Podcasts about geographic

Dr. Bobbi S. Pritt joins Tick Boot Camp Podcast for a scientific deep dive into Lyme disease diagnostics, co-infections, and emerging tick-borne pathogens. Dr. Pritt is Professor and Chair of Laboratory Medicine and Pathology at Mayo Clinic and Director of the Clinical Parasitology Laboratory in Rochester, Minnesota. An internationally recognized expert in vector-borne diseases, she is globally known for discovering new tick-borne pathogens—including Borrelia mayonii and Ehrlichia muris eauclairensis—and for advancing cutting-edge molecular and metagenomic diagnostic testing used nationwide. This episode offers essential clarity for anyone navigating Lyme disease, unexplained symptoms, or confusing test results. Dr. Pritt explains why standard tests often miss early Lyme, how PCR and molecular tools can detect active infection, and what metagenomic sequencing may offer for more accurate and comprehensive diagnostics in the future. Episode Summary Dr. Pritt breaks down how Lyme and other tick-borne diseases are detected through antibody testing, PCR, tissue analysis, and cutting-edge molecular methods. She explains how her lab discovered multiple new pathogens in the upper Midwest, the role of tick species in disease transmission, and why co-infections complicate diagnosis. This conversation also explores geographic spread, climate change, tick behavior, and the strengths and limitations of today's test algorithms. Key Topics • Discovery of Borrelia mayonii as a second cause of Lyme disease in the U.S. • Identification and characterization of Ehrlichia muris eauclairensis • Geographic hotspots and why the upper Midwest produces unique pathogens • Tick species differences: blacklegged vs. lone star ticks and their hunting strategies • Co-feeding in ticks and its role in pathogen evolution • Why early Lyme tests often return false-negative results • The science behind false positives and cross-reactivity • PCR advantages and limitations for detecting Borrelia • When skin biopsies can outperform blood tests • Differentiating Lyme, B. miyamotoi, Anaplasma, Babesia, and Powassan virus • When clinicians should order a full tick-borne disease panel • How climate and ecological changes drive new tick-borne threats • The promise of metagenomics and immune-signature diagnostics What You'll Learn • Why current Lyme testing algorithms struggle in early infection • How new tick-borne pathogens are discovered and validated • Why lone star ticks are more aggressive and changing regional risk • When and why molecular testing is more effective • What symptoms point to co-infections needing additional testing • Why doxycycline is not effective for certain pathogens like Babesia • How metagenomic sequencing could identify every pathogen in a single sample • Where diagnostic innovation is heading and what patients can expect

My guest today is David Sutcliffe, a somatic psychotherapist and former actor who has stepped off the red carpets of Hollywood to venture into the deeper landscapes of the masculine soul.David is something of an enigma to me. He's a therapist who champions the necessity of men getting in touch with their feelings and expressing their rage and grief. Yet, he is also an ardent Trump supporter and has interviewed uber-masculine figures like Andrew Tate.In this conversation, we certainly don't align on everything, but we remain willing to lean in and see what the friction reveals.It's worth saying: this conversation was recorded in September 2025, before the wake of the Epstein files released December 2025. This would have come up in our conversation if we had recorded this afterwards.A little more about David. For years, he was an archetypal “cute guy” or “bad boyfriend” on television - but behind the scenes he eventually found himself on his own road of ashes - where the trappings of fame and success turned to dust, inviting him into a more rigorous descent.Together, we explore the cost of the “nice guy” mask and the disorientation of a fatherless upbringing. We speak of the “devouring mother,” the search for authentic masculine role models, and his own views on “masculine leadership” and traditional gender roles.And finally, David reminds us that maturity demands the courage to face or darkness, tame the flames of our inner dragon, and take up the seat of our own sovereignty.A brief aside: for men who wish to work with me, you're invited to my upcoming immersion & online cohorts:* Awakening the Wild Erotic, Vancouver Island (April 24-26)* The Deep Masculine, Online (next cohort begins May 3)As well, don't miss the inaugural Cascadia Men's Conference, happening just north of Vancouver Aug 6-9th, 2026.For those drawn to David's style and offerings, check out the links below:SHOW LINKS* David Sutcliffe School for Kings* David Sutcliffe on IG * Poem - How to Tame A DragonSHOW NOTESHere are the show note highlights with the updated timecode format, tightened for impact:* 03:55 — The Geographic and Spiritual Check-in: David shares his current life in Mexico and how his relationship with God has become the anchor point of his life and marriage.* 05:40 — The Interviewer's Tightrope: Reflecting on David's interviews with polarizing figures like Andrew Tate and the “art of the interview” when navigating high-defense mechanisms.* 07:18 — From the Red Carpet to the Road of Ashes: David recounts his twenty-year acting career and the mid-life collapse that led him to trade Hollywood fame for the rigors of somatic healing.* 09:51 — The Alchemy of the Mat: An exploration of Core Energetics and the necessity of physical expression—hitting, kicking, and shouting—to move repressed “sob and rage.”* 13:10 — The Missing Father and the Devouring Mother: Discussing the psychic consequences of an absent father and how the resulting “devouring mother” energy can lead men to self-abandonment.* 26:45 — The War of the Sexes: A look at the “bitterness and vitriol” in modern gender relations and the cultural propaganda of the “bumbling father” in media.* 28:26 — Feminism and the Manosphere: David offers his take on how radicalized social movements can lead to a reactive “manosphere” and the collective struggle to truly see one another.* 39:15 — The Politics of Polarity: David addresses his shift from Hollywood progressive to a supporter of traditional values and Donald Trump, framing it as a return to “reality.”* 53:12 — The Strongman Archetype: Exploring the qualities of figures like Trump and Tate, and why men are gravitating toward “strongmen” in a landscape of cultural chaos.* 1:11:15 — Taming the Inner Dragon: A concluding reminder that our inner shadows are not to be slain, but looked in the eye until they recognize their master. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit themythicmasculine.substack.com/subscribe

The CRE transaction market posted its first annual property count increase since 2021, industrial dollar volume surged 54%, and office may finally be finding a floor. In this episode of CRE Exchange, hosts Omar Eltorai and Cole Perry break down Q4 and full-year 2025 transaction data, pricing trends across major sectors and MSAs, and what the numbers say about where the market is heading. Featuring a special conversation with Phil Tily, Alex Jaffe, and Mike Amthor from Altus Group's advisory practice on valuation and performance trends across the ODCE Index. Key moments01:28 Key stat of the day and macro backdrop05:50 Q4 and full year transactions09:12 Velocity and pricing trends12:36 Subsector and deal size comparisons14:13 Geographic winners and losers19:15 Biggest surprises in 202521:48 Sector shockers: retail, industrial, office27:21 ODCE data and Q4 returns31:46 Apartments trends and outlook35:20 Industrial markets and SoCal repricing40:56 Office stabilization and green Shoots46:58 Retail resilience and mark-to-market Resources mentionedPhil Tily: https://www.linkedin.com/in/phil-tily-7b9a9027/Mike Amthor: https://www.linkedin.com/in/michael-amthor-40865154/Alex Jaffe: https://www.linkedin.com/in/alexander-jaffe-mai-31425123/Q4 2025 US CRE Investment and Transactions quarterly report: https://www.altusgroup.com/featured-insights/cre-transactions/Altus' Q4 valuation and performance trends analysis of the NCREIF ODCE Index: https://www.altusgroup.com/webinars/ncreif-odce-index-quarterly-analysis/#featuredEmail us: altusresearch@altusgroup.com

Thanks to our Partners, NAPA Auto Care and NAPA TRACS Watch Full Video Episode In this episode, Carm Capriotto speaks with Tom Ham about the rising labor rates shaping the automotive repair industry. Drawing from the Labor Rate Tracker tool on the Automotive Management Network, Tom explains how shops across the country are steadily increasing rates, with many approaching the $200 per hour threshold. Geographic trends reveal higher rates in regions like the San Francisco Bay Area and Connecticut, and Tom recommends gradual monthly increases of $1 to $2 to maintain profitability without alarming customers. They also discuss shifting business realities, including rising repair order values driven by vehicle complexity, higher parts costs, and increased technician compensation, even as car counts may level off. Many shops are also setting vehicle age limits to improve efficiency and reduce liability. Looking ahead, Tom highlights how artificial intelligence will enhance diagnostics and workflow, supporting the rise of a highly skilled mechanical specialist working alongside AI. The episode offers a forward looking view of an industry evolving through smarter pricing, cultural alignment, and advanced technology. https://laborratetracker.com/ Timestamps (00:00:00) Introduction & Industry Updates (00:02:30) Tom Ham discusses the "Labor Rate Tracker" and how shops are breaking through psychological pricing barriers as they approach $200 per hour. (00:05:00) Geographic Heat Maps: A breakdown of where rates are highest (Bay Area, Connecticut) and lowest (Midwest, South), and the use of heat maps to visualize the data. (00:08:15) The Incremental Increase Strategy: Tom advises shop owners on how to raise labor rates by small amounts (1–2) to overcome the fear of price adjustments. (00:10:45) Rates by Shop & Vehicle Type: Analysis of which shops command the highest rates (RVs, Diesels) versus the lowest (Collision, Tire Stores), and vehicle makes (Euro vs....

In this episode of The Distribution, Brandon Sedloff sits down with Katie Fasken, founder of August Advisors, to unpack the overlooked depth of Canadian institutional capital. Drawing on her experience building institutional relationships at Slate Asset Management and launching her own boutique placement firm, Katie explains why Canada is far more than just the “Maple Eight” pensions. She breaks down the size of the broader market, the nuances of fundraising across provinces, and what it really takes for global GPs to succeed with Canadian LPs. The conversation spans real estate, private equity, infrastructure, continuation vehicles, and the emerging private wealth channel, offering a tactical look at capital formation north of the border. They discuss: Why Canada's pension market is closer to 4 trillion in assets and where the opportunity lies beyond the Maple Eight What mid-sized Canadian pension funds look for in lower mid-market private equity and real estate managers Infrastructure's rise in allocation and how LPs are redefining what qualifies as infrastructure Geographic shifts toward Europe and how Canadian investors are thinking about US exposure amid political uncertainty The growing role of continuation vehicles and liquidity solutions in private equity portfolios The realities of tapping the Canadian wealth channel and why platform access can take years Links: Katie on LinkedIn - https://www.linkedin.com/in/katie-fasken-8b433a12/ August Advisors - https://www.augustadvisors.ca/ Brandon on LinkedIn - ⁠https://www.linkedin.com/in/bsedloff/⁠ Juniper Square - ⁠https://www.junipersquare.com/⁠ Topics: (00:00:00) - Intro (00:02:07) - Katie's career and background (00:07:26) - Launching August Advisors (00:09:32) - Beyond the maple eight to 4T in pension assets (00:12:38) - Why GPs miss Canada + what's driving allocations (00:18:56) - Real assets pulse (00:21:55) - Private equity trends (00:23:51) - Defining ‘infrastructure' in 2026 (00:25:14) - US vs Europe allocations, politics, and fiduciary reality (00:28:31) - Canada's information gap (00:29:30) - August's playbook (00:33:37) - Operating rhythm (00:36:05) - The Canadian wealth channel (00:41:35) - Portfolio rebalancing: real estate vs infrastructure vs lower mid-market PE (00:43:36) - Final takeaways + how to reach August Advisors

In this episode, Jamie and Roope cover: Roope's background: Northern Finland, starting goalie at 4, full-time by 9 Why he started coaching while still playing: “I didn't get the help, so I wanted to help others” How Finland's goalie coaching education system works (levels, regional coaches, consistent messaging) The shift in Finnish coaching culture: more organized education and easier pathways into coaching Building a goalie development program from scratch at Kärpät: More resources + more ice time (4–5 goalie touches per week, not 1) Recruiting coaches and building a culture that values goalie development How Roope made the jump to North America and the Red Wings organization What Roope looks for in a new AHL/NHL prospect: strengths first, weaknesses second The non-negotiable skill: skating pace and sharpness (on feet + on knees) Can you turn a bad skater into an elite skater? His honest take Geographic goalie “identities”: Finland hands, Czech athleticism, Russian body control, North American compete AHL → NHL readiness: sustainable habits, success at each level, details that scale to 60+ games Why some goalies stick: passing the “eye test” + coach trust RVH teaching priorities: stay on feet longer, strong anchor, learn to recover to feet How AHL consistency is built: coach consistency, structured routines, monthly check-ins, and small drill evolutions ECHL as a development tool: not required, but often valuable for hunger and growth Roope's parting shot: continuing education and staying hungry to improve every day Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In our latest episode, we discuss the results of the PRIMA retinal implant in treating eyes with center involved geographic atrophy as presented in a recent New England Journal of Medicine article. 85% of eyes had meaningful improvement in vision at one year with Dr. Daniel Palanker, Professor of Ophthalmology and Electrical Engineering, Stanford University.

Long before skyscrapers defined the skyline, New York's destiny was shaped by its harbor, rivers, and a bold vision for growth. Historian Justin Rivers joins Anna Melo and NYSE archivist Dave D'Onofrio Inside the ICE House to trace how geography, trade, and revolution transformed a Dutch outpost into the foundation of modern finance. From the defensive wall that gave Wall Street its name to the sweeping 1811 grid plan that organized Manhattan's expansion, they explore the pivotal decisions that structured the city's rise.

In this live episode recorded at the AHR Expo 2026 Podcast Pavilion in Las Vegas, host Bryan sits down with longtime friend and industry expert Nikki Krueger of Santa Fe and AprilAire. Nikki brings over 15 years of experience in indoor air quality and whole-home dehumidification to the conversation, having started her career with AprilAire before moving to Santa Fe (formerly Ultra Aire) — and now coming full circle as the two brands have integrated under the AprilAire umbrella as of January 1st of this year. The episode dives deep into a topic close to both hosts' hearts: how to properly manage indoor humidity, and what role a whole-home ventilating dehumidifier plays in a comprehensive HVAC system strategy. Bryan and Nikki lay out a holistic framework for tackling moisture problems, emphasizing that a dehumidifier should be the last tool added — not the first. Before reaching for dedicated dehumidification equipment, contractors need to assess the building envelope for air leaks, evaluate whether the air conditioning system is properly sized (oversizing is a major contributor to poor latent removal), confirm that the AC is set up with the right airflow and sensible heat ratio, and take into account the ventilation strategy and occupant behavior. The pair discuss real-world scenarios ranging from elderly residents in Florida who keep their thermostats at 80°F, to a project in Barbados where overcooling caused interstitial condensation in walls and ceilings. The message is clear: humidity control is a systems problem, not a single-product fix. A significant portion of the episode is dedicated to proper installation practices for whole-home dehumidifiers. Nikki explains why Santa Fe recommends pulling from a dedicated return and discharging into the supply side of the AC duct — rather than tying into the return side — because the heat generated by dehumidification (roughly 1,054 BTUs per pint of water removed) can warm the AC evaporator coil and reduce its latent removal capacity. Bryan adds nuance around dew point management when routing outdoor air ducts, and both hosts agree that fan operation strategy (continuous low-speed vs. intermittent) matters more in tight, low-load homes where mixing is harder to achieve naturally. They also clarify a common misconception: a ventilating dehumidifier is not a dedicated outdoor air system (DOAS) and does not automatically condition incoming ventilation air before it enters the home. The conversation wraps up with an exciting look at Santa Fe's newly launched Ultra V Series, which features an upgraded 8-inch ventilation duct (up from 6 inches), a more powerful fan for handling higher static pressure in retrofit applications, a new digital control panel, and a wired remote humidity sensor that can be placed in the living space for more accurate readings. Nikki and Bryan also field audience questions on topics like short-cycling risks from oversized dehumidifiers and why Santa Fe chose a wired sensor over wireless (accuracy, reliability, and fewer callback headaches). Bryan closes by noting that rising dew points across most U.S. markets over the last 20 years make whole-home dehumidification more relevant than ever — and that any region where you can see green grass outside is a candidate for a more advanced moisture control strategy. Topics Covered Introduction to Nikki Krueger and the merger of Santa Fe and AprilAire under one brand The purpose of whole-home ventilating dehumidifiers and how they fit into an overall HVAC system strategy Latent vs. sensible heat loads explained — and why both matter for comfort and moisture control Geographic reach of humidity problems — why dehumidification isn't just a Florida or Gulf Coast issue Ken Gehring ("Teddy Bear"), inventor of the whole-house ventilating dehumidifier, and his framework for diagnosing moisture problems The four-factor checklist before deploying a dehumidifier: building envelope, AC sizing, AC setup/airflow, and ventilation strategy How occupant behavior (thermostat preferences, activity levels, large households) creates latent load variability The dangers of overcooling — how setting thermostat too low can cause interstitial condensation in walls, ceilings, and attics Sensible heat ratio (SHR) and its role in a system's ability to remove moisture — targeting ~350 CFM per ton in humid climates Why dehumidifiers should connect to a dedicated return and discharge into the supply — not tie into the AC return side How dehumidifier heat output (~1,054 BTUs per pint) can reduce AC coil efficiency when ducted incorrectly Fan-on strategy debate: when running continuous low-speed circulation helps vs. hurts humidity control Tighter homes, smaller systems, and the importance of air mixing strategies (including ceiling fans)  Ventilating dehumidifiers vs. dedicated outdoor air systems (DOAS) — clearing up a common misconception about how ventilation air is conditioned Dew point management for outdoor air ducts — preventing condensation inside duct runs Using dehumidifiers to address sweating ductwork in multi-story homes Rising dew points over the past 20 years and what "green grass climates" means for dehumidification demand Heat pump oversizing challenges in colder climates and the downstream impact on AC latent removal Santa Fe's new Ultra V Series: 8-inch ventilation duct, stronger fan, digital controls, and wired remote humidity sensor Why proper dehumidifier sizing matters: short-cycling risks, moisture reservoir release, and uneven RH throughout the home Why Santa Fe chose a wired humidity sensor — accuracy, reliability, and reducing contractor callbacks Audience Q&A: oversizing consequences, short-cycling mechanics, and sensor placement best practices   Learn more about Santa Fe Dehumidifiers at santafeproducts.com.  Connect with Nikki Krueger on LinkedIn or Instagram @nikkikruegerIAQ. Check out the work of Ken Gehring ("Teddy Bear") or ask him a question on the HVAC Talk Forum: hvac-talk.com. Have a question that you want us to answer on the podcast? Submit your questions at https://www.speakpipe.com/hvacschool. Purchase your tickets or learn more about the 7th Annual HVACR Training Symposium at https://hvacrschool.com/symposium. Subscribe to our podcast on your iPhone or Android. Subscribe to our YouTube channel. Check out our handy calculators here or on the HVAC School Mobile App for Apple and Android.

Welcome back to a brand-new series of the Building Better Cultures Podcast! In the first episode of the season, host Scott McInnes is joined by Phil Codd, Managing Director of Expleo in Ireland. They discuss the multifaceted nature of organisational culture, emphasising the importance of aligning leadership and employee cultures. Phil shares insights on employee happiness, effective communication, and the significance of feedback loops in fostering a positive work environment. The conversation also touches on the challenges of hybrid work, the future of organisational culture, and the need for organisations to adapt to a more flexible and inclusive work environments.   Here are some of the key insights from the episode: ·      Culture isn't just one thing; organisations have multiple cultures. ·      Happy employees lead to happy customers and growth. ·      Effective communication is a critical leadership skill. ·      Feedback loops are essential for employee engagement. ·      Celebrating employee longevity can enhance morale. ·      Technology can facilitate continuous feedback in organisations. ·      Hybrid work requires new ways of connecting teams. ·      Organisational culture is not confined to physical spaces. ·      Aligning leadership culture with employee culture is vital. ·      Policies should focus on the human aspects of work. Chapters: 00:00 Introduction to Building Better Cultures Podcast 03:12 Understanding Organisational Culture 09:54 The Importance of Communication in Culture 12:30 Feedback Loops and Employee Engagement 17:29 Flexibility and Hybrid Working Models 23:51 Challenges of Geographic and Hybrid Work 28:58 Future of Work and Cultural Alignment Keywords: Organisational culture, leadership, employee engagement, communication, feedback loops, hybrid work, employee happiness, culture alignment, workplace dynamics, future of work Connect with us: LinkedIn YouTube Instagram

In this talk, I share how choreography plays a big role in content creation and the type of audience that you attract. CONQUER SHYNESS

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JHLT: The Podcast returns with an episode  for our heart transplant colleagues, discussing the paper, "Barriers and opportunities in donation after circulatory death heart transplantation," from the February issue of JHLT. Featured on this episode is first author, Katherine G. Phillips, MD, of the Department of Cardiothoracic Surgery at NYU Langone, and co-author, Brian Wayda, MD, from the Division of Cardiology at NYU Langone. The discussion explores: Geographic variability on DCD heart utilization—why it happens and how to address Concerns around donor progression to circulatory arrest after life support withdrawal The volume of DCD hearts not utilized each year—and the gap between those successfully transplanted For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Navy tracks objects moving 200+ knots underwater at impossible depths. USO database reveals centuries of submerged UFO encounters.This week's Fringe News Briefing covers four major stories: A groundbreaking study found 944 cases where Bigfoot and UFO sightings occurred within 72 hours of each other. Skinwalker Ranch Season 6 documented invisible phenomena, mysterious 1.6 gigahertz signals, and heat-resistant ceramic buried underground. A former Bank of England analyst publicly urged the institution to prepare for financial collapse in the event of alien disclosure. And new research suggests human consciousness arises from the brain resonating with the quantum vacuum's zero-point field.Then we dive deep into Unidentified Submerged Objects. Commander David Fravor's famous 2004 Nimitz encounter wasn't just about the Tic Tac in the air—USS Princeton tracked objects underwater for two weeks before that encounter. Objects dropping from 80,000 feet to sea level in less than a second, continuing into the ocean without any change in momentum. The Enigma database documents centuries of these encounters, from medieval chronicles to modern military sonar data. Objects moving at 200+ knots underwater, diving to 27,000 feet, transitioning between water and air with no splash or disturbance. Geographic hotspots near the Puerto Rico Trench, the Pacific Northwest, and the Gulf of Mexico show consistent activity. If the U.S. Navy has decades of classified USO data, and if these objects exhibit the same physics-defying capabilities as aerial UAPs, we need to talk about what that actually means for humanity's understanding of what's operating in Earth's oceans.

The Institute of Internal Auditors Presents: All Things Internal Audit    In this episode, Adam Ross is joined by Filipe Ribeiro and Julien Perreault to discuss how supply chain risk has evolved into an interconnected, enterprisewide challenge. They discuss where organizations underestimate exposure, how risks quietly accumulate across the value chain, and why internal audit is uniquely positioned to identify blind spots before disruptions escalate. The conversation spans real-world examples from agriculture and highly regulated industries, third-party risk, continuous monitoring, and the growing impact of automation and AI on supply chains.   HOST: Adam Ross, CIA, CISA Partner, Grant Thornton Advisors LLC GUEST: Filipe Ribeiro, CIA, CRMA, CFE Group Internal Audit Manager, Aldar Julien Perreault, CPIM, MBA Experienced Manager, Sourcing and Supply Chain Advisory, Grant Thornton Advisors LLC   KEY POINTS: Introduction to Modern Supply Chain Risk [00:00:02–00:01:22] From Operational Inconvenience to Strategic Risk [00:01:22–00:02:24] Why Supply Chain Risk Is Now Systemic and Enterprisewide [00:02:32–00:03:11] Where Organizations Commonly Underestimate Exposure [00:03:22–00:04:33] When "Green Dashboards" Mask Emerging Risk [00:03:33–00:05:08] How Informal Workarounds Quietly Accumulate Enterprise Risk [00:05:08–00:05:47] Agricultural Case Study: How Small Upstream Delays Become Major Downstream Failures [00:05:53–00:07:52] Using Continuous Monitoring to Detect Hidden Timing and Dependency Risks [00:07:57–00:12:26] Supply Chain Risk in Remote, Capital-Intensive, and Highly Regulated Environments [00:12:54–00:15:25] Balancing Regulatory Compliance and Operational Efficiency [00:15:42–00:18:55] Procure-to-Pay Risk and the Rise of Operational "Noise" [00:19:14–00:21:01] When Exceptions Become the Normal Operating Model [00:21:01–00:23:15] Third-Party Risk as a Business Resilience Issue [00:25:15–00:27:12] Governance, Speed of Business, and Supplier Ecosystems [00:27:12–00:30:25] Managing Supplier Concentration Risk Without Sacrificing Resilience [00:31:20–00:35:04] Geographic and Cultural Complexity as an Underestimated Risk Driver [00:35:36–00:37:27] How Internal Audit Can Add Value Without Compromising Independence [00:38:35–00:41:29] Emerging Risks: Automation, AI, Data Quality, and Governance Lag [00:41:47–00:46:18] Final Thoughts on the Future of Supply Chain Risk [00:46:29–00:47:05]   Visit The IIA's website or YouTube channel for related topics and more.   IIA RELATED CONTENT:  Interested in this topic? Visit the links below for more resources: Global Internal Audit Standards Third-Party Topical Requirement Continuous Auditing and Monitoring, 3rd Edition Boardroom: Breaks in the Chain GAM 2026   Follow All Things Internal Audit: Apple Podcasts Spotify Libsyn Deezer

Today, I'm joined by Sam Browne, CEO and co-founder of Let's Do This.   A platform for mass-participation sports events, Let's Do This partners with marathons, triathlons, and cycling events to help people discover life-changing athletic experiences.   In this episode, we discuss building tech to get people together offline.   We also cover:   The company's mission to create shared experiences Current problems with the experience economy Expanding to 18 international markets Subscribe to the podcast → insider.fitt.co/podcast  Subscribe to our newsletter → insider.fitt.co/subscribe   Follow us on LinkedIn → linkedin.com/company/fittinsider    Website: www.letsdothis.com  Let's Do This on Instagram: https://www.instagram.com/letsdothis.com_/?hl=en  Sam's LinkedIn: https://www.linkedin.com/in/sam-browne-a86268b0/   The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart fitness ecosystem for fitness and health facilities. Fitt Talent: https://talent.fitt.co/  Consulting: https://consulting.fitt.co/  Investments: https://capital.fitt.co/    Chapters: (00:00) Introduction (01:03) Background and mission (02:13) Offline connection (02:41) Origin story (04:30) Identifying market gap (05:23) Discovery, technology, and payments problems (06:45) Layering growth S-curves (09:00) The ultimate growth channel (11:30) The supply side (13:45) Technology infrastructure (16:00) COVID impact (18:30) Post-pandemic surge (21:00) Isolated, distracted, or connected (23:15) Why experiences beat things (25:30) Bringing people together (27:00) The choice (29:08) Expansion strategy (30:15) Geographic rollout (31:15) Future verticals (32:00) Supply problems (33:09) Lifetime partnerships (34:18) Serving event organizers (34:48) Where to discover your next challenge (35:32) Conclusion    

In this episode of Econ 102, Noah and Erik are joined by Flock Safety CEO to cover America's crime crisis and how to solve it with technology. They explore international comparisons, why America's crime problem is unique, how cameras can deter crime, tradeoffs in crime reduction, and more.-Sponsors:NotionAI meeting notes lives right in Notion, everything you capture, whether that's meetings, podcasts, interviews, conversations, live exactly where you plan, build, and get things done.  Here's an exclusive offer for our listeners. Try one month for free at ⁠https://www.notion.com/lp/econ102 NetSuiteMore than 42,000 businesses have already upgraded to NetSuite by Oracle, the #1 cloud financial system bringing accounting, financial management, inventory, HR, into ONE proven platform. Download the CFO's Guide to AI and Machine learning: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://netsuite.com/102 Found Found provides small business owners tools to track expenses, calculate taxes, manage cashflow, send invoices and more. Open a Found account for free at https://found.com-FOLLOW on X:https://x.com/glangleyhttps://x.com/eriktorenberghttps://x.com/Noahpinion-Shownotes brought to you by Notion AI Meeting Notes - try one month for free at https://www.notion.com/lp/econ102- Discussion opened with comparisons between AI's impact on various professions, particularly radiology- America's murder rate is approximately 5x higher than Europe and 10x higher than Asia, making it a significantly more violent country- Crime has become increasingly sophisticated over the past decade, shifting from impulsive juvenile offenses to organized, profit-driven enterprises- Foreign criminal organizations operate with different specialties: South American gangs focus on narcotics, firearms, and use drones for reconnaissance- Geographic spread: American cities are too suburban for effective foot patrols, forcing police to drive instead - foot patrols are proven to be more effective deterrents- Gun availability: While firearms make approximately a 2x difference in murder rates, eliminating all guns (which would be extremely difficult) would only get America halfway to European safety levels- Americans have restructured their entire lives around crime avoidance, creating costs not captured in crime statistics- Deterrence through likelihood of capture: Research shows criminals are deterred by the likelihood of getting caught, not by severity of punishment- Garrett compared criminal behavior to children - they commit crimes because they think they'll get away with it, not because punishment is insufficient- Cameras create permanent records that make crime detection highly likely, fundamentally changing the risk calculus- Even with permissive DAs or judges, the existence of video evidence creates accountability- Japan achieved approximately a 5x reduction in crime through widespread camera deployment- Cameras effectively ended many categories of street crime, with criminals openly acknowledging they "can't commit crimes, there's cameras everywhere"- Reduced crime would save cities enormous costs - San Francisco could save approximately $1 billion by reducing crime to Asian standards- Noah emphasized that "law and order" rhetoric won't work in liberal cities - need a different framing- The progressive case for surveillance: Enables walkable neighborhoods and vibrant urbanism- Some American cities don't believe crime is a serious problem, viewing current levels as acceptable- These cities will likely experience declining populations and tax bases, creating a downward spiral until they recognize the need for action- Cities that resist camera technology often have underlying trust issues with their local government- In communities where residents trust their elected officials want them to succeed, camera adoption is widely embraced-Timestamps:0:00 - Introduction3:00 - The State of Crime in America6:04 - Crime Statistics Debate10:59 - The Solution: Cameras Everywhere12:15 - Sponsors: Notion | NetSuite17:00 - How Deterrence Really Works19:35 - Japan's Success with Cameras22:46 - Privacy and Cultural Trade-offs25:50 - Sponsor: Found38:35 - Economic Benefits and Policy44:19 - Closing Thoughts-Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details, please see https://a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this unflinching episode of the Crux True Survival Story Podcast, hosts Kaycee McIntosh and Julie Henningsen delve into one of history's most harrowing survival stories. On October 13, 1972, Uruguayan Air Force Flight 571 slammed into the Andes Mountains, leaving 33 survivors stranded at 12,000 feet in subzero temperatures. For 72 days, they battled avalanches, frostbite, and starvation. When their meager supplies ran out, they faced an unthinkable decision: consume the dead or die themselves. This episode chronicles the psychological torment, the impossible moral choices, and the superhuman trek of two survivors who walked ten days through the frozen mountains to find rescue. A raw testament to human resilience and the terrifying price of survival. 00:00 Welcome and Housekeeping 01:25 Introducing the Podcast 01:48 Setting the Scene: The Andes Flight Disaster 02:08 The Crash 03:11 Immediate Aftermath 04:05 Struggle for Survival 15:55 The Search is Called Off 18:16 Facing the Unthinkable 20:06 The Grim Reality of Survival 21:01 A Desperate Decision 23:35 The Psychological Toll 25:44 Avalanche Strikes Again 27:18 A Daring Escape Plan 28:38 Journey Through the Mountains 35:36 Rescue and Aftermath 39:22 Legacy of Survival Email us! thecruxsurvival@gmail.com Instagram https://www.instagram.com/thecruxpodcast/ Get schooled by Julie in outdoor wilderness medicine! https://www.headwatersfieldmedicine.com/ Check out our website! www.thecruxsurvival.com REFERENCES Primary Sources: Alive: The Story of the Andes Survivors by Piers Paul Read (1974) Miracle in the Andes: 72 Days on the Mountain and My Long Trek Home by Nando Parrado (2006) Out of the Silence: After the Crash by Eduardo Strauch (2019) Technical Documentation: Official Uruguayan Air Force Flight 571 accident investigation reports Medical journals documenting survivors' conditions upon rescue Geographic surveys of crash site location Aviation records and flight data Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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In this episode, we discuss Chris's career transition from custom construction to financial services, the business opportunity in financial literacy education, and how families can build generational wealth through proper licensing and planning. Key Topics Discussed Chris's Career Journey 20+ years as a custom builder and general contractor in Toronto Notable projects: National Ballet, Casa Loma, Ontario Art Gallery, Casino Rama, luxury homes in Bridal Path and Forest Hill Challenges of relocating construction business from Ontario to BC The decision to transition careers at 45 years old The Career Transition Moving from construction to financial services Getting licensed through Insurance Council of British Columbia Completing provincial-level exams at Okanagan College The intimidation and pressure of returning to formal education in mid-40s The Business Opportunity Three pathways: personal finance management, one-on-one client consulting, or building a team/agency Teaching financial literacy to Canadian families Flexibility to work from home and control your own schedule Ability to pass business to family members (spouse, children) - keeping it as generational wealth Why This Matters Now Rising cost of living outpacing wage increases Mortgage rates doubling for many families Need for additional income streams Opportunity to learn financial literacy while earning The Licensing Process Provincial-level certification through Insurance Council of British Columbia Post-secondary education requirement (Okanagan College) Not a weekend course - legitimate professional designation Minimum 70% passing grade required Family Legacy Component Licensed business can transfer to spouse and children Keeps client relationships within the family unit Different from traditional firms where clients "roll up" to the company Creates true generational wealth opportunity Work-Life Balance Benefits No commuting (Chris previously spent ~1 day/week in vehicle) Flexible schedule for family events and activities Ability to work while traveling Geographic freedom - clients across Canada via virtual meetings Success Stories Rebecca Matthews: Went from multiple six figures in debt to running one of the fastest-growing agencies, earning $250K/year Team members earning from $500-2000/month part-time to $250K+ full-time Couples working together successfully in the business   Let's dive in! Thank you for joi ning us today. If you could rate, review & subscribe, it would mean the world to me! While you're at it, take a screenshot and tag me @jennpike to share on Instagram – I'll re-share that baby out to the community & once a month I'll be doing a draw from those re-shares and send the winner something special! Click here to listen: Apple Podcasts – CLICK HERESpotify – CLICK HERE Free Resources: Free Perimenopause Support Guide | jennpike.com/perimenopausesupport Free Blood Work Guide | jennpike.com/bloodworkguide The Simplicity Sessions Podcast | jennpike.com/podcast Get 20% on thewalkingpad.com using code "JENNPIKE20" Get discounts at happybumco.com using code "JENNPIKE" *code doesn't apply with Black Friday sale* Programs: Ignite: Your 8-Week Body Transformation Program | https://jennpike.com/ignite The Peri & Menopause Project  - Join the Waitlist | jennpike.com/theperimenopauseproject Synced Virtual Fitness Studio | jennpike.com/synced Services: Work With Jenn | https://jennpike.com/work-with-jenn/ Functional Testing | jennpike.com/testing-packages Business Mentorship | The Audacious Woman Mentorship:  jennpike.com/theaudaciouswoman Connect with Jenn: Instagram | @jennpike Facebook | @thesimplicityproject YouTube | Simplicity TV Website | The Simplicity Project Inc. Connect with Chris: Instagram | @chrisborsellino Finance Discovery Session | Book Here Have a question? Send it over to hello@jennpike.com and I'll do my best to share helpful insights, thoughts and advice.

The Tournament of Champions continues apace this week, as we finish off the quarterfinals and the semifinals and get ready for next week's finals by...watching an exhibition game. We have some thoughts on that as well as some of the stellar gameplay this week including a "Welcome to Next Year's JIT" performance from Tom Devlin and a down-to-the-wire finish between Cameron Berry and Paolo Pasco. Emily also LOVES a geography category this week, John receives an extremely weird heckle, and Fox News gets in on the Jeopardy! reporting game. Plus, we dive deep on Jean-Paul Marat's murderer, Charlotte Corday. If you want to murder some more Jeopardy! content, you can head on over to our Patreon for a bunch of bonus content. You'll get immediate access to our entire back catalogue, our wonderful Discord (with several J! champs hanging out in there), and a brand-new bonus episode every month, like last week's, which featured the JIT's Alison Betts and Drew Goins playing a rock and metal board to help them prepare. Join today at patreon.com/jeopardypodcast. SOURCE: The Science Survey: "The Angel of Assassination: A Profile on Charlotte Corday" by Winnie Huang Special thank you as always to the Jeopardy! Fan and J-Archive. This episode was produced by Producer Dan. Music by Nate Heller. Art by Max Wittert.

Today we are breaking down Games Workshop. This episode is another examination of the business of IP. Whether it's Disney, Electronic Arts, or Nintendo, there are so many businesses built around core IP. And while Games Workshop and its Warhammer franchise may not be as familiar to our North America listeners - this episode will tell you why that may be changing very soon. My guest is Todd Wenning, President and CIO of KNA Capital. Todd shares his own personal story uncovering Games Workshop many years ago, he gets into the fun evolution of this business which ties into the vertical integration today, and he shares what lies ahead as awareness of Warhammer's loyal enthusiasts welcome more into their world. For the full show notes, transcript, and links to the best content to learn more, check out the episode page⁠⁠⁠⁠⁠⁠⁠ here.⁠⁠⁠⁠⁠⁠⁠ — This episode is brought to you by⁠⁠⁠⁠ ⁠Portrait Analytics⁠⁠⁠⁠⁠ - your centralized resource for AI-powered idea generation, thesis monitoring, and personalized report building. Built by buy-side investors, for investment professionals. We work in the background, helping surface stock ideas and thesis signposts to help you monetize every insight. In short, we help you understand the story behind the stock chart, and get to "go, or no-go" 10x faster than before. Sign-up for a free trial today at⁠⁠⁠⁠ ⁠portraitresearch.com⁠⁠⁠⁠⁠ — Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit⁠⁠⁠⁠⁠⁠⁠ colossus.com/episodes⁠⁠⁠⁠⁠⁠⁠. Editing and post-production work for this episode was provided by The Podcast Consultant (⁠⁠⁠⁠⁠⁠⁠https://thepodcastconsultant.com⁠⁠⁠⁠⁠⁠⁠). Timestamps  (00:00:00) Welcome to Business Breakdowns (00:03:55) Introduction to Games Workshop  (00:05:31) History of the Warhammer IP  (00:09:14) Games Workshop's Evolution  (00:10:59) Warhammer Retail Stores  (00:12:37) The Numbers Behind Warhammer's Popularity  (00:14:03) Geographic and Demographic Concentration  (00:16:36) Competition from Other Games & Hobbies  (00:18:49) Events and Community: Hidden Network Effects  (00:19:48) Margins and Cash Generation  (00:21:31) Growth Drivers & Prime Potential  (00:24:51) Licensing Model & Tariff Volatility  (00:26:49) Why the Business is Defensible  (00:28:33) The Relevance Risk  (00:31:43) Games Workshop's Unique Flat Structure  (00:32:52) Capital Allocation & Dividend Focus  (00:34:16) Valuing Games Workshop  (00:35:25) Three Man Risks for the Business  (00:38:33) Riches in Niches & Other Lessons

This episode's Community Champion Sponsor is Ossur. To learn more about their ‘Responsible for Tomorrow' Sustainability Campaign, and how you can get involved: CLICK HEREEpisode Overview: Geography should never determine whether a patient lives or dies.Our next guest, Dr. Sarah Matt, is on a mission to make that vision a reality.A surgeon turned health technology strategist, Sarah has spent over two decades breaking down the barriers that separate patients from care.From leading Oracle's $28 billion Cerner integration to architecting the first U.S. remote robotic surgery network, she's been at the forefront of healthcare's digital transformation.Now, as a national bestselling author of The Borderless Healthcare Revolution, Sarah is equipping healthcare leaders with a practical framework to eliminate physical, financial, cultural, digital, and trust barriers to care.Join us to discover how we can build a truly borderless healthcare system. Let's go!Episode Highlights:Five Pillars of Access: Physical, financial, cultural, digital, and trust barriers—with cultural and trust most overlookedFrom Bedside to Billions: Sarah left the OR to impact millions through technology instead of 20 patients a day2026 is the Year of Catch Up: Fix data governance and interoperability before AI can deliver real resultsActionable Over Theoretical: Every chapter includes a builder's box and checklist for immediate actionNew Leadership Required: Leaders must think faster, embrace uncertainty, and operate in the gray zoneAbout our Guest:Sarah Matt, MD, MBA, is a surgeon turned health technology strategist, author, and speaker. Her work focuses on how digital tools, from remote surgery to telemedicine to AI, can expand access to healthcare and eliminate the traditional boundaries that separate patients from care.With over two decades of experience at the intersection of medicine and innovation, Dr. Matt has held leadership roles at Oracle Health, NextGen, and multiple health tech startups. She has designed and deployed systems that reach patients around the world, including hard-to-serve and underserved populations.A practicing physician, Dr. Matt continues to treat patients in rural and charity-based settings, keeping her closely connected to the human side of healthcare access. She speaks widely at healthcare and technology conferences and has appeared on national panels about artificial intelligence, care delivery reform, and digital transformation. She is also the author of The Borderless Healthcare Revolution: The Definitive Guide to Breaking Geographic Barriers Through Technology.A graduate of Cornell University, SUNY Upstate Medical University and UT Austin's McCombs School of Business, she blends clinical acumen with deep technical knowledge to challenge the status quo and to reimagine what healthcare can look like when geography no longer dictates your care.Links Supporting This Episode: Dr. Sarah Matt Website: CLICK HERE

In this episode of Excess Returns, Redfin Chief Economist Daryl Fairweather joins Matt Zeigler to unpack what she calls the Great Housing Reset. Rather than a housing crash or correction, Fairweather argues the market is entering a multi year transition toward something more normal, where incomes gradually catch up to home prices and affordability improves at the margin. The conversation covers mortgage rates, supply constraints, regional housing dynamics, climate risk, policy tradeoffs, and how AI is reshaping real estate decisions for buyers, renters, and investors.Topics covered in this episode• Why the current housing market is a reset, not a crash or correction• How income growth outpacing home price growth could slowly improve affordability• Mortgage rate dynamics and why rates may stay near the low 6 percent range• The mortgage rate lock in effect and why inventory may take years to normalize• Regional housing trends including the Midwest, Northeast, Sunbelt, and tech hubs• The role of wages, rents, and affordability for Gen Z and first time homebuyers• Investor activity, rental markets, and the outlook for housing as an investment• Immigration, foreign buyers, and local market distortions• Multi generational living, ADUs, and creative housing solutions• Housing policy ideas that actually address supply constraints• Why demand side policies like 50 year mortgages miss the real problem• Climate risk, insurance costs, and total cost of home ownership• How AI and conversational search are changing the home buying process• The future of MLS consolidation and real estate market structure• Practical guidance for renters, buyers, and homeowners looking ahead to 2026Timestamps00:00 Introduction and the Great Housing Reset02:00 What a housing reset really means03:30 Income growth versus home price growth05:20 Mortgage rates and the outlook for borrowing costs08:40 Fed policy, bond markets, and mortgage rates10:40 Inventory shortages and the lock in effect12:30 Regional housing market winners and losers16:00 Affordability challenges for younger buyers19:00 Rental markets and investor dynamics21:20 Multi generational living and ADUs25:00 Housing policy and supply constraints29:30 Why 50 year mortgages do not solve affordability33:00 Geographic housing outlook by life stage39:30 Climate risk, insurance, and housing costs47:00 Energy efficiency and dense housing50:20 AI, real estate search, and market structure54:30 What to watch in the housing market through 202659:30 Book discussion and where to follow Daryl Fairweather

Geographic origins and genetics of eastern and Great Lakes mallardsEric Lance is a wildlife biologist, ecologist, researcher and professor in Ohio who brings the facts about waterfowl migration and habitat to the episode, discussing the flooded corn debate and what weather patterns are changing to affect waterfowl.Lance Ecology Lab: https://www.lanceecologylab.com/Feathered Skies Podcast: https://www.instagram.com/featheredskiespodcast/?hl=hrGeographic origins and genetics of eastern and Great Lakes mallards: https://wildlife.onlinelibrary.wiley.com/doi/abs/10.1002/jwmg.70099Support this podcast at — https://redcircle.com/toomanyhobbies/donations

Send us a textThe Outlaws return with a new episode as Hughesy joins after his winter break. Top 5 - Fads from our teenage years, 5 crazy questions, over/under, this or that and rabbit holeSupport the show#outlawblitz @outlawblitz

Episode 144Happy New Year! This is one of my favorite episodes of the year — for the fourth time, Nathan Benaich and I did our yearly roundup of AI news and advancements, including selections from this year's State of AI Report.If you've stuck around and continue to listen, I'm really thankful you're here. I love hearing from you.You can find Nathan and Air Street Press here on Substack and on Twitter, LinkedIn, and his personal site. Check out his writing at press.airstreet.com.Find me on Twitter (or LinkedIn if you want…) for updates on new episodes, and reach me at editor@thegradient.pub for feedback, ideas, guest suggestions.Outline* (00:00) Intro* (00:44) Air Street Capital and Nathan world* Nathan's path from cancer research and bioinformatics to AI investing* The “evergreen thesis” of AI from niche to ubiquitous* Portfolio highlights: Eleven Labs, Synthesia, Crusoe* (03:44) Geographic flexibility: Europe vs. the US* Why SF isn't always the best place for original decisions* Industry diversity in New York vs. San Francisco* The Munich Security Conference and Europe's defense pivot* Playing macro games from a European vantage point* (07:55) VC investment styles and the “solo GP” approach* Taste as the determinant of investments* SF as a momentum game with small information asymmetry* Portfolio diversity: defense (Delian), embodied AI (Syriact), protein engineering* Finding entrepreneurs who “can't do anything else”* (10:44) State of AI progress in 2025* Momentous progress in writing, research, computer use, image, and video* We're in the “instruction manual” phase* The scale of investment: private markets, public markets, and nation states* (13:21) Range of outcomes and what “going bad” looks like* Today's systems are genuinely useful—worst case is a valuation problem* Financialization of AI buildouts and GPUs* (14:55) DeepSeek and China closing the capability gap* Seven-month lag analysis (Epoch AI)* Benchmark skepticism and consumer preferences (”Coca-Cola vs. Pepsi”)* Hedonic adaptation: humans reset expectations extremely quickly* Bifurcation of model companies toward specific product bets* (18:29) Export controls and the “evolutionary pressure” argument* Selective pressure breeds innovation* Chinese companies rushing to public markets (Minimax, ZAI)* (21:30) Reasoning models and test-time compute* Chain of thought faithfulness questions* Monitorability tax: does observability reduce quality?* User confusion about when models should “think”* AI for science: literature agents, hypothesis generation* (23:53) Chain of thought interpretability and safety* Anthropomorphization concerns* Alignment faking and self-preservation behaviors* Cybersecurity as a bigger risk than existential risk* Models as payloads injected into critical systems* (27:26) Commercial traction and AI adoption data* Ramp data: 44% of US businesses paying for AI (up from 5% in early 2023)* Average contract values up to $530K from $39K* State of AI survey: 92% report productivity gains* The “slow takeoff” consensus and human inertia* Use cases: meeting notes, content generation, brainstorming, coding, financial analysis* (32:53) The industrial era of AI* Stargate and XAI data centers* Energy infrastructure: gas turbines and grid investment* Labs need to own models, data, compute, and power* Poolside's approach to owning infrastructure* (35:40) Venture capital in the age of massive GPU capex* The GP lives in the present, the entrepreneur in the future, the LP in the past* Generality vs. specialism narratives* “Two or 20”: management fees vs. carried interest* Scaling funds to match entrepreneur ambitions* (40:10) NVIDIA challengers and returns analysis* Chinese challengers: 6x return vs. 26x on NVIDIA* US challengers: 2x return vs. 12x on NVIDIA* Grok acquired for $20B; Samba Nova markdown to $1.6B* “The tide is lifting all boats”—demand exceeds supply* (44:06) The hardware lottery and architecture convergence* Transformer dominance and custom ASICs making a comeback* NVIDIA still 90–95% of published AI research* (45:49) AI regulation: Trump agenda and the EU AI Act* Domain-specific regulators vs. blanket AI policy* State-level experimentation creates stochasticity* EU AI Act: “born before GPT-4, takes effect in a world shaped by GPT-7”* Only three EU member states compliant by late 2025* (50:14) Sovereign AI: what it really means* True sovereignty requires energy, compute, data, talent, chip design, and manufacturing* The US is sovereign; the UK by itself is not* Form alliances or become world-class at one level of the stack* ASML and the Netherlands as an example* (52:33) Open weight safety and containment* Three paths: model-based safeguards, scaffolding/ecosystem, procedural/governance* “Pandora's box is open”—containment on distribution, not weights* Leak risk: the most vulnerable link is often human* Developer–policymaker communication and regulator upskilling* (55:43) China's AI safety approach* Matt Sheehan's work on Chinese AI regulation* Safety summits and China's participation* New Chinese policies: minor modes, mental health intervention, data governance* UK's rebrand from “safety” to “security” institutes* (58:34) Prior predictions and patterns* Hits on regulatory/political areas; misses on semiconductor consolidation, AI video games* (59:43) 2026 Predictions* A Chinese lab overtaking US on frontier (likely ZAI or DeepSeek, on scientific reasoning)* Data center NIMBYism influencing midterm politics* (01:01:01) ClosingLinks and ResourcesNathan / Air Street Capital* Air Street Capital* State of AI Report 2025* Air Street Press — essays, analysis, and the Guide to AI newsletter* Nathan on Substack* Nathan on Twitter/X* Nathan on LinkedInFrom Air Street Press (mentioned in episode)* Is the EU AI Act Actually Useful? — by Max Cutler and Nathan Benaich* China Has No Place at the UK AI Safety Summit (2023) — by Alex Chalmers and Nathan BenaichResearch & Analysis* Epoch AI: Chinese AI Models Lag US by 7 Months — the analysis referenced on the US-China capability gap* Sara Hooker: The Hardware Lottery — the essay on how hardware determines which research ideas succeed* Matt Sheehan: China's AI Regulations and How They Get Made — Carnegie EndowmentCompanies Mentioned* Eleven Labs — AI voice synthesis (Air Street portfolio)* Synthesia — AI video generation (Air Street portfolio)* Crusoe — clean compute infrastructure (Air Street portfolio)* Poolside — AI for code (Air Street portfolio)* DeepSeek — Chinese AI lab* Minimax — Chinese AI company* ASML — semiconductor equipmentOther Resources* Search Engine Podcast: Data Centers (Part 1 & 2) — PJ Vogt's two-part series on XAI data centers and the AI financing boom* RAAIS Foundation — Nathan's AI research and education charity Get full access to The Gradient at thegradientpub.substack.com/subscribe

Brianne Mees, CEO of Tender Loving Empire, shares how a people-first background in psychology and social work shaped the culture of a retail brand built to champion artists, makers, and small businesses. Brianne walks through the company's growth from a scrappy early storefront to seven locations (including airport stores), the toughest leadership decisions during the pandemic, and why mission alignment is the anchor for hiring and culture. Brandon and Brianne also explore "regenerative retail," community investing through Wefunder, and how leaders can build a business that supports local economies without losing sight of sustainability and scale. Key Timestamps 00:00 What the show is about + sponsor message from Xenium HR 01:00 Introducing Brianne Mees and the Tender Loving Empire mission 03:00 Brianne's unconventional path: psychology, social work, and a people-first approach 04:40 Why Tender Loving Empire started as a "helping profession" for artists and makers 05:00 The business today: seven retail locations, hundreds of makers, and a record label 06:00 The early days: starting before major online platforms existed for creators 07:00 The turning point: moving locations, hiring the first employee, and shifting from hobby to sustainable business 08:40 How Brianne's psychology background supported hiring and leadership 09:20 Scaling a creative retail brand into airports without losing the "feel" 10:00 Becoming "Portland tour guides" and translating local culture for travelers 12:00 Leading through the pandemic: scrappiness, resilience, and hard choices 13:00 The toughest day: furloughing the team while keeping leadership in place 13:50 Post-pandemic momentum: new airport locations and +$3M in annual revenue 14:10 How they keep 65 employees aligned: mission fit and kindness 15:20 The "Empire" name origin and the heart of the brand 15:40 The impact: celebrating $20M returned to artists and makers 16:00 Vendor selection today: buying team, data-driven decisions, and mission alignment 17:00 The ripple effect: vendors who reinvest through sustainability and social impact 18:00 Geographic focus: Portland and the broader Pacific Northwest 19:00 Why music remains the heart and soul of the brand 19:10 Why Tender Loving Empire chose Wefunder and community investing 20:40 Why VC is not the right fit for a values-based retail brand 21:20 How their Wefunder raise works: $1.2M goal and a convertible note approach 23:00 Advice to her 2007 self: confidence, trusting instincts, and staying close to the core 25:00 Preparing leaders for the next growth phase: transparency and sharing the full vision 27:20 What keeps Brianne going on tough days: impact, community, and walking into the stores 28:50 "Regenerative retail" explained: supporting communities vs. extracting from them 29:50 A first step for leaders: rethink suppliers and where resources flow 30:30 AI and the creator economy: efficiency benefits vs. IP and compensation concerns 33:00 Founder advice: grit, tenacity, support systems, and learning along the way 33:40 Closing: how listeners can support Tender Loving Empire and invest (starting at $100) 34:00 Podcast disclaimer and wrap-up A QUICK GLIMPSE INTO OUR PODCAST Podcast: Transform Your Workplace, sponsored by Xenium HR Host: Brandon Laws In Brandon's own words: "The Transform Your Workplace podcast is your go-to source for the latest workplace trends, big ideas, and time-tested methods straight from the mouths of industry experts and respected thought-leaders." About Xenium HR Xenium HR is on a mission to transform workplaces by providing expert outsourced HR and payroll services for small and medium-sized businesses. With a people-first approach, Xenium helps organizations create thriving work environments where employees feel valued and supported. From navigating compliance to enhancing workplace culture, Xenium offers tailored solutions that empower growth and simplify HR. Whether managing employee relations, payroll processing, or implementing impactful training programs, Xenium is the trusted partner businesses rely on to elevate their workplace experience. Discover how Xenium can transform your workplace: Learn more [https://www.xeniumhr.com/] Connect with Brandon Laws: LinkedIn [https://www.linkedin.com/in/lawsbrandon] Instagram [https://www.instagram.com/lawsbrandon] About [https://xeniumhr.com/about-xenium/meet-the-team/brandon-laws] Connect with Xenium HR: Website [https://xeniumhr.com/] LinkedIn [https://www.linkedin.com/company/xenium-hr] Facebook [https://www.facebook.com/XeniumHR] Twitter [https://twitter.com/XeniumHR] Instagram [https://www.instagram.com/xeniumhr] YouTube [https://www.youtube.com/user/XeniumHR

Discover the strategy to turn your geographic farm into a consistent, six-figure income stream. Many agents make the mistake of picking a farm simply because they like the neighborhood, leading to frustration and poor results, even with consistent mailing. The key is strategic farming—building a predictable pipeline instead of just brand awareness. To find a profitable farm that actually pays you back, follow these four critical steps:Exploit Your Advantage: Start where you have existing roots or currently live. Being a familiar voice that sounds like a neighbor, not a salesperson, gives you a massive edge.Calculate the Turnover Rate: This rate reveals how many homes sell annually. The calculation is the number of homes sold in the last 12 months divided by the total homes in the area. You want a sweet spot of 3% to 6%, where anything above 6% is considered "gold". Farms below 3% are too slow.Analyze the Competition: Look at who is already farming the area. If the neighborhood is saturated with six or more agents sending similar postcards, you're entering a "money pit" where you'll spend more and stand out less. One or two competitors is manageable, suggesting the area responds well to mail.Follow the Inventory and Price Point: Focus on areas where homes move regularly at strong, mid-range price points. Avoid areas where homes are priced so high they rarely move or so low that the commission can't sustain your marketing.12Maximize Your Farm Size for Six Figures:Most agents choose farms that are too small, often only 300 to 400 homes. For a six-figure income potential, the ideal sweet spot is between 1,200 to 1,500 homes. For example, if your commission averages $7,000 and you aim for $100,000 from your farm (requiring 15 closed homes), a 4% turnover rate means your farm needs about 1,429 homes.Stop gambling with your marketing and start investing in your business by choosing your farm intentionally.Join the free lunch and learn at thehyperlocalagent.com/class to get the formulas, maps, and examples for picking, measuring, and scaling your profitable farm

Pediatrician Yair Bannett studies and treats ADHD in preschool-age children. His interests stem from watching too many families struggle to understand their child's behavior. He now focuses on improving frontline care using artificial intelligence to analyze electronic health records. One recent study explored whether doctors are making appropriate non-drug interventions before choosing to medicate children. Through his research, he hopes to raise the standard of ADHD care for thousands – and perhaps millions – of children. Early diagnosis and better care can prevent later problems, Bannett tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Episode Reference Links:Stanford Profile: ​​Yair Bannett Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Yair Bannett, a developmental behavioral pediatrician at Stanford University.(00:03:44) Why Study ADHDYair's path from primary care pediatrics to ADHD research.(00:04:32) Understanding ADHDThe core symptoms and diagnostic criteria for ADHD.(00:05:57) Diagnosing ADHD in YouthWhy diagnosis is challenging and relies on clinical judgment.(00:08:21) Known Causes of ADHDWhat is known about biological origins and environmental influence.(00:10:08) Geographic and Cultural DifferencesThe variations in ADHD prevalence across regions and populations.(00:11:37) ADHD Across CountriesPrevalence of ADHD globally and challenges with monitoring diagnosis.(00:12:23) Natural History of Untreated ADHDThe lifelong persistence of ADHD and associated risks when untreated.(00:14:28) ADHD Diagnosis in AdultsThe challenges in identifying and diagnosing ADHD later in life.(00:16:27) ADHD TreatmentsAn overview of the two treatment interventions used to treat ADHD.(00:18:16) Stimulant MedicationsThe effectiveness and long-term benefits of stimulant treatments.(00:21:30) Non-Stimulant MedicationsWhen and why alternative medications for ADHD are used.(00:22:31) Non-pharmacological InterventionsThe alternative interventions used outside pharmacological treatments.(00:23:18) Reducing Household ChaosStrategies for structure and behavior management within the home.(00:24:55) Measuring Quality of ADHD CareUsing electronic health records and AI to improve treatment.(00:28:10) Importance of Early DiagnosisThe benefits of identifying ADHD before school entry.(00:29:29) Future In a MinuteRapid-fire Q&A: applying AI, collaboration, and theatre dreams.(00:31:55) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, I'm joined by Virginie Raphael — investor, entrepreneur, and philosopher of work — for a wide-ranging conversation about incentives, technology, and how we build systems that scale without losing their humanity. We talk about her background growing up around her family's flower business, and how those early experiences shaped the way she thinks about labor, value, and operating in the real economy. That foundation carries through to her work as an investor, where she brings an operator's lens to evaluating businesses and ideas. We explore how incentives quietly shape outcomes across industries, especially in healthcare. Virginie shares why telehealth was a meaningful shift and what needs to change to move beyond one-to-one, supply-constrained models of care. We also dig into AI, venture capital, and the mistakes founders commonly make today — from hiring sales teams too early to raising too much money too fast. Virginie offers candid advice on pitching investors, why thoughtful cold outreach still works, and how doing real research signals respect and fit. The conversation closes with a contrarian take on selling: why it's not a numbers game, how focus and pre-qualification drive better outcomes, and why knowing who not to target is just as valuable as finding the right people. If you're thinking about the future of work, building with intention, or navigating entrepreneurship in an AI-accelerated world, this episode is for you. And for more conversations like this, join us at Snafu Conference 2026 on March 5th, where we'll keep exploring incentives, human skills, and what it really takes to build things that last. Start (0:00) Reflections on Work, Geography, and AI Adoption Virginie shares what she's noticing as trends in work and tech adoption: Geographic focus: she's excited to explore AI adoption outside traditional tech hubs. Examples: Atlanta, Nashville, Durham, Utah, Colorado, Georgia, North Carolina, parts of the Midwest. Rationale: businesses in these regions may adopt AI faster due to budgets, urgency, and impatience for tech that doesn't perform. "There are big corporates, there are middle and small businesses in those geos that have budget that will need the tech… and/or have less patience, I should say, for over-hub technologies that don't work." She notes that transitions to transformational technology never happen overnight, which creates opportunities: "We always underestimate how much time a transition to making anything that's so transformational… truly ubiquitous… just tends to think that it will happen overnight and it never does." Robin adds context from her own experience with Robin's Cafe and San Francisco's Mission District: Observed cultural and business momentum tied to geography Mentions Hollywood decline and rise of alternative media hubs (Atlanta, Morocco, New Jersey) Virginie reflects on COVID's impact on workforce behaviors: Opened a "window" to new modes of work and accelerated change: "There were many preexisting trends… but I do think that COVID gave a bit of a window into what was possible." Emphasis on structural change: workforce shifts require multi-year perspective and infrastructure, not just trends. Investor, Mission, and Capital Philosophy Virginie clarifies she is an investor, not a venture capitalist, resisting labels and prestige metrics. "I don't call myself a venture capitalist… I just say investor." Focuses on outcomes over categories, investing in solutions that advance the world she wants to see rather than chasing trendy tech sectors. "The outcome we want to see is everyone having the mode of work that suits them best throughout their lives." Portfolio themes: Access: helping people discover jobs they wouldn't otherwise know about. Retention / support: preventing workforce dropouts, providing appropriate healthcare, childcare, and caregiving support. "Anyone anywhere building towards that vision is investible by us." Critiques traditional venture capital practices: Raising VC money is not inherently a sign of success. "Raising from a VC is just not a sign of success. It's a milestone, not the goal." Concerned about concentration of capital into a few funds, leaving many founders unsupported. "There's a sense… that the work we do commands a lot less power in the world, a lot less effectiveness than holding the capital to hire that labor." Emphasizes structural, mission-driven investing over chasing categories: Invests in companies that prevent workforce dropouts, expand opportunity, and create equitable access to meaningful work. Portfolio strategy is diversified, focusing on infrastructure and long-term impact rather than quick wins. "We've tracked over time what type of founders and what type of solutions we attract and it's exactly the type of deal that we want to see." Reflects on COVID and societal trends as a lens for her investment thesis: "COVID gave a bit of a window into what was possible," highlighting alternative modes of work and talent distribution that are often overlooked. Labor, Ownership, and Durable Skills Virginie reframes the concept of labor, wages, and ownership: "The word labor in and of itself… is something we need to change." Interested in agency and ownership as investment opportunities, especially for small businesses transitioning to employee ownership. "For a very long time… there's been a shift towards knowledge work and how those people are compensated. If you go on the blue-collar side… it's about wages still and labor." Emphasizes proper capitalization and alignment of funds to support meaningful exits for smaller businesses, rather than chasing massive exits that drive the VC zeitgeist. AI fits into this discussion as part of broader investment considerations. Childhood experience in family flower business shaped her entrepreneurial and labor perspective: Selling flowers, handling cash, and interacting with customers taught "durable skills" that persisted into adulthood. "When I think of labor, I think of literally planting pumpkin plants… pulling espresso shots… bringing a customer behind the counter." Observing her father start a business from scratch instilled risk-taking and entrepreneurial spirit. "Seeing my dad do this when I was seven… definitely part of that." Skills like sales acumen, handling money, and talking to adults were early lessons that translated into professional confidence. Non-linear career paths and expanding exposure to opportunity: Concerned that students often see only a narrow range of job options: "Kids go out of high school, they can think of three jobs, two of which are their parents' jobs… Surely because we do a poor job exposing them to other things." Advocates for creating more flexible and exploratory career pathways for young people and adults alike. Durable skills and language shaping work: Introduction of the term "durable skills" reframes how competencies are understood: "I use it all the time now… as a proof point for why we need to change language." Highlights the stigma and limitations of words like "soft skills" or "fractional work": Fractional roles are high-impact and intentional, not temporary or inferior. "Brilliant people who wanna work on a fractional basis… they truly wanna work differently… on a portfolio of things they're particularly good at solving." Work in Progress uses language intentionally to shift perceptions and empower people around work. Cultural significance of language in understanding work and people: Virginie notes that language carries stigma and meaning that shapes opportunities and perception. References Louis Thomas's essays as inspiration for attention to the nuance and power of words: He'll take the word discipline and distill it into its root, tie it back into the natural world." Robin shares a personal anecdote about language and culture: "You can always use Google Translate… but also it's somebody learning DIA or trying to learn dharia, which is Moroccan Arabic… because my fiance is Moroccan." Human-Positive AI, Process, and Apprenticeship Virginie emphasizes the value of process over pure efficiency, especially in investing and work: "It's not about the outcome often, it's about the process… there is truly an apprenticeship quality to venture and investing." Using AI to accelerate tasks like investment memos is possible, but the human learning and iterative discussion is critical: "There's some beauty in that inefficiency, that I think we ought not to lose." AI should augment human work rather than replace the nuanced judgment, particularly in roles requiring creativity, judgment, and relationship-building: "No individual should be in a job that's either unsafe or totally boring or a hundred percent automatable." Introduces the term "human-positive AI" to highlight tools that enhance human potential rather than simply automate tasks: "How do we use it to truly augment the work that we do and augment the people?" Project selection and learning as a metric of value: Virginie evaluates opportunities not just on outcome, but what she will learn and who she becomes by doing the work: "If this project were to fail, what would I still learn? What would I still get out of it?" Cites examples like running a one-day SNAFU conference to engage people in human-centered selling principles: "Who do I become as a result of doing that is always been much more important to me than the concrete outcomes of this thing going well." AI Bubble, Transition, and Opportunity Discusses the current AI landscape and the comparison to past tech bubbles: "I think we're in an AI bubble… 1999 was a tech bubble and Amazon grew out of it." Differentiates between speculative hype and foundational technological transformation: "It is fundamental. It is foundational. It is transformative. There's no question about that." Highlights the lag between technological introduction and widespread adoption: "There's always a pendulum swing… it takes time for massively transformative technology to fully integrate." AI as an enabler, not a replacement: Transition periods create opportunity for investment and human-positive augmentation. Examples from healthcare illustrate AI's potential when applied correctly: "We need other people to care for other people. Should we leverage AI so the doctor doesn't have to face away from the patient taking notes? Yes, ambient scribing is wonderful." Emphasizes building AI around real human use cases and avoiding over-automation: "What are the true use cases for it that make a ton of sense versus the ones we need to stay away from?" History and parallels with autonomous vehicles illustrate the delay between hype and full implementation: Lyft/Uber example: companies predicted autonomous vehicles as cost drivers; the transition opened up gig work: "I was a gig worker long before that was a term… the conversation around benefits and portability is still ongoing." AI will similarly require time to stabilize and integrate into workflows while creating new jobs. Bias, Structural Challenges, and Real-World AI Experiments Discusses the importance of addressing systemic bias in AI and tech: Shares the LinkedIn "#WearThePants" experiment: women altered gender identifiers to measure algorithmic reach: "They changed their picture, in some cases changed their names… and got much more massive reach." Demonstrates that AI can perpetuate structural biases baked into systems and historical behavior: "It's not just about building AI that's unbiased; it's about understanding what the algorithm might learn from centuries of entrenched behavior." Highlights the ongoing challenge of designing AI to avoid reinforcing existing inequities: "Now you understand the deeply structural ingrained issues we need to solve to not continue to compound what is already massively problematic." Parenting, Durable Skills, and Resilience Focus on instilling adaptability and problem-solving in children: "I refuse to problem solve for them. If they forget their homework, they figure it out, they email the teacher, they apologize the next day. I don't care. I don't help them." Emphasizes allowing children to navigate consequences themselves to build independence: "If he forgets his flute, he forgets his flute. I am not making the extra trip to school to bring him his flute." Everyday activities are opportunities to cultivate soft skills and confidence: "I let them order themselves at the restaurant… they need to look the waiter in the eye and order themselves… you need to speak more clearly or speak loudly." Cultural context and exposure shape learning: Practices like family meals without devices help children appreciate attention, respect, and communication: "No iPad or iPhone on our table… we sit properly, enjoy a meal together, and talk about things." Travel and cultural exposure are part of teaching adaptability and perspective: "We spent some time in France over the summer… the mindset they get from that is that meals matter, and people operate differently." Respecting individuality while fostering independence: "They are their own people and you need to respect that and step away… give them the ability to figure out who they are and what they like to do." Parenting as a balance of guidance and autonomy: "Feel like that was a handbook that you just offered for parenting or for management? Either one. Nobody prepares you for that… part of figuring out." Future of Work and Technology Horizons Timeframes for predicting trends: Focus on a 5-year horizon as a middle ground between short-term unpredictability and long-term uncertainty: "Five years feels like this middle zone that I'm kind of guessing in the haze, but I can kind of see some odd shapes." Short-term (6–18 months) is more precise; long-term (10–15 years) is harder to anticipate: "I'm a breezy investor. Six months at a time max… deal making between two people still matters in 18 months." Identifying emerging technologies with latent potential: Invests in technologies that are ready for massive impact but haven't yet had a "moment": "I like to look at technologies that have yet to have a moment… the combo of VR and AI is prime." Example: Skill Maker, a VR+AI training platform for auto technicians, addressing both a labor shortage and outdated certification processes: "We are short 650,000 auto technicians… if you can train a technician closer to a month or two versus two years, I promise you the auto shops are all over you." Focuses on alignment of incentives, business model innovation, and meaningful outcomes: "You train people faster, even expert technicians can benefit… earn more money… right, not as meaningful to them and not as profitable otherwise." Principles guiding technology and investment choices: Solving enduring problems rather than temporary fads: "What is a problem that is still not going to go away within the next 10–15 years?" Ensuring impact at scale while creating economic and personal value for participants: "Can make a huge difference in the lives of 650,000 people who would then have good paying jobs." Scaling, Incentives, and Opportunity Re-examining traditional practices and identifying opportunities for change: "If you've done a very specific thing the exact same way, at some point, that's prime to change." Telehealth is an example: while helpful for remote access, it hasn't fundamentally created capacity: "You're still in that one-to-one patient's relationship and an hour of your time with a provider is still an hour at a time." Next version of telehealth should aim to scale care beyond individual constraints: "Where do we take telehealth next… what is the next version of that that enables you to truly scale and change?" Incentives shape outcomes: "Thinking through that and all the incentives… if I were to change the incentives, then people would behave differently? The answer very often is yes, indeed." Paraphrasing Charlie Munger: "Look for the incentives and I can tell you the outcome." Founders, Pitching, and Common Mistakes Pet peeves in founder pitches: Lack of research and generic outreach is a major turn-off: "I can really quickly tell if you have indeed spent a fraction of a minute on my site… dear sir, automatic junk. I won't even read the thing." Well-crafted, thoughtful cold inbound pitches get attention: "Take some time. A well crafted cold inbound will get my attention… you don't need to figure out an intro." Big mistakes entrepreneurs make: Hiring too early, especially in sales: "Until you have a playbook, like don't hire a sales team… if you don't have about a million in revenue, you're probably not ready." Raising too much capital too quickly: "You get into that, you're just gonna spend a lot more time fundraising than you are building a company." Comparing oneself to others: "You don't know if it's true… there's always a backstory… that overnight success was 15 years in the making." Sales Strategy and Non-Sales Selling Approach is contrarian: focus on conversion, not volume: "It is not a numbers game. I think it's a conversion game… I would much rather spend more time with a narrower set of targets and drive better conversion." Understanding fit is key: "You gotta find your people… and just finding who is not or should not be on your list is equally valuable." Recognizes that each fund and business is unique, so a tailored approach is essential: "The pitch is better when I'm talking to the quote unquote right people in the right place about the right things." Where to Find Virginie and Her Work Resources for listeners: Full Circle Fund: fullcirclefund.io  Work in Progress: workinprogress.io  LinkedIn: Virginie Raphael  Where to Access Snafu Go to joinsnafu.com and sign up for free.  

Maps shouldn't say “graphic, clickable, blank” when what we really need is orientation. We sit down with Brandon Biggs, CEO of XR Navigation, to unpack why traditional map interfaces exclude blind, low-vision, and neurodiverse users—and how cross-sensory design transforms static visuals into reliable spatial understanding. Brandon makes a clear case that maps are not just about mobility; they're about building mental models of names, distances, directions, shapes, and relationships. Without accessible orientation tools, people lose access to critical public data and even entire careers that rely on geographic information.We dive into the promises and pitfalls of AI for mapping. Street imagery descriptions are improving, but 70% accuracy is not enough when a misread road or building can derail someone's route and safety. Audium offers an alternative grounded in authoritative data: a visual mode with readable contrast and scalable interfaces, and a nonvisual mode that feels like a game, using spatial audio and sound textures to convey features without adding cognitive overload. Every element remains text-exposed for screen readers and Braille, ensuring WCAG compliance and human verification. It's not AI versus accessibility—it's AI partnered with verifiable, inclusive design.Policy and practice are shifting. ADA Title II rules in the US begin to mandate accessible geographic maps for state and local agencies, while Europe and the UK still exclude many maps unless used for navigation, unintentionally limiting access to fields like epidemiology, planning, and environmental science. Brandon explains how Audium's Esri partnership enables agencies to convert entire map libraries in Experience Builder, drawing on ArcGIS Living Atlas, OpenStreetMap, and local datasets. From wildfire layers to zoning overlays and event wayfinding, this is a blueprint for making public spatial data usable by everyone.If accessible orientation resonates with you, join us: subscribe, share this conversation with a colleague in government or GIS, and leave a review with one change you want to see in public maps. Your feedback helps push inclusive mapping from a nice-to-have to a new standard.Send us a textSupport the showFollow axschat on social media.Bluesky:Antonio https://bsky.app/profile/akwyz.com Debra https://bsky.app/profile/debraruh.bsky.social Neil https://bsky.app/profile/neilmilliken.bsky.social axschat https://bsky.app/profile/axschat.bsky.social LinkedInhttps://www.linkedin.com/in/antoniovieirasantos/ https://www.linkedin.com/company/axschat/ https://www.linkedin.com/in/neilmilliken/Vimeohttps://vimeo.com/akwyzhttps://twitter.com/axschathttps://twitter.com/AkwyZhttps://twitter.com/neilmillikenhttps://twitter.com/debraruh

Ann Berry is joined by Gen CEO Vincent Pilette to break down Gen's business model and growth strategy following its expansion beyond cybersecurity. The conversation covers how brands like Norton, Avast, LifeLock and MoneyLion fit together, how Gen thinks about consumer trust and how financial wellness is being integrated into its core security platform. Pilette also discusses customer adoption, global expansion and how the company evaluates future adjacencies and acquisitions.00:00 – Gen CEO Vincent Pilette joins00:41 – Gen's four business pillars and operating segments02:26 – Norton's role in consumer cybersecurity02:57 – Consumer vs. B2B2C growth strategy04:15 – Customer journeys across Norton, LifeLock, and MoneyLion05:07 – Platform integration and challenges with cross-selling06:59 – Subscriber base and membership structure07:58 – Global user scale across paid and free customers08:21 – Financial wellness adoption and growth outlook09:57 – Positioning Gen for consumers and investors12:09 – Trust-based solutions13:33 – Strategic priorities and future expansion areas17:11 – Customer demand for blockchain-based solutions18:16 – Geographic mix and international growth strategyAfter Earnings is brought to you by Stakeholder Labs and Morning Brew.For more go to https://www.afterearnings.comFollow UsX: https://twitter.com/AfterEarningsTikTok: https://www.tiktok.com/@AfterEarningsInstagram: https://www.instagram.com/afterearnings_/Reach OutEmail: afterearnings@morningbrew.com$GEN Learn more about your ad choices. Visit megaphone.fm/adchoices

Kristy Akullian of Blackrock considers AI the “best game in town,” but not the only game anymore. She highlights their actively managed AI ETF (BAI), which has themes like power generation and data center buildout. She also notes that geographic diversification is important in the AI trade and that many investors are under-exposed to international equities. ======== Schwab Network ========Empowering every investor and trader, every market day.Options involve risks and are not suitable for all investors. Before trading, read the Options Disclosure Document. http://bit.ly/2v9tH6DSubscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about

Dr. Hope Rugo and Dr. Vivek Subbiah discuss innovative trial designs to enable robust studies for smaller patient populations, as well as the promise of precision medicine, novel therapeutic approaches, and global partnerships to advance rare cancer research and improve patient outcomes. TRANSCRIPT  Dr. Hope Rugo: Hello and welcome to By the Book, a podcast series from ASCO that features engaging conversations between editors and authors of the ASCO Educational Book. I am your host, Dr. Hope Rugo. I am the director of the Women's Cancers Program and division chief of breast medical oncology at the City of Hope Cancer Center [in Los Angeles]. The field of rare cancer research is rapidly transforming thanks to progress in clinical trials and treatment strategies, as well as improvements in precision medicine and next-generation sequencing that enable biomarker identification. According to the National Cancer Institute, rare cancers occur in fewer than 150 cases per million each year, but collectively, they represent a significant portion of all cancer diagnoses. And we struggle with the appropriate treatment for these rare cancers in clinical practice. Today, I am delighted to be joined by Dr. Vivek Subbiah, a medical oncologist and the chief of early-phase drug development at the Sarah Cannon Research Institute in Nashville, Tennessee. Dr. Subbiah is the lead author of a paper in the ASCO Educational Book titled "Designing Clinical Trials for Patients with Rare Cancers: Connecting the Zebras," a great title for this topic. He will be telling us about innovative trial designs to enable robust studies for small patient populations, the promise of precision medicine, and novel therapeutic approaches to improve outcomes, and how we can leverage AI now to enroll more patients with rare cancers in clinical trials. Our full disclosures are available in the transcript of this episode.  Dr. Subbiah, it is great to have you on the podcast today. Thanks so much for being here. Dr. Vivek Subbiah: Thank you so much, Dr. Rugo, and it is an honor and pleasure being here. And thank you for doing this podcast for rare cancers. Dr. Hope Rugo: Absolutely. We are excited to talk to you. And congratulations on this fantastic paper. It is such a great resource for our community to better understand what is new in the field of rare cancer research. Of course, rare cancers are complex and multifaceted diseases. And this is a huge challenge for clinical oncologists. You know, our clinics, of course, cannot be designed as we are being very uni-cancer focused to just be for one cancer that is very rare. So, oncologists have to be a jack of all trades in this area. Your paper notes that there are approximately 200 distinct types of rare and ultra-rare cancers. And, by definition, all pediatric cancers are rare cancers. Of course, clinical trials are essential for developing new treatment strategies and improving patient outcomes, and in your paper, you highlight some unique challenges in conducting trials in this rare cancer space. Can you tell us about the challenges and how really innovative trial designs, I think a key issue, are being tailored to the specific needs of patients with rare cancer and, importantly, for these trials? Dr. Vivek Subbiah: Rare cancers present a perfect storm of challenges. First, the patient populations are very small, which makes it really hard to recruit enough participants for traditional type trials. Second, these patients are often geographically dispersed across multiple cities, across multiple states, across multiple countries, across multiple zip codes. So, logistics become complicated. Third, there is often limited awareness among clinicians, which delays referrals and diagnosis. Add to that regulatory hurdles, funding constraints, and you can see why rare cancer trials are so tough to execute. To overcome these barriers, we are seeing some really creative novel trial designs. And there are four different types of trial designs that are helping with enrolling patients with rare cancers. The first one is the basket trial. So let us talk about what basket studies are. Basket studies group patients based on shared genetic biomarkers or shared genetic mutations rather than tumor type. So instead of running separate 20 to 30 to 40 trials, you can study one therapy across multiple cancers. The second type of trial is the umbrella trial. The umbrella trials flip that concept of basket studies. They focus on one cancer type but test multiple targeted therapies within it. The third category of innovative trials are the platform studies. Platform trials are another exciting innovation. They allow new treatment arms to be added or removed as the data matures and as the data evolves, making trials more adaptive and efficient. The final category are decentralized tools in traditional trials, which are helping patients participate closer to where they are so that they can sleep in their own bed, which is, I think, a game changer for accessibility.  These designs maximize efficiency and feasibility for rare cancer research and rare cancer clinical trials. Dr. Hope Rugo: I love the idea of the platform trials that are decentralized. And I know that there is a trial being worked on with ARPA-H (Advanced Research Projects Agency for Health) funding in triple-negative breast cancer as well as in lung cancer, I think, and others with this idea of a platform trial. But it is challenged, I think, by precision medicine and next-generation sequencing where some patients do not have targetable markers, or there isn't a drug to target the marker. I think those are almost the same thing. We have really seen that these precision medicine ideas and NGS have moved the needle in helping to identify genetic alterations. This helps us to be more personalized. It actually helps with platform studies to customize trial enrollment. And we hope that this will result in better outcomes. It also allows us, I think, to study drugs even in the early stage setting more effectively. How can these advances be best applied to the future of rare cancers, as well as the challenges of not finding a marker or not having a drug? Dr. Vivek Subbiah: Thank you so much for that question. I think precision medicine and next-gen sequencing, or NGS, are truly the backbone of modern precision oncology. They have transformed how we think about cancer treatment. Instead of treating based on where the tumor originated or where the tumor started, we now look at the genetic blueprint of cancer. The NGS or next-gen sequencing allows us to sequence millions of DNA fragments quickly. Twenty, 30 years ago, they said we cannot sequence a human genome. Then it took almost a decade to sequence the first human genome. Right now, we have academic centers and commercial sequencing companies that are really democratizing NGS across all sites, not just in academic centers, across all the community sites, so that NGS is now accessible. This means that we can identify these actionable alterations like picking needles in haystacks, like NTRK fusions, RET fusions, or BRAF V600E alterations, high tumor mutational burden. This might occur across not one tumor type, across several different tumor types. So for rare cancers, this is critical because some of these mutations often define the best treatment option. Here is why this matters. Personalized therapy, right? Instead of a one-size-fits-all approach, we can tailor treatment to the patient's unique molecular profile. For trial enrollment, this can definitely help because patients can join biomarker-driven trials even if their cancer type is rare or ultra-rare. NGS technology has also helped us in designing rational studies. Many times monotherapy does not work in these cancers. So we are thinking about rational combination strategies. So NGS technology is helping us. Looking ahead, I see NGS becoming routine in clinical practice, not just at major niche academic centers, but everywhere. We will see more tumor-agnostic approvals, more molecular tumor boards guiding treatment decisions in real time. And I think we are seeing an expanded biomarker setup. Previously, we used to have only a few drugs and a handful of mutations. Now with homologous recombination defects, BRCA1/2 mutation, and expanding the HRD and also immunohistochemistry, we are expanding the biomarker portfolio. So again, I personally believe that the future is precision. What I mean by precision is delivering the right drug to the right patient at the right time. And for rare cancers, this isn't just progress. It is survival. And it is maybe the only way that they can have access to these cutting-edge precision medicines. Dr. Hope Rugo: That is so important. You mentioned an important area we will get to in a moment, the tumor-agnostic therapies. But as part of talking about that, do you think that the trials should also include just standard therapies? You know, who do you give an ADC to and when with these rare cancers? Because some of them do not have biomarkers to target and it is so disappointing for patients and providers where you are trying to screen a patient for a trial or a platform trial where you have one arm with this mutation, one arm with that, and they do not qualify because they only have a p53 loss, you know? They just do not have the marker that helps them. But we see this in breast cancer all the time. And it is tough because we don't have good information on the sequencing. So I wonder, you know, just because for some of these rare cancers it is not even clear what to use when with standard treatments. And then that kind of gets into this idea of the tumor-agnostic therapies that you mentioned. There are a lot of new treatments that are being evaluated. We have seen approval of some treatments in the last few years that are tumor-agnostic and based on a biomarker. Is that the best approach as we go forward for rare cancers? And what new treatment options are most exciting to you right now? Dr. Vivek Subbiah: Tumor-agnostic therapies, really close to my heart, are real breakthrough therapies and represent a major paradigm shift in oncology. Traditionally, for the broad listeners here, we are used to thinking about designing clinical trials and therapy like where the cancer originated, breast cancer, kidney cancer, prostate cancer, lung cancer. A tumor-agnostic therapy flips that model. Instead of focusing on the organ, they target the specific genetic alteration or biomarker that drives cancer growth regardless of where the tumor started, regardless of the location of the tumor, regardless of the zip code of the tumor. So why is this so important for rare cancers? Because many rare cancers share molecular features with more common cancers. For instance, NTRK fusion might occur in pediatric sarcoma, a salivary gland tumor, or a thyroid cancer. Historically, each of these would require separate trials, which is nearly impossible, unfeasible to conduct in these ultra-rare cancers like salivary gland cancer or pediatric sarcomas. Tumor-agnostic therapies allow us to treat all those cancers with the same targeted drug if they share that biomarker. Again, we are in 2025. The first tissue-agnostic approval, the historic precedent, was in fact an immunotherapy. Pembrolizumab was approved in 2017, May 2017, as the first immunotherapy to be approved in a tumor-agnostic way for a genomic biomarker, for MSI-High and dMMR cancers. Then came the NTRK inhibitors. So today we have not one, not two, but three different NTRK inhibitors: larotrectinib, entrectinib, and repotrectinib, which show response rates of nearly more than 60 to 75% across a handful of dozens and dozens of cancer types. Then, of course, we have RET inhibitors like selpercatinib, which is approved tissue-agnostic, and pralsetinib, which also shows tissue-agnostic activity across multiple cancers. And more recently, combination therapy with a BRAF and MEK combination, dabrafenib and trametinib, received tumor-agnostic approval for all BRAF V600E tumors with the exception of colorectal cancer. And even recently, you mentioned about antibody drug conjugates. Again, I think we live in an era of antibody drug conjugates. And Enhertu, trastuzumab deruxtecan, which was used first in breast cancer, now it is approved in a histology-agnostic manner for all HER2-positive tumors defined by immunohistochemistry 3+. So again, beyond NGS, now immunohistochemistry for HER2 is also becoming a biomarker. So again, for the broad listeners here, in addition to comprehensive NGS that may allow patients to find treatment options for these rare cancers for NTRK, RET, and BRAF, immunohistochemistry for HER2 positivity is also emerging as a biomarker given that we have a new FDA approval for this. So I would say personally that these therapies are game changers because they open doors for patients who previously had no options. Instead of waiting for years for a trial in their specific cancer type, they can access a treatment based on their molecular profile. I think it is precision medicine at its finest and best. Looking ahead, the third question you asked me is what is exciting going on? I think we will see more of these approvals. My hope is that today, I think we have nine to ten approvals. My hope is that within the next 25 to 50 years, we will have at least 50 to 100 drugs approved in this space based on a biomarker, not based on a location of the tumor type. Drug targeting rare alterations like FGFR2 fusions, FGFR amplifications, ALK fusions, and even complex signatures like high tumor mutational burden. I think we will be seeing hopefully more and more drugs approved. And as sequencing becomes routine, we will identify more patients for these therapies. I think for rare cancers, this is not just innovative approach. This is essential for them to access these novel precision medicines. Dr. Hope Rugo: Yeah, that is such a good point. I do think it is critical. Interestingly in breast cancer, it hasn't been, you know, there is always like two patients in these tumor-agnostic trials, or if that. You know, I think I have seen one NTRK fusion ever. I think that highlights the importance for rare cancers. And you know, I am hoping that that will translate into some new directions for some of our rarer and impossible-to-treat subtypes of breast cancer. It is this kind of research that is really going to make a difference. But what about those people who do not have biomarkers? What if you do not fit into that? Do you think there is a possibility of trying to do treatments for rare cancers in some prospective way that would help with that? You know, it is really a huge challenge. Dr. Vivek Subbiah: Absolutely. I think, you know, you're right, usually many of these rare cancers are driven by specific biomarkers. And again, some of the pediatric salivary gland tumors or pediatric sarcomas like fibrosarcomas, they are pathognomonic with NTRK fusions. And again, given that we have a tumor-agnostic approval, now these patients have access to these therapies. And I do not think that we would have had a trial just for pediatric fibrosarcomas with NTRK fusions. So that is one way. Another way is SWOG, right? The SWOG DART [1609] had this combination dual checkpoint, it was called the DART study dual combination chemotherapy with ipi/nivo. Now here the rare cancer subtype itself becomes a biomarker and they showed activity across multiple rare cancer subtypes. They didn't require a biomarker. As long as it was a rare or ultra-rare cancer, these patients were enrolled into the SWOG DART trial and multiple arms have read out. Angiosarcoma, Kaposi sarcoma, even gestational trophoblastic disease. Again, they have shown responses in these ultra-rare, rare cancers. Sometimes they might be seeing one or two cases a whole year. And I think this SWOG effort, this cooperative group effort, really highlighted the need for such studies without biomarkers as well. Dr. Hope Rugo: That is such a fantastic example of how to try and treat patients in a collaborative way. And in the paper, you also emphasize the need for collaborative research efforts, you know, uniting resource expertise across different ways of doing research. So cooperative groups, advocacy organizations that can really help advance rare cancer research, improve access to new therapies, and I think importantly influence policy changes. I think this already happened with the agnostic approvals. Could you tell us more about that? How can we move forward with this most effectively? Dr. Vivek Subbiah: Personally, I believe that collaboration is absolutely critical and essential for rare cancer research. No single institution, no single individual, or no single state or entity can tackle these challenges alone. The patient populations are small and dispersed. So pooling resources is the only way to run these meaningful trials. Again, it is not like singing, it is like putting a huge, huge, I would say, an opera piece together. It is not a solo, vocal therapy, but rather putting a huge opera piece like Turandot. You know, you mentioned cooperative groups. Cooperative groups, as I mentioned earlier, the SWOG DART program, the ASCO [TAPUR study]. ASCO is doing a phenomenal work of the TAPUR study. Again, this ASCO TAPUR program has enrolled so many patients with rare cancers who otherwise would not have treatment options. NCI-MATCH, the global effort, right? NCI-MATCH and the ComboMATCH are great examples. They bring together hundreds of sites, thousands of clinicians to run large-scale trials that would be impossible for any individual center or institution. These trials have already changed practice. For instance, the DART demonstrated the power of immunotherapy in rare cancers and influenced NCCN guidelines. One of the arms of the NCI-MATCH study from the BRAF V600E arm contributed towards the BRAF V600E tissue-agnostic approval. So, the BRAF V600E tissue-agnostic approval was by a pooled analysis of several studies. The ROAR study, the Rare Oncology Agnostic Research study, the NCI-MATCH dataset of tumor-agnostic cohort, and another pediatric trial, and also evidence from literature and evidence of case reports. And all this pooled analysis contributed to the tissue-agnostic approval of BRAF V600E across multiple rare cancers. There are several patient advocacy organizations which are the real unsung heroes here. Groups like, for instance, we mentioned in the paper, Target Cancer Foundation, don't just raise awareness for rare cancer research, they actively connect patients to trials providing financial, emotional support, and even run their own studies like the TRACK trial. They also influence policy to make access easier. On a global scale, initiatives like DRUP in the Netherlands, the ROME study in Italy, the PCM4EU in Europe are expanding precision medicine across these borders. These collaborations accelerate research, improve trial enrollment, and ensure patients everywhere can have access to these cutting-edge therapies. Again, it is truly a team effort, right? It is a multi-stakeholder approach. Researchers, clinicians, investigators, industry, regulators, academia, patients, patient advocates, and their caregivers all working together. And it takes a village. Dr. Hope Rugo: Absolutely. I mean, what a nice response to that. And I think really exciting and it is great to see your passion about this as well. But it helps all of us, I think, getting discouraged in treating these cancers to understand what is happening moving forward. And I think it is also a fabulous opportunity for our junior colleagues as they rise up in academics to be involved in these international collaborative efforts which are further expanding. One of the things that comes up for clinical trials for patients, and I think it is highlighted with rare cancers because, as you mentioned, people are all over the place, you know, they are so rare. They are all far away. Our patients are always saying to us, "Should I go here for a phase 1 trial?" Can you talk a little bit about how we can overcome these financial and geographic burdens for the patients? You talked about having trials locally, but it is a big financial and just social burden for patients. Dr. Vivek Subbiah: Great point. Financial cost is a major barrier in rare cancer clinical trials. It is a major barrier not just in rare cancer clinical trials, but in clinical trials in general. The economics of rare cancer research are one of the toughest challenges we face. Developing a new drug is already expensive, often billions of dollars. On an average, it takes 2 billion dollars or 2.8 billion dollars according to some data from drug discovery to approval. For rare cancers, the market is tiny, which means the pharmaceutical companies have really little financial incentive to invest. That is why initiatives like the Orphan Drug Act were created to provide tax credits, grants, and market exclusivity to encourage development for rare diseases. Clinical trials themselves are expensive because the small patient populations mean longer recruitment times and higher per-patient costs. Geographic dispersion, as you mentioned, for the patients adds travel, coordination. That is why we need to think out of the box about decentralized trial infrastructure so that we can mitigate some of these expenses. Complex trial designs like basket or platform trials sometimes require sophisticated data systems and regulatory oversight. That is a challenge. And I think some of the pragmatic studies like ASCO TAPUR have overcome those challenges. Advanced technologies like next-gen sequencing and molecular profiling also add significant upfront cost to this. Funding is also limited because rare cancers receive less attention compared to common cancers. Public funding and cooperative group trials help a lot, but I think they cannot cover everything. Patient advocacy organizations sometimes step in to bridge these gaps, but sustainable financing remains a huge challenge. So, the bottom line is without financial incentives and collaborating funding models, many promising therapies for rare cancers would never make it to patients. That is why we need system-wide policy changes, global partnerships, and innovative, effective, seamless trial designs which are so critical so that they can help reduce the cost and make research feasible so that we can deliver the right drug to the right patient at the right time. Dr. Hope Rugo: There is a lot of excitement about the future integration of AI in screening. Just at the San Antonio Breast Cancer meetings, we have a number of different presentations about AI to find markers, even like HER2, and using AI where you would screen and then match patients to clinical trials. Do you have any guidance for the rare cancer community on how to leverage this technology in order to optimize patient enrollment and, I think, identification of the best treatment matches? Dr. Vivek Subbiah: I think artificial intelligence, AI, is a game-changer in the making. Right now, clinical trial is clunky. Matching patients to trial is often manual, time consuming, laborious. You need a lot of personnel to do that. AI can automate this process by analyzing genomic data, medical records, and trial eligibility criteria to find the best matches quickly, accurately, and effectively. For the community, the key is to invest in data standardization and interoperability because AI needs clean, structured data to work effectively. Dr. Hope Rugo: Thank you so much, Dr. Subbiah, for sharing these fantastic insights with us on the podcast today and for your excellent article. Dr. Vivek Subbiah: Thank you so much. Dr. Hope Rugo: We thank you, our listeners, for joining us today. You will find a link to Dr. Subbiah's Educational Book article in the transcript of this episode. And please join us again next month on By the Book for more insightful views on key issues and innovations that are shaping modern oncology.  Thank you. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:        Dr. Hope Rugo   @hoperugo   Dr. Vivek Subbiah @VivekSubbiah Follow ASCO on social media:        ASCO on X  ASCO on Bluesky       ASCO on Facebook        ASCO on LinkedIn        Disclosures:       Dr. Hope Rugo:    Honoraria: Mylan/Viatris, Chugai Pharma   Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer   Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx   Dr. Vivek Subbiah: Consulting/Advisory Role: Loxo/Lilly, Illumina, AADI, Foundation Medicine, Relay Therapeutics, Pfizer, Roche, Bayer, Incyte, Novartis, Pheon Therapeutics, Abbvie Research Funding (Inst.): Novartis, GlaxoSmithKline, NanoCarrier, Northwest Biotherapeutics, Genentech/Roche, Berg Pharma, Bayer, Incyte, Fujifilm, PharmaMar, D3 Oncology Solutions, Pfizer, Amgen, Abbvie, Mutlivir, Blueprint Medicines, Loxo, Vegenics, Takeda, Alfasigma, Agensys, Idera, Boston Biomedical, Inhibrx, Exelixis, Amgen, Turningpoint Therapeutics, Relay Therapeutics Other Relationship: Medscape, Clinical Care Options

Travis Chappell and his producer, Eric, react to a retired American couple who traded their old life in the US for a more affordable, higher-quality retirement in Malta. By downsizing their costs, leveraging rental income from their U.S. home, and tapping into cheaper healthcare and everyday expenses overseas, they've created a lifestyle they never could have afforded if they stayed put in the States. Their story is a real-world case study in using self-awareness and geography—not just income—to design a life you actually want. On this episode we talk about: How Mary and Kevin retired to Malta on Social Security and rental income Why your ideal life might be more about where you live than how much you earn The mindset shift from “big house and car” to “low overhead and freedom” Tradeoffs of retiring abroad: distance from family vs. more time and presence when you visit Countries where you can live comfortably for under $1,000 a month Why lifestyle bloat traps people in jobs they hate longer than necessary How to reverse-engineer your cost of living around the life you actually want Top 3 Takeaways You don't have to become a billionaire to live well in retirement; you may just need to move somewhere your Social Security or modest income stretches a lot further. Success starts with self-awareness—getting brutally honest about what you really want (time, freedom, experiences) instead of defaulting to status symbols like big houses and luxury cars. Geographic arbitrage is real: by lowering housing, transportation, and healthcare costs abroad, you can often buy more free time, less stress, and more meaningful time with the people you love. Notable Quotes “The choice was basically stay in the U.S. and keep working—or go to Malta and actually enjoy our retirement.” “You don't have to dedicate your life to becoming the next Steve Jobs; you just have to do the math on the life you want and engineer it on purpose.” “If you just float and let life happen to you, you get the kind of results that come from living that way—and that's not how I want to live.” ✖️✖️✖️✖️

In 1963, Dr. Chan Thomas wrote about pole shifts, mass extinctions, and Adam and Eve. The CIA classified it for 50 years. What was in the file they didn't want you to read?

Watch the full episode on our YouTube channel: youtube.com/@mreapodcastGeographic farming, done the right way, might be the biggest no-brainer in real estate. In this episode, we sit down with Jim Fagan, a Charlotte agent who built a farm so strong it delivers 44-50 percent market share in his neighborhood. He's not running a complicated strategy. He's running a *repeatable* one, and he's running it like a pro.We walk step-by-step through Jim's geographic farming system, from how to pick the right neighborhood to the monthly touches that keep him top of mind, to the real magic: front-yard community events that turn neighbors into clients.Jim also shares a deeply personal part of his story: his journey with bipolar disorder, how it reshaped his life, and why he believes people can still build a life of significance while carrying something heavy.If you want more listings, more visibility, and a farm that can feed your business for years, run this play.Resources:Read: The Millionaire Real Estate Agent by Gary Keller, Dave Jenks, and Jay Papasan  Explore: KW MAPS CoachingLearn: Command for Agents (Keller Williams) Order the Millionaire Real Estate Agent Playbook | Volume 3Connect with Jason:LinkedinProduced by NOVAThis podcast is for general informational purposes only. The views, thoughts, and opinions of the guest represent those of the guest and not Keller Williams Realty, LLC and its affiliates, and should not be construed as financial, economic, legal, tax, or other advice. This podcast is provided without any warranty, or guarantee of its accuracy, completeness, timeliness, or results from using the information.WARNING! You must comply with the TCPA and any other federal, state or local laws, including for B2B calls and texts. Never call or text a number on any Do Not Call list, and do not use an autodialer or artificial voice or prerecorded messages without proper consent. Contact your attorney to ensure your compliance.

Today's location-specific episode features Pacific Islands, a US Territory that includes American Samoa, Guam, and the Commonwealth of Northern Mariana Islands (CNMI).  Each of my location-specific podcasts is set up the same way answering the same four questions:  1) What are the basics of the in this location2) What are the nuances of this location – what is different that stands out?3) Some guidance about abandoned items left behind by a tenant in a rental inPacific Islands, a US Territory4) Where to get help in your local area in Pacific Islands, a US Territory.  Then I'll go through what I call my “Bingo Card” of standard items I see most often in tenancy laws in different locations.  This episode is NOT all inclusive – you must research further in your specific area including your County, Regional District, Parish, City or any other Governing Body that involves your rental location, but today's episode will get you started!This episode includes resources for Pacific Islands, a US Territory including:CNMI Landlord and Tenant Rental Act of 2017Marianas Office - Micronesian Legal Services CorporationU.S. Affiliated Pacific Basin Jurisdictions: Legal, Geographic and Demographic InformationU.S. Territories: Guam and Other Pacific Islands Profile - SIECUSHome - American Samoa Bar AssociationSecretary of American SamoaAmerican Samoa Legal Aid: Justice for All

Send us a textThis finale feels less like an ending and more like a graduation ceremony for everyone who has ever cared about Customer Success.In this closing chapter of the customer success playbook podcast, Kevin Metzger and Roman Trebon look back on a journey that started as a “ludicrous” idea over food and drinks and turned into a global community with nearly 13,000 downloads across countries like Australia, Israel, France, and beyond. They revisit how the show began as a simple networking experiment during a job transition and evolved into a platform for learning, connection, and real human stories behind Customer Success careers.Kevin and Roman share their favorite guests and moments—from foundational lessons on P&L and value with Dave Jackson, to onboarding excellence with Donna Weber, to conversations about imposter syndrome with Rachel Provan, and the future of AI and agents with Sam Cummings. They talk candidly about fear, courage, and the reality that neither of them knew the first thing about podcasting when they started.This episode is a reflective, warm, and occasionally cheeky goodbye to the show in its current form—and a clear pivot point toward what's coming next for both hosts, their careers, and the evolving world of Customer Success and AI.Detailed AnalysisFrom a business and leadership standpoint, this episode is a masterclass in experimentation, courage, and community-building.1. Turning a career transition into a strategic platformKevin initially launched the podcast as a networking tool while navigating a job transition. That decision paid off in multiple ways: expanded visibility, deeper relationships, and a strong professional brand. For leaders and CS professionals, this is a powerful example of turning uncertainty into leverage—using content as a strategic asset rather than just a marketing tactic.Key takeaways for operators and executives:Don't wait for the “perfect moment” to build a platform—build while you're in motion.Treat visibility, networking, and knowledge-sharing as part of your job, not an optional extra.Use long-form conversations to deepen trust with your ecosystem (customers, peers, partners, talent).2. The Customer Success community as a force multiplierRoman highlights how generous and open the Customer Success community has been—guests freely sharing their time, their expertise, and even their networks by recommending future guests. This is more than feel-good community talk; it's a blueprint for modern go-to-market.Business relevance:High-performing CS communities create compounding value: better ideas, stronger talent pipelines, and faster pattern recognition around what works.Geographic boundaries matter less when you're connecting through content; an Atlanta-based duo built a truly global audience.Investing in community creates resilience—especially in volatile job markets.3. Learning as a competitive advantage (and a personal operating system)A recurring theme in the conversation is learning: Kevin's love for learning, Roman's reflections on trying new formats, and the way every guestPlease Like, Comment, Share and Subscribe. You can also find the CS Playbook Podcast:YouTube - @CustomerSuccessPlaybookPodcastTwitter - @CS_PlaybookYou can find Kevin at:Metzgerbusiness.com - Kevin's person web siteKevin Metzger on Linked In.You can find Roman at:Roman Trebon on Linked In.

Dr. Steve Carver is Professor of Rewilding and Wilderness Science in the School of Geography, University of Leeds and Director of the Wildland Research Institute. He has over 30 years of experience in GIS and multi-criteria evaluation, with special interests in wilderness, wildlands, rewilding, landscape evaluation, and public participation. He has worked extensively on the […] Read full article: Episode 163: Steve Carver on the Challenges of Implementing Rewilding Goals Across Fragmented Geographic, Cultural, and Political Landscapes

#667: Home prices have outpaced wages for more than a decade, and first-time buyers are stretching further every year. Now a new idea is entering the conversation, the 50-year mortgage. It promises lower monthly payments, yet it reshapes everything from equity growth to long-term risk. In this episode we sit down with Karsten Jeske, PhD, CFA from Early Retirement Now, a former Federal Reserve economist known for forensic financial modeling. Together we walk through when a 50-year mortgage might make sense, when it clearly does not, and why the math is rarely as simple as “higher payment versus lower payment.” We also dig into how ultra-long mortgages could push home prices even higher, and what this means for today's buyers and tomorrow's retirees. If you've wondered whether extended loan terms offer real affordability or just disguise the cost, this conversation gives you a clearer lens. Key Takeaways Why stretching to a 50-year mortgage can look affordable on paper yet leave you with far slower equity growth in the years that matter most. The few cases where a longer mortgage term can support a deliberate strategy, such as freeing cash flow to invest, and why this only works for certain borrowers. How inflation, appreciation, and opportunity cost change the “true” math behind 30-year versus 50-year loans. Why ultra-long mortgages may raise home prices more than they help buyers and what this means for generational wealth. How late-life mortgage decisions, downsizing, and step-up in basis reshape your legacy far more than the length of the loan itself. Resources and Links Early Retirement Now blog, Karsten's research and mortgage modeling. Chapters Note: Timestamps are approximate and may vary greatly across listening platforms due to dynamically inserted ads. (00:00) 50-year mortgage debate begins (02:52) Karsten says it expands options for sophisticated investors (05:42) Paula focuses on owner-occupants who can't afford houses (11:03) Equity difference: $80K vs $20K after 10 years (18:26) Lower payments could fund other investments (25:17) Lenders package mortgages for institutional investors (29:18) US doesn't issue 100-year bonds despite stability (34:00) Small term premiums create huge returns (43:31) Paying more interest isn't automatically bad (48:08) First-time buyers now average age 40 (56:08) Geographic arbitrage enables mortgage payoff (01:00:20) 50-year mortgages could inflate home prices (01:04:51) Supply constraints drive housing affordability crisis (01:07:29) Fed might pause rate cuts in December Learn more about your ad choices. Visit podcastchoices.com/adchoices

Welcome back to The Cashflow Project! In this episode, we're joined by Marcy Sagel, founder and principal of MSA Interiors, a leading commercial interior design firm specializing in multifamily, student housing, senior living, and affordable housing projects nationwide. With over 25 years of experience, Marcy shares her journey from discovering design as a teenager to building a successful firm through multiple market cycles. We dive into the role of design in real estate, the importance of mentorship and adaptability, and how diversification and thoughtful planning lead to long-term success. Whether you're an investor, entrepreneur, or passionate about real estate and design, this episode is full of insight and inspiration. [00:00] "Design Journey and Insights" [04:55] "Efficient Project Documentation Tips" [09:55] "Reflections on Construction Projects" [12:55] "Impactful Project Visualization Tactics" [16:06] "Outdoor Space Design Insights" [20:09] Space Planning for Long-Term Durability [20:56] Long-Term Project Functionality Planning [24:51] Development Delays and Partnerships [30:01] Geographic and Strategy Diversification [32:22] "Lesson Learned Through Diversification" [35:11] "Entrepreneurship and Importance of Community" [37:14] Adaptable Strategies for Entrepreneurs Connect with Marcy Sagel! Website LinkedIn Instagram Connect with The Cashflow Project! Website LinkedIn YouTube Facebook Instagram

This is a PSA and reminder for us all that sometimes changing our circumstances (like through a move, leaving our job or a relationship etc) really is the most compassionate, wise, and liberating choice…and sometimes it's just changing what our suffering looks like on a superficial level. I'll share my own story of leaving Alaska for Spain and jam on how to know when it's helpful to change our environment and when it's not. Plus, we'll explore how Buddhist psychology can help us discern whether to stay or go.In this episode, you will learn://The myth of the “geographical cure,” and why moving abroad rarely delivers the fresh start people imagine// Why the mind always travels with us.// How to tell the difference between suffering created by our environment and suffering created by our internal patterns.// When changing circumstances is a wise, life-supporting choice, and when it becomes avoidance in disguise.// What Buddhist teachings on emptiness and perception show us about our relationship to place.// How trauma science and positive psychology explain the limits of “starting over.”// A simple reflection practice to help you discern whether you need an internal shift, an external shift, or both.Resources:// Episode 28: Practical Emptiness// Episode 29: Should I Stay or Should I Go?// Episode 202: The Healing Power of Emptiness// If you're new to the squad, grab the Rebel Buddhist Toolkit I created at RebelBuddhist.com. It has all you need to start creating a life of more freedom, adventure, and purpose. You'll also get access to the Rebel Buddhist private group, and tune in every Wednesday as I go live with new inspiration and topics.// Want something more self-paced with access to weekly group support and getting coached by yours truly? Check out Freedom School – the community for ALL things related to freedom, inside and out. We dive into taking wisdom and applying it to our daily lives, with different topics every month. Learn more at JoinFreedomSchool.com. I can't wait to see you there!// Have you benefited from even one episode of the Rebel Buddhist Podcast? I'd love it if you could leave a 5-star review on iTunes by clicking here  or on Spotify by clicking here.

Timecodes: 0:00 Start 00:43 Secret Lives of Mormon Wives' Fruity Pebbles Rumor 15:05 Post KFC Radio Ending Announcement Thoughts 25:51 Funny weekend stories 42:43 Joe Budden Podcast "Shoutout" 45:37 Joe Budden Show KFC Radioi "Shoutout": https://open.spotify.com/episode/26q3wiSzxgD1GUpY37S0Uo 52:18 TV Recaps 01:30:46 Looking back on the start of KFC Radio +++++++++++++++++++++++++++++++++++++++++ Gametime: Download the Gametime app today and use code KFC for $20 off your first purchase Bluechew: Use promo code KFC at https://bluechew.com for your first month FREE Kraken: Kraken: Offer begins November 5th 18:00 UTC and ends December 3rd 23:59:59 UTC. Opt-in required via the Kraken app. One entry per $1 traded on Kraken. 1,000,000 entry cap per user. Geographic restrictions apply. Terms apply: https://kraken.com/legal/bitcoin-sweepstakes-terms. PHX: USE PROMO CODE BARSTOOL5 FOR $5 OFF YOUR ORDER AT DRINKPHX.COM Aura Frames: Exclusive $35 off Carver Mat at https://on.auraframes.com/KFC. Promo Code KFCYou can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/kfcr

Ukraine as Buffer State — Mary Kissel — Kissel articulates core U.S. strategic interests in Ukraine beyond ideological commitments: Ukraine's role as a critical geographic buffer against Russian expansion into Western Europeand its status as a major agricultural producer essential for global food security and economic stability. Kissel defends U.S. diplomatic engagement with Syrian leader Al-Sharaa, arguing that countering Russian regional influence in Syriajustifies negotiating with new Damascus authorities. Kissel expresses skepticism regarding whether Al-Sharaa will fulfill counter-terrorism commitments following receipt of U.S. sanctions relief, highlighting the perennial tension between incentivizing behavioral change and verification of compliance. 1854 ODESSA

Today, we'll be tackling the future of prostate cancer care. We'll be reflecting on what prostate cancer care means in practice, how the way we think about the disease is shifting, and must continue to shift in the years ahead. Scientific advances have transformed treatment in recent years, yet the lived reality of prostate cancer still extends far beyond the clinic. The disease reshapes daily life, and may leave men and their families grappling with difficult choices about how best to manage it.  Dr. Güneş Taylor is joined by three key voices at the centre of this story, following the prostate cancer journey from diagnosis through to long-term management, and asking how patients and clinicians can work together to re-think what patient-centred care could mean in the years to come. This episode is brought to you in collaboration with Bayer, part of their Prostate Cancer Perspectives series.  PP-UN-ONC-GB-0168. November 2025 References Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263 (Prostate cancer is the second most common cancer in men and the fifth leading cause of cancer death worldwide) James D, et al. The Lancet Commission on prostate cancer: planning for the surge in cases. Lancet. 2024;403(10437):1683–1722 (Each year, around 1.5 million men are diagnosed and nearly 400,000 lose their lives to the disease.1 And the numbers are rising. Diagnoses are projected to double from 1.4 million annually in 2020 to 2.9 million by 2040) Siegel RL, et al. Cancer statistics, 2022. Ca Cancer J Clin. 2022;72:7–33 (In the U.S., the proportion of men diagnosed with advanced-stage prostate cancer has doubled in recent years, due to increasing incidence of advanced-stage disease and changing guidelines regarding the prostate specific antigen screening test, implemented in the U.S. in 2012) Dodkins J, et al. Geographic, socioeconomic and demographic inequalities in the incidence of metastatic prostate cancer at time of diagnosis in England: a population based evaluation. BMJ Oncology. 2025;4:e000643 (In England, nearly one in five men only receive a diagnosis once their cancer has spread) Calvo-Schimmel A, et al. Supportive care interventions and quality of life in advanced disease prostate cancer survivors: An integrative review of the literature. Can Oncol Nurs J. 2021;31(4):412-429 (Advanced prostate cancer is often associated with long-term challenges leading to greater levels of unmet needs in supportive care) Learn more about your ad choices. Visit podcastchoices.com/adchoices

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The Multi-Geographic War on Drugs and Latin American Politics Guest: Professor Evan Ellis Professor Evan Ellis details the complex, multi-geographic war on drugs, noting the Department of Defense is leading strikes against designated terrorist groups, including Venezuela's Cartel de Los Soles. The deployment of the USS Gerald Ford Battle Group to the Caribbean raises speculation about potential land strikes against criminal leadership in Venezuela, though this carries considerable geopolitical risks. Ellis also discusses the surprising electoral success of Argentina's President Javier Milei, which strengthens the center-right political trend across Latin America.

The Multi-Geographic War on Drugs and Latin American Politics Guest: Professor Evan Ellis Professor Evan Ellis details the complex, multi-geographic war on drugs, noting the Department of Defense is leading strikes against designated terrorist groups, including Venezuela's Cartel de Los Soles. The deployment of the USS Gerald Ford Battle Group to the Caribbean raises speculation about potential land strikes against criminal leadership in Venezuela, though this carries considerable geopolitical risks. Ellis also discusses the surprising electoral success of Argentina's President Javier Milei, which strengthens the center-right political trend across Latin America. 1910 PERU