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In dieser Der Schmerzcode-Podcast-Folge tauchen Jan-Peer und Marco tief in die komplexe Welt des Schmerzes ein. Sie reflektieren über vergangene Informationen, betonen die Fortsetzung der Reise durch den Schmerz. Heute planen sie, die Signalumschaltung vom ersten zum zweiten Neuron im Rückenmark zu untersuchen und die Bahnen zu betrachten, die letztendlich zum Thalamus führen. Die Gastgeber diskutieren die komplexe Modulation des Schmerzsignals zwischen den Neuronen, heben schmerzhemmende Mechanismen hervor und tauchen tief in die Anatomie des Rückenmarks ein. Die Rolle der Interneurone, die das Schmerzsignal beeinflussen, wird erläutert, ebenso wie die Projektionsbahn im Rückenmark zum Thalamus. Jan-Peer und Marco diskutieren die sensorisch-diskriminativen Komponenten und affektiven Aspekte des Schmerzes sowie die Weiterleitung vegetativer Komponenten wie Schwitzen und Erbrechen über separate Bahnen im Rückenmark. Die komplexe Mechanik der Schmerzweiterleitung im Rückenmark wird betont und die Verarbeitung von Schmerzinformationen im Gehirn beleuchtet. Im weiteren Verlauf des Podcasts wird detailliert über die Verschaltungsebenen vom Rückenmark zum Mittelhirn gesprochen. Die schnelle Reaktion des Wegziehreflexes bei Schmerzreizen wird erklärt und Mechanismen der schmerzhemmenden Effekte sowie segmentale Schmerzhemmung auf spinaler Ebene werden diskutiert. Die Verarbeitung von Signalen im Gehirn zur Schmerzregulierung und -modulation wird erörtert, einschließlich der Bedeutung von Opiatrezeptoren und Neurotransmittern wie Serotonin und Noradrenalin. Therapeutische Ansätze wie Akupunktur, Kryotherapie und Taping, die auf der Stimulierung von Interneuronen basieren, werden beleuchtet. Die Interaktion verschiedener Neurotransmittertypen zur Regulierung von Schmerzsignalen wird beschrieben und potenzielle weitere Untersuchungen zu Mechanismen der Schmerzmodulation in zukünftigen Folgen angedeutet. Der Podcast schließt mit einem Ausblick auf kommende Folgen, in denen das dritte Neuron und die zentrale Schmerzmatrix behandelt werden sollen, sowie einer Betonung der Bedeutung von fundiertem Wissen bei der Schmerzdiagnose und -behandlung.
Originally published in 2019, this episode includes a conversation with Dr. Andrew Van Eps about the three main causes of laminitis as well as their treatment. Dr. Van Eps will also be on the next podcast episode with updated research from the last 4 years on laminitis treatment and prevention. Thank you to our amazing sponsors:Equithrive offers supplements for everything from metabolic health to joint support – get 20% off your first order at equithrive.com with code HUMBLEHOOFCavallo Hoof Boots is offering 20% off a pair of Trek hoof boots at cavallo-inc.com with code HRNAnd special shout out to Grid as New, Mud Control Grids – they are a game changer for any mud issues, big or small! – mudcontrolgrids.com
Originally published in 2019, this episode includes a conversation with Dr. Andrew Van Eps about the three main causes of laminitis as well as their treatment. Dr. Van Eps will also be on the next podcast episode with updated research from the last 4 years on laminitis treatment and prevention. Thank you to our amazing sponsors:Equithrive offers supplements for everything from metabolic health to joint support – get 20% off your first order at equithrive.com with code HUMBLEHOOFCavallo Hoof Boots is offering 20% off a pair of Trek hoof boots at cavallo-inc.com with code HRNAnd special shout out to Grid as New, Mud Control Grids – they are a game changer for any mud issues, big or small! – mudcontrolgrids.com
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.17.537173v1?rss=1 Authors: Gallimore, C. G., Ricci, D., Hamm, J. P. Abstract: Context modulates neocortical processing of sensory data. Unexpected visual stimuli elicit large responses in primary visual cortex (V1): a phenomenon known as deviance detection (DD) at the neural level, or mismatch negativity (MMN) when measured with EEG. It remains unclear how visual DD/MMN signals emerge across cortical layers, in temporal relation to the onset of deviant stimuli, and with respect to brain oscillations. Here we employed a visual oddball sequence (a classic paradigm for studying aberrant DD/MMN in neuropsychiatric populations) and recorded local field potentials in V1 of awake mice with 16-channel multielectrode arrays. Multiunit activity and current source density profiles showed that while basic adaptation to redundant stimuli was present early (50ms) in layer 4 responses, DD emerged later (150-230ms) in supragranular layers (L2/3). This DD signal coincided with increased delta/theta (2-7Hz) and high-gamma (70-80Hz) oscillations in L2/3 and decreased beta oscillations (26-36hz) in L1. These results clarify the neocortical dynamics elicited during an oddball paradigm at a microcircuit level. They are consistent with a predictive coding framework, which posits that predictive suppression is present in cortical feed-back circuits, which synapse in L1, while prediction errors engage cortical feed-forward processing streams, which emanate from L2/3. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Co-hosts Dr. Tania Cubitt and Katy Starr discuss laminitis in horses, including what is laminitis, what is the difference between laminitis and founder, causes of laminitis, how to feed a horse with laminitis, feed and management strategies to prevent laminitis and so much more. We're also joined by two special guest who also happen to be listeners of the Beyond the Barn podcast.____________________________________ Register NOW! For our Horse Nutrition Facebook Live Q & A Event “Getting Pastures and Horses Ready for Spring Grazing” - https://fb.me/e/3mXcs9rDy____________________________________Additional Resources - “Symptoms, Causes and Feed Management for Laminitis” – Blog post“How to Avoid High NSC Intake for Horses in the Spring” – Blog post“Teff Grass Pellets to the Rescue” – Nutritional White Paper“Spring Pasture Turnout – What We Need to Know” – Nutritional White Paper“Cresty Neck – A Precursor to Metabolic Disease in Horses” – Nutritional White Paper____________________________________Love the podcast? Leave a rating and review on Apple – https://podcasts.apple.com/.../beyond-the-barn/id1541221306Leave a rating on Spotify – https://open.spotify.com/show/3dmftQmwLKDQNueUcCJBZaHave a topic idea or feedback to share? We want to connect with you! Email podcast@standlee.comShare our podcast and learn more about our co-hosts at our Beyond the Barn podcast pageSUBSCRIBE to the Beyond the Barn podcast email to be an exclusive insider!Find us on Apple, Spotify or Google Podcasts and SUBSCRIBE, so you never miss an episode.____________________________________Check out the Standlee Barn Bulletin BlogFind more nutritional resources from Dr. Stephen Duren and Dr. Tania Cubitt at https://www.standleeforage.com/nutrition/nutritional-resourcesConnect with Standlee on Facebook, Instagram, YouTube and TikTok____________________________________*Views and opinions expressed by guests are their own and do not necessarily reflect the view of Standlee Premium Products, LLC.*
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.19.102186v1?rss=1 Authors: de Hollander, G., van der Zwaag, W., Qiang, C., Zhang, P., Knapen, T. Abstract: Ultra-high field MRI can functionally image the cerebral cortex of human subjects at the submillimeter scale of cortical columns and laminae. Here, we investigate both in concert, by, for the first time, imaging ocular dominance columns (ODCs) in primary visual cortex (V1) across different cortical depths. We ensured that putative ODC patterns in V1 (a) are stable across runs, sessions, and scanners located in different continents (b) have a width (~1.3 mm) expected from post-mortem and animal work and (c) are absent at the retinotopic location of the blind spot. We then dissociated the effects of bottom-up thalamo-cortical input and attentional feedback processes on activity in V1 across cortical depth. Importantly, the separation of bottom-up information flows into ODCs allowed us to validly compare attentional conditions while keeping the stimulus identical throughout the experiment. We find that, when correcting for draining vein effects and using both model-based and model-free approaches, the effect of monocular stimulation is largest at deep and middle cortical depths. Conversely, spatial attention influences BOLD activity exclusively near the pial surface. Our findings show that simultaneous interrogation of columnar and laminar dimensions of the cortical fold can dissociate thalamocortical inputs from top-down processing, and allow the investigation of their interactions without any stimulus manipulation. Copy rights belong to original authors. Visit the link for more info
In this episode, Dr. Andrew Van Eps delves into new research on laminitis and founder treatment, as well as the importance of prevention. In it, you will hear about the three causes of laminitis, and research into how to approach each cause. Prevention is better than "damage control," and implementing some changes in your horse's diet and lifestyle can make all the difference! If you'd like to reach out to Dr. Van Eps, you can email him at vaneps@vet.upenn.edu, or see his work at New Bolton Center at https://www.vet.upenn.edu/veterinary-hospitals/NBC-hospital . Also featured: Dr. Chris Pollitt, Ann Ramsey, Daisy Bicking, and Candice Piraino.
In this podcast Gigi Kay discusses locally invasive melanoma in the internal laminae of the hoof and Apryle Horbal discusses her paper on head and neck abscessation and thrombophlebitis following cheek tooth extraction. Please find a link to the related papers below: Locally invasive melanoma in the internal laminae of the hoof of a bay mule. Head and neck abscessation and thrombophlebitis following cheek tooth extraction in a pony
Earth's physical resources: extracting coal and oil - for iPod/iPhone
Describing what the Athabasca oil sands look like and the unique conditions that led to their formation.
Earth's physical resources: extracting coal and oil - for iPod/iPhone
Transcript -- Describing what the Athabasca oil sands look like and the unique conditions that led to their formation.
Earth's physical resources: extracting coal and oil - for iPad/Mac/PC
Describing what the Athabasca oil sands look like and the unique conditions that led to their formation.
Earth's physical resources: extracting coal and oil - for iPad/Mac/PC
Transcript -- Describing what the Athabasca oil sands look like and the unique conditions that led to their formation.