Podcasts about Optogenetics

This study identifies the Median Raphe Nucleus (MRN)

Materials scientist and physicist Guosong Hong is an expert in getting materials to do remarkable things. Recently, he and collaborators used a common food dye found in snack chips to turn living tissue transparent, allowing light to penetrate through skin and muscle. Hong is now working to realize a new age of medical imaging that lets doctors see deep into the body – without surgery. It's a miracle of physics but it could change medicine, Hong tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: ​​Guosong HongGuosong's Lab: THE HONG LABConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Guosong Hong, an expert in physics, material science, and biology from Stanford University.(00:02:52) Material Science Meets NeuroscienceHow Guosong's research blends nanomaterials and brain science.(00:04:01) Why Tissue Isn't TransparentThe challenge of light penetration in biological tissues.(00:05:55) A New Approach to Tissue ClearingThe physics behind tissue transparency and refractive index manipulation.(00:08:57) UV Light and TransparencyHow manipulating UV absorption can align refractive indexes.(00:11:17) First Experiments and ResultsInitial tests that demonstrate successful tissue clearing.(00:13:19) Applications in MedicineThe potential of transparent tissues in dermatology and medical imaging.(00:15:36) Testing on Live TissueThe results of testing transparency techniques on live mice.(00:19:30) Transparency in NatureHow some species have naturally transparent tissue.(00:20:52) Human Eye and Protein TransparencyThe unique proteins that keep our lenses clear using similar physics.(00:23:24) Wireless Light Inside the BodyThe development of ultrasound-activated light sources for tissue imaging.(00:26:56) Precision of Ultrasound LightHow precisely ultrasound can trigger tiny particles to emit light.(00:29:14) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

Renée played this short video https://gregreese.substack.com/p/optogenetics-and-the-secret-worldwide and it needs to go viral all over the world! Optogenetics is a biological technique to control the activity of neurons or other cell types with light.  Renée upgraded her 4 iPhone 11's to flip phones, shortly after the covid hoax started and encourages others to do the same!

JOIN OUR VIP Tribe and Ask Our Experts Your Questions Directly -->DianeKazer.com/VIP DianeKazer.com/NANODETOX Mark's Work --> https://saveusnow.substack.com/ Is your connection to God intact, strong and clear? And how do you know? Are you aware that there has been a concerted, nefarious plan to disconnect us permanently from our God-given source through Optogenetics and 5G Weaponry using the Water, Food Supply, the Vaxx, the Chemtrails and more as the method to destroy? The evil plan with these shots (and much more, including LED street lights, commercial lighting and beyond) is intended with so much more than to simply toxify your body. It has been used to cause TURBO C@NCERS, a myriad of other dis-ease and completely destroy your body, mind and soul connection. This information has been HIGHLY censored from those of us who have been shouting the truth from the rooftops…until now. This is why you're going to want to join us today for a powerful episode of our Warrior Wednesday CHI Podcast with our special guest, 5G Weaponry Expert, Engineer and Inventor, Mark Steele. WE WILL COVER The existential threat of 5G and all Electromagnetic Waves What are Optogenetics? Where are we EXPOSED to Optogenetics and what can we do to limit exposure? Who is most vulnerable to exposure and what is the SOLUTION to those who have been exposed? Why the government attempted to gag Mark Steele in 2018 How Mark discovered that 5G was not introduced for telecommunication How the COVID Vaxx and the 5G WBAN (Wireless Body Area Network) … ? The link between the so-called ‘Climate Emergency' and the CO2 population reduction How to REMEDY the Globalist Genocide agenda with real SOLUTIONS Want to join in on our Afterparty Tribe with SOLUTIONS from our weekly Podcasts? Directly following our Warrior Wednesday CHI podcast we dive straight into our VIP Tribe Mastermind Call (where I'll be guiding all of you on HOW to take action on the topics we'll share in the show). Join our VIP Mastermind Tribe Ministry HERE for only $1 to: Talk to our Expert Mark Steele and ask him directly about 5G Weaponry, how you may be exposed and what you can do to limit your exposure Get VIP only discounts on supplements, DIY courses and more (this ALONE pays for your VIP membership itself) Gain exclusive access to Solutions that Previously were Only Available Via IV Therapy - These Holistic, Natural and Effective remedies will armor you up against 5G and other dangerous and deadly EMFs. But you need to be a VIP member to find out what they are and how they can work for you. REFERENCES OPTOGENETICS https://saveusnow.substack.com/p/the-only-cancer-is-the-criminal-conspirators Mark and Maria Zeee https://rumble.com/v5brw5p-weapons-expert-exposes-smart-city-kill-box-maria-zeee-and-mark-steele-on-in.html 5G Fraud Alert https://www.youtube.com/watch?v=WiAh09Pt-Sc&lc=UgxeKKnT3dlxwAzn7KB4AaABAg.A7xffwTQd-aA8-clVEs7Ai David Icke and Elon - Neurolink Humans https://www.youtube.com/watch?v=EyxdAuw5I4s https://gregreese.substack.com/p/optogenetics-and-the-secret-worldwide?utm_source=podcast-email&publication_id=706779&post_id=150272566&utm_campaign=email-play-on-substack&utm_content=watch_now_button&r=1r1ymw&triedRedirect=true&utm_medium=email

We love to hear from our listeners. Send us a message.Ray Therapeutics' Co-Founder and CEO, Paul Bresge, joins Host Erin Harris to talk about optogenetics and how the company's optogenetics approach differs from other gene therapies on the market developed to restore vision in retinal diseases like retinitis pigmentosa.

JOIN OUR VIP TRIBE FOR ONLY $1 --> DianeKazer.com/VIP BECOME A PATIENT --> DianeKazer.com/CALL --> DianeKazer.com/IMMUNEKIT --> USE WARRIOR10 for 10% OFF Warrior Wednesday CHI Podcast at 10am PT / 1pm ET today for an information-packed episode with my very special guest, Dr Jack Kunkel to cover these BIG questions: Are Spike Proteins Real? And If So, How Do I Protect Myself? What's REALLY Making You Sick? How Do I Arm My Immune System For Optimal Protection? Here at CHI Holistic Health Ministry, we're getting to the root of the questions above and offering you SOLUTIONS to create a strong immune system. Just as healthy roots are imperative to a beautiful, vibrant, blooming tree, I want to see you blossom into the true, natural, and vibrantly healthy beauty that God intended. WE WILL COVER --> Why you need to know what Pleomorphism is…it's more than just a complex word that's actually affecting us on the daily. --> Good Bacteria Vs Bad Bacteria and how this changes within your body --> Are Viruses Real? And What is Their Purpose? --> Can Exercise Be Bad For You? --> How EMF Fields Make You Sick --> Arming Your Immune System for Optimal Immune Function --> Why You Have to Be Properly Testing For Mold, Gluten, Bacteria, Parasites and Other Toxins --> Are you Radioactive? --> Optogenetics and How It Can Control and Monitor You --> You Aren't Pre-Menopausal…Your Hormones Are Off Balance --> Do you have enough healthy flora to sustain a thriving immune system? --> Get ready! Dr Jack Kunkle is joining our VIP Group again! If you're not a VIP member yet…what's stopping you? Join us today for $1 Only Thru July! Prices Go Up August 1st! DianeKazer.com/VIP I love to hear from you! Drop your comments and questions in the chat!

Speakers: Paul Bresge; Eric Daniels, MD and Ethan Rossi, PhD This session discusses optogenetics, a method of endowing non-photoreceptor cells with light-sensing capabilities. This is the most applicable to late-stage patients.

Speakers: Paul Bresge; Eric Daniels, MD and Ethan Rossi, PhD This session discusses optogenetics, a method of endowing non-photoreceptor cells with light-sensing capabilities. This is the most applicable to late-stage patients.

Videos that Woke me Up to Evil • Ted Gunderson Files: https://www.educate-yourself.org/tg/ https://yandex.com/video/search?text=ted+gunderson&from=tabbar • Clinton Chronicles, USA inc runs the drugs: https://archive.org/details/121919clintonchronicles_201912 • Federal Reserve Bank scam: https://topdocumentaryfilms.com/century-enslavement-history-federal-reserve/ https:/ www.theburningplatform.com/2019/01/08/an-idiots-guide-to-the-federal-reserve-scam/ https://www.newstreason.com/post/the-history-of-fractional-reserve-banking-in-america https://archive.org/details/the-money-masters • Cover up of Giants - https://youtu.be/OwYfdS55nj8 VCAST Cover 3 Videos 1. Satanist plan of the Dark Awakening that Russ Dizdar warned about a. But, I wonder if these dark Luciferians (whore, anyplace there is an obelisk) will be destroyed by the 10 Kings and the Anti Christ. b. Mention the use Frequencies – think of Optogenetics and this mind controlism transhumanism tech c. Talks a network of Knights and leaders pushing the agenda – Fortune 500 company logos d. Agenda Playing out with the SEALs e. Georgia Guidestones – 500 M mind controlled slaves f. “New Age Idiots” – mentioned a dark control grid 2. A former luminated one that discloses the genocide agenda a. Evil is provoking the SEALs (dismantling USA) b. White hat magicians = the AC will hate the Whore (dark) – destroy this group with the c. Ten Kings = Tech Companies with one mind.. d. Deagle report – fall of the WEST e. Allowed Invasion of the USA (China military running FEMA camps) 3. A child that grew up in a Satanic coven and sacrificed a companion to Lucifer at an alter. Scripture Used – Endure for 3.5 years as the AC is revealed 7 And I heard the man clothed in linen, which was upon the waters of the river, when he held up his right hand and his left hand unto heaven, and sware by him that liveth for ever that it shall be for a time, times, and an half; and when he shall have accomplished to scatter the power of the holy people, all these things shall be finished. 9 And he said, Go thy way, Daniel: for the words are closed up and sealed till the time of the end. 10 Many shall be purified, and made white, and tried; but the wicked shall do wickedly: and none of the

In this episode of Raising Biotech, Surani explores the fascinating world of vision restoration and optogenetics with Ray Therapeutics. The company raised an oversubscribed $100m Series A in May 2023, which was particularly noteworthy during a extremely grim year for fundraising. Surani speaks with CEO and Co-Founder Paul Bresge about how his daughter's retinitis pigmentosa diagnosis drove him to enter the biotech world. He discusses meeting Co-founder Sean Ainsworth and seeing groundbreaking experiments in blind mice from inventor Dr Zhuo-Hua Pan that lead to the formation of Ray. He also talks about what drew investors to Ray's mission, its clear regulatory path forward (first in retinitis pigmentosa patients followed by Stargardt disease and geographic atrophy) and visions for the company's future. Surani is also joined by renowned optogenetics leader Dr José-Alain Sahel, Distinguished Professor, Department of Ophthalmology, University of Pittsburgh School of Medicine, to talk about Ray's scientific foundations, early data, theoretical safety/efficacy profile and potential to make a meaningful impact in late-stage retinal disorder patients with close to no vision.Timestamps:00:35 - Partner segment: Mindgram.ai01:05 - Background of Ray Therapeutics and focus on late-stage retinal diseases04:30 - CEO Paul Bresge's backstory, personal motivations to enter the biotech world07:30 - Formation of Ray Therapeutics in 2021 with Co-founder and Chairman Sean Ainsworth09:50 - Leveraging breakthrough science from inventor and optogenetics pioneer Dr Zhuo-Hua Pain11:00 - How Ray was able to attract investors and secure an oversubscribed $100m Series A16:40 - Dr José-Alain Sahel gives his take on Ray's early data and scientific potential19:45 - Ray's plans to get the drug into Retinitis Pigmentosa patients and regulatory pathway26:50 - Safety benchmarks and meaningful efficacy outcome measures38:20 - Optogenetics competitive landscape and Ray's potential edge29:00 - Future financing goals and the company's longer term visionThis episode is partnered with Mindgram.ai, a research tool powered by AI to better serve the biopharma community. Listeners of the Raising Biotech podcast are able to get an exclusive free trial of Mindgram via this link, using the code: raisingbiotech24For any comments, questions, feedback or suggestions you can connect directly with Surani Fernando on LinkedIn or email: raisingbiotech@gmail.comMusic composed by: Yrii Semchyshyn (Coma Media) Hosted on Acast. See acast.com/privacy for more information.

In this episode, my guest is Dr. Diego Bohórquez, PhD, professor of medicine and neurobiology at Duke University and a pioneering researcher into how we use our ‘gut sense.' He describes how your gut communicates to your brain and the rest of your body through hormones and neural connections to shape your thoughts, emotions, and behaviors. He explains how your gut senses a range of features such as temperature, pH, the macro- and micronutrients in our foods, and much more and signals that information to the brain to affect our food preferences, aversions, and cravings. Dr. Bohórquez describes his early life in the Amazon jungle and how exposure to traditional agriculture inspired his unique expertise combining nutrition, gastrointestinal physiology, and neuroscience. We discuss how the gut and brain integrate sensory cues, leading to our intuitive “gut sense” about food, people, and situations. This episode provides a scientific perspective into your gut sense to help you make better food choices and, indeed, to support better decision-making in all of life. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Timestamps 00:00:00 Dr. Diego Bohórquez 00:02:37 Sponsors: Joovv, LMNT & Helix Sleep; YouTube, Spotify & Apple Subscribe 00:06:49 Gut-Brain Axis 00:11:35 Gut Sensing, Hormones 00:15:26 Green Fluorescent Protein; Neuropod Cells & Environment Sensing 00:26:57 Brain & Gut Connection, Experimental Tools & Rabies Virus 00:35:28 Sponsor: AG1 00:37:00 Neuropod Cells & Nutrient Sensing 00:43:55 Gastric Bypass Surgery, Cravings & Food Choice 00:51:14 Optogenetics; Sugar Preference & Neuropod Cells 01:00:29 Gut-Brain Disorders, Irritable Bowel Syndrome 01:03:03 Sponsor: InsideTracker 01:04:04 Gut & Behavior; Gastric Bypass, Cravings & Alcohol 01:07:38 GLP-1, Ozempic, Neuropod Cells 01:11:46 Food Preference & Gut-Brain Axis, Protein 01:21:35 Protein & Sugar, Agriculture & ‘Three Sisters' 01:25:16 Childhood, Military School; Academics, Nutrition & Nervous System 01:36:15 Plant Wisdom, Agriculture, Indigenous People 01:41:48 Evolution of Food Choices; Learning from Plants 01:48:15 Plant-Based Medicines; Amazonia, Guayusa Ritual & Chonta Palm 01:56:58 Yerba Mate, Chocolate, Guayusa 02:00:22 Brain, Gut & Sensory Integration; Variability 02:06:01 Electrical Patterns in Gut & Brain, “Hangry” 02:12:43 Gut Intuition, Food & Bonding; Subconscious & Superstition 02:22:00 Vagus Nerve & Learning, Humming 02:26:46 Digestive System & Memory; Body Sensing 02:32:51 Listening to the Body, Meditation 02:40:12 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter Disclaimer

Fourth Beast System is Mind Controlism – Darpa is studying it Optogenetics is a biological technique that involves the combination of optics and genetics to control the activity of neurons or other cell types with light. This is achieved by expressing light-sensitive ion channels, pumps, or enzymes specifically in the target cells. The technique allows researchers to use light to turn cells on or off with remarkable precision and resolution, even down to individual cells or regions of cells, in living, freely moving animals. As a result, it can be used not only to control specific behaviors in animals, such as triggering or blocking fear or pain responses, but also to deduce the contributions of individual cells to those behaviors. Optogenetics has been used for studying not only the brain but also cardiac tissue, stem cells, and the development of organisms. Able to get a Mouse to kill As for the study where they could get a mouse to kill on demand using optogenetics, researchers at Yale University discovered that two sets of neurons in the mouse brain underpin the instinct to kill3. One set coordinates the pursuit of prey, while the other controls the neck and jaw muscles used for biting3. Both are in the amygdala, the part of the brain involved in motivation, emotion, and fear. By modifying these neurons so they could be activated by laser light, a technique called optogenetics, the team was able to switch these circuits on whenever they wanted. When the laser was off, the mice behaved normally. But when the laser was turned on, the mice launched frenzied attacks on almost anything in their path. This study provides a fascinating insight into the brain circuits that control predatory behavior. However, it's important to note that this research is conducted under controlled laboratory conditions and the ethical implications are carefully considered. Don't Need a brain chip for this mind controlism tech Elon Musk has not made a public statement that Neuralink technology does not require invasive surgery or that you don't have to cut open the brain. We are being divided into camps to ignite a civil war on many fronts.

I talk about how humans could possibly be turned into remote controlled zombies, the sphenoid bone, fascia, and channel rhodopsin gene therapy.  You will learn how the human body can be turned into a photonic computer system controlled by light and how to transcend the madness with healing and play.You are the most powerful technology.  Don't ever forget that.Watch Exclusive Content!https://www.benjosephstewart.com/plans-pricingJoin Our Kickass Discord Community!  https://discord.gg/7QadgxEK4zCheck Out Latest Documentaries -   “Awake In The Darkness” - https://www.aubreymarcus.com/"DMT QUEST" - https://www.youtube.com/watch?v=My95s6ZryPgVisit https://www.BenJosephStewart.com/ to get more involved.Gaia Shows "Psychedelica" & "Limitless" with Free Trial.  https://www.gaia.com/invite/join?rfd=AGvFiE&utm_source=iafLike & Follow, Much Love -Rumble: https://rumble.com/c/c-1044023Minds:  https://www.minds.com/BenJosephStewart/Instagram: https://www.instagram.com/BenJosephStewart/Twitter: https://twitter.com/BenJosephStewBitchute:  https://www.bitchute.com/channel/aanpGqOQt8ZX/TikTok: https://www.tiktok.com/@benstewartofficialTwitch: https://www.twitch.tv/benjosephstewart

Ana Tsai is a PhD student in Biology at MIT from Stockton, California. (0:30) What was your childhood like? (3:25) Growing up with mixed heritage (9:50) Smell of freshly picked tomatoes (11:57) Did you ever imagine becoming a grad student? (15:18) Researching immortality (20:24) What do you do on a daily basis, Zelda protein (24:30) Humans (and fruit flies) are basically a donut (25:10) Optogenetics (28:40) Generalizing from fruit flies to other species (32:00) Setting goals in grad school (34:20) Teaching and connecting with students (42:00) Breaking out of bubbles (51:00) Bees are really cute (55:00) Potlucks with friends (57:15) Where do you see yourself going after grad school? (1:07:00) What would you tell someone who's thinking about going into research?

Nicki Driscoll, PhD is a post-doc researcher at MIT, and CTO of NeuroBionics, a company that has developed a new kind of neural interface using microscale, flexible, bioelectronic fibers that seamlessly integrate with the body. Have you ever seen a fiber optic cable? Imagine a tiny strand that is as thin as a human hair. Each fiber integrates a range of functions, such as electrical, chemical, and optical capabilities to sense and modulate the biological environment. This gives us unprecedented access into the “symphony” of a properly functioning brain (something we'll talk about later that is ultra ultra cool…) and also a better understanding of the brain when it's not functioning properly. This is the kind of stuff the sci-fi future is made of, so buckle up! ➡️ https://neurobionics.io/ ➡️ https://rosspalmer.com/nicki-driscoll ➡️ Follow me on Instagram: @therosspalmer ➡️ Subscribe on YouTube: @therosspalmer

Imagine a world where healthcare is transformed by the power of sono-optogenetics, where wearable devices seamlessly interface with our brains, and where neurostimulation pioneers push the boundaries of what's possible. It's not science fiction; it's the extraordinary realm of neurotechnology, where innovation knows no bounds. Today, we're diving headfirst into this incredible world. But that's not all. We have a special guest who's here to share his insights and experiences about creating start-ups in healthcare and neurotech. Let us introduce our guest, Ilya Pyatnitskiy, MD, a visionary entrepreneur and neuroscientist.  In the past, he co-founded successful startups, led groundbreaking projects in breast cancer screening, and earned patents for his contributions to neuroscience. But that's not all. He's currently at the forefront of developing neurostimulation, focused on the creation and assessment of wearable brain-computer interfaces, including applications in in-home stroke rehabilitation. Join us in this episode as Ilya provides insights into healthcare start-up development. Learn about the ever-evolving landscape of healthcare and neurotechnology! About the Podcast Guest: Meet Ilya Pyatnitskiy (Eli Friday), MD Ilya Pyatnitskiy, also known as Eli Friday, MD, is a dynamic force in the world of neuroscience and medical innovation. With a background spanning radiology, entrepreneurship, and groundbreaking research, he's making waves in the field of neurostimulation and brain-computer interfaces. Here's a glimpse into his remarkable journey: Innovative Entrepreneur: Ilya was a co-founder of two pioneering startups in the European health tech sector. His entrepreneurial spirit led to a successful exit through Aqui-hire and IP Acquisition, leaving an indelible mark on the industry. Medical Visionary: Ilya's dedication to improving healthcare is evident in his role as the mastermind behind the first-of-its-kind breast cancer screening program in Moscow. His visionary leadership catapulted this program to success. Research Maven: In his research pursuits, Ilya's achievements are nothing short of remarkable. He conceived, developed, and patented novel MRI protocols and 3D visualization technologies for peripheral nerve imaging, pushing the boundaries of medical imaging. Awards & Accolades: His contributions to the field have earned him the esteemed Basic Science Awards from the Sexual Medicine Society of North America in both 2019 and 2020. Neurotech Trailblazer: Ilya's expertise in neurostimulation is unparalleled. His current focus lies in the development and evaluation of wearable brain-computer interfaces for commercial applications, with a particular emphasis on treating various diseases. Notably, he's pioneering a wearable system for in-home stroke rehabilitation. The Wang Lab Connection: Ilya is currently a research associate at UT Austin, working within the Wang Lab, a renowned biomedical research laboratory led by Dr. Huiliang (Evan) Wang. The lab's core research areas encompass nanomaterials, electronics, and genetic approaches in neural interfacing, bridging the realms of neuroscience research and clinical applications. For an in-depth exploration of Ilya's achievements and contributions, you can connect with him on LinkedIn: https://www.linkedin.com/in/ilya-pyatnitskiy-b0016667/ Explore more about Ilya's groundbreaking work and insights through his Google Scholar profile here: https://g.co/kgs/J1mDWz Discover the innovative research happening at the Wang Lab, UT Austin, by visiting their website: https://wanggroup.bme.utexas.edu   About the Podcast Host: The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a neuroscience educator, research consultant, and career coach for students and recent graduates in neuroscience and neurotechnologies. As a professional coach with a background in the field, Dr. K understands the unique challenges and opportunities facing students in this field and can provide personalized coaching and support to help you succeed. Here's what you'll get with one-on-one coaching sessions from Dr. K: Identification and pursuit of career goals Guidance on job search strategies, resume and cover letter development, and interview preparation Access to a network of professionals in the field of neuroscience and neurotechnologies Ongoing support and guidance to help you stay on track and achieve your goals You can always schedule a free neurocareer consultation/coaching session with Dr. K at https://neuroapproaches.as.me/free-neurocareer-consultation Subscribe to our Nerocareers Newsletter to stay on top of all our cool neurocareers news at updates https://www.neuroapproaches.org/neurocareers-news

We discuss the use of optogenetics in the treatment of retinal degenerations with Dr. Michael Singer, Adjunct Professor of Ophthalmology, University of Texas Health Science Center, San Antonio.

Hey BlurtstarsVictoria is reeling that the longest serving Labor premier has suddenly resigned. Well, maybe not all Victorians are crying. Speaking of crying, Hollywood screenwriters and actors might be crying with joy as their strike might be coming to an end.On tonight's show, in our Science segment we'll cover the latest NASA success story and have conversations with plants. And in Econobabble, Wencee will tell us all about a method to make housing affordable. It's not a quick fix, but it could work. And Kegsta will let us in on the economics state of the states.Tune in and find out on https://www.youtube.com/@thenewblurt7773, with Wencee and the Kegsta.Subscribe to our newsletter: https://thenewblurt.substack.com or contact us at blurtstar@gmail.com.BanterVictoria's longest serving Labor premier, Dan Andrews, resigns after 9 years as premier and 21 years in Victorian politics →Guardian News | Daniel Andrews resigns as premier of VictoriaScreenwriters strike. What's the latest news? Find out here →CNN News | Writers Guild and studios reach tentative deal, potentially ending a monthslong strike that ground Hollywood to a haltWhat happens when you take a selfie and forget about your surroundings? You fall 10m down a cliff →Guardian News | Woman falls off Phillip Island cliff while trying to take photosCan Apple Airpods survive in your stomach? One woman find out the hard way →Apple Insider News | Woman accidentally discovers swallowed AirPods are acid resistant for nine hoursScienceNASA's spacecraft that dug asteroid dust, arrives on Earth ready to be studied →NASA | OSIRIS-REx Sample Return Capsule Lands in the Utah DesertEver conversed with plants? Researchers at the University of Cambridge are using Optogenetics, light stimulus, to activate plant cells. You can find detail here →Science Daily | Conversations with plants: Can we provide plants with advance warning of impending dangers?EconobabbleEver wondered how your states' economy is performing against other states? We have the answers and here are some links you can read for more information →Commonwealth Bank | State of the States - State and Territory Economic Performance ReportGrant Thornton | 2023-2024 State Budget Updates: Navigating the evolving grant funding landscapeReserve Bank Australia | Economic Growth ExplainerIn Australia there's a housing crisis that has been decades in the making. New Zealand made changes seven years and are only now seeing positive changes that is making housing more affordable. Find out what the NZ government did here →ABC News | New Zealand's housing density experiment saw approvals for new builds in Auckland 'skyrocket' while house prices kept climbingFollow us on our socials:YouTube - https://www.youtube.com/@thenewblurt7773Facebook - https://www.facebook.com/blurtstar/Instagram - https://www.instagram.com/blurtstar/Twitter - @BlurtNew This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thenewblurt.substack.com

Transformational research techniques shaping our understanding of how the brain works.Guest Karl Deisseroth is a bioengineer and a psychiatrist who has developed two of the most transformational research techniques shaping our understanding of how the brain works — optogenetics, which allows neuroscientists to control brain cells with light, and CLARITY, a way to render the brain's gray matter transparent yet retain all its intricate wiring for easier study.  There is a vast chasm between neuroscience and psychiatry, Deisseroth says of the reasons he felt compelled to develop technology ahead of pursuing science. It was never a trade-off of one over the other, however. It was simply where we had to go to get better at the science, Deisseroth tells fellow bioengineer and host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Chapters:(00:00:00)  Introduction to Karl DeisserothRuss Altman introduces the episode and Karl Deisseroth, highlighting his roles as a professor of bioengineering and psychiatry. Explanation of Karl Deisseroth's approach to addressing challenges in neuroscience through technology development and application.(00:03:23) Balancing Technology Development and Scientific ExplorationDiscussion on the challenges of balancing technology development with scientific exploration. Karl Deisseroth's perspective on integrating technology development as a primary goal in neuroscience research.(00:05:03) Optogenetics: Controlling Neurons with LightIntroduction to optogenetics as a method for precise control of individual cells using light. Explanation of the historical challenges in controlling neurons and the need for precise techniques.(00:07:25) Importance of Bioengineering in InnovationHighlighting the role of bioengineering in translating scientific ideas into practical tools. Importance of collaboration and interdisciplinary approaches in bioengineering and neuroscience.(00:10:04) Discovering Microbial Rhodopsins and OpsinsKarl Deisseroth explains the class of proteins known as microbial rhodopsins and their genes, microbial opsins. Discussion on the historical knowledge of these proteins and their presence in biochemistry textbooks.(00:12:50) Realizing Optogenetics in Human BrainsKarl Deisseroth discusses the practical application of optogenetics in the central nervous system of human beings. An example of a successful experiment by Karl's colleague Botond Roska, enabling a blind person to see objects.(00:16:01) Bridging Psychiatry and NeurotechnologyTransition to discussing Karl Deisseroth's role as a practicing psychiatrist and the challenges faced in patient care. Integration of clinical experiences into scientific research and its impact on experimental design and understanding disease processes.(00:16:54) The Intersection of Science and MedicineExamination of the balance between clinical practice and scientific research in Karl Deisseroth's work. Importance of firsthand patient experiences in shaping research goals and addressing clinical challenges.(00:20:25) Unraveling Brain Complexity with OptogeneticsDiscussion on the complexity of the brain's parts list and challenges in categorizing cell types. Utilizing optogenetic tools to explore specific brain cell types and their functions. The intersection of clinical psychiatry, technology, and neuroscience in advancing our understanding of the brain.(00:21:00) Integrating Optogenetics into NeuroscienceExploration of the significance of having a detailed parts list for the brain and its impact on optogenetic research. Integrating optogenetic tools to study diverse brain functions and disorders. The evolving landscape of neuroscience research and the potential applications of optogenetics in the future.(00:24:53) The Interconnectedness of Brain CellsExamination of experiments recording from tens of thousands of cells while observing a thirsty mouse's behavior. Insights into the rapid and interconnected nature of the brain, lead to widespread correlations among neurons.(00:28:05) Writing "Projections": Balancing Science and LiteratureKarl Deisseroth's motivation for writing "Projections" was to share the inner worlds of psychiatric patients and communicate scientific advancements. Challenges in balancing literary creativity with scientific accuracy, capturing patients' experiences while staying grounded in truth.(00:31:02) Receiving Feedback and Impact of "Projections"Reflection on the reception of "Projections" and feedback received from readers, including patients with psychiatric disorders.Karl Deisseroth's satisfaction in capturing the experiences of patients and the impact of the book on diverse readers.

Save Souls with an OfGod Tshirt: https://sjwellfire.com/shop/ Join our newsletter: https://sjwellfire.com/ Gab: https://gab.com/sjwellfire Support us to save souls via the news: https://sjwellfire.com/support/ or scott@sjwellfire.com paypal Prepare: https://sjwellfire.com/partners/ Optogenetics is a revolutionary scientific technique that enables researchers to manipulate and control the activity of specific neurons in the brain using light (blue light that is emitted from your black mirror devices). This technology has transformed the field of neuroscience, allowing scientists to gain a deeper understanding of the brain's complex functions and paving the way for potential treatments for various neurological disorders. One of the key elements of optogenetics involves the use of blue light to control neuronal activity, opening up new possibilities for research and therapies. Optogenetics combines the principles of genetics and optics to achieve precise control over the activity of neurons. The technique relies on the use of light-sensitive proteins called opsins, which are introduced into the neurons of interest through genetic modification. Opsins act as molecular switches that respond to specific wavelengths of light by either activating or inhibiting neuronal firing. Blue Light and Opsins: Blue light is one of the most commonly used wavelengths in optogenetics due to its ability to efficiently activate opsins. The two primary types of opsins used in optogenetics are channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR). ChR2 is activated by blue light, while NpHR is activated by yellow light. In this write-up, we will focus on the use of blue light to control neuronal activity. Mind Control Activation: When blue light is shone on neurons expressing ChR2, the opsins open ion channels, allowing positively charged ions to flow into the cell. This influx of ions leads to a change in the neuron's membrane potential, causing it to depolarize and fire an action potential. This results in the activation of the targeted neurons, allowing researchers to precisely stimulate them. Inhibition: Conversely, blue light can be used to control neuronal inhibition through opsins like NpHR. When exposed to blue light, NpHR pumps negatively charged chloride ions into the neuron, hyperpolarizing the membrane potential. This hyperpolarization makes it more difficult for the neuron to generate action potentials, effectively silencing its activity. Applications of Blue Light Optogenetics: optogenetics has provided researchers with a powerful tool to investigate the functions of specific brain circuits and their roles in behavior, cognition, and disease. By selectively activating or inhibiting neurons in animal models, scientists have gained insights into conditions like depression, addiction, Parkinson's disease, and more. While optogenetics is primarily a research tool, its findings may hold promise for the development of future therapeutic interventions. By understanding the neural circuits involved in neurological disorders, researchers may identify new targets for treatments, potentially leading to more effective therapies. The use of optogenetics, including the use of blue light to control neuronal activity, raises ethical questions about the manipulation of the brain. Concerns include issues of consent, privacy, and potential misuse of the technology. Ethical guidelines and careful consideration are crucial as this field continues to advance. This is the mind controlism technology of the Fourth Beast System. Optogenetics and the use of blue light to control neuronal activity have revolutionized neuroscience research, offering unprecedented precision in studying the brain. While it has opened new avenues for understanding brain function and exploring potential therapies, it also poses ethical challenges that warrant ongoing discussion. As technology continues to evolve, optogenetics may play a vital role in unraveling the mysteries of the mind and advancing our understanding of neurological disorders.

Today on The Prather Point LIVE at 4 pm ET / 1 pm PT on RUMBLE:https://rumble.com/v3mqu1j-ebs-wednesday-optogenetics-not-5g.htmlCBRN = CHEM-BIO-RADIO-NUC!DR. LEE MERRITT EXPLAINS!TRUMP CHARGES COLLAPSE!SHASTA SUES GILEAD!Never get stuck in an emergency. Visit our sponsors:➡ Save $150 on 3 months of Emergency Food Visit http://PratherPrepSupply.com------------------------

Dr. Sharon Stills interviews Dr. Lee Merritt, a medical rebel with an impressive background in medicine and policy, about her extensive research on the pandemic, the lies that were told, her theories on what really happened, and her hope for the future. You wouldn't want to miss this informative interview!

This week, Jonathan is joined by Kevin Tracey, Feinstein Institutes for Medical Research, Manhasset, New York, USA, to explore bioelectronic medicine; its use in the treatment of inflammation, including rheumatoid arthritis; and its future. The pair further dives into the vagus nerve and the link between vagotomy and Parkinson's disease, and the use of monoclonal anti-TNF antibodies to treat septic shock.  Use the following timestamps to navigate the content in this episode: (00:00)-Introduction  (02.36)-Tracey's origin story and route into medicine   (04.46)-Defining bioelectronic medicine   (07.15)-Septic shock and monoclonal anti-TNF antibodies   (10:10)-The vagus nerve and 1493  (22:15)-Vagotomy and Parkinson's disease   (26:32)-Optogenetics  (29:52)-Replacing pharmaceuticals with bioelectronics   (32:59)-Saving lives with vagus nerve stimulation to treat inflammation  (35:01)-Cancer neuroscience   (36:52)-Tracey's three wishes for improving his field of specialty 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.26.546543v1?rss=1 Authors: Lukashkina, V. A., Levic, S., Simoes, P. M., Xu, Z., Li, Y., Haugen, T., Zuo, J., Lukashkin, A. N., Russell, I. J. Abstract: Cochlear outer hair cells (OHCs), acting as bidirectional cellular mechanoelectrical transducers, generate, receive, and exchange forces with other major elements of the cochlear partition, including inner hair cells (IHCs). Force exchange is mediated via a supporting cell scaffold, including Deiters (DC) and outer pillar cells (OPC), to enable the sensitivity and exquisite frequency selectivity of the mammalian cochlea. We conditionally expressed a hyperpolarizing halorhodopsin (HOP), a light-gated inward chloride ion pump in DCs and OPCs. We measured extracellular receptor potentials (ERPs) and their DC component (ERPDC) from the Cortilymph (CL) of HOP expressing mice and compared the responses with similar potentials from littermates without HOP expression. Compound action potentials (CAP) were measured as an indication of IHC activity. HOP laser activation suppressed cochlear amplification through changing timing of its feedback, altered basilar membrane (BM) responses to tones at all measured levels and frequencies, and reduced IHC excitation. Our HOP activation results here complement previous channelrhodopsin activation studies in exploiting optogenetics to measure and understand the roles of DCs and OPCs in vivo in controlling the mechanical and electrical responses of OHCs to sound and their contribution to timed and directed electromechanical feedback to the mammalian cochlea. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Brandon Berry, Ph.D. ( https://halo.dlmp.uw.edu/people/brandon-berry/ ) is a postdoctoral researcher in the Kaeberlein Laboratory at University of Washington where his research focuses on how aging and metabolism are linked. Dr. Berry is interested in how mitochondria, the powerhouses of cells, contribute to and modulate functional decline that occurs during aging, and he is involved in using novel tools, like optogenetics, to precisely control mitochondria and metabolism with light. Through these types of experiments, he can more precisely determine if mitochondrial dysfunction is a cause or a consequence of metabolic aging and may reveal new ways to understand and impact health. Dr. Berry has BS in Biochemistry from SUNY Geneseo, and an MS and PhD in Physiology from University of Rochester. Support the show

In this episode, our guest is Mustafa Khammash. Mustafa is the director of the Control Theory and Systems Biology Lab at ETH Zürich and guides us in this episode as we explore Cybergenetics - the cutting-edge intersection of control theory and synthetic biology. From biomolecular control to antithetic motifs, we discuss real-world applications and ethical dilemmas. Don't miss it!Outline00:00 - Intro00:50 - Cybergenetics02:22 - Genetics 10105:07- Where control meets biology06:49 - Mustafa's early steps in biology: why do dairy cows get milk fever?12:05 - Systems and synthetic biology14:34 - History of synthetic biology17:16 - On biological computing23:23 - On biomolecular control29:27 - The birth of the Antithetic motif for molecular feedback control39:25 - Enabling technologies48:28 - How the antithetic motif works57:20 - Model organisms 01:00:45 - Applications of Cybergenetics 01:06:45 - Ethical dilemmas in Cybergenetics01:10:57 - On the internal model principle01:16:01 - Advice to future students01:19:51 - OutroLinks - Mustafa's website: https://bsse.ethz.ch/ctsb- Paper on calcium regulation: https://tinyurl.com/4p9xu8j2- History of synthetic biology: https://tinyurl.com/2p8ej8fw- Motifs: https://tinyurl.com/3vcnjvj3- Paper - In silico feedback for in vivo regulation of a gene expression circuit: https://tinyurl.com/yw98d8k8- Paper - A universal biomolecular integral feedback controller for robust perfect adaptation: https://tinyurl.com/bddux4x3- Optogenetics: https://tinyurl.com/r6yw9s37- About the fluorescent protein: https://tinyurl.com/bdzm37fs- Electroporation: https://tinyurl.com/3hhjxanp- Paper - Cybergenetics: Theory and Applications of Genetic Control Systems: https://tinyurl.com/222f8924- Paper - Universal structural requirements for maximal robust perfect adaptation in biomolecular networks: https://tinyurl.com/3a2bm35fPodcast infoPodcast website: https://www.incontrolpodcast.com/Apple Podcasts: https://tinyurl.com/5n84j85jSpotify: https://tinyurl.com/4rwztj3cRSS: https://tinyurl.com/yc2fcv4yYoutube: https://tinyurl.com/bdbvhsj6Facebook: https://tinyurl.com/3z24yr43Twitter: https://twitter.com/IncontrolPInstagram: https://tinyurl.com/35cu4kr4Acknowledgments and sponsorsThis episode was supported by the National Centre of Competence in Research on «Dependable, ubiquitous automation» and the IFAC Activity fund. The podcast benefits from the help of an incredibly talented and passionate team. Special thanks to B. Seward, E. Cahard, F. Banis, F. Dörfler, J. Lygeros, as well as the ETH and mirrorlake studios. Music was composed by A New Element. Support the show

Drs. Akshay Thomas and Priya Vakharia join to discuss the March 2023 issue of Retinal Physician, found online at http://www.retinalphysician.com. Topics covered include gene therapy and immunogenecity, applications in dry AMD, and optogenetics.Relevant Financial Disclosures: Dr. Sridhar has consulted for RegenxBio and Apellis in the past 2 years.You can claim CME credits for prior episodes via the AAO website. Visit https://www.aao.org/browse-multimedia?filter=Audi

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.27.525963v1?rss=1 Authors: Johnsen, K. A., Cruzado, N. A., Willats, A. A., Rozell, C. J. Abstract: Recent advances in neurotechnology enable exciting new experiments, including novel paradigms such as closed-loop optogenetic control that achieve powerful causal interventions. At the same time, improved computational models are capable of reproducing behavior and neural activity with increasing fidelity. However, the complexities of these advances can make it difficult to reap the benefits of bridging model and experiment, such as in-silico experiment prototyping or direct comparison of model output to experimental data. We can bridge this gap more effectively by incorporating the simulation of the experimental interface into our models, but no existing tool integrates optogenetics, electrode recording, and flexible closed-loop processing with neural population simulations. To address this need, we have developed the Closed-Loop, Electrophysiology, and Optogenetics experiment simulation testbed (Cleo). Cleo is a Python package built on the Brian 2 simulator enabling injection of recording and stimulation devices as well as closed-loop control with realistic latency into a spiking neural network model. Here we describe the design, features, and use of Cleo, including validation of the individual system components. We further demonstrate its utility in three case studies using a variety of existing models and discuss potential applications for advancing causal neuroscience. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.17.512538v1?rss=1 Authors: Shiu, F. H., Skelton, H., Berglund, K., Fernandez, A. M., Gutekunst, C.-A. N., Robinson, E. R., Wang, Z., Gross, R. E. Abstract: Previous studies in human patients and rodent models of Parkinsons disease (PD) have established neuroprotection of dopaminergic (DA) neurons in substantia nigra pars compacta (SNC) by physical exercise, but the precise origin of this neuroprotective effect has yet to be elucidated. In this study, we tested a hypothesis that enhanced activity of DA neurons in SNC results in neuroprotection using the unilateral 6-hydroxydopamine (6-OHDA) injection model in mice. To increase activity of DA neurons chronically and specifically, we injected an adeno-associated viral vector carrying a step-function luminopsin (SFL) - a fusion protein of light-emitting Gaussia luciferase and light-sensing step-function channelrhodopsin 2 - into SNC ipsilateral to 6-OHDA using the pan-neuronal human synapsin I promoter or the Cre-lox system in transgenic mice expressing the recombinase under control of the tyrosine hydroxylase (TH) promoter. Upon application of SFL substrate, coelenterazine (CTZ), the luciferase moiety of luminopsin emits bioluminescence which in turn activate the opsin moiety. Daily injection of CTZ for 4 weeks ameliorated a stereotypical behavior, namely ipsiversive rotations, induced by unilateral 6-OHDA. In addition, postmortem immunohistochemistry against TH revealed less severe neurodegeneration of DA neurons compared to vehicle-injected control animals. Furthermore, when mice were pretreated with ANA-12, a selective antagonist for tropomyosin receptor kinase B (TrkB), the behavioral improvement and neuroprotective effect were diminished. These results suggest that increased neuronal activity of DA neurons provides neuroprotection against 6-OHDA injury and alleviates its symptoms through the brain-derived neurotrophic factor-TrkB pathway. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

It's June 15, 2021. This is the season finale of 'Cherry, Bird, Cow!' In this special episode, Winston meets his real moms, Delilah and Liv. The gang also teaches us about the prospect of 'infinite plastic,' a high school in Florida that censored yearbook photos of girls for reasons of modesty, how the CDC is advising to not kiss chickens and ducks, the power of Roblox music, and how scientists partially restored a man's eyesight by using optogenetics.

It's June 15, 2021. This is the season finale of 'Cherry, Bird, Cow!' In this special episode, Winston meets his real moms, Delilah and Liv. The gang also teaches us about the prospect of 'infinite plastic,' a high school in Florida that censored yearbook photos of girls for reasons of modesty, how the CDC is advising to not kiss chickens and ducks, the power of Roblox music, and how scientists partially restored a man's eyesight by using optogenetics.

Lauren Aguirre is an award-winning science journalist who has produced documentaries, short-form video series, podcasts, interactive games and blogs for the PBS series "Nova." She has covered everything from asteroids to human origins to art restoration, but is particularly fascinated by the brain. "The Memory Thief" is Lauren's first book. In this conversation, Lauren and KMO discuss: 02:03 – Lauren's memory incident 06:42 – Waking up and not knowing where you are 08:28 – Retrograde and anterograde amnesia 13:10 – The fentanyl connection 20:53 – Experimental brain surgery 24:18 – Amnesia sufferers' self-worth 29:13 – Faking anterograde amnesia 31:18 – Science communication 33:38 – Disappointment in science 34:53 – The Memory Thief's target audience 36:28 – Multilayer narratives 39:13 – Our shared experience of forgetting 43:08 – Remembering our remembering of events 44:38 – The trauma connection 47:35 – Optogenetics 49:08 – The scientific process and the pursuit of truth Lauren Aguirre (The Guest): laurenaguirre.com @lsaguirre KMO (The Host): Twitter: @Kayemmo en.padverb.com/kmo Padverb: The Padverb Telegram Channel: t.me/padverbpodcast

Nick talks to neuroscientist Dr. David Anderson, a professor at Caltech whose lab studies the neurobiological basis of animal behavior and emotion. They discuss: technologies for understanding cause-and-effect in the brain; neurobiological basis of animal behavior, including aggression/fighting, mating, feeding, and social behavior; how hormones such as estrogen regulate behavior; emotions, feelings, and consciousness; and David's new book, "The Nature of the Beast."Support M&M:Sign up for the weekly Mind & Matter newsletter[https://mindandmatter.substack.com/?sort=top]The Amino Co., shop science-back amino acids supplements. Use code ‘MIND' to save 30%.[aminoco.com/MIND]Follow Nick's work through Linktree:[https://linktr.ee/trikomes]Learn more about our podcast sponsor, Dosist[https://dosist.com] Support the show

In this episode, hosts Jeremy and Ingo chat with Dr. Valentina Emiliani. Dr. Emiliani's lab has pioneered the use of wave-front shaping for neuroscience. In particular, they demonstrated a number of new techniques based on computer-generated holography to gain 3D optogenetic control of neural populations.

Huberman Lab Podcast Notes The areas of the brain that control feeding, fleeing, fighting, and mating are in close proximity in the brain possibly to help the animal decide what behavior to prioritize and what to shut down at any given moment“Aggression refers more to a description of behavior than the internal state. Aggression could reflect fear, anger, hungry (in animals).” – Dr. David AndersonEstrogen and the aromatase of testosterone into estrogen is really what generates aggression, not testosterone aloneArousal is tethered to the mating and reproductive process: without a seesaw between sympathetic and parasympathetic, there is no matingThe same behavior can reflect different states and different states can converge on multiple behaviorsIn social animals and humans, the body secretes higher levels of tachykinin when we are not socially connected enough – symptoms: increased irritability, paranoia, fear, lonelinessEmotion involves bidirectional communication between the brain and body, mediated by the peripheral nervous system, autonomic nervous system, and Vagus nerveRead the full notes @ podcastnotes.orgMy guest is David Anderson, PhD, a world expert in the science of sexual behavior, violent aggression, fear and other motivated states. Dr. Anderson is a Professor of Biology at the California Institute of Technology (Caltech), a member of the National Academy of Sciences and an investigator with the Howard Hughes Medical Institute (HHMI). We discuss how states of mind (and body) arise and persist and how they probably better explain human behavior than emotions per se. We also discuss the many kinds of arousal that create varying levels of pressure for certain behaviors to emerge. We discuss different types of violent aggression and how they are impacted by biological sex, gender, context, prior experience, and hormones, and the neural interconnectedness of fear, aggression and sexual behavior. We also discuss peptides and their role in social isolation-induced anxiety and aggression. Dr. Anderson also describes novel, potentially powerful therapeutics for mental health. This episode should interest anyone wanting to learn more about mental health, human emotions, sexual and/or violent behavior.   Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Levels: https://levels.link/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Dr. David Anderson Dr. David Anderson The Nature of the Beast Dr. David Anderson's Lab Dr. Anderson's publications Articles Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits Resources Mouse switching from mating behavior to aggressive behaviors upon stimulation of VMH VMH stimulation causes mouse to display aggressive behaviors toward an inanimate object (e.g., glove) Picture of Periaqueductal Gray (PAG) Timestamps (00:00:00) Dr. David Anderson, Emotions & Aggression  (00:03:33) Momentous Supplements  (00:04:27) Levels, Helix Sleep, LMNT  (00:08:10) Emotions vs. States (00:10:36) Dimensions of States: Persistence, Intensity & Generalization (00:14:38) Arousal & Valence  (00:18:11) Aggression, Optogenetics & Stimulating Aggression in Mice, VMH (00:24:42) Aggression Types: Offensive, Defensive & Predatory  (00:29:20) Evolution & Development of Defensive vs. Offensive Behaviors, Fear (00:35:38) Hydraulic Pressures for States & Homeostasis (00:38:33) AG1 (Athletic Greens) (00:39:46) Hydraulic Pressure & Aggression (00:44:50) Balancing Fear & Aggression (00:48:31) Aggression & Hormones: Estrogen, Progesterone & Testosterone (00:52:33) Female Aggression, Motherhood (00:59:48) Mating & Aggressive Behaviors  (01:05:10) Neurobiology of Sexual Fetishes  (01:10:06) Temperature, Mating Behavior & Aggression (01:15:25) Mounting: Sexual Behavior or Dominance? (01:20:59) Females & Male-Type Mounting Behavior (01:24:40) PAG (Periaqueductal Gray) Brain Region: Pain Modulation & Fear  (01:30:38) Tachykinins & Social Isolation: Anxiety, Fear & Aggression  (01:43:49) Brain, Body & Emotions; Somatic Marker Hypothesis & Vagus Nerve  (01:52:52) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, AG1 (Athletic Greens), Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

My guest is David Anderson, PhD, a world expert in the science of sexual behavior, violent aggression, fear and other motivated states. Dr. Anderson is a Professor of Biology at the California Institute of Technology (Caltech), a member of the National Academy of Sciences and an investigator with the Howard Hughes Medical Institute (HHMI). We discuss how states of mind (and body) arise and persist and how they probably better explain human behavior than emotions per se. We also discuss the many kinds of arousal that create varying levels of pressure for certain behaviors to emerge. We discuss different types of violent aggression and how they are impacted by biological sex, gender, context, prior experience, and hormones, and the neural interconnectedness of fear, aggression and sexual behavior. We also discuss peptides and their role in social isolation-induced anxiety and aggression. Dr. Anderson also describes novel, potentially powerful therapeutics for mental health. This episode should interest anyone wanting to learn more about mental health, human emotions, sexual and/or violent behavior.   Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Levels: https://levels.link/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Dr. David Anderson Dr. David Anderson The Nature of the Beast Dr. David Anderson's Lab Dr. Anderson's publications Articles Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits Resources Mouse switching from mating behavior to aggressive behaviors upon stimulation of VMH VMH stimulation causes mouse to display aggressive behaviors toward an inanimate object (e.g., glove) Picture of Periaqueductal Gray (PAG) Timestamps (00:00:00) Dr. David Anderson, Emotions & Aggression  (00:03:33) Momentous Supplements  (00:04:27) Levels, Helix Sleep, LMNT  (00:08:10) Emotions vs. States (00:10:36) Dimensions of States: Persistence, Intensity & Generalization (00:14:38) Arousal & Valence  (00:18:11) Aggression, Optogenetics & Stimulating Aggression in Mice, VMH (00:24:42) Aggression Types: Offensive, Defensive & Predatory  (00:29:20) Evolution & Development of Defensive vs. Offensive Behaviors, Fear (00:35:38) Hydraulic Pressures for States & Homeostasis (00:38:33) AG1 (Athletic Greens) (00:39:46) Hydraulic Pressure & Aggression (00:44:50) Balancing Fear & Aggression (00:48:31) Aggression & Hormones: Estrogen, Progesterone & Testosterone (00:52:33) Female Aggression, Motherhood (00:59:48) Mating & Aggressive Behaviors  (01:05:10) Neurobiology of Sexual Fetishes  (01:10:06) Temperature, Mating Behavior & Aggression (01:15:25) Mounting: Sexual Behavior or Dominance? (01:20:59) Females & Male-Type Mounting Behavior (01:24:40) PAG (Periaqueductal Gray) Brain Region: Pain Modulation & Fear  (01:30:38) Tachykinins & Social Isolation: Anxiety, Fear & Aggression  (01:43:49) Brain, Body & Emotions; Somatic Marker Hypothesis & Vagus Nerve  (01:52:52) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, AG1 (Athletic Greens), Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

Signs that some vapes inflame the brain and other organs, how a whiff of CO2 puts mosquitoes into feeding mode, how long, at present rates, it will take before science reaches gender parity, and how babies get their vitamin D. Chris Smith looks inside some of the latest papers in eLife... Get the references and the transcripts for this programme from the Naked Scientists website

We discussed and learned with Samarendra Mohanty, PhD: President and Founder of Nanoscope Technologies, about the fascinating science of vision restoration through making bipolar cells light-sensitive and the development program of the intravitreally administered gene therapy vMCO-010c, currently being investigated in a Ph2b trial of patients with retinitis pigmentosa.

Fifteen years ago, scientists discovered optogenetics, a technique of using light to stimulate light-sensitive receptors in order to turn brain cells “on” and “off" at the flip of a switch. Advances in optogenetics have allowed this technology to move from the laboratory to humans, and more recently biopharma companies have been quick to incorporate optogenetic therapies into their ophthalmology portfolios.In this episode of Back Bay's Life Science Report, Peter Bak is joined by Kevin Norman to discuss the promise and commercial considerations of optogenetics.Topics include: The basic principles of optogenetics and the diseases it may be a treatment for How Big Pharma, biotech and VC view the promise of optogenetics for the future Current issues, technical challenges and functional endpoints for active therapy trials like those with Nanoscope Therapeutics, GenSight Biologics, Allergan, etc. The state of play for how optogenetics may be useful as a technology beyond the realm of ophthalmology, including cancer Read Back Bay Life Science Advisors' latest industry article on optogenetics in Cell & Gene here.Make sure to subscribe to The Life Science Report podcast and follow Back Bay Life Science Advisors on LinkedIn and Twitter. Thank you for joining us.If there's a question or subject you'd like us to cover, submit it here. It may be the topic of one of our upcoming podcasts.

This podcast is about big ideas on how technology is making life better for people with vision loss. The Enigma machines that Germany used to encode messages during World War II were notorious for their complexity. Two Enigma experts — Dr. Tom Perera, a retired neuroscientist, and founder of EnigmaMuseum.com, and Dr. Mark Baldwin, an expert on the story of Enigma machines — tell us how the Allies were able to crack the code, by using input-output mapping. The human brain is similarly complex. Until recently, no one knew the code the retina used to communicate with the brain to create sight. Our guest, Dr. Sheila Nirenberg, a neuroscientist at Weill Cornell, and Principal and Founder of Bionic Sight has — using input-output mapping — cracked the retina's neural code, enabling her to recreate the electric signals to the brain that could restore sight in people with retinal degeneration. She has created a set of goggles that convert a camera's images into the code, via pulses of light. And she relies on optogenetics, a relatively new procedure in neuroscience that helps neurons become responsive to light. In her clinical trial, Dr. Nirenberg injects the optogenetic vector into the eye, and trial participants who are completely blind, like Barry Honig, who we speak with on this program, report being able to see light. In early studies, coupling the effects of the optogenetics with the code-enabled goggles has an even more impressive effect on patients' vision. Dr. Nirenberg is also using her knowledge of the visual neural code to inform machine learning applications that could also be further used to support people who are blind or visually impaired. Clinical trial participants are important partners in the journey of discovery, Dr. Nirenberg says. Barry Honig agrees. He was happy to participate to help ease the burden on future children diagnosed with eye diseases that would otherwise result in blindness, but thanks to these advancements, someday may not.   The Big Takeaways: Dr. Tom Perera and Dr. Mark Baldwin describe the history and workings of the Enigma machine, the complex encoding device that allowed Germany to take the upper hand at the beginning of World War II, a war in which communication was sent wirelessly, elevating the need for encryption. They then describe the Polish and British efforts to break Enigma, including standard decryption and Alan Turing's Bombe machine. Similar to the Enigma, the human brain is incredibly complex, and much of the codes that make it run have not yet been deciphered, until now. Our guest, Dr. Sheila Nirenberg, conducted extensive input-output mapping on live human retinas. She was able to keep them alive in a dish outside the body for a few hours, during which time she'd show them videos. As the retina perceived the films, Dr. Nirenberg mapped the electrical current that would pulse through the ganglion nerve. In this way, she was able to learn how the human eye sees and to decipher the code that allows our brains to perceive images. This code has been honed via evolution over millennia. Having cracked the retinal neural code, Dr. Nirengberg held the key to restoring vision in people who are blind from retinal degeneration. She developed goggles embedded with a camera to convert the visual world into the retina's neural code using pulses of light, but she still had to get these pulses of light into an unseeing eye. Optogenetics is the key to creating light perception. Optogenetics is a relatively new procedure in neuroscience, by which researchers have created a genetically modified virus based on light-responsive algae, which when injected into live human cells, recombines its DNA with the DNA of host cells. In Dr. Nirenberg's case, she injects the optogenetic vector into the patient's retina. Most patients report the restoration of light perception to varying degrees, with just the optogenetics alone. Coupled with the goggles, and with Dr. Nirenberg's visual neural code, this system could restore some vision in people who are blind. The trial is still in its early stages. Dr. Nirenberg also uses the retinal neural code to improve how computers see. Computer vision experts are teaching computers to “see” more like humans. Still, if they can equip algorithms with humanity's neural code, the goal of human-like vision becomes more easily achievable. Barry Honig is a participant in the clinical trial. After his optogenetic injection, he was able to perceive the menorah at Hanukkah. From different perspectives, Barry and Dr. Nirenberg agree on the importance of trial participants.   Tweetables: “The analogy between the Enigma and the human brain is rather interesting. The brain has … 10 billion brain cells, … the Enigma machine has 10 to the 114th power possible internal connections. And that is actually a lot more.” — Tom Perera, neuroscientist and founder of EnigmaMuseum.com “Millions of years of evolution honed the retina into pulling out … the right features. And then it converts those features into electrical pulses and sends them up to the brain. That's what a normal retina does.” — Dr. Sheila Nirenberg, neuroscientist at Weill Cornell, and Principal and Founder of Bionic Sight. “And so … you're watching the retina watch a movie. And … you're seeing what it would be sending … to your brain.” — Dr. Sheila Nirenberg, neuroscientist at Weill Cornell, and Principal and Founder of Bionic Sight.“So I went from … sort of bare light perception to … this recent past Hanukkah, I … said to my … wife, the menorah — I think it was the eighth day and … the whole menorah was lit!” — Barry Honig, clinical trial participant and founder of Honig International “Whether or not that's perfect, you know, time will tell, but … to be able to spare kids that, and equally as importantly, to spare their parents that, you know, if I could … just take an injection and be a part of it, then, … that's a lot of reward. — Barry Honig, clinical trial participant and founder of Honig International   Contact Us: Contact us at podcasts@lighthouseguild.org with your innovative new technology ideas for people with vision loss.   Pertinent Links: Lighthouse Guild Dr. Sheila Nirenberg Dr. Tom Perera Dr. Mark Baldwin Barry Honig

Dr.Feng Zhang, the award-winning biochemist best known for his central role in developing optogenetics and CRISPR technology, joins ARK analyst Ali Urman on this week's episode. Listeners will learn about the role of optogenetics in dissecting circuitries in the brain and Feng's experience of CRISPR. Feng shares some of the biggest hurdles optogenetics has to overcome and tells us where RNA editing could be even more effective than DNA editing. He gives us his predictions on the cost of this kind of technology and medicine, and how it is developing to cover even more genes. We touch on the repertoire of different enzymes, explore diagnostics, and talk about the role of prime editing. You will hear why Feng considers the present to be a golden age for biological research, come to understand his long-term vision for CRISPR's impact on the world, and much more! “There's an ever-expanding repertoire of enzymes that could be harnessed and developed for genome editing. I think, what we're seeing now is probably still the tip of the iceberg.” — @zhangf Key Points From This Episode: Feng's definition of optogenetics: a way to be able to dissect circuitries in the brain. What CRISPR is and what Feng's experience of it has been. One of the biggest hurdles of optogenetics: targeting different circuitries in the brain. How RNA could be even better than DNA editing. The expanding toolbox of different proteins that are allowing us to cover more genes. How the repertoire of different enzymes could be harnessed and developed for genome editing. Feng's thoughts on how quickly the cost will decline. CRISPR's relationship with diagnostics in terms of specificity and sensitivity. How prime editing could be used to change the number of variants. How using RNA for base editing could change the capabilities. One of the biggest roadblocks to genetic medicine: getting it into the right tissue. The challenge posed by regulatory framework. How the new methodologies being developed can improve off-target sensitivity. Why Feng considers the present to be a golden age for biological research. How Feng sees CRISPR affecting the world in the long term. Why he is excited about the future of programmable medicine.

The brain is the most complex organ, well... according to our brain. What if I told you, it is possible to EXPAND the brain the same way diapers expand?? We can also fire specific neurons in the brain to find harmful proteins responsible for Alzheimer's and blindness using a new technology... Ari discusses these insane possibilities with Edward Boyden, the pioneer of Expansion spectroscopy and Optogenetics, and a crucial asset of the neural engineering group at MIT!! Chit-Chatting and Questioning the World (chitchatworld.org)

In this episode, it will discuss: The active side of genetics belongs to the field of Optogenetics. You can turn off Diabetes, Alopecia, Autoimmune disease by changing your daily lifestyle. Diet and lifestyle essentially have to be on point. Know that genetics plays a very small portion of your life quality. Put aside genetics, take control of your health, and move forward. Related links: Learn More About Hair N Heal Program Johanna Dahlman on Healing Alopecia Naturally Why does Alopecia Persist? Why has it been months, years, and more struggling with hair loss? 2022 — State of Your Health and Hair Update The Million Dollar Question with Alopecia and How You Can Solve It Today! Learn How You Can Heal and Reverse Alopecia Connect with us: Instagram Youtube Channel Facebook

Modulating Bladder Function with Light: The Application of Optogenetics to the Urinary System

Karl Deisseroth and Viviana Gradinaru speak with senior editor Markus Elsner about the current state of optogenetics and how it can be used to better understand and treat human disease. See acast.com/privacy for privacy and opt-out information.

Paul is back this week and takes the lead by describing two papers he came across which both utilize optogenetics and a technique our hosts haven't yet discussed — calcium imaging. Balancing a conversation between science and general sensory perception, Jeff and Paul break down a couple experiments which use light to activate genetically modified cells in specific regions of a brain in order to alter an animal's perception of its surrounding environment.

This week Jeff introduces us to three prerequisite concepts that will help make understanding biology and neuroscience at a deeper level much easier. Transcription, translation, and transgenic animal models are discussed before being connected to the idea of optogenetics: genetically modifying parts of the brain to react to light. This is part one of a two-part episode duo.

What is learning and memory? Is amnesia really a loss of stored memories or something more? In this interview, we will discuss where memory goes and if there is a way to retrieve them after trauma. Recent studies have shown that spatial memories are encoded as sparse populations of cells that are activated during learning and are necessary for the retrieval of specific memories. We refer to these cells as "memory engram cells" and the focus of Tomás J Ryan and his team is to understand how engram cells are able to store specific memories as information. Here is a quick summary/breakdown of the video above. The old storage theory of amnesia is WRONG. The problem is the ability to retrieve the memory. Short term memory lasts a few hours. It is very disruptable (long term is not). Long term memory lasts your entire lifetime. It requires transcription and translation of many different genes. We have many different genes that regulate memory. They are different for short term and long term - playing roles at different stages. Most popular was CREB (turns on other genes). Engrams cells are structures in the brain where memories are stored. R They used optigenetics to prove engram cells were important for memory. Engram cells only account for 4-6% of the brain cells in the hippocampus (of mice). V Consolidation idea - a short term memory (unstable) forms into a long term memory (stable), thus stabilizing the engram. Optogenetics - let's us express photoactivatable opsins in whatever region of the brain we want. The brain is electrically active. They put certain opsins into brain cells and then stimulate them with light. These opsins can conduct ions - putting positively charged cations from the external environment of the cell into the neuron. This depolarizes the cell, which results in an action potential (creating neuronal activity). What they did at MIT was integrate optogenetics and memory engram cells. They tested parts of the brain using a transgenetics - they took immediate/early genes (genes that show activity as a function of neuronal spike) and used opsins to only activate those genes. Amnesia and Memory Learning is the enhancement of synaptic connections. Memory is a stable thing in the brain and can last for your entire life. Learning and recall are not "things", they are activities. Learning = process of making a memory. Recall = process of retrieving a memory. So the problem is not memory itself. Amnesic engram cells have a loss of synaptic strength. Increasing the synaptic strength helps get the memory (which is commonly seen in Alzheimer's (AD), Huntington's (HD)). If you increase the synaptic potentiation (increasing the dendritic spine density), esp. of the amnesic engram cells, you can get natural access to those memories. Neurotrophic factors (BDNF, NGF, CNTF, GDNF) do this, but are not localized nor memory specific. Learning something new (about something you are amnesic about) will train your brain to those particular engram cells. Once you activate the engram cells (with optogenetics), you can restore access to old information and add new information on those amnesic memories. Without dealing with the cause, you probably won't be able to really restore memories (in diseases like AD, HD, etc.) In late stages of neurodegeneration, you may actually lose memories. Actions to take for prevention Stay mentally active Engage in physical exercise Actions to take for amnesia (acute memory loss) Do everything to remind yourself of those experiences Retrain on the "forgotten" pieces We briefly discussed gene expression and histone acetylation to enhance memory. https://mybiohack.com/blog/tomas-j-ryan-debunking-amnesia-and-stabilizing-engram-cells

Optogenetics - how scientists are using light to control the brain.

Scientists have discovered that memories in mice can be recovered, at least temporarily, through optogenetics and light stimulus.  While there are some exciting therapies that may come from this, the flip side is that it may also allow for memories to be implanted and triggered. Also: Artificial intelligence research much farther along than expected; the Internet of Things wants to network your lawn and garden; and Uber shooter claims the app possessed him--like "an artificial intelligence" tapped into his body.