Podcasts about Crystallography

scientific study of crystal structure

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Best podcasts about Crystallography

Latest podcast episodes about Crystallography

Inside the Bradfield Centre
The Cambridge Structural Database for Crystallography

Inside the Bradfield Centre

Play Episode Listen Later Jan 14, 2025 42:10


We learn all about Crystallography in this week's episode with Suzanna Ward, Head of Data and Community at The Cambridge Crystallographic Data Centre (CCDC) – a non-profit organisation whose mission is to advance chemistry and crystallography for the public benefit.CCDC was created by Dr Olga Kennard OBE FRS and J D Bernal who believed the collective use of data would be beneficial and wanted to collect data and making it accessible, transform the data into knowledge banks, and generate new insights.We learn about the structural database and how researchers use it, and how their work now fosters innovation globally.It's also a great story of how tech advancement has changed the Cambridge Structural Database (CSD) over the years, and their support of the next generation of scientists. And we think this is the first episode where knitting needles have been referenced.Produced by Cambridge TV Hosted on Acast. See acast.com/privacy for more information.

Love & Light Live Crystal Healing Podcast
Amethyst Meaning | Origins, Structure, Energy & Astrology [Crystal Confab Podcast]

Love & Light Live Crystal Healing Podcast

Play Episode Listen Later Oct 7, 2024 55:00 Transcription Available


Join Adam Barralet, Ashley Leavy, Kyle Perez, and Nicholas Pearson in Episode #2 of the Crystal Confab Podcast as they discuss all-things Amethyst, including: Similarities & differences of Amethysts from different localities Getting back to basics with simple crystal practices Crystallography and twinning and their effects on Amethyst energy Amethyst and Jupiter Retrograde   Tune in now and dive into the magical world of Amethyst!     Podcast Episode Transcript: Crystal Confab Podcast Introduction: Are you just starting with crystals? Or maybe you have a whole collection but aren't sure how to use them? Join 4 crystal nerds, healers, workers, and lovers for crystal confab, a casual chat about all things crystals. Kyle Perez: Hello, and welcome to crystal confab, where we confab about crystals. I'm Kyle, the crystalline mage, and I have with us Adam Barralet, Nicholas Pearson, and Ashley Levy. And we are going to dive into amethyst, which I think we can all agree is an essential crystal and mineral for anyone working in and around crystals and minerals. I have, been blessed with, working with amethyst since I was a little kid when I was gifted my first piece from my grandmother. I think that's probably a story that's quite similar for everyone, whether it's walking into a crystal shop, whether it's being gifted a piece, whether it's finding a piece. I think Amethyst is often our first, and I'm excited to dive in with all of you about what Amethyst is amazing for in different ways. Maybe you haven't thought about it before, and maybe it will confirm the way you do work with amethyst. Adam Barralet: I love what you're saying, Kyle, about it being your first crystal because it was my first crystal as well. When I walked into a crystal shop, that's what I bought. And then I got a little sheet of paper that told you what to do with each crystal, and then that kind of spiraled out of this top mess than it is today. But, actually, Nicholas, was do you remember your first crystal? Nicholas Pearson: Yeah. I know mine really intimately. It's a piece of quartz that my grandfather gave me. I was you know, like a lot of us, I picked up rocks everywhere I went as a kid. I've never outgrown that, by the way, as Ashley can attest. And, my my grandmother collected, like, vintage turquoise jewelry. So, like, I just had this fascination with rock and gem, and my grandfather gave me a piece of quartz from Hot Springs, Arkansas, and that in no uncertain terms, it changed my life 30 plus years ago. Ashley Leavy: I have a similar story, of course, but my first crystal was fluorite. My grandfather was a huge mineral collector, and he specifically collected fluorite from Cave in Rock, Illinois in Southern Illinois, here in the Midwest in the US. And that fluorite in particular is so beautiful, displays this amazing cubic habit, fantastic color zoning, and he was so into it. And I can remember sitting in his office for hours while he would tell me about all these crystals. And when I was 8, I actually went to he had, like, a little cabin property in Southern Illinois, and I went down to visit for spring break over school. And he took me to Cave and Rock. And although I'm pretty sure that mine had recently closed at that time, and that would have been back in the, like, early to mid-nineties because mold. We went and looked through the, like, dump pile of rocks that they had pulled out, and we actually found some fluorite. And I still have that piece of fluorite today, and it is my favorite stone. It's pretty rough and ready. It's not like a gorgeous piece, but it's so so special. Adam: I love that. I love that. Now today we're talking about amethyst, obviously. And I love people who are watching or listening to let us know in the comments what your first crystal was. But obviously, amethyst is found in many locations around the world, and that's gonna impact identity, I'm guessing.

Under the Surface Podcast
7. On Being The First [Second?]

Under the Surface Podcast

Play Episode Listen Later Aug 22, 2024 45:24


This next episode of Under the Surface has us speaking to crystallographer Eric Larson. In episode 7, as you'll hear, Eric's a little nervous about having his thoughts committed to ‘perpetuity.' But, as you'll also hear, he does a great job. As our first second structural biologist on the show, he tells us about how he got into the field, the very real logistical challenges of working in industry, and his evocative description of what it feels like to peek ‘behind the veil' and be the first on the planet to observe the structure of a previously unknown protein. It's a magical episode This episode was recorded live in Montreal at our 2024 UGM.

Robert Edward Grant - Think Tank
030 - Veda Austin

Robert Edward Grant - Think Tank

Play Episode Listen Later May 21, 2024 142:26


In this captivating episode, Robert, joined by guest expert Veda Austin, delves into the fascinating world of water's transformative powers and scientific mysteries. Veda, a multifaceted water researcher, speaker, mother, artist, and writer, has spent a decade capturing the essence of water through her photography. She regards water as a manifestation of intelligence intricately linked with every life form on Earth and beyond. Her work with crystallographic images uncovers water's consciousness and interactions with thoughts and creation, conveying a message of hope and inclusivity. During the discussion, Veda shares insights from her research into the crystalline structures of water, discussing how environmental factors and human emotions influence these. She also shares a harrowing story about a car crash that profoundly changed her life, adding a deeply personal dimension to the discussion. Robert contributes by weaving in concepts from his studies in mathematics and physics, focusing on how geometric and fractal patterns manifest in natural systems. The conversation broadens to encompass the synergy between science and art, underscoring the importance of interdisciplinary approaches in unveiling new facets of the natural world and the philosophical impacts of perceiving water beyond its tangible properties. Veda extends her passion by educating children in primary schools, combining water science with art to foster a connection with water's living systems. She shares her insights through interviews and podcasts, advocating for a deeper appreciation of water as the foundation of life. Robert and Veda enrich the conversation with personal stories from their research adventures, bringing complex scientific concepts closer to a broad audience. This episode is more than a conversation about water; it represents a profound exploration of how nature's complexities can spur innovation across various disciplines and reshape our understanding of the universe. Books by Robert Edward Grant https://bit.ly/3MvlXVJ Connect with Veda Austin Website: https://bit.ly/4aHLe8G Instagram: https://bit.ly/3J9clxX YouTube: https://bit.ly/4aHJyw5 Connect with Robert Grant: YouTube - https://bit.ly/3XLP3U6 Instagram - http://bit.ly/3WvjXPD Facebook - https://bit.ly/3kI0tKt Website - http://bit.ly/40173M3 Subscribe to the Robert Edward Grant Podcast: Spotify - https://spoti.fi/3DdnMSv Apple Podcast - https://apple.co/3iYjt6X YouTube - http://bit.ly/40dm2Tt  

Soul Slumber Party
Water is Communicating - Veda Austin

Soul Slumber Party

Play Episode Listen Later Feb 20, 2024 64:26


Water researcher, Veda Austin, explores the idea of water being able to communicate and being the source of connecting all things. We delve into the idea of spirit communicating through water, water connecting us to those who have passed on, being used for healing, solving mysteries, storing information through time, and so much more. Through crystallography we are able to see her repeatable experiments and learn how we can contribute to this incredible research by using her simple freezing method in our own homes. Veda Austin (pdf, workshops, and book)https://www.vedaaustin.comhttps://www.instagram.com/vedaaustin_water?igsh=bzJrNWx6MTR5YnM4Soul Slumber Party Social Mediahttps://www.instagram.com/soulslumberparty?igsh=bGp4MWh5b2dqd2Fw&utm_source=qrhttps://www.tiktok.com/@soulslumberparty?_t=8igLDS7zQKZ&_r=1https://www.facebook.com/profile.php?id=61551853726061&mibextid=LQQJ4dKaren Disapproves Social Mediahttps://www.instagram.com/karen.disapproves?igsh=MW1lZGhxZ2M2ZHB5MA%3D%3D&utm_source=qrhttps://www.tiktok.com/@karen.disapproves?_t=8igLAgCjGr0&_r=1Show Inquiries soulslumberpartypod@gmail.com

Bringing Chemistry to Life
AI and the man catalyzing a bio-revolution

Bringing Chemistry to Life

Play Episode Listen Later Dec 20, 2023 34:51


Protein biology has always been grounded in the relationship between structure and function but how we determine structure has changed dramatically. While it's still common to crystallize a protein for X-ray diffraction and then back calculate its structure, supercomputing-powered, AI-driven tools have revolutionized approaches to getting a protein structure and engineer proteins for uses such as biocatalysis. Amazing right, but how? By using wet lab data to train and then compute, protein structure based on their sequence alone, which is why talking with this episode's guest is so interesting. In this episode, Dr. Ahir Pushpanath, Enzyme Technology Innovation Lead at Basecamp Research, explains his passion for gaming as the reason he got interested in this unique computational approach to chemical catalysis. He takes us through the field's fascinating history, recent breakthroughs, and their immense potential. You'll hear about the intersection of his personal mission to provoke a bio-revolution with his company's mission to combine nature and AI. Today at Basecamp Research, Ahir and his team are working to remove global bias from protein-specific AI training sets by collecting samples and data from diverse locations, but their primary focus is to understand the why of protein evolution. Ultimately, they hope to someday be able to help make a protein for every conceivable function by incorporating environmental pressure aspects into their sequence/structure/function AI models. Related episodes: S4 : E3 Chemistry, Computers, and HumansS2: E5 Questioning the limits of Moore's law Other episodes on catalysis:S3:E2 Making impossible moleculesS2:E1 Chemistry: a modern American dreamS2: E3  Rethinking catalysis Bonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more. View the video version of this episode on www.thermofisher.com/chemistry-podcast.  A free thank you gift for our listeners! Visit the episode website and request your free Bringing Chemistry to Life t shirt. Use Podcast Code:  2023wrap in December 2023 or Ba++ery in January 2024. Share your feedback with us! Email helloBCTL@thermofisher.com About Your HostPaolo Braiuca grew up in the North-East of Italy and holds a PhD in Pharmaceutical Sciences from nearby esteemed University of Trieste, Italy. He developed expertise in biocatalysis during his years of post-doctoral research in Italy and the UK, where he co-founded a startup company. With this new venture, Paolo's career shifted from R&D to business development, taking on roles in commercial, product management, and marketing. He has worked in the specialty chemicals, biotechnology, and pharmaceutical markets in Germany and the UK, where he presently resides. He is currently the Director of Global Market Development in the Laboratory Chemicals Division at Thermo Fisher Scientific™ which put him in the host chair of the Bringing Chemistry to Life podcast. A busy father of four, in what little free time he has, you'll find him inventing electronic devices with the help of his loyal 3D-printer and soldering iron. And if you ask him, he'll call himself a “maker” at heart.

Wisdom from the Earth and Sky with Heather Ensworth, Ph.D.
Interview with Veda Austin: Water, Water Crystallography and Consciousness

Wisdom from the Earth and Sky with Heather Ensworth, Ph.D.

Play Episode Listen Later Sep 8, 2023 102:31


Veda Austin's website: https://www.vedaaustin.com/ Veda Austin's Facebook page: https://www.facebook.com/waterresearc... Veda's bio: Veda is a water researcher, public speaker, mother, artist and author. She has dedicated the last 10 years observing and photographing the life of water. She believes that water is fluid intelligence, observing itself through every living organism on the planet and in the Universe. Her primary area of focus is photographing water in its ‘state of creation', the space between liquid and ice. It is through her remarkable crystallographic photos that water reveals its awareness of not only Creation, but thought and intention through imagery. Heather's website: https://www.risingmoonhealingcenter.com/ To become a patron: https://www.patreon.com/heatherensworth/

Cryptopedia - A Paranormal Podcast
Cryptid Lost Media - Bring the Thunder - 139

Cryptopedia - A Paranormal Podcast

Play Episode Listen Later Aug 14, 2023 97:57


I hope you're ready to hear John talk about Ontology and falsifiability for half an hour this week because that's what you'll get.  Brandon and John explore the concept of lost media concerning cryptids, revisiting a topic from this podcast's past.   Merch: https://www.etsy.com/shop/cryptopediamerch Discord: https://discord.me/cryptopediacast Patreon: https://www.patreon.com/user?u=14015340 Youtube (Videos have [questionable] captions!): http://youtube.cryptopediacast.com/ --- The Guide to Cryptid Lost Media : r/Cryptozoology The Lost Media Wiki O parádivé Sally aka "Clock Man" (found Czech animated short film; 1976) - The Lost Media Wiki Cracks aka "Crack Master" (found animated "Sesame Street" short; 1975) - The Lost Media Wiki Nonexistent Objects (Stanford Encyclopedia of Philosophy) Karl Popper (Stanford Encyclopedia of Philosophy) ThunderbirdPhoto - YouTube  The Cryptid Lost Media Iceberg - Truth is Scarier Than Fiction Tombstone Epitaph Article Committee for Skeptical Inquiry Thunderbirds SAGA. May 1963. Thunderbird art by John McDermott | A classi… | Flickr Weird Arizona  - Thunderbird Tombstone Thunderbird Photo| Lost Media Wiki The Citizen, May 31, 1901 Prasad, Deepasri, and Wilma A. Bainbridge. "The Visual Mandela Effect as evidence for shared and specific false memories across people." Psychological Science 33.12 (2022): 1971-1988. Jack Pearl Author Bio http://www.strangemag.com/strangemag/strange21/thunderbird21/thunderbird6_21.html Ivan T. Sanderson - Wikipedia Abominable Snowmen Index A New Routine Tool?: Direct Methods in Crystallography. M. M. Woolfson. Oxford University Press, New York, 1961. viii + 144 pp. Illus. 30s. | Science Bigfoot at 50 Evaluating a Half-Century of Bigfoot Evidence Two feet from Clearwater's past, father's funny legacy leaves a deep impression  Ancient Astronauts  The lost thunderbird photo 2: A bird by any other name, father(s) of cryptozoology, and Propaganda : r/UnresolvedMysteries Interview with a Cryptid Hunter | Canada History and Mystery A GUIDEBOOK TO HIDDEN ANIMALS ShukerNature: THE SPINY-BACKED CHIMPANZEE – A CONGOLESE CHUPACABRA CHIMP!

I AM BIO
Is Space the Next Frontier for Biotech? (Redux)

I AM BIO

Play Episode Listen Later Aug 1, 2023 27:18


The International Space Station has been orbiting in lower earth since 1998 and has been continually inhabited since November 2000. The ISS was originally conceived as a staging base for future missions into deep space. As it turns out, lower earth orbit is an ideal setting for scientific research, from physics and meteorology to astronomy and the life sciences. In this episode we talk with three scientists whose projects are using lower earth orbit to deepen our knowledge of biotechnology and its benefits for mankind.

Sirhud
The Simplest Miracle

Sirhud

Play Episode Listen Later Jul 18, 2023 169:46


Video Form of this Podcast -https://rumble.com/v2oh66c-the-simplest-miracle.html (Slideshow starts 48:21) In this conversation Sirhud is joined by Veda Austin, who is a Water Researcher. She believes that water is fluid intelligence, observing itself through every living organism on the planet and in the universe. Veda sees water as Source rather than a resource, and considers all bodies of water to be sacred. Her passion for water extends out of the freezer and into primary schools where she donates time teaching water science and cleverly intertwines it with art projects for children. Veda's Work - https://www.vedaaustin.com/ Veda's Ig - https://www.instagram.com/vedaaustin_water/ Sirhud's Work - https://sirhud.com/ Sirhud's Ig - https://www.instagram.com/sirhud.kalra/ Chapters -  (0:05:24) - The Fourth Stage Of Water (0:17:53) - Significance of your Intentions / How to receive Water (0:25:56) - Water's Energy Reading Capabilities (0:38:25) - Where the unseen become seen (0:47:52) - Crystallography (refer to video form to see her work) (0:53:34) - Crystallography and Its Creative Applications (1:07:00) - Semantics of Water / Spirit of water (1:19:18) - The Potential of Healing Through Proximity (1:32:40) - To know the subtle it's actually heavy/ Be Water my Friend (1:43:20) - Language and Love (1:55:07) - The Connective Power  (2:02:03) - Connecting to the force of water (2:12:41) - The Power of Natural Elements (2:19:03) - Filtering Water for Health and Wellbeing (2:29:30) - Solutions in Simplicity (2:36:29) - Thank you Life 

I AM BIO
Is Space the Next Frontier for Biotech?

I AM BIO

Play Episode Listen Later Apr 25, 2023 27:18


The International Space Station has been orbiting in lower earth since 1998 and has been continually inhabited since November 2000. The ISS was originally conceived as a staging base for future missions into deep space. As it turns out, lower earth orbit is an ideal setting for scientific research, from physics and meteorology to astronomy and the life sciences. In this episode we talk with three scientists whose projects are using lower earth orbit to deepen our knowledge of biotechnology and its benefits for mankind.

Amalia Kussner - Miniature Artist of the Gilded Age

As with my earlier podcast episodes, this episode will have a more personal slant – telling my listeners about a memorable college professor. This came about since I connected again recently with my alma mater – the University of New Hampshire in Durham, NH. On my first visit to the campus in about 40 years, I was flooded with memories, especially those of professor and superb educator – Dr. Cecil J. Schneer. I was fortunate to take 3 courses from him and also was an assistant for an academic conference he hosted in 1976. He made impressive contributions to both the fields of geology and history and was a welcome colleague to many. In addition, you will also hear great stories about him from a professional colleague, Dr. Wallace Bothner, professor Emeritus at UNH,  and a family perspective  from nephew, Dr. Jonathan Schneer, Professor Emeritus at Georgia Tech.  Episode Section Markers:1) Introduction2) Brief life history (4:41) 3) Interview - Dr. Wallace Bothner (10:26)4) Interview - Dr. Jonathan Schneer (21:54)5) Memorials (30:13) 6) Excerpts from 1976 NH Conference on the History of Geology (31:26)7) Cecil Schneer's Work on William Smith map (35:32) Memorial from Dr. Kenneth Taylor (April 2017).William Smith Map - James Hall - UNH Links to books published by Dr. Jonathan Schneer (on Amazon):The Balfour DeclarationThe Lockhart Plot People Hidden in History information:Website: https://peoplehiddeninhistory.comDirect linkBasic Website with all Episodes/All PlatformsTwitter/Instagram: @phihpodMastodon: @phihpod@historians.social

This is Not a History Lecture
109. Velocipedes and Crystallography

This is Not a History Lecture

Play Episode Listen Later Mar 7, 2023 109:40


Happy International Women's History Month! We're kicking things off with a great episode - Kat gets us rolling with a history of the bicycle and how essential it was to women's liberation. Kaleigh then closes us out with a look at the life and times of Rosalind Franklin, the woman who discovered the structure of DNA.Let's Chat! Twitter: @TINAHLpodcastEmail: thisisnotahistorylecture@gmail.comRemember to rate us wherever you can!

My Family Thinks I'm Crazy
Dan Winter | Golden Phi Ratio, John Dee to The Philadelphia Experiment? Templar Rose and Alchemical Cathedrals

My Family Thinks I'm Crazy

Play Episode Listen Later Jan 23, 2023 115:50


Dan Winter a Multifaceted expert on all things Fractality, Crystallography, Metallurgy, Mythology, Semiotics, Science, Science Fiction and so much more joins me to discuss Fractality and Phi Ratio. Dan is one of the minds behind Gaia, and his work can be found at the following websites, Fractalfield.com, Goldenmean.info, Therapi.net, and FractalU.com. We discussed a wide range of topics in this conversation from the physics of implosion and fractality to the Templars and John Dee who may be connected in practice to The Philadelphia Experiment! Rose forms of energy, dragon lines, ley lines and even Orion Star-Gates. Our Interview on Dan's Youtube https://youtu.be/Sdy7fR-JZDoShare This Episode: https://share.transistor.fm/s/a779330d This Podcast is Sponsored by the Hit Kit! check out the Hit Kit Here  https://hitkit.us/New Booklet by Mystic MarkS.E.E.E.N. #2 N.E.M.M.E.S.S.I.S.S. Buy Nowhttps://ko-fi.com/s/9baa70f625Synchro-Wisdom Dialogue: https://linktr.ee/mysticmarkpodcastMFTIC Merchhttps://mftic-podcast.creator-spring.comSupport the Substack https://myfamilythinksimcrazy.substack.com/Join us on TelegramLeave me a message On Telegram!For Exclusive My Family Thinks I'm Crazy Content: Only 3$ get 50+ Bonus Episodes, Sign up on our Patreon For Exclusive Episodes. Check out the S.E.E.E.N.or on Rokfin@MFTICPodcast on Twitter@myfamilythinksimcrazy on Instagram, Follow, Subscribe, Rate, and Review we appreciate you!https://www.myfamilythinksimcrazy.comhttps://altmediaunited.com/my-family-thinks-im-crazy/Listen to Every AMU Podcast with this link. https://lnns.co/pI5xHeyFdfgGET A NEW PODCASTING APP! https://podcastindex.org/appsHelp fund the show, I cannot do this without your support.CashApp: $MarkSteevesJrVenmo: @MysticMarkPaypal: @mysticmarkPatreon: https://www.patreon.com/MFTIC?fan_landing=trueRokfin: https://www.rokfin.com/myfamilythinksimcrazyKo-fi: https://ko-fi.com/myfamilythinksimcrazyBuy Me A Coffee: https://www.buymeacoffee.com/MFTICWithout you this Podcast would not exist, may good karma bless all who support.MUSICAL CREDITSMusic: Sliced BreadBy Dr. DelightOutroMusic: TimeBy DarksliderMusic: Soul TrapBy Tao ShuReleased under a Creative Commons Attribution International 4.0 License Thanks To Soundstripe and FMA CC4.0 ★ Support this podcast on Patreon ★

THE ONE'S CHANGING THE WORLD -PODCAST
CRYSTAL ENGINEERING & WEAK HYDROGEN BONDS- PROF GAUTAM DESIRAJU

THE ONE'S CHANGING THE WORLD -PODCAST

Play Episode Listen Later Oct 3, 2022 36:51


#chemistry #india #chemistrynotes #podcast #toctw Gautam R. Desiraju is a structural chemist who has been in the Solid State and Structural Chemistry Unit of the Indian Institute of Science, Bangalore, India since 2009. Prior to this, he had been in the University of Hyderabad for 30 years. He has played a major role in the development and growth of the subject of crystal engineering & is noted for gaining acceptance for the theme of weak hydrogen bonding among chemists and crystallographers. His books on crystal engineering (Elsevier, 1989; World Scientific, 2011) and the weak hydrogen bond in structural chemistry and biology (OUP, 1999) are particularly well known. He is one of the most highly cited Indian scientists with more than 430 research papers, 40000 citations and an h-index of 83. He has won international awards such as the Alexander von Humboldt Forschungspreis and the TWAS award in Chemistry. He has guided the Ph.D work of around 40 students. He has edited three multi-author books in solid state and supramolecular chemistry. He is a member of the editorial advisory boards of Angewandte Chemie, Chemical Communications and Journal of the American Chemical Society. He is a former President of the International Union of Crystallography. He is a recipient of an honorary doctorate degree of the Universidad Nacional de Córdoba, Argentina, and of the Rayalaseema University, Kurnool. He was awarded the Acharya P. C. Ray Medal (2015) of the University of Calcutta for innovation in science and technology. He was awarded the ISA medal for the science of the University of Bologna for the year 2018. At present, he is the chairman of the Governing Council of the Bose Institute, Kolkata. He has formerly been the chairman of the Research Councils of the National Chemical Laboratory, Pune, and the Indian Institute of Chemical Technology.

Bharatvaarta
202 - Bharat: India 2.0 With Prof. Gautam R. Desiraju | Sharan Setty | Bharatvaarta

Bharatvaarta

Play Episode Listen Later Oct 3, 2022 61:00


Buy Bharat 2.0 on Amazon: http://tiny.cc/Bharat2Amazon Bharat: India 2.0 is a brilliant vision for the nation by one of India's most prominent scientists. Through a meticulous analysis of the proceedings of the Constituent Assembly, Prof. Desiraju demonstrates the limitations of the Westminster model of governance for a country that has nurtured the longest extant human civilization. Specifically, the Indian Constitution of 1950, with its subsequent amendments, has many fault lines related to federalism, secularism and caste-based reservations that will lead to problems in the future. Going beyond conventional analyses, Desiraju argues for changes that acknowledge the civilizational aspects of a deeply religious country and proposes a unique solution to this problem. Gautam Radhakrishna Desiraju was born on 21 August 1952, in Chennai and is presently an honorary professor at Indian Institute of Science, Bangalore. He is a recipient of several prestigious international awards such as the Alexander von Humboldt Forschungspreis, the TWAS Award in Chemistry and the ISI Medal for Science of the University of Bologna. He was President of the International Union of Crystallography between 2011–2014. As IUCr President, he proposed to the United Nations that 2014 be celebrated as the International Year of Crystallography. He spearheaded this resolution and inaugurated the Year in UNESCO, Paris in January 2014 sharing the podium with Irena Bokova, the then Director General of UNESCO. In this episode, host Sharan Setty and Prof. Desiraju delve into the various aspects of the Indian constitution, the author's idea for a new India, various facets of Indian history, and more.  Join this channel to get access to perks:https://www.youtube.com/channel/UCfBf...

The Dictionary
#C530 (crystallography to CU)

The Dictionary

Play Episode Listen Later May 24, 2022 22:30


I read from crystallography to CU.     The word of the episode is "cry up".     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

MRS Bulletin Materials News Podcast
Episode 5: Small molecule structure uncovered via femtosecond-crystallography & algorithm

MRS Bulletin Materials News Podcast

Play Episode Listen Later Apr 4, 2022 4:27 Transcription Available


In this podcast episode, MRS Bulletin's Laura Leay interviews Nate Hohman from The University of Connecticut about the structure of two chalcogenolates his group uncovered. By combining serial femtosecond crystallography —usually used to characterize large molecules—and a clique algorithm, Hohman's group was able to analyze the structure of small molecules. With serial femtosecond crystallography, large molecules like proteins produce thousands of spots on the detector; in contrast, small molecule crystals only a produce a few spots. The algorithm uses the pattern that the spots make on the detector to determine the orientation of as many crystals in the liquid jet as possible. The data from each crystal can then be merged together to find the structure. 

The Nonlinear Library
LW - Mental Crystallography by Alicorn from Living Luminously

The Nonlinear Library

Play Episode Listen Later Dec 26, 2021 4:09


Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is Cartesian Frames, Part 2: Mental Crystallography, published by Alicorn. Brains organize things into familiar patterns, which are different for different people. This can make communication tricky, so it's useful to conceptualize these patterns and use them to help translation efforts. Crystals are nifty things! The same sort of crystal will reliably organize in the same pattern, and always break the same way under stress. Brains are also nifty things! The same person's brain will typically view everything through a favorite lens (or two), and will need to work hard to translate input that comes in through another channel or in different terms. When a brain acquires new concepts - even really vital ones - the new idea will result in recognizeably-shaped brain-bits. Different brains, therefore, handle concepts differently, and this can make it hard for us to talk to each other. This works on a number of levels, although perhaps the most obvious is the divide between styles of thought on the order of "visual thinker", "verbal thinker", etc. People who differ here have to constantly reinterpret everything they say to one another, moving from non-native mode to native mode and back with every bit of data exchanged. People also store and retrieve memories differently, form first-approximation hypotheses and models differently, prioritize sensory input differently, have different levels of introspective luminosity1, and experience different affect around concepts and propositions. Over time, we accumulate different skills, knowledge, cognitive habits, shortcuts, and mental filing debris. Intuitions differ - appeals to intuition will only convert people who share the premises natively. We have lots in common, but high enough variance that it's impressive how much we do manage to communicate over not only inferential distances, but also fundamentally diverse brain plans. Basically, you can hit two crystals the same way with the same hammer, but they can still break along different cleavage planes. This phenomenon is a little like man-with-a-hammer syndrome, which is why I chose that extension of my crystal metaphor. But a person's dependence on their mental crystallography, unlike their wanton use of their hammer, rarely seems to diminish with time. (In fact, youth probably confers some increased flexibility - it seems that you can probably train children to have different crystalline structures to some degree, but much less so with adults). MWaH is actually partially explained by the brain's crystallographic regularities. A hammer-idea will only be compelling to you if it aligns with the crystals in your head. Having "useful" mental crystallography - which lets you comprehend, synthesize, and apply ideas in their most accurate, valuable form - is a type of epistemic luck about the things you can best understand. If you're intrinsically oriented towards mathematical explanations, for instance, and this lets you promptly apprehend the truth and falsity of strings of numbers that would leave my head swimming, you're epistemically lucky about math (while I'm rather likely to be led astray if someone takes the time to put together a plausible verbal explanation that may not match up to the numbers). Some brain structures can use more notions than others, although I'm skeptical that any human has a pure generalist crystal pattern that can make great use of every sort of concept interchangeably without some native mode to touch base with regularly. When you're trying to communicate facts, opinions, and concepts - most especially concepts - it is a useful investment of effort to try to categorize both your audience's crystallography and your own. With only one of these pieces of information, you can't optimize your message for its recipient, because you need to know what you're trans...

The Nonlinear Library: LessWrong
LW - Mental Crystallography by Alicorn from Living Luminously

The Nonlinear Library: LessWrong

Play Episode Listen Later Dec 26, 2021 4:09


Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is Cartesian Frames, Part 2: Mental Crystallography, published by Alicorn. Brains organize things into familiar patterns, which are different for different people. This can make communication tricky, so it's useful to conceptualize these patterns and use them to help translation efforts. Crystals are nifty things! The same sort of crystal will reliably organize in the same pattern, and always break the same way under stress. Brains are also nifty things! The same person's brain will typically view everything through a favorite lens (or two), and will need to work hard to translate input that comes in through another channel or in different terms. When a brain acquires new concepts - even really vital ones - the new idea will result in recognizeably-shaped brain-bits. Different brains, therefore, handle concepts differently, and this can make it hard for us to talk to each other. This works on a number of levels, although perhaps the most obvious is the divide between styles of thought on the order of "visual thinker", "verbal thinker", etc. People who differ here have to constantly reinterpret everything they say to one another, moving from non-native mode to native mode and back with every bit of data exchanged. People also store and retrieve memories differently, form first-approximation hypotheses and models differently, prioritize sensory input differently, have different levels of introspective luminosity1, and experience different affect around concepts and propositions. Over time, we accumulate different skills, knowledge, cognitive habits, shortcuts, and mental filing debris. Intuitions differ - appeals to intuition will only convert people who share the premises natively. We have lots in common, but high enough variance that it's impressive how much we do manage to communicate over not only inferential distances, but also fundamentally diverse brain plans. Basically, you can hit two crystals the same way with the same hammer, but they can still break along different cleavage planes. This phenomenon is a little like man-with-a-hammer syndrome, which is why I chose that extension of my crystal metaphor. But a person's dependence on their mental crystallography, unlike their wanton use of their hammer, rarely seems to diminish with time. (In fact, youth probably confers some increased flexibility - it seems that you can probably train children to have different crystalline structures to some degree, but much less so with adults). MWaH is actually partially explained by the brain's crystallographic regularities. A hammer-idea will only be compelling to you if it aligns with the crystals in your head. Having "useful" mental crystallography - which lets you comprehend, synthesize, and apply ideas in their most accurate, valuable form - is a type of epistemic luck about the things you can best understand. If you're intrinsically oriented towards mathematical explanations, for instance, and this lets you promptly apprehend the truth and falsity of strings of numbers that would leave my head swimming, you're epistemically lucky about math (while I'm rather likely to be led astray if someone takes the time to put together a plausible verbal explanation that may not match up to the numbers). Some brain structures can use more notions than others, although I'm skeptical that any human has a pure generalist crystal pattern that can make great use of every sort of concept interchangeably without some native mode to touch base with regularly. When you're trying to communicate facts, opinions, and concepts - most especially concepts - it is a useful investment of effort to try to categorize both your audience's crystallography and your own. With only one of these pieces of information, you can't optimize your message for its recipient, because you need to know what you're trans...

The Samuel Andreyev Podcast
Christian Bök and the Aesthetics of Impossibility

The Samuel Andreyev Podcast

Play Episode Listen Later Oct 28, 2021 105:29


Born in Toronto, Christian Bök focuses on the intersection of language and science in his work. His first book of poetry, Crystallography, was nominated for the Gerald Lampert Award. His book Eunoia, which won the Griffin Poetry Prize in 2002, is the best-selling Canadian poetry book of all time. Bök has also created artificial languages for science fiction television. His most recent book is The Xenotext (Book One). He lives in Melbourne, Australia. SUPPORT THIS PODCASTPatreonDonorboxORDER SAMUEL ANDREYEV'S NEWEST RELEASEIridescent NotationLINKSYouTube channelOfficial WebsiteTwitterInstagramEdition Impronta, publisher of Samuel Andreyev's scoresEPISODE CREDITSPodcast artwork photograph © 2019 Philippe StirnweissSupport the show (http://www.patreon.com/samuelandreyev)

Eigenbros
Eigenbros ep 129 - Time Crystals Discussion

Eigenbros

Play Episode Listen Later Aug 20, 2021 80:55


Juan & Terence discuss time crystals as conceived of by Frank Wilcek (physicist/mathematician/nobelaureate). The gents give their thoughts about what it is and why its important. Quantum Computing, many-body physics, and spintronics are all related topics that are discussed during the show.

meine Lesung
mL77 - Yvonne Beetz "Der Bernsteinleuchtturm"

meine Lesung

Play Episode Listen Later Jul 5, 2021 63:47


Die Autorin Yvonne Beetz stellt ihr Buch "Der Bernsteinleuchtturm" vor, welches im Rahmen einer AutorenChallenge (AlltagsPausen) entstanden ist. Zum Buch: Emilia wohnt in Brooklyn und ist Studentin an der NYU. Sie hat einen Nebenjob am "Private Museum of Geoscience, Crystallography and Mineralogy", kurz GCM, aus dem eines Tages ein Teil der "Amber Collection" gestohlen wird. Das NYPD, unter Führung von Detektive Sheppard, steht vor einem Rätsel. Erhältlich bei: https://www.amazon.de Zur Autorin: Yvonne Beetz begann ihr Schriftstellerdasein mit Kurzgeschichten. Hauptsächlich verfasst sie ihre Werke für Kinder und Jugendliche. Sie schreibt vorwiegend in Deutsch, aber auch in Englisch. Im Herbst 2021 erscheint ihr Debüt-Roman "Die Wolkenfabrik" im Wreaders Verlag, einer Fantasy mit Gesellschaftskritik, für jugendliche und erwachsene Leser. Auf dem Leseblog "Die Lesefalle" ist wöchentlich eine neue Kurzgeschichte von ihr zu lesen und seit Januar 2020 ist sie eine Dresdner LiteraTurnerin. https://de-de.facebook.com/pg/yvonnebeetz.autorin https://www.instagram.com/yvonnebeetz_autorin ----- (!!!unbeauftrag und unbezahlte Werbung!!!) Dir gefällt dieser Podcast? Dann empfehle ihn weiter und hinterlass eine Bewertung im Apple-Podcastverzeichnis. Herzlichen Dank. Du kannst diesen Podcast auch kostenlos mit der App deiner Wahl abonnieren. Sobald es eine neue Folge gibt, wird diese zum anhören bereitgestellt. Bist du AutorIn und möchtest dein Buch in meinem Podcast vorstellen? Dann melde dich ganz einfach bei mir. Gerne können wir dann alle Einzelheiten besprechen. meinelesung.de

Den of Rich
Artem Oganov | Артем Оганов

Den of Rich

Play Episode Listen Later Feb 22, 2021 122:52


Artem Oganov is a Russian theoretical crystallographer, mineralogist, chemist, physicist, and materials scientist. Professor at Skolkovo Institute of Science and Technology and NUST-MISIS. He is known mostly for his works on computational materials discovery and crystal structure prediction, studies of matter at extreme conditions (including matter of planetary interiors). Oganov graduated from Moscow State University in 1997 with magna summa cum laude and diploma in Crystallography and Crystal Chemistry. In 2002 he obtained a PhD degree in Crystallography from University College London, and in 2007 got a Habilitation degree from ETH Zurich. In 2008 he became Associate Professor and in 2010 Full Professor at Stony Brook University, and since 2015 he is a Professor at Skoltech (Russia). Oganov has published over 260 peer-reviewed articles (many in top journals, e.g. Nature, Science) and book chapters. He is an author of 5 patents. Prof. Oganov has received many awards, and is a Fellow of the Royal Society of Chemistry and of American Physical Society, and a member of Academia Europea, a pan-European elite academy of sciences. In 2017-2020 he was a member of Russian President's Council for Science and Education, and in 2019 he received the Friendship Award of Chinese Government. To leran more about Computational Materials Discovery project USPEX (Universal Structure Predictor: Evolutionary Xtallography) please visit Oganov laboratory's website uspex-team.org FIND ARTEM ON SOCIAL MEDIA Facebook ================================ SUPPORT & CONNECT: Support on Patreon: https://www.patreon.com/denofrich Twitter: https://twitter.com/denofrich Facebook: https://www.facebook.com/denofrich YouTube: https://www.youtube.com/denofrich Instagram: https://www.instagram.com/den_of_rich/ Hashtag: #denofrich © Copyright 2022 Den of Rich. All rights reserved.

Den of Rich
#062 - Artem Oganov

Den of Rich

Play Episode Listen Later Feb 22, 2021 122:52


Artem Oganov is a Russian theoretical crystallographer, mineralogist, chemist, physicist, and materials scientist. Professor at Skolkovo Institute of Science and Technology and NUST-MISIS. He is known mostly for his works on computational materials discovery and crystal structure prediction, studies of matter at extreme conditions (including matter of planetary interiors). Oganov graduated from Moscow State University in 1997 with magna summa cum laude and diploma in Crystallography and Crystal Chemistry. In 2002 he obtained a PhD degree in Crystallography from University College London, and in 2007 got a Habilitation degree from ETH Zurich. In 2008 he became Associate Professor and in 2010 Full Professor at Stony Brook University, and since 2015 he is a Professor at Skoltech (Russia). Oganov has published over 260 peer-reviewed articles (many in top journals, e.g. Nature, Science) and book chapters. He is an author of 5 patents. Prof. Oganov has received many awards, and is a Fellow of the Royal Society of Chemistry and of American Physical Society, and a member of Academia Europea, a pan-European elite academy of sciences. In 2017-2020 he was a member of Russian President's Council for Science and Education, and in 2019 he received the Friendship Award of Chinese Government.To leran more about Computational Materials Discovery Project USPEX (Universal Structure Predictor: Evolutionary Xtallography) please visit Oganov laboratory's website uspex-team.orgFIND ARTEM ON SOCIAL MEDIAFacebook

Chemistry Cayk Online Podcast
66. Chemistry of Paint: Keep It Together

Chemistry Cayk Online Podcast

Play Episode Listen Later Jan 29, 2021 7:25


Episode 1 of our Chemistry of Paint Cayk Bite: chemistry of paint binder! Want to participate in our giveaway? Submit your masterpieces here: https://forms.gle/gsHov3CnZtKHbhfW6 This week's theme: FLORA art pieces! Submissions will close by 11:59 pm PST on February 10. A friendly reminder that in order to be eligible to win one of two X-ray Crystallography badges, you must participate in all three challenges. Additionally, due to shipping circumstances, badges are available to folks in the US and Canada, BUT folks in other parts of the globe are encouraged to participate so we can hype you up! Prizes are courtesy of our sweet friends at d-orbital Games. Give them a follow! Website: https://www.dorbitalgames.org/ Twitter: https://twitter.com/dorbitalgames Instagram:https://www.instagram.com/dorbitalgames/

The Pearl of Great Price
Jan 11 - The Danish Bishop who was the father of Geology

The Pearl of Great Price

Play Episode Listen Later Jan 18, 2021 5:42


Today the 11th of January we remember the Danish Bishop and pioneer in anatomy and geology Nicholas Steno, who was born today (according to the Gregorian Calendar)

It's a Material World | Materials Science Podcast
10: Crystallography and Capsules: MSE in Pharmaceuticals (feat. Dr. Pratik Upadhyay)

It's a Material World | Materials Science Podcast

Play Episode Listen Later Dec 14, 2020 43:58


Among its many applications, Materials Science and Engineering has a strong influence in how we design and package pharmaceuticals. In today's episode we talk with Dr. Pratik Upadhyay, a Senior Scientist at AstraZeneca about the role of optimizing materials to enhance the performance of pharmaceuticals. Furthermore, we explore the connections between the paradigms of drug design and delivery with other subfields of materials science and engineering.   Before we introduce today's guest, check out our free professional development guide for materials scientists and engineers and join our Discord community to meet other passionate MSEs from around the world!   Dr. Pratik Upadhyay can be reached via: https://www.linkedin.com/in/niperpratikpe/    Our topics in today's episode include: The importance of focusing on user needs in this space (4:08) Similarities between pharmaceutical field and other materials fields (7:20) Considerations of polymorphism in drug design (13:08) Optimizing materials properties to enhance manufacturing (21:41) Nanotechnology in the future of pharmaceuticals (25:54) The role of computations in predicting polymorphism (37:54)  And much more!   For shorter segments, subscribe to our channel on YouTube. For bloopers, audiograms, and interesting materials science articles, follow us on Instagram, LinkedIn, and Twitter. Feel free to DM us @itsamaterialworldpodcast if you have any feedback or recommendations for future episodes or email us directly at itsamaterialworldpodcast@gmail.com. Finally, reach out to Tom Miller and Punith Upadhya on LinkedIn if you'd like to chat about the latest breakthroughs in MSE!   Disclaimer: Any opinions expressed by either guests or hosts in this show are their own, and do not represent the opinions of the companies or organizations for which they are affiliated.

PaperPlayer biorxiv biochemistry
Protonation states in SARS-CoV-2 main protease mapped by neutron crystallography

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Sep 22, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.22.308668v1?rss=1 Authors: Kneller, D. W., Phillips, G., Weiss, K. L., Pant, S., Zhang, Q., O'Neill, H., Coates, L., Kovalevsky, A. Abstract: The main protease (3CL Mpro) from SARS-CoV-2, the etiological agent of COVID-19, is an essential enzyme for viral replication, possessing an unusual catalytic dyad composed of His41 and Cys145. A long-standing question in the field has been what the protonation states of the ionizable residues in the substrate-binding active site cavity are. Here, we present the room-temperature neutron structure of 3CL Mpro from SARS-CoV-2, which allows direct determination of hydrogen atom positions and, hence, protonation states. The catalytic site natively adopts a zwitterionic reactive state where His41 is doubly protonated and positively charged, and Cys145 is in the negatively charged thiolate state. The neutron structure also identified the protonation states of other amino acid residues, mapping electrical charges and intricate hydrogen bonding networks in the SARS-CoV-2 3CL Mpro active site cavity and dimer interface. This structure highlights the ability of neutron protein crystallography for experimentally determining protonation states at near-physiological temperature -- the critical information for structure-assisted and computational drug design. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv biophysics
Vital Insights into Prokaryotic Genome Compaction by Nucleoid-Associated Protein (NAP) and Illustration of DNA Flexure Angles at Single Molecule Resolution

PaperPlayer biorxiv biophysics

Play Episode Listen Later Sep 11, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.11.293639v1?rss=1 Authors: Purkait, D., Bandyopadhyay, D., Mishra, P. P. Abstract: Integration Host Factor (IHF) is a heterodimeric site-specific nucleoid-associated protein (NAP) well known for its DNA bending ability. The binding is mediated through the narrow minor grooves of the consensus sequence, involving van der-Waals interaction and hydrogen bonding. Although the DNA bend state of IHF has been captured by both X-ray Crystallography and Atomic Force Microscopy (AFM), the range of flexibility and degree of heterogeneity in terms of quantitative analysis of the nucleoprotein complex has largely remained unexplored. Here we have monitored and compared the trajectories of the conformational dynamics of a dsDNA upon binding of wild-type (wt) and single-chain (sc) IHF at millisecond resolution through single-molecule FRET (smFRET). Our findings reveal that the nucleoprotein complex exists in a Slacked-Dynamic state throughout the observation window where many of them have switched between multiple Wobbling States in the course of attainment of packaged form. A range of DNA Flexure Angles has been calculated that give us vital insights regarding the nucleoid organization and transcriptional regulation in prokaryotes. This study opens up an opportunity to improve the understanding of the functions of other nucleoid-associated proteins (NAPs) by complementing the previous detailed atomic-level structural analysis, which eventually will allow accessibility towards a better hypothesis. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv biophysics
Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing

PaperPlayer biorxiv biophysics

Play Episode Listen Later Sep 9, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.09.287987v1?rss=1 Authors: Durdagi, S., Dag, C., Dogan, B., Yigin, M., Avsar, T., Buyukdag, C., Erol, I., Ertem, F. B., Calis, S., Yildirim, G., Orhan, M., Guven, O., Aksoydan, B., Destan, E., Sahin, K., Besler, S. O., Oktay, L., Shafiei, A., Tolu, I., Ayan, E., Yuksel, B., Peksen, A. B., Gocenler, O., Yucel, A. D., Can, O., Ozabrahamyan, S., Olkan, A., Erdemoglu, E., Aksit, F., Tanisali, G. H., Yefanov, O. M., Barty, A., Tolstikova, A., Ketawala, G. K., Botha, S., Dao, E. H., Hayes, B., Liang, M., Seaberg, M. H., Hunter, M. S., Batyuk, A., Mariani, V., Su, Z., Poitevin, F., Yoon, C. H., Kupitz, C. J., Sierra, R. G., Sn Abstract: The COVID19 pandemic has resulted in 25+ million reported infections and nearly 850.000 deaths. Research to identify effective therapies for COVID19 includes: i) designing a vaccine as future protection; ii) structure-based drug design; and iii) identifying existing drugs to repurpose them as effective and immediate treatments. To assist in drug repurposing and design, we determined two apo structures of Severe Acute Respiratory Syndrome CoronaVirus-2 main protease at ambient-temperature by Serial Femtosecond X-ray crystallography. We employed detailed molecular simulations of selected known main protease inhibitors with the structures and compared binding modes and energies. The combined structural biology and molecular modeling studies not only reveal the dynamics of small molecules targeting main protease but will also provide invaluable opportunities for drug repurposing and structure-based drug design studies against SARS-CoV-2. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv biophysics
Serial femtosecond and serial synchrotron crystallography yield data of equivalent quality: a systematic comparison

PaperPlayer biorxiv biophysics

Play Episode Listen Later Aug 22, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.21.257170v1?rss=1 Authors: Mehrabi, P., Buecker, R., Bourenkov, G., Ginn, H., von Stetten, D., Mueller-Werkmeister, H. M., Kuo, A., Morizumi, T., Eger, B., Ou, W.-L., Oghbaey, S., Sarracini, A., Besaw, J., Pare-Labrosse, O., Meier, S., Schikora, H., Tellkamp, F., Marx, A., Sherrell, D. A., Axford, D., Owen, R. L., Ernst, O. P., Pai, E. F., Schulz, E. C., Miller, R. J. D. Abstract: For the two proteins myoglobin (MB) and fluoroacetate dehalogenase (FAcD), we present a systematic comparison of crystallographic diffraction data collected by serial femtosecond (SFX) and serial synchrotron crystallography (SSX). To maximize comparability, we used the same batch of crystals, the same sample delivery device, as well as the same data analysis software. Overall figures of merit indicate that the data of both radiation sources are of equivalent quality. For both proteins reasonable data statistics can be obtained with approximately 5000 room temperature diffraction images irrespective of the radiation source. The direct comparability of SSX and SFX data indicates that diffraction quality is rather linked to the properties of the crystals than to the radiation source. Time-resolved experiments can therefore be conducted at the source that best matches the desired time-resolution. Copy rights belong to original authors. Visit the link for more info

Trivial Knowledge
Episode 23: From Bagh Chal to Crystallography

Trivial Knowledge

Play Episode Listen Later Aug 18, 2020 26:17


Join us in this next episode as we learn about Lawrence Kohlberg's Stages of Moral Development, discover a board game called Bagh Chal, learn about the science of crystallography, jump into Hungarian cuisine and finish the episode in a park in Canada.

PaperPlayer biorxiv biochemistry
Recognition of high-risk HPV E6 oncoproteins by 14-3-3 proteins studied by interactomics and crystallography

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Jul 24, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.24.220376v1?rss=1 Authors: Gogl, G., Tugaeva, K. V., Eberling, P., Kostmann, C., Trave, G., Sluchanko, N. N. Abstract: In tumors induced by high-risk mucosal human papillomaviruses (hrm-HPVs), HPV E6 oncoproteins inhibit apoptotic processes and sustain cell proliferation. E6 from all hrm-HPVs harbor a C-terminal short PDZ domain-binding motif (PBM), whose phosphorylation down-regulates PDZ binding but triggers E6 binding to 14-3-3 proteins. Here we classify PBMs of E6 proteins depending on their principle ability to be phosphorylated and subsequently acquire a 14-3-3-binding motif III consensus, (pS/pT)XX-COOH. Systematic competitive fluorescence polarization measurements show that the PBMs from four selected E6 oncoproteins bind all seven human 14-3-3 isoforms with distinct, wide-ranging affinities, obeying remarkable trends assigned to 14-3-3 isoform specificity and small E6 sequence variations. We crystallized the hrm-HPV18 E6 PBM bound to 14-3-3{zeta}, revealing a 14-3-3-motif III complex at 1.9 [A] resolution. Using fluorescence polarization and crystallography, we also demonstrate that fusicoccin, a molecule that reinforces many known 14-3-3 complexes, destabilizes the 14-3-3-E6 interaction, indicating the druggability of that complex. Copy rights belong to original authors. Visit the link for more info

Hersterical Podcast
We're not at Hogwarts Anymore Dorothy: Dorothy Hodgkin and Rosalind Franklin the OG's of Xray Crystallography

Hersterical Podcast

Play Episode Listen Later May 3, 2020 30:23


This week's episode focuses on two pioneering women in the field of xray crystallography! So join us to learn what that is, who they are, and how one of them may or may not be a wizard. Additionally, find out what talent Morgan has that leaves Nikki at a loss for words : ).

This Week in Virology
TWiV 577: Virologie structurale with Félix Rey

This Week in Virology

Play Episode Listen Later Dec 8, 2019 75:15


Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

This Week in Virology
TWiV 577: Virologie structurale with Félix Rey

This Week in Virology

Play Episode Listen Later Dec 8, 2019 75:15


Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Of volcanoes and men. Про вулканы и людей
w/ Liudmila Gorelova on Latin, crystallography and dance

Of volcanoes and men. Про вулканы и людей

Play Episode Listen Later Oct 17, 2019 23:15


s2e2. In conversation with Liudmila Gorelova, assistant professor at the Department of Crystallography, Institute of Earth Sciences, Saint Petersburg State University, Russia. Разговор с к.г.-м.н. Людмилой Гореловой, ассистентом кафедры кристаллографии Института наук о Земле СПбГУ. 00:39 Об учёбе в классической гимназии, с древнегреческим и латынью 02:27 Помогала ли латынь в университете на парах по палеонтологии 03:16 Почему всё-таки кристаллография? 05:15 Занятие наукой с первого курса (боросиликаты при высоких температурах) 07:29 Про эксперименты с высокими давлениями 11:01 Про строящийся синхротрон в Новосибирске 13:52 Очень общим языком — про кристаллографию 14:53 Новый минерал, открытый Людмилой на Камчатке 17:40 Как отобрать образец из горячей вулканической фумаролы 21:30 Про танцы :) ResearchGate: https://www.researchgate.net/profile/Liudmila_Gorelova

Poetry On The Move
POTM Winter Readings 1 Christian Bök

Poetry On The Move

Play Episode Listen Later Jul 19, 2019 17:40


Welcome to these special editions of Poetry on the Move, featuring poetry readings from 2018's festival. Christian Bök is the author not only of Crystallography (1994), a pataphysical encyclopedia nominated for the Gerald Lampert Memorial Award, but also of Eunoia (2001), a bestselling work of experimental literature, which has gone on to win the Griffin Prize for Poetic Excellence. Bök teaches English at Charles Darwin University .

Meet Cute
Crystallography

Meet Cute

Play Episode Listen Later May 28, 2019 31:44


Things are getting a little hairy between art and science.In this sparkling conclusion to Ography Month, Lauren and Lee saturate the conversation with talk of crystallography. Discussion eventually gets around to the topic at hand but takes some unexpected turns towards an usual adaptation of the Taco Bell logo, an enticing European trio, and being cold where it really counts this summer.Turns out there’s a merkin for your armpits, who knew?

Ludology
GameTek Classic 199 - Crystallography

Ludology

Play Episode Listen Later May 12, 2019 5:38


Geoff discusses the art of x-ray diffraction, and how it relates to board games.

Materialism
E5 Solving Structures with X-Rays

Materialism

Play Episode Listen Later May 6, 2019 67:33


Episode Notes In this episode we cover the history and development of crystallography, the study of the structures that make up the materials around us. The history of this field is filled with accidental discoveries, ingenious inventions, and drama between those who study it. One of the most important discoveries to come out of this field is x-ray diffraction. This important characterization technique allowed scientists to delve deeper into crystal structures than ever before. We discuss new advances in x-ray diffraction with Ben Frandsen, an assistant professor of physics at Brigham Young University. Ben utilizes x-ray and neutron diffraction techniques to study super conductors and magnets. We only scratch the surface of the fascinating history of crystallography in this episode. If you want to learn even more, check out Nature's Milestones in Crystallography.If you have questions or feedback please send us emails at materialism.podcast@gmail.com. Make sure to subscribe to the show on iTunes, Spotify, google play or wherever you find your podcasts. If you like the show and want to help us reach more people, consider leaving review - it helps us improve and it exposes new people to the show. Finally, check out our Instagram page @materialism.podcast and connect with us to let us know what new material you’d like to hear about next. We’d like to give a shoutout to AlphaBot for allowing us to use his music within the podcast. Check him out on Spotify. And as always a special thanks to Kolobyte who created the intro and outro for our podcast. He makes a ton of really cool synthwave music which you can check out at kolobyte.bandcamp.com.Find out more at https://materialism.pinecast.co

Curioscity
18 - Methods to See Really Small Things (w/ Neela Yennawar!)

Curioscity

Play Episode Listen Later May 1, 2019 48:10


A picture is worth 1,000 words and scientists’ pictures tend to be crystal structures. What are ways that that scientists can see very small things? How are these techniques different for material science, biology, chemistry, or physics? What is crystallography? Let’s learn to be scientifically conversational. For all references and supplemental information, you can navigate to ascienceshow.com.

This Week in Virology
TWiV 529: Rueckert Road

This Week in Virology

Play Episode Listen Later Jan 8, 2019 75:53


At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. Host: Vincent Racaniello Guest: Roland R. Rueckert Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Video of this episode (YouTube) Roland's first paper (Anesthesiol) Purification of phiX174 (Virology) Studies on viral structure (Virology) Automated gel fractionator (Anal Bioch) Picornaviral gene order (J Virol) Picornavirus protease discovery (J Virol) Poliovirus processing map (J Virol) Nomenclature of picornavirus proteins (J Virol) Black beetle virus (J Virol) Rhinovirus crystallization (PNAS) Mapping mAb binding sites (J Virol) Replication of animal virus in yeast (PNAS) Roland's last paper (J Virol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

30 Second Bytes with Dietitian Cindy

Through the end of October I'll be talking "Frightening Food Facts" so don't forget to subscribe. Thank you for listening.  You read that right. Cockroach milk could be inline to take the Superfood crown. Resources for your reading pleasure below!  --- Sources: Ramaswamy et al - Structure of a heterogeneous, glycosylated, lipid-bound, in vivo-grown protein crystal at atomic resolution from the viviparous cockroach Diploptera punctata - the journal of the International Union of Crystallography, July 2016 http://naturalsociety.com/cockroach-milk-could-be-the-next-superfood-8423/ http://www.foxnews.com/health/2016/09/14/is-cockroach-milk-new-superfood.html

Fuzzy Logic Science Show
2014- The Year of Crystallography

Fuzzy Logic Science Show

Play Episode Listen Later Apr 27, 2014 51:27


This year is the international year of crystallography and to celebrate Fuzzy Logic presenter Broderick has brought crystallography expert Dr Darren Goosens into the studio.  Dr Goosens shares his knowledge of some of todays applications for crystals, discusses what makes a crystal and also talks about some of the interesting history surrounding this science.

Science Signaling Podcast
Science Podcast - 100 years of crystallography, linking malaria and climate, and a news roundup (7 Mar 2014)

Science Signaling Podcast

Play Episode Listen Later Mar 7, 2014 32:41


Celebrating crystallography's centennial; how climate pushes malaria uphill; roundup of daily news with David Grimm.

BBC Inside Science
Horsemeat; NanoSims; Early bacteria; Crystallography

BBC Inside Science

Play Episode Listen Later Dec 12, 2013 27:30


Food crime is now big business that criss crosses national boundaries, according to today's report into the safety and authenticity of our food. Public Analyst, Dr Duncan Campbell tells Dr Adam Rutherford that he and his colleagues are hampered by lack of funding and the lack of a national plan for a sustainable laboratory infrastructure. While report author, Professor Chris Elliott, the director of the Global Institute for Food Security at Queen's University, Belfast describes how he wants the UK's scientific infrastructure to be strengthened to avoid yet another serious food scandal.Show Us Your Instrument: Cosmic Scientist Dr Natalie Starkey from the School of Planetary and Space Sciences at the Open University reveals the NanoSims instrument.Thousands of miles apart the same species of microbes seem to crop up deep beneath the earth's surface in cracks of hard rock. Yet nobody seems to quite know how they spread so widely. Scientists now believe they may have survived completely isolated from the surface for what could be billions of years. Dr Matt Shrenk from Michigan State University explains that the biosphere as we know it is far more extensive than we previously thought.Crystallography... as it sounds is the study of crystals, but it's not quite as simple as that. It underpins many scientific fields and yet it remains a relatively unknown subject area. Scores of Nobel prizes have been won, the first almost 100 years ago and we wouldn't understand the structure of DNA without it. The United Nations has declared 2014 as the International Year of Crystallography and emeritus Professor Mike Glazer from Oxford University says he hopes it will help bring the subject out of the shadows.Producer: Fiona Hill.

MicrobeWorld Video HD
MWV Episode 69 - Richard Cogdell - Bacterial Photosynthesis

MicrobeWorld Video HD

Play Episode Listen Later Apr 16, 2013 9:17


Richard Cogdell is the Director of the Institute for Molecular Cell and Systems Biology at the University of Glasglow, Scotland. Richard was led to a career in studying bacterial photosynthesis by a desire to learn and understand basic photosynthesis, he "wanted to know how natured worked." In 1995, Richard's research group, in collaboration with others, used protein crystallography to determine the three dimensional structure of a light-harvesting complex from the purple bacterium, Rhodospsedomas acidophilia. This breakthrough led to two key elements in the understanding of bacterial photosynthesis. One, once you have established the structure you can understand its function. Two, this view of a light-harvesting complex attracted an interdisciplinary group of scientists from the fields such as chemistry, physics, mathematics and biology. Richard's current challenge is to take the process of photosynthesis (using solar energy to make a fuel) and apply it to the world's energy needs in a sustainable manner. To do this, Richard says "you must break photosynthesis down to it's four most basics steps", absorb solar energy, concentrate it, break it apart and make a fuel. These are the steps that must be duplicated if they are going to be successful at creating sustainable, renewable energy. The first two steps, says Cogdell, are like a solar battery (easy to recreate). The hard part is finding ways to use renewable energy to drive the chemistry. That's the process Richard spends most of his time working on and he uses the concept of an artificial leaf to help explain this complex process to the public. According to Cogdell, if the current rate of investment continues, it will be approximately five to six years before we see a small pilot system that demonstrates the feasibility of the process. Richard emphasizes that if mankind wants to survive, we must find a way to convert solar energy into fuel because when fossil fuels run out so do we.

In Our Time
Crystallography

In Our Time

Play Episode Listen Later Nov 28, 2012 41:56


Melvyn Bragg and his guests discuss the history of crystallography, the study of crystals and their structure. The discovery in the early 20th century that X-rays could be diffracted by a crystal revolutionised our knowledge of materials. This crystal technology has touched most people's lives, thanks to the vital role it plays in diverse scientific disciplines - from physics and chemistry, to molecular biology and mineralogy. To date, 28 Nobel Prizes have been awarded to scientists working with X-ray crystallography, an indication of its crucial importance. The history of crystallography began with the work of Johannes Kepler in the 17th century, but perhaps the most crucial leap in understanding came with the work of the father-and-son team the Braggs in 1912. They built on the work of the German physicist Max von Laue who had proved that X-rays are a form of light waves and that it was possible to scatter these rays using a crystal. The Braggs undertook seminal experiments which transformed our perception of crystals and their atomic arrangements, and led to some of the most significant scientific findings of the last century - such as revealing the structure of DNA. With:Judith Howard Director of the Biophysical Sciences Institute and Professor of Chemistry at the University of DurhamChris Hammond Life Fellow in Material Science at the University of LeedsMike Glazer Emeritus Professor of Physics at the University of Oxford and Visiting Professor of Physics at the University of WarwickProducer: Natalia Fernandez.