Retina Synthesis

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Retina Synthesis is a data-focused resource exploring therapies in development for retinal diseases.

Retina Synthesis


    • Jul 12, 2024 LATEST EPISODE
    • every other week NEW EPISODES
    • 16m AVG DURATION
    • 148 EPISODES


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    Latest episodes from Retina Synthesis

    Eyes with both Geographic Atrophy and Neovascular AMD: An IRIS Study

    Play Episode Listen Later Jul 12, 2024 12:07


    We discuss management of eyes with both geographic atrophy and neovascular AMD with Dr. Ted Leng of the Byers Eye Institute, Stanford University School of Medicine

    The Davio 2 Trial for Neovascular AMD

    Play Episode Listen Later May 31, 2024 13:47


    We review the 6 month results of the Davio 2 trial of  the Durayvu TKI delivery system for maintenance therapy of neovascular AMD with Dr. Carl Regillo of Wills Eye Hospital.

    The GALE Extension Study

    Play Episode Listen Later May 17, 2024 15:06


    We discuss the latest promising results from the GALE extension study of pegcetacoplan with Dr. Ashkan Abbey of Texas Retina Associates

    AXPAXLI for Diabetic Retinopathy

    Play Episode Listen Later May 9, 2024 4:44


    We discuss the promising phase I results of the Helios trial studying AXPAXLI  TKI inhibitor implant for diabetic retinopathy with Dr. Dilsher Dhoot of California Retina Consultants.

    NSAIDS in the treatment of Central Serous Chorioretinopathy

    Play Episode Listen Later Apr 18, 2024 14:22


    We discuss the use of non steroidal inflammatory agents in the management of central serous chorioretinopathy  with Dr. Michael Singer of San Antonio, Texas

    EY-103 a novel Wnt Pathway Agonist for Treatment of DME and neovascular AMD

    Play Episode Listen Later Apr 4, 2024 21:41


    We discuss remarkable preliminary results from the the use of intravitreal EYE-103, a novel Wnt pathway agonist in the treatment of DME and neovascular AMD with Dr. Charles Wykoff of Houston Texas.

    Intravitreal Gene Therapy for neovascular AMD with 4D-150

    Play Episode Listen Later Mar 28, 2024 13:44


    We discuss the first interim results of a novel intravitreal gene therapy agent, 4D-150, with Dr. Arshad Khanani of Sierra Eye Associates and the University of Nevada Reno School of Medicine.

    KSI 501 Bispecific Anti-VEGF Biopolymer Treatment of DME

    Play Episode Listen Later Mar 21, 2024 7:38


    We discuss the use of a novel bispecific anti-VEGF Anti IL-6 Antibody Biopolymar Conjugate for the treatment of DME with Dr. Mark R. Barakat of Phoenix, AZ.

    Retinal Vasculitis Following Pegcetcoplan Therapy of Geographic Atrophy

    Play Episode Listen Later Mar 14, 2024 15:25


    We discuss the occurrence of retinal vasculitis following pegcetcoplan therapy of geographic atrophy with Dr. Andrew Witkin of the New England Eye Center, Tufts University School of Medicine

    High Dose Aflibercept in Severe Diabetic Macular Edema

    Play Episode Listen Later Mar 7, 2024 12:22


    We discuss the treatment results of high dose aflibercept in the eyes in the most severe quartile of diabetic macular edema with Dr. Roger Goldberg of Walnut Creek, California.

    IL-6 Inhibition in the Treatment of Uveitis Macular Edema

    Play Episode Listen Later Feb 29, 2024 9:05


    We discuss the use of an IL-6 inhibitor in the treatment of uveitis macular edema with Dr. Sumit Sharma of the Cole Eye Institute, Cleveland Clinic.

    The High Dose Aflibercept DME Trial

    Play Episode Listen Later Feb 22, 2024 18:43


    We discuss the baseline characteristics of eyes in the HD Aflibercept Phase III clinical trial and examine their ability for extended dosing with Dr. Eric Schneider of Tennessee Retina, Nashville, TN.

    The Annexon Geographic Atrophy Trial

    Play Episode Listen Later Feb 15, 2024 11:53


    We discuss the unique results of the Annexon geographic atrophy Phase I clinical trial with Dr. Roger Goldberg of Bay Area Retina Associates, Walnut Creek, California

    Diagnostics for Retinoblastoma

    Play Episode Listen Later Feb 8, 2024 19:04


    We review the latest diagnostic and therapeutic approaches for retinoblastoma with Dr. Jesse Berry, Associate Professor of Ophthalmology, Children's Hospital Los Angeles.

    A Feasbility Evaluating the Use of Home OCT for a Clinical Trial of Faricimab Treatment of nAMD

    Play Episode Listen Later Feb 1, 2024 13:52


    We discuss the feasibility of using home OCT vs. a treat and extend approach in a clinical trial of faricimab in neovascular AMD with Dr. Kevin Blinder of the Retina Institute in Saint Louis, Mo and Profesor of Ophthalmology at Washington University School of Medicine.

    Visual Outcomes in the Davio Trial Looking at TKI EY-1901

    Play Episode Listen Later Jan 25, 2024 6:53


    We discuss the characteristics of eyes with the best visual outcomes in the Davio trial of TKI EY-1901 with Dr. Philip Storey of the Austin Retina Associates, Austin, Texas.

    A Post-Hoc Comparison of Syfovre and Izervay in Treatment of Geographic Atrophy

    Play Episode Listen Later Jan 18, 2024 15:21


    We discuss a post-hoc study comparing the efficacy of Syfovre (pegcetacoplan) and Izervay (avacincaptad pegol) with Paul Hahn, MD, PhD, of NJ Retina.

    4 Year Results from DRCR Network Protocol W

    Play Episode Listen Later Jan 11, 2024 16:24


    We discuss a comparative trial of preventive therapy for non-proliferative retinopathy vs. ad hoc treatment of disease complications with Dr. Hani Salehi-Had of Retina Associates of Southern California, Huntington Beach, California.

    Gene Therapy for X-Linked Retinitis Pigmentosa

    Play Episode Listen Later Jan 4, 2024 18:56


    We discuss the latest information on phase 2 trials of gene therapy for x-linked retinitis pigmentosa with Dr. Nadia Waheed, Chief Medical Officer of Beacon Therapeutics and Associate Professor of Ophthalmology at the New England Eye Center, Tufts University School of Medicine.

    Optogenetic Therapy of Inherited Retinal Degenerations

    Play Episode Listen Later Dec 21, 2023 9:58


    We discuss the use of optogenetics for the treatment of inherited retinal degenerations with Dr. Jose Sahel, Chairman and Distinguished Professor of Ophthalmology at the University of Pittsburgh School of Medicine.

    A Real World Analysis of Aflibercept Therapy of Diabetic Macular Edema

    Play Episode Listen Later Dec 14, 2023 12:50


    We discuss the importance of intensive therapy of DME, when using aflibercept for DME, as suggested by a review of real world cases from the Vestrum  data base, with Dr. Ferhina Ali, Assistant Professor of Ophthalmology, New York Medical College

    Topical Therapy of Diabetic Macular Edema

    Play Episode Listen Later Dec 7, 2023 9:33


    We discuss the use of a topical agent for the treatment of diabetic macular edema with Dr. Arshad Khanani, Director of Research, Sierra Eye Associates, Associate Clinical Professor of Ophthalmology, University Nevada School of Medicine, Reno.

    Mitochrondial Therapy of Intermediate AMD

    Play Episode Listen Later Nov 30, 2023 15:56


    We review novel approaches for the treatment of intermediate AMD, with Dr. Barry Kuppermann, Director Gavin Herbert Eye Institute, Chairman Department of Ophthalmology, University of California Irvine, Steinert Endowed Chair.

    Safety Considerations in Retinal Gene Therapy

    Play Episode Listen Later Nov 16, 2023 24:32


     In our latest update, we discuss safety issues associated with retinal gene therapy with Professor Glenn Yiu of the University of California School of Medicine.

    An Oral Agent for Treatment of Diabetic Retinopathy

    Play Episode Listen Later Nov 9, 2023 12:39


    We discuss the use of a novel oral agent for the treatment of diabetic retinopathy with David R. Lally, MD, Director of Research, New England Retina Consultants, Springfield, MA

    Intravitreal Gene Therapy with 4D-150

    Play Episode Listen Later Oct 26, 2023 11:29


    We discuss intravitreal gene therapy with a new agent, 4D-150 with Veeral Sheth, MD, MBA  Assistant Clinical Professor of Ophthalmology University of Illinois at Chicago.

    Optogenetics in the Treatment of Retinal Degenerations

    Play Episode Listen Later Oct 19, 2023 14:36


    We discuss the use of optogenetics in the treatment of retinal degenerations with Dr. Michael Singer, Adjunct Professor of Ophthalmology, University of Texas Health Science Center, San Antonio.

    Update on the Iluvien System for Treatment of Diabetic Macular Edema

    Play Episode Listen Later Oct 12, 2023 12:25


    We discuss retinal drying in diabetic macular edema using the Iluvien implant with Dr. Michael Singer, Adjunct Professor, University of Texas Health Science Center, San Antonio.

    The Ophthea Clinical Trial for Neovascular AMD

    Play Episode Listen Later Oct 5, 2023 13:44


    We discuss the use of blockade of VEGF C and D in the treatment of neovascular AMD with Dr. Dante Pieramici, California Retina Research Foundation, California Retina Consultants.

    Senolytic Therapy for Diabetic Macular Edema

    Play Episode Listen Later Sep 28, 2023 9:39


    We discuss the use of a novel treatment approach, senolytic therapy, for the treatment of diabetic macular edema with Dr. David Boyer, Adjunct Professor, USC Roski Eye Institute.

    The Port Delivery System for Treating Diabetic Retinopathy

    Play Episode Listen Later Sep 21, 2023 16:36


    We discuss the use of the PDS in the treatment of diabetic retinopathy and diabetic macular edema with Professor Carl Regillo of the Wills Eye Hospital.

    A Profile of Eugene de Juan, MD

    Play Episode Listen Later Sep 14, 2023 20:23


    Dr. Eugene de Juan, winner of this year's ASRS Pyron Award, joins us to discuss his career highlights. Dr. de Juan is CEO of Forsight Labs and Professor of Ophthalmology, University of California, San Francisco.

    Subretinal Gene Therapy for Neovascular AMD

    Play Episode Listen Later Sep 7, 2023 12:52


    In our latest update, We discuss the use of surgical sub retinal gene therapy for neovascular AMD with RGX-314. Our guest Dr. Courtney Crawford, Ft. Worth, Texas.

    An Implantation Telescope for Macular Disease

    Play Episode Listen Later Aug 31, 2023 8:37


    We discuss the use of an improved implantable telescope as a low vision aid in patients with macular disease with Dr. David Almeida, Erie Retina Research.

    Prevention of Vision Loss in the Gather Trial of IZERVAY

    Play Episode Listen Later Aug 24, 2023 11:58


    We discuss the prevention of vision loss in the Gather 2 trial of IZERVAY with Dr. Carl Danzig of the Rand Eye Institute, Pompano Beach, Florida

    GALE Long Term Extension Study for GA

    Play Episode Listen Later Aug 14, 2023 17:48


    We discuss a 30-Month Outcome with Pegcetacoplan for the Treatment of Geographic Atrophy with Nathan Steinle MD, California Retina Consultants, Santa Barbara, California.

    Pegcetacoplan (SYFOVRE) Clinical Update

    Play Episode Listen Later Aug 11, 2023 18:27


    We discuss the latest information on Safety & Efficacy in Clinic and Clinical Trials with Cedric Francois, MD, PhD.

    Faricimab in Neovascular AMD

    Play Episode Listen Later Aug 3, 2023 16:48


    We discuss the latest information on the use of faricimab in neovascular AMD with Dr. Yasha Modi, Associate Professor of Ophthalmology, NYU Langone Medical Center.

    High Dose Aflibercept for Neovascular AMD

    Play Episode Listen Later Jul 27, 2023 15:47


    We discuss the use of high dose aflibercept for the treatment of neovascular AMD with Dr. Andrew Moshfeghi, Associate Professor, Roski Eye Institute of USC.

    Pegcetacoplan for Geographic Atrophy Update

    Play Episode Listen Later Jul 20, 2023 12:16


    We discuss the latest information on the use of pegcetacoplan for geographic atrophy in AMD with Dr. Dilsher Dhoot, California Retinal Consultants.

    Ocular Therapeutix: A TKI and Hydrogel Implant

    Play Episode Listen Later Jul 13, 2023 22:52


    We discuss the use of a novel drug (tyrosine kinase inhibitor) and novel delivery system (hydrogel) for the treatment of neovascular AMD with Dr. Peter Kaiser of the Cleveland Clinic.

    Biosimilar Drugs for Retinal Diseases

    Play Episode Listen Later Jul 6, 2023 23:45


    We discuss the use of biosimilar drugs for retinal diseases with Dr. Arghavan Almony, author of definitive monograph of these agents.

    Faricimab vs Aflibercept in Diabetic Macular Edema

    Play Episode Listen Later Jun 29, 2023 16:08


    In our latest update, we discuss the relative drying effects of faricimab and aflibercept in the treatment of diabetic macular edema with Dr. Roger Goldberg.

    Artificial Intelligence in the Management of Geographic Atrophy

    Play Episode Listen Later Jun 22, 2023 15:34


    In our latest update, we discuss the use of artificial intelligence in the management of geographic atrophy with Professor Pearse Keane, Moorfields Eye Hospital, London.

    Molecular Diagnostics in the Diagnosis and Treatment of Uveal Melanoma

    Play Episode Listen Later Jun 15, 2023 18:13


    In our latest update, we discuss the use of molecular techniques in the management of uveal melanoma with Dr. William Harbour, Professor and Chair, Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas.

    Faricimab in the Treatment of Retinal Venous Occlusion

    Play Episode Listen Later Jun 8, 2023 7:38


    We discuss the results of clinical trials studying  the use of faricimab in the treatment of retinal venous occlusion with Dr. Ramin Tadayoni, Professor of Ophthalmology University of Paris.

    The Use of High Dose Aflibercept in Diabetic Macular Edema

    Play Episode Listen Later Jun 1, 2023 11:13


    We review the one year results of a clinical trial using high dose aflibercept (8mg) for the treatment of diabetic macular edema with Dr. David Boyer, Adjunct Clinical Professor of Ophthalmology, USC Roski Eye Institute

    Widefield OCT Angiography

    Play Episode Listen Later May 25, 2023 17:07


    We the discuss the use of wide field OCT angiography in the management of diabetic retinopathy, retinal vein occlusion, and pediatric retinal disease with Dr. Amir Kashani, Associate Professor of Ophthalmology, Wilmer Eye Institute, Johns Hopkins School of Medicine

    Aflibercept Therapy of Retinopathy of Prematurity

    Play Episode Listen Later May 18, 2023 12:05


    We review the use of anti-VEGF therapy for retinopathy of prematurity and in particular, the results of a clinical trial employing aflibercept with Dr. Darius Moshfeghi, Professor of Ophthalmology, Director of the Retina Service, Byers Eye Institute, Stanford University School of Medicine.

    Home OCT in the Management of Neovascular AMD: Latest Development

    Play Episode Listen Later May 11, 2023 14:56


    We discuss the use of home OCT and artificial intelligence in the management of anti-VEGF therapy of neovascular AMD with Dr. Anat Loewenstein, Director, Department of Ophthalmology, Tel Aviv Medical Center, Israel.

    Suprachoroidal Corticosteroids for the Treatment of Macular Edema

    Play Episode Listen Later May 4, 2023 10:55


    We discuss the use of suprachoroidal triamcinolone for the treatment of macular edema with Dr. Steven Yeh, Truhlsen Chair of Ophthalmology, University of Nebraska School of Medicine.

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