Podcasts about Dosing

Melatonin is often marketed as a simple sleep aid—but that's just the tip of the iceberg. In this episode of Integrative You Radio, Dr. Nick and Dr. Nicole break down the lesser-known but powerful role melatonin plays in detoxifying the brain and supporting neurological health. They explore how chronic stress, poor sleep habits, and lifestyle choices interfere with melatonin production—and how, when properly supported under physician guidance, melatonin can become a key ally in brain detox, gut-brain balance, and regenerative health. Whether you're battling insomnia, burnout, or brain fog, this episode offers eye-opening insights into a natural tool you may be overlooking.

The globalist-captured RDA recommends a milligram or less of iodine a day. The correct dose is 25 to several hundred milligrams daily.Support the show

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Show notes at pharmacyjoe.com/episode1054. In this episode, I'll discuss the optimal dosing regimen for meropenem and piperacillin/tazobactam in critically ill patients receiving continuous renal replacement therapy. The post 1054: What is the optimal meropenem and piperacillin/tazobactam dosing regimen for critically ill patients receiving continuous renal replacement therapy? appeared first on Pharmacy Joe.

Malignant Hematology Updates: Venetoclax dosing strategies continue to evolve HMA/Ven + IDH1/2 inhibitors: https://doi.org/10.1200/JCO-25-00640 HMA/Ven + revumenib: https://doi.org/10.1200/JCO-25-00914 Venetoclax + CPX-351: https://doi.org/10.1002/ajh.27723 APOLLO: https://doi.org/10.1200/JCO-25-00535 Iland APOLLO editorial: https://doi.org/10.1200/JCO-25-01496 ctDNA assessment vs. PET in Large B-Cell Lymphoma: https://doi.org/10.1200/JCO-25-01534

What was something on your childhood wishlist that you're still kind of mad that you never got?Calculating potency isn't just math—it's the fundamental skill that transforms your cannabis kitchen from a guessing game into a precise culinary art. Whether you've ever found yourself unexpectedly bonding with your couch for six hours after a miscalculated brownie or thrown away gifted edibles because you had no idea how strong they were, this episode solves the dosing dilemma once and for all.I break down the seemingly complex world of THC calculations into a straightforward formula anyone can master, walking you through real examples that demonstrate exactly how to determine what's in each serving of your homemade treats. You'll discover why even experienced cannabis consumers sometimes need just a fraction of a gram to create perfectly dosed edibles, potentially saving you significant money while delivering consistently reliable experiences. Grab your Edible Dosing Cheat Sheet over at the website. By the end, you'll understand why knowing your numbers isn't about taking the fun out of edibles—it's about ensuring every experience is the right kind of fun.Continue the conversation and start connecting—head to JoinBiteMe.com right now. You'll find a private community of cannabis growers, makers and lovers who are just as obsessed or curious as you are.Support the show Visit the website for full show notes, free dosing calculator, recipes and more.

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn **American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support!

Host Hiwa Alaghebandian is back with potentially the giggliest episode yet. It's the August Hot or Not, and the trends we're getting into this month are Black Seed Oil, MACRO-dosing Creatine, and the Artists Way.If you've been seeing these three trends popping off all over social media and wondering if they're worth checking out, tune in to hear about the science & Hiwa's personal experiences.As always, if you enjoy this episode, please make sure you are subscribed to the show to hear more, leave a 5-star review telling us what you liked about it, and please share with your community who you think would benefit from the episode.If you have any questions you want answered on the podcast, submit them to theblushpod@gmail.com or LEAVE A VOICEMAIL. You can also submit anonymously here.Follow The Show:follow Hiwa on Instagramfollow Hiwa on TikTok

In this episode of Dog Cancer Answers, Dr. Robert Silver shares advanced insights on how medicinal mushrooms can support dogs with cancer. From beta glucan dosing to choosing the right mushrooms, Dr. Silver offers practical tips for pet parents. Learn about mushrooms like turkey tail, reishi, and maitake, their effects on cancer and immunity, and how to safely introduce them to your dog's regimen. Key highlights include: • Beta glucan dosages for mild, moderate, and severe conditions. • The importance of using standardized mushroom extracts. • How medicinal mushrooms train the immune system over time. • Safety tips, potential side effects, and starting doses. Your Voice Matters! If you have a question for our team, or if you want to share your own hopeful dog cancer story, we want to hear from you! Go to https://www.dogcancer.com/ask to submit your question or story, or call our Listener Line at +1 808-868-3200 to leave a question. Related Videos: https://www.youtube.com/watch?v=iAgObIOhEMg https://www.youtube.com/watch?v=y-eGlk1KhUg Related Links: Our article on Medicinal Mushrooms: https://www.dogcancer.com/articles/supplements/medicinal-mushrooms-for-dogs/ Real Mushrooms: https://www.realmushrooms.com/ Chapters: 00:00 – Introduction 00:15 – Why Mushrooms Are a Lifestyle Supplement 00:30 – Beta Glucans: The Key to Mushroom Dosing 02:00 – Dosage Tiers: Wellness, Moderate, and Severe Conditions 03:30 – Safe Dosing: Start Low, Go Slow 06:00 – The Science of Beta Glucans and Immune System Activation 10:00 – Mushrooms as Long-Term Immune Trainers 12:00 – Short-Term vs. Long-Term Effects of Medicinal Mushrooms 13:15 – Multi-Mushroom Formulas: The Benefits of Blends 16:00 – Spotlight on Chaga and Its Unique Properties 18:30 – Recent Turkey Tail Study: What the Research Says 24:00 – Real Mushrooms and Standardized Extracts 26:00 – Final Tips on Dosing and Safety 27:00 – Closing Thoughts and Dr. Silver's Insights Get to know Dr. Robert Silver: https://www.dogcancer.com/people/robert-silver-dvm/ For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Steroid Synergy, Rate My Physique, TRT Dosing Frequency, Performance Cycle - BSG Coaching QA Skip Hill, Andrew Berry, Scott McNally 0:00 teaser 0:45 Intro and advertisers 1:45 Synergistic Stacks 6:00 Uncommon Synergistic Stacks 13:00 SLU-PP-332 Variability In Results and Dosing 17:15 Rate My Physique 1 24:00 Rate My Physique 2 30:00 Wanting to increase free test 48:00 Test Cyp or Test E dosing frequency for TRT 52:45 Performance Cycle For Older Guy 1:01:10 Skip's favorite meal post contest?

​ @NickWalker39 Gets Real About Training, Coming Back, GLP Meds + Why He Loves Disney Movies

Today's episode is going to be a bit of a deep dive into something that comes up so often in coaching conversations, in my DMs, and honestly in my own personal T1D journey—and that is: all the sneaky little things that might be sabotaging your Time in Range…without you even realizing it. If you've been working really hard on your diabetes management but your CGM is still looking like a rollercoaster…or you just feel stuck and frustrated…this one's for you. So grab your coffee, your CGM graph, your notebook, whatever you need, and let's rise. Quick Takeaways:Understanding insulin: Dosing beyond carbs, adjusting ratios, and the importance of timing How to take ownership of your T1D and get off the BG roller coaster The unexpected and most influential factors sabotaging your TIR: Mindset, sleep + recognizing your patters Timestamps:[02:02] Understanding insulin dosing beyond carbs [05:06] Importance of adjusting your rates + ratios  [07:05] Micro decisions and their ripple effects[12:50] “All roads lead back to mindset”[13:13] Taking ownership of your T1D management [15:13] Insulin timing (a game changer) [18:33] Addressing insulin resistance [20:46] How sleep impacts blood sugar stability [21:36] Recognizing your patterns What to do now: Follow me @lauren_bongiorno and @riselyhealth on Instagram to stay in the loop when new episodes drop.Our signature Decide and Conquer Group Coaching Program is officially expanding to include 12 months of support for the first time ever! That's 3 months of transformation + 9 months of continued coaching, growth, and community. Doors for the September round are open now, and early bird pricing runs through July 31st.

Drs. David Andes and Isabel Spriet join Dr. Jeannette Bouchard to discuss all of the top questions our audience had on fluconazole dosing. Who needs a load? How much fluconazole is too much fluconazole? And what did one of our experts do when they were asked about dosing fluconazole in a dolphin? Listen in to find out! Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Fluconazole PK Variability in Critically Ill: DOI 10.3390/microorganisms9102068 DALI Antifungal Follow-up: DOI 10.1186/s13054-015-0758-3

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Donanemab's New Dosing Regimen: Lowering ARIA Risk in Alzheimer's Care" John Sims, MD, head of medical development for donanemab at Eli Lilly and Company, joins NeurologyLive to discuss the recently updated label for donanemab (Kisulna), an anti-amyloid Alzheimer disease (AD) therapy. Sims breaks down the key safety data from the TRAILBLAZER-ALZ-6 study (NCT05738486) that led to a newly approved titration-based dosing regimen aimed at minimizing ARIA risk. He outlines considerations for clinicians treating patients with early-stage AD, including genotype-based stratification, ARIA severity patterns, and implications for prescribing and patient counseling. Furthermore, Sims also shares takeaways about donanemab's clinical impact and how the results may shape the future of anti-amyloid therapy development and AD care. Looking for more dementia and Alzheimer disease discussion? Check out the NeurologyLive® Dementia and Alzheimer disease clinical focus page. Episode Breakdown: 1:00 – Overview of the new donanemab dosing regimen and its goal to reduce ARIA risk 2:30 – Rationale behind the four different dosing strategies tested in Trailblazer-ALZ-6 6:00 – What clinicians should know about patient risk and genotype testing 8:00 – Neurology News Minute 10:10 – Clinical implications of the updated label, including risk-benefit conversations 13:45 – Surprising results from the trial, particularly for APOE4 homozygous patients The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Orexin-Targeting Agent TAK-861 Meets All End Points in Phase 3 FirstLight and RadiantLight Studies FDA Shuts Down Sarepta's Distribution of Gene Therapy Elevidys Following Patient Deaths AD109 Meets End Points in Phase 3 LunAIRo Trial, Eyeing FDA Submission for Obstructive Sleep Apnea Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Hey all you gardeners! Welcome back to the show, we're here to share some of the best growing tips, practices, genetics information and just about everything needed to get your garden delivering its best buds.  Before the guys kick off their discussion, they get normal - Earl is puffin on some OGKush, WM is toking on Blue Zushi and @Terp_Fi3nd is seshing on his Mecha-Godzilla. From there they get right to business talking about effective ways to grow your plants while cutting your costs.  They talk about where the money needs to be spent and where you can save and adjust your spending, to create a set-up that is perfect for your desired results and the level of growing you plan to take on. Mr Weedman got a special delivery - a THC infused mocktail from Mrs Weedman midway through the show...stick around to see him totally zooted.  Dosing, you know - it's a thing, and she got it ALL wrong! Haha. Thanks for listening and as always, hit us up...IG: @terp_fi3nd  ---IG: @earl217 and @iamtheregalbeagleEmail: ThatRegalBegal@gmail.com---Twitter: @weedman420podYouTube: Weedman420 ChroniclesEmail: weedman420chronicles@gmail.com---Swag & Shop: https://eightdecades.comIG: @eightdecadesEmail: eightdecadesinfo@gmail.com---#High #Cannabis #StomptheStigma #FreethePlant #CannabisEducation  #CannabisResearch #Weed #Marijuana #LegalizeIt #CannabisNews #CBD #Terpenes  #CannabisPodcast #Podcast #eightdecades #Homegrow #Cultivation #BigEarl #Weedman420Chronicles #GrowHour #seeds #genetics #nutrients #IPM #Burpinthebag #LED #Lights #Atmosphere #TheRegalBegalBeanCo #Autoflower #autos #regs #photos #feminized #terps #plantmedicine #holistichealing #holistic  #seedbreeder #seedbank #beans #forage #chemisty #science #plants #hash #collab #flushCOPYRIGHT 2021 Weedman420Chronicles© Suggestions? Questions? Chat with us here.Support the show

The Peptique is LIVE! Go to https://thepeptique.com/ to get all your research peptides .As a loyal listener use the discount code VIP10 to get 10% off our entire line of products.Have questions? Feel free to reach out to me: tarawest@westwellnessatx.comWant to get started the right way, but don't know where to start. Email me tarawest@westwellnessatx.com to set up a 30 minute $100 session to get your personalized protocol. A special discount on your first order will be included. These spots fill up fast so schedule today!Follow me on instagram @westwellnessatx, @thepeptiqueIn this episode, I'm breaking down some of the biggest mistakes people make when getting started with peptides. Honestly, it can feel like the wild west out there—so much info, so many opinions, and not a lot of clarity. I've been in this space for a while now, and I've definitely learned a lot through trial and error. That's why I always tell people: do your research before jumping into any peptide protocol.One of the most important things I've found is that you have to know your goal before choosing a peptide. Are you trying to lose fat? Sleep better? Boost your focus? Having a clear goal makes it so much easier to pick the right peptide and get results that actually match what you're aiming for.I also talk about stacking—what works, what doesn't, and why randomly combining peptides without understanding how they work can totally backfire. I've seen it happen. Dosing is another big one. More isn't always better, and starting too high or too low can lead to disappointment—or side effects.At the end of the day, peptides are powerful tools, but they're not magic. They work best when you've already got your basics dialed in—nutrition, sleep, stress, recovery. This episode is all about helping you lay that foundation so you can actually get the most out of your peptide journey.

Welcome back to the Superhumanize Podcast. Today, we step into the radiant realm of healing, where ancient light meets modern science. My guest is Forrest Smith, a visionary at the intersection of wellness innovation and technology.As the founder of Kineon Labs and a former extreme athlete, Forrest brings decades of insight, both as a high-performing human and as a pioneering entrepreneur. His journey spans continents, from the rugby fields of South China to the tech corridors of North America. Along the way, he has built and sold multiple companies, delved deep into Chinese medicine and philosophy, and emerged with a powerful mission: to make cutting-edge red light therapy accessible, effective, and rooted in science.In this conversation, we explore what makes red light such potent allies for recovery, inflammation, performance, and even emotional well-being. We discuss photobiomodulation, how light interacts with our tissues at the molecular level, and why precise dosing truly matters. We also touch on the exciting future of light therapy for brain health, mood support, and energy optimization.Whether you are curious about pain management without pharmaceuticals, or interested in how light can nourish and heal the body, this episode will light the path.Episode highlights:02:00 – Forrest's journey from China-based tech entrepreneur and extreme athlete to mission-driven wellness innovator.04:00 – The founding vision of Kineon Labs: making high-quality red light and laser therapy devices accessible for home use.05:00 – Explanation of red light therapy and photobiomodulation—how light interacts with the body at a molecular level.07:00 – Why precise dosing matters: understanding the biphasic dose curve and photon absorption.09:00 – The role of nitric oxide and hemoglobin in increasing oxygen delivery and blood flow through light exposure.10:30 – How light affects mitochondrial function, oxidative stress, and inflammation on a cellular level.13:00 – Use of red light therapy in stroke recovery: extending the life of cells deprived of oxygen.14:00 – Designing devices backwards from desired biological outcomes instead of product features.17:00 – Why lasers outperform LEDs for dosing depth and precision.19:30 – Real-world outcomes from Kineon's Move+ device: high performance athletes, military, and aging populations.21:00 – Sustainable pain relief and mobility improvements for osteoarthritis and chronic injuries.24:00 – Long-term cardiovascular effects of untreated joint injuries—and how light therapy reverses them.27:00 – The power of stacking light therapy with stem cells, PRP, and shockwave treatments.31:00 – Protocols for joint pain and recovery: knees, backs, and sprains.39:00 – Forrest's favorite protocol: “Proximal Priority Therapy” for systemic inflammation and mood enhancement.41:00 – Transcranial light therapy and its promise for brain health, neurotransmitter balance, and immune resilience.44:00 – Future innovations: EEG and vagus nerve stimulation to support PTSD and autonomic regulation.50:00 – What's next: real-time brain energy mapping with single photon avalanche diodes.51:00 – Where to find Kineon products and community resources.Resources mentioned:Kineon Labs website – https://kineon.ioMove+ wearable...

BIO: Andy Sparks, PhD, was an academic in the UK for ~25 years and is now the Research Innovations Manager for Maurten AB, Sweden, and an Honorary Visiting Research Fellow at Liverpool John Moores University, UK. His research focuses on nutritional interventions to enhance sports performance, particularly the use of sodium bicarbonate. He has published extensively on a range of topics in exercise physiology and sports nutrition, with a particular interest in endurance cycling and running performance.Dr. Andy Sparks shares his expertise on sodium bicarbonate as an overlooked yet highly effective ergogenic aid for sports performance, with a particular focus on recent advances in delivery methods that minimize gastrointestinal distress. He explains the science behind bicarbonate supplementation and reveals why this supplement deserves more attention from athletes across multiple sports.Key Points!• Sodium bicarbonate is recognized as an A-list evidence-based supplement by the Australian Institute of Sport• Traditional delivery methods caused GI distress, giving the supplement a negative reputation despite its effectiveness• Works as an extracellular buffer that helps manage hydrogen ions during high-intensity exercise• May also reduce pain perception during exercise, explaining benefits in longer-duration events• Effective for high-intensity activities (400m-3000m races), intermittent sports, and even endurance events• Dosing varies widely (0.1-0.3g/kg bodyweight) with significant inter-individual response variability• Peak blood bicarbonate levels occur between 15-90 minutes post-ingestion, depending on delivery method• The Maurten bicarb system combines mini-tablets with a carbohydrate hydrogel to maximize effectiveness while minimizing GI issues• Safety concerns relate primarily to sodium load rather than bicarbonate itself• Particularly beneficial for race strategies with high-intensity starts followed by sustained effortsThe Maurten bicarb system is available online at maurten.com, with region-specific sites including a US option.

What if an anesthetic known for dental procedures could have a powerful effect on pain, inflammation, and nervous system regulation? Far beyond a numbing agent, Procaine is now being used as a powerful tool to reset the autonomic nervous system and treat chronic pain and stress at a cellular level.Joining me today is Lexi Yoo, a double board-certified Nurse Practitioner, IFM Certified Practitioner, and the founder of Yoo Direct Health. Learn more: @lexiyooNPYDH Training Academy: https://ydhacademy.com/In this conversation, we explore: • How Procaine IV works beyond anesthesia to influence the nervous, immune, and inflammatory systems • Why it may be one of the best-kept secrets for patients dealing with chronic stress, autoimmune issues, and lingering trauma • What the clinical research tells us after 20+ years of use in Europe and integrative clinics worldwide • And how to implement Procaine safely and effectively in modern clinical practice.Catch me at: Instagram: @doctorjones_doctorjones Become a patient: https://enovativewellness.com/ 

Text us a pool question!It's Floc It Friday, and Rudy's bringing the fire—along with borates, polyquats, and the brutal truth about mustard algae. In what might be our most packed episode to date, Rudy Stankowitz dives headfirst into the evolving mustard algae crisis in 2025—why your go-to treatment (sodium bromide) is now banned, how diatoms are getting smarter, and what you need to do to fight back.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Lawsuit filed against RFK Jr over vaccine policy changes; oral on-demand treatment approved for HAE; OTC cuffless blood pressure monitor gets greenlit; dosing schedule update for Alzheimer treatment; REMS requirement removed for endothelin receptor antagonist meds.

In this episode, Bernie and Anthony talk about some BIG changes in cytarabine dosing in AML consolidation after a recent practice changing article. Will this change your practice? Hunault, et al. NEJM. 2025.https://evidence.nejm.org/doi/full/10.1056/EVIDoa2400326

How tightly should you stick to a GA therapy's label? Which complement inhibitor do you pick and why? And which candidates are best suited for treatment? In part 1 of this 2-part series, moderator Judy Kim, MD, and panelists Sunir Garg, MD; Deepak Sambhara, MD, and Rishi Singh, MD, explore these questions in a brief (but enlightening) discussion. 

Navigating the complex landscape of patient safety requires vigilance, knowledge, and adaptability. Today's episode takes us on a journey through two critical safety concerns that exemplify the challenges anesthesiologists face in diverse clinical settings.We begin with an eye-opening exploration of cosmetic surgery safety in Colombia, which has emerged as a top global destination for aesthetic procedures. Despite performing nearly 500,000 cosmetic surgeries annually, Colombia faces alarming safety statistics—mortality rates potentially ten times higher than global averages for anesthesia-related deaths. This stark disparity highlights how regulatory gaps, substandard facilities, and inadequate patient selection can create perfect storms for adverse outcomes. The discussion illuminates how anesthesiologists can serve as safety champions by implementing rigorous standards and protocols.The conversation then pivots to a surprisingly common yet overlooked danger in pediatric anesthesia: the administration of oxymetazoline. What seems like a routine medication becomes hazardous when delivery systems designed for upright, conscious patients are used on supine, anesthetized children. Through practical demonstrations and creative problem-solving, we uncover how simple modifications to delivery methods—specifically using atomizers with precisely filled syringes—can prevent potentially dangerous overdoses and create standardized, position-independent dosing.Both topics underscore a central theme: anesthesia safety demands thoughtful adaptation of standards to fit unique circumstances. Whether dealing with international variations in practice or the specialized needs of pediatric patients, the commitment to "no one shall be harmed by anesthesia care" requires constant vigilance and innovation. We'd love to hear your experiences with similar challenges—have you encountered safety variations in different practice settings, or developed creative solutions to common problems? Visit APSF.org to explore our resources and join the conversation about advancing anesthesia patient safety worldwide.For show notes & transcript, visit our episode page at apsf.org: https://www.apsf.org/podcast/261-patient-safety-challenges-from-global-cosmetic-tourism-to-pediatric-medication-dosing/© 2025, The Anesthesia Patient Safety Foundation

Not quite live, but we tried... Dosing for the show... Female bodybuilder bludgeoned to death with a hammer. Husband arrested under suspicion... The two scoop breast implant style... Silly foam tits... When a chef dies of cardiac arrest at 55yo you may want to test to drugs - Anne Burrell... Matt Rife and his punchable face... Does canned food go bad if someone pees on it while it's still in it's can? Costco doesn't think so... The Sex Fest is back, we're not sure where though... What is butt plug bingo... Bonnie Blue update - Now getting arrested for a sexual stunt... You're hot now that you have lost some weight and people that knew you then are now paying attention... The top ten swinger states in the US... The secret lives of Mormon wives... When male friends come on to other male friends... A short lesson in intellectual property law. Don't mess with the mouse... A word on being illiterate and still graduating... Frat boys are really weak... Just be yourself... Guys, get a female wingman.

What if you could mimic the effects of exercise—without actually hitting the gym? In this episode, Dr. Jones sits down with Anthony Castore, one of the most respected performance and cellular medicine coaches in the country, to explore SLU-PP-332, a compound with powerful mitochondrial and metabolic benefits.Anthony is the founder of DRIVE Longevity Solutions and a Fellow of the SSRP Institute. With over 30 years of high-performance coaching and deep knowledge of cellular biology, he brings unmatched insight into how compounds like SLU-PP-332 can be used to optimize athletic performance, body composition, and even organ repair.We dive into ERR receptors, the PGC1α–AMPK–ERR axis, mitochondrial biogenesis, metabolic flexibility, parasympathetic fat burning, neuroprotective effects, and how to titrate dosing for both patients and elite athletes. Whether you're a clinician, biohacker, or fitness enthusiast, this episode is packed with science and strategy you can use.

If you're tired, wired, and in pain—this one's for you. Insomnia, stress, and chronic discomfort often show up together, and we tend to treat them like separate problems. But what if they all stem from something simple… and fixable?Lyndsay Soprano talks with Natalie Jurado, founder of Rooted In, about the quiet power of magnesium. Not the kind in chalky pills or powders that mess with your gut—but in a cream your body can actually absorb. Natalie shares how magnesium supports everything from sleep and anxiety to inflammation, energy, blood pressure, and even mood swings.They dig into how magnesium deficiency flies under the radar, why it's often misdiagnosed, and how most of us—kids included—aren't getting enough. From ADHD to weight loss to workout recovery, magnesium plays a starring role in our well-being. And the truth is, food isn't always enough.This conversation is equal parts science and real talk. It's about understanding your body, getting ahead of burnout, and giving your nervous system the support it's been quietly begging for.Tune in if you've tried everything for your pain, sleep, or stress—and nothing's worked. This might be the missing piece.Find Natalie Jurado Online Here:Website: berootedin.comInstagram: @berootedinFacebook: Rooted InLinkedIn: Natalie JuradoFind The Pain Game Podcast Online Here:Website: thepaingamepodcast.comInstagram: @thepaingamepodcastFacebook: The Pain Game PodcastLinkedIn: Lyndsay SopranoYouTube: The Pain Game PodcastEpisode Highlights:(00:00) Introduction to Chronic Pain and Healing(01:16) The Connection Between Insomnia, Pain, and Stress(02:41) Exploring Magnesium for Relief(03:38) Understanding Magnesium: The Essential Mineral(07:13) Personal Journeys with Insomnia and Anxiety(12:24) Creating Effective Magnesium Products(15:37) Benefits of Magnesium for Health(19:12) Magnesium and Cholesterol Management(20:21) Safe Usage and Dosing of Magnesium Cream(27:01) Magnesium's Role in Diabetes and Blood Sugar(28:05) Magnesium for Pain Relief(30:31) Final Thoughts and Encouragement

https://www.linktr.ee/manonthemounjaro Ozempic rare eye disease update The the race for once monthly dosing Big insurance wins incoming?!

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

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Kelley Palomino joins us to share her personal and clinical insights into the powerful, often misunderstood world of mega potency homeopathy. After being dismissed by conventional doctors during her own neurological health crisis, Kelley turned to remedies like Opium, Restox, Calc Fluor, and Hydrastis—discovering firsthand how correctly used high potencies can shift chronic conditions. She explains how dosage, timing, and emotional states all influence outcomes, and why practitioners need to think differently when working at this level of potency.   Episode Highlights: 02:45 - Kelley's Own Health Struggles 04:24 - Finding the Right Remedies 07:34 - Mega Potencies and Their Impact 08:44 - Dealing with COVID and a Car Accident 11:23 - Creating the Spine Chart 12:48 - Using Mega Potencies for Pain Relief 17:08 - Understanding the Sphenoid Bone 19:10 - Facial Symptoms and Remedies 22:41 - Dosing and Personal Experiences 29:04 - Final Thoughts and Reflections 29:50 - Homeopathy and Chiropractic Synergy 30:40 - The Power of Homeopathy in Physical Adjustments 31:01 - Personal Experiences with Homeopathy 32:02 - Exploring Kinesiology and Muscle Testing 34:03 - Mega Potencies in Homeopathy 40:20 - Understanding Different Potency Scales 44:51 - Practical Applications and Case Studies 48:17 - Addressing Heavy Metals and Detoxification About my Guests: Kelley Palomino is a classically trained homeopath and a proud graduate of the Academy of Homeopathic Education (AHE), an esteemed institution accredited by ACHENA and recognized for exceeding the standards required for National Board Certification through the CHC. Her practice, Restoring to Health With Homeopathy, was founded in 2022 with the mission of helping individuals restore wellness naturally, with a special focus on autoimmune disorders. Kelley's journey into homeopathy was deeply personal—born out of her own healing experience. It was through homeopathy that she found true restoration, and she now brings that same hope and commitment to every client she serves. While she is passionate about helping people from all walks of life, Kelley holds a special compassion for those navigating chronic illness and immune dysfunction. Kelley believes that healing is possible—and that homeopathy can be a powerful tool on that path.   Find out more about Kelley Website: https://www.restoringtohealth.com/   If you would like to support the Homeopathy Hangout Podcast, please consider making a donation by visiting www.EugenieKruger.com and click the DONATE button at the top of the site. Every donation about $10 will receive a shout-out on a future episode.   Join my Homeopathy Hangout Podcast Facebook community here: https://www.facebook.com/groups/HelloHomies Follow me on Instagram https://www.instagram.com/eugeniekrugerhomeopathy/   Here is the link to my free 30-minute Homeopathy@Home online course: https://www.youtube.com/watch?v=vqBUpxO4pZQ&t=438s   Upon completion of the course - and if you live in Australia - you can join my Facebook group for free acute advice (you'll need to answer a couple of questions about the course upon request to join): www.facebook.com/groups/eughom            

In today's episode we'll talk about L-Carnitine.  What is L-carnitine, what does it do, and why are more people choosing to inject it instead of taking it as a pill? Let's break it down.  L-carnitine is a compound made from the amino acids lysine and methionine, and its main job is helping your body turn fat into energy by shuttling fatty acids into your cells' mitochondria. While we naturally make some and get more from foods like red meat and dairy, certain people — like athletes, older adults, or those with metabolic issues — may not make or absorb enough. That's where supplementation, especially the injectable form, comes in. Why inject L-carnitine instead of taking it by mouth? This is a question I get all the time. Yes, you can take L-carnitine as a pill or powder. But here's the catch: when you take it orally, your body only absorbs about 15 to 20% of it. That means you'd need to take a whopping 4 to 5 grams daily just to get a therapeutic dose — and that often comes with unpleasant side effects, like bloating, diarrhea, and even that infamous fishy body odor, thanks to a byproduct called trimethylamine. Injectable L-carnitine skips all that. It's way more bioavailable — so you actually absorb and use what you inject. It's faster-acting, especially when you give it intramuscularly. And it's also easier on the gut, since it bypasses digestion and liver metabolism. With the injectable form, you get more targeted results, which is great for things like fat loss, athletic performance, or metabolic health. What are the potential benefits of L-carnitine? Let's talk about what L-carnitine actually does in your body—because honestly, it's pretty impressive.  First off, it helps you burn fat more efficiently by moving fatty acids into your cells' mitochondria to be used for energy. It can also boost endurance by delaying fatigue, and it supports faster recovery by reducing soreness and muscle damage after tough workouts.  On top of that, it improves blood flow and oxygen delivery to your muscles, which can lead to better pumps and overall performance. It even helps keep fat from building up in organs like your liver and heart, which is great for metabolic health. L-carnitine also plays a role in boosting metabolism and improving insulin sensitivity, especially for those with blood sugar issues. Some studies suggest it can support mental focus and even help with heart function in people with heart conditions. Not bad for a single supplement, right? What about dosing? Injectable L-carnitine doses usually fall between 200 to 1,000 mg per day, though some people aiming for fat loss or performance might go as high as 2,000 mg. Most people split the dose to make injections more comfortable and keep levels steady—like 500 mg in each shoulder, or half in the morning and half before a workout.  Timing really does matter, too. It tends to work best first thing in the morning when your body's ready to burn fat, or about 30 to 60 minutes before training when you need a boost in energy and fat oxidation. Just avoid taking it too late, since it can be pretty stimulating and might mess with your sleep. What are the potential side effects of L-carnitine? Overall, injectable L-carnitine is pretty well tolerated, but like anything, it's not completely free of side effects.  Some people might notice redness or soreness at the injection site, especially if their technique isn't spot-on. Mild nausea or headaches can pop up too, but they're usually short-lived and related to the dose.  That fishy body odor we talked about earlier? It's less common with injections than with pills, but it can still happen if your body has trouble breaking down carnitine. Taking it too late in the day might lead to insomnia since it ramps up your energy, and some folks notice an increased appetite—probably because their metabolism is kicking into high gear.  And if you're not staying hydrated or your electrolytes are off, you might get muscle cramps. Who shouldn't take L-carnitine? L-carnitine can be super helpful for energy and fat metabolism, but it's not right for everyone.  If you have low thyroid function, it might actually make your symptoms worse because it can interfere with how your body uses thyroid hormones. People with a history of seizures should also be cautious, since L-carnitine may increase seizure risk. And while it has some benefits for heart health, there's some debate about whether it could raise certain byproducts like TMAO that might increase heart disease risk—especially in people who already have heart issues. It can also interact with medications like warfarin, so if you're on a blood thinner, definitely check with your provider.  Also, anyone with kidney or liver problems should use it carefully, too, since those organs help process and eliminate it. Oh, and if you're pregnant, breastfeeding, or prone to insomnia, it's best to hold off or talk with your doctor first. Bottom line: L-carnitine can do a lot of good, but it's always smart to make sure it's the right fit for your body. That said, it's not for everyone. Dosing, timing, and safety all matter — so always work with a knowledgeable provider. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!

Episode 192: ADHD Treatment.  Jordan Redden (MSIV) explains the treatment of ADHD. Dr. Bustamante adds input about pharmacologic and non-pharmacologic treatments. Dr. Arreaza shares the how stimulants were discovered as the treatment for ADHD. Written by Jordan Redden, MSIV, Ross University School of Medicine. Comments and edits by Isabelo Bustamante, MD, and Hector Arreaza, MD. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction.ADHD is a chronic neurodevelopmental condition characterized by inattention, impulsivity, and/or hyperactivity. While it's often diagnosed in childhood, symptoms can persist well in adulthood. The treatment for ADHD is multifaceted. It often includes medication, behavioral therapy, environmental modifications, and sometimes educational interventions which are especially effective in younger patients. Ongoing evaluation is needed during treatment. Treatment needs adjustments over time.Starting with medications: Stimulants are the most well-studied and effective pharmacologic treatment for ADHD. These include methylphenidate-based medications such as Ritalin, Concerta, and Focalin, and amphetamine-based options, like Adderall, Vyvanse, and Dexedrine. Discovery of stimulants for ADHD> Dr. Charles Bradley discovered stimulants as the treatment for ADHD around 1937. ADHD did not have a name at that time, but it was known that some children had behavioral problems related to poor attention and inability to control their impulses, but they were still intelligent. Dr. Bradley was a psychiatrist who was working in the Bradley Hospital (Rhode Island), he was studying these children and, as part of his experiments, they developed severe headaches. He gave “Benzedrine” (a decongestant) to his pediatric patients to treat severe headaches, and he discovered that Benzedrine improved academic performance and interest in school and improved disruptive behavior in some children.How do stimulants work.Stimulants work primarily by increasing dopamine and norepinephrine levels in the brain, which helps improve focus, attention span, and impulse control. They typically show a rapid onset of action and can lead to noticeable improvements within the first few days of use. Dosing is individualized and should start low with gradual titration. Side effects can include reduced appetite, insomnia, headaches, increased heart rate, and emotional lability.Types of stimulants. Stimulants come as short acting and long acting. They can come as a tablet, liquid, patch, or orally disintegrating tablet. After the discovery of Benzedrine as a possible treatment for ADHD, more research was done over the years, and Ritalin became the first FDA-approved medication for ADHD (1955). The list of medications may seem overwhelming, but there are only two types of stimulants used to treat ADHD: methylphenidate and amphetamine. Long-acting stimulant medications are often preferred for their consistent symptom control and lower potential for misuse. Vyvanse (lis-dexa-mfetamine) is a widely used long-acting amphetamine-based option. As a prodrug, it remains inactive until metabolized in the body, which results in a smoother onset and offset of action and may reduce the risk of abuse. This extended duration of effect can help patients maintain focus and regulate impulses throughout the day without the peaks and crashes sometimes seen with shorter-acting formulations. Of note, Vyvanse is also approved for Binge Eating Disorder. Many of these medications are Schedule II controlled substances, so to prescribe them you need a DEA license. Other long-acting options include Concerta, an extended-release methylphenidate, as well as extended-release versions of Adderall and Focalin. These are especially helpful for school-aged children who benefit from once-daily dosing, and for adults who need sustained attention during work or academic activities. The choice between short- and long-acting stimulants depends on individual response, side effect tolerance, and daily routine.For patients who cannot tolerate stimulants, or for those with contraindications such as a history of substance misuse or certain cardiac conditions, non-stimulant medications are an alternative. One of the most used is atomoxetine, which inhibits the presynaptic norepinephrine transporter (NET). This leads to increased levels of norepinephrine (and to a lesser extent dopamine). Guanfacine or clonidine are alpha-2A adrenergic receptor agonists that lead to reduced sympathetic outflow and enhanced prefrontal cortical function, improving attention and impulse control. These alpha agonists are particularly useful in younger children with significant hyperactivity or sleep disturbances.Non-pharmacologic treatments.Behavioral therapy before age 6 is the first choice, after that, medications are more effective than BH only, and as adults again you use CBT.Medication is often just one part of a broader treatment plan. Behavioral therapy, especially in children, plays a critical role. Parent-training programs, positive reinforcement systems, and structured routines can significantly improve functioning. And for adolescents and adults, cognitive-behavioral therapy (CBT) is particularly helpful. CBT can address issues like procrastination, time management, emotional regulation, and self-esteem which are areas that medication doesn't always touch.Using medications for ADHD can be faced with resistance by parents, and even children. There is stigma and misconceptions about mental health, there may be concerns about side effects, fear of addiction, negative past experiences, and some parents prefer to treat ADHD the “natural” way without medications or only with supplements. All those concerns are valid. Starting a medication for ADHD is the first line of treatment in children who are 6 years and older, but it requires a shared decision with parents and patients. Cardiac side effects are possible with stimulants. EKG may be needed before starting stimulants, but it is not required. Get a personal and family cardiac history, including a solid ROS. Benefits include control of current condition and treating comorbid conditions.The presentation of ADHD changes as the person goes through different stages of life. For example, you may have severe hyperactivity in your school years, but that hyperactivity improves during adolescence and impulsivity worsens. It varies among sexes too. Women tend to present as inattentive, and men tend to be more hyperactive. ADHD is often underdiagnosed in adults, yet it can significantly impact job performance, relationships, and mental health. In adults, we often use long-acting stimulants to minimize the potential for misuse. And psychotherapy, particularly CBT or executive functioning coaching, can be life-changing when combined with pharmacologic treatment. There are several populations where treatment must be tailored carefully such as pregnant patients, individuals with co-occurring anxiety or depression, and those with a history of substance use. For example, atomoxetine may be preferred in patients with a history of substance misuse. And in children with coexisting oppositional defiant disorder, combined behavioral and pharmacologic therapy is usually more effective than either approach alone.Comorbid conditions.Depression and anxiety can be comorbid, and they can also mimic ADHD. Consult your DSM-5 to clarify what you are treating, ADHD vs depression/anxiety.Treatment goes beyond the clinic. For school-aged children, we often work closely with schools to implement 504 plans or Individualized Education Programs (IEPs) that provide classroom accommodations. Adults may also benefit from workplace strategies like structured schedules, noise-reducing headphones, or even coaching support. Ongoing monitoring is absolutely essential. We assess side effects of medication, adherence, and symptom control. ***In children, we also monitor growth and sleep patterns. We often use validated rating scales, like the Vanderbilt questionnaire for children 6–12 (collect answers from two settings) or Conners questionnaires (collect from clinician, parents and teachers), to track progress. And shared decision-making with patients and families is key throughout the treatment process.To summarize, ADHD is a chronic but manageable condition. Effective treatment usually involves a combination of medication and behavioral interventions, tailored to the individual's needs. And early diagnosis and treatment can significantly improve quality of life academically, socially, and emotionally.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed., text rev. (DSM-5-TR). Washington, DC: American Psychiatric Association; 2022. CHADD (Children and Adults with Attention-Deficit/Hyperactivity Disorder). Understanding ADHD. Accessed May 2025. https://chadd.org National Institute for Health and Care Excellence (NICE). Attention Deficit Hyperactivity Disorder: Diagnosis and Management. NICE guideline [NG87]. Updated March 2018. Accessed May 2025. https://www.nice.org.uk/guidance/ng87 Pliszka SR; AACAP Work Group on Quality Issues. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894–921. doi:10.1097/chi.0b013e318054e724 Subcommittee on Children and Adolescents with Attention-Deficit/Hyperactivity Disorder, Steering Committee on Quality Improvement and Management. Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2019;144(4):e20192528. doi:10.1542/peds.2019-2528 Texas Children's Hospital. ADHD Provider Toolkit. Baylor College of Medicine. Accessed May 2025. https://www.bcm.edu Wolraich ML, Hagan JF Jr, Allan C, et al. Attention deficit hyperactivity disorder in children and adolescents: Overview of treatment and prognosis. UpToDate. Published 2024. Accessed May 2025.https://www.uptodate.comThe History of ADHD and Its Treatments, https://www.additudemag.com/history-of-adhd/Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. 

When we should use the bradycardia algorithm. The signs & symptoms of unstable bradycardia. Atropine's bradycardic dose and maximum. The use of atropine when a patient is in a second degree type II or third degree heart block.ECG changes that indicate subsequent doses of atropine are likely to be ineffective. The starting dose of Dopamine.The use of Dopamine for bradycardia as an interim until TCP vs hypotension.The use of Atropine and Dopamine in patients with myocardial ischemia. Podcasts with additional (advanced-provider level) information about bradycardia, Atropine, & Dopamine can be found on the Pass ACLS Pod Resources page.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Welcome to the podcast with Dr. Brendan McCarthy!   This episode takes you deep into the real-world practice of prescribing testosterone therapy for women. This is not a high-level overview—this is a nuts and bolts breakdown: ✅ Who it's for ✅ How it's dosed ✅ What labs to run ✅ What delivery methods are safest ✅ Why it's often done wrong—and how to get it right   With over 20 years of clinical experience, Dr. McCarthy shares the insights no seminar or textbook can offer, including the emotional and psychological challenges women face when beginning testosterone therapy, and the very real fears around side effects and community stigma.  

Next-generation anti-VEGF agents are designed for durability. But does that actually change the rate at which they're administered? David Miller, MD, joins us to review a pair of ARVO 2025 presentations that examined his clinic's real-world administration patterns for bevacizumab (Avastin, Genentech), faricimab (Vabysmo, Genentech/Roche), and high-dose aflibercept (Eylea HD, Regeneron). What were the differences—and did they really matter?  Also, Robert Wang, MD, helped us understand the state of play in the TKI pipeline as he shared data from the phase 2b ODYSSEY study. What are the latest data on CLX-AX (Clearside Biomedcial)? And where does it stack up against the other TKIs in the pipeline? Stick with us to find out. 

You're about to get the inside scoop on intersection between state-of-the-art performance enhancers and longevity ingredients.  You'll learn about overlooked molecules to build energy, mimic exercise, balance neurotransmitters, & bulletproof your nervous system. From the foundations like hydrating coconut compounds, to designer substances like paraxanthine, T2, SLU-PP-332, 5-amino-1MQ, JBSNF-0088, and DNF-10. In this episode, you'll learn how to upgrade your molecular routine with BioHarmonized, high-performance ingredients that energize without the crash. Meet our guest Kyal Van Der Leest is a Nutritionist, Naturopath & Functional Health Coach turned supplement formulator He founded LVLUP Health to create the kinds of products he wished he had access to during his clinical practice, retail experience & personal health journey. LVLUP's formulas blend evidence-based nutrition, functional medicine & various health modalities, targeting root causes & supporting multiple biochemical pathways With a results-driven approach, Kyal designs supplements that actually work as promised, offering effective tools for those seeking real, lasting wellness Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Using inferior pre-workout supplements hinders progress due to inactive ingredients & overstimulation Caffeine boosts performance but overstresses adrenals when overused, affecting gains & health Choosing the right form of B vitamins supports neurotransmitter synthesis & avoids toxicity High-quality ingredients lead to better supplement absorption & health benefits Newer stimulants like paraxanthin boost energy without causing adrenal fatigue Overloading one ingredient disrupts balance—use a well-rounded supplement approach Support thyroid health with safe supplements to improve energy & metabolism Regular detox practices like sauna use remove toxins &enhance performance Take supplements wisely to maximize nutrient absorption & effectiveness Supporting mitochondrial health boosts energy & resilience in modern life In animal studies, the peptide epitalon (a bioregulator peptide) has shown to increase lifespan by around 30% in rats/mice Some mainstream pre-workouts contain up to 500mg of caffeine per serving Episode Highlights 4:30 Why the Industry Uses Inferior Vitamin Forms 8:37 Problems With Traditional Pump Ingredients 10:38 Breakdown of LVLUP's Pre-Workout Formula 21:19 Methylene Blue for Mitochondria, EMF Protection & Formulas 29:01 Supporting Detox for Weight Loss & Fat Burners 44:19 Oral Bioavailability & Dosing of Peptides Links Watch it on YouTube: https://youtu.be/jtUtviSXcsU   Full episode show notes: outliyr.com/209 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

EP. 212: Today I'm joined by Dr. Spencer Nadolsky, obesity specialist, Lipidologist, and founder of Vineyard, a cutting-edge direct care platform. We're diving deep into the conversation you've been asking for: the real story behind GLP-1s, obesity as a chronic disease, and why treating it goes far beyond weight loss. We break down everything from proper dosing, common side effects, and the dangers of vanity prescribing to the systemic issues with telemedicine and PBMs. Dr. Nadolsky and I also discuss strength training, preserving muscle mass, and how GLP-1s may support metabolic and cardiovascular health beyond their FDA indications. This episode cuts through the noise and misinformation. If you care about metabolic health, this one's essential. Topics Discussed:  What are the real benefits of GLP-1 medications beyond weight loss? Is obesity truly a chronic disease, and how should it be treated? What are the risks of GLP-1 vanity dosing and fast titration? How do GLP-1s impact muscle mass and metabolic health? Why are telemedicine and PBMs problematic for obesity treatment? Sponsored By: Maui Nui Venison | Head to mauinuivenison.com/DRTYNA to secure your access now.  LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% Liver Love | Go to https://store.drtyna.com/products/liverlove Use code LIVER20 for 20% off On This Episode We Cover:  00:00:00 – Introduction  00:02:48 – GLP-1 Dosing  00:06:35 – Side Effects of Vanity Dosing 00:08:51 – Reducing GLP-1 Dosing 00:12:27 – Med Spas & Telemedicine Risks 00:14:20 – Slow Titration for Better Tolerance 00:18:44 – Pharma Profits & Overdosing 00:20:49 – Obesity Treatment Pre & Post GLP-1s 00:27:58 – Obesity Is a Chronic Disease 00:32:45 – Defining obesity  00:36:16 – The Role of Genetics in Obesity 00:38:59 – Lifestyle Factors Beyond Genetics 00:40:46 – Insurance Barriers & PBM Costs 00:44:37 – Anti-GLP-1 Bias in Healthcare 00:46:22 – Why Strength Training Matters 00:51:39 – New Doctors & Role of AI 00:53:38 – Protecting Muscle on GLP-1s 00:58:55 – No Shortcuts to Health 01:02:01 – The Vineyard Show Links: Glp-1s Can Help Employers Lower Medical Costs In 2 Years, New Study Finds Further Listening GLP1 Uncovered FREE 4 Part Video Series  Ozempic Done Right Playlist EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knap Check Out Dr. Spencer Vineyard Instagram Website Podcast Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unpack the complexities of dosing GLP-1 medications for metabolic health and weight management. Dr. Cooper emphasizes the importance of an individualized approach, debunking the myth that higher doses or faster titration always lead to better outcomes. The team addresses listener questions about how and when to increase doses, highlight the risks of rapid escalation, and discuss the nuanced ways these drugs impact metabolic health beyond just weight loss. Real-life experiences and thoughtful, science-backed guidance will help you navigate your own journey with metabolic dysfunction and medication.Key Takeaways:Dosing of GLP-1 medications should always be tailored to the individual, considering response, side effects, and other health factors—not just the speed of weight loss.Starting at the lowest dose and titrating slowly increases medication tolerance and long-term effectiveness.Lab markers such as A1C, glucose, cholesterol, and muscle mass are key indicators in determining if the medication and dosing are "working."Rapidly escalating to the highest dose can backfire, causing side effects and limiting future treatment options.Dieting mindsets and using medication solely as an appetite suppressant can lead to loss of lean mass and suboptimal health outcomes.Ongoing patient-provider relationships and regular lab work ensure medication strategies remain safe and effective.Personal Stories & Practical Advice:Andrea reflects on her initial desire for quick fixes and shares lessons learned about patience, nourishment, and long-term progress. Mark discusses insurance-driven medication switches and finding the “sweet spot” for dosing with Dr. Cooper's guidance.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

I'm back again for my fourth conversation with Dr. Mark Cronshaw, an expert in the world of photobiomodulation (PBM), aka red light therapy. You know that when I have multiple conversations with a guest, I highly value their knowledge and want to go deeper with what they have to share. If you want to get VERY technical and go deep with the topic of PBM, this episode is for you, and I recommend you listen to the prior 3 episodes we've recorded together.  In this conversation, Dr. Cronshaw presents what he calls his "philosophy of care" for using photobiomodulation to enhance healing, manage pain, and prevent injury. His approach focuses on a few fundamental questions:  Are you treating surface or deep tissues?  Are you seeking to stimulate healing/tissue repair or provide pain relief?  His multi-dimensional approach explains why different devices produce different results, enabling more strategic use of both professional and at-home light therapy tools.  

If you've been anywhere near health optimization circles, you already know Ben Greenfield as a NYT bestselling author, former Ironman triathlete, coach, one of the OGs of biohacking. Today, he's my guest on the Longevity podcast.   What we discuss: Ben's new home, cold exposure, and microdosing cryotherapy ... 00:06 Writing, updating, and revising “Boundless” ... 00:09 Key updates: Self-quantification, longevity, new detox protocols ... 00:12 High-tech blood filtration and its impact ... 00:15 Daily detox strategies: Lymphatic movement, sauna, exercise ... 00:17 Ben's evolution: From strict keto to Mediterranean-style eating ... 00:21 Genetics, ancestry, and personalized nutrition lessons ... 00:23 Impact of endurance training, hormone and gut issues, recovery via flexible dieting ... 00:27 Addressing high coronary plaque: Statins, PCSK9 inhibitors, supplementation ... 00:35 Tracking heart health non-invasively (CIMT) ... 00:38 Thoughtful, limited use of pharmaceuticals for health ... 00:44 Peptides: Orals, protocols, favorites (BPC-157, TA1, etc.) ... 00:47 GLP-1 agonists: Powerful but require careful dosing ... 00:51 Biohacks gone wrong: Dosing mishaps and psychedelic stories ... 00:55 Ben's three core tips: Family time, naps, and prayer ... 00:58   Our Amazing Sponsors: Wizard Sciences - Mitoblue Everything in the formula is there to help you think clearer, move better, and stay resilient mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng. Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase.   Mitolux NEW Second Generation - This second-generation red and near-infrared light therapy panel hits all the marks. Two new wavelengths—810nm and 940nm—target brain performance, deep muscle recovery, and circulation. I use GAMA mode when I want to lock in focus, and Fireplace 2 when I want to wind down. Get a Mitolux BTS2 Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout.   LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 10% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome to episode #982 of Six Pixels of Separation - The ThinkersOne Podcast. Ethan Kross is one of the sharpest minds on the planet when it comes to understanding how our emotions shape our thoughts, decisions, and relationships. As a professor of psychology and business at the University of Michigan and the author of the bestselling books Chatter and Shift - Managing Your Emotions - So They Don't Manage You, Ethan brings together rigorous research and practical insight in ways that are deeply human and immediately useful. In our conversation, we explore what it takes to manage emotions in a world that feels like it's dialed up to 11 - from doomscrolling and overstimulation to the growing cultural obsession with emotional transparency. Ethan challenges some of our most common assumptions about how emotions work (no, avoidance isn't always bad; yes, anger has a place) and makes the case for building a “diverse emotional toolkit” - strategies that are flexible, personal, and context-specific. We talk about the influence of technology, how AI might fit into the future of mental wellness, and why dosing your news intake might be as important as getting your steps in. For anyone feeling like their emotions are a little closer to the surface these days, Ethan offers not just understanding - but agency. Enjoy the conversation... Running time: 48:37. Hello from beautiful Montreal. Listen and subscribe over at Apple Podcasts. Listen and subscribe over at Spotify. Please visit and leave comments on the blog - Six Pixels of Separation. Feel free to connect to me directly on Facebook here: Mitch Joel on Facebook. Check out ThinkersOne. or you can connect on LinkedIn. ...or on X. Here is my conversation with Ethan Kross. Shift - Managing Your Emotions - So They Don't Manage You. Chatter. Follow Ethan on Instagram. Follow Ethan on X. Follow Ethan on LinkedIn. Chapters: (00:00) - Understanding Emotional Turbulence. (03:06) - The Toolbox of Emotion Management. (06:00) - The Misconception of Emotions. (09:00) - Collective Emotional Breakdown? (11:51) - The Role of Media in Emotional Perception. (14:45) - The Balance of Technology and Emotion. (18:06) - Navigating Emotional Overstimulation. (27:09) - Dosing the News for Better Wellbeing. (30:40) - Navigating Social Media and Emotional Health. (31:10) - Understanding Emotions and Meta-Emotions. (34:44) - The Shift from Self-Talk to Emotional Regulation. (38:00) - AI's Role in Emotional Management. (43:06) - Balancing Emotion Management and High Performance. (46:38) - Tools for Managing Emotions in Different Situations. (49:53) - The Power of Combining Emotional Tools.

In this information-packed episode of The Red Light Report, Dr. Mike Belkowski is joined by Josh Crawford, Clinical Director of Genoa Integrative Health & Wellness. Josh shares his transformational journey from emergency medicine to building one of the most robust red light therapy clinics in North America. Sparked by the tragic loss of his first wife to Crohn's disease and biologic-related cancer, Josh recounts how that experience ignited his pursuit of root-cause medicine, integrative therapies, and photobiomodulation.   The episode dives deep into the clinical application of red light therapy and methylene blue — especially in combination — as tools for mitochondrial repair, anti-aging, and chronic disease recovery. Josh and Dr. Mike explore the synergistic effects of methylene blue and red light, optimal dosing strategies, and the importance of high-quality supplementation. They also address the challenges of consumer devices, the biohacker movement, and using light and energy to promote cellular regeneration.   Topics include: •  Josh's journey from paramedic to bioenergetic health leader •  Why methylene blue + red light = mitochondrial magic •  Dosing strategies, contraindications, and clinical applications •  How to vet red light therapy devices and avoid snake oil •  Real-world stories of healing from autoimmune, cancer, and neurodegeneration   Whether you're a clinician, wellness entrepreneur, or biohacker, this episode is full of clinical pearls, personal insights, and practical protocols that highlight the future of medicine rooted in energy, light, and mitochondrial health.   Josh Crawford is the Clinical Director of Genoa Integrative Health & Wellness, a leading clinic focused on root-cause healing, mitochondrial repair, and advanced integrative therapies. With a background in emergency medicine and paramedicine, Josh transitioned into the world of holistic health after the tragic loss of his first wife to complications from Crohn's disease and biologic treatment. This personal turning point fueled his mission to challenge conventional sick-care models and pursue modalities that restore cellular health—especially photobiomodulation (red light therapy) and methylene blue. Today, Josh blends clinical insight with cutting-edge technologies to help patients reverse chronic illness, restore vitality, and reclaim their lives. He is widely respected for his hands-on expertise, patient-first philosophy, and ability to bridge traditional medical training with bioenergetic and integrative solutions.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :) As always, light up your health! - Key points: 00:00 – Introduction 03:18 – Career Shift: From Emergency Medicine to PBM Pioneer 07:05 – Building the Clinic: Canada's Red Light Hub 08:13 – Community Contrast: PBM vs. Conventional Medicine 09:26 – Mitochondria: The Root of Chronic Disease 10:23 – Methylene Blue Basics & Brain Boosting Benefits 11:31 – Red Light + Methylene Blue: Synergistic Power 12:41 – BioLight's Formula: What Makes It Different 13:36 – Why We Don't Say “Cure”: Focus on Balance 15:17 – Methylene Blue in Practice: Cancer & Chronic Cases 17:43 – Prevention > Treatment: The Case for Proactive Healing 20:57 – Synthetic Isn't Evil: Methylene Blue's History 23:25 – Clinical Data: 10,000+ Treatments, 0 Side Effects 25:02 – Empowering Patients: Education Over Blind Trust 26:22 – Curcumin + Methylene Blue: A Healing Combo 27:40 – Chronic Conditions: Extinguish the Fire First 28:08 – The Self-Healing Body: Set the Terrain 30:01 – Zero Harm: What 10,000 Doses Taught Us 31:12 – Inside the Clinic: What Patients Experience 33:27 – Food as Fuel: The Missing Piece in Healing 34:18 – Goldilocks Zone: The Ideal Red Light Dosage 35:19 – Energy & Frequency: Healing at a Cellular Level 37:01 – Frequency Therapy: Rife Tech & Signal Targeting 39:22 – Less is More: Why Overdoing Light Fails 41:28 – Beds Aren't Enough: Deep Healing Requires Precision 42:53 – Mobilizing Stem Cells with Light 44:34 – Brain Work: Lymph Flow & Drainage Support 46:22 – Consumer Devices: Why Most Don't Deliver 49:07 – Tech Specs: Pulsing, Power & What Really Matters 52:41 – The Red Light Market: Navigating Misinformation 55:13 – It's All About Dose: The Turkey Analogy 56:07 – Cooking the Tissue: Why Power Isn't Everything 58:13 – Class IV Lasers: Pain Relief vs. Real Healing 59:28 – Power ≠ Better: The Myth of “More is More” 1:00:08 – Lessons from 80,000+ Treatments 1:01:32 – Wrap-Up: Excitement Around New BioLight Capsules - Watch this episode on YouTube - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Save 25% when you Subscribe & Save to a BioBundle!   For a BioBundle, you choose:1.) Any one BioBlue supplement(BioBlue, BioBlue (SR), BioBlue Leuco, BioBlue Calm, BioBlue Capsules or BioBlue Leuco Capsules)2.) Any one BioC60 supplement(Regular or Concentrated)   The BioBundle automatically saves you 15% on both of the supplements you choose.You save an additional 10% by choosing to Subscribe & Save to that BioBundle.The 25% savings is passed along for every monthly delivery of your BioBundle!No discount code necessary!   Click here to check out The BioBundle - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

246: If you're dealing with gas, bloating, heartburn, constipation, or diarrhea, you're going to want to hear this conversation. I'm joined by Wade Lightheart, co-founder of BiOptimizers, to dive into real, actionable strategies you can start using today to optimize your digestion and feel better fast. We break down how digestive challenges can impact not just your gut, but also your brain function and overall quality of life through the gut-brain connection. I also share my own story of struggling with severe heartburn in college—and how addressing digestion can make a huge difference beyond just symptom relief. Go to bioptimizers.com/realfoodology for 10% off any order with code realfoodology Topics Discussed:  How can I naturally improve digestion and reduce symptoms like gas, bloating, and heartburn? What role do digestive enzymes and supplements play in gut health? How are digestion issues connected to brain fog and cognitive problems? What are the best ways to heal an inflamed gut and support overall digestive function? How do you choose high-quality digestive health supplements that actually work? Timestamps:  00:00:00 - Introduction  00:03:57 - The science of digestion  00:09:34 - Supplementation and chronic illness  00:12:14 - Animal studies  00:15:31 - Current research  00:17:56 - Surge in digestive issues  00:21:36 - Dosing enzymes  00:26:43 - Digesting protein & amino acids  00:30:14 - Improving digestion 00:32:08 - HCL production & immune strength  00:35:28 - High protein diet  00:37:55 - Healing an inflamed gut  00:43:23 - Product integrity  00:47:40 - Lifestyle change recommendations  00:50:30 - Find the diet that works for you  00:53:35 - Food allergies  00:56:41 - Advice for those struggling with gut problems 01:00:17 - Leaky gut  01:03:32 - How to find BIOptimizers  Sponsored By:  Go to bioptimizers.com/realfoodology for 10% off any order with code realfoodology Check Out Courtney:  LEAVE US A VOICE MESSAGE Check Out My new FREE Grocery Guide! @realfoodology www.realfoodology.com My Immune Supplement by 2x4 Air Dr Air Purifier AquaTru Water Filter EWG Tap Water Database Produced By: Drake Peterson

Listen to the full episode here: https://podcasts.apple.com/us/podcast/habits-and-hustle/id1451897026?i=1000674829479  Ever wondered if you're truly maximizing the benefits of your GLP-1 medication? In this Fitness Friday episode on the Habits and Hustle podcast, I talk with Dr. Tyna Moore to discuss getting the most out of GLP-1s like Ozempic - especially for women approaching or experiencing menopause. We dive into how to determine the right GLP-1 dosage for your body, why strength training is non-negotiable when taking these medications the surprising connections between hormones, pain management, and joint health.  Dr. Tyna is an expert in holistic regenerative medicine and resilient health with nearly three decades of experience in the medical world. Dr. Tyna brings a unique perspective to building robust health foundations, having graduated from the National College of Natural Medicine and the University of Western States Chiropractic College. She is also a #1 Best Selling author, international speaker, and host of The Dr Tyna Show Podcast.  What we discuss: How to determine the right GLP-1 dosage for your body Why strength training is non-negotiable when taking these medications The surprising connections between hormones, pain management, and joint health How GLP-1s can help with addiction issues beyond just food cravings Thank you to our sponsor: AquaTru: Get 20% off any purifier at aquatru.com with code HUSTLE Therasage: Head over to therasage.com and use code Be Bold for 15% off  TruNiagen: Head over to truniagen.com and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. BiOptimizers: Want to try Magnesium Breakthrough? Go to https://bioptimizers.com/jennifercohen and use promo code JC10 at checkout to save 10% off your purchase. Timeline Nutrition: Get 10% off your first order at timeline.com/cohen Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE for up to $300 off and a 3-year warranty on air purifiers.  Bio.me: Link to daily prebiotic fiber here, code Jennifer20 for 20% off.  Momentous: Shop this link and use code Jen for 20% off To learn more about Dr. Tyna Moore:  Ozempic Uncovered: https://www.drtyna.com/ozempicuncovered  Instagram: https://www.instagram.com/drtyna/ Youtube: https://youtube.com/@drtyna Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagements

Send us a textThis episode of Our MBC Life features Stephanie Walker and Julia Maués of the Patient-Centered Dosing Initiative team who have been working on the 2025 reboot of its groundbreaking 2020 patient survey. Julia and Stephanie break down how treatment doses are typically determined during clinical trials and why individualized dosing, based on more than your diagnosis, is so important for people living with metastatic breast cancer. They also chat about the newly launched 2025 Patient Dosing Survey that you can take right now, where to find it and why your experience about metastatic breast cancer treatment matters.Be sure and visit OurMBCLife.org  to check the episode notes for links and more information.

Drs. Pier Giorgio Cojutti and Navaneeth Narayanan join Dr. Megan Klatt to break down what you need to know about amoxicillin/clavulanate dosing. Tune in to learn more about the PK/PD of amoxicillin and clavulanic acid, how we landed on certain ratios for the treatment of common infections, strategies to optimize dosing for serious infections, and more! References: Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage. Clin Microbiol Infect. 2020 Jul;26(7):871-879. doi: 10.1016/j.cmi.2019.11.028. Epub 2019 Dec 4. PMID: 31811919. New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review. Clin Pharmacokinet. 2005;44(11):1097-115. doi: 10.2165/00003088-200544110-00001. PMID: 16231964. Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints. J Antimicrob Chemother. 2016 Oct;71(10):2909-17. doi: 10.1093/jac/dkw226. Epub 2016 Jun 20. PMID: 27330071. Augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent. J Antimicrob Chemother. 2004 Jan:53 Suppl 1:i3-20. doi: 10.1093/jac/dkh050. PMID: 14726431. Is the standard dose of amoxicillin-clavulanic acid sufficient? BMC Pharmacol Toxicol. 2014 Jul 21:15:38. doi: 10.1186/2050-6511-15-38. PMID: 25047044. MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae. J Antimicrob Chemother. 2017 May 1;72(5):1478-1487. doi: 10.1093/jac/dkw562. PMID: 28093484. Amoxicillin-Clavulanate Breakpoints Against Enterobacterales: Rationale for Revision by the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2024 Aug 16;79(2):516-523. doi: 10.1093/cid/ciae201. PMID: 38626241. Amoxicillin-Clavulanate Breakpoints Against Haemophilus influenzae: Rationale for Revision by the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2025 Feb 24;80(2):481-482. doi: 10.1093/cid/ciae246. PMID: 38709848. No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia. J Infect. 2024 Jun;88(6):106161. doi: 10.1016/j.jinf.2024.106161. Epub 2024 Apr 23. PMID: 38663754. Population pharmacokinetics and dosing simulations of amoxicillin in obese adults receiving co-amoxiclav. J Antimicrob Chemother. 2020 Dec 1;75(12):3611-3618. doi: 10.1093/jac/dkaa368. PMID: 32888018. Comprehensive guidance for antibiotic dosing in obese adults: 2022 update. Pharmacotherapy. 2023 Mar;43(3):226-246. doi: 10.1002/phar.2769. Epub 2023 Feb 18. PMID: 36703246.

I'm excited to share my conversation with Dr. Scott Sherr, where we dive deep into methylene blue - a compound you've probably seen all over social media lately (those blue tongues!). As someone whose primary research focuses on Alzheimer's disease, I was fascinated to explore the science behind this molecule that dates back to the 1870s and was actually the first drug registered with the FDA in 1897.  The most fascinating insight for me was learning how methylene blue can serve as an electron acceptor in our mitochondria - essentially functioning as a substitute for oxygen when our cells are under stress. This explains why it shows promise for everything from traumatic brain injury to cognitive enhancement and even as a potential alternative to stimulant medications.   If you're interested in optimizing brain performance, understanding mitochondrial health, or simply curious about this blue compound that's suddenly everywhere, this episode provides both the scientific foundation and practical applications you need. Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey.  SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you're looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMailTimestamps 00:00 Introduction 02:30 Methylene Blue's Role in Neurotransmitter Regulation 07:54 Mitochondrial Health and Methylene Blue 17:02 Methylene Blue and Modern Health Challenges 25:27 Methylene Blue in Hypobaric and Hyperbaric Environments 29:47 Understanding Hyperbaric Oxygen Therapy 32:27 Methylene Blue: A Mitochondrial Rescue 36:52 Bioavailability of Methylene Blue 42:17 Dosing and Applications of Methylene Blue 47:46 Combining Methylene Blue with Other Treatments 54:02 Conclusion and Further ResourcesThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Episode Highlights with McCall McPhersonHow GLPs were developed and how they became popular for weight lossWhat GLPs actually are and how they work The inflammatory pieces related to GLP use and her theory that they may reduce inflammationInflammation is a common factor in chronic disease but tough to pinpoint and affect, though easy to testShe measures HS-CRP on labs to check inflammation How she is seeing a consistent reduction in autoimmune antibodies with GLPsWhat to know about muscle loss with GLPs and how to maintain muscle mass if you take them: eat enough protein and strength-building activity Heart disease kills more people than all cancers combined A couple of important studies looking at cardiovascular death risk for diabetics on GLPs - 51% risk reduction with GLP useThe select trial in non-diabetics found a 21% reduction in heart attack and stroke risk with GLPsHow being undernourished and underhydrated can impact metrics like HRV and resting heart rate if people don't drink enough water on thisThe real data about thyroid risk and why this is really important to understand Dosing is so important and overdosing is responsible for the majority of issuesResources MentionedModern Weight Loss's: GLP-1's Decoded Guide McCall McPherson's website