Podcasts about Southall

The results of our listeners poll to find the most loved stories of the Matt Smith era Presented by J.R. Southall, with Jon Arnold, Matt Barber, Steve Hatcher and Ian Winterton

In which Steven Spielberg goes back to the early days of his career and produces a new spin on Close Encounters of the Third Kind. Well, we say "new"; he updates it to the themes and concerns of the mid-1990s at least. Presented by J.R. Southall, with Ian Winterton

Who Review Extra takes us right back into The Avengers again, and this time into the middle of Season Four to find Mrs Peel settling in nicely and the format fully up and running... Presented by J.R. Southall, with Jon Arnold and Matt Barber

Christopher Nolan's latest is another updating of the movies he no doubt caught during summer holidays when he was a kid; the fidelity of his vision isn't important, so much as the quality of the outcome Presented by J.R. Southall, with Ian Winterton

Warning: there are big spoilers to significant plot developments in our review of the latest from the MCU, so make sure you've seen Spider-Man: Brand New Day before you listen to this episode Presented by J.R. Southall, with Jon Arnold, Ryan Blake and Simon Brett

It's been possibly the cinema sensation of the summer; we finally took a look at Curry Barker's low budget, big box office, high concept horror film Obsession Presented by J.R. Southall, with Jon Arnold, Matt Barber and Ian Winterton

In this episode, we speak with Andrea Brand, Chair of the Department of Cell Biology at NYU Grossman School of Medicine and Director of the Regenerative Medicine Institute. We discuss her scientific path from yeast gene regulation to Drosophila neurobiology, and how early interests in DNA and microscopy shaped her career. We talk about the development of the GAL4 system with Norbert Perrimon and how it enabled targeted gene expression in specific tissues and cells. Andrea explains why this approach has remained useful across decades, including its applications in Drosophila and beyond, while noting that no experimental system is perfect and results should be cross-checked with other methods. We also discuss targeted DAM-ID and chromatin DAM-ID, methods developed in her lab to study protein-DNA interactions and chromatin marks in vivo without removing cells from their normal tissue environment. Andrea describes how these tools helped her lab analyze neural stem cells in their niche and investigate changes in chromatin during quiescence and reactivation. A major theme of the conversation is neural stem cell quiescence. We cover how her lab found that quiescent stem cells can show unexpectedly open chromatin, express neuronal genes, and adopt neuron-like features, including long projections and interactions with neurons. We also discuss the link to metabolism, including feeding signals, the fat body, blood-brain barrier glia, insulin-like peptides, and TGF-beta signaling. Finally, we talk about Andrea's recent move toward human brain organoids and the goal of connecting model organism work to human biology and patient data. We discuss ongoing work on quiescent cells, TRIB family genes, and cancer–neuron interactions, as well as the need to better distinguish quiescence from senescence in vivo. References Brand, A. H., & Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (Cambridge, England), 118(2), 401–415. https://doi.org/10.1242/dev.118.2.401 Southall, T. D., Gold, K. S., Egger, B., Davidson, C. M., Caygill, E. E., Marshall, O. J., & Brand, A. H. (2013). Cell-type-specific profiling of gene expression and chromatin binding without cell isolation: assaying RNA Pol II occupancy in neural stem cells. Developmental cell, 26(1), 101–112. https://doi.org/10.1016/j.devcel.2013.05.020 Tang, J. L. Y., Hakes, A. E., Krautz, R., Suzuki, T., Contreras, E. G., Fox, P. M., & Brand, A. H. (2022). NanoDam identifies Homeobrain (ARX) and Scarecrow (NKX2.1) as conserved temporal factors in the Drosophila central brain and visual system. Developmental cell, 57(9), 1193–1207.e7. https://doi.org/10.1016/j.devcel.2022.04.008 Cheetham, S. W., & Brand, A. H. (2018). RNA-DamID reveals cell-type-specific binding of roX RNAs at chromatin-entry sites. Nature structural & molecular biology, 25(1), 109–114. https://doi.org/10.1038/s41594-017-0006-4 Cheetham, S. W., Gruhn, W. H., van den Ameele, J., Krautz, R., Southall, T. D., Kobayashi, T., Surani, M. A., & Brand, A. H. (2018). Targeted DamID reveals differential binding of mammalian pluripotency factors. Development (Cambridge, England), 145(20), dev170209. https://doi.org/10.1242/dev.170209 Related Episodes scDamID, EpiDamID and Lamina Associated Domains (Jop Kind) Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

A pair of low budget horror films from YouTubers have created a sensation (and upset the box office spectrum) this summer, so in the first of two reviews we take a look at Kane Parsons' Backrooms (warning: contains spoilers) Presented by J.R. Southall, with Jon Arnold, Matt Barber and Ian Winterton

We talk through some of the names who might be expected to be putting in bids to become the new artistic director on Doctor Who, after BBC Studios confirmed its hat would be in the ring Presented by J.R. Southall, with Jon Arnold and Matt Barber

You don't have to have watched Citizen Vigilante in order to appreciate our review of it, in fact we recommend you don't Presented by J.R. Southall, with Ryan Blake

On the day Andy Burnham becomes Prime Minister, we go back to his Party Pieces interview with The Quietus in 2022, and ask whether we think the man who chose to be represented by these thirteen records is the right man to represent us in the highest office in the country. Or maybe just give our opinions on his opinions. Presented by J.R. Southall, with Simon Brett and Eric Drass Party Pieces: https://thequietus.com/interviews/bakers-dozen/andy-burnham-bakers-dozen-favourite-music/

In the first half (albeit recorded second) of a Too Hot for TV crossover, we take a look at the ill-fated 1980s TV adaptation of John Christopher's The White Mountains trilogy Presented by J.R. Southall, with Ryan Blake and Dylan Rees On tomorrow's episode of Too Hot for TV (recorded first), we'll be looking at the prequel novel and various comic strip adventures: https://linktr.ee/Dylan_Rees

With The Avengers now in the randomiser we take Who Review Extra all the way back to February of 1963, a time before Doctor Who even existed, to check out the Season 2 episode School for Traitors and see how it stands up against the style the series would hit later on Presented by J.R. Southall, with Jon Arnold and Matt Barber

In the aftermath of MayGann, we take a look at Smart Money, the 1986 TV movie that predicts the hacker dramas of the 1990s and which is the first collaboration between TV movie writer Matthew Jacobs and Candyman director Bernard Rose Presented by J.R. Southall, with Jon Arnold and Matt Barber You can watch Smart Money here on YouTube: https://youtu.be/1wVSRDFWc9E

Paul McGann's very first screen appearance was in a Play for Today written by Wally K Daly (author of the ill-fated Doctor Who story The Ultimate Evil), and so we extended MayGann in order to take a look Presented by J.R. Southall, with Jon Arnold and Ryan Blake

England's chances in the World Cup, Nigel's farrago in Clacton, Ann Widdecombe's surprising connection to Doctor Who and more in this emergency unstoppable edition of Private Members Club  Presented by J.R. Southall, with Jon Arnold

The results of our listeners poll to find the most loved stories of the Jon Pertwee era Presented by J.R. Southall, with Jon Arnold, Matt Barber and Steve Hatcher

The second film in the DC Gunniverse seems to have stalled at the box office, and it can't just be down to embittered Snyder fans casting a hex upon it - indeed, our review team of four shrank to half its promised size when two didn't even bother to go see it. We decided to make up for their absence by talking longer Presented by J.R. Southall, with Ryan Blake

Films about filmmakers are always intriguing, and back in 1990 the director of The Graduate collaborated with Carrie Fisher to tell a fictionalised account of her relationship with her mother Presented by J.R. Southall, with Jon Arnold and Simon Brett

Now that we've hit July, we can no longer claim it's MayGann, and so by way of saying goodbye we join Sylvester McCoy for his 1996 video diary in which we find him Bidding Adieu to the role of Doctor Who Presented by J.R. Southall, with Jon Arnold and Steve Hatcher

We talk about RTD's latest, with a little bit about Doctor Who at the start Presented by J.R. Southall, with Jon Arnold and Ian Winterton

Our summer of celebration of the TV movie and the surrounding wilderness years brings us to the last licensed-but-unofficial spin-off mini-movie that was made before Doctor Who returned to our screens in 2005, Dæmos Rising Presented by J.R. Southall, with Matt Barber, Ryan Blake, Steve Hatcher and Dylan Rees

Now that we're actually in May Week, here's a little bit more MayGann in the form of Geoffrey Sax's 2005 hit horror film White Noise Presented by J.R. Southall, with Jon Arnold

It only took three days from Andy Burnham's election in Makerfield, to Sir Keir Starmer resigning in Downing Street; for the second time in a week, there are too many developments in government for us not to talk about them Presented by J.R. Southall, with Matt Barber and Ian Winterton

As May week kicks off in Cambridge, MayGann spreads its wings to include Steven Moffat's first turn behind the Doctor Who TV typewriter, The Curse of Fatal Death in 1999 Presented by J.R. Southall, with Jon Arnold, Matt Barber, Ryan Blake, Simon Brett and Steve Hatcher

The game of Prime Ministerial musical chairs appears to have begun again, and so we've dusted off our politics strand in order to have a conversation about it - once we can get onto the subject Presented by J.R. Southall, with Steve Hatcher

He-Man is once again holding aloft his magic sword and so we thought we would compare the new Masters of the Universe movie with its 1987 counterpart, to see which has the most fabulous secret powers Presented by Dylan Rees, with Ryan Blake and J.R. Southall

We take a look at three TV episodes Matthew Jacobs wrote for television after his work on the 1996 Doctor Who movie, a feature-length adaptation of Lorna Doone, an episode of Wexford and the Screen Two instalment Mothertime Presented by J.R. Southall, with Jon Arnold and Matt Barber

The results of our quest to find our listeners' favourite tenth Doctor stories Presented by J.R. Southall, with Jon Arnold, Matt Barber and Steve Hatcher

Christmas is cancelled, and so we convened to discuss what this might mean for the future of Doctor Who Presented by J.R. Southall, with Jon Arnold, Matt Barber and Ryan Blake

We catch up with Geoffrey Sax's career a decade after he directed the TV movie, to find him undergoing yet more behind-the-scenes interference on another adaptation of a beloved children's franchise Presented by J.R. Southall, with Jon Arnold and Matt Barber

By way of tribute to the recently departed Anthony Head, our review of the early David Tennant story Presented by J. R. Southall, with Jon Arnold, Matt Barber and Ryan Blake

We name the stories we think Matthew Jacobs might have chosen, had he been asked to supervise a season of Paul McGann episodes in the wake of the TV movie Presented by J.R. Southall, with Matt Barber, Simon Brett and Steve Hatcher

MayGann continues - if May Week hasn't happened yet, then we still consider it May - with our review of Paperhouse, Bernard Rose's beguiling but terrifying fantasy that was written by Matthew Jacobs Presented by J.R. Southall, with Jon Arnold and Matt Barber

As the tumbleweeds gather around the forthcoming Doctor Who Christmas Special, and a year passes since the show was last being broadcast on television, we take stock of the situation and the swirling rumours surrounding the lack of production Presented by J.R. Southall, with Jon Arnold and Matt Barber and the ghost of Steve Hatcher

Matthew Jacobs, writer of the TV movie, stops by for a chat about his career, his process and his influences - and of course about Doctor Who Presented by J.R. Southall

It's thirty years since Paul McGann's sole outing in a full-length Doctor Who story hit British television screens, so it's about time we took another look to see what we think of it in 2026 Presented by J.R. Southall, with Jon Arnold, Matt Barber and Ryan Blake

We take a look at a couple of episodes Matthew Jacobs had written for television prior to his work on the Doctor Who TV movie, one for The Jim Henson Hour and the other an instalment of The Young Indiana Jones Chronicles Presented by J.R. Southall, with Jon Arnold and Dylan Rees  

A conversation about the "new" elements that comprised Doctor Who in the 1990s, and whether it was the right time for them Presented by J.R. Southall, with Jon Arnold, Matt Barber and Ryan Blake

Written by Meglos' Flanagan and McCulloch and overseen by Verity Lambert, and with Michael Gough, David Calder and Alan David among the supporting cast - not to mention Nigel Havers and Warren Clarke as the two leads - Sleepers appeared five years before the Doctor Who TV movie with Geoffrey Sax in the director's chair Presented by J.R. Southall, with Jon Arnold

Our appreciation of the work of Paul McGann continues as we try and find him in 2002's rights-grab Interview With a Vampire sequel Queen of the Damned, or indeed anything of merit Presented by J.R. Southall, with Jon Arnold, Ryan Blake and Dylan Rees

The TV movie helped us make it through the wilderness years, but it's far from the only Doctor Who that was produced during the period Presented by J.R. Southall, with Jon Arnold, Matt Barber, Ryan Blake, Steve Hatcher and Dylan Rees

MayGann continues to rifle through the Paul McGann back catalogue, today's selection being the 1986 Alan Bleasdale serial that was largely responsible for launching McGann's screen career Presented by J.R. Southall, with Jon Arnold

MayGann continues with another movie starring Paul McGann, this time as a lesbian vampire hunting priest alongside Hall and Corden, in a film that couldn't possibly be as bad as we remembered it being - could it? Presented by J.R. Southall, with Jon Arnold, Ryan Blake, Luke Molloy and Dylan Rees

MayGann wouldn't be complete without a trip to the Old West, and the Doctor Who set that TV movie writer Matthew Jacobs visited as a child to watch his father as an actor Presented by J.R. Southall, with Jon Arnold and Steve Hatcher

MayGann continues with Paul McGann appearing in a 1997 film called Downtime, as reviewed here by the author of Downtime: The Lost Years of Doctor Who Presented by J.R. Southall, with Dylan Rees Watch Downtime on YouTube: https://youtu.be/hwgXW7UHUpE

With new rumours swirling about where the future of Doctor Who might lie, we take a look at the latest evidence and discuss its potential Presented by J.R. Southall, with Matt Barber and Ryan Blake

MayGann begins in earnest, with our review of Andrew Davies' 2002 adaptation of Sarah Waters' debut novel Tipping the Velvet, as directed by Geoffrey Sax Presented by J.R. Southall, with Jon Arnold

It's Dave Robicheaux agogo in an accidental double bill, after we decided to talk about Heaven's Prisoners (1996) to give Eric Roberts a little coverage before MayGann kicks off in earnest, and ended up recording a whole nother episode on its follow-up film, 2009's In the Electric Mist Presented by J.R. Southall, with Iain Martin and first Matt Barber then Ryan Blake

What happens when modern historians react to historians of the past? In this episode of Boom Goes the History, Garry Adelman brings a wild idea to the table: watching and reacting to old clips of legendary historians. First up—Douglas Southall Freeman. We dive into Freeman's thoughts on respecting the enemy, but the real surprise? Hearing his voice! Join us for a fun, slightly stunned, and occasionally irreverent look at how historians of yesterday sound to historians of today. History, reactions, and a few laughs—boom.