruses, about the vaccine he’s developed and who could hope to benefit from it, and why it’s taken science so long to develop a vaccine for this extremely common disease.
Objectives: To determine trends in the prevalence and aetiological distribution of genital ulcer syndrome (GUS) in a cohort of female bar workers and to assess factors associated with these trends.Methods: An open cohort of 600 women at high risk of HIV and sexually transmitted infection (STI) was offered screening and treatment for STI at 3-month intervals. The prevalence of GUS and associated aetiological agents (Herpes simplex virus (HSV), Treponema pallidum and Haemophilus ducreyi) were monitored over 27 months through clinical examination, dry lesion swabbing and multiplex polymerase chain reaction. The effects of HIV status and other factors on the prevalence trends of STI were assessed.Results: A total of 753 women were recruited into the cohort over 10 examination rounds. At recruitment, the seroprevalence was 67% for HIV and 89% for HSV type 2 (HSV-2). During follow-up, 57% of ulcers had unknown aetiology, 37% were due to genital herpes and 6% to bacterial aetiologies, which disappeared completely in later rounds. The absolute prevalence of genital herpes remained stable at around 2%. The proportion of GUS caused by HSV increased from 22% to 58%, whereas bacterial causes declined. These trends were observed in both HIV-negative and HIV-positive women.Conclusions: The changes observed in the frequency and proportional distribution of GUS aetiologies suggest that regular STI screening and treatment over an extended period can effectively reduce bacterial STI and should therefore be sustained. However, in populations with a high prevalence of HSV-2, there remains a considerable burden of genital herpes, which soon becomes the predominant cause of GUS. Given the observed associations between genital herpes and HIV transmission, high priority should be given to the evaluation of potential interventions to control HSV-2 either through a vaccine or through episodic or suppressive antiviral therapy and primary prevention.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 06/19
Das epitheliale Zelladhäsionsmolekül EpCAM ist in der Tumorentstehung von Plattenepithelkarzinomen über- oder de novo exprimiert. Zudem korreliert die EpCAM-Expression in Tumorzellen positiv mit Proliferation und Entdifferenzierung. Es wurde in Vorarbeiten ein 1100 bp epcam-Promotorfragment kloniert, das spezifisch in EpCAM-positiven Zellen transkriptionell aktiv ist und durch TNFα in der Promotoraktivität reprimiert wird. In meiner Arbeit untersuchte ich, ob das 1100 bp epcam-Promotorfragment zur gezielten heterologen Genexpression geeignet ist. Zu diesem Zweck wurden drei Proteine ausgewählt: Grünes Fluoreszenz Protein (GFP), TNF receptor associated death domain Protein (TRADD) und Herpes Simplex Virus 1 Thymidinkinase (HSV1-TK). GFP diente der Visualisierung der Promotoraktivität im Fluoreszenzmikroskop. TRADD sollte die Apoptose in EpCAM-positiven Tumorzellen induzieren. Mit Hilfe der spezifischen Expression der HSV1-TK in EpCAM-positiven Zellen sollten Tumorzellen für Ganciclovir sensitiviert werden. Eine Therapie mit Ganciclovir sollte das Absterben der Tumorzellen bewirken. Die heterologe Genexpression wurde an einem zellulären Modellsystem von EpCAM-positiven und EpCAM-negativen HEK293 Zellen getestet. Dabei zeigten EpCAM-positive Zellen eine deutliche GFP-Expression, während EpCAM-negative Zellen sporadisch eine minimale Fluoreszenzintensität aufwiesen. Die EpCAM-spezifische Expression von GFP konnte im Immunoblot bestätigt werden. Um den Zusammenhang zwischen EpCAM- und GFP-Expression zu veranschaulichen, wurden die Ergebnisse der durchflusszytometrischen Messungen der EpCAM-Oberflächenexpression mit der GFP-Fluoreszenz verglichen. Damit konnte im zellulären Modellsystem von EpCAM-positiven und EpCAM-negativen HEK293 Zellen gezeigt werden, dass die epacm-Promotoraktivität zu einer heterologen Genexpression von GFP führt. Das zelluläre Modellsystem von EpCAM-positiven und EpCAM-negativen HEK293 Zellen wurde auf die Expression weiterer funktioneller Gene untersucht. Für das Funktionsgen TRADD konnte dabei weder eine EpCAM-spezifische heterologe Genexpression in der RT-PCR noch im Immunoblot nachgewiesen werden. In beiden Untersuchungen führten die Positivkontrollen zu einem Nachweis von TRADD. Da TRADD über komplexe Signalwege zur Bildung von TNFα führen kann, findet möglicherweise eine Inaktivierung des epcam-Promotors durch TNFα statt. Die heterologe Genexpression von HSV1-TK unter der Kontrolle des epcam-Promotors konnte im zellulären Modellsystem in der RT-PCR nachgewiesen und auf die EpCAM-positive Tumorzelllinie SKBR3 übertragen werden. Durch die Genexpression von HSV1-TK wurden EpCAM-positive HEK293 Transfektanten sensitiv gegenüber einer Behandlung mit Ganciclovir und zeigten eine deutlich reduzierte metabolische Aktivität im MTT-Ansatz bei Ganciclovirgabe. Dabei gewonnene Erkenntnisse wurden an der EpCAM-positiven Tumorzellinie SKBR3 bestätigt. Zusammengefasst konnte gezeigt werde, dass die heterologe Genexpression von HSV1-TK unter der Kontrolle des epcam-Promotors zu Ganciclovirsensitivität in EpCAM-positiven Zellen führte, jedoch nicht in EpCAM-negativen Zellen. Somit ist es denkbar, das 1100 bp epcam-Promotorfragment für die therapeutische Genexpression letaler Gene zur Elimination EpCAM-positiver Tumorzellen zu verwenden.
© 2020-2025 Ivy Podcast Discovery LLC
