Podcasts about tki

Welcome to the Oncology Brothers podcast! In this episode, we dived into the complexities of chronic myeloid leukemia (CML) through two challenging case studies. Joined by CML experts Dr. Fadi Haddad from MD Anderson Cancer Center and Dr. Gaby Hobbs from Massachusetts General Hospital,  Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Apple Podcast: https://podcasts.apple.com/us/podcast/oncology-brothers-practice-changing-cancer-discussions/id1653340966 Follow us on social media: X/Twitter: https://twitter.com/oncbrothers ⁠Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/ we talked about: The initial workup for diagnosing CML, including the importance of CBC, bone marrow biopsy, and BCR-ABL testing. How to select the most optimal frontline treatment option amongst many available, considering factors like age, comorbidities, and the goal of treatment-free remission (TFR). The role of first-generation TKI, but also how newer TKIs assist in achieving deeper molecular remissions. Strategies for managing treatment breaks and monitoring patients in remission. The role of ponatinib as a pan-BCR:ABL1 inhibitor effective against all known resistance mutations, including T315I, and the optimized response-based dosing strategy to balance efficacy with safety. Tune in for valuable insights on treatment strategies, patient management, and the latest advancements in CML care. Don't forget to like, subscribe, and share your challenging case scenarios for future discussions! #ChronicMyeloidLeukemia, #CML, #TreatmentFreeRemission, #OncologyBrothers

An entire underground alchemy lab complete with alchemical golem and female lab Attendants!www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

The Party finds an Achemy Lab, Gaurded of course!www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

With the lich defeated now only a Giants Evil Alter remains, What to do?www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

TyhyTeko-podcastin kahdeksannessa jaksossa puhutaan EU:n tekoälyasetuksesta eli AI Actista pk-yrityksen näkökulmasta. Savonia-ammattikorkeakoulun TKI-asiantuntijat Mia Hakulinen ja Sini Sarén keskustelevat aiheesta Savonian projektiasiantuntija ja AI actin kanssa pitkään työskennelleen Miia Heiskasen sekä Tekoälyköt Oy:n yrittäjän Oskari Uotisen kanssa. Jaksossa kuullaan mm. mitkä 3 asiaa pk-yrityksissä pitää laittaa kuntoon nyt, jos tekoälyä käytetään työssä sekä millaiset ovat AI-pelisäännöt on hyvä luoda yritykseen. Jakson puhujat: Miia Heiskanen, projektiasiantuntija, Savonia-ammattikorkeakoulu Oy Oskari Uotinen, Yrittäjä, Tekoälyköt Oy Mia Hakulinen, TKI-asiantuntija, Savonia-ammattikorkeakoulu Oy Sini Sarén, TKI-asiantuntija, Savonia-ammattikorkeakoulu Oy Jakson tekijät: Editointi ja tekstivastine: Studio Linjat / KL-Kustannus Oy Käsikirjoitus ja muu tuotanto: Sini Sarén ja Mia Hakulinen, Savonia-ammattikorkeakoulu Oy, TyhyTeko-hanke TyhyTeko-intro, -jingle sekä -outro: Riitta Koivisto, Jyväskylän ammattikorkeakoulu TyhyTeko-podcast tuotetaan osana TyhyTeko – Työhyvinvointia ja tuottavuutta marata-alan ammattilaisille tekoälyn ja robotiikan avulla -hanketta. TyhyTeko-hanke on Euroopan unionin osarahoittama hanke, jota toteuttamassa ovat Jyväskylän, Kaakkois-Suomen, Lapin, Savonia-, Seinäjoen ja Tampereen ammattikorkeakoulut. Hankkeen tarkoituksena on marata-alan ammattilaisten työhyvinvoinnin ja tuottavuuden parantaminen sekä työn tehostaminen tekoälyn ja robotiikan käyttöönoton avulla. Lue lisää hankkeesta: www.jamk.fi/tyhyteko Jakson tekstivastine: https://www.savonia.fi/app/uploads/2026/04/Jakso-8_tekstivastine_TyhyTeko-podcast.pdf

Behind every kidney cancer diagnosis is a person navigating difficult decisions about treatment and care. Today, we're diving into how to navigate the side effects of kidney cancer treatments and how to tell the difference between side effects and warning signs. This episode is supported by Exelixis.  In this episode we heard from:  Andrew Allers was diagnosed incidentally with clear-cell Renal Cell Carcinoma (RCC) in 2015 after a soccer injury. After a radical nephrectomy and four years of monitoring, Andrew's stage IV diagnosis was made in 2019 with metastases in his rib, hip, lungs and lymph nodes. The bone tumors were radiated, and after two rounds of an immunotherapy combination, a serious auto-immune reaction necessitated a pause in treatment while Andrew's care team figured out a solution. With regular IVIG infusions to manage the adverse reactions, a single-agent immunotherapy was restarted in early 2020 and within a few months a set of scans showed remarkable improvement -- tumors still visible, but "clinically unmeasurable" in the words of his oncologist. Just over a month later, a vision issue took Andrew to the local ER where he was diagnosed with two brain metastases, one of which was in the occipital lobe. The following day an emergency craniotomy was performed, followed by a round of brain radiation. Over the next 18 months, a series of 4 more brain tumors were discovered, radiated and added to the monitoring schedule. Since beginning a TKI in 2022 Andrew has been free of new brain metastases, and the immunotherapy continues to keep the lung and lymph node tumors at bay. After retiring in 2023, Andrew has become active in the Kidney Cancer community, participating in the research grant review process in the CDMRP & KCRP and as a Legislative Advocate for KidneyCAN, an advocacy group that campaigns for federally funded research into Kidney Cancer treatments. Julia Stevens, PharmD, BCOP  is a Clinical Pharmacy Specialist in Ambulatory Oncology at Beth Israel Deaconess Medical Center in Boston, MA. She collaborates with medical oncologists to care for patients with kidney cancer. Her primary clinical responsibilities include educating patients and caregivers, monitoring and supporting those on oral therapies, minimizing the financial toxicity of treatment, and providing drug information and treatment recommendations to her team. Dr. Stevens is also a member of the Kidney Cancer Association Clinical Advisory Board. Rimda Wanchoo, MD is a Professor of Medicine at the Zucker School  of Medicine and full time nephrologist at Northwell Health in NY. She graduated from medical school in India followed by residency at St. Barnabas in New Jersey and fellowship at NY Presbyterian at Weill Cornell.  Her interests are taking care of patients with cancer and kidney diseases, glomerular disease and end stage kidney disease. She has been at Northwell for the last 14 years . She also serves as director of quality for the division and medical director of the largest joint venture dialysis unit in the health system. She has published and spoken on several onconephrology topics internationally. She serves as an associate editor for JON and CKJ. She is one of the founding members of American Society of Onconephrology (ASON).   Additional Resources Kidney Cancer  Kidney Cancer: Treatment and Living Well  Voices for Kidney Health  Kidney Cancer Association (KCA)  KidneyCAN    Do you have comments, questions, or suggestions? Email us at NKFpodcast@kidney.org. Also, make sure to rate and review us wherever you listen to podcasts.

Back a Lich into a corner and see what happens...www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

With The Ghast Bears Defeated The Party enters a room with a far more dangerous occupants...www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

CME credits: 0.25 Valid until: 31-03-2027 Claim your CME credit at https://reachmd.com/programs/cme/navigating-today-and-shaping-tomorrow-in-ism-personalized-strategies-with-current-and-emerging-kit-inhibitors/54388/ This online educational activity explores the evolving role of KIT-targeted tyrosine kinase inhibitors (TKIs) in indolent systemic mastocytosis (ISM). Expert faculty discuss pivotal clinical data supporting the approval of avapritinib, a potent TKI that targets KIT D816V, in patients with ISM. They also highlight emerging clinical evidence on next-generation KIT TKIs, such as elenestinib and bezuclastinib, that are designed for enhanced selectivity and minimal brain penetration. Finally, faculty discuss how these agents may be sequenced and integrated into a personalized, multidisciplinary treatment approach aimed at durable symptom control and improved quality of life for patients with ISM.=

2 Ghastly Bears down 2 to go, But these Undead aernt done yet!www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

The ghastly Bears seem to sense the tactics of the Party and try to adapt as best they can under the unknown restraints they endure...www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Sarah: Hi Dr. Cabral. Thank you for all you do! Every time I get a cold or virus I break out in full body hives and it takes my body weeks to reset. I've tried your 21DD but seem to be really sensitive to herbal supplements. (Lots of reactions) Please help!      Mohamed: Hey Dr.Cabral, 2 part question. Firstly, how are you? Where are you in terms of your overall well-being. I know you get a lot of baggage trying to help others! Just wanted to let you know You helped me a lot. Thought I'd ask, how is your well-being. My secondary question is about water pH, I have an under sink AquaTru without the alkaline remineralization. I sometimes add mineral drops.. wondering about optimal pH range for water. No Kangen yet haha it's expensive for a college student!      Jenny: Hi Dr. Cabral - I know you have given recommendations in the past for the community to look into biological dentists, especially when it comes to removing past fillings, alternatives to root canals, etc. What about for regular 6 month check ups and cleanings? If we continue to go to a "regular" dentist for those visits, what is your recommendation about the dental x-rays they require? Thank you!     Anonymous:  Hi Dr. Cabral - I have a question about eye health. My father had Glaucoma which eventually led to full blindness. His eye doctor prescribed multiple eye drops to help maintain the eye pressure to help delay the progression, but he was on those for probably 20-30 years (Lumigan, Alphagan, Cosopt). My eye doctor is watching the pressure in my eyes and would like me to begin drops, as the pressure is higher than the "normal" range. I don't want to use drops, but also want to maintain eye health. I follow your protocols, including 2 Omega 3 soft gels and the Daily Vision and Eye Health. Do you have any other recommendations? Is Inflamma Soothe something I should take on an ongoing basis, as well? Thank you for all that you do.      Dyan: Hello! Thank you so much for all you do! My boyfriend was diagnosed at 26 with Chronic Myeloid Leukemia, with him being so young there are great chances he will go into remission in five years or so and stop his medication. Doctors say CML is a genetic mutation but I know most cancers are from environmental factors. He's taking 50mg of a TKI inhibitor pill daily (considered chemo). I don't feel confident enough in my knowledge to have him stop his chemo pill just yet, but I know we would both love for him to stop it. What is your thought on Ivermectin for cancers patients? I have read it would respond great with his medication. He is super open to anything I've suggested whether it's diet changes or supplements. What supplements or action should we be sure to take?    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3684 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Goldie locks and the three undead bears would have been its own story!www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

CME credits: 0.75 Valid until: 04-03-2027 Claim your CME credit at https://reachmd.com/programs/cme/The-Struggle-Is-Real/54098/ This activity examines the evolving role of tyrosine kinase inhibitors (TKIs) in treating exudative retinal diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Experts discuss limitations of current anti-VEGF therapies, emphasizing challenges with durability and adherence. The series further explores TKI mechanisms and their formulation into sustained-release delivery systems. Detailed overviews of clinical programs (eg, LUGANO, LUCIA, SOL-1, SOL-R) highlight ongoing phase 3 studies evaluating efficacy and treatment intervals. Real-world case discussions further illustrate patient types who may benefit from these investigational agents. The conversation concludes with considerations for integrating TKIs into future practice. *Please stay tuned for additional content to this activity available for credit. The maximum amount of credit(s) available for the entire activity is 0.75.

CME credits: 0.75 Valid until: 04-03-2027 Claim your CME credit at https://reachmd.com/programs/cme/TKI-The-New-TKO-for-Retinal-Diseases/54099/ This activity examines the evolving role of tyrosine kinase inhibitors (TKIs) in treating exudative retinal diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Experts discuss limitations of current anti-VEGF therapies, emphasizing challenges with durability and adherence. The series further explores TKI mechanisms and their formulation into sustained-release delivery systems. Detailed overviews of clinical programs (eg, LUGANO, LUCIA, SOL-1, SOL-R) highlight ongoing phase 3 studies evaluating efficacy and treatment intervals. Real-world case discussions further illustrate patient types who may benefit from these investigational agents. The conversation concludes with considerations for integrating TKIs into future practice. *Please stay tuned for additional content to this activity available for credit. The maximum amount of credit(s) available for the entire activity is 0.75.

CME credits: 0.75 Valid until: 04-03-2027 Claim your CME credit at https://reachmd.com/programs/cme/To-Implant-or-to-Inject/54100/ This activity examines the evolving role of tyrosine kinase inhibitors (TKIs) in treating exudative retinal diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Experts discuss limitations of current anti-VEGF therapies, emphasizing challenges with durability and adherence. The series further explores TKI mechanisms and their formulation into sustained-release delivery systems. Detailed overviews of clinical programs (eg, LUGANO, LUCIA, SOL-1, SOL-R) highlight ongoing phase 3 studies evaluating efficacy and treatment intervals. Real-world case discussions further illustrate patient types who may benefit from these investigational agents. The conversation concludes with considerations for integrating TKIs into future practice. *Please stay tuned for additional content to this activity available for credit. The maximum amount of credit(s) available for the entire activity is 0.75.

CME credits: 0.75 Valid until: 04-03-2027 Claim your CME credit at https://reachmd.com/programs/cme/Who-Needs-a-TKI-Identifying-the-Right-Candidates/54101/ This activity examines the evolving role of tyrosine kinase inhibitors (TKIs) in treating exudative retinal diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Experts discuss limitations of current anti-VEGF therapies, emphasizing challenges with durability and adherence. The series further explores TKI mechanisms and their formulation into sustained-release delivery systems. Detailed overviews of clinical programs (eg, LUGANO, LUCIA, SOL-1, SOL-R) highlight ongoing phase 3 studies evaluating efficacy and treatment intervals. Real-world case discussions further illustrate patient types who may benefit from these investigational agents. The conversation concludes with considerations for integrating TKIs into future practice. *Please stay tuned for additional content to this activity available for credit. The maximum amount of credit(s) available for the entire activity is 0.75.

CME credits: 0.75 Valid until: 04-03-2027 Claim your CME credit at https://reachmd.com/programs/cme/So-You-Think-You-Want-a-TKI/54102/ This activity examines the evolving role of tyrosine kinase inhibitors (TKIs) in treating exudative retinal diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema (DME). Experts discuss limitations of current anti-VEGF therapies, emphasizing challenges with durability and adherence. The series further explores TKI mechanisms and their formulation into sustained-release delivery systems. Detailed overviews of clinical programs (eg, LUGANO, LUCIA, SOL-1, SOL-R) highlight ongoing phase 3 studies evaluating efficacy and treatment intervals. Real-world case discussions further illustrate patient types who may benefit from these investigational agents. The conversation concludes with considerations for integrating TKIs into future practice. *Please stay tuned for additional content to this activity available for credit. The maximum amount of credit(s) available for the entire activity is 0.75.

What do sharks, owls, teddy bears, turtles, and foxes have to do with conflict?In this episode, Victoria dives into the fascinating world of conflict management styles using the Thomas-Kilmann Conflict Mode Instrument (TKI). With honesty, humour, and a little vulnerability, they uncover how each of them instinctively responds when tension rises.The Academy Awards are coming up, so you know what this means… DISC as OSCARS nominated films!High D – One Battle After Another: High stake conflict, intense energyHigh I – F1: Fun, thrillingHigh S – Hamnet: Familial relationships, emotional depthHigh C – The Secret Agent: Layered details, deductive reasoningWhich one do you think will win?The conversation shifts into something deeper: How do you actually handle disagreement? Do you power through it? Smooth it over? Walk away? Or try to meet in the middle?You'll hear:A breakdown of all five conflict styles (Competing, Collaborating, Accommodating, Avoiding, Compromising)How assertiveness and cooperation shape your reactionsReal-life reflections on boundaries, people-pleasing, and “Is this a hill I want to die on?”Why no style is inherently good or bad — and how awareness gives you optionsIf conflict drains you, confuses you, or sometimes defines you, this episode will help you recognize your default patterns — and empower you to respond more intentionally next time.Because understanding your style doesn't box you in. It gives you leverage.Episode Timestamps:00:26 - Welcome and introduction to Discovering You podcast00:45 - Mood check-in: Yellow (exhilarated) vs Blue (tired)02:11 - Introduction to conflict management styles and Oscar-nominated films as DISC types02:57 - Overview of Dr. Ralph Kilman's TKI assessment model03:37 - Sample assessment questions walkthrough05:31 - Revealing personal conflict style results09:09 - Deep dive into the five conflict styles begins12:00 - Competing style (Shark) - High assertiveness, low cooperation13:54 - Collaborating style (Owl) - High assertiveness, high cooperation15:25 - Accommodating style (Teddy Bear) - Low assertiveness, high cooperation16:57 - Avoiding style (Turtle) - Low assertiveness, low cooperation20:01 - Compromising style (Fox) - Moderate assertiveness and cooperation21:29 - Discussion on win-win vs zero-sum mindsets in conflict22:00 - Key takeaways: Using awareness to choose appropriate conflict styles22:44 - Closing and creditsIf you're interested in learning more about team building, coaching, strategic hiring and onboarding, let's connect!discoverwhatworks@gmail.comhttps://pod.link/1614071253https://discoverwhatworks.org/https://www.facebook.com/VictoriaDISChttps://www.instagram.com/discoverwhatworks/https://www.linkedin.com/in/discoverwhatworksMentioned in this episode:Fast Facts

In today's episode, we welcomed Quinto Gesiotto, MD, a malignant hematologist at Tampa General Hospital in Florida.In the exclusive interview, Dr Gesiotto explored the evolving role of TKIs in the treatment of patients with chronic myeloid leukemia (CML), including dosing patterns for ponatinib (Iclusig) in those with CML and other TKI data to emerge in the CML space at the 2025 ASH Annual Meeting and Exposition. Dr Gesiotto also provided detail on emerging data on novel strategies and agents, along with genetic mutations beyond BCR-ABL1 T315I the could drive more personalized treatment sequencing and improved risk stratification in CML in the future. 

www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

The Giants Fall 1 by 1www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

In today's episode, we spoke with Nicholas Short, MD. Dr Short is an associate professor in the Department of Leukemia of the Division of Cancer Medicine at the University of Texas MD Anderson Cancer Center in Houston.In our exclusive interview, Dr Short discussed evolving factors at play for the treatment of patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). He also noted how the TKI ponatinib (Iclusig) stacks up against other TKIs for Ph-positive ALL, in addition to evolving approaches that incorporate treatments like blinatumomab (Blincyto).

Have you ever wondered what the Monsters are doing before the party arrives?www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"Edvard Grieg Peer Gynt Suite no 1 morning mood written in 1875 as incidental music to Henrik Ibsen's play of the same name, and was also included as the first of four movements in Peer Gynt Suite No. 1, Op. 46. Free classical music for youtube videos. Most popular classical songs download. Commercial use allowed.Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

With Dwarven thugs spilling in from the next room things get interesting.www.Rollmonger.comRoll Mongers Merch!Support us On Patreon!Cast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"A few seconds Clip from :(I've Had) The Time of My Life (From "Dirty Dancing" Soundtrack)Bill Medley, Jennifer WarnesMakai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

In this update, we review the TKI program of Eyepoint Pharmaceuticals with Dr. Jay Duker, President and CEO.

Oh no fights draw more attention from adjacent rooms!http://www.rollmonger.comhttp://www.TeeSpring.com/RollMongershttp://www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. http://affiliates.fantasygrounds.com/370352/15958http://affiliates.fantasygrounds.com/370352/15958https://podcast.feedspot.com/pathfinder_roleplaying_game_podcasts/Music: (Evan King) Intro/Outro: "Singularity"A few seconds Clip from :(I've Had) The Time of My Life (From "Dirty Dancing" Soundtrack)Bill Medley, Jennifer WarnesMakai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

Dr. Monty Pal and Dr. Hope Rugo discuss advances in antibody-drug conjugates for various breast cancer types as well as treatment strategies in the new era of oral SERDs for HR-positive breast cancer. TRANSCRIPT Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. Monty Pal. I'm a medical oncologist and vice chair of academic affairs here at the City of Hope Comprehensive Cancer Center, Los Angeles. Today, I'm thrilled to be joined by Dr. Hope Rugo, an internationally renowned breast medical oncologist and my colleague here at City of Hope, where she leads the Women's Cancers Program and serves as division chief of breast medical oncology. Dr. Rugo is going to share with us exciting advances in antibody-drug conjugates (ADCs) that are expanding treatment options in various breast cancer types. She'll also address some of the complex questions arising in the new era of oral SERDs (selective estrogen receptor degraders) that are revolutionizing treatment in the hormone receptor-positive breast cancer space. Our full disclosures are available in the transcript of this episode.  Dr. Rugo, welcome, and thanks so much for being on the podcast today. Dr. Hope Rugo: Thank you. Pleasure to be here. Dr. Monty Pal: So, I'm going to switch to first names if you don't mind.  The first topic is actually a really exciting one, Hope, and this is antibody-drug conjugates. I don't know if I've ever shared this with you, but I actually started my training at UCLA, I was a med student and resident there, and it was in Dennis Slamon's lab. I worked very closely with Mark Pegram and a handful of others. This is right around the time I think a lot of HER2-directed therapies were really evolving initially in the clinics. Now we've got antibody-drug conjugates. Our audience is well-familiar with the mechanism there but tell us about how ADCs have really started to reshape therapy for HER2-positive breast cancer. Dr. Hope Rugo: Yeah, I mean, this is a really great place to start. I mean, we have had such major advances in breast cancer just this year, I think really changing the paradigm of treating patients. But HER2-positive disease, we've been used to having sequenced success of new agents. And I think the two biggest areas where we've made advances in HER2-positive disease, which were remarkably advanced this year in 2025, have been in antibody-drug conjugates with trastuzumab deruxtecan and with new oral tyrosine kinase inhibitors (TKIs) that have less of a target on EGFR and more on HER2, so they have an overall more tolerable toxicity profile and therefore a potentially better efficacy in the clinic. At least that's what we're seeing with these new strategies that we couldn't really pursue in the past because of toxicities of the oral TKIs. So, although our topic is ADCs, I'm going to include the TKI because it's so important in our thinking about treating HER2-positive disease. In the metastatic setting, we've seen these remarkable improvements in progression-free and overall survival in the second-line setting with T-DXd, or trastuzumab deruxtecan, compared to T-DM1. And then sequencing ADCs with giving T-DXd after T-DM1 was better than an oral tyrosine kinase or a trastuzumab combination with standard chemotherapy. That was DESTINY-Breast03 and DESTINY-Breast02. So, then we've had other trials since then, and T-DXd has moved into the early-stage setting, which I'll talk about in just a moment. But the next big trial for T-DXd in HER2-positive disease was moving it to the first-line setting to supplant what has become an established treatment for now quite a long time: the so-called CLEOPATRA regimen, which used the combined antibodies trastuzumab, pertuzumab with a taxane as first-line therapy. And then we've proceeded on with maintenance with ongoing HP for patients with responding or stable disease. And we'd seen long-term data showing, you know, at 8 years there was a group of patients whose cancers had never progressed and continued improved overall survival. So, T-DXd was studied in DESTINY-Breast09, either alone or in combination with pertuzumab compared to THP. The patient population had received a little bit more prior treatment, but interestingly, not a lot compared to CLEOPATRA. And they designed the trial to be T-DXd continued until progression with or without pertuzumab versus THP, which would go for six cycles and then stop around six cycles, and then stop and continue HP. Patients who had hormone receptor-positive disease could use hormone therapy, and this is one of the issues with this dataset because, surprisingly in this dataset and one other I'll mention, very few patients took hormone therapy. And even in the maintenance trial, the HER2CLIMB-05, less than 50% took hormone therapy as maintenance. This is kind of shocking to me and highlights an area of really important education, that outcome is improved when you add endocrine therapy for hormone receptor-positive HER2-positive metastatic disease in the maintenance phase, and it's a really important part of treatment. But suffice it to say, you know, you're kind of studying continued chemo versus stopping chemo in maintenance. And T-DXd, as we all expected, in combination with pertuzumab was superior to THP in terms of progression-free survival, really remarkably improved. And you could stop the chemo with toxicity, but most people continued it with T-DXd. Again, not a lot of people got hormone therapy, which is an issue, and you stop the chemo in the control arm. So, this has brought up a lot of interest in trying to use T-DXd as an induction and then go to maintenance, much as we do with the CLEOPATRA regimen with hormone therapy. But it brings up another issue. So first, T-DXd is superior; it's a great treatment. Not everybody needs to have it because we don't know whether it's better to give T-DXd first or second with progression - that we need a little bit longer follow-up. But just earlier this week, interestingly, the third week of December, the U.S. FDA approved T-DXd in the DESTINY-Breast09 approach with pertuzumab. So as I mentioned earlier, there was a T-DXd-alone arm; that arm has not yet reported. So very interesting, we don't know if you need pertuzumab or not. So what about the maintenance? That's the other area where we've made a huge advance here. So, we all want to stop chemo and we want to stop T-DXd. You don't want somebody being nauseated for two years while they're on treatment, and also there's a small number of patients with mostly de novo metastatic HER2-positive disease who are cured of their disease. We'd like to expand that, and I think these new drugs give us the opportunity to improve the number of patients who might be cured from metastatic disease. So the first maintenance study we saw was adding palbociclib, the CDK4/6 inhibitor, to endocrine therapy and HP, essentially. There, we had a remarkable improvement in progression-free survival difference of 15.2 months: 29 to 44 months, really huge. At San Antonio this year, we saw data with this oral tyrosine kinase inhibitor tucatinib, already showed it was great in a triplet, but as maintenance in combination with HP, it showed also a remarkable improvement in progression-free survival. But the numbers were all shifted down. So in PATINA, the control arm was in the 24-month range; here it was the tucatinib-HP arm that was in the 25 months and 16 months for control. So there was a differential benefit in ER-negative and ER-positive disease. So I think we're all thinking that our ideal approach moving forward would be to give T-DXd to most patients, we see how they do, and treat to best response. And then, stop the T-DXd, start HP, trastuzumab, pertuzumab for ER-negative, with tucatinib for ER-positive with palbociclib. We also have early data that suggests that both approaches may reduce the development of brain metastases, an issue in HER2-positive disease, and delay time to progression of brain metastases as seen in HER2CLIMB-05 in very early data - small numbers, but still quite intriguing that you might delay progression of brain metastases with tucatinib that clearly has efficacy in the brain.  So, I think that this is a hugely exciting advance for our patients, and these approaches are quickly moving into the early stage setting. T-DXd compared to standard chemo, essentially followed by THP, so a sequenced approach resulted in more pathologic complete responses than a standard THP-AC-type neoadjuvant therapy. T-DXd alone for eight cycles wasn't better, and that's interesting. We still need the sequenced non-cross-resistant chemo. But I think even more importantly, the data from DESTINY-Breast05 looking at T-DXd versus T-DM1 in patients with residual disease after neoadjuvant HER2-targeted therapy showed a remarkable improvement in invasive disease-free survival with T-DXd versus T-DM1, and quite early. It was a high-risk population, higher risk than the T-DM1 trial with KATHERINE, but earlier readout with a remarkable improvement in outcome. We expect to be FDA approved sometime in the first half of 2026. So then we'll get patients who've already had T-DXd who get metastatic disease. But my hope is that with T-DXd, maybe with tucatinib in the right group of patients or even sequenced in very high-risk disease, that we could cure many more patients with early-stage HER2-positive breast cancer and cure a subset, a greater subset of patients with de novo metastatic disease. Dr. Monty Pal: That's brilliant. And you tackled so many questions that I was going to follow up with there: brain metastases, etc. That was sort of looming in my mind. I mean, general thoughts on an ADC versus a TKI in the context of brain mets? Dr. Hope Rugo: Yeah, it's an interesting question because T-DXd has shown quite good efficacy in this setting. And tucatinib, of course, had a trial where they took patients with new brain mets, so a larger population than we've seen yet for the T-DXd trials, and saw that not only did they delay progression of brain metastases and result in shrinkage of existing untreated brain mets, but that patients who develop a new brain met, they could stay on the same assigned treatment. They got stereotactic radiation, and then the patients who were on tucatinib with trastuzumab and capecitabine had a further delay in progression of brain mets compared to those on the placebo arm, even after treatment of a new one that developed on treatment. So, I think it's hard. I think most of us for a lot of brain mets might start with the tucatinib approach, but T-DXd is also a very important treatment. You know, you're kind of trading off a diarrhea, some liver enzyme elevations with tucatinib versus nausea, which you really have to work on managing because it can be long-delayed nausea, and this risk of ILD, interstitial lung disease, that's about 12%, with most but not all trials showing a mortality rate from interstitial lung disease of just under 1 percent. In the early-stage setting, it was really interesting to see that with T-DXd getting four cycles in the neoadjuvant setting, a lot less ILD noted than the patients who got up to 14 cycles, as I think they got a median of 10 cycles in the post-surgical setting, there was a little bit more ILD. But I think we're going to be better and better at finding this earlier and preventing mortality by just stopping drug and treating earlier with steroids. Dr. Monty Pal: And this ILD issue, it always seems to resurface. There are drugs that I use in my kidney cancer clinic, everolimus, common to perhaps the breast cancer clinic as well, pembrolizumab, where I think the pattern of pneumonitis is quite different, right? What is your strategy for recognizing pneumonitis early in this context? Dr. Hope Rugo: Well, it is, and you know, having done the very early studies in everolimus where we gave it in the neoadjuvant setting and we're like, "Hmm, the patient came in with a cough. What's going on?" You know, we didn't know. And you have mouth sores, you know, we were learning about the drug as we were giving it. What we don't do with everolimus and CDK4/6 inhibitors, for example, is grade 1 changes like radiation pneumonitis, we don't stop, we don't treat it. We only treat for symptoms. But because of the mortality associated with T-DXd, albeit small, we stop drug for grade 1 imaging-only asymptomatic pneumonitis, and some of us treat with a half dose of steroids just to try and hasten recovery. We've actually now published or presented a couple of datasets from trials, a pooled analysis and a real-world analysis, that have looked at patients who were retreated after grade 1 pneumonitis or ILD and tolerated drug very well and none of them died of interstitial lung disease, which was really great to see because you can retreat safely and some of these patients stayed on for almost a year benefiting from treatment. So, there's a differential toxicity profile with these drugs and there are risk factors which clearly have identified those at higher risk: prior ILD, for example. A French group said smoking; other people haven't found that, maybe because they smoked more in France, I don't know. And being of Japanese descent is quite interesting. The studies just captured that you were treated in Japan, but I think it's probably being of Japanese descent with many drugs that increases your risk of ILD. And, you know, older patients, people who have hypoxia, those are the patients. So, how do we do this? With everolimus, we don't have specific monitoring. But for T-DXd we do; we do every nine weeks to start with and then every 12 weeks CT scans because most of the events occur relatively early. Somebody who's older and at higher risk now get the first CT at six weeks. Dr. Monty Pal: This is super helpful. And I have to tell you, a lot of these drugs are permeating the bladder cancer space which, you know, is ultimately going to be a component of my practice, so thank you for all this. We could probably stay on this topic of HER2-positive disease forever. I'm super interested in that space still. But let me shift gears a little bit and talk about triple-negative breast cancer and this evolving space of HR-positive, HER2-low breast cancer. I mean, tell us about ADCs in that very sort of other broad area. Dr. Hope Rugo: So triple-negative disease is the absolute hardest subset of disease that we have to treat because if you don't have a great response in the early stage setting, the median survival is very short, you know, under two years for the majority of TNBCs, with the exception of the small percentage of low proliferative disease subsets. The co-question is what do we do for these patients and how do we improve outcome? And sacituzumab govitecan has been one strategy in the later line setting that was shown to improve progression-free and overall survival, the Trop-2 ADC. We had recently three trials presented with the two ADCs, sacituzumab govitecan and the other Trop-2 ADC that's approved for HR-positive disease, datopotamab deruxtecan. And they were studied in the first-line setting. Two trials with SG, sacituzumab govitecan, those trials, one was PD-L1 positive, ASCENT-04. That showed that SG with a checkpoint inhibitor was superior, so pembrolizumab was superior to the standard KEYNOTE-355 type of treatment with either a taxane or gemcitabine and carboplatin with pembrolizumab for patients who have a combined positive score for PD-L1, 10 or greater. So, these are patients who are eligible for a checkpoint inhibitor, and SG resulted in an improved progression-free survival.  The interesting thing about that dataset is that few patients had received adjuvant or neoadjuvant checkpoint inhibitor, which is fascinating because we give it to everybody now. But access is an issue and timing of the study enrollment was an issue. The other thing which I think we've all really applauded Gilead for is that there was automatic crossover. So, you could get from the company, to try and overcome some of the enormous disparities worldwide in access to these life-saving drugs, you could get SG through the company for free once you had blinded independent central review confirmation of disease progression. Now, a lot of the people who got the SG got it through their insurance, they didn't bill the company, but 80 percent of patients in the control arm received SG in the second-line setting. So that impacts your ability to look at overall survival, but it's an incredibly important component of these trials. So then at ESMO, we saw the data from SG and Dato-DXd in the first-line metastatic setting for patients who either had PD-L1-negative disease or weren't eligible for an immunotherapy. For the Dato study, TROPION-Breast02, that was 10 percent of the patients who had PD-L1-positive disease but didn't get a checkpoint inhibitor, and for the ASCENT-03 trial population it was only 1 percent. Importantly, the trials allowed patients who relapsed within a year of receiving their treatment with curative intent, and the Dato study, TB-02, allowed patients who relapsed while on treatment or within the first six months, and that was 15 percent of the 20 percent of early relapsers. The ASCENT trial, ASCENT-03, had 20 percent who relapsed between 6 and 12 months. The drugs were better than standard of care chemotherapy, the ADCs in both trials, which is very nice. Different toxicity profiles, different dosing intervals, but better than standard of care chemotherapy in the disease that's hardest for us to treat. And importantly, when you looked at the subset of early relapsers, those patients also did better with the ADC versus chemotherapy, which is incredibly important. And we were really interested in that 15 percent of patients who had early relapse. I actually think that six months thing was totally contrived, invented, you know, categorization and doesn't make any sense, and we should drop it. But the early relapsers were 15 percent of TB-02 and Dato was superior to standard of care chemo. We like survival, but the ASCENT trial again allowed the crossover to an approved ADC that improved survival and 80 percent of patients crossed over. In the Dato trial, they did not allow crossover, they didn't provide Dato, which isn't approved for TNBC but is for HR-positive disease, and they didn't allow, of course, pay for SG. So very few patients actually crossed over in their post-treatment data and in that study, they were able to show a survival benefit. So actually, I think in the U.S. where we can use approved drugs already before there's a fixed FDA approval, that people are already switching to use SG or Dato in the first-line setting for metastatic TNBC that's both PD-L1 positive for SG and PD-L1 negative for both drugs. And I think understanding the toxicity profiles of the two drugs is really important as well as the dosing interval to try and figure out which drug to use. Dr. Monty Pal: Brilliant. Brilliant. Well, I'm going to shift gears a little bit. ADCs are a topic, again, just like HER2-positive disease we could stay on forever. Dr. Hope Rugo: Huge. Yes. Dr. Monty Pal: But we're going to shift gears to another massive topic, which is oral SERDs. In broad strokes, right, this utilization of CDK4/6 inhibitors in the context of HR-positive breast cancer is obviously, you know, a paradigm that's been well established at this point. Where do we sequence in oral SERDs? Where do they fit into this paradigm? Dr. Hope Rugo: Ha! This is a rapidly changing area; we keep changing what we're saying every other minute. And I think that there are three areas of great interest. So one is patients who develop ESR1 mutations that allow constitutive signaling through the estrogen receptor, even when there's not estrogen around, and that is a really important mutation that is subclonal; it develops under the pressure of treatment in about 40 percent of patients. And it doesn't happen when you first walk in the door. And what we've seen is that oral SERDs as single agents are better than standard single-agent endocrine therapy in that setting. The problem that we've had with that approach is that we're now really interested in giving targeted agents with our endocrine therapies, not just in the first-line setting where CDK4/6 inhibitors are our standard of care with survival benefit for ribociclib and, you know, survival benefit in subsets with other CDK4/6 inhibitors, and abemaciclib with a numeric improvement. So we give it first line. The question is, what do you do in the second-line setting? Because of the recent data, we now believe that oral SERDs should be really given with a targeted agent. And some datasets which were recently presented, which I think have helped us with that, have been EMBER-3 and then the most recently evERA BC, or evERA Breast Cancer, that looked at the oral SERD giredestrant with everolimus compared to standard of care endocrine therapy with everolimus, where 100 percent of patients received prior CDK4/6 inhibitor and showed a marked improvement in progression-free survival, including in the subsets of patients with a short response, 6-12 months of prior response to CDK4/6 inhibitor and in those who had a PIK3CA pathway mutation. The thing is that the benefit looks like it's much bigger in the ESR1 mutant population, although response was better, PFS wasn't better in the wild type. So, we're still trying to figure that out. We also saw EMBER-3 with imlunestrant and abemaciclib as a second line. Not everybody had had a prior CDK4/6 inhibitor; they compared it to imlunestrant alone, but still the data was quite striking and seemed to cross the need for ESR1 mutations. And then lastly, we saw data from the single arms of the ELEVATE trial looking at elacestrant with everolimus and abemaciclib and showed these really marked progression-free survival data, even though single-arm, that crossed the mutation status. At least for the everolimus combination, abemaciclib analysis is still to come in the mutated subgroups. But really remarkable PFS, much longer.  Single-agent fulvestrant after CDK4/6 inhibitor AI has a PFS in like the three-month range and in some studies, maybe close to five months. These are all at 10-plus months and really looking very good. And so those questions are, is it ESR1 mutation alone? Is it all comers? We'd like all comers, right? We believe in the combination approach and we're learning more about combinations with drugs like capivasertib and other drugs as we move forward. Everybody now wants to combine their targeted agent with an oral SERD because they're clearly here to stay with quite remarkable data. The other issue, so the second issue in the metastatic setting is, does it make a difference if we change to an oral SERD before radiographic imaging evidence of progression? And that was the question asked in the SERENA-6 trial where patients had serial monitoring for the presence of ESR1 mutations in ctDNA. And those who had them without progression on imaging could be randomized to switch to camizestrant with the same CDK4/6 inhibitor or stay on their same AI CDK4/6 inhibitor. And they showed a difference in progression-free survival that markedly favored camizestrant. But interestingly, the people who were on the standard control arm had an ESR1 mutation, we think AIs don't work, they stayed on for nine more months. The patients who were on the camizestrant stayed on for more than 16 months. And they presented some additional subset data which showed the same thing: follow-up PFS data, PFS2, all beneficial in SERENA-6 at the San Antonio [Breast Cancer Symposium]. So, we're still a little bit unclear about that. They did quality of life, and pain was markedly improved. They had a marked delayed time to progression of pain in the camizestrant arm. So this is all a work in progress, trying to understand who should we switch without progression to an oral SERD based on this development of this mutation that correlates with resistance. And, you know, it's interesting because the median time to having a mutation was 18 months and the median time to switch was almost 24 months. And then there were like more than 3,000 patients who hadn't gotten a mutation, hadn't switched, and were still okay. So screening everybody is the big question, and when you would start and who you would change on and how this affects outcome. Patients didn't have access to camizestrant in the control arm, something we can't fix but we have experimental drugs. We're actually planning a trial, I hope in collaboration with the French group Unicancer, and looking at this exact question. You know, if you switch and you change the CDK4/6 inhibitor and then you also allow crossover, what will we see? Dr. Monty Pal: We're coming right to the tail end of our time here, and I could probably go on for another couple of hours with you here. But if you could just give us maybe one or two big highlights from San Antonio, any thoughts to leave our audience with here based on this recent meeting? Dr. Hope Rugo: Yeah, I mean, I talked about a lot of those new data already from San Antonio, and the one that I'd really like to mention which I think was, you know, there were a lot of great presentations including personalized screening presented from the WISDOM trial by my colleague Laura Esserman, fascinating and really a big advance. But lidERA was the big highlight, I think, outside of the HER2CLIMB-05 which I talked about earlier in HER2-positive disease. And this study looked at giredestrant, the oral SERD versus standard of care endocrine therapy as treatment for medium and high-risk early-stage breast cancer. And what they showed, which I think was really remarkable with just about a three-year median follow-up, was an improvement in invasive disease-free survival with a hazard ratio of 0.7. I mean, really quite remarkable and so early. It looked as though this was all driven by the high-risk group, which makes sense, not the medium risk, it's too early. And also that there was a bigger benefit in patients who were on tamoxifen compared to giredestrant versus AI, but for both groups, the confidence intervals didn't cross 1. There's even a trend towards overall survival, even though it's way too early. I think that, you know, really well-tolerated oral drug that could improve outcome in early-stage disease, this is the first advance we've seen in over two decades in the treatment of early-stage hormone receptor-positive disease with just endocrine therapy. I think we think that we don't want to give up CDK4/6 inhibitors because we saw a survival benefit with abemaciclib and a trend with giving ribociclib in the NATALEE trial. So we're thinking that maybe one approach would be to give CDK4/6 inhibitors and then switch to an oral SERD or to have enough data to be able to give oral SERDs with these CDK4/6 inhibitors for early-stage disease. And that's all in the works, you know, lots of studies going on. We're going to see a lot of data with both switching 8,000 patients with an imlunestrant switching trial, an elacestrant trial going on, and safety data with giredestrant with abemaciclib and soon to come ribociclib. So, this is going to change everything for the treatment of early-stage breast cancer, and I hope cure more patients of the most common subset of the most common cancer diagnosed in women worldwide. Dr. Monty Pal: Super exciting. It's just remarkable to hear how this has evolved since 25 years ago, which is really the last time I sort of dabbled in breast cancer.  Thank you so much, Hope, for joining us today. These were fantastic insights. Appreciate you being on the ASCO Daily News Podcast and really want to thank you personally for your remarkable contribution to the field of breast cancer. Dr. Hope Rugo: Thank you very much, and thanks for talking with me today. Dr. Monty Pal: You got it. And thanks a lot to our listeners today as well. You'll find links to all the studies we discussed today in the transcript of this episode. Finally, if you value the insights that you hear today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinion of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:   Dr. Monty Pal @montypal Dr. Hope Rugo   @hoperugo Follow ASCO on social media:        ASCO on X  ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:     Dr. Monty Pal:    Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview   Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical   Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis   Dr. Hope Rugo:    Honoraria: Mylan/Viatris, Chugai Pharma   Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer   Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx  

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"Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (https://incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audiohttps://Tabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongers Thank You For your needed Support! https://www.RollMonger.com https://www.TeeSpring.com/RollMongers for Merch! https://www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController •Become a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

In this episode, Dr John Heymach and Dr Solange Peters discuss key data presented at the IASLC World Conference on Lung Cancer including first-line maintenance in ES-SCLC (IMforte and DeLLphi-303 trials) and targeted treatment for NSCLC (FLAURA2, Beamion LUNG-1, and ARROS-1 trials).Presenters:John Heymach, MD, PhDChair and ProfessorDepartment of Thoracic/Head and Neck Medical OncologyRuth Legett Jones Distinguished ChairMD Anderson Cancer CenterHouston, TexasSolange Peters, MD, PhD Professor and Director of Medical OncologyDepartment of OncologyUniversity Hospital of LausanneLausanne, SwitzerlandContent based on an online CME program supported by independent educational grants from Boehringer Ingelheim Pharmaceuticals, Inc. and Jazz Pharmaceuticals, Inc.Link to full program: https://bit.ly/3L1eksIGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Two Onc Docs, hosted by Samantha A. Armstrong, MD, and Karine Tawagi, MD, is a podcast dedicated to providing current and future oncologists and hematologists with the knowledge they need to ace their boards and deliver quality patient care. Dr Armstrong is a hematologist/oncologist and assistant professor of clinical medicine at Indiana University Health in Indianapolis. Dr Tawagi is a hematologist/oncologist and assistant professor of clinical medicine at the University of Illinois in Chicago. In this episode, OncLive On Air® partnered with Two Onc Docs to highlight chronic lymphocytic leukemia (CLL) updates from the 2025 ASH Annual Meeting. Drs Armstrong and Tawagi noted that CLL is typically diagnosed in asymptomatic, elderly individuals presenting with lymphocytosis. A definitive diagnosis is established by confirming the clonality of circulating B lymphocytes via immunoglobulin light chain restriction on flow cytometry, they explained. Treatment initiation is reserved for active disease, which is indicated by B symptoms, progressive cytopenias, threatened organ function, or bulky disease such as splenomegaly, they said. They continued by reporting several prognostic features that denote poor outcomes. Current standard frontline regimens use covalent BTK inhibitors or time-limited targeted regimens that include venetoclax (Venclexta), often combined with an anti-CD20 monoclonal antibody, according to the experts. They added that TKI-based therapy is preferred for patients with high-risk features. The phase 3 BRUIN CLL-313 trial (NCT05023980) investigated pirtobrutinib (Jaypirca), a highly selective noncovalent BTK inhibitor, compared with bendamustine and rituximab (BR) in patients with treatment-naive CLL. The trial showed a significant improvement in progression-free survival with pirtobrutinib vs BR. Pirtobrutinib was also associated with a favorable safety profile, with modest rates of class-associated toxicities, including all-grade bleeding, arthralgia, and atrial fibrillation. Although pirtobrutinib showed superior efficacy in BRUIN CLL-313, the clinical interpretation of these data is complicated because BR is an outdated control arm compared with contemporary frontline standards, Armstrong and Tawagi emphasized. Furthermore, the requirement for indefinite therapy with BTK inhibitors is a sequencing challenge, particularly as pirtobrutinib is currently approved in the post-covalent BTK inhibitor setting, they continued. However, its favorable toxicity profile suggests potential utility in elderly patients with pre-existing cardiovascular comorbidities, they noted. Future studies are focused on comparing pirtobrutinib vs time-limited venetoclax and evaluating various triplet regimens, they concluded.

Up The river and into the town kinda with tangents...again...www.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"A few seconds Clip from :(I've Had) The Time of My Life (From "Dirty Dancing" Soundtrack)Bill Medley, Jennifer WarnesMakai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

We chat more and discuss boats and barges and mealswww.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

Can smarter strategies to tame retinal fluid fluctuations actually improve long-term vision? In episode 3 of this miniseries, host Jay Sridhar, MD, and panelists Durga Borkar, MD, MMCi, and Christina Weng, MD, MBA, examine the data linking sustained delivery of therapy, reductions in retinal thickness changes, and positive long-term vision outcomes. After the break, the trio looks ahead to sustained TKI therapy via EYP-1901 (Duravyu, EyePoint Pharmaceuticals) by examining data from the DAVIO-2 study. Drs. Sridhar, Borkar, and Weng are paid consultants of EyePoint Pharmaceuticals; however, the statements made are the opinions of Drs. Sridhar, Borkar, and Weng for educational purposes only; their statements are not intended as medical advice or the opinion of EyePoint.

In this episode of the Oncology Brothers podcast, we dive into the rapidly evolving landscape of renal cell carcinoma (RCC) treatment, focusing on second-line therapies. We were joined by Dr. David Braun, a GU Medical Oncologist from Yale University, to discuss two challenging real-life cases. We explored the current standard of care for metastatic RCC, including the use of immune-oncology (IO) therapies and tyrosine kinase inhibitors (TKIs). Dr. Braun shared insights on treatment options following disease progression, the importance of understanding disease biology, and the nuances of NCCN guidelines. Key topics included: • The role of TKI options like Axitinib, Cabozantinib, and Tivozanib in second-line treatment • The impact of disease progression on treatment decisions • Side effect management and the importance of palliative care • The potential use of HIF-2 alpha inhibitors like Belzutifan in specific scenarios Join us for an informative discussion that emphasized patient-centered care and the significance of shared decision-making in oncology.  Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ If you enjoy our conversations, please leave us a review and let us know what topics you'd like us to cover in future episodes! Stay tuned for more insights into the rapidly evolving field of cancer treatment. We are the Oncology Brothers! #RCC #KidneyCancer #TKI #Immunotherapy #OncologyBrothers #GUOncology

We are back with lots of OncoPharm updates: 1. The belantamab mafodotin REMS program details are available....and it's a lot. How will belantamab mafodin-regimens be used with the upcoming MAJESTIC-3 data of teclistamab-daratumumab? 2. The capecitabine label is updated and calls for pre-treatment DPYD testing 3. Daratumumab gets an FDA approval for high-risk smoldering myeloma based on the AQUILA study Critique of AQUILA: https://doi.org/10.1093/oncolo/oyaf216 4. A pertuzumab biosimilar (Poherdy) is approved 5. Epcoritamab nets regular approval and a new indication with lenalidomide/rituximab (RR) for Follicular Lymphoma 6. Ziftomenib, a new menin inhibitor, is approved for NPM1 relapsed/refractory AML 7. Sevabertinib, a new HER2 inhibiting TKI, is approved for ERBB2 mutated NSCLC, with evidence of activity in patients previously treated with HER2-antibody-drug conjugates 8. Expected FDA approvals for durvalumab + FLOT in preoperative gastric/GEJ cancer; neoadjuvant pembrolizumb + enforumab vedotin in bladder cancer (non-cisplatin eligible), and tarlatamab regular approval for small cell lung cancer 9. Happy Thanksgiving!

Using Downtime in Kintago and the cast just chattingwww.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

We level our crew to 11th, and chat, plan for the future!www.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

We level our crew to 11th, and chat, plan for the future!www.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

The TKI Crew keeps their Fall Season Rolling Along w/ another smash episode! On Today's Pod TKI's  Tori Corsaro is joined by GK Coach Faith Kempfer to discuss  the coaching college program at TKI, collegiate goalkeepers and what is similar or not to the youth environment. Great listen for young coaches, players and parents! Share your feedback! Send your comments or questions - contact@insidethe18media.com Video Link -https://www.theunionsports.com/feeds/2487937 And if you want to make sure you never miss an episode of any of our other fantastic  shows such as Gloves off w/ Saskia Webber & Inside the 18 w/ Michael Magid, all  you have to do is subscribe to the union gk app. For more info go to www.theuniongk.com or Download the Union GK Community, on apple or google play stores. Thanks for making The Union Possible & on with the show! *If you want us to come to your town; all you've got to do is DM us @goalkeeperpodcast on The Union & tell us what you've got in mind. The Following is a FREE Preview of the popular TKI Podcast. Want to continue watching or listening? Then Join a 30 day free trial of The Union GK App the new exclusive home of  the pod. For more info; go to www.theuniongk.com ; or download the The Union GK Community on Apple or Google Play Stores. Thanks for all your support & we'll see you on The Union!   Unlock Excellence with UNION GK APP Premium Features: One-On-One Virtual Coaching Sessions: Meet with world-class coaches and goalkeepers to discuss your performance, technical assessments, the college recruiting process, and more. Personalized Training Plans: Access to tailored training plans designed by professional goalkeepers to enhance skills and understanding of the position. Exclusive Drills Library: Unlimited access to the Union GK's goalkeeping drills and exercises Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of the Oncology Brothers podcast, we are joined by esteemed hematologists Dr. Onyee Chan from Moffitt Cancer Center and Dr. Fadi Haddad from MD Anderson to discuss the management of side effects associated with tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML). Join us as we delve into: • An overview of the different generations of TKIs, including imatinib, dasatinib, nilotinib, bosutinib, ponatinib, and asciminib. • Common class-wide toxicities such as fatigue, hypertension, gastrointestinal symptoms, and cytopenias. • Unique side effects associated with each TKI and strategies for dose optimization. • The importance of patient education and monitoring to ensure effective management of side effects. Don't forget to check out our other ToxCheck episodes on antibody drug conjugates, CAR-T therapies, and more! Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/ Subscribe to the Oncology Brothers for more discussions on bridging the gap between academic research and community practice in cancer care! #CML #TKI #ToxCheck #Hematology #OncologyBrothers #PrecisionMedicine

A roof top battle that barely touches the roof!www.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

The Party fight goes right out the window in this final tower boss fight!www.RollMonger.comwww.TeeSpring.com/RollMongers for Merch!www.Patreon.com/RollMongersCast:-Host/GM Jeff Ball -PlayersMatt WittRyan MessinaDoug Baldwin-Extended Cameos byAndrew MalBurgJoesph DavisJoe GibsonA Huge THANK YOU! To Our Patreon Supporters: "GrooveLord" & "ExploShawn" Matt Kenney, Daniel Harris, Allen Cooper Jr. Jered Mercer, "NarkMaul" Stephen Cahill (www.Patreon.com/RollMongers)Products through Our Affiliate link below. Roll Monger-Fantasy Groundshttp://affiliates.fantasygrounds.com/370352/15958Find us with Alll the top rated Podcasts here on FeedSpotMusic: (Evan King) Intro/Outro: "Singularity"Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b..."Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Too Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, FeywildMedevil Town,Cathedreal,Tavern Celebraton,Castle jail, Waterkeep, Desert Winds, Escape From Shadow, Black Rider, Tavern Music,Halfling Sneak,Blacksmith Shop, Forest Night,Raven Puff,Whispering Caverns, Country Village, Victorian Slums, Catacombs, ,Makai Symphony https://makai-symphony.bandcamp.com/a.... "Tafi Maradi"Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b...Kevin_MacLeod_-_Virtutes_InstrumentiVilon,Kevin_MacLeod_-_Sonatina,Kevin_MacLeod_-_Schmetterling,Kevin_MacLeod_-_Virtutes_InstrumentiVilon, Kevin_MacLeod_-_Trio_for_Piano_Violin_and_Viola, "Slow Heat" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Digya" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Kumasi Groove" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... "Monkoto" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/b... Lee_Maddeford_-_12_-_Tki_with_Les_Gauchers_OrchestraToo Cool kevin macloud Tabletop audioTabletopaudio.com"Xiengi Nights" CyberBar, Castle jail, Super Hero, Volcano, Jungle ruins, Medevil Market,Hell Hound Alley, Halfling Sneak, mansion Night,WaterKeep Nights,ravenpuff Commons, Tavern Music, metropolis fanfare, Sun Dappled trail, Through The Woods,The Hearth Inn, Feywild, Windswept plainsUploaded to You Tube @ The Roll mongers Podcast network "Bond Theme" Tom Schlueter https://soundcloud.com/tomschlueter/j... https://www.youtube.com/channel/UCc2w.... Evan King -- www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongers Thank You For your needed Support! www.RollMonger.com www.TeeSpring.com/RollMongers for Merch! www.Patreon.com/RollMongersReserved Material: Reserved Material elements in this product include all elements designated as Reserved Material under the ORC License. To avoid confusion, such items include: All trademarks, registered trademarks, proper nouns (characters, deities, locations, etc., as well as all adjectives, names, titles, and descriptive terms derived from proper nouns), artworks, characters, dialogue, locations, organizations, plots, storylines, and trade dress.Expressly Designated Licensed Material: This product contains no Expressly Designated Licensed Material.PAIZO INC.Creative Directors • James Jacobs and Luis LozaDirector of Game Design • Jason BulmahnDirector of Visual Design • Sonja MorrisDirector of Game Development • Adam DaigleManaging Creative Director (Starfinder) • Thurston HillmanLead Developers • James Case and John ComptonSenior Developers • Jessica Catalan, Eleanor Ferron, and Jenny JarzabskiDevelopers • Bill Fischer, Michelle Y. Kim, Mike Kimmel, Dustin Knight, and Landon WinklerLead Designer (Games) • Joe PasiniOrganized Play Line Developers • Josh Foster and Shay SnowDesign Manager • Michael SayrePathfinder Lead Designer • Logan BonnerSenior Designer • Jason KeeleyDesigners • Joshua Birdsong and Ivis K. FlanaganManaging Editor • Patrick HurleyLead Editor • Avi KoolSenior Editors • Ianara Natividad, Solomon St. John, and Simone D. SalléEditors • Felix Dritz, Priscilla Lagares, Lynne M. Meyer, and Zac MoranConcept Art Director • Kent HamiltonArt Directors • Kyle Hunter and Adam VickSenior Graphic Designer • Emily CrowellGraphic Designer • Adriana GasperiProduction Designer • Danika WirchDirector of Brand Strategy • Mark MorelandPaizo CEO • Lisa StevensPresident • Jim ButlerChief Creative Officer • Erik MonaVice President of People & Culture • Maggie GallagherVice President of Sales & Operations • Mike WebbVice President of Technology • Rei KoController • William JorenbyAccountant • Pasha JurgBecome a supporter of this podcast: https://www.spreaker.com/podcast/pathfinder-2e-age-of-ashes-the-elven-portal-podcast--4189253/support.

Tom Kobza owns TKI CNC in Billings, Montana. He is an avid angler and skilled manufacturer in multiple disciplines including the fishing industry where he produces premium rod holders, forward sonar pole mount kits as well as shuttles to name a few. Tom joins the JMO Podcast for the second time to share insights into the design and creation of TKI's products as well as recap some of the great fishing he's done this season.TKI CNC - https://www.youtube.com/@tkicnc6255 www.tkicnc.com

In today's episode, we had the pleasure of speaking with Alexander Drilon, MD, about the phase 1/2 ARROS-1 trial (NCT05118789) investigating zidesamtinib (NVL-520) in TKI-pretreated patients with advanced ROS1-positive non–small cell lung cancer (NSCLC). Dr Drilon is chief of the Early Drug Development Service at Memorial Sloan Kettering Cancer Center in New York, New York. In our exclusive interview, Dr Drilon discussed the efficacy data and implications of the ARROS-1 trial, highlighted the unique mechanism of action of zidesamtinib, noted the high central nervous system (CNS) response rates and favorable safety profile associated with the agent, and emphasized the potential for zidesamtinib to become a standard first-line therapy in the NSCLC treatment paradigm, especially for patients with prior TKI resistance or CNS disease.

“All of these TKIs [tyrosine kinase inhibitors] inhibit BCR-ABL1 in some way, shape, or form. When BCR-ABL1 is mutated, it has uncontrolled tyrosine kinase activity, leading to rapid cell proliferation. When we then inhibit that BCR-ABL1 that's been mutated, we disrupt this abnormal signaling pathway that drives CML [chronic myeloid leukemia] cell proliferation and survival, ultimately leading to decreased cancer cell growth, increased apoptosis or cell death, and potentially inducing a disease remission,” Samantha Maples, PharmD, BCOP, clinical pharmacy specialist supervisor for hematology and cellular therapy at Allegheny Health Network in Pittsburgh, PA, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about the BCR-ABL1 inhibitor drug class.   Music Credit: “Fireflies and Stardust” by Kevin MacLeod  Licensed under Creative Commons by Attribution 3.0   Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by September 5, 2026. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.  Learning outcome: Learner will report an increase in knowledge related to the use of BCR-ABL1 inhibitors in the treatment of CML. Episode Notes   Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Pharmacology 101 series Episode 322: Nursing Strategies to Reduce Readmission Rates for Patients With Cancer Episode 215: Navigate Updates in Oral Adherence to Cancer Therapies ONS Voice articles: Adherence to Oral Anticancer Medication Combination Therapy Shows Promise for Chronic Myeloid Leukemia The Case of the Medication Modification The Case of the Safety Session ONS course: Safe Handling Basics Clinical Journal of Oncology Nursing articles: Targeted Drug Therapies: Beyond Blood Counts and Chemistries Oncology Nursing Forum articles: Adherence and Coping Strategies in Outpatients With Chronic Myeloid Leukemia Receiving Oral Tyrosine Kinase Inhibitors Fear of Progression in Outpatients With Chronic Myeloid Leukemia on Oral Tyrosine Kinase Inhibitors Other ONS resources: Biomarker Database Financial Toxicity Huddle Card Tyrosine Kinase Inhibitors Huddle Card Oral Anticancer Medication Care Compass: Resources for Interprofessional Navigation Oral Anticancer Medication Learning Library National Comprehensive Cancer Network National Comprehensive Cancer Network patient resources To discuss the information in this episode with other oncology nurses, visit the ONS Communities.   To find resources for creating an ONS Podcast club in your chapter or nursing community, visit the ONS Podcast Library.  To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode  “The IRIS study led to the approval of the BCR-ABL1 and TKI, imatinib, for CML in 2001 and completely changed the landscape of CML treatment. Then came the second-generation BCR-ABL1 TKIs: dasatinib in 2006, quickly followed by nilotinib in 2007. Thereafter came our second-generation, bosutinib, and our first approved third-generation TKI, ponatinib, both in 2012, which was a huge milestone as ponatinib overcomes resistance to the T315 I mutation, which no previously approved TKIs worked against.” TS 2:16 “The newest approved TKI, asciminib, is an allosteric inhibitor that binds to a different pocket on the BCR-ABL kinase via allosteric binding to the ABL myristoyl pocket. It's what's called a STAMP inhibitor, where STAMP stands for ‘specifically targeting the ABL myristoyl pocket.' And while all the TKIs target the BCR-ABL1 binding site, they can also inhibit different off-target kinases. And these differences in off-target inhibition are responsible for some of the different toxicities we see among the TKIs.” TS 4:51 “As a class, common toxicities include nausea; vomiting; diarrhea; cardiac toxicities, including cardiac arrhythmias and congestive heart failure; metabolic abnormalities such as hypercholesterolemia and hypertriglyceridemia; nephrotoxicity; hepatic toxicity; hemorrhaging and bleeding; as well as cytopenia. Individually, some of these agents are more likely to cause certain side effects compared to others, and there are unique toxicities associated with certain TKIs.” TS 8:10 “We've moved to using preemptive loperamide [in our clinic] for the first three days of starting treatment, because it's really hard to get patients to continue to take a medication if they have such severe diarrhea that they end up in the hospital or they're unable to leave their house. A lot of times, we will proactively give patients antiemetics and loperamide to help with the nausea, vomiting, and diarrhea. And then we can back off to an as-needed basis once they've been established on treatment. We can also use medications to help manage long-term complications that can require supportive care, such as statin therapy for high cholesterol, levothyroxine for hypothyroidism, anticoagulants for any venous thromboembolism, and antihypertensive medications for managing any new or worsening high blood pressure.” TS 12:44 “We are continually seeing these agents expand their indications to different lines of therapy, as well as more TKIs being approved for acute lymphoblastic leukemia. For example, asciminib just got approved in the frontline setting within the last year, whereas previously it was only approved in relapsed refractory setting. Last year, imatinib was the first BCR-ABL1 TKI to come out with a commercially supplied suspension option as well, which is huge in the pediatric space and [for] our adult patients who are unable to swallow tablets for other clinical reasons.” TS 21:22 “There is more information being published on the safe discontinuation of these medications with treatment-free remissions, and more information is coming out about who would be eligible and who can have the option to stop these treatments instead of having a lifelong chronic condition requiring continuous treatment. We're seeing more patients in clinical practice be able to stop BCR-ABL1 treatment, which has been a great development in CML.” TS 25:29

Welcome back to the Oncology Brothers podcast! In this episode, Drs. Rohit & Rahul Gosain are joined by Dr. Joshua Sabari from the NYU Langone Cancer Center to discuss the exciting recent approval of Zongertinib, the first oral TKI for HER2-positive lung cancer. We dived deep into the prevalence of HER2 mutations in non-small cell lung cancer, the study design and findings from the Beamion LUNG-1 trial, and the implications of this new therapy in clinical practice. Dr. Sabari shared insights on the efficacy of Zongertinib, including impressive response rates and progression-free survival data, as well as its side effect profile compared to other treatments like trastuzumab deruxtecan (T-DXd). Key topics covered in this episode: •⁠  ⁠Overview of HER2 mutations in lung cancer •⁠  ⁠Study design and results of the Beamion LUNG-1 •⁠  ⁠Comparison of Zongertinib and T-DXd in treatment settings •⁠  ⁠Management of common side effects associated with Zongertinib •⁠  ⁠Future directions for HER2-targeted therapies Join us for this informative discussion as we explore the latest advancements in lung cancer treatment and what they mean for patients and clinicians alike. Don't forget to subscribe for more episodes on new approvals, side effect management, and practice-changing data in oncology! Follow us on social media: •⁠  ⁠X/Twitter: https://twitter.com/oncbrothers •⁠  ⁠Instagram: https://www.instagram.com/oncbrothers •⁠  Website: https://oncbrothers.com/

A panel of hematology leaders discusses the latest in ALL and T-cell ALL therapy, including TKI+blina combinations, venetoclax strategies, and the emerging role of CD7 CAR T-cell therapies in reshaping treatment paradigms.

A new ERBB2 (HER2) targeting TKI is approved for NSCLC. We review the characteristics of the drug and summarize the current landscape in treating HER-mutated advanced NSCLC.