Podcasts about trumenba

In this podcast, Dr. Laura Mohling, a pediatrician with Lakeview Clinic, talks about pathogens that infect children, childhood immunizations, current guidelines regarding vaccine scheduling, and vaccine hesitancy. Enjoy the podcast! Objectives:   Upon completion of this podcast, participants should be able to: Name at least 3 pathogens mentioned in the podcast children/adolescents were/are susceptible to. Distinguish between the two different meningococcal vaccines available. Summarize Human Papilloma Virus (HPV) recommendations for adolescents. CME credit is only offered to Ridgeview Providers & Allied Health Staff for this podcast activity. Complete and submit the online evaluation form, after viewing the activity.  Upon successful completion of the evaluation, you will be e-mailed a certificate of completion within approximately 2 weeks. You may contact the accredited provider with questions regarding this program at  rmccredentialing@ridgeviewmedical.org. To receive continuing education credit for this activity - click the link below, to complete the activity's evaluation. CME Evaluation (**If you are listening to the podcasts through iTunes on your laptop or desktop, it is not possible to link directly with the CME Evaluation for unclear reasons. We are trying to remedy this. You can, however, link to the survey through the Podcasts app on your Apple and other smart devices, as well as through Spotify, Stitcher and other podcast directory apps and on your computer browser at these websites. We apologize for the inconvenience.)  DISCLOSURE ANNOUNCEMENT  The information provided through this and all Ridgeview podcasts as well as any and all accompanying files, images, videos and documents is/are for CME/CE and other institutional learning and communication purposes only and is/are not meant to substitute for the independent medical judgment of a physician, healthcare provider or other healthcare personnel relative to diagnostic and treatment options of a specific patient's medical condition; and are property/rights of Ridgeview Medical Center & Clinics.  Any re-reproduction of any of the materials presented would be infringement of copyright laws.  It is Ridgeview's intent that any potential conflict should be identified openly so that the listeners may form their own judgments about the presentation with the full disclosure of the facts. It is not assumed any potential conflicts will have an adverse impact on these presentations. It remains for the audience to determine whether the speaker's outside interest may reflect a possible bias, either the exposition or the conclusions presented. Ridgeview's CME planning committee members and presenter(s) have disclosed they have no significant financial relationship with a pharmaceutical company and have disclosed that no conflict of interest exists with the presentation/educational event. Thank-you for listening to the podcast. SHOW NOTES:  *See the attachment for the full chapter summaries.  Vaccines - Biggest impact on public health- Vaccine safety continues to improve.- No causation of autism from MMR or other vaccines. (Andrew Wakefield debunking, Thimerosal-free). - ACIP Schedule for Childhood Immunization Meningococcus - Causation - Neisseria meningitidis - Incidence declining - Case fatality approximately 15%, with 10-20% survivor have serious sequelae. - Serogroups       - Serogroup B and C - most frequent cause of disease in U.S.      - Meningitis type B accounts for about 1/3 of cases in adolescents.      - Serogroup A is rare in U.S. - Meningococcal Vaccine      - Meningococcal B vaccines (Trumenba and Bexsero) developed in 2014.      - Vaccine short duration of protection (1-2 years) based on antibody response      - Trumenba (2 doses 6 mos apart) Bexero (2 doses at least 1 mo apart)     - MenACWY vaccine in 2005 primary dose at age 11, booster at age 16. HPV - HPV vaccine is the cancer prevention vaccine!- Statistics - Vaccine - Gardasil 9      - ACIP recommendation of vaccine at age 11 or 12      - dosing schedule of HPV vaccine COVID-19 (SARS-CoV2)- Approved vaccine for age 12 and above. (Pfizer-BioNTech) - RNA vaccines - Antigentic target  - how the vaccine works - Co-administering with other vaccines - ACIP, UpToDate, FDA statements regarding vaccine in adolescents *For links to reference materials please see the full show notes.

Episode 32: VertigoThe sun rises over the San Joaquin Valley, California, today is October 20, 2020.It’s time to talk about vaccines again. The ACIP (Advisory Committee on Immunization Practices) posted new recommendations for meningococcal vaccinations on September 25, 2020. There are two kinds of meningococcal vaccines in the US: 1. Meningococcal conjugate or MenACWY vaccines (Menactra®, Menveo®, and MenQuadfi®)2. Serogroup B meningococcal or MenB vaccines (Bexsero® and Trumenba®). Let’s discuss how they are given.MenACWY: Menactra (MenACWY-D), Menveo (MenACWY-CRW), and MenQuadfi (MenACWY-TT) MenACWY routine: The meningococcal conjugate vaccine should be given to ALL PATIENTS at 11 to 12 years old, with a booster dose at age 16. Remember, it’s a two-dose series, the booster dose at age 16 is important to provide protection during the ages of highest risk of infection. So, that was easy. The hardest part is for patients younger than 10 years old because only patients who are at risk receive routine meningococcal conjugate vaccines before age 11. MenACWY in special groups: This vaccine is given to patients older than 2 months old only if they are at increased risk for meningitis (i.e., persistent complement component deficiencies; persons receiving a complement inhibitor such as eculizumab [Soliris] or ravulizumab [Ultomiris]); persons who have anatomic or functional asplenia; persons with HIV infection; microbiologists routinely exposed to Neisseria meningitidis; persons at increased risk in an outbreak; persons who travel to or live in hyperendemic or epidemic areas; unvaccinated or incompletely vaccinated first-year college students living in residence halls; and military recruits.) I invite you to consult ACIP recommendations regarding vaccination in special groups. MenB: Trumenba (MenB-FHbp), Bexsero (MenB-4C)  MenB shared decision: MenB vaccination is not routinely recommended for all adolescents. It may be given to adolescents and young adults (16 through 23 years old, preferred age is 16-18 years old) on the basis of shared clinical decision. Those who decide to receive MenB vaccine, receive two doses 1-6 months apart depending on the brand name you use. MenB vaccines are not recommended before age 10 in any case. Adults older than 24 and older don’t need MenB unless they are at increased risk.MenB in special groups:Patients with certain medical conditions (persons with persistent complement component deficiencies; receiving a complement inhibitor; with anatomic or functional asplenia; microbiologists exposed to isolates of N. meningitidis; and persons at risk in outbreaks) should receive MenB vaccine. These recommendations will be included in the updated 2021 immunization schedules, and the AAFP will review changes to the schedules once they are available (1).This is Rio Bravo qWeek, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program, from Bakersfield, California. Sponsored by Clinica Sierra Vista, Providing compassionate and affordable care since 1971.____________________________“A man is who he thinks about all day long” –Waldo Emerson.If you think you are not good enough, you may not reach your goals. So, think positive about yourself all day long, and you will become that person you think you are and will reach your goals.Hi, this is Dr Carranza, I’m a PGY3, and today I will interview a special guest.Question Number 1: Who are you? Hello, I’m Jagdeep Sandhu. I’m a 4th year medical student from Ross University, currently doing a sub-internship in family medicine. I’m originally from Seattle, Washington. I have an Indian ancestry, so I enjoy meditating and cooking Indian dishes.Question number 2: What did you learn this week? Lightheadedness vs VertigoThis week we learned about dizziness and its differentials. It is important to differentiate dizziness vs lightheaded because a lot of patients will say they are dizzy when they are truly lightheaded. To be honest dizziness (at least for me) is one of the toughest complaints to get from a patient as it is hard to pinpoint its etiology.Important questions to ask the patient are:Do you feel like you’re going to pass out? Do you experience a sense of darkness in front of your eyes? (points to syncope)Is the room spinning? Are you having nausea or vomiting? Ringing in your ears? (points to vertigo)  Peripheral VertigoPeripheral refers to vertigo originated from the ear structures, whereas central from the brainstem. Differentials of peripheral vertigo include:Benign paroxysmal positional vertigo: Transient episodes of vertigo caused by stimulation of vestibular sense organs, this is most commonly due to calcium debris within the posterior semicircular canal, known as canalithiasis. It affects middle-age and older patients; and twice as many women than men. Classically, patients describe a brief spinning sensation brought on when turning in bed or tilting the head backward to look up. The dizziness is quite brief, usually seconds, rarely minutes.The way to Evaluate/diagnose BPPV is with Dix-Hallpike maneuver (turn the patient’s head 45 degrees to one side, then you help you lie back quickly so their head hangs slightly over the edge of the table. If horizontal or rotation nystagmus is noted, the patient has BPPV) and can be cured with Epley’s maneuver.Vestibular neuritis: This is inflammation of the vestibular nerve, which is usually caused by a viral infection. It’s characterized by rapid onset of severe, persistent vertigo, nausea, vomiting, and gait instability. Hearing is preserved but if there is hearing loss(unilateral), then it is diagnosed as labrynthitis.  You can Evaluate/diagnose with a positive head impulse (or head thrust) test and gait instability but know that the patient is still able to ambulate. (lasts a few days and resolves spontaneously) Herpes zoster oticus: It is also known as Ramsay Hunt syndrome when it causes facial paralysis; it occurs due to latent VZV virus in the geniculate ganglion.  The patient will complain of ear pain and vertigo. On exam, you will find vesicles in the auditory canal and auricle along with ipsilateral facial palsy. You can treat with Acyclovir or Corticosteroids. Meniere disease: Itoccursdue to excess endolymphatic fluid pressure, which causes episodic inner ear dysfunctionresulting in the classic triad of vertigo lasting for minutes to hours, usually associated with unilateral tinnitus and hearing loss. Unfortunately, the hearing loss can sometimes be permanent. It usually affects one ear and although it can occur at any age, most cases start between young adults and middle age adults. Evaluate and diagnose clinical features, get an audiogram for hearing loss. Patients go into remission spontaneously but it can reoccur. Other causes of peripheral vertigo: Labyrinthine concussion (traumatic peripheral vestibular injury)Perilymphatic fistula (complication of head injury, barotrauma, or heavy lifting in which a fistula develops at the otic capsule)Aminoglycoside toxicityVestibular schwannoma (unilateral hearing loss associated with neurofibromatosis type 2) Central VertigoVestibular migraine: The mechanism is unknown, so you have to rely on the patient's history of vertigo associated with migraine headache and classic migraine symptoms such as visual aura, photophobia, or phonophobia.Brainstem ischemia: which is due to embolic, atherosclerotic occlusions of the vertebra-basilar arterial system. A few things fall under this category such as TIA, Wallenberg syndrome (lateral medullary infarction), Labyrinthine infarction (Anterior Inferior cerebellar artery) etc. Evaluate and diagnose with Imaging of the head and treat according to diagnosis.  Question number 3: Why is that knowledge important for you and your patients? It is important for when we are working at both the clinic and at the hospital as recognizing serious vertigo can help us plan for intervention. For example, if a patient presents with vertigo and on exam you find vesicles on their ear and facial paralysis then you can immediately begin therapy with a combination of Valacyclovir and Prednisone but if it is a severe case then the patient might need IV treatment.Also, if the patient has vascular risk factors then it is important to keep ischemia as part of your differential when your patient presents with acute sustained vertigo. Remember that for any stroke time of onset is KEY! CT should be done if MRI is not available but MRI is more sensitive for cerebellar infarctions.Question number 4: How did you get that knowledge? (learning habits)I did an ENT rotation in my 3rd yeard of medical school and learned from Dr Trang. I recommend that rotation to all medical students. I also searched in UpToDate, FP notebook app, AAFP and my attendings. See details below.____________________________Speaking Medical: Otolith by Gina Cha, MDStones are located in many unsuspected places in the body. Such is the case of otoliths. An otolith is a calcium carbonate structure in the saccule or utricle of the inner ear, specifically in the vestibular system of vertebrates. The saccule and utricle, in turn, together make the otolith organs. An otolith can cause great trouble if it’s out of its regular place. When otoliths are dislodged from their usual position within the utricle, and migrate into one of the semicircular canals (most commonly the posterior canal), moving the head causes movement of the heavier otolith debris in the affected canal causing abnormal endolymph fluid displacement and a resultant sensation of vertigo.____________________________Espanish Por Favor: Serenoby Claudia Carranza, MD, and Hector Arreaza, MDHi! This is Dr Carranza with our section “Espanish Por Favor”. The word of the week is SERENO (maybe we can have beach waves crushing in the background). SERENO is a state of mind, a peaceful feeling. To be SERENO means to be calm, peaceful, untroubled, tranquil. Sometimes when people are frustrated or too excited you can say: “Sereno, no te preocupes,” which you can loosely translate as “chill, don’t worry.”Sometimes you might ask someone how they are doing and they can say: “Sereno, sin preocupaciones,” which means “calm, without worries.” Nowadays not many people might actually feel that way but you can always remind them to lay back, relax, and take a deep breath “SERENO!”Another meanings of the word sereno includes “humidity on the atmosphere at night.” In some Latin American countries, sereno can make you sick if you, for example, shower and go outside at night, or you can get worse if you are sick and go outside. The sereno can also be used in folk medicine to “macerate” some herbal teas or remedies giving it a special property to cure illnesses. This may not be used in all countries but at least I know it’s true in Mexico and Venezuela.____________________________For your Sanity: Supermanby Tana Parker, MD Friend 1: Do you want to hear a really good Batman impression?Friend 2: Sure, go on. Friend 1: NOT THE KRYPTONITE!Friend 2: That’s Superman.Friend 1: Thanks, man, I've been practicing. “eBay is so useless. I tried to look up lighters and all they had was 13,749 matches.”“I just saw my wife trip and fall while carrying a laundry basket full of ironed clothes. I watched it all unfold.”I made a playlist for hiking. It has music from Peanuts , the Cranberries, and Eminem. I call it my trail mix._________________________Conclusion: Now we conclude our episode number 32 “Vertigo.” Dr Carranza and Jagdeep had an entertaining conversation about the differential diagnosis of peripheral and central vertigo. Don’t forget to practice the Dix-Hallpike and Epley’s maneuvers for BPPV. Otolith is a tiny stone located in the inner ear that can cause vertigo when it gets stuck in the semicircular canals. The word sereno (pronounced (say-RAY-noe) as an adjective is pretty much the same as the English serene, however, Dr Arreaza explained that sereno as a noun refers to the humidity on the air thought to be the “cause” of many ailments in some Latin cultures. Thanks for listening to Rio Bravo qWeek. If you have any feedback about this podcast, contact us by email RBresidency@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. This podcast was created with educational purposes only. Visit your primary care physician for additional medical advice. This week we thank Hector Arreaza, Arianna Lundquist, Claudia Carranza, Jagdeep Sandhu, Gina Cha, and Tana Parker. Audio edition: Suraj Amrutia. See you next week!     _____________________References:Meningococcal vaccine updates: https://www.aafp.org/news/health-of-the-public/20201007meningococcalvacc.html. Review full article at: https://www.cdc.gov/mmwr/volumes/69/rr/rr6909a1.htm?s_cid=rr6909a1_w Labuguen, Ronald H., M.D., University of Southern California, Los Angeles, California, Initial Evaluation of Vertigo, Am Fam Physician. 2006 Jan 15;73(2):244-251. https://www.aafp.org/afp/2006/0115/p244.html Furman, Joseph M, MD, PhD, and Jason JS Barton, MD, PhD, FRCPC, Evaluation of the patient with vertigo, UptoDate, last updated: Feb 11, 2020. https://www.uptodate.com/contents/causes-of-vertigo?search=vertigo§ionRank=1&usage_type=default&anchor=H5&source=machineLearning&selectedTitle=3~150&display_rank=3#H20 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.24.312546v1?rss=1 Authors: Chen, M., Harrison, O., Bratcher, H., Bo, Z., Jolley, K. A., Rodrigues, C. M., Bray, J., Guo, Q., Zhang, X., Chen, M., Maiden, M. C. Abstract: The expansion of quinolone-resistant Neisseria meningitidis clone ChinaCC4821-R1-C/B from ST-4821 clonal complex (cc4821) caused a serogroup shift from serogroup A to C in invasive meningococcal disease (IMD) in China. To establish the relationship among globally distributed cc4821 meningococci, we analysed whole genome sequence data from 173 cc4821 meningococci isolated in four continents from 1972-2019. These meningococci clustered into four sub-lineages (1-4), with sub-lineage 1 primarily comprising serogroup C IMD isolates (82%, 41/50). Most isolates from outside China formed a distinct sub-lineage (81.6%, 40/49, the Europe-USA cluster), with the typical strain designation B:P1.17-6,23:F3-36:ST-3200(cc4821) and harbouring mutations in penicillin-binding protein 2. These data show that the quinolone-resistant clone ChinaCC4821-R1-C/B has expanded to other countries. The increasing global distribution of B:cc4821 meningococci raises concern that cc4821 has the potential to cause a global pandemic and, this would be challenging to control though there is indirect evidence that Trumenba vaccine might afford some protection. Copy rights belong to original authors. Visit the link for more info

Topic: “World Meningitis Day: Have Your Children Been Vaccinated for Meningitis B?” Guests: Patti Wukovits and Alicia Stillman For more information: www.MeningitisBActionProject.org We’ve heard a lot about the measles outbreak recently. This is a travesty on so many levels because measles is a highly contagious but vaccine preventable illnesses that was declared eliminated in the United States in 2000. Today, in support of World Meningitis Day, we’re going to talk about another vaccine preventable illness starting with M: meningitis. Our guests are both meningitis B advocates for the worst possible reason: they each lost a teenaged daughter to the disease, before a meningitis B vaccine was available in the US. While the meningitis conjugated vaccines have been available for 4 other strains of meningitis since 2005 (Menactra ®  and Menveo ® ), the first meningitis vaccine was available since 1978. The meningitis B vaccine, however, only became available in the US in late 2014 (Bexsero ®  and Trumenba ® ).   Patti Wukovits is a Registered Nurse and meningitis advocate who lost her 17-year-old daughter Kimberly to Meningitis B in 2012. She has since started the Kimberly Coffey Foundation to improve awareness of meningococcal disease and the vaccines available to help prevent it. Patti lives in Massapequa Park, NY, with her husband John. In addition to Kimberly, she has three other adult children.    Alicia Stillman is a meningitis advocate who lost her 19-year-old daughter Emily to Meningitis B in 2013. She has since started the Emily Stillman Foundation to improve awareness of meningococcal disease, the vaccines available to help prevent it, and to encourage organ and tissue donation. Alicia lives with her husband in West Bloomfield, Michigan, where she is the CFO of a multi-state law firm. In addition to Emily, she has two other adult children. Patti & Alicia—and their foundations, the Kimberly Coffey Foundation & the Emily Stillman Foundation—have partnered together to launch the Meningitis B Action Project.

In the kickoff series of the Get Science Podcast, we’re focusing on scientific careers of people working in biopharma, and their different paths and opportunities taken as they hunt for potential cures to human disease.Vaccine research and development just like drug development is risky and challenging work in the pharmaceutical industry. But Kathrin Jansen, Senior Vice President and Head of Vaccine Research and Development at Pfizer, has risen to the upper echelons of the industry based on her flexibility, ability to trust her gut and her determination.Born in Communist East Germany, Jansen’s parents fled to the West where she grew up and eventually earned a PhD in biology at Philipps University in Marburg. She later came to the U.S. to do post-doctoral research at Cornell University. While she initially intended to work in small-molecule drug development, she pivoted to vaccines early on and since then has been involved in the development of three successfully licensed vaccines (Gardasil, Prevnar-13 and Trumenba).Learn more about Jansen’s career journey here.

PharmaPills - Pillole dal farmaceutico: Novità, Curiosità e Lavoro dal mondo del farmaceutico. A cura di Stefano LagravineseIn questa puntata parliamo di:Aziende: EMA, Boehringer Ingelheim, Farmindustria, AIFA, Aridis Pharmaceuticals, Pfizer, Merk, Loxo Oncology, Intercept Pharma, GSK, MSD, Novartis, Worldwide Clinical Trials. Persone: Riccardo Palmisano (Assobiotec), Massimo Scaccabarozzi (Farmindustria), Monica Iurlaro (Boehringer Ingelheim), Beatrice Lorenzin (Ministro della Salute), Stefano Vella (AIFA).Nuove terapie: pseudouridimicina, AR-301, Trumenba, pembrolizumab, larotrectinib, acido obeticolico, idarucizumab, terapia genica con cellule staminali, vaccino anti-HPV, fingolimod.Patologie: polmonite, cancro, cirrosi biliare primitiva, terapia anticoagulante, Ada-Scid, sclerosi multipla.Ogni mercoledì alle h 12.00 su Spreaker.com e iTunes.Seguici su: www.telegram.me/pharmapillswww.facebook.com/pharmapills/Hai un dispositivo Apple? Seguici e abbonati al podcast tramite la app iPod http://nelfarmaceutico.link/pharma-apple

PharmaPills - Pillole dal farmaceutico: Novità, Curiosità e Lavoro dal mondo del farmaceutico. A cura di Stefano LagravineseIn questa puntata parliamo di:Aziende: EMA, Boehringer Ingelheim, Farmindustria, AIFA, Aridis Pharmaceuticals, Pfizer, Merk, Loxo Oncology, Intercept Pharma, GSK, MSD, Novartis, Worldwide Clinical Trials. Persone: Riccardo Palmisano (Assobiotec), Massimo Scaccabarozzi (Farmindustria), Monica Iurlaro (Boehringer Ingelheim), Beatrice Lorenzin (Ministro della Salute), Stefano Vella (AIFA).Nuove terapie: pseudouridimicina, AR-301, Trumenba, pembrolizumab, larotrectinib, acido obeticolico, idarucizumab, terapia genica con cellule staminali, vaccino anti-HPV, fingolimod.Patologie: polmonite, cancro, cirrosi biliare primitiva, terapia anticoagulante, Ada-Scid, sclerosi multipla.Ogni mercoledì alle h 12.00 su Spreaker.com e iTunes.Seguici su: www.telegram.me/pharmapillswww.facebook.com/pharmapills/Hai un dispositivo Apple? Seguici e abbonati al podcast tramite la app iPod http://nelfarmaceutico.link/pharma-apple

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