Podcasts about keck school

Guest: Jorge Nieva, MD As cancer treatment continues to evolve, at-home subcutaneous immunotherapy is at the forefront of decentralized care and research. Here to share his insights on how this delivery model could impact clinical trials and cancer care is Dr. Jorge Nieva, Associate Professor of Clinical Medicine at the University of Southern California's Keck School of Medicine.

Guest: Jorge Nieva, MD Despite the promising benefits for cancer patients, the at-home administration of subcutaneous immunotherapy poses complex operational and logistical challenges, like cost, payer preferences, and patient safety. Tune in to hear Dr. Jorge Nieva discuss these key factors and considerations impacting the implementation of at-home subcutaneous cancer immunotherapy delivery. Dr. Nieva is an Associate Professor of Clinical Medicine at the University of Southern California's Keck School of Medicine.

Guest: Jorge Nieva, MD As immunotherapy becomes a cornerstone for treating a growing number of solid tumors, reducing the logistical burden of in-office care is essential. Fortunately, the at-home administration of subcutaneous formulations of immunotherapy agents like atezolizumab could help transform the way we care for patients with cancer. Learn more with Dr. Jorge Nieva, Associate Professor of Clinical Medicine at the University of Southern California's Keck School of Medicine.

Guest: Jorge Nieva, MD Can the immune checkpoint inhibitor atezolizumab be safely administered subcutaneously at home for patients with non-small cell lung cancer (NSCLC)? That's the exact question an ongoing study is seeking to answer, and here to discuss the study's objective, design, and potential implications for home-based subcutaneous cancer therapies is Dr. Jorge Nivea. He's an Associate Professor of Clinical Medicine at the University of Southern California's Keck School of Medicine.

In this insightful episode of Parallax, Dr Ankur Kalra is joined by Dr Leslie Saxon, a professor of medicine at Keck School of Medicine USC and executive director for the USC Center for Body Computing. Together, they explore the potential network data have in transforming healthcare delivery and patient survival. Beginning with the origin and aim of the USC Center for Body Computing, the episode dives into the benefits of a network of connected implantable devices to engage patients in their own care. Dr Saxon also shares her vision of overseeing "life care” as well as "sick care" by collecting data on the mind and body, providing insights into her work with professional athletes and the military to understand how the body functions as a system. The discussion later turns to the evolution of computing devices and how we are moving past the concept of "wearables" with AI-centric devices designed specifically for continuous health monitoring.

Dean's Chat hosts, Drs. Jeffrey Jensen and Johanna Richey welcome Dr. David Armstrong to the podcast.  This discussion wasn't about the "Diabetic Foot" as much as it was getting to know what makes the world leader in "Diabetic Foot" click.  His background and fascination with technology, intro to podiatry (he considered law) to transforming clinical opportunities at Kern Hospital and UT- San Antonio.   Dr. Armstrong is Distinguished Professor of Surgery and Neurological Surgery with Tenure at the University of Southern California. Dr. Armstrong holds a Master of Science in Tissue Repair and Wound Healing from the University of Wales College of Medicine and a PhD from the University of Manchester College of Medicine, where he was appointed Visiting Professor of Medicine. He is founder and co-Director of the Southwestern Academic Limb Salvage Alliance (SALSA).  Dr. Armstrong has produced more than 720 peer-reviewed research papers in dozens of scholarly medical journals as well as over 120 books or book chapters. He is founding co- Editor of the American Diabetes Association's (ADA) Clinical Care of the Diabetic Foot, now in its fourth edition.  Armstrong is Director of USC's National Science Foundation (NSF) funded Center to Stream Healthcare in Place (C2SHiP) which places him at the nexus of the merger of consumer electronics, wearables, and medical devices in an effort to maximize hospital-free and activity-rich days. Dr. Armstrong was selected as one of the first six International Wound Care Ambassadors and is the recipient of numerous awards and degrees by universities and international medical organizations including the inaugural Georgetown Distinguished Award for Diabetic Limb Salvage. In 2008, he was the 25th and youngest-ever member elected to the Podiatric Medicine Hall of Fame. He was the first surgeon to be appointed University Distinguished Outreach Professor at the University of Arizona. He was also the first podiatric surgeon to be selected as President of Faculty at Keck School of Medicine of USC. Furthermore, he was the first podiatric surgeon to become a member of the Society of Vascular Surgery, and the first US podiatric surgeon named fellow of the Royal College of Surgeons, Glasgow. He is the 2010 and youngest ever recipient of both the ADA's Roger Pecoraro Award and 2023 recipient of the ISDF's Karel Bakker Award, the highest awards given in the field. Dr. Armstrong is past Chair of Scientific Sessions for the ADA's Foot Care Council, and a past member of the National Board of Directors of the American Diabetes Association. He sits on the Infectious Disease Society of America's (IDSA) Diabetic Foot Infection Advisory Committee and is the US appointed delegate to the International Working Group on the Diabetic Foot (IWGDF). Dr. Armstrong is the founder and co-chair of the International Diabetic Foot Conference (DF-Con), the largest annual international symposium on the diabetic foot in the world. He is also the Founding President of the American Limb Preservation Society (ALPS), a medical and surgical society dedicated to building interdisciplinary teams to eliminate preventable amputation in the USA and worldwide. https://limbpreservationsociety.org/ https://bakodx.com/ https://bmef.org/ www.explorepodmed.org https://podiatrist2be.com/  

In 2016, a woman overdosed on meth in a Pasadena hotel room. The man who provided the drugs: Dr. Carmen Puliafito, the dean of USC's Keck School of Medicine. As one reporter at the Los Angeles Times fought to expose the truth, he encountered a power structure that made publishing the story all but impossible.Read Paul's book about this story: https://us.macmillan.com/books/9781250824103/badcity/ For a transcript of this episode: https://bit.ly/campusfiles-transcripts To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Episode OverviewIn this episode of Spiral Deeper, our host, Gaby Azorsky, speaks with Keely Semler. Together, they dive into her origin story and path to working in the interdisciplinary field of women's reproductive health, judgement in birth, safety, discernment, being a mentor and teacher, her educational course and podcast - Motherlands, and more. Thank you for joining us on this journey of self-discovery and growth! Here is a little more about Keely: Keely's career began with a deep commitment to service, working with a nonprofit that provided medical devices to vulnerable populations in war-torn regions. In her early twenties, Keely traveled to remote parts of Africa and Asia, where she discovered her true calling: to serve and uplift women in their most transformative moments. Driven by this mission, Keely pursued a Master's in Maternal and Child Health from the Keck School of Medicine at the University of Southern California. Upon graduation, she joined a Hospitalist Medical Group, but it was clear her heart lay in direct patient care, where she could make a more personal impact. With this newfound clarity, Keely transitioned to offering her expertise as a Doula and Health Educator, initially providing pro bono support to underserved communities in Los Angeles. Over the years, Keely has supported hundreds of families in both hospital and home settings, always with a focus on holistic, compassionate care. During the pandemic, Keely expanded her knowledge by studying Midwifery Care, which further deepened her understanding of family-centered care. As a student midwife, she reimagined the possibilities of women's health and became devoted to educating and empowering women to honor their bodies, autonomy, and unique paths. Keely's teaching philosophy draws from her background in Public Health, Medical Anthropology, and holistic wellness. This integrated approach allows her to support healthy, informed individuals while also tending to the emotional and energetic dimensions of care. She moves beyond clinical frameworks to explore the deeper ceremony of caregiving and how we show up for one another as a personal, collective, and ecological practice. As her work evolved, Keely offers advance training and mentorship, helping to cultivate the next generation of empowered health educators and professionals.Special OfferCODE - SPIRALOFFLOWERS for 20% off your first month in The Flower Portal!EVENTS - 4/19 Tarot at Noto in Los Angeles, 4/23 Flower Portal Cacao Workshop, 5/30-5/31 The Sacred Pause Retreat in Ojai CaliforniaConnect and Work with GabyInspiring the connection between Heaven and Earth through Reiki, Tarot, Folk herbalism, Clairvoyance, and Meditation. Together, we co-create harmony, clarity, and alignment with your True Essence. I'd love to support you!Visit my website to learn more: gabyazorsky.comFollow me on Instagram: @gaby.azorskyNewsletter: Sign Up HereBook a 1:1 Session: Book HereJoin My Membership, The Flower Portal: Learn MoreWith Spiral DeeperWebsite - Spiral Deeper PodcastInstagram - @spiral.deeperWith Our Guest, Keely SemlerWebsite - https://www.wearemotherlands.com and https://www.keelysemler.comInstagram - @we.are.motherlandsCreditsSpecial thanks to…Music - Connor HayesSpiral Deeper Icon - Kami MarchandCollaborate with UsInterested in advertising or collaborating with Spiral Deeper? Email gabyazorsky@gmail.com for packages and details.Support the ShowPlease rate, review, and subscribe wherever you listen - it means so much. Be sure to tag @spiral.deeper if you share; thank you for your support!

In this episode, we delve into the often-overlooked value of caregiving in a society obsessed with speed and material success. Our guest, Keely Semler, a doula and health educator with a master's in maternal and child health, shares her journey from the nonprofit world to becoming a doula. We discuss the misconceptions about birth, the transformation women experience during pregnancy, and the societal shift away from family values and caregiving. Keely emphasizes the importance of both external resources and internal intuition in navigating the complexities of birth and fertility. Tune in for a profound conversation about the trade-offs women face in modern society and the importance of embracing our innate wisdom.About Keely:Keely's career began with a deep commitment to service, working with a nonprofit that provided medical devices to vulnerable populations in war-torn regions.Driven by this mission, Keely pursued a Master's in Maternal and Child Health from the Keck School of Medicine at the University of Southern California. With this newfound clarity, Keely transitioned to offering her expertise as a Doula and Health Educator, initially providing pro bono support to underserved communities in Los Angeles. Over the years, Keely has supported hundreds of families in both hospital and home settings, always with a focus on holistic, compassionate care. Keely's teaching philosophy draws on her diverse training, including Public Health, Medical Anthropology, and holistic wellness. With this well-rounded approach, she works to foster healthy, informed communities where women are at the center of their care.To connect with Keely:IG: we.are.motherlandsWww.keelysemler.comWww.wearemotherlands.comThe motherlands podcast on Spotify, Apple and Substack.

Geoengineering experiments face an uphill battle, and a way to combat the pregnancy complication hyperemesis gravidarum First up on the podcast, climate engineers face tough conversations with the public when proposing plans to test new technologies. Freelance science journalist Rebekah White joins host Sarah Crespi to discuss the questions people have about these experiments and how researchers can get collaboration and buy-in for testing ideas such as changing the atmosphere to reflect more sunlight or altering the ocean to suck up more carbon dioxide.   Next on the show, hyperemesis gravidarum—severe nausea and vomiting during pregnancy—is common in many pregnant people and can have lasting maternal and infant health effects. This week, Marlena Fejzo wrote about her path from suffering hyperemesis gravidarum to finding linked genes and treatments for this debilitating complication. For her essay, Fejzo was named the first winner of the BioInnovation Institute & Science Translational Medicine Prize for Innovations in Women's Health. Fejzo is a scientist at the Center for Genetic Epidemiology in the department of population and public health sciences at the University of Southern California's Keck School of Medicine.   This week's episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Rebekah White Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Brain & Life Podcast, host Dr. Daniel Correa is joined by comedian and actress Kellye Howard, who shares about her Multiple Sclerosis (MS) diagnosis process and how she manages symptoms in her daily routine. Dr. Correa is then once again joined by Dr. Lilyana Amezcua, a neurologist and MS specialist based out of Los Angeles at USC and the Keck School of Medicine. Dr. Amezcua explains MS and discusses some of the disparities in care amongst different communities.   Additional Resources Expert Insights and Practical Tips for Managing Multiple Sclerosis MS-ing Around with Kellye Howard How Multiple Sclerosis Affects Black People How Exercise Helps Those with Multiple Sclerosis   Other Brain & Life Podcast Episodes Voices from the Multiple Sclerosis Community   We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? ·       Record a voicemail at 612-928-6206 ·       Email us at BLpodcast@brainandlife.org   Social Media: Kellye Howard @kellyehoward; Dr. Lilyana Amezcua @keckschoolusc Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD

Geoengineering experiments face an uphill battle, and a way to combat the pregnancy complication hyperemesis gravidarum First up on the podcast, climate engineers face tough conversations with the public when proposing plans to test new technologies. Freelance science journalist Rebekah White joins host Sarah Crespi to discuss the questions people have about these experiments and how researchers can get collaboration and buy-in for testing ideas such as changing the atmosphere to reflect more sunlight or altering the ocean to suck up more carbon dioxide.   Next on the show, hyperemesis gravidarum—severe nausea and vomiting during pregnancy—is common in many pregnant people and can have lasting maternal and infant health effects. This week, Marlena Fejzo wrote about her path from suffering hyperemesis gravidarum to finding linked genes and treatments for this debilitating complication. For her essay, Fejzo was named the first winner of the BioInnovation Institute & Science Translational Medicine Prize for Innovations in Women's Health. Fejzo is a scientist at the Center for Genetic Epidemiology in the department of population and public health sciences at the University of Southern California's Keck School of Medicine.   This week's episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Rebekah White Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the St Emlyn's podcast, hosts Iain Beardsell and Liz Crowe welcome Dan Dworkis, an ER doctor from Los Angeles and host of the Emergency Mind podcast. Dan shares his expertise on optimizing team and individual performance in high-stress medical environments. The discussion delves into the concept of excellence beyond merely avoiding negative outcomes, using a rosebush metaphor to illustrate the need for proactive growth. They explore how teams can benchmark and improve performance, the importance of creating a culture of continuous improvement, and strategies to maintain positivity and energy even in challenging conditions. Dan also highlights the Mission Critical Team Institute and its role in supporting teams in life-or-death situations. This episode is essential listening for medical professionals committed to pushing the boundaries of excellence in their practice.   00:00 Introduction and Guest Welcome 01:06 Defining Excellence in Medicine 02:29 Measuring and Achieving Team Performance 06:13 Small Changes for Big Impact 10:03 Maintaining Positivity and Energy 15:30 Mission Critical Team Institute 16:33 Conclusion and Farewell   The Guest - Dan Dworkis Dan Dworkis, MD, PhD, FACEP is the Chief Medical Officer at the Mission Critical Team Institute, the founder of The Emergency Mind Project, a board-certified emergency medicine physician, and an assistant professor at the Keck School of Medicine at USC. His work focuses on the optimal development of mission critical teams in and out of emergency departments. He completed the Harvard Affiliated Emergency Medicine Residency at Massachusetts General Hospital / Brigham Health, and also earned an MD and PhD in molecular medicine from Boston University School of Medicine. Dr. Dworkis is the author of The Emergency Mind:  Wiring Your Brain for Performance Under Pressure.      

In today's episode, supported by Revolution Medicines, we had the pleasure of speaking with Heinz-Josef Lenz, MD, about RAS mutations in pancreatic ductal adenocarcinoma (PDAC). Dr Lenz is a professor of medicine at the Keck School of Medicine of the University of Southern California (USC), as well as the J. Terrence Lanni Chair in Gastrointestinal Cancer Research, co-director of the USC Center for Molecular Pathway and Drug Discovery, and co-director of the USC Norris Center for Cancer Drug Development in Los Angeles. In our exclusive interview, Dr Lenz discussed the prevalence of RAS mutations in PDAC, the importance of biomarker testing, current treatment strategies for patients with RAS-mutant PDAC, and potential future treatment advances for patients with this disease.

Dr. Guy Young, Director of the Hemostasis and Thrombosis Program, Attending Physician in Hematology-Oncology, and Professor of Pediatrics at Keck School of Medicine at the University of Southern California (USC), is currently serving as co-chair of i3 Health's CME/NCPD activity, Practice-Changing Advances in the Management of Hemophilia. With new developments in the field occurring over recent months, Dr. Young sat down with us to share recent updates in the hemophilia treatment and management. Click the links below for the full activity! Online accredited CME/NCPD activity: https://i3health.com/course-information/practice-changing-advances-in-the-management-of-hemophilia Accredited CME/NCPD podcast: https://i3health.com/course-information/practice-changing-advances-in-the-management-of-hemophilia-podcast

Send us a text In this episode of Causes or Cures, Dr. Eeks sits down with Dr. Sherlock Li to explore his recent research on the impact of forever chemicals (PFAS) on sleep, a pressing public health concern given the strong links between poor sleep and a range of health issues. Dr. Li begins by providing an overview of what forever chemicals are and how they persist in the environment and human body. He then delves into the methodology of his latest study, detailing the observed effects of PFAS on sleep patterns and the emerging theories behind these disruptions. The conversation also touches on the broader public health implications of PFAS exposure and Dr. Li's cautionary note that the replacement chemicals being introduced may not offer any improvements for our well-being. Dr. Sherlock Li, PhD, is a postdoctoral researcher in the Department of Population and Public Health Sciences at the Keck School of Medicine. You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the show

Dr. John Martin is a virologist and medical researcher who has greatly contributed to the study of viral infections and their role in chronic diseases. He is the medical director of the Institute for Progressive Medicine at the non-profit charity MI Hope that supports those with mental illness. During his tenure at the National Institute of Allergy and Infectious Diseases (NIAID) Dr. Martin significantly increased our understanding of viruses such as HIV, hepatitis, and herpesviruses. He later worked as Chief of the FDA's Virus Oncology Laboratory evaluating vaccine safety, especially vaccine contamination with adventitious agents, which led to his interest in stealth-adapted viruses -- viruses that are not recognized by our immune system. This research led to his theory that such stealth pathogens, such as simian cytomegalovirus contamination in the polio vaccines, could contribute to a wide range of chronic illnesses including neuropsychiatric disorders such as autism and chronic fatigue. Following his work in government health agencies, John was a professor of pathology at the Keck School of Medicine at the University of Southern California. His current research is focused on Kinetic Energy Limiting Electrostatic Attraction or KELEA, which can aid immune function, suppress stealth viruses, enhance water for crops and for purifying ecological environments. He holds an MD and a separate PhD from the University of Sydney and University of Melbourne respectively.   

Host Dr. Davide Soldato and his guests Dr. Ann Wu and Dr. Alexa White discuss the article "Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study" and the editorial "Growing Evidence for the Role of Air Pollution in Breast Cancer Development"  TRANSCRIPT The guests on this podcast episode have no disclosures to declare.  Dr. Davide Soldato: Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, Medical Oncologist at Ospedale San Martino in Genoa, Italy.  Today, we are joined by JCO authors Dr. Anna Wu and Dr. Alexander White. Dr. Wu is a professor of Population and Public Health Sciences at the Keck School of Medicine of UCS, while Dr. White is an investigator in the Epidemiology branch of the Environment and Cancer Epidemiology Group at the National Institute of Health.  Today, we will be discussing the article titled, “Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study,” and the accompanying editorial.  So, thank you for speaking with us, Dr. Wu, Dr. White. Dr. Anna Wu: Thank you for having us. Dr. Alexandra White: Yes, thank you so much for the invitation to be here. Dr. Davide Soldato: So before going in depth about the results of the study that was published in the JCO, I was wondering if you could give us like a brief introduction and a little bit of background about what was known about air pollution as a risk factor for breast cancer and what was the evidence before this study was conducted. Dr. Alexandra White: Okay. I can start with that question. So, there's been research for decades looking at the relationship between air pollution and breast cancer. And it's been a really challenging question to address for a number of reasons. One being that it can be really difficult to assess exposure to air pollution and many previous studies have had really limited information on people's residences over time. But in general, what we thought leading up to this study was that evidence was most consistent that exposure to traffic related pollutants such as nitrogen dioxide was more consistently related to a higher risk of breast cancer. The evidence for fine particulate matter or PM2.5 was less consistent. More recently, there have been a few large, well conducted studies that have supported a positive association. This new study in the multiethnic cohort led by Dr. Wu is really important because it really demonstrated that, in this large study of over 50,000 women in California, that they also do see an association with PM2.5.  Dr. Davide Soldato: Thank you very much for the introduction. So, Dr. Wu, we just want to hear a little bit more about the results. So, what was the association that was observed for PM2.5? And specifically, the study that you ran was focused on a very diverse population, a multiethnic cohort, and so I was wondering if you observed any type of differences when you consider the different populations that were included in your study. And if you could also give us a little bit of what was the composition of the women that were enrolled in this cohort. Dr. Anna Wu: Thank you for the question. So, the multiethnic cohort study is a cohort of over 200,000 individuals who were enrolled when they lived in Hawaii or California. For the air pollution studies that we've been conducting, we have focused on primarily the California participants. And in this instance for the breast cancer study, it was based on roughly 56,000 individuals out of- there were about 100,000 because half of them were men and they were not included. Of the California participants, 75% of them were African Americans or Latinos and they were self-identified as these racial ethnic groups when they enrolled in the study. And this was a particularly important consideration for us because in most of the studies that have been published so far on-air pollution and breast cancer, as well as other cancer sites, most of those studies were conducted among whites in the US or whites in Europe. And even if they included non-white populations, the numbers tend to be small so that they were not able to conduct racial ethnic specific analysis. So, we were particularly interested in examining these other racial ethnic groups because we know from other studies that racial ethnic minority groups tend to live in communities of low socioeconomic status and those communities also tend to have higher levels of various types of environmental pollutants. And so, it was important for us to actually try to tease apart these various interrelated factors.  So, what we found was that per 10 micrograms per cubic meter, we had a 28% increased risk overall in all participants combined that meet across the racial ethnic groups. We actually did not see any differences or significant differences in the hazard ratios by race ethnicity and they were in general quite compatible with each other. But we did see a stronger finding among the white participants in our study. Dr. Davide Soldato: Thank you, a lot, Dr. Wu. So, I think it's very interesting the fact that in the end you observed that air pollution is a significant risk factor across all the ethnicities that were included in the study. But I think that one very strong point of the manuscript and one very strong point of the analysis was that in the end you also corrected for a series of different factors because we know that the incidence of breast cancer can be modified, for example, by familial history or BMI or smoking habits or also alcohol consumption. And a lot of these risk factors were included in your analysis. And so, I was wondering if you could tell us a little bit whether you observed any significant differences when you observed or included also these risk factors in your analysis, or whether the association for air pollution as a risk factor stands even when we consider all of these other elements. Dr. Anna Wu: Yes. So, we considered all the well-established breast cancer risk factors. And in this situation, we were particularly interested in considering smoking, alcohol intake, use of menopausal hormones, history of diabetes, body mass index, family history, as well as physical activity, because many of these risk factors, such as, for example, diabetes and body mass index, they are risk factors for breast cancer, and air pollution, have also been found to increase risk of these factors.  So, in our analysis, we first adjusted for all of these potential confounders in a mutually adjusted manner, so all of them were considered. In addition, we also conducted stratify analysis. So as an example, we stratified the analysis to examine whether the hazard ratio associated with PM2.5 provided comparable risk estimate or hazard ratio estimates for never smokers, former smokers, and current smokers. Although we did not see significant heterogeneity by these various subgroups, we did see a significantly stronger effect of PM2.5 among individuals who did not have a family history of breast cancer.  Interestingly, our finding was also stronger among individuals who were never smokers and light alcohol drinkers, even though the results were not significantly different. So, we surmised that maybe individuals who already had a high risk because of other established risk factors for breast cancer, we were less likely to be able to observe the effect of air pollution. But it's important to note that other studies, such as the ones that Dr. White has conducted, have also looked at various subgroups, and I think part of the limitation that all of us have is that once you subdivide the study population, even if you start out with a large sample size, often the sample size gets cut in half or a third. And so, we still lack the statistical power to be able to observe significant differences. But I think it is important to note that, in fact, the hazard ratio estimates are actually quite comparable, but we did see a hint of stronger effects among never smokers, and people who were light alcohol drinkers. So, I think this is an area that we certainly need to continue to investigate since there are other subgroups, such as menopausal status, such as hormone receptor status of breast cancer, that we need to consider in future studies. There's still a lot of work we need to do to sort this out, to actually figure out who are the women who are the most susceptible to the exposures. Dr. Davide Soldato: Dr. White, I would really love a comment from you on this specific area and specifically on what still needs to be done. And related to this, a question actually, for both of you, because I think that from a methodological point of view, there is a lot of work that goes into deciding how we are going to assess the exposure to air pollution. So which type of data are we going to use? Which type of data are we currently using in the epidemiological studies that have been conducted and in the one that we are discussing right now in JCO? And what are the caveats for this data that we are using? Meaning, I think that we use mostly residential addresses, which means that we are looking at the exposure where people actually live, which might not be the place where they spend most of their time. For example, if someone is working, maybe they could be more exposed and have higher exposure when they are at work compared to when they are at home. So, I was wondering if you could give us a little bit of an overview as to what is the methodological standard of care right now in terms of this analysis and what can we do better to refine and understand this specific factor as Dr. Wu was mentioning? Dr. Alexandra White: Yeah, so I'm happy to take a first stab at that question. So, I think it's important to note just how far we've come. I think even a few years ago, air pollution was really not considered a risk factor for breast cancer. And a lot of the work that we've been doing and others have really moved this forward in terms of understanding this as a risk factor. And as I mentioned earlier, there have been a lot of challenges in exposure assessment. And to get to your question, I think that our studies in general are doing better at looking at exposure over more years, residences, more time. We know that cancer takes time to develop, and we can't rely on just a single snapshot of exposure. But as you mentioned, almost all of the studies published have really exclusively focused on residential estimates of exposure. And so, there's a real need to understand the exposures that people are experiencing in other aspects of their life, from their commute to their jobs, to really capture that totality of exposure.  And then I think one of the points that Dr. Wu was alluding to as well as we know that breast cancer is a very heterogeneous disease, so risk factors for breast cancer vary by tumor subtypes, by menopausal status at diagnosis. And a lot of studies have really focused on considering breast cancer as a combined outcome, and that might be missing some really important signals where we might have a stronger effect for certain subtypes due to the fact that there's different biologic pathways that are underlying these subtypes or by menopausal status. And so having large study populations where, as we discussed earlier, would really give us the power to look among these smaller groups of women who might be more susceptible and those with younger women, we know that incidence of cancer is rising in young people, and we need to understand the risk factors for that. And most of our studies are really focused on older individuals, so I think that's one important gap, as well as having the power to really look at different differences by tumor subtypes. Dr. Davide Soldato: I think it's very interesting, and I think one point both of you made in the original article and in the accompanying editorial is also the fact that we tend to look at these risk factors in people who are actually aged, while we maybe should be looking at this in an earlier phase of development and potentially during puberty. Do you think that we should design studies that are more focused on this population even though I think that they will take a lot of time to produce significant results?  Dr. Alexandra White: Yeah. I think that it is really important to consider how exposure during early life is related to breast cancer risk. We know that exposures during pregnancy or even as early as during puberty might be particularly relevant for breast cancer. And I think a lot of our studies have really been up against the challenge of the fact that exposure monitoring for air pollution really didn't start until the 1990s. And so, it's challenging, especially for these older cohorts, to get back at that time period that might be relevant. But I think that's something that definitely newer cohorts are going to be able to address, and I think it's going to be really important, and also will give us some clues to better understand the important windows of exposure, but also that might provide clues for the biologic pathways as well that are relevant. Dr. Davide Soldato: And just a related question, because I'm not aware of this, but are there right now cohorts that are specifically looking at this in the US or in other parts of the world? If you are aware of that, of course.  Dr. Alexandra White: There have been some cohorts that have focused on exposure during these hypothesized windows of susceptibility, but I don't think they've been able to follow those women long enough to develop breast cancer. One of the things that we're working on in the sister study is trying to expand our assessment of air pollution exposure back in time to try to get at these earlier windows of exposure. So, I'm hoping that it's something we'll be able to comment on and at least for some of the women in our cohort who are younger. But I don't know, Dr. Wu, if you're familiar with any other populations that are doing this now?  Dr. Anna Wu: Well, NCI funded several new cohorts in the last couple years that are really focused on trying to get a much more refined exposure assessment. So, I know colleagues at University of Michigan that are peers and also Dr. Wei Zheng at Vanderbilt, they are putting together newer cohorts that are younger and also trying to include a range of exposure, not just air pollution, but really environmental exposures. Those cohorts I think have the potential in the future to try to address some of these questions, but again, it will take at least another number of years before there are a sufficient number of endpoints so that they can actually do these types of studies.  Another possibility is that there are a number of big cohort studies in Asia. The age of diagnosis tends to be earlier in Asia. I know that investigators in China are very interested and concerned with the air pollution effects in China. I think there are potentials that in other countries where the age of breast cancer diagnosis is actually younger than in the US and if they establish in a manner that allows them to assess air pollution that they may have opportunities.  And I think the other way to try to address this question, whether there are studies where you can actually tap into either biomarkers or pathology samples so you won't be actually studying air pollution in a large population, but you're actually narrowing it down to try to see if you see any signals in a way that would give you some additional clues and insights as to the mechanism. So I think we're going to have to piece together various types of study to try to answer the questions because one type of study like these observational air pollution studies, will allow us to address one slice of the questions that we have and then we need to put together other studies so that we can address other aspects that we're interested in to put it together. Dr. Davide Soldato: Thank you very much both of you. That was very interesting.  Coming back to the results of the manuscript, we really focused up until now on PM2.5. But it's true that inside of the study you evaluated different pollutants. So, I was wondering whether you saw a similar association for other pollutants that were included in the study or whether the association for higher risk was observed only for PM2.5. Dr. Anna Wu: The results for NO2, NOx, PM10, and carbon monoxide were actually very compatible with the risk estimates that other studies have published as well as from the meta-analysis. So, I would say that our results from the other pollutants are actually very consistent with other results. I think one difference is that our PM2.5 estimates were based on the satellite-based PM2.5 estimates, whereas all the other pollutants were based on monitoring station estimates from EPA sponsored air monitoring stations. So, they are not measured in the same way. And I think different studies over time have used either monitoring station type measures for other pollutants. And I think we were particularly interested in PM2.5 because the measurement of PM2.5 in the monitoring world didn't start until around 2000. So, studies up until that time were less able to actually provide the assessment of PM2.5 as good as we can for air pollution. There's always misclassification. So, I think it's a matter of how much misclassification in the assessment. But, again, we are really limited in really just having exposure over one part of adult life.  Dr. Davide Soldato: Thank you very much. And one potentially related question. We are speaking in general about air pollution, but I think that since we are considering residential addresses, probably we are capturing more either traffic pollution or pollution that comes from probably industries or stuff like that, which is mostly related to residential areas or the place where people live. But I think that in the end we also think about air pollution as something that can come from different forms. And one very interesting point, Dr. White, that you made in your editorial is also that there is a global change also in the way we are faced with air pollution. For example, you made the example of wildfires in your editorial and how this might potentially change exposure to air pollution, maybe for limited times, but with concentrations that are fairly higher compared to what we generally observed. So, I was wondering if you could comment a little bit on that and also, if there is potentially a way to also consider this in future epidemiological studies. Dr. Alexandra White: Yeah, so when we talk about exposure to fine particulate matter, PM2.5, we're assessing exposure to particles that are based on the size of the particle, and we're really not evaluating the types of particles that people are experiencing exposure to. And we know that, in general, that PM2.5 composition really varies geographically due to differing sources of exposure. So, like you were saying, there might be a stronger contribution to industry or from agriculture or from traffic. And so that could really change the PM2.5 exposure profile that individuals experience. And so it could be that this is another really important area that this research needs to consider, which could really help us identify what sources of exposure are most relevant.   Wildfires are a really important growing concern. We know that wildfires are increasing in both intensity and duration and frequency, and we really don't understand the long-term health impacts of wildfires. But we know that wildfire associated PM2.5 might be one of the most dominant contributors to PM2.5 moving forward. And although we've seen historic declines in PM2.5 in the US after the Clean Air Act, those declines have really stalled. PM2.5 itself is projected to increase over the next few decades, so understanding different PM2.5 composition profiles and the sources that drive them can really help us identify the most important targets for any potential interventions. And wildfire PM2.5 in particular may be of concern because it's a combustion byproduct, and so it's thought to have more of the components that might, we hypothesize, are most relevant for breast cancer, such as PAHs or polycyclic aromatic hydrocarbons or metals. And so, these components are thought to act as endocrine disruptors, which may be particularly relevant for breast cancer. So, I think understanding this changing landscape of PM2.5 moving forward is going to be really important in understanding how PM2.5 contributes to cancers beyond just breast, but as well as other female hormone driven cancers and all of the cancers really.  Dr. Davide Soldato: Thank you very much. So, one closing remark, because I think that in general, we have been really in a field of primary prevention for breast cancer where we were focusing on individual behaviors, for example, smoking cessation, reduction in alcohol intake, reduction of BMI, increase of physical activity. But I think that the evidence that is accumulating in the last three years or so is telling us more and more that we also need to shift the perspective on prevention going not only on individuals, but also as including environmental risk. So, I was wondering, how can we include this new evidence in the policies that we implement and how policymakers should act on the data that we have available right now? Dr. Anna Wu: I think it's really important that this new information is communicated to all the stakeholders, including our policymakers, so that they are, first of all, really aware that any changes and not actually adhering to current guidelines can have long lasting consequences, deleterious consequences. And I think it's important to also note that over 90% of the world actually live in areas where PM2.5 exceeds the limit. We have observed increases in breast cancer in many middle- and low-income countries, so I think it's particularly important to emphasize that this is really not just a western country issue, it is really a global issue. Dr. Alexandra White: I agree. And I would just add to that that air pollution is not something that an individual can really change on their own. There are things you can do, you can monitor air quality, you can try to live in a home that's far away from traffic. But really these are large scale problems that really require large scale solutions. And we know that policy changes can be effective here and that this is something that, in my opinion, is not something that we leave to the individual to change. This is something that we as a society should encourage change for the health of everyone. Dr. Davide Soldato: So, thank you very much again, Dr. Wu, Dr. White, for joining us today on the podcast. Dr. Anna Wu: Thank you. Dr. Alexandra White: Thank you so much for having us.  Dr. Davide Soldato: So we appreciate you sharing more on your JCO article and accompanying editorial titled, “Air Pollution and Breast Cancer Incidents in the Multiethnic Cohort Study.”  If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.      

Patrick Crispen, Director of Educational Technology at Keck School of Medicine of USC and frequent contributor on The Steve and Johnnie Show, joins Lisa Dent for an update from the ground in Los Angeles. Patrick and his family are among thousands of other residents who have been forced to evacuate their homes as winds reaching […]

Nearly three million people worldwide are living with multiple sclerosis (MS), affecting individuals from diverse geographical, ethnic, racial, and socio-economic backgrounds. This diversity raises important questions about how these factors may influence the experiences and outcomes of those with MS, as well as whether research studies and clinical trials have sufficiently addressed this variability. To answer these questions and more, host Brett Drummond of MSTranslate speaks with two leading researchers in this field: Dr. Léorah Freeman, assistant professor at the Dell Medical School Department of Neurology, The University of Texas at Austin; and Dr. Lilyana Amezcua, Associate Professor of Clinical Neurology at the University of Southern California's Keck School of Medicine.

Today we are bringing you insights from 3 separate interviews with experts about the treatment, management, and burdens of idiopathic pulmonary fibrosis (IPF). In this podcast, you'll hear insight from the following individuals: Toby Maher, MD, PhD, professor of clinical medicine, Keck School of Medicine, USC; Martin Kolb, MD, PhD, professor of medicine, McMaster University; and Steven Nathan, MD, FCCP, medical director of the Advanced Lung Disease Program and Lung Transplant Program, Inova Fairfax Hospital, and professor of medicine, University of Virginia. These experts discuss what IPF is, how it impacts patients' quality of life, barriers to care, and treatments in the pipeline.

As we get closer to 2025, Johnnie Putman and Steve King return with another show to prep you for the holiday! It’s a shorter show, but a great show nonetheless! We catch up with Patrick Crispen, Director of Educational Technology at Keck School of Medicine of USC on the latest tech news and phone problems. […]

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: A push to change the defined stages of T1D, InsuJet is approved in Canada, new study linked T2D and dementia, new drug looked at to prevent hypoglycemia, big honors for a T1D author and more! Our interview with Clare Edge here.  Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom  Edgepark Medical Supplies Check out VIVI Cap to protect your insulin from extreme temperatures Learn more about AG1 from Athletic Greens  Drive research that matters through the T1D Exchange The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links:     Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX   The understanding of type 1 has changed a lot in the last 10-15 years, specifically with the definition of stages of the disease. Now some researchers suggest the current 2015 model is ready for another update. University of Florida Health diabetes researchers and collaborators last week issued a call to action in The Lancet Diabetes & Endocrinology, urging the development of a more precise method of calculating type 1 diabetes risk. Under the current staging system, this is Stage 1 of the disease, when a patient does not yet have elevated blood sugar but has two or more of these autoantibodies in the blood. Stage 2 is diagnosed when blood sugar begins to rise, indicating a dysfunctional pancreas in a patient who does not yet have clinical type 1 diabetes. That comes in Stage 3 with high blood sugar and, eventually, the classic symptoms of the disease, including frequent urination, weight loss and fatigue. Jacobsen, however, said the staging system requires more precision. This is especially important as the current staging model determines if a patient is eligible to receive a drug therapy called teplizumab, the only Food and Drug Administration-approved medication that can delay the onset of type 1 diabetes by an average of two years. The staging system, however, does not include a patient's age and these researchers say additional markers that would be important to consider include a greater array of abnormal metabolic measures beyond blood sugar and the presence of more autoantibodies.   https://www.gainesville.com/story/news/healthcare/2024/12/04/uf-health-scientists-propose-update-to-type-1-diabetes-staging-system/76734459007/ XX A product called InsuJet gets approval in Canada. Made by NuGen Medical Devices, InsuJet™ is a needle-free injection system. It's already approved for sale in 42 countries – not yet the US. Their website says InsuJet's jet-injected fluid penetrates the skin through a small orifice of a special nozzle, creating a thin, high pressure stream. This way, insulin doesn't remain around the place of injection, like it does with a needle. Instead, with InsuJet, the insulin is deposited into the subcutaneous tissue where it's easily absorbed and acts faster– saving you money, time, and discomfort.   https://finance.yahoo.com/news/nugen-announces-canada-wide-launch-221500674.html XX Individuals diagnosed with type 2 diabetes before the age of 50 may be at a higher risk of developing dementia later in life. A study led by researchers at NYU Rory Meyers College of Nursing, says the risk is notably greater among adults with obesity. Type 2 diabetes is a known risk factor for dementia. Although the underlying mechanisms are not fully understood, scientists think that some of the hallmarks of diabetes—such as high blood sugar, insulin resistance, and inflammation—may encourage the development of dementia in the brain.     The researchers note that this greater understanding of the connection between diabetes onset, obesity, and dementia may help inform targeted interventions to prevent dementia. https://scitechdaily.com/diagnosed-young-with-diabetes-your-dementia-risk-may-be-higher/ XX Embecta is out of the insulin patch pump business – just months after getting the ok from the FDA. Embecta received FDA clearance for its insulin patch pump in September. The device is indicated for people with Type 1 or Type 2 diabetes and includes a 300-unit insulin reservoir to support people with higher daily insulin needs. However, the version Embecta received clearance for was an open-loop patch pump, where users manually control insulin delivery, while the firm's goal was to develop a closed-loop version, which automatically delivers insulin when needed. The CEO also expects competition in closed-loop devices for people with Type 2 diabetes to intensify, with Insulet receiving FDA clearance for its Omnipod 5 patch pump for Type 2 diabetes in August. https://www.medtechdive.com/news/embecta-discontinue-patch-pump/734059/ XX Sanofi invests in a company developing a new drug to prevent hypoglycemia. We reported on Zucara Therapeutics back in 2022 and they've been moving ahead with ZT-01. ZT-01 is a medication being developed to help prevent dangerous low blood sugar (hypoglycemia) by fixing how the body normally fights it. In people without diabetes, a hormone called glucagon is released to raise blood sugar when it gets too low. But in people with insulin-dependent diabetes, like type 1 diabetes or some forms of type 2 diabetes, this process doesn't work well because another hormone, somatostatin (SST), blocks glucagon from being released. ZT-01 works by blocking the effects of somatostatin, allowing the body to release more glucagon when it's needed. This could help people with diabetes avoid severe low blood sugar episodes.   https://www.prnewswire.com/news-releases/zucara-therapeutics-announces-strategic-investment-from-sanofi-as-part-of-us20-million-series-b-financing-302301820.html XX Omnipod 5 is now compatible with the FreeStyle Libre 2 plus. The company says the recent development “ makes Omnipod 5 the most connected tubeless AID system in the U.S.” It's already compatible with Dexcom's G6 and G7 CGMs. https://www.businesswire.com/news/home/20241120268759/en/Insulet-Announces-Omnipod%C2%AE-5-System-is-Now-Compatible-with-Abbott%E2%80%99s-FreeStyle-Libre-2-Plus-Sensor-in-the-U.S. XX A new study involving 11 clinical centers across the United States aims to uncover how type 1 diabetes (T1D) impacts brain health and cognitive function in children. Led by the Keck School of Medicine of the University of Southern California, this is a five-year study to explore critical questions about how environmental, lifestyle, social and clinical factors affect brain development during childhood — a period crucial for cognitive growth. https://www.managedhealthcareexecutive.com/view/new-study-to-explore-impact-of-type-1-diabetes-on-children-s-brain-development XX Dexcom looking to partner with smart ring company Oura. Originally launched to track sleep patterns, the latest Oura technology collects more than 20 biometrics ranging from heart rate and activity metrics to sleep and body temperature monitoring. The companies say the new partnership is intended to provide users with seamless integration between the two ecosystems so shared users can track their glucose levels and understand the impact of behaviors and biology on their metabolic health. https://www.forbes.com/sites/saibala/2024/11/29/smart-ring-maker-oura-hits-5-billion-in-valuation--strikes-major-partnership-with-dexcom/ XX   WEDNESDAY, Dec. 4, 2024 (HealthDay News) -- Taking even high doses of supplementary vitamin D won't lower an older person's odds for type 2 diabetes, new research confirms. They published their findings Dec. 2 in the journal Diabetologia. The new research followed on data from other studies that had suggested that people with especially low levels of vitamin D might face a higher risk for diabetes. That was true for people who were already prediabetic, especially. To find out, researchers led by Jirki Vyrtanen, from the University of Eastern Finland, randomly assigned nearly 2,300 people aged 60 or older to receive either placebo pills or 40 or 80 micrograms of vitamin D3 supplements per day, for five years.  At the end of the five years, "105 participants developed type 2 diabetes: 38 in the placebo group, 31 in the group receiving 40 micrograms of vitamin D3 per day, and 36 in the group receiving 80 micrograms of vitamin D3 per day," according to a university news release. In other words, there were no significant differences in the rate at which people developed type 2 diabetes, regardless of how much supplemental vitamin D they took. Vytanen's team also saw no benefit from high-dose supplements on a person's blood sugar or insulin levels, or measures of overweight/obesity. The bottom line, according to the researchers: For any healthy, non-prediabetic person with healthy vitamin D levels, upping intake of the vitamin won't alter your odds for diabetes or its common risk factors. https://www.usnews.com/news/health-news/articles/2024-12-04/high-dose-vitamin-d-supplements-wont-prevent-diabetes-in-healthy-seniors XX Big congrats to author Clare Edge – recent guest on the podcast. Her book, Accidental Demons is featured on People Magazine's top ten book gift suggestions for this year! Whether you're looking for books about winter and the holidays, a primer on some of this year's buzziest musicians and characters or that "one more chapter" kind of bedtime favorite, there's sure to be a book out there to suit their taste. Bernadette Crowley, also known as Ber, comes from a long line of witches. When Ber is diagnosed with diabetes, however, she learns that every time she tests her blood sugar, demons accidentally slip into the human dimension — and it's up to Ber and her sister, Maeve, to stop them. This fantastical book is a great escape for young readers over holiday break. Buy Now Top ten books https://people.com/kids-gift-book-suggestions-wicked-taylor-swift-books-8752097

TopMedTalk at The American Society of Anesthesiologists (ASA)'s annual general meeting; Anesthesiology 2024. We're bringing you a series of podcasts from the conference. Make sure you check our podcast feed and are subscribed to TopMedTalk, as we are currently releasing episodes more often than usual to accommodate high demand. This piece provides much needed focus on the topic of pediatrics and hemodynamics. Is it true to say that children are completely different to adults? What information do we need and what should the considerations around this topic really be? Presented by Desiree Chappell and Mike Grocott with their guests Dwight Bailey, Chief, Division of Pediatric Critical Care Medicine at Atrium Health, Levine Children's Hospital and Jonathan Tan, Vice Chair of Analytics and Clinical Effectiveness, Department of Anesthesiology Critical Care Medicine, Assistant Professor of Clinical Anesthesiology and Spatial Sciences, Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Spatial Sciences Institute of the University of Southern California

In this episode, hosts Dr. Kevin Chu and Dr. Justin Dubin engage in a timely discussion about the evolving landscape of male birth control options. With limited access to abortion services in many states, the need for men to take responsibility in family planning has never been more crucial. The hosts welcome Dr. Brian Nguyen, a leading expert in complex family planning and associate professor at the Keck School of Medicine at USC. Dr. Nguyen shares valuable insights into the promising developments in male contraceptives currently in clinical trials, emphasizing the importance of providing men with effective, temporary options. While the hosts advocate for vasectomies as a permanent solution for those who no longer wish to have children, they recognize that not everyone is ready for that step. They discuss the potential of various innovative methods, including the role of testosterone as a male contraceptive, and clarify common misconceptions about male fertility while on testosterone therapy. Learn more about the significance of expanding contraceptive options for men and how this can positively impact family planning. Tune in now on Spotify, Apple Podcasts, Amazon, and YouTube! #podcast #menshealth #fertility #contraceptive #reproductivehealth #healthcare #optimalwellness #men #wellness

In this episode of AI @ HLTH on The Beat, Sandy Vance speaks with Dr. Benjamin Nguyen from Transcarent about the innovative Wayfinding platform, which integrates AI to enhance healthcare navigation for employees. They discuss the challenges of healthcare engagement, the importance of personalized experiences, and the role of AI and LLMs in transforming healthcare delivery. Dr. Nguyen emphasizes the need for privacy and security in healthcare AI solutions and shares insights on the future of AI in the industry.In this Episode they discuss:Employees deserve benefits that empower them with guidance.Transcarent aims to simplify healthcare navigation.Wayfinding connects various healthcare solutions in one platform.Healthcare complexity leads to disengagement among employees.AI can provide personalized healthcare experiences.LLMs enhance engagement by tailoring responses to individuals.Privacy and security are paramount in healthcare AI.Transcarent does not train LLMs on customer data.The future of healthcare will see more subtle AI integration.Investing in innovative solutions is key for employers.A little about Dr. Benjamin Nguyen: Dr. Benjamin (Ben) Nguyen, M.D. is a healthcare and AI product leader. At Transcarent, Dr. Nguyen currently leads the Transcarent AI team which is tasked with expanding Transcarent's suite of AI products while maintaining the highest standards for patient safety. Throughout his career, Dr. Nguyen has led multiple teams building AI products ranging from hospital AI deployment platforms, radiology AI safety applications, chatbots for patients, and AI tools for clinicians. Dr. Nguyen is known as an expert on AI in healthcare, and was recently called to testify before Congress on the subject, educating lawmakers and the public about the potential and safety risks of AI. He is also a guest lecturer at the University of Southern California, where he teaches about AI fundamentals and safety in healthcare. Dr. Nguyen received his Doctor of Medicine degree at the Keck School of Medicine of USC, as well as graduate specialization certificates from the Marshall School of Business and the Viterbi School of Engineering. He is a Bay Area native and lives in San Francisco, California.

What if the future of cardiac care meant shorter duration of dual antiplatelet therapy without compromising safety? Join us as we explore this possibility with Dr. Joseph Szokol, a leading expert in clinical anesthesiology at the Keck School of Medicine of USC. Dr. Szokol shares his insights into the revolutionary advancements in drug-eluting stent technology, which are reshaping how we approach perioperative care and patient safety. With over 600,000 cardiac stents placed each year, this episode is a must-listen for understanding the evolving landscape and its implications for anesthesia professionals.Reflecting on past challenges, we transport you back to insights from the 2009 APSF newsletter that spotlighted the critical risks of stent thrombosis associated with older stent technologies. Discover how recommendations have dramatically shifted—from urging a 12-month delay for elective surgeries post-stent placement to adapting to breakthroughs in new generation stents. With a compelling narrative filled with historical context and cutting-edge research, this episode equips listeners with vital knowledge and updated guidelines that could significantly enhance perioperative patient management and safety.For show notes & transcript, visit our episode page at apsf.org: https://www.apsf.org/podcast/228-the-journey-of-drug-eluting-stents-and-anesthesia-patient-safety/© 2024, The Anesthesia Patient Safety Foundation

Send us a text In this episode of Causes or Cures, Dr. Eeks sits down with Dr. Hooman Allayee and James Hilser to explore their new research on the lasting impact of COVID-19 on heart health. They reveal surprising findings about how COVID—especially in those who were hospitalized—elevates the risk of severe heart issues long after recovery, even years down the road. The conversation dives into the connection between blood type and post-COVID heart risk, and the researchers share their theories on why blood type matters. Plus, they discuss the implications of these findings for public health and clinical practice, offering important recommendations for how the public health and medical community should respond. Dr. Allayee is a professor of populations and public health sciences and biochemistry and molecular medicine at the Keck School of Medicine of USC. His research focuses on utilizing genetics and genomics to better understand complex cardiovascular, metabolic, and inflammatory diseases. James Hilser holds a masters of public health, is a bioinformatics specialist and a PhD candidate in molecular medicine in the Department of Population and Public Health Sciences at Keck School of Medicine. *New* SUBSCRIBE for Causes or Cures+ Bonus Episodes!You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the show

Dr. Troy McEachron joined us on OsteoBites to discuss the molecular and cellular deconstruction of metastatic osteosarcoma. Immunotherapy holds great promise for a subset of patients whose tumors respond to this innovative and remarkable approach. The therapeutic benefit for patients with osteosarcoma has been largely underwhelming, prompting clinical, translational, and basic scientists to ask why. Dr. McEachron's laboratory is focused on understanding the oncogenic and immunoregulatory mechanisms within the metastatic osteosarcoma microenvironment and how they impact therapeutic efficacy. He discusses his lab's current work in using various -omic technologies to deconstruct metastatic osteosarcoma.Dr. McEachron earned his doctorate in Molecular and Cellular Pathology from the University of North Carolina at Chapel Hill in 2011. He completed postdoctoral fellowships at St. Jude Children's Research Hospital and at the Translational Genomics Research Institute. In 2016, Dr. McEachron joined the faculty of the Keck School of Medicine at the University of Southern California as an Assistant Professor in the Department of Translational Genomics (primary appointment) and the Department of Pediatrics (secondary appointment). Dr. McEachron joined the Pediatric Oncology Branch of the National Cancer Institute in 2021 where he leads the Integrated Solid Tumor Biology Section. The major focus of his laboratory is to molecularly dissect the microenvironment of pediatric metastatic osteosarcoma to better understand the biology of metastatic disease and identify therapeutically actionable targets.

Welcome to This Week in Pharmacy where we touch base on Pharmacy Times Reports on "Community Pharmacy's Existential Question: Should you Chase Product Revenues or Service Margins by Troy Trygstag PharmD. We talk about the Ohio Capital article on PBMs skimming millions of dollars from tax-payers, and Forbes reports on Mark Cuban Cost Plus Drugs is disrupting the PBM contracts and their work with Blue Shield of California. Big time news!!  Let's talk about Wound Care on This Week in Pharmacy: William Padula, PhD from the Alfred E. Mann School of Pharmacy & Pharmaceutical Sciences and-or David G. Armstrong MD from the Keck School of Medicine of USC, are talking with Todd Eury on TWIRx about a recent proposal from Medicare is calling to  eliminate coverage of some of skin substitute therapies, and the potential serious health risks that many Americans will face by limiting them. Skin substitutes, made from donated amniotic tissue, greatly improve wound care outcomes and help patients avoid limb amputations—a procedure that can double the risk of death for diabetic patients. This Medicare proposal under consideration will deny coverage of over 200 skin substitutes and limit how doctors can properly treat patients will leave tens of thousands of Medicare beneficiaries without treatment.

Can AI diagnose mental illness? How will technology change pediatricians in the future? How is AI used in medical documentation? Who can diagnose autism in a child? Our guest is Colleen Kraft, MD, MBA, past president of the American Academy of Pediatrics, a practicing pediatrician, and a Professor of Pediatrics at the Keck School of Medicine of the University of Southern California. American Medical Association CXO Todd Unger hosts.

Dr Dan Dworkis is a board-certified emergency physician and Adjunct Professor at the Keck School of Medicine at the University of Southern California. He is Chief Medical Officer at the Mission Critical Team Institute. His book The Emergency Mind: Wiring Your Brain for Performance Under Pressure was published in 2021. In this conversation we explore what it means to deal with uncertainty in situations of crisis. https://keck.usc.edu/faculty-search/daniel-dworkis/

Sarah Hill, professor of social psychology at Texas Christian University and author of This is your brain on birth control: The surprising science of sex, women, hormones and the law of unintended consequences, shares her journey into exploring the effects of oral contraception on mental health.  “I actually spent my early career studying the way our sex hormones can affect psychological states and motivation…and the desire to attract romantic partners.” It wasn’t until Hill went off oral contraception herself that she began to connect the dots. “I started to feel so differently, that I started to really wonder what we did not know and about the way the pill affects the brain and the way that women experience the world.” Hill recounts  her personal experience and the research she conducted on the Pill’s effects, highlighting a range of impact on physical and mental wellbeing. Everything from “having less energy” to “being at a greater risk for depression and anxiety,” and how “it can reduce sexual desire and sexual functioning.” Emily Dossett, a clinical associate professor of Psychiatry & the Behavioral Sciences at USC’s  Keck School of Medicine, addresses another often-overlooked aspect of  women’s health: the prevalence of mental health disorders before, during, and after pregnancy. Dossett underscores  that “pregnancy is a time of tremendous and rapid physiological change,” and that “if a woman is susceptible, really to anything; diabetes, hypertension, cardiac disorders,” that pregnancies with those disorders “are more likely to come to the forefront or even emerge for the first time. The same is true for mental illness.” Dossetts points out  that society tends to attach  immense  joy to pregnancy and the celebration of pregnancy that women feel ashamed, even stigmatized, if they mention or complain about how they feel. “We're just realizing how common some of these challenges are in terms of mental health because we're just now at a point where we're allowing women to actually speak up about it.” Roughly “one out of every four to five women” suffer from some kind of mental disorder, Dossett says, with depression and  anxiety being most common.    Because there has been little research on women’s mental health and pregnancy, Dossestt explains that there’s a general “lack of understanding and comprehension and naming of these disorders in the mental health world.” And when it comes to medication; “ the FDA, which approves all drugs, does not permit pregnant or lactating people to be included in drug trials.” So, what options are available for  women who require medication and aspire to conceive? “The question is not really whether or not these medications are safe but it's more of a risk, risk analysis for each individual person,” Dossett says.   “I firmly believe everyone has the right to have a child. Everyone has the right to not have a child and everyone has the right to raise a child in a safe and healthy environment. Those are the tenets of what we call reproductive justice. And I believe they apply to people with mental illness just like anyone else.”  Delve deeper into life, philosophy, and what makes us human by joining the Life Examined discussion group on Facebook.

In this podcast, hear expert perspectives on practice-changing advances in the treatment and personalized management of patients with hemophilia from Dr. Guy Young, Director of the Hemostasis and Thrombosis Program, Attending Physician in Hematology/Oncology, and Professor of Pediatrics at Keck School of Medicine of USC; and Dr. Jennifer Davila, Co-Director of the Hemophilia Treatment Center at Montefiore and Associate Professor of Pediatrics at The Children's Hospital at Montefiore. Listen to the episode now! Click here to claim your free CME/NCPD credit for this activity: https://bit.ly/4eQSbaL

In this episode, hosts Drs. Peter Lu and Temara Hajjat talk to Dr. Tanaz Danialifar about diagnosing and treating disaccharidase deficiencies in children, including lactase deficiency and congenital sucrase-isomaltase deficiency (CSID). Dr. Danialifar is a pediatric gastroenterologist at Children's Hospital Los Angeles, where she is Associate Director of their Gastroenterology Fellowship Program, and an Assistant Professor at the Keck School of Medicine of USC.Learning Objectives:Recognize aspects of a child's clinical presentation that would raise concern for a disaccharidase deficiency.Understand the roles of the various diagnostic tests available for disaccharidase deficiencies.Understand the treatment and prognosis of disaccharidase deficiencies in children.Support the Show.This episode is eligible for CME credit! Once you have listened to the episode, click this link to claim your credit. Credit is available to NASPGHAN members (if you are not a member, you should probably sign up). And thank you to the NASPGHAN Professional Education Committee for their review!As always, the discussion, views, and recommendations in this podcast are the sole responsibility of the hosts and guests and are subject to change over time with advances in the field.Check out our merch website!Follow us on Twitter, Facebook and Instagram for all the latest news and upcoming episodes.Click here to support the show.

Vaping. It seems to be everywhere these days. Sure, adults engage in vaping but, sadly, so do adolescents and even children at very high numbers. There have been all kinds of myths as they relate to vaping and, as always, it is crucial to listen to the experts who know the science. One such person is Dr. Adam Leventhal (https://keck.usc.edu/faculty-search/adam-matthew-leventhal/). Adam is a professor at Keck School of Medicine at USC where he serves as Professor of Population and Public Health Sciences as well as the Director of the Institute for Addiction Science.As his title suggests, he's the guy from whom I would want to learn and I am so grateful he shared his knowledge.So, listen in as Adam and Adam talk about vaping, the myths and realities.

While Alzheimer's disease isn't curable, research shows it may be preventable or postponable by controlling lifestyle factors like diet. Yet, with so many types of diets emerging, it's hard to know what's a fad and what lifestyle changes can actually support brain health. USC's Dr. Hussein Yassine joins Being Patient live talks to answer questions about how diet affects brain health. Yassine is an associate professor at USC's Keck School of Medicine. His research is focused on the intersection of neurology and nutritional sciences. At Yassine Lab, his team studies how lipids — particularly omega-3 fatty acids — affect Alzheimer's disease. He's also the director of USC Center for Personalized Brain Health, launched in 2023 to build research on the APOE gene and the role of fatty acids in the brain to advance personalized health to cut Alzheimer's risk. Watch this live talk to learn more about how diet impacts the brain and, ultimately, Alzheimer's risk.

This piece is part of our coverage of The International Anesthesia Research Society (IARS) annual meeting. Here our guest discusses his dual roles in patient safety and quality improvement and his research in spatial sciences; focusing on how environmental and social factors impact health. Can the integration of environmental data into electronic health records allow us to better understand and address health determinants like air quality? What are the practical applications for healthcare providers? Presented by Desiree Chappell, TopMedTalk co-editor in Chief and Monty Mythen, TopMedTalk's founder, with their guest Jonathan Tan, Vice Chair of Analytics and Clinical Effectiveness, Department of Anesthesiology Critical Care Medicine, Assistant Professor of Clinical Anesthesiology and Spatial Sciences, Keck School of Medicine of USC.

On this week's episode of the Escape Your Limits podcast, we are joined by Dr. Rand McCain, aka ‘The Longevity Doctor' to explore whether death is predetermined by genetics or whether we can make informed lifestyle choices that extend health span and override the influence of our genes. Dr. McClain earned his medical degree at Western University and completed his internship at the University of Southern California's Keck School of Medicine Residency Program (U.S.C. California Hospital) and has spent his professional life redefining what it means to be in optimal health. Having established his own practice, Regenerative and Sports Medicine Dr. McClain supports his patients (many of which are A-List celebrities and world-class athletes) through the application of cutting edge treatments and philosophies including bioidentical hormone replacement therapy (BHRT), hyperbaric oxygen therapy, cryotherapy, platelet rich plasma and stem cell therapies.  In his recent book, ‘Cheating Death: The New Science of Living Longer and Better', Dr. McClain reveals fresh, science-backed approach to genetics, natural aging, and proactive medical treatments and discusses how to access to these therapies to jumpstart their body's regenerative processes. Bolstered with research and recovery stories from real people, Cheating Death gives readers the tools to live healthier, longer lives.  In this podcast, Dr. McClain talks extensively about: ●       Fitness trends and nutrition principles past and present. ●       Biological age versus Chronological age. ●       Key bio markers for predicting healthy longevity. ●       Anti-aging supplements. ●       The effect of NAD on energy and sleep. ●       Polyphenols and their role in fighting inflammation and cancer. ●       Sleep hygiene habits. ●       Cold Therapy and heat shock proteins to boost health. ●       Air quality's impact on health. ●       Testosterone replacement therapy. Debunking myths. ●       Fasting and its effects on cortisol.       The role of genetics  and emerging tech in a long and healthy life.   To learn more about Dr. Rand McClain, click here: https://drrandmcclain.com/ https://psrmed.com/ ====================================================== Subscribe to our YouTube channel and turn on your notifications so you never miss a new video when it's published: https://www.youtube.com/user/EscapeFitness Shop gym equipment: https://escapefitness.com/shop View our full catalog:  https://escapefitness.com/support/catalog https://escapefitness.com/support/catalogue  ====================================================== Facebook: https://www.facebook.com/Escapefitness Instagram: https://www.instagram.com/escapefitness Twitter: https://www.twitter.com/escapefitness LinkedIn: https://www.linkedin.com/company/escapefitness/ 0:00       Intro 0:33       Weightlifting for performance and aesthetics 2:38       The impact Schwarzenegger had on bodybuilding 3:53       Fitness trends and nutrition principles past and present 7:41       Verify the source: don't believe everything you see or read 13:06    The misconception that body building icons are in competition shape 12 months of the year 17:26    The inspiration behind the book ‘Cheating Death' 19:06    Biological age versus chronological  age 24:58    Key bio markers for predicting healthy longevity 38:26    Anti-aging supplements, including vitamin D3 and B 42:33    The effect of NAD on energy and sleep 46:06    Poly phenols and their potential to fight inflammation and cancer 49:07    Creating good sleep hygiene habits 56:52    The effects of growth hormones on sleep 1:00:05 Cold Therapy and heat shock proteins to improve blood flow and general health 1:02:40 Air quality's impact on health, with a focus on nitric oxide and its benefits 1:10:09 Testosterone replacement therapy and the risks 1:24:00 The effects of fasting on cortisol 1:30:52 The role of genetics in a long and healthy life 1:35:40 Emerging tech and therapies that will significantly impact health span 1:38:46 Regenerating nerves and recovering from paralysis using stem cells

In this episode we talk about the bias and stigma around women and sexual health and particular what his looks like for Muslim  women.  We talk about religious, culture and family views as well as societal taboos around sexual health.Dr. Rahman is a board-certified OB/GYN who has tailored her practice to meet the needs of women for gynecologic and cosmetic services. After years of practicing obstetrics and gynecology in a variety of large academic settings and locations, Dr. Rahman started her own practice to focus on her special areas of interest to ensure patients have their best quality of life. Through her research and dedication, she is one of the few physicians nationally to receive the designation of ISSWSH (International Society for the Study of Women's Sexual Health ) Fellow (IF) and is actively involved with cutting edge approaches to sexual pain and sexual dysfunction. She also is an active member of the IPPS, International Pelvic Pain Society, and specializes in a multidisciplinary approach to chronic pelvic pain. For midlife women, Dr. Rahman is also a specialist in menopause management with the designation of Certified Menopause Physician through the North American Menopause Society (NCMP).Dr. Rahman was raised in the south in North Carolina and as you will see from her rapport, she understands what good ole southern hospitality means. She attended Duke University for her B.S. degree in Biology where she also specialized in Women's Studies. She then continued in her home state at the University of North Carolina at Chapel Hill for her M.D. As women's health care and women's issues have always been on the forefront of concerns for her, she moved up north for her residency in Massachusetts in Obstetrics and Gynecology at the University of Massachusetts. After completing her residency, she made her way out west to Los Angeles, California where she spent four years on the faculty at the University of Southern California, Keck School of Medicine . In L.A., she spent a great deal of her time on resident and medical student education and simulation training in obstetrics and surgery. She also spent her personal time performing medical missions internationally with a variety of international women's organizations as well as working with at the WHO in Switzerland.She has taken extra time to explore areas of aesthetic medicine with the American Board of Aesthetic Medicine, including anti-aging and laser technology and improving sexual health through additional work in aesthetic vaginal procedures in southern California.Currently, Dr. Rahman is a Clinical Assistant Professor of OB/GYN at the Northwestern Feinberg School of Medicine in downtown Chicago. She previously worked at Northshore University Health Systems and was on the faculty at the University of Chicago. She is a member of the American Congress of Obstetricians and Gynecologists and American College of Aesthetic and Cosmetic Physicians and a Fellow of The American College of Obstetrics and Gynecology.With her experience and expertise, she decided to venture on her own opening the Center for Gynecology and Cosmetics and tailors her practice to your needs!In her spare time, she enjoys spending time with her children and family, running outdoors no matter the season, and traveling with her children in tow. To Follow US check out: Dr. Rahman- @gynogirlhttps://www.cgcchicago.com/Heather- www.theshowcenter.comJackie- https://www.mymonarchhealthco.comThe podcast- @justaskhiveHeather- @showcenterdrqJackie- @jackiep_gynnpMenopause and Midlife Course The course is live and available at:the-hive8.teachable.com

Advances in Alzheimer's disease clinical trials are accelerating rapidly, leading to new insights and disease-modifying therapies, but how does the field continue bolstering that momentum? For Dr. Rema Raman, it's through improving inclusivity and training for early-career researchers. Recorded at the 2024 Alzheimer's Disease & Related Dementias Research Day, Dr. Raman joins the podcast to discuss her work in research recruitment and retention, the importance of training the next generation of clinical trialists in dementia research with the IMPACT-AD program and more from her featured presentation. Guest: Rema Raman, PhD, co-director, Institute of Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD), director, section of biostatistics, section of participant recruitment & retention section, Alzheimer's Therapeutic Research Institute, professor of neurology, University of Southern California Show Notes Watch our YouTube page for upcoming recordings of Dr. Raman's presentation and other featured speakers at Alzheimer's Disease & Related Dementias Research Day 2024. Learn more about Alzheimer's Disease & Related Dementias Research Day on our website. Learn more about the Institute of Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD) on their website. Learn more about Dr. Raman at her bio on the Keck School of Medicine website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter. Enjoy Dementia Matters? Consider making a gift to the Dementia Matters fund through the UW Initiative to End Alzheimer's. All donations go toward outreach and production.

In today's episode, Dr. Rachael Forsythe (@ROForsythe), consultant vascular surgeon at NHS Lothian, leads a fictional case-based discussion with leaders in managing diabetic foot ulcers. Joining the conversation are Professor Andrew Boulton, Mr. Patrick Coughlin, Dr. David Armstrong, Dr. Dane Wukich, and Dr. Edgar Peters. Professor Boulton is a professor of medicine at Manchester University in England and is co-chair of the Malvern  Diabetic Foot Conference meeting. He served as president of numerous distinguished societies, including the International Diabetes Federation. Dr.  Coughlin (@Coughlin_pa) is a consultant vascular surgeon in Leeds, England. He is a very active member of the Vascular Society of Great Britain and Ireland Council and has a special academic and clinical interest in peripheral artery disease. Dr. Armstrong (@DGArmstrong) is a podiatric surgeon and professor of surgery at Keck School of Medicine of the University of California and director of the Southwestern Academic Limb Salvage Alliance. Dr. Armstrong is very well known for his work on amputation prevention, the diabetic foot and wound healing. Dr. Wukich (@DaneWukich) is a professor and chair of the Department of Orthopedics at the University of Texas, Southwestern and Medical Director of Orthopedic Surgery at UT Southwestern University Hospitals. Dr. Wich has an interest in foot and ankle surgery, including the management of diabetes-related complications. Dr. Edgar Peters is an associate professor of internal medicine, infectious diseases, and acute medicine at Amsterdam University Medical Centers, Dr. Peter's main interest is infection of the musculoskeletal system, particularly in patients with diabetes and is the Scientific Secretary of the International Symposium on the Diabetic Foot.    Malvern Diabetic Foot Conference info: https://www.facebook.com/MalvernDiabeticFootConference/ https://eu.eventscloud.com/website/8151/   If this episode was of interest to you, please take a listen to this Transatlantic Series episode where we speak with the authors of the SVS, ESVS, and IWGDFU joint guidelines on the management of peripheral arterial disease (PAD) in patients with diabetes.    Articles, resources, and societies referenced in the episode: DF Blog. “Oral Is the New IV. Challenging Decades of Blood and Bone Infection Dogma: A Systematic Review @bradspellberg @lacuscmedcenter @usc,” January 1, 2022. https://diabeticfootonline.com/2022/01/01/oral-is-the-new-iv-challenging-decades-of-blood-and-bone-infection-dogma-a-systematic-review-bradspellberg-lacuscmedcenter-usc/. Gariani, Karim, Truong-Thanh Pham, Benjamin Kressmann, François R Jornayvaz, Giacomo Gastaldi, Dimitrios Stafylakis, Jacques Philippe, Benjamin A Lipsky, and Lker Uçkay. “Three Weeks Versus Six Weeks of Antibiotic Therapy for Diabetic Foot Osteomyelitis: A Prospective, Randomized, Noninferiority Pilot Trial.” Clinical Infectious Diseases 73, no. 7 (October 5, 2021): e1539–45. https://doi.org/10.1093/cid/ciaa1758. Li, Ho-Kwong, Ines Rombach, Rhea Zambellas, A. Sarah Walker, Martin A. McNally, Bridget L. Atkins, Benjamin A. Lipsky, et al. “Oral versus Intravenous Antibiotics for Bone and Joint Infection.” New England Journal of Medicine 380, no. 5 (January 31, 2019): 425–36. https://doi.org/10.1056/NEJMoa1710926. Magliano, Dianna, and Edward J. Boyko. IDF Diabetes Atlas. 10th edition. Brussels: International Diabetes Federation, 2021. Østergaard, Lauge, Mia Marie Pries-Heje, Rasmus Bo Hasselbalch, Magnus Rasmussen, Per Åkesson, Robert Horvath, Jonas Povlsen, et al. “Accelerated Treatment of Endocarditis—The POET II Trial: Ration ale and Design of a Randomized Controlled Trial.” American Heart Journal 227 (September 2020): 40–46. https://doi.org/10.1016/j.ahj.2020.05.012. Price, Patricia. “The Diabetic Foot: Quality of Life.” Clinical Infectious Diseases 39 (2004): S129–31. Sharma, S., C. Kerry, H. Atkins, and G. Rayman. “The Ipswich Touch Test: A Simple and Novel Method to Screen Patients with Diabetes at Home for Increased Risk of Foot Ulceration.” Diabetic Medicine: A Journal of the British Diabetic Association 31, no. 9 (September 2014): 1100–1103. https://doi.org/10.1111/dme.12450. Shin, Laura, Frank L. Bowling, David G. Armstrong, and Andrew J.M. Boulton. “Saving the Diabetic Foot During the COVID-19 Pandemic: A Tale of Two Cities.” Diabetes Care 43, no. 8 (August 1, 2020): 1704–9. https://doi.org/10.2337/dc20-1176. Tone, Alina, Sophie Nguyen, Fabrice Devemy, Hélène Topolinski, Michel Valette, Marie Cazaubiel, Armelle Fayard, Éric Beltrand, Christine Lemaire, and Éric Senneville. “Six-Week Versus Twelve-Week Antibiotic Therapy for Nonsurgically Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study.” Diabetes Care 38, no. 2 (February 1, 2015): 302–7. https://doi.org/10.2337/dc14-1514. Wukich, Dane K., Katherine M. Raspovic, and Natalie C. Suder. “Patients With Diabetic Foot Disease Fear Major Lower-Extremity Amputation More Than Death.” Foot & Ankle Specialist 11, no. 1 (February 2018): 17–21. https://doi.org/10.1177/1938640017694722.

Discussion with Dr. Joseph Thomas Patterson, Assistant Professor of Clinical Orthopaedic Surgery at the Keck School of Medicine of the University of Southern California on the VANCO Trial. Specifically, we discuss his paper in the January issue of the Journal of Orthopaedic Trauma entitled “The VANCO Trial Findings are Generalizable to a North American Trauma […]

It's 2024, and the opioid crisis is showing no signs of slowing down. Overdose deaths from opioids, including prescription painkillers and synthetics like fentanyl, continue to rise. The statistics paint a chilling picture.  According to the CDC, an estimated 187 people in the U.S. die every day of opioid overdoses, most involving illicit and dangerous versions of fentanyl.  What's perhaps more alarming, is this crisis is now affecting every age group. In fact, overdose is now the third leading cause of death in American children. From 2019 to 2021, adolescent overdose deaths more than doubled. To help us better understand the crisis, Dr. Ricky Bluthenthal is on the show today. At the University of Southern California, Dr. Bluthenthal is a Professor and Vice Chair for Diversity, Equity and Inclusion in the Department of Populations and Public Health Sciences, and Associate Dean for Social Justice in the Keck School of Medicine. He's well versed on the opioid crisis and its devastating effects on families and communities. He's been published more than 190 times in peer-reviewed scientific journals and is on the editorial board of the International Journal of Drug Policy. Dr. Bluthenthal has received numerous awards including the John P. McGovern Award for Excellence in Medical Education from the Association for Multidisciplinary Education & Research in Substance Use & Addiction. On this episode, he joins to give us more insight on the opioid crisis and what he believes needs to happen to make change. EPISODE SHOWNOTES: Read more. BE AFFIRMED. Get the Good Words email series. WHAT'S YOUR CAUSE? Take our quiz. STUDY SCRIPTURE. Get inside the collection. BE INSPIRED. Follow us on Instagram. FIGHT FOR GOOD. Give to The Salvation Army.

In this week's episode of the Fierce Factor podcast, get ready for an extraordinary conversation with Nicola Lowrey, PA-C, the founder & CEO of N2 Aesthetics in Manhattan Beach, CA. Nicola isn't just another industry leader—she's a dynamic force of passion and expertise, particularly in education, anatomy, and safety with injectables. Join us as Nicola shares her journey from graduating with a Masters in Physician Assistant Practice at USC's Keck School of Medicine to becoming one of the most sought-after industry speakers and trainers in the U.S. Nicola's unwavering commitment to sharing her knowledge extends beyond her work as a contributing author to numerous evidence-based anatomical publications. With a robust educational presence on social media, she engages with a sizable and highly active audience, showcasing her relentless dedication to sharing valuable insights and expertise. But it's not just about professional success—Nicola opens up about launching a business during personal turmoil, navigating imposter syndrome, and her profound perspective on facing adversity. She reminds us that integrity and doing things the right way, even when it's tough, are non-negotiable. In this captivating interview, Nicola shares insights on private equity in the aesthetic space, the trajectory of N2 Aesthetics, and her aspirations for thought leadership. Through a collection of powerful stories, she reminds us that "things happen FOR you, not TO you." Tune in to discover why Nicola is a true trailblazer in the world of aesthetics and a true embodiment of the Fierce Factor. Xo, Kaeli Follow Nicola on Instagram Watch the interview on YouTube Purchase your ticket for our upcoming live event: The ALT Experience Book a Strategy Call with Team KLC Subscribe to our Weekly Newsletter, The Blueprint KLC Consulting Website Kaeli on Instagram Kaeli on LinkedIn

My guest today is Dr. Dan Dworkis.  Dan is a board-certified emergency physician, an Assistant Professor of Emergency Medicine at the Keck School of Medicine of USC, the founder of The Emergency Mind Project, and the Chief Medical Officer at the Mission Critical Team Institute. Dan performed his emergency medicine residency with Harvard Medical School at the Harvard Affiliated Emergency Medicine Residency at Massachusetts General Hospital / Brigham Health and holds an MD and PhD in molecular medicine from the Boston University School of Medicine. Dan is the author of The Emergency Mind: Wiring Your Brain for Performance Under Pressure.  He is also the host of The Emergency Mind podcast.   I am excited to have Dan on the debrief because he not only has a unique blend of scientist and practitioner but is someone who has thought very deeply about how our minds work in critical incidents.  Additionally, through his work with Mission Critical Team Institute he has looked at how those principles apply to tactical operators and first responders.    Contact Info: Website: www.emergencymind.comEmail: Dan@emergencymind.comBook: The Emergency Mind: Wiring Your Brain for Performance Under Pressure - Dan Dworkis MD PhD – ISBN13:‎ 979-8746482327Books Recommended: Deep Survival: Who Lives, Who Dies, and Why - Laurence Gonzales - ISBN13: 978-0393052763Meditations - Marcus Aurelius - ISBN13: 978-0812968255

FREE! CRNA School Interview Prep Guide: https://www.cspaedu.com/uc9a5ih4 You can only get yourself as far in your CRNA journey as you allow yourself. Unfortunately, some of us are held back from what we now know as the Impostor Syndrome. It's time we tackle this often overlooked topic and instill more confidence in aspiring CRNAs. Dr. Jeff Darna, CRNA, DNP, and Co-Program Director at Keck School of Medicine of USC joins Dr. Richard Wilson for Episode 7 of the Nurse Anesthesia Educators Unplugged Podcast, a podcast exclusively for CRNA School Prep Academy students. Here's a sneak peek of their discussion as they tackle the topic of Impostor Syndrome, including insights into how it impacts the Healthcare field, including aspiring CRNAs and Nurse Anesthesia Residents, and how to overcome it. Listen to the full episode inside CRNA School Prep Academy today! Join CRNA School Prep Academy for Complete Access to This Episode and the Entire Nurse Anesthesia Educators: Unplugged Library PLUS ALL of the Planning & Application Tools, Interview Prep Tools and More That Have Helped More Than 3,000 Nurses Gain Acceptance Into CRNA School: https://www.crnaschoolprepacademy.com/join Book a mock interview, personal statement, resume and more at https://www.TeachRN.com Join the CSPA email list: https://www.cspaedu.com/podcast-email Send us an email or make a podcast request!Hello@CRNASchoolPrepAcademy.com

Authors:  Sebouh Bazikian - MS4 at Keck School of Medicine of University of Southern California Gowri Gowda - PGY1 at the University of California Davis Integrated Vascular Surgery Program Steven Maximus- Vascular surgery attending at the University of California Davis, Director of the Aortic Center   Resources:  Rutherford's 10th Edition Chapters: 88, 89, and 91 The North American Symptomatic Carotid Endarterectomy Asymptomatic Carotid Atherosclerosis Study Audible Bleeding's eBook chapter on cerebrovascular disease Houston Methodist CEA Dissection Video: Part 1: https://www.youtube.com/watch?v=wZ8PzhwmSXQ Part 2: https://www.youtube.com/watch?v=E_wWpRKBy4w   Outline:  1. Etiology of Carotid Artery Stenosis Risk factors: advanced age, tobacco use, hypertension, diabetes. Atherosclerosis as the primary cause. Development of Atherosclerotic Disease and Plaque Formation LDL accumulation in arterial walls initiating plaque formation. Inflammatory response, macrophage transformation, smooth muscle cell proliferation. Role of turbulent blood flow at carotid bifurcation in plaque development. Clinical Features of Carotid Artery Stenosis Asymptomatic nature in many patients. Symptomatic presentation: Transient ischemic attacks, amaurosis fugax, contralateral weakness/sensory deficit. Carotid bruit as a physical finding, limitations in diagnosis. Importance of Evaluating CAS Assessing stenosis severity and stroke risk. Revascularization benefits dependent on stenosis severity. Classification of Stenosis Levels Clinically significant stenosis: ≥ 50% narrowing. Moderate stenosis: 50%–69% narrowing. Severe stenosis: 70%–99% narrowing. Stroke Risk Associated with Carotid Stenosis Annual stroke rate: ~1% for 50-69% stenosis, 2-3% for 70-99% stenosis. Diagnosis and Screening No population-level screening recommendation. Screening for high-risk individuals as per SVS guidelines. Carotid Duplex Ultrasound as primary diagnostic tool. Additional tools: CT angiography, Magnetic Resonance Angiography. Handling of 100 cm/sec, Internal/Common Carotid peak systolic velocity Ratio > 4. Revascularization Criteria Symptomatic Patients: 50-69% or 70-99% stenosis, life expectancy at least three or two years, respectively. Asymptomatic Patients: 70% stenosis, considering life expectancy. Surgical Indications and Contraindications Indications: symptomatic patients, life expectancy considerations. Contraindications: Stenosis

Show Notes: In this episode of Unleashed, the panel discussion focuses on the pros and cons of becoming an adjunct professor. The panelists discuss the motivations behind teaching courses as an adjunct professor, how to get hired, whether to teach in traditional MBA programs or other certificate or degree programs, the amount of work involved, typical pay, relationship building opportunities, project opportunities, and ancillary benefits such as access to datasets or research services. The discussion kicks off with Adam Braff, a data analytics executive/advisor, shares his reasons for teaching, stating that the best reasons to teach are not practical instrumental reasons but more passion and love for teaching and believes it is a creative act. Mary Kate Scott follows Adam. She teaches at the University of Southern California, Marshall School of Business in the MBA program, and Keck School of Medicine, focusing on healthcare. She has taught the business of healthcare, innovation and health care, new business models in health care, entrepreneurship and health care, and medical device business models. Mary Kate also shares her background with Procter and Gamble and later joined McKinsey for two years to become a better professor. She found she loved the position and stayed there for seven years, but she states that she found the joy of teaching to be both inspirational and fun. She enjoys the level of engagement and interaction in her classes. Sven Beiker teaches Strategy Making in an MBA program at Stanford Business School, and also at a university in Sweden about AI and product development.  He discusses his experience teaching at Stanford and their passion for teaching. He began his teaching career at Stanford which led from a position as an automotive program manager. He also enjoys working with younger people, finding it intellectually stimulating. He has also found the position to be an asset in branding, and has found that it helps in terms of being considered as a keynote speaker from Stanford Business School.    Mohannad Gomaa shares his experience teaching at US Navy PostGraduate School, which was motivated by a contract with a colleague and his subject matter expertise. He designed and delivered the curriculum. He has also taught in consulting colleges, and recently, he was authorized by the Association of Supply Chain Management to teach supply chain certifications, including the CSCP certified supply chain professional certification. This allows him to associate with a reputable knowledge body and meet with stakeholders interested in his work. He has also signed an agreement to be a consulting partner for the ACM, which will allow him to explore more opportunities across industries. He believes teaching is a passion that can generate revenue beyond the passion. An adjunct professor at the University of Copenhagen shares her passion for teaching consulting and adds to her reputation for expertise in her field, but she finds teaching fun and energizing.    How to Secure a Position as an Adjunct Professor The conversation also touches on how to get started as an adjunct professor. To do this, one should be flexible about the institution they want to teach in and focus on the dimensions that are necessary to their field. Many schools have executive MBA programs and masters of leadership programs and other programs  that are growing and need teachers who can teach their specific subject matter area and create and pitch syllabuses. To reach out to the right people in these institutions, one should reach out to the Academic Director of different degree programs. This person will be responsible for the substantive side of these programs and can help with informational interviews. For example, if one wants to teach in New York City, one could reach out to HR or the dean of the school. Mary Kate discusses the benefits of adjunct teaching, including the joy of publications, networking, and credibility. She suggests starting as a guest speaker and gradually delivering classes, either shorter or elective, and eventually creating the curriculum. She also encourages reaching out to people teaching similar courses to your field to get started. She also mentions simply letting people know you are interested in teaching.  Sven mentions that many full-time professors don't like to teach, but they are constantly looking for someone to bring real-world experience into the classroom, to interact with a class, and bring their knowledge to the table. He states that, there are continuing education programs at universities, such as Stanford, that offer continuing education programs on both the professional side of education. These programs can help students gain experience and develop their interest in graduate programs and could be a first step into teaching. Networking is a key aspect of adjunct teaching, and can lead to a board position.  The Evaluation Process Revealed The panelists discussed the typical evaluation process for teaching positions, including the need for specific credentials or certificates, and how to express interest. Having someone internally who can vouch for you can make a difference. The first step in the evaluation process is to have a track record, such as a recording of a lecture, a written syllabus, and student evaluations. This ensures that when applying to another institution, they feel confident in their ability to teach a class.  Compensation for Teaching The compensation for teaching varies between $6,000 for a semester to 15,000, with a median of $10. The time commitment for creating a syllabus from scratch is around 200 hours. There may be additional benefits associated with teaching, such as subsidized healthcare benefits. The panelists discuss the range of compensation, which can range from $1,000 for a 90-minute class to $2,000 for a two-hour class and could for a 7, 12, or 14 week program.  The first time teaching, the teacher takes over the curriculum and develops it, however, they could be writing the entire curriculum, which can be a lot of responsibility but also an opportunity to shape the educational experience for students. It is worth noting that the course can also impact your consulting business, as committing to a class every week can limit your consulting business if you travel frequently. In contrast, in-person classes can be more effective due to scheduling. Another panelist, who is a Professor of Practice at Michigan State University's School of Business, states that the course is a salaried position, but it is not a full-time gig. The pay is based on a W-2 and a salary, which is a relatively small amount. The Benefits of Teaching The conversation revolves around the benefits of teaching and consulting, including inspiration, credibility, and carryover spillover benefits. Mary Kay shares her experience with getting clients and consulting project leads and converting leads into confirmed projects due to her credibility. Her students have become clients, and she concludes that the network is an enormous benefit.  Adam suggests that teaching should be synergistic with consulting work, and that it is synergistic to his writing work and that he has adapted the courses he teaches to corporate training. However, in this situation, it is advised to focus on the language of contracts to ensure that intellectual property rights are portable to a corporate context. Sven shares his experience with gaining project leads, which can be former students who become clients or organizations seeking advice from a professor who is also a consultant, and he has often been asked to be on the advisory board of startups by former students. This nurtures the network and gives the professor more standing and credibility. Clients often recognise the professor's expertise and reputation, making it a valuable asset. Best Practices for Networking Opportunities To maximize networking opportunities, Nick has found partnering opportunities with fellow professors. Mary Kate suggests connecting with other faculty members, attending university events, and partnering with fellow professors. She also shares her experiences of being wasted in the first semester of teaching and finding it difficult to find opportunities to meet with faculty members.  Developing a Curriculum in Academia The conversation turns to the complexity of developing a curriculum in academia. Developing a syllabus can be challenging, especially when it comes to creating evaluation materials and quizzes that can be objective and not lead to low grades. The tension between grades and evaluations can also be a challenge, but it becomes easier after the first time. The complexity of creating a syllabus depends on the type of class, for example, a seminar class at Stanford may require more discussion and bringing in guest lecturers. Another may require more content creation; a new class may require more detailed teaching material, including a reading list, quizzes, preparing exams etc.  Teaching As a Learning Experience Jared Lee, a faculty lecturer at McGill University and principal at Juniper, a Montreal-based consultancy, believes that teaching is a deeper way to learn and develop skills, as it requires a lot of preparation, the ability to defend theories against questions, and to be able to implement storytelling techniques. He believes that teaching 180 students who have detailed questions requires being bulletproof in preparation and how to apply the theories.   Jared also shares that this experience has built his ability in educating clients. Panelists also state that teaching has helped develop stronger public speaking skills, and the ability to manage a crowd. The discussion revolves around the challenges of teaching at universities like Stanford and the importance of facilitation in making discussions meaningful and meaningful. Access to Ancillary Benefits As an Adjunct Professor Additional ancillary benefits include access to datasets, academic journal articles, and other resources. Academic resources, such as the MSU library, are free and can be used in private practice. Academics can also leverage their academic connections to engage in conversations with people for various purposes, such as building lectures for their courses or collaborating on consulting projects. Health insurance is another asset. For example, at McGill, teaching three sections within a year can grant access to health insurance and supplemental pension and investment plans. The conversation ends with the participants discussing their takeaway from the discussion, including:  The importance of 200 hours of syllabus development The importance of fostering meaningful discussions and connections within academia for both students and faculty The importance of passion, preparation, and genuine effort in creating content for a class The need for preparation Staying updated on relevant topics and staying updated on the latest developments Credibility The panelists agreed that you should have good reasons for taking this position, and having a clear purpose for teaching can lead to better results. One additional tip was to be clear about why you are doing it and this will help you focus on how to achieve your goal. Another is to take advantage of a guest lecturer opportunity, and to be open to learning from your students. In conclusion, the panelists discussed the importance of passion, preparation, and genuine effort in creating content for a class. They also highlighted the importance of being proactive, asking questions, and embracing the unique experiences of students. By doing so, teachers can gain valuable insights and develop a deeper understanding of their field. Timestamps: 07:03 Consulting career paths and teaching experience 10:25 Adjunct teaching roles in economics 12:37 Finding teaching opportunities in higher education 15:06 Adjunct teaching opportunities and how to get started 17:24 Teaching at universities, networking, and evaluation processes 24:31 Teaching gigs, compensation, and time commitment 27:07 Teaching and consulting gigs for experts in customer experience management 31:22 Leveraging academic faculty status for consulting opportunities 34:48 Curriculum development and networking at a university 36:42 Teaching methods and challenges in higher education 39:58 Teaching and learning theories in consulting 42:48 Teaching strategies and access to academic resources 45:16 Academic benefits, networking, and health insurance 53:21 Teaching and consulting in academia   Unleashed is produced by Umbrex, which has a mission of connecting independent management consultants with one another, creating opportunities for members to meet, build relationships, and share lessons learned. Learn more at www.umbrex.com.  

The following question refers to Section 9.5 of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. The question is asked by Keck School of Medicine USC medical student & former CardioNerds Intern Hirsh Elhence, answered first by Vanderbilt Cardiology Fellow and CardioNerds Academy Faculty Dr. Breana Hansen, and then by expert faculty Dr. Javed Butler. Dr. Butler is an advanced heart failure and transplant cardiologist, President of the Baylor Scott and White Research Institute, Senior Vice President for the Baylor Scott and White Health, and Distinguished Professor of Medicine at the University of Mississippi The Decipher the Guidelines: 2022 AHA / ACC / HFSA Guideline for The Management of Heart Failure series was developed by the CardioNerds and created in collaboration with the American Heart Association and the Heart Failure Society of America. It was created by 30 trainees spanning college through advanced fellowship under the leadership of CardioNerds Cofounders Dr. Amit Goyal and Dr. Dan Ambinder, with mentorship from Dr. Anu Lala, Dr. Robert Mentz, and Dr. Nancy Sweitzer. We thank Dr. Judy Bezanson and Dr. Elliott Antman for tremendous guidance. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. Question #31 Mrs. Hart is a 70-year-old woman who was admitted to the CICU two days ago for signs and symptoms consistent with cardiogenic shock. Since her admission, she has been on maximal diuretics, requiring greater doses of intravenous dobutamine. Unfortunately, her liver and renal function continue to worsen, and urine output is decreasing. A right heart catheterization reveals elevated biventricular filling pressures with a cardiac index of 1.7 L/min/m2 by the Fick method.   What is the next best step? A Continue current measures and monitor for improvement B Switch from dobutamine to norepinephrine C Place an intra-aortic balloon pump (IABP) D Resume guideline directed medical therapy Answer #31 Explanation The Correct answer is C – Place an intra-aortic balloon pump. This patient is between the SCAI Shock Stages C and D with elevated venous pressures, decreased urine output, and worsening signs of hypoperfusion. She has been started on appropriate therapies, including diuresis and inotropic support. The relevant Class 2a recommendation is that in patients with cardiogenic shock, temporary MCS is reasonable when end-organ function cannot be maintained by pharmacologic means to support cardiac function (LOE B-NR). Thus, the next best step is a form of temporary MCS. IABP is appropriate to help increase coronary perfusion and offload the left ventricle. In fact, for patients who are not rapidly responding to initial shock measures, triage to centers that can provide temporary MCS may be considered to optimize management (Class 2b, LOE C-LD).    The guidelines further state that in patients presenting with cardiogenic shock, placement of a pulmonary arterial line may be considered to define hemodynamic subsets and appropriate management strategies (Class 2B, LOE B-NR). And so, if time allows escalation to MCS should be guided by invasively obtained hemodynamic data via PA catheterization. Several observational experiences have associated PA catheterization use with improved outcomes, particularly in conjunction with short-term MCS. Additionally, PA catheterization is useful when there is diagnostic uncertainty as to the cause of hypotension or end-organ dysfunction, particularly when the patient in shock is not responding to empiric initial measures, such as in this patient. There are additional appropriate measures at this time that are more institution-dependent. An institutional shock team would be very helpful here as they often comprise multidisciplinary teams of heart failure and critical care specialists,