Podcasts about Clinical research

  Fertility Docs Uncensored is hosted by Dr. Carrie Bedient from the Fertility Center of Las Vegas, Dr. Susan Hudson from Texas Fertility Center, and Dr. Abby Eblen from Nashville Fertility Center. Today, they had a special Guest: Phillip Romanski, Associate Research Director of US Fertility. He is also an Assistant Professor and Associate Program Director of the reproductive endocrinology fellowship at Mount Sinai. In this episode, the docs explore how research shapes the future of fertility care. As Associate Research Director for US Fertility, Dr. Romanski shares how the organization leverages its extensive national data to support studies that directly influence patient outcomes. With eight to nine active clinical studies, patients can visit the US Fertility website to learn about current opportunities to participate, helping advance science, even if the immediate benefits are for future patients. Dr. Romanski highlights a recent study examining development in embryos that initially appeared to have abnormal fertilization. Surprisingly, many of these embryos progressed to the blastocyst stage, and a significant number were genetically normal. This information may help increase the number of viable embryos for future transfer. He also discusses a recent study with unexpected results: a comparison of fertilization outcomes between ICSI and conventional insemination with frozen sperm. Traditionally, eggs are fertilized with ICSI when using frozen sperm. By dividing eggs from individual patients and comparing ICSI with conventional insemination, the team found no difference in fertilization outcomes. This finding could reduce unnecessary embryo manipulation, minimize risk, and decrease costs for patients. This episode takes a fascinating look at how research today is improving the fertility treatments of tomorrow. This podcast was sponsored by US Fertility. 

“Study” that's not even a study spreads panic about dubious melatonin-heart failure link; Should you ignore dr's advice to take powerful acid-blocking drugs? Novel implantable electrical pacemakers may bring relief to sufferers of severe constipation; Benefits of cocoa flavanols for heart, brain, athletic performance. Give the gift of healthy chocolate! Go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide. Plus get free shipping on all orders over $30. 

Send us a textDr. Michael Koren joins Kevin Geddings to discuss some of the pitfalls of traditional healthcare in America and how clinical research can bridge those gaps. The doctor and clinical researcher talks about a family member recieving care in a world-class medical facility, and that even in this setting there is confusion about who is coordinating the patient's care. He contrasts this experience with clinical research, where there are fewer patients and protocol-specified individuals who are required to keep the patient front-of-mind and take charge of medical care.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Jaime's LinkedIn: https://www.linkedin.com/in/jaime-valles-2a1728221?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_appInato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein's role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers' advice to avoid fish oil. 

Join Dr. Michael Koren, CEO and Executive Director of MedEvidence, to explore how education and transparency can reshape the public's understanding of clinical research. Dr. Koren shares his passion for putting patient welfare first and highlights how Med Evidence empowers individuals to make informed decisions about participating in trials. He discusses the importance of building trust, breaking down misconceptions, and helping communities see research as a valuable care option. Tune in to discover how storytelling, visibility, and patient engagement are helping redefine the relationship between the public and clinical research.

Before every breakthrough in oncology, there's phase I research — where innovation, teamwork, and patient trust come together.In this episode, Dr. R. Donald Harvey, PharmD, BCOP, FCCP, FHOPA, FASCO, Vice President of Clinical Research and Executive Director of the Emory Clinical Research Office, joins hosts Ginger Blackmon, PharmD, and Maddy Floysand, PharmD, for an inside look at how early-phase clinical trials lay the groundwork for new cancer therapies.Dr. Harvey, also Professor of Hematology/Medical Oncology and Pharmacology and Associate Dean for Clinical Research at Emory University, shares how phase I studies are evolving to balance discovery, safety, and patient care while expanding access beyond academic centers.He talks about:How early-phase trials shape the future of oncology treatmentsCollaboration between academic and community sites to improve access and equityThe vital role of pharmacists in study design, safety, and educationHow AI and data are changing trial design and patient matchingAdvice for clinicians and students interested in research careersDr. Harvey also reflects on the teamwork that drives meaningful progress and what continues to inspire him after decades of leading research that connects science to patient impact.

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Today, we have with us the co-founders of the gut health company, Good Bacteria – CEO Anabel González and Chief Well-being Officer Leigh Frame, PhD, MHS. Misha: Anabel founded Good Bacteria to create science-backed solutions that connect whole foods with microbiome support. The company's main product is a 28-day rotating synbiotic, developed with Dr. Frame, that changes its probiotic strains, prebiotic fibers, and postbiotic weekly. Janette: Dr. Frame is a nutrition scientist and a recognized expert on Integrative Medicine, the gut microbiome, and the gut-brain axis. She's also the OIMH's executive director, associate professor in the departments of Clinical Research & Leadership and Physician Assistant Studies, co-director of the Frame-Corr Lab here at GW, and co-host of the GW Integrative Medicine podcast. Related Links Good Bacteria https://bit.ly/4hKANWL ◘ Transcript bit.ly/3JoA2mz ◘ This podcast features the song “Follow Your Dreams” (freemusicarchive.org/music/Scott_Ho…ur_Dreams_1918) by Scott Holmes, available under a Creative Commons Attribution-Noncommercial (01https://creativecommons.org/licenses/by-nc/4.0/) license. ◘ Disclaimer: The content and information shared in GW Integrative Medicine is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in GW Integrative Medicine represent the opinions of the host(s) and their guest(s). For medical advice, diagnosis, and/or treatment, please consult a medical professional.

Send us a textDr. Michael Koren joins Kevin Geddings to discuss the current state of COVID vaccines and research. The cardiologist weighs the real risks and benefits of COVID vaccines, focusing on who may need protection the most and who might be able to skip this year's booster. Dr. Koren also talks about the new prescription mandate for COVID vaccines, and how joining a clinical trial may help some people clear that burden more easily.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Daylight Savings Time changeover health myths busted; A doctor breaks her ankle and is billed $64,000 in uncovered expenses; Vitamin D shields life-prolonging telomeres, may help depression; The vaunted DASH Diet for hypertension faces off against low-carb alternative; The critical first 1000 days after conception—early life sugar avoidance yields major later life health dividends; Do you really need hot water to disinfect your hands?

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Exploring biomarker testing in clinical research

Welcome to Episode 279 of Autism Parenting Secrets.This week, I'm joined by Dr. Debby Hamilton, a pediatrician and functional medicine expert who specializes in supporting children with autism, ADHD, PANS/PANDAS, and other complex chronic conditions.She's the author of Preventing Autism and ADHD: Controlling Risk Factors Before, During, and After Pregnancy and currently serves as the Director of Product Education and Clinical Research at NutraMedix.On this podcast, we focus on uncovering the root causes that parents can address to help their child thrive. And in this episode, we dive into one of the most overlooked yet critical areas — mitochondrial dysfunction. When the body's energy production is compromised, kids can't run on all cylinders. Helping restore that energy at the cellular level can be a game-changer. The secret this week is…Address the ENERGY CRISIS You'll Discover:Why Mitochondrial Dysfunction Is So Common in Autism (3:16)Subtle Signs of Low Cellular Energy Parents Can Look For (5:45)How the OAT Test and MitoSwab Provide Useful Clues (14:34)Why Tylenol and Other Common Meds Damage Mitochondria (25:25)How Nutrition and Fats Support Brain Growth and Function (28:55)Why Protein and Fat at Every Meal Is Non-Negotiable (33:49)Why Recovery Is a Step-by-Step Journey, Not a Quick Fix (36:31)About Our Guest:Dr. Debby Hamilton is a pediatrician and functional medicine expert specializing in children with autism, ADHD, PANS/PANDAS, mood and behavioral issues, and other complex chronic conditions. She is the author of Preventing Autism and ADHD: Controlling Risk Factors Before, During & After Pregnancy and serves as the Director of Product Education and Clinical Research at NutraMedix. Dr. Hamilton has over two decades of experience helping families uncover and address root causes so kids can thrive.drdebbyhamilton.com | nutramedix.comReferences In This Episode:Preventing Autism and ADHD by Dr. Debby HamiltonAPS Episode 272 - AVOID THIS Popular Drug To Protect Development Additional Resources:To learn more about personalized 1:1 support, go to www.elevatehowyounavigate.comTake The Quiz: What's YOUR Top Autism Parenting Blindspot?If you enjoyed this episode, share it with your friends.

Dr Tom Russ narrates his blog written for Dementia Researcher. In this guest blog, Tom traces his path into clinical research, crediting the people who guided, inspired, and challenged him along the way. From his early days in psychiatry to leading national dementia research initiatives, he explores the lessons learned from mentors like Professor John Starr and others who shaped his academic and clinical outlook. The piece underscores the importance of supportive working cultures, mentorship, and the balance between independence and guidance in a research career. Find the original text, and narration here on our website. https://communities.dementiaresearcher.nihr.ac.uk/c/research-chat/when-i-think-about-how-i-got-into-clinical-da9b5827-eef3-4a06-ba3a-39cded10cc83 -- Dr Tom Russ is Reader in Old Age Psychiatry at The University of Edinburgh and Director of the Alzheimer Scotland Dementia Research Centre. His research spans clinical and interdisciplinary dementia studies. He works to improve understanding and care for people living with dementia and their families. -- Enjoy listening? We're always looking for new bloggers, drop us a line. http://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://x.com/demrescommunity https://bsky.app/profile/dementiaresearcher.bsky.social https://www.linkedin.com/company/dementia-researcher Join our community: https://onelink.to/dementiaresearcher

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Andrew Lee, Vice President, Clinical Research at Uniquity Bio, about Thymic Stromal Lymphopoietin (TSLP) and eosinophilic esophagitis (EOE). Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:49] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:13] Holly introduces today's topic, Thymic Stromal Lymphopoietin (TSLP) and eosinophilic esophagitis (EOE), and today's guest, Dr. Andrew Lee, Vice President, Clinical Research at Uniquity Bio.   [1:36] Dr. Lee has nearly 20 years of experience in the clinical development of new vaccines, biologics, and drugs. Holly welcomes Dr. Lee.   [1:52] Dr. Lee trained in internal medicine and infectious diseases.   [1:58] Dr. Lee has been fascinated by the immune system and how it can protect people against infections, what happens when immunity is damaged, as in HIV and AIDS, and how to apply that knowledge to boost immunity with vaccines to prevent infections.   [2:16] Dr. Lee led the clinical development for a pediatric combination vaccine for infants and toddlers. It is approved in the U.S. and the EU.   [2:29] Dr. Lee led the Phase 3 Program for a monoclonal antibody to prevent RSV, a serious infection in infants. That antibody was approved in June 2025 for use in the U.S.   [2:44] In his current company, Dr. Lee leads research into approaches to counteract an overactive immune system. They're looking at anti-inflammatory approaches to diseases like asthma, EoE, and COPD.   [2:58] Dr. Lee directs the ongoing Phase 2 studies that they are running in those areas.   [3:28] Dr. Lee sees drug development as a chance to apply cutting-edge research to benefit people. He trained at Bellevue Hospital in New York City in the 1990s.   [3:40] When Dr. Lee started as an intern, there were dedicated ICU wards for AIDS patients because many of the sickest patients were dying of AIDS and its complications.    [3:52] Before the end of Dr. Lee's residency, they shut down those wards because the patients were on anti-retroviral medications and were doing so well that they were treated as outpatients. They didn't need dedicated ICUs for AIDS patients anymore.   [4:09] For Dr. Lee, that was a powerful example of how pharmaceutical research and drug regimen can impact patients' lives for the better by following the science. That's what drove Dr. Lee to go in the direction of research.   [4:48] Dr. Lee explains Thymic Stromal Lymphopoietin (TSLP). TSLP serves as an alarm signal for Type 2 or TH2 inflammation, a branch of the immune responses responsible for allergic responses and also immunity against parasites.   [5:17] When the cells that line the GI tract and the cells that line the airways in our lungs receive an insult or an injury, they get a danger signal, then they make TSLP.   [5:28] This signal activates other immune cells, like eosinophils and dendritic cells, which make other inflammatory signals or cytokines like IL-4, IL-13, and IL-5.   [5:47] That cascade leads to inflammation, which is designed to protect the body in response to the danger signal, but in some diseases, when there's continued exposure to allergens or irritants, that inflammation goes from being protective to being harmful.   [6:15] That continued inflammation, over the years, can lead to things like the thickened esophagus with EoE, or lungs that are less pliant and less able to expand, in respiratory diseases.   [6:48] Dr. Lee says he thinks of TSLP as being a master switch for this branch of immune responses. If you turn on TSLP, that turns on a lot of steps that lead to generating an allergic type of response.   [7:06] It's also the same type of immune response that can fight off parasite infections. It's the first step in a cascade of other steps generating that type of immune response.   [7:30] Dr. Lee says people have natural genetic variation in the genes that incur TSLP.   [7:38] Observational studies have found that some people with genetic variations that lead to higher levels of TSLP in their bodies had an increased risk for allergic inflammatory diseases like EoE, atopic dermatitis, and asthma.   [8:13] Studies like the one just mentioned point to TSLP being important for increased risk of developing atopic types of diseases like EoE and others. There's been some work done in the laboratory that shows that TSLP is important for activating eosinophils.    [8:38] There's accumulating evidence that TSLP activation leads to eosinophil activation, other immune cells, or white blood cells getting activated.   [9:07] Like a cascade, those cells turn on T-cells and B-cells, which are like vector cells. They lead to direct responses to fight off infections, in case that's the signal that leads to the turning on TSLP.   [9:48] Ryan refers to a paper published in the American Journal of Gastroenterology exploring the role of TSLP in an experimental mouse model of eosinophilic esophagitis. Ryan asks what the researchers were aiming to find.   [10:00] Dr. Lee says the researchers were looking at the genetic studies we talked about, the observational studies that are beginning to link more TSLP with more risk for EoE and those types of diseases.   [10:12] The other type of evidence that's accumulating is from in vitro (in glass) experiments or test tube experiments, where you take a couple of cells that you think are relevant to what's going on.   [10:28] For example, you could get some esophageal cells and a couple of immune cells, and put TSLP into the mix, and you see that TSLP leads to activation of those immune cells and that leads to some effects on the esophageal cells.   [10:42] Those are nice studies, but they're very simplified compared to what you can do in the body. These researchers were interested in extending those initial observations from other studies, but working in the more realistic situation of a mouse model.   [11:00] You have the whole body of the mouse being involved. You can explore what TSLP is doing and model a disease that closely mimics what's happening with EoE in humans.   [12:23] They recreated the situation of what seems to be happening in EoE in people. We haven't identified it specifically, but there's some sort of food allergen in patients with EoE that the immune system is set off by.   [12:55] What researchers are observing in this paper is that in these mice that were treated with oxazolone, there is inflammation in the esophagus, an increase in TSLP levels, and eosinophils going into the esophageal tissues.   [13:15] Dr. Lee says, that's one of the main ways we diagnose EoE; we take a biopsy of the esophagus and count how many eosinophils there are. Researchers saw similar findings. The eosinophil count in the esophageal tissues went way up in these mice.    [13:34] Researchers also saw other findings in these mice that are very similar to EoE in humans, such as the esophageal cells lining the esophagus proliferating. They even saw that new blood vessels were being created in that tissue that's getting inflamed.   [14:00] Dr. Lee thinks it's a very nice paper because it shows that correlation: Increase TSLP and you see these eosinophils going to the esophagus, and these changes that are very reminiscent of what we see in people with EoE.   [14:51] In this paper, the mice made the TSLP, and researchers were able to measure the TSLP in the esophageal tissue. The researchers didn't introduce TSLP into the mice. The mice made the TSLP in response to being repeatedly exposed to oxazolone.   [15:20] That's key to the importance of the laboratory work. The fact that the TSLP is made by the mice is important. It makes it a very realistic model for what we're seeing in people.   [15:41] In science, we like to see correlation. The researchers showed a nice correlation.   [15:46] When TSLP went up in these mice, and the mice were making more TSLP on their own, at the same time, they saw all these changes in the esophagus that look a lot like what EoE looks like in people.    [16:01] They saw the eosinophils coming into the esophagus. They saw the inflammation go up in the esophagus. What Dr. Lee liked about this paper is that they continued the story.   [16:15] The researchers took something that decreases TSLP levels, an antibody that binds to and blocks TSLP, and when they did that, they saw the TSLP levels come down to half the peak level.   [16:35] Then they saw improvement in the inflammation in the esophagus. They saw that the amount of eosinophils decreased, and the multiplication of the esophageal cells went down. The number of new blood vessels went down after the TSLP was reduced.   [16:53] Dr. Lee says, you see correlation. The second part is evidence for causation. When you take TSLP away, things get better. That gives us a lot of confidence that this is a real finding. It's not just observational. There is causation evidence here.   [18:26] Ryan asks if cutting TSLP also help reduce other immune response cells. Dr. Lee says TSLP is the master regulator for this Type 2 inflammation. It definitely touches and influences other cells besides eosinophils.   [18:44] TSLP affects dendritic cells, which are an important type of immune cell, like a coordinating cell that instructs other cells within the immune system what to do. In this paper, they looked at a lot of other effects of TSLP on the tissues of the body.   [19:10] Dr. Lee says, There's a lot of research on TSLP, and one of the reasons we're excited about the promise of TSLP is that it's so far upstream; so much of the beginning, that it's affecting other cells.   [19:29] Its effects could be quite broad. If we're able to successfully block TSLP, we could block a lot of different effects.   [19:40] One treatment for EoE is dupilumab, which blocks IL-4 and IL-13 specifically, and that works well, but TSLP has the potential to have an even greater effect than blocking IL-4 and IL-13, since it is one step before turning on IL-4 and IL-13.    [20:14] That's one of the reasons researchers are excited about the promise of blocking TSLP. There are studies ongoing of TSLP blockers in people with EoE.   [20:34] Ryan asks if there are negative repercussions from blocking TSLP. Dr. Lee says in this study and in people, we are not completely blocking TSLP by any means. There will still be residual TSLP activated, even with very potent drugs.   [21:01] In the study, they block TSLP about 50%‒60%. TSLP is involved in immunity against parasites. In studies with people, they make sure not to include anybody who has an active parasitic infection. A person under treatment should not be in a study.   [21:27] Dr. Lee says we haven't seen any problems with parasitic infections becoming more severe, but that is a theoretical possibility, so for that reason, in studies with TSLP blockers, we generally exclude patients with known parasitic infections.   [22:17] What excited Dr. Lee in this paper was that they showed that when you block TSLP in the mice, then you get real effects in their tissues. Eosinophils went away. The thickening of the basal layers in the esophagus got much better.   [22:38] That kind of real effect reflected in the tissue is super exciting to see. That gives us more confidence that this could work in people, since we're seeing it in a realistic whole-body model in the mice.   [23:12] Dr. Lee says there are ongoing clinical studies on TSLP blockers for EoE. His company is studying an antibody that blocks TSLP in eczema, COPD, and EoE. One of the exciting things about immunology is that it affects many different parts of the body.   [23:42] EoE is associated with other immune-type disorders. There's a high percentage of patients with EoE who have other diseases. EoE coexists with asthma, atopic dermatitis, and chronic rhinitis.   [24:09] It's exciting that if you figure out something that's promising for one disease that TSLP affects, it could have very broad-ranging implications for a variety of diseases.   [24:22] Ryan shares his experience of his doctor talking to him about a TSLP blocker, tezepelumab, as a potential option when it's out of clinical trials. It would target something a little higher up the chain and help with some of his remaining symptoms.   [24:59] Ryan is excited to hear that this research is so encouraging and how it could potentially help treat EoE, asthma, and other conditions, all at once.   [25:16] Dr. Lee says that being in these later-stage studies is super exciting. If these late-stage trials are successful, the next step is to apply for regulatory approval with the various agencies around the world.   [26:40] Dr. Lee shares one takeaway for listeners to remember. Think of TSLP as an alarm that turns on inflammation. He compares TSLP to turning on an alarm during a robbery. There are multiple steps designed to protect the bank and the money.   [27:20] To extend that analogy, with TSLP, once you turn it on, all these other steps are going to happen. Inflammation is designed to protect the body. It's a protective response. If there's an infection, it can clear the infection.   [27:38] If the infection persists, as in HIV, the immune response, which is protective and beneficial, eventually becomes damaging. It becomes dysfunctional. In EoE, if you continually eat the allergic food, the inflammation becomes damaging to the esophagus.   [28:27] Long-term inflammation leads to replacing the normal esophageal tissue with fibrotic tissue, and that's why the esophagus eventually gets hardened and less able to let the food go through.   [28:40] In respiratory diseases, the soft tissue of the lung gets replaced with thicker tissue, and the lung is not able to expand.   [28:54] Dr. Lee says he people to think about TSLP as this master alarm switch. We hope that if you could turn off that TSLP, you could then avoid a lot of the complications that we see with chronic inflammation in these conditions.   [29:14] We're hopeful that you could even take away the symptoms that you see in these diseases, make patients feel better, and with extended treatment, you could begin to reverse some of the damage resulting from inflammation.   [29:32] Ryan likes that analogy and how Dr. Lee has concisely explained these complicated concepts.   [29:51] Dr. Lee thanks Holly and Ryan and adds one more plea to listeners. Please consider getting involved with research. Clinical trials cannot be done without patients. We need patients to advance new treatments.   [30:27] Researchers like Dr. Lee spend a lot of time thinking about how to make the studies not only informative but also fair to patients who decide to become involved. It's a lot of work and a fair amount of time commitment.   [30:44] If you don't want to be in a study, you can help by being on a patient feedback panel and reviewing protocols and informed consents. Follow your interests. Think about getting involved with research, however you can.   [31:06] Ryan and Holly are very grateful for the community, with so many wonderful clinicians and researchers, and so many patients who are willing to volunteer their time and their data to help researchers find better solutions going forward.   [31:26] Ryan thanks Dr. Lee for coming on and putting out that call to action. It's a great reminder for listeners and the patients in the community to look for those opportunities. Chat with your physician. Go to APFED's website. There's a link to active clinical trials.   [31:47] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes below.   [31:53] For those looking to find specialists who treat eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist.   [32:01] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [32:11] Ryan thanks Dr. Andrew Lee for joining us today. We learned a lot. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Andrew Lee, M.D., VP Clinical Research, Uniquity Bio   "A Mouse Model for Eosinophilic Esophagitis (EoE)" Current Protocols, Wiley Online Library   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   "I see drug development as a chance to apply cutting-edge research to benefit people." — Andrew Lee, M.D.   "When the cells that line the GI tract and the cells that line the airways in our lungs receive an insult or an injury, they get a danger signal, then they make TSLP." — Andrew Lee, M.D.   "Observational studies have found that some people with genetic variations that lead to higher levels of TSLP in their bodies had an increased risk for allergic inflammatory diseases like EoE, atopic dermatitis, and asthma." — Andrew Lee, M.D.   "There's a lot of research on TSLP, and one of the reasons we're excited about the promise of TSLP is that it's so far upstream; so much of the beginning, that it's affecting other cells." — Andrew Lee, M.D.   "Please consider getting involved with research. We can't do these clinical trials without patients. We need patients to advance new treatments for patients." — Andrew Lee, M.D.

Are you ready to challenge the myths of aging and discover how to stay strong, vital, and resilient for decades to come? In this episode of the Thyroid Answers Podcast, Dr. Eric Balcavage sits down with Dr. Mani Kukreja to explore the cutting-edge science of healthy aging. We dive into: Why aging is not just about years—but about cellular health and resilience The hidden role of thyroid physiology in longevity and vitality Nutrition, movement, and lifestyle strategies that slow the aging clock The difference between simply "managing" disease and truly recovering health Practical steps you can take now to age stronger and live longer And more ... This episode is packed with valuable insights for anyone seeking to protect their thyroid, boost energy, and thrive throughout midlife and beyond. Dr. Mani Kukreja is a medically trained wellness advocate and the founder of LivAgeWell, a comprehensive wellness platform dedicated to optimizing health and preventing disease. With a background in medicine and a Master of Public Health in Clinical Research from Tulane University, Dr. Kukreja combines her extensive medical training with cutting-edge wellness strategies. Her career spans leadership roles at the University of Alabama at Birmingham's Cardiovascular Surgical Research Program and the Medical College of Wisconsin Cancer Research Program, where she directed clinical research operations. She is a sought-after keynote speaker and educator, recognized for her expertise in health optimization, biohacking, and disease prevention. Her holistic approach integrates evidence-based medicine with nutritional science and lifestyle modifications. Featured in Authority Magazine, The Daily Star, Grit Daily, and other leading publications, Dr. Kukreja is an entrepreneur, author, and thought leader who is transforming lives by making personalized wellness accessible to all. She empowers women to take control of their health through science-backed lifestyle changes. Dr Mani's contact information: https://manikukreja.com/ https://www.instagram.com/dr.mani.kukreja/

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

2025-10-24 Hosts Amir Kalali, Craig Lipset, and Jane Myles were joined by Darshan Kulkarni, a pharmacist, lawyer, and educator, for a fantastic conversation around the intersection of healthcare innovation, regulatory law, and emerging technologies. Listeners will learn more on:Challenges in AI protocol protection and data privacy under HIPAA, GDPR, and global lawsThe tension between innovation and compliance in decentralized trialsThe importance of clear regulatory guidance in the evolving AI landscapeHow contractual and ethical frameworks can safeguard both sponsors and sitesYou can join TGIF-DTRA Sessions live on LinkedIn Live on Friday's at 12:00 PM ET by checking out our LinkedIn. Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

Saturday, October 25, 2025. Week 43.   Time to advocate, ELF on the Hill, support available, apply now: https://www.linkedin.com/posts/everylifeorg_were-excited-to-join-everyone-on-capitol-activity-7384625926333943808-mO1U/   PUBMED at 47, and low. Clinical research! https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2025-2025&sort=date   - CHOP EEG ProMMiS ​​https://www.neurology.org/doi/10.1212/WNL.0000000000214148?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed - COMMUNICATION #ORCA https://acamh.onlinelibrary.wiley.com/doi/full/10.1111/jcpp.70063   Doing surveys gets us into papers like ORCA, helps us raise awareness of SRD.  This one on AI is really interesting: https://redcap.tch.harvard.edu/redcap_edc/surveys/?s=YFHYH7T7LTPAL44X   Newsletter #47 https://mailchi.mp/curesyngap1.org/unlock-their-tomorrow-issue47    IPM on SRD AAV https://www.insideprecisionmedicine.com/topics/precision-medicine/gene-therapy-reverses-syngap1-brain-disorder-symptoms-in-mice/   NYT Take on #Autism is very good, thank you Azeen Ghorayshi Split the Autism Spectrum: https://www.nytimes.com/2025/10/01/health/autism-spectrum-neurodiversity-kennedy.html?unlocked_article_code=1.q08.NXEA.fg5ulHeTHUeJ&smid=url-share quotes Jackie K, explores argument for Profound & Severe Autism as a category.    Our own Jackie Kancir has a great substack, listen to it in her voice here: https://jkancir.substack.com/p/autism-is-not-my-daughter-nor-her   Tylenol: https://www.nytimes.com/video/science/100000010414944/trump-pushes-unproven-link-between-tylenol-and-autism.html   Sign up for Citizen Health: https://www.citizen.health/partners/srf   CURE SYNGAP1 Conference 2025 Atlanta: https://curesyngap1.org/events/conferences/cure-syngap1-conference-2025-hosted-by-srf/   USE YOUR ICD-10 F78.A1 #S10e185 https://www.youtube.com/watch?v=dale0NbxDpU   SOCIALS 4,417 LinkedIn.  https://www.linkedin.com/company/curesyngap1/  1,470 YouTube.  https://www.youtube.com/@CureSYNGAP1    11k Twitter https://twitter.com/cureSYNGAP1  45k Insta https://www.instagram.com/curesyngap1/    Episode 187 of #Syngap10 #CureSYNGAP1

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Send us a textDr. Michael Koren joins Kevin Geddings to discuss advances in brain imaging technology. The doctor opens with a fun story about a breakup in college, then moves to discuss how brain imaging for Alzheimer's may move from noisy tunnels to a dentist-chair-like apparatus for easier scanning in a smaller space. The duo brings it together with the benefits of clinical research and how those who participate may get access to the newest technologies.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Examining the claim that cabbage family vegetables are bad for the thyroid; Walmart announces sweeping move to reformulate its products without synthetic dyes, sketchy additives; Under Congressional questioning, Google admits to censoring contrary narratives on YouTube during Covid; Children garner psychological benefits from grandparent time; J&J fined nearly $1 billion in landmark talc baby powder lawsuit; Humans are among the few animals who can't make their own vitamin C—why that may be a good thing.

In this episode Ben Plumley catches up with Dr. Seth Berkley, founder of the International AIDS Vaccine Initiative, former CEO of GAVI and amongst other responsibilities, now a senior advisor at Brown University's School of Public Health's Pandemic Center. Seth has recently published a new book “Fair Doses: An Insider's Story of the Pandemic and the Global Fight for Vaccine Equity” and he and Ben discuss the book's topics of vaccine equity, misinformation, and the rapid innovations in vaccine development, particularly the success and future potential of mRNA vaccines. Dr. Berkley highlights the challenges posed by misinformation and the political landscape, as well as the importance of global collaboration in addressing pandemics. They also explore his defining role in Covax's efforts to distribute COVID vaccines, the need for local manufacturing, and the impacts of nationalistic policies on global health. Dr. Berkley stresses the critical role of ongoing innovation and funding in preparing for future health crises and ensuring equitable access to health technologies. And he pulls no punches on the current US administration's failures in supporting global health research and partnerships. https://www.ucpress.edu/books/fair-doses/hardcover 00:00 Introduction and Guest Introduction 01:05 Current State of Misinformation and Disinformation 03:56 Challenges in Public Health Communication 09:19 Reflections on COVID-19 and Vaccine Equity 12:44 Global Health and Future Pandemics 16:41 Vaccine Nationalism and Local Manufacturing 23:38 Preparedness for Future Health Threats 31:01 The Future of Clinical Research and Innovation 36:03 Seth Berkeley's Current Work and Future Plans 38:13 Conclusion and Closing Remarks Join the Conversation! How do you see the future of global health unfolding? Share your thoughts in the comments! Read Emily Bass' Substack: https://substack.com/@emilysbass Check Out Ben's Substack: https://substack.com/@benplumley1 Subscribe & Stay Updated: Listen on Spotify, Apple Podcasts, or your favorite podcast platform. Watch on YouTube & subscribe for more in-depth global health.

If you're enjoying the content, please like, subscribe, and comment! Dr. Schwartz's Links: Website: https://www.theodorehschwartzmd.com/ Book: https://www.penguinrandomhouse.com/books/734286/gray-matters-by-theodore-h-schwartz/ Theodore H. Schwartz, MD graduated Magna Cum Laude in Philosophy and English from Harvard University and Magna Cum Laude in Neuroscience from Harvard Medical School. After completing his residency and chief residency in Neurosurgery at The Neurological Institute of New York at Columbia-Presbyterian Medical Center, Dr. Schwartz spent a year at Yale-New Haven Medical Center where he received advanced fellowship training in epilepsy and brain tumor surgery. He completed a post-doctoral fellowship at the Max Planck Institute in Munich, Germany funded by the Van Wagenen Fellowship and the Von Humboldt Society. Dr. Schwartz spent 25 years as a Professor of Neurosurgery, Otolaryngology, and Neuroscience at Weill Cornell Medical College, New York Presbyterian Hospital. He was named David and Ursel Barnes Professor in Minimally Invasive Surgery, the first endowed professorship in the department, Vice-Chairman of Clinical Research, the Director of Anterior Skull Base and Pituitary Surgery, Co-Director of Surgical Neuro-Oncology, the Director of Epilepsy Surgery, and ran a basic science laboratory investigating the causes and treatment for epilepsy. He has received K08, R01 and R21 funding from the NINDS for his research and has served on several NIH review committees.Dr. Schwartz's book Gray Matters: A Biography of Brain Surgery, published by Dutton/Penguin-Random House, was selected by The Economist as one of the best books of 2024. His nonfiction writing has been featured in the Wall Steet Journal, the Boston Globe, Psyche Magazine, and The Psychologist. Dr. Schwartz is currently the Founder and CEO of a med tech device company called illumination Diagnostics._______________________Follow us!@worldxppodcast Instagram - https://bit.ly/3eoBwyr@worldxppodcast Twitter - https://bit.ly/2Oa7BzmSpotify - http://spoti.fi/3sZAUTGYouTube - http://bit.ly/3rxDvUL#neuroscience #surgeon #medschool #medical #neurosurgeon #surgery #medicine #medicalstudent #cte #tbi #trauma #traumaticbraininjury #concussion #subscribe #explore #explorepage #podcastshow #longformpodcast #podcasts #podcaster #podcasting #worldxppodcast #viralvideo #youtubeshorts

In this episode of WCG Talks Trials, Sandy Smith, Sylvia Baedorf Kassis, and Dr. Donna Snyder discuss the critical role of health literacy in clinical research. They explore how clear communication can enhance patient understanding and engagement, the importance of a common language in research, and the introduction of the MRCT Center's Clinical Research Glossary as a tool to facilitate better communication. The conversation emphasizes the need for consistent terminology and the integration of health literacy practices in clinical research to improve participant experiences and outcomes.Key highlights:Health literacy is crucial for effective communication and participant engagement in clinical research.The MRCT Center's Clinical Research Glossary helps simplify complex terms into plain language, supporting understanding for all stakeholders.Consistent terminology and clear communication empower participants, improve data accuracy, and enhance patient advocacy.Integrating health literacy practices leads to better retention and experiences for trial participants.Host:Sandy Smith, RN, MSN, AOCN, senior vice president, clinical solutions & strategic partnering, WCGGuests:Sylvia Baedorf Kassis, MPH, program director, Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and HarvardDonna Snyder, MD, MBE, executive physician, WCG

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Inato: https://go.inato.com/3VnSro6CRIO: http://www.clinicalresearch.ioMy PatientACE recruitment company: https://patientace.com/Join me at my conference! http://www.saveoursites.comText Me: (949) 415-6256Listen on Spotify: https://open.spotify.com/show/7JF6FNvoLnBpfIrLNCcg7aGET THE BOOK! https://www.amazon.com/Comprehensive-Guide-Clinical-Research-Practical/dp/1090349521/ref=sr_1_1?keywords=Dan+Sfera&qid=1691974540&s=audible&sr=1-1-catcorrText "guru" to 855-942-5288 to join VIP list!My blog: http://www.TheClinicalTrialsGuru.comMy CRO and Site Network: http://www.DSCScro.comMy CRA Academy: http://www.TheCRAacademy.comMy CRC Academy: http://www.TheCRCacademy.comLatinos In Clinical Research: http://www.LatinosinClinicalResearch.comThe University Of Clinical Research: https://www.theuniversityofclinicalresearch.com/My TikTok: DanSfera

Dr. Hoffman continues his conversation with Dr. Julie Faitg, a mitochondrial biologist and senior manager of Applied Research and Regulatory Affairs at Timeline. 

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman delves into the critical role of mitochondria in overall health with a particular emphasis on skincare with Dr. Julie Faitg, a mitochondrial biologist and senior manager of Applied Research and Regulatory Affairs at Timeline. The discussion highlights the broad impacts of mitochondrial health on lifestyle, diet, sleep, exercise, and psychological well-being. Focusing specifically on Urolithin A (MitoPure), they explore its promising benefits for muscle strength, endurance, and skin health through cellular renewal processes like mitophagy. Dr. Faitg emphasizes the clean formulation and clinical effectiveness of Timeline's various supplements and skincare products, underscoring their role in extending healthspan and rejuvenating skin from the outside in. The episode provides practical insights on product usage and the broader implications of mitochondrial science for anti-aging and wellness.

In this episode, host Jeremy Schrand is joined by Tim Schroeder, Chairman, CEO, and Founder of CTI, and Joel White, Owner of Marketcap Consulting, for a broad discussion on the clinical research industry. Topics include recent industry developments, biotech funding challenges, leadership in clinical trials, corporate citizenship, and predictions for future innovation.01:20 Tim shares insights on the current state ofthe clinical research industry, highlighting recent developments and a view toward stability and cautious optimism.02:36 Joe discusses macro trends shaping the clinical research landscape, focusing on biotech funding challenges and the impact on the industry.04:05 The conversation shifts to the pharma services sector, with Joe reflecting on the changing number of public companies and the influence of major investment firms.06:53 The conversation explores industry cancellation rates and repeat business, leading to a discussion on measurement differences and the challenges of consistent reporting.08:08 The role of leadership in navigating today's complex clinical trial environment is explored, emphasizing vision, talent retention, and cultural impact.13:08 Tim and Joel discuss corporate citizenship, leading to reflections on CTI's evolution, community involvement, and the importance of sustainability.21:01 Exploring the potential influence of major retail companies on the clinical trial ecosphere, the conversation considers their resources and the challenges they face within the industry.22:34 Tim addresses therapeutic areas with recent surges in activity or innovation, prompting a discussion on oncology,neurodegeneration, and GLP therapies.29:00 Bold predictions shape the future of the clinical research industry, with forecasts pointing to a recovery in biotech funding and shifts in FDA approval processes.

On this episode of JHLT: The Podcast, the Digital Media Editors invite author Dr. Ayumi Goda, from the Kyorin University Hospital in Tokyo, Japan, to discuss her team's paper, “Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension.” The discussion explores: How clinical observations led to the idea for a study on whether the passive leg raise could unmask occult HFpEF The potential diagnostic value of the passive leg raise in differing patient populations Age-specific cutoffs that may influence what kind of testing to use in clinical practice For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt. Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

Episode SummaryAI is everywhere — from apps on our phones to tools shaping clinical care. But what does it really mean for women's health? Could AI finally close the health gap — or will it reinforce the same frustrations women already face in the doctor's office?In this episode of Fempower Health, Georgie Kovacs sits down with Dr. Nikita Patel, a pharmacist, biomedical engineer, and healthcare innovation leader with 15 years of experience across biopharma, digital health, and AI. Nikita has held leadership roles including Director of Clinical Research & AI at Function Health, and she brings a multidisciplinary perspective on how data, diagnostics, and emerging technologies can transform health and human performance.Together, Georgie and Niki unpack what's misunderstood about AI in healthcare, why women's health needs its own data lens, and how clinicians and patients alike can use AI responsibly today.Discussion PointsWhat is AI in healthcare really doing behind the buzzword?Why is women's health data missing — and how does this bias impact AI tools?How can women use AI to better advocate for themselves in doctor visits?Can AI improve clinical trials and drug development for women?What privacy risks should women and clinicians know about when using AI apps?How can healthcare providers evaluate whether an “AI-powered” tool is credible?What's the future of personalized care — could digital twins and AI change everything?Who is responsible for setting standards for AI in women's health?

Rare diseases do not receive enough attention for the impact they have on patients and their families. This is what AlphaRose's founder and CEO Casey McPherson learned after his daughter was diagnosed with a rare condition. In a conversation with host Ari Berman, McPherson shares how he switched from music to founding his own pharmaceutical company, what technologies AlphaRose is developing, and how his company is creating environments that allow innovation and iteration. He also shares his thoughts on embracing failure in order to make progress and emphasizes holding compassion and understanding for the patients and families that are impacted by rare diseases—because you never know what it's like until it happens to you. Bio-IT World's Trends from the Trenches podcast delivers your insider's look at the science, technology, and executive trends driving the life sciences through conversations with industry leaders.

FDA announces crackdown on misleading TV drug ads, influencers, online drug dispensaries; What's a “twisted colon”? Doctors often jump the gun in prescribing ADHD meds to young kids before behavioral fixes; A new era in skincare powered by urolithin A.

Episode 198: In this episode of the Inform Performance Podcast, Andy McDonald is joined by Jeff Riepe, a distinguished expert at the intersection of sports science, rehabilitation, and human performance. Riepe earned his Doctorate in Physical Therapy from the University of Southern California, followed by a fellowship in Clinical & Sports Biomechanics at the Movement Performance Institute under the mentorship of Chris Powers. His career spans elite sports medicine roles with the NFL's Minnesota Vikings and Los Angeles Rams, numerous collegiate athletic programs, and the EXOS NFL Combine Training Program. Specializing in advanced movement analysis, Riepe integrates cutting-edge technologies such as 2D and 3D high-speed motion capture, force plate analysis, and wireless electromyography (EMG) to optimize rehabilitation and performance outcomes. Topics Discussed: MoveLab's Advanced Biomechanics Lab Data-Driven Rehabilitation Strategies Integration of Clinical Research and Normative Data Challenges in Late-Stage Rehabilitation The Role of VO₂ Max - Where you can find Jeff Riepe: LinkedIn Move Lab Instagram X -  Sponsors VALD Performance, makers of the Nordbord, Forceframe, ForeDecks and HumanTrak. VALD Performance systems are built with the high-performance practitioner in mind, translating traditionally lab-based technologies into engaging, quick, easy-to-use tools for daily testing, monitoring and training Hytro: The world's leading Blood Flow Restriction (BFR) wearable, designed to accelerate recovery and maximise athletic potential using Hytro BFR for Professional Sport.  -  Where to Find Us Keep up to date with everything that is going on with the podcast by following Inform Performance on: Instagram Twitter Our Website - Our Team Andy McDonald Ben Ashworth Alistair McKenzie Dylan Carmody Steve Barrett  Pete McKnight

On Episode #181 of the PricePlow Podcast, we sit down with twin brothers Ryan Gardner (CEO) and Jeff Gardner (CMO) of Bucked Up at their Salt Lake City headquarters. This conversation reveals the remarkable journey from internet marketing pioneers to building a billion dollar million supplement empire, complete with helicopter rides over Utah's mountains and an inside look at their massive manufacturing facility. The Gardner brothers share their incredible origin story that began with exact match domains and affiliate networks in the early 2000s, leading to a deer antler spray windfall thanks to Ray Lewis's Super Bowl controversy in 2013. From those humble beginnings, they built Bucked Up into the #1 pre-workout at GNC and Vitamin Shoppe, pioneered micro-influencer marketing before it was cool, and recently expanded into energy drinks with major partnerships including SoFi Stadium in Los Angeles -- all in pursuit of their "billion or bust" vision. Celebrating the Launch of Bucked Up Black Ant This episode also features the exclusive launch details of Black Ant, their revolutionary new pre-workout Mike and Ben helped formulate, featuring industry-first ingredients like RipFACTOR and Creasol SSAT alongside traditional creatine monohydrate (Black Ant is Bucked Up's first creatine-based pre-workout). The conversation explores everything from their innovative protein drinks with light carbonation to their thoughts on peptides, healthspan optimization, and the future of the supplement industry. https://blog.priceplow.com/podcast/bucked-up-ryan-jeff-gardner-181 Video: Inside Bucked Up HQ with the Gardner Brothers https://www.youtube.com/watch?v=MzGuzuGtuWQ Detailed Show Notes: From Internet Marketing to Supplement Empire (0:00) – Introductions: Meeting the Twin CEOs in Salt Lake City (2:15) – The Internet Marketing Origins: Early 2000s Digital Pioneers (6:30) – The L-Arginine Domain Score: Learning the Power of Exact Match Domains (9:45) – The Ray Lewis Windfall: Deer Antler Spray Goes Viral (14:30) – Entering the Pre-Workout Market: Innovation Through Transparency (20:45) – Micro-Influencer Marketing: Ahead of the Curve (24:45) – Dominating Retail: The Path to #1 at GNC and Vitamin Shoppe (28:00) – The Beverage Evolution: Learning Distribution Networks (31:30) – The Brand Beyond Products: Culture and Community (34:00) – Product Innovation Partnership: The Black Ant Story (38:00) – Revolutionary Strength Ingredients: RipFACTOR and Clinical Research (42:30) – Premium Positioning and Market Strategy (45:30) – Diversified Pre-Workout Portfolio Strategy (48:30) – Ready-to-Drink Pre-Workout Development (54:30) – Protein Innovation: Light Carbonation Revolution (58:45) – Protein Dosing Philosophy and Market Positioning (1:06:30) – Celebrity Partnerships and Brand Building (1:10:30) – Market Expansion and Penetration Strategy (1:12:30) – Peptides and Future Health Optimization (1:17:30) – Healthspan vs Lifespan Philosophy Where to Follow Bucked Up and Connect Ryan Gardner: LinkedIn&... Read more on the PricePlow Blog

Brain-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels originate from the cardiac cells in response to cardiac strain. This may come from a pulmonary embolus, an acute severe infection (sepsis), or cardiomyopathy. But what is the relationship between these 2 cardiac biomarkers and preeclampsia? Can preeclampsia with severe features result in an abnormal rise in these 2 proteins exclusive to heart failure. Listen in to this real case scenario which our on call team cared for. 1. Serum Levels of N-Terminal Pro-Brain Natriuretic Peptide in Gestational Hypertension, Mild Preeclampsia, and Severe Preeclampsia: A Study From a Center in Zhejiang Province, China. Zheng Z, Lin X, Cheng X. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2022;28:e934285. doi:10.12659/MSM.934285.2.Evaluation of B-Type Natriuretic Peptide (BNP) Levels in Normal and Preeclamptic Women. Resnik JL, Hong C, Resnik R, et al. American Journal of Obstetrics and Gynecology. 2005;193(2):450-4. doi:10.1016/j.ajog.2004.12.006.3.Increased B-Type Natriuretic Peptide Levels in Early-Onset Versus Late-Onset Preeclampsia. Szabó G, Molvarec A, Nagy B, Rigó J. Clinical Chemistry and Laboratory Medicine. 2014;52(2):281-8. doi:10.1515/cclm-2013-0307.4. Association of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension.5. Hauspurg A, Marsh DJ, McNeil RB, et al. JAMA logoJAMA Cardiology. 2022;7(3):268-276. doi:10.1001/jamacardio.2021.5617.STRONG COFFEE PROMO: 20% Off Strong Coffee Companyhttps://strongcoffeecompany.com/discount/CHAPANOSPINOBG

Send us a textIn this episode of At the Bench, hosts Dr. Misty Good and Dr. Betsy Crouch sit down with Dr. AnneMarie Stroustrup, Chair of Pediatrics at Zucker School of Medicine, Physician-in-Chief at Cohen Children's Medical Center, and senior vice president of the pediatric service line at Northwell Health.Dr. Stroustrup reflects on her path from early work in biotechnology to training as a neonatologist and physician scientist. She shares how volunteer experiences in an under-resourced emergency department shaped her decision to pursue medicine, and how her MPH in epidemiology provided the tools to investigate critical questions about fetal and neonatal exposures.The conversation highlights her research on environmental chemicals—particularly phthalates—and their links to outcomes such as bronchopulmonary dysplasia, work within the NIH ECHO program, and the importance of large-scale, collaborative science. Dr. Stroustrup also discusses the persistence required in research, navigating funding rejections, and translating epidemiologic findings back to bench models.The discussion concludes with her insights on leadership in neonatology, from directing divisions and fellowships to now serving as chair, balancing research, clinical duties, and family life while advocating for sustainable staffing models in pediatrics.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this episode of the Award-winning PRS Journal Club Podcast, 2025 Resident Ambassadors to the PRS Editorial Board – Christopher Kalmar, Ilana Margulies, and Amanda Sergesketter- and special guest, Jesse Selber, MD, discuss the following articles from the September 2025 issue: “Nipple-Sparing Mastectomy with Immediate Breast Reconstruction: The Laterothoracic Approach without Robotic Assistance” by Pozzo, Lhuaire, Mernier, et al. Read the article for FREE: https://bit.ly/NSM_IBR Special guest, Jesse Selber, MD, was most recently the Acting Chair, the Director of Clinical Research and Professor in the Department of Plastic Surgery at the University of Texas MD Anderson Cancer Center. Currently, he is a Physician Executive and the Surgery Service Line Chief of Beaumont, where he also serves as Professor of Plastic Surgery. In this role, Dr. Selber is responsible for all surgical activities within the Beaumont System, including 8 hospitals overseeing 2000 surgeons. Dr. Selber completed surgery residency at the University of Pennsylvania and fellowship in Microvascular Reconstructive Surgery at MD Anderson Cancer Center. Dr. Selber's clinical practice is exclusively complex cancer reconstruction. He is a surgical innovator, developing numerous techniques, and author of the only robotic plastic surgery textbook.  READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCSept25Collection The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

In this episode of the Award-winning PRS Journal Club Podcast, 2025 Resident Ambassadors to the PRS Editorial Board – Christopher Kalmar, Ilana Margulies, and Amanda Sergesketter- and special guest, Jesse Selber, MD, discuss the following articles from the September 2025 issue: “Robotic Nipple-Sparing Mastectomy and Breast Reconstruction with Profunda Artery Perforator Flaps” by Haddock, Teotia, and Farr. Read the article for FREE: https://bit.ly/SPrNSM_PAPflaps Special guest, Jesse Selber, MD, was most recently the Acting Chair, the Director of Clinical Research and Professor in the Department of Plastic Surgery at the University of Texas MD Anderson Cancer Center. Currently, he is a Physician Executive and the Surgery Service Line Chief of Beaumont, where he also serves as Professor of Plastic Surgery. In this role, Dr. Selber is responsible for all surgical activities within the Beaumont System, including 8 hospitals overseeing 2000 surgeons. Dr. Selber completed surgery residency at the University of Pennsylvania and fellowship in Microvascular Reconstructive Surgery at MD Anderson Cancer Center. Dr. Selber's clinical practice is exclusively complex cancer reconstruction. He is a surgical innovator, developing numerous techniques, and author of the only robotic plastic surgery textbook.  READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCSept25Collection The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Dr. Linda Chu speaks with Dr. Andrew Trout, Professor of Radiology and Director of Clinical Research at Cincinnati Children's, and Dr. Erin Angel, Vice President of Research and Scientific Affairs at GE HealthCare. They discuss the unique challenges of pediatric imaging and how collaboration and technology are advancing care for young patients while improving imaging for all. Sponsored by GE HealthCare.

doTERRA's On Guard Essential Oil Blend is one of the most loved blends and for good reason. But what makes it special, and how can you actually use it?   In this episode, Dr. Nicole Stevens, VP of Clinical Research at doTERRA, explains the story behind On Guard, from the powerful essential oils it contains like clove, cinnamon, wild orange, eucalyptus, and rosemary to the science and testing that ensure its purity. You'll also discover simple ways to use On Guard daily, whether it's through diffusing, topical use, or DIY projects.   In this episode, you'll learn:   What makes doTERRA On Guard different from other blends How the oils in On Guard work together in a purposeful way How doTERRA sources and tests every batch for CPTG® quality Easy, everyday uses for On Guard like diffuser blends, surface sprays, and seasonal routines  

Why do so many women struggle with sleep in midlife—and what does body temperature have to do with it? In this eye-opening conversation, we're joined by Nicole Moyen, Director of Clinical Research at Eight Sleep, to explore the science of thermoregulation and sleep optimization. Nicole shows us the data on temperature and its powerful impact on sleep quality—especially for women navigating perimenopause, menopause, and beyond. Nicole breaks down the fascinating relationship between core body temperature and sleep cycles, explains why traditional sleep solutions often fail midlife women, and introduces Eight Sleep's newest game-changing feature: the Hot Flash mode—a smart, dynamic temperature response system designed specifically to help women stay cool, comfortable, and asleep. Topics We Cover: What is thermoregulation and why does it matter so much for sleep? How hormonal fluctuations affect sleep temperature needs Why women tend to “run hotter” at night in midlife The science behind Eight Sleep's Pod system and thermal technology The revolutionary Hot Flash feature: how it works and who it's for Real-world results and what's next in sleep innovation Whether you're struggling with night sweats, tossing and turning, or just looking to optimize your rest, this episode offers cutting-edge insights from the frontlines of sleep science. Better sleep starts with better data—and the right temperature. For more information go to Eight Sleep For more information on the Hot Flash Feature For more information about the Pod and Menopause Click Here Follow Eight Sleep on Instagram @eightsleep Follow Eight Sleep on X @eightsleep Be a part of the every.body.talks. community and join our wellness group: every.body.talks. wellness group Follow us on Instagram: @every.body.talks @jenngiamo @schully Subscribe to our YouTube channel! Don't forget to subscribe to the podcast for free wherever you're listening. Apple Podcasts Spotify Be sure to leave a 5 star rating! It really helps grow the show. If you like the show, telling a friend about it would be amazing!