Podcasts about Dosing

What if you could mimic the effects of exercise—without actually hitting the gym? In this episode, Dr. Jones sits down with Anthony Castore, one of the most respected performance and cellular medicine coaches in the country, to explore SLU-PP-332, a compound with powerful mitochondrial and metabolic benefits.Anthony is the founder of DRIVE Longevity Solutions and a Fellow of the SSRP Institute. With over 30 years of high-performance coaching and deep knowledge of cellular biology, he brings unmatched insight into how compounds like SLU-PP-332 can be used to optimize athletic performance, body composition, and even organ repair.We dive into ERR receptors, the PGC1α–AMPK–ERR axis, mitochondrial biogenesis, metabolic flexibility, parasympathetic fat burning, neuroprotective effects, and how to titrate dosing for both patients and elite athletes. Whether you're a clinician, biohacker, or fitness enthusiast, this episode is packed with science and strategy you can use.

If you're tired, wired, and in pain—this one's for you. Insomnia, stress, and chronic discomfort often show up together, and we tend to treat them like separate problems. But what if they all stem from something simple… and fixable?Lyndsay Soprano talks with Natalie Jurado, founder of Rooted In, about the quiet power of magnesium. Not the kind in chalky pills or powders that mess with your gut—but in a cream your body can actually absorb. Natalie shares how magnesium supports everything from sleep and anxiety to inflammation, energy, blood pressure, and even mood swings.They dig into how magnesium deficiency flies under the radar, why it's often misdiagnosed, and how most of us—kids included—aren't getting enough. From ADHD to weight loss to workout recovery, magnesium plays a starring role in our well-being. And the truth is, food isn't always enough.This conversation is equal parts science and real talk. It's about understanding your body, getting ahead of burnout, and giving your nervous system the support it's been quietly begging for.Tune in if you've tried everything for your pain, sleep, or stress—and nothing's worked. This might be the missing piece.Find Natalie Jurado Online Here:Website: berootedin.comInstagram: @berootedinFacebook: Rooted InLinkedIn: Natalie JuradoFind The Pain Game Podcast Online Here:Website: thepaingamepodcast.comInstagram: @thepaingamepodcastFacebook: The Pain Game PodcastLinkedIn: Lyndsay SopranoYouTube: The Pain Game PodcastEpisode Highlights:(00:00) Introduction to Chronic Pain and Healing(01:16) The Connection Between Insomnia, Pain, and Stress(02:41) Exploring Magnesium for Relief(03:38) Understanding Magnesium: The Essential Mineral(07:13) Personal Journeys with Insomnia and Anxiety(12:24) Creating Effective Magnesium Products(15:37) Benefits of Magnesium for Health(19:12) Magnesium and Cholesterol Management(20:21) Safe Usage and Dosing of Magnesium Cream(27:01) Magnesium's Role in Diabetes and Blood Sugar(28:05) Magnesium for Pain Relief(30:31) Final Thoughts and Encouragement

https://www.linktr.ee/manonthemounjaro Ozempic rare eye disease update The the race for once monthly dosing Big insurance wins incoming?!

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

VIEW ALL OF OUR LINKS: https://linktr.ee/manonthemounjaro JOIN OUR SUBSTACK: HTTP://WWW.ONTHEPEN.SUBSTACK.COM

Kelley Palomino joins us to share her personal and clinical insights into the powerful, often misunderstood world of mega potency homeopathy. After being dismissed by conventional doctors during her own neurological health crisis, Kelley turned to remedies like Opium, Restox, Calc Fluor, and Hydrastis—discovering firsthand how correctly used high potencies can shift chronic conditions. She explains how dosage, timing, and emotional states all influence outcomes, and why practitioners need to think differently when working at this level of potency.   Episode Highlights: 02:45 - Kelley's Own Health Struggles 04:24 - Finding the Right Remedies 07:34 - Mega Potencies and Their Impact 08:44 - Dealing with COVID and a Car Accident 11:23 - Creating the Spine Chart 12:48 - Using Mega Potencies for Pain Relief 17:08 - Understanding the Sphenoid Bone 19:10 - Facial Symptoms and Remedies 22:41 - Dosing and Personal Experiences 29:04 - Final Thoughts and Reflections 29:50 - Homeopathy and Chiropractic Synergy 30:40 - The Power of Homeopathy in Physical Adjustments 31:01 - Personal Experiences with Homeopathy 32:02 - Exploring Kinesiology and Muscle Testing 34:03 - Mega Potencies in Homeopathy 40:20 - Understanding Different Potency Scales 44:51 - Practical Applications and Case Studies 48:17 - Addressing Heavy Metals and Detoxification About my Guests: Kelley Palomino is a classically trained homeopath and a proud graduate of the Academy of Homeopathic Education (AHE), an esteemed institution accredited by ACHENA and recognized for exceeding the standards required for National Board Certification through the CHC. Her practice, Restoring to Health With Homeopathy, was founded in 2022 with the mission of helping individuals restore wellness naturally, with a special focus on autoimmune disorders. Kelley's journey into homeopathy was deeply personal—born out of her own healing experience. It was through homeopathy that she found true restoration, and she now brings that same hope and commitment to every client she serves. While she is passionate about helping people from all walks of life, Kelley holds a special compassion for those navigating chronic illness and immune dysfunction. Kelley believes that healing is possible—and that homeopathy can be a powerful tool on that path.   Find out more about Kelley Website: https://www.restoringtohealth.com/   If you would like to support the Homeopathy Hangout Podcast, please consider making a donation by visiting www.EugenieKruger.com and click the DONATE button at the top of the site. Every donation about $10 will receive a shout-out on a future episode.   Join my Homeopathy Hangout Podcast Facebook community here: https://www.facebook.com/groups/HelloHomies Follow me on Instagram https://www.instagram.com/eugeniekrugerhomeopathy/   Here is the link to my free 30-minute Homeopathy@Home online course: https://www.youtube.com/watch?v=vqBUpxO4pZQ&t=438s   Upon completion of the course - and if you live in Australia - you can join my Facebook group for free acute advice (you'll need to answer a couple of questions about the course upon request to join): www.facebook.com/groups/eughom            

In today's episode we'll talk about L-Carnitine.  What is L-carnitine, what does it do, and why are more people choosing to inject it instead of taking it as a pill? Let's break it down.  L-carnitine is a compound made from the amino acids lysine and methionine, and its main job is helping your body turn fat into energy by shuttling fatty acids into your cells' mitochondria. While we naturally make some and get more from foods like red meat and dairy, certain people — like athletes, older adults, or those with metabolic issues — may not make or absorb enough. That's where supplementation, especially the injectable form, comes in. Why inject L-carnitine instead of taking it by mouth? This is a question I get all the time. Yes, you can take L-carnitine as a pill or powder. But here's the catch: when you take it orally, your body only absorbs about 15 to 20% of it. That means you'd need to take a whopping 4 to 5 grams daily just to get a therapeutic dose — and that often comes with unpleasant side effects, like bloating, diarrhea, and even that infamous fishy body odor, thanks to a byproduct called trimethylamine. Injectable L-carnitine skips all that. It's way more bioavailable — so you actually absorb and use what you inject. It's faster-acting, especially when you give it intramuscularly. And it's also easier on the gut, since it bypasses digestion and liver metabolism. With the injectable form, you get more targeted results, which is great for things like fat loss, athletic performance, or metabolic health. What are the potential benefits of L-carnitine? Let's talk about what L-carnitine actually does in your body—because honestly, it's pretty impressive.  First off, it helps you burn fat more efficiently by moving fatty acids into your cells' mitochondria to be used for energy. It can also boost endurance by delaying fatigue, and it supports faster recovery by reducing soreness and muscle damage after tough workouts.  On top of that, it improves blood flow and oxygen delivery to your muscles, which can lead to better pumps and overall performance. It even helps keep fat from building up in organs like your liver and heart, which is great for metabolic health. L-carnitine also plays a role in boosting metabolism and improving insulin sensitivity, especially for those with blood sugar issues. Some studies suggest it can support mental focus and even help with heart function in people with heart conditions. Not bad for a single supplement, right? What about dosing? Injectable L-carnitine doses usually fall between 200 to 1,000 mg per day, though some people aiming for fat loss or performance might go as high as 2,000 mg. Most people split the dose to make injections more comfortable and keep levels steady—like 500 mg in each shoulder, or half in the morning and half before a workout.  Timing really does matter, too. It tends to work best first thing in the morning when your body's ready to burn fat, or about 30 to 60 minutes before training when you need a boost in energy and fat oxidation. Just avoid taking it too late, since it can be pretty stimulating and might mess with your sleep. What are the potential side effects of L-carnitine? Overall, injectable L-carnitine is pretty well tolerated, but like anything, it's not completely free of side effects.  Some people might notice redness or soreness at the injection site, especially if their technique isn't spot-on. Mild nausea or headaches can pop up too, but they're usually short-lived and related to the dose.  That fishy body odor we talked about earlier? It's less common with injections than with pills, but it can still happen if your body has trouble breaking down carnitine. Taking it too late in the day might lead to insomnia since it ramps up your energy, and some folks notice an increased appetite—probably because their metabolism is kicking into high gear.  And if you're not staying hydrated or your electrolytes are off, you might get muscle cramps. Who shouldn't take L-carnitine? L-carnitine can be super helpful for energy and fat metabolism, but it's not right for everyone.  If you have low thyroid function, it might actually make your symptoms worse because it can interfere with how your body uses thyroid hormones. People with a history of seizures should also be cautious, since L-carnitine may increase seizure risk. And while it has some benefits for heart health, there's some debate about whether it could raise certain byproducts like TMAO that might increase heart disease risk—especially in people who already have heart issues. It can also interact with medications like warfarin, so if you're on a blood thinner, definitely check with your provider.  Also, anyone with kidney or liver problems should use it carefully, too, since those organs help process and eliminate it. Oh, and if you're pregnant, breastfeeding, or prone to insomnia, it's best to hold off or talk with your doctor first. Bottom line: L-carnitine can do a lot of good, but it's always smart to make sure it's the right fit for your body. That said, it's not for everyone. Dosing, timing, and safety all matter — so always work with a knowledgeable provider. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Have a happy, healthy week!

When we should use the bradycardia algorithm. The signs & symptoms of unstable bradycardia. Atropine's bradycardic dose and maximum. The use of atropine when a patient is in a second degree type II or third degree heart block.ECG changes that indicate subsequent doses of atropine are likely to be ineffective. The starting dose of Dopamine.The use of Dopamine for bradycardia as an interim until TCP vs hypotension.The use of Atropine and Dopamine in patients with myocardial ischemia. Podcasts with additional (advanced-provider level) information about bradycardia, Atropine, & Dopamine can be found on the Pass ACLS Pod Resources page.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Episode 192: ADHD Treatment.  Jordan Redden (MSIV) explains the treatment of ADHD. Dr. Bustamante adds input about pharmacologic and non-pharmacologic treatments. Dr. Arreaza shares the how stimulants were discovered as the treatment for ADHD. Written by Jordan Redden, MSIV, Ross University School of Medicine. Comments and edits by Isabelo Bustamante, MD, and Hector Arreaza, MD. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction.ADHD is a chronic neurodevelopmental condition characterized by inattention, impulsivity, and/or hyperactivity. While it's often diagnosed in childhood, symptoms can persist well in adulthood. The treatment for ADHD is multifaceted. It often includes medication, behavioral therapy, environmental modifications, and sometimes educational interventions which are especially effective in younger patients. Ongoing evaluation is needed during treatment. Treatment needs adjustments over time.Starting with medications: Stimulants are the most well-studied and effective pharmacologic treatment for ADHD. These include methylphenidate-based medications such as Ritalin, Concerta, and Focalin, and amphetamine-based options, like Adderall, Vyvanse, and Dexedrine. Discovery of stimulants for ADHD> Dr. Charles Bradley discovered stimulants as the treatment for ADHD around 1937. ADHD did not have a name at that time, but it was known that some children had behavioral problems related to poor attention and inability to control their impulses, but they were still intelligent. Dr. Bradley was a psychiatrist who was working in the Bradley Hospital (Rhode Island), he was studying these children and, as part of his experiments, they developed severe headaches. He gave “Benzedrine” (a decongestant) to his pediatric patients to treat severe headaches, and he discovered that Benzedrine improved academic performance and interest in school and improved disruptive behavior in some children.How do stimulants work.Stimulants work primarily by increasing dopamine and norepinephrine levels in the brain, which helps improve focus, attention span, and impulse control. They typically show a rapid onset of action and can lead to noticeable improvements within the first few days of use. Dosing is individualized and should start low with gradual titration. Side effects can include reduced appetite, insomnia, headaches, increased heart rate, and emotional lability.Types of stimulants. Stimulants come as short acting and long acting. They can come as a tablet, liquid, patch, or orally disintegrating tablet. After the discovery of Benzedrine as a possible treatment for ADHD, more research was done over the years, and Ritalin became the first FDA-approved medication for ADHD (1955). The list of medications may seem overwhelming, but there are only two types of stimulants used to treat ADHD: methylphenidate and amphetamine. Long-acting stimulant medications are often preferred for their consistent symptom control and lower potential for misuse. Vyvanse (lis-dexa-mfetamine) is a widely used long-acting amphetamine-based option. As a prodrug, it remains inactive until metabolized in the body, which results in a smoother onset and offset of action and may reduce the risk of abuse. This extended duration of effect can help patients maintain focus and regulate impulses throughout the day without the peaks and crashes sometimes seen with shorter-acting formulations. Of note, Vyvanse is also approved for Binge Eating Disorder. Many of these medications are Schedule II controlled substances, so to prescribe them you need a DEA license. Other long-acting options include Concerta, an extended-release methylphenidate, as well as extended-release versions of Adderall and Focalin. These are especially helpful for school-aged children who benefit from once-daily dosing, and for adults who need sustained attention during work or academic activities. The choice between short- and long-acting stimulants depends on individual response, side effect tolerance, and daily routine.For patients who cannot tolerate stimulants, or for those with contraindications such as a history of substance misuse or certain cardiac conditions, non-stimulant medications are an alternative. One of the most used is atomoxetine, which inhibits the presynaptic norepinephrine transporter (NET). This leads to increased levels of norepinephrine (and to a lesser extent dopamine). Guanfacine or clonidine are alpha-2A adrenergic receptor agonists that lead to reduced sympathetic outflow and enhanced prefrontal cortical function, improving attention and impulse control. These alpha agonists are particularly useful in younger children with significant hyperactivity or sleep disturbances.Non-pharmacologic treatments.Behavioral therapy before age 6 is the first choice, after that, medications are more effective than BH only, and as adults again you use CBT.Medication is often just one part of a broader treatment plan. Behavioral therapy, especially in children, plays a critical role. Parent-training programs, positive reinforcement systems, and structured routines can significantly improve functioning. And for adolescents and adults, cognitive-behavioral therapy (CBT) is particularly helpful. CBT can address issues like procrastination, time management, emotional regulation, and self-esteem which are areas that medication doesn't always touch.Using medications for ADHD can be faced with resistance by parents, and even children. There is stigma and misconceptions about mental health, there may be concerns about side effects, fear of addiction, negative past experiences, and some parents prefer to treat ADHD the “natural” way without medications or only with supplements. All those concerns are valid. Starting a medication for ADHD is the first line of treatment in children who are 6 years and older, but it requires a shared decision with parents and patients. Cardiac side effects are possible with stimulants. EKG may be needed before starting stimulants, but it is not required. Get a personal and family cardiac history, including a solid ROS. Benefits include control of current condition and treating comorbid conditions.The presentation of ADHD changes as the person goes through different stages of life. For example, you may have severe hyperactivity in your school years, but that hyperactivity improves during adolescence and impulsivity worsens. It varies among sexes too. Women tend to present as inattentive, and men tend to be more hyperactive. ADHD is often underdiagnosed in adults, yet it can significantly impact job performance, relationships, and mental health. In adults, we often use long-acting stimulants to minimize the potential for misuse. And psychotherapy, particularly CBT or executive functioning coaching, can be life-changing when combined with pharmacologic treatment. There are several populations where treatment must be tailored carefully such as pregnant patients, individuals with co-occurring anxiety or depression, and those with a history of substance use. For example, atomoxetine may be preferred in patients with a history of substance misuse. And in children with coexisting oppositional defiant disorder, combined behavioral and pharmacologic therapy is usually more effective than either approach alone.Comorbid conditions.Depression and anxiety can be comorbid, and they can also mimic ADHD. Consult your DSM-5 to clarify what you are treating, ADHD vs depression/anxiety.Treatment goes beyond the clinic. For school-aged children, we often work closely with schools to implement 504 plans or Individualized Education Programs (IEPs) that provide classroom accommodations. Adults may also benefit from workplace strategies like structured schedules, noise-reducing headphones, or even coaching support. Ongoing monitoring is absolutely essential. We assess side effects of medication, adherence, and symptom control. ***In children, we also monitor growth and sleep patterns. We often use validated rating scales, like the Vanderbilt questionnaire for children 6–12 (collect answers from two settings) or Conners questionnaires (collect from clinician, parents and teachers), to track progress. And shared decision-making with patients and families is key throughout the treatment process.To summarize, ADHD is a chronic but manageable condition. Effective treatment usually involves a combination of medication and behavioral interventions, tailored to the individual's needs. And early diagnosis and treatment can significantly improve quality of life academically, socially, and emotionally.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed., text rev. (DSM-5-TR). Washington, DC: American Psychiatric Association; 2022. CHADD (Children and Adults with Attention-Deficit/Hyperactivity Disorder). Understanding ADHD. Accessed May 2025. https://chadd.org National Institute for Health and Care Excellence (NICE). Attention Deficit Hyperactivity Disorder: Diagnosis and Management. NICE guideline [NG87]. Updated March 2018. Accessed May 2025. https://www.nice.org.uk/guidance/ng87 Pliszka SR; AACAP Work Group on Quality Issues. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894–921. doi:10.1097/chi.0b013e318054e724 Subcommittee on Children and Adolescents with Attention-Deficit/Hyperactivity Disorder, Steering Committee on Quality Improvement and Management. Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2019;144(4):e20192528. doi:10.1542/peds.2019-2528 Texas Children's Hospital. ADHD Provider Toolkit. Baylor College of Medicine. Accessed May 2025. https://www.bcm.edu Wolraich ML, Hagan JF Jr, Allan C, et al. Attention deficit hyperactivity disorder in children and adolescents: Overview of treatment and prognosis. UpToDate. Published 2024. Accessed May 2025.https://www.uptodate.comThe History of ADHD and Its Treatments, https://www.additudemag.com/history-of-adhd/Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. 

Welcome to the podcast with Dr. Brendan McCarthy!   This episode takes you deep into the real-world practice of prescribing testosterone therapy for women. This is not a high-level overview—this is a nuts and bolts breakdown: ✅ Who it's for ✅ How it's dosed ✅ What labs to run ✅ What delivery methods are safest ✅ Why it's often done wrong—and how to get it right   With over 20 years of clinical experience, Dr. McCarthy shares the insights no seminar or textbook can offer, including the emotional and psychological challenges women face when beginning testosterone therapy, and the very real fears around side effects and community stigma.  

Next-generation anti-VEGF agents are designed for durability. But does that actually change the rate at which they're administered? David Miller, MD, joins us to review a pair of ARVO 2025 presentations that examined his clinic's real-world administration patterns for bevacizumab (Avastin, Genentech), faricimab (Vabysmo, Genentech/Roche), and high-dose aflibercept (Eylea HD, Regeneron). What were the differences—and did they really matter?  Also, Robert Wang, MD, helped us understand the state of play in the TKI pipeline as he shared data from the phase 2b ODYSSEY study. What are the latest data on CLX-AX (Clearside Biomedcial)? And where does it stack up against the other TKIs in the pipeline? Stick with us to find out. 

You're about to get the inside scoop on intersection between state-of-the-art performance enhancers and longevity ingredients.  You'll learn about overlooked molecules to build energy, mimic exercise, balance neurotransmitters, & bulletproof your nervous system. From the foundations like hydrating coconut compounds, to designer substances like paraxanthine, T2, SLU-PP-332, 5-amino-1MQ, JBSNF-0088, and DNF-10. In this episode, you'll learn how to upgrade your molecular routine with BioHarmonized, high-performance ingredients that energize without the crash. Meet our guest Kyal Van Der Leest is a Nutritionist, Naturopath & Functional Health Coach turned supplement formulator He founded LVLUP Health to create the kinds of products he wished he had access to during his clinical practice, retail experience & personal health journey. LVLUP's formulas blend evidence-based nutrition, functional medicine & various health modalities, targeting root causes & supporting multiple biochemical pathways With a results-driven approach, Kyal designs supplements that actually work as promised, offering effective tools for those seeking real, lasting wellness Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Using inferior pre-workout supplements hinders progress due to inactive ingredients & overstimulation Caffeine boosts performance but overstresses adrenals when overused, affecting gains & health Choosing the right form of B vitamins supports neurotransmitter synthesis & avoids toxicity High-quality ingredients lead to better supplement absorption & health benefits Newer stimulants like paraxanthin boost energy without causing adrenal fatigue Overloading one ingredient disrupts balance—use a well-rounded supplement approach Support thyroid health with safe supplements to improve energy & metabolism Regular detox practices like sauna use remove toxins &enhance performance Take supplements wisely to maximize nutrient absorption & effectiveness Supporting mitochondrial health boosts energy & resilience in modern life In animal studies, the peptide epitalon (a bioregulator peptide) has shown to increase lifespan by around 30% in rats/mice Some mainstream pre-workouts contain up to 500mg of caffeine per serving Episode Highlights 4:30 Why the Industry Uses Inferior Vitamin Forms 8:37 Problems With Traditional Pump Ingredients 10:38 Breakdown of LVLUP's Pre-Workout Formula 21:19 Methylene Blue for Mitochondria, EMF Protection & Formulas 29:01 Supporting Detox for Weight Loss & Fat Burners 44:19 Oral Bioavailability & Dosing of Peptides Links Watch it on YouTube: https://youtu.be/jtUtviSXcsU   Full episode show notes: outliyr.com/209 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

EP. 212: Today I'm joined by Dr. Spencer Nadolsky, obesity specialist, Lipidologist, and founder of Vineyard, a cutting-edge direct care platform. We're diving deep into the conversation you've been asking for: the real story behind GLP-1s, obesity as a chronic disease, and why treating it goes far beyond weight loss. We break down everything from proper dosing, common side effects, and the dangers of vanity prescribing to the systemic issues with telemedicine and PBMs. Dr. Nadolsky and I also discuss strength training, preserving muscle mass, and how GLP-1s may support metabolic and cardiovascular health beyond their FDA indications. This episode cuts through the noise and misinformation. If you care about metabolic health, this one's essential. Topics Discussed:  What are the real benefits of GLP-1 medications beyond weight loss? Is obesity truly a chronic disease, and how should it be treated? What are the risks of GLP-1 vanity dosing and fast titration? How do GLP-1s impact muscle mass and metabolic health? Why are telemedicine and PBMs problematic for obesity treatment? Sponsored By: Maui Nui Venison | Head to mauinuivenison.com/DRTYNA to secure your access now.  LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% Liver Love | Go to https://store.drtyna.com/products/liverlove Use code LIVER20 for 20% off On This Episode We Cover:  00:00:00 – Introduction  00:02:48 – GLP-1 Dosing  00:06:35 – Side Effects of Vanity Dosing 00:08:51 – Reducing GLP-1 Dosing 00:12:27 – Med Spas & Telemedicine Risks 00:14:20 – Slow Titration for Better Tolerance 00:18:44 – Pharma Profits & Overdosing 00:20:49 – Obesity Treatment Pre & Post GLP-1s 00:27:58 – Obesity Is a Chronic Disease 00:32:45 – Defining obesity  00:36:16 – The Role of Genetics in Obesity 00:38:59 – Lifestyle Factors Beyond Genetics 00:40:46 – Insurance Barriers & PBM Costs 00:44:37 – Anti-GLP-1 Bias in Healthcare 00:46:22 – Why Strength Training Matters 00:51:39 – New Doctors & Role of AI 00:53:38 – Protecting Muscle on GLP-1s 00:58:55 – No Shortcuts to Health 01:02:01 – The Vineyard Show Links: Glp-1s Can Help Employers Lower Medical Costs In 2 Years, New Study Finds Further Listening GLP1 Uncovered FREE 4 Part Video Series  Ozempic Done Right Playlist EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knap Check Out Dr. Spencer Vineyard Instagram Website Podcast Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unpack the complexities of dosing GLP-1 medications for metabolic health and weight management. Dr. Cooper emphasizes the importance of an individualized approach, debunking the myth that higher doses or faster titration always lead to better outcomes. The team addresses listener questions about how and when to increase doses, highlight the risks of rapid escalation, and discuss the nuanced ways these drugs impact metabolic health beyond just weight loss. Real-life experiences and thoughtful, science-backed guidance will help you navigate your own journey with metabolic dysfunction and medication.Key Takeaways:Dosing of GLP-1 medications should always be tailored to the individual, considering response, side effects, and other health factors—not just the speed of weight loss.Starting at the lowest dose and titrating slowly increases medication tolerance and long-term effectiveness.Lab markers such as A1C, glucose, cholesterol, and muscle mass are key indicators in determining if the medication and dosing are "working."Rapidly escalating to the highest dose can backfire, causing side effects and limiting future treatment options.Dieting mindsets and using medication solely as an appetite suppressant can lead to loss of lean mass and suboptimal health outcomes.Ongoing patient-provider relationships and regular lab work ensure medication strategies remain safe and effective.Personal Stories & Practical Advice:Andrea reflects on her initial desire for quick fixes and shares lessons learned about patience, nourishment, and long-term progress. Mark discusses insurance-driven medication switches and finding the “sweet spot” for dosing with Dr. Cooper's guidance.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

I'm back again for my fourth conversation with Dr. Mark Cronshaw, an expert in the world of photobiomodulation (PBM), aka red light therapy. You know that when I have multiple conversations with a guest, I highly value their knowledge and want to go deeper with what they have to share. If you want to get VERY technical and go deep with the topic of PBM, this episode is for you, and I recommend you listen to the prior 3 episodes we've recorded together.  In this conversation, Dr. Cronshaw presents what he calls his "philosophy of care" for using photobiomodulation to enhance healing, manage pain, and prevent injury. His approach focuses on a few fundamental questions:  Are you treating surface or deep tissues?  Are you seeking to stimulate healing/tissue repair or provide pain relief?  His multi-dimensional approach explains why different devices produce different results, enabling more strategic use of both professional and at-home light therapy tools.  

If you've been anywhere near health optimization circles, you already know Ben Greenfield as a NYT bestselling author, former Ironman triathlete, coach, one of the OGs of biohacking. Today, he's my guest on the Longevity podcast.   What we discuss: Ben's new home, cold exposure, and microdosing cryotherapy ... 00:06 Writing, updating, and revising “Boundless” ... 00:09 Key updates: Self-quantification, longevity, new detox protocols ... 00:12 High-tech blood filtration and its impact ... 00:15 Daily detox strategies: Lymphatic movement, sauna, exercise ... 00:17 Ben's evolution: From strict keto to Mediterranean-style eating ... 00:21 Genetics, ancestry, and personalized nutrition lessons ... 00:23 Impact of endurance training, hormone and gut issues, recovery via flexible dieting ... 00:27 Addressing high coronary plaque: Statins, PCSK9 inhibitors, supplementation ... 00:35 Tracking heart health non-invasively (CIMT) ... 00:38 Thoughtful, limited use of pharmaceuticals for health ... 00:44 Peptides: Orals, protocols, favorites (BPC-157, TA1, etc.) ... 00:47 GLP-1 agonists: Powerful but require careful dosing ... 00:51 Biohacks gone wrong: Dosing mishaps and psychedelic stories ... 00:55 Ben's three core tips: Family time, naps, and prayer ... 00:58   Our Amazing Sponsors: Wizard Sciences - Mitoblue Everything in the formula is there to help you think clearer, move better, and stay resilient mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng. Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase.   Mitolux NEW Second Generation - This second-generation red and near-infrared light therapy panel hits all the marks. Two new wavelengths—810nm and 940nm—target brain performance, deep muscle recovery, and circulation. I use GAMA mode when I want to lock in focus, and Fireplace 2 when I want to wind down. Get a Mitolux BTS2 Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout.   LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 10% off your order.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Welcome to episode #982 of Six Pixels of Separation - The ThinkersOne Podcast. Ethan Kross is one of the sharpest minds on the planet when it comes to understanding how our emotions shape our thoughts, decisions, and relationships. As a professor of psychology and business at the University of Michigan and the author of the bestselling books Chatter and Shift - Managing Your Emotions - So They Don't Manage You, Ethan brings together rigorous research and practical insight in ways that are deeply human and immediately useful. In our conversation, we explore what it takes to manage emotions in a world that feels like it's dialed up to 11 - from doomscrolling and overstimulation to the growing cultural obsession with emotional transparency. Ethan challenges some of our most common assumptions about how emotions work (no, avoidance isn't always bad; yes, anger has a place) and makes the case for building a “diverse emotional toolkit” - strategies that are flexible, personal, and context-specific. We talk about the influence of technology, how AI might fit into the future of mental wellness, and why dosing your news intake might be as important as getting your steps in. For anyone feeling like their emotions are a little closer to the surface these days, Ethan offers not just understanding - but agency. Enjoy the conversation... Running time: 48:37. Hello from beautiful Montreal. Listen and subscribe over at Apple Podcasts. Listen and subscribe over at Spotify. Please visit and leave comments on the blog - Six Pixels of Separation. Feel free to connect to me directly on Facebook here: Mitch Joel on Facebook. Check out ThinkersOne. or you can connect on LinkedIn. ...or on X. Here is my conversation with Ethan Kross. Shift - Managing Your Emotions - So They Don't Manage You. Chatter. Follow Ethan on Instagram. Follow Ethan on X. Follow Ethan on LinkedIn. Chapters: (00:00) - Understanding Emotional Turbulence. (03:06) - The Toolbox of Emotion Management. (06:00) - The Misconception of Emotions. (09:00) - Collective Emotional Breakdown? (11:51) - The Role of Media in Emotional Perception. (14:45) - The Balance of Technology and Emotion. (18:06) - Navigating Emotional Overstimulation. (27:09) - Dosing the News for Better Wellbeing. (30:40) - Navigating Social Media and Emotional Health. (31:10) - Understanding Emotions and Meta-Emotions. (34:44) - The Shift from Self-Talk to Emotional Regulation. (38:00) - AI's Role in Emotional Management. (43:06) - Balancing Emotion Management and High Performance. (46:38) - Tools for Managing Emotions in Different Situations. (49:53) - The Power of Combining Emotional Tools.

In this information-packed episode of The Red Light Report, Dr. Mike Belkowski is joined by Josh Crawford, Clinical Director of Genoa Integrative Health & Wellness. Josh shares his transformational journey from emergency medicine to building one of the most robust red light therapy clinics in North America. Sparked by the tragic loss of his first wife to Crohn's disease and biologic-related cancer, Josh recounts how that experience ignited his pursuit of root-cause medicine, integrative therapies, and photobiomodulation.   The episode dives deep into the clinical application of red light therapy and methylene blue — especially in combination — as tools for mitochondrial repair, anti-aging, and chronic disease recovery. Josh and Dr. Mike explore the synergistic effects of methylene blue and red light, optimal dosing strategies, and the importance of high-quality supplementation. They also address the challenges of consumer devices, the biohacker movement, and using light and energy to promote cellular regeneration.   Topics include: •  Josh's journey from paramedic to bioenergetic health leader •  Why methylene blue + red light = mitochondrial magic •  Dosing strategies, contraindications, and clinical applications •  How to vet red light therapy devices and avoid snake oil •  Real-world stories of healing from autoimmune, cancer, and neurodegeneration   Whether you're a clinician, wellness entrepreneur, or biohacker, this episode is full of clinical pearls, personal insights, and practical protocols that highlight the future of medicine rooted in energy, light, and mitochondrial health.   Josh Crawford is the Clinical Director of Genoa Integrative Health & Wellness, a leading clinic focused on root-cause healing, mitochondrial repair, and advanced integrative therapies. With a background in emergency medicine and paramedicine, Josh transitioned into the world of holistic health after the tragic loss of his first wife to complications from Crohn's disease and biologic treatment. This personal turning point fueled his mission to challenge conventional sick-care models and pursue modalities that restore cellular health—especially photobiomodulation (red light therapy) and methylene blue. Today, Josh blends clinical insight with cutting-edge technologies to help patients reverse chronic illness, restore vitality, and reclaim their lives. He is widely respected for his hands-on expertise, patient-first philosophy, and ability to bridge traditional medical training with bioenergetic and integrative solutions.   If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :) As always, light up your health! - Key points: 00:00 – Introduction 03:18 – Career Shift: From Emergency Medicine to PBM Pioneer 07:05 – Building the Clinic: Canada's Red Light Hub 08:13 – Community Contrast: PBM vs. Conventional Medicine 09:26 – Mitochondria: The Root of Chronic Disease 10:23 – Methylene Blue Basics & Brain Boosting Benefits 11:31 – Red Light + Methylene Blue: Synergistic Power 12:41 – BioLight's Formula: What Makes It Different 13:36 – Why We Don't Say “Cure”: Focus on Balance 15:17 – Methylene Blue in Practice: Cancer & Chronic Cases 17:43 – Prevention > Treatment: The Case for Proactive Healing 20:57 – Synthetic Isn't Evil: Methylene Blue's History 23:25 – Clinical Data: 10,000+ Treatments, 0 Side Effects 25:02 – Empowering Patients: Education Over Blind Trust 26:22 – Curcumin + Methylene Blue: A Healing Combo 27:40 – Chronic Conditions: Extinguish the Fire First 28:08 – The Self-Healing Body: Set the Terrain 30:01 – Zero Harm: What 10,000 Doses Taught Us 31:12 – Inside the Clinic: What Patients Experience 33:27 – Food as Fuel: The Missing Piece in Healing 34:18 – Goldilocks Zone: The Ideal Red Light Dosage 35:19 – Energy & Frequency: Healing at a Cellular Level 37:01 – Frequency Therapy: Rife Tech & Signal Targeting 39:22 – Less is More: Why Overdoing Light Fails 41:28 – Beds Aren't Enough: Deep Healing Requires Precision 42:53 – Mobilizing Stem Cells with Light 44:34 – Brain Work: Lymph Flow & Drainage Support 46:22 – Consumer Devices: Why Most Don't Deliver 49:07 – Tech Specs: Pulsing, Power & What Really Matters 52:41 – The Red Light Market: Navigating Misinformation 55:13 – It's All About Dose: The Turkey Analogy 56:07 – Cooking the Tissue: Why Power Isn't Everything 58:13 – Class IV Lasers: Pain Relief vs. Real Healing 59:28 – Power ≠ Better: The Myth of “More is More” 1:00:08 – Lessons from 80,000+ Treatments 1:01:32 – Wrap-Up: Excitement Around New BioLight Capsules - Watch this episode on YouTube - Upcoming BioLight Events:   Biohacking Conference - May 28 - 30 (Austin, TX)   Returning to Nature (Quantum Health Retreat), June 26 - 27 (Franklin, TN) - Save 25% when you Subscribe & Save to a BioBundle!   For a BioBundle, you choose:1.) Any one BioBlue supplement(BioBlue, BioBlue (SR), BioBlue Leuco, BioBlue Calm, BioBlue Capsules or BioBlue Leuco Capsules)2.) Any one BioC60 supplement(Regular or Concentrated)   The BioBundle automatically saves you 15% on both of the supplements you choose.You save an additional 10% by choosing to Subscribe & Save to that BioBundle.The 25% savings is passed along for every monthly delivery of your BioBundle!No discount code necessary!   Click here to check out The BioBundle - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

246: If you're dealing with gas, bloating, heartburn, constipation, or diarrhea, you're going to want to hear this conversation. I'm joined by Wade Lightheart, co-founder of BiOptimizers, to dive into real, actionable strategies you can start using today to optimize your digestion and feel better fast. We break down how digestive challenges can impact not just your gut, but also your brain function and overall quality of life through the gut-brain connection. I also share my own story of struggling with severe heartburn in college—and how addressing digestion can make a huge difference beyond just symptom relief. Go to bioptimizers.com/realfoodology for 10% off any order with code realfoodology Topics Discussed:  How can I naturally improve digestion and reduce symptoms like gas, bloating, and heartburn? What role do digestive enzymes and supplements play in gut health? How are digestion issues connected to brain fog and cognitive problems? What are the best ways to heal an inflamed gut and support overall digestive function? How do you choose high-quality digestive health supplements that actually work? Timestamps:  00:00:00 - Introduction  00:03:57 - The science of digestion  00:09:34 - Supplementation and chronic illness  00:12:14 - Animal studies  00:15:31 - Current research  00:17:56 - Surge in digestive issues  00:21:36 - Dosing enzymes  00:26:43 - Digesting protein & amino acids  00:30:14 - Improving digestion 00:32:08 - HCL production & immune strength  00:35:28 - High protein diet  00:37:55 - Healing an inflamed gut  00:43:23 - Product integrity  00:47:40 - Lifestyle change recommendations  00:50:30 - Find the diet that works for you  00:53:35 - Food allergies  00:56:41 - Advice for those struggling with gut problems 01:00:17 - Leaky gut  01:03:32 - How to find BIOptimizers  Sponsored By:  Go to bioptimizers.com/realfoodology for 10% off any order with code realfoodology Check Out Courtney:  LEAVE US A VOICE MESSAGE Check Out My new FREE Grocery Guide! @realfoodology www.realfoodology.com My Immune Supplement by 2x4 Air Dr Air Purifier AquaTru Water Filter EWG Tap Water Database Produced By: Drake Peterson

Listen to the full episode here: https://podcasts.apple.com/us/podcast/habits-and-hustle/id1451897026?i=1000674829479  Ever wondered if you're truly maximizing the benefits of your GLP-1 medication? In this Fitness Friday episode on the Habits and Hustle podcast, I talk with Dr. Tyna Moore to discuss getting the most out of GLP-1s like Ozempic - especially for women approaching or experiencing menopause. We dive into how to determine the right GLP-1 dosage for your body, why strength training is non-negotiable when taking these medications the surprising connections between hormones, pain management, and joint health.  Dr. Tyna is an expert in holistic regenerative medicine and resilient health with nearly three decades of experience in the medical world. Dr. Tyna brings a unique perspective to building robust health foundations, having graduated from the National College of Natural Medicine and the University of Western States Chiropractic College. She is also a #1 Best Selling author, international speaker, and host of The Dr Tyna Show Podcast.  What we discuss: How to determine the right GLP-1 dosage for your body Why strength training is non-negotiable when taking these medications The surprising connections between hormones, pain management, and joint health How GLP-1s can help with addiction issues beyond just food cravings Thank you to our sponsor: AquaTru: Get 20% off any purifier at aquatru.com with code HUSTLE Therasage: Head over to therasage.com and use code Be Bold for 15% off  TruNiagen: Head over to truniagen.com and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. BiOptimizers: Want to try Magnesium Breakthrough? Go to https://bioptimizers.com/jennifercohen and use promo code JC10 at checkout to save 10% off your purchase. Timeline Nutrition: Get 10% off your first order at timeline.com/cohen Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE for up to $300 off and a 3-year warranty on air purifiers.  Bio.me: Link to daily prebiotic fiber here, code Jennifer20 for 20% off.  Momentous: Shop this link and use code Jen for 20% off To learn more about Dr. Tyna Moore:  Ozempic Uncovered: https://www.drtyna.com/ozempicuncovered  Instagram: https://www.instagram.com/drtyna/ Youtube: https://youtube.com/@drtyna Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagements

Send us a textThis episode of Our MBC Life features Stephanie Walker and Julia Maués of the Patient-Centered Dosing Initiative team who have been working on the 2025 reboot of its groundbreaking 2020 patient survey. Julia and Stephanie break down how treatment doses are typically determined during clinical trials and why individualized dosing, based on more than your diagnosis, is so important for people living with metastatic breast cancer. They also chat about the newly launched 2025 Patient Dosing Survey that you can take right now, where to find it and why your experience about metastatic breast cancer treatment matters.Be sure and visit OurMBCLife.org  to check the episode notes for links and more information.

Are you feeling called to psychedelics? This is your official invitation to a psychedelic magic mushroom retreat with me in Mexico from Sep 10-16. Get all the details ⁠here⁠ and sign up for a free discovery call!My personal experiences with psychedelics have brought me so much healing and expansion! I've reversed my PTSD diagnosis, released shame and my inner critic, ignited my Intuition, and stepped into my power to create a life I LIKE. I share all those details in ep 242.Today, from Alexa you'll learn about:- What are the first, second, and third waves of psychedelics?- What's the historical use of plant medicine?- What's the neuroscience of psychedelics? What are they doing in the brain to help us?- What do different doses feel like? Microdosing vs. macrodosing?Free Resources- Feel how you want to feel NOW with my ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Free Desire Map⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠- FREE Masterclass: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discover Your Spiritual Gifts⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠- Sign up for a FREE 1:1 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠coaching curiosity call⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Let's Connect on⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!⁠⁠⁠⁠⁠Let's Go Deeper Together- Join the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Wild Wellness Women's Circle⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (monthly membership with sliding scale pricing)- Enroll in⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠Rewild Your Wellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (lifetime access online course)- Learn more about ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠one-on-one coaching⁠⁠⁠⁠

Drs. Pier Giorgio Cojutti and Navaneeth Narayanan join Dr. Megan Klatt to break down what you need to know about amoxicillin/clavulanate dosing. Tune in to learn more about the PK/PD of amoxicillin and clavulanic acid, how we landed on certain ratios for the treatment of common infections, strategies to optimize dosing for serious infections, and more! References: Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage. Clin Microbiol Infect. 2020 Jul;26(7):871-879. doi: 10.1016/j.cmi.2019.11.028. Epub 2019 Dec 4. PMID: 31811919. New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review. Clin Pharmacokinet. 2005;44(11):1097-115. doi: 10.2165/00003088-200544110-00001. PMID: 16231964. Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints. J Antimicrob Chemother. 2016 Oct;71(10):2909-17. doi: 10.1093/jac/dkw226. Epub 2016 Jun 20. PMID: 27330071. Augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent. J Antimicrob Chemother. 2004 Jan:53 Suppl 1:i3-20. doi: 10.1093/jac/dkh050. PMID: 14726431. Is the standard dose of amoxicillin-clavulanic acid sufficient? BMC Pharmacol Toxicol. 2014 Jul 21:15:38. doi: 10.1186/2050-6511-15-38. PMID: 25047044. MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae. J Antimicrob Chemother. 2017 May 1;72(5):1478-1487. doi: 10.1093/jac/dkw562. PMID: 28093484. Amoxicillin-Clavulanate Breakpoints Against Enterobacterales: Rationale for Revision by the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2024 Aug 16;79(2):516-523. doi: 10.1093/cid/ciae201. PMID: 38626241. Amoxicillin-Clavulanate Breakpoints Against Haemophilus influenzae: Rationale for Revision by the Clinical and Laboratory Standards Institute. Clin Infect Dis. 2025 Feb 24;80(2):481-482. doi: 10.1093/cid/ciae246. PMID: 38709848. No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia. J Infect. 2024 Jun;88(6):106161. doi: 10.1016/j.jinf.2024.106161. Epub 2024 Apr 23. PMID: 38663754. Population pharmacokinetics and dosing simulations of amoxicillin in obese adults receiving co-amoxiclav. J Antimicrob Chemother. 2020 Dec 1;75(12):3611-3618. doi: 10.1093/jac/dkaa368. PMID: 32888018. Comprehensive guidance for antibiotic dosing in obese adults: 2022 update. Pharmacotherapy. 2023 Mar;43(3):226-246. doi: 10.1002/phar.2769. Epub 2023 Feb 18. PMID: 36703246.

Send us a textHere is a supplement company Move Daily Fitness supports and where we get our product: Legion Athletics Supplements *This is an affiliate link. Discount code is MoveDaily Dr. Allan Bacon discusses the efficacy of supplements, how to source reputable companies, emphasizing the importance of reading labels and avoiding redundant products.00:01 Understanding dietary supplements, particularly for menopausal women.07:36 Reading supplement labels, and warning labels15:15 Is collagen worth the hype?22:53 Protein powders30:30 BCAA's and EAA's38:10 Creatine monohydrate and creatine hydrochloride45:48 Dosing creatine53:25 ProbioticsFollow Dr Allan Bacon:https://mauiathletics.com/Instagram: @drallanbacon Indemnity** All information provided by Move Daily Fitness and Tracy Steen is of a general nature and is furnished for educational/entertainment purposes only. No information is to be taken as medical or other health advice pertaining to any individual's specific health conditions. Move Daily is not engaged in rendering any medical services. Move Daily makes no guarantee regarding the accuracy, timeliness or relevance of any text, video or audio content. Any content provided is not a diagnosis, treatment plan or recommendation for a particular course of action regarding your health and it is not intended to provide specific medical advice. Do not delay in seeking the advice and diagnosis of a medical professional because of anything you may have read or interpreted from Move Daily Fitness content.  Consult your health care professional before participating in or acting on any recommendations found on Move Daily Fitness.  You agree, at your exposure, to indemnify and hold Move Daily Fitness and Tracy Steen harmless from any and all losses, liabilities and injuries, or damages resulting from and all claims, cause of action, suits, proceedings and demands against Move Daily Fitness and Tracy Steen, arising from or related to decisions or recommendations you make using Move Daily Fitness content. You agree that use of this information is at your own risk.Shop Legion Supplements and use discount code: MoveDailyThis is an affiliate link. The Move Daily Membership is a paid monthly subscription for women, which gives you access to a huge amount of resources to help support you in reaching your health goals. Whether you're looking to lose fat, gain lean muscle, focus on your nutrition, give time to wellness or simply wish to dial in your overall health, we can support you in achieving your objectives. Join today!Support the showThanks for moving daily with us in your fitness, wellness and nutrition! Be sure to follow us here:YouTube: https://www.youtube.com/@TracySteenMoveDailyInstagram: https://www.instagram.com/movedailyfitness/Facebook: https://www.facebook.com/tracy.steen1TikTok: https://www.tiktok.com/@tracysteenSubscribe to my podcast! https://www.buzzsprout.com/2375873/support

In this episode of the PFC Podcast, the discussion revolves around patient positioning during procedural sedation, the pharmacology and application of Versed (Midazolam), and the nuances of dosing in various clinical scenarios. The speakers emphasize the importance of having a plan for airway management, the physiological implications of patient positioning, and the amnestic effects of Versed in trauma and surgical settings. They share insights from their experiences in austere environments, highlighting the need for adaptability and careful consideration of patient responses to sedation. In this conversation, the speakers delve into the complexities of IV amnestics, particularly focusing on Propofol and Midazolam, and the challenges faced during sedation in anesthesia. They discuss the importance of monitoring patient comfort, the nuances of sedation versus analgesia, and the implications of using drugs like Ketamine and Versed. The conversation highlights the critical nature of assessing patient responses and the difficulties in managing sedation effectively, emphasizing that sedation is often more challenging than general anesthesia.TakeawaysPatient positioning is crucial during procedural sedation.Recovery position may enhance airway protection during sedation.Always have a plan for airway management in different positions.Versed is a GABA agonist that promotes sedation and amnesia.Dosing of Versed varies significantly based on patient condition.In trauma cases, lower doses of sedatives may be necessary.Communication with the patient is key when administering sedatives.Understanding the pharmacodynamics of Versed aids in effective use.Amnestic effects of Versed can be dose-dependent.Clinical experience plays a significant role in medication administration. IV amnestics like Propofol and Midazolam do not have a guaranteed amnestic dose.Sedation is one of the most challenging aspects of anesthesia.Monitoring vital signs is crucial during sedation to assess patient comfort.The physiological state of the patient significantly affects drug dosing.Ketamine is not considered an amnestic drug by some providers.Patient comfort is paramount, and sedation must be carefully managed.The use of narcotics can help manage discomfort during sedation.Understanding the patient's history, such as alcohol use, is important for dosing.Sedation requires constant assessment and adjustment of medications.The complexities of sedation often make it more difficult than general anesthesia.Chapters00:00 Introduction to Patient Positioning in Procedural Sedation09:57 Understanding Versed: Mechanism and Usage19:54 Dosing Strategies for Versed in Different Patient Scenarios29:54 Amnestic Effects and Clinical Considerations of Versed35:05 Understanding IV Amnestics: Propofol and Midazolam39:01 The Challenges of Sedation in Anesthesia45:26 Monitoring and Assessing Patient Comfort During Sedation51:27 Navigating the Complexities of Sedation and Analgesia57:55 The Role of Versed and Ketamine in Anesthesia01:01:39 Final Thoughts on Sedation Practices and Patient SafetyThank you to Delta Development Team for in part, sponsoring this podcast.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠deltadevteam.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠For more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠

I'm excited to share my conversation with Dr. Scott Sherr, where we dive deep into methylene blue - a compound you've probably seen all over social media lately (those blue tongues!). As someone whose primary research focuses on Alzheimer's disease, I was fascinated to explore the science behind this molecule that dates back to the 1870s and was actually the first drug registered with the FDA in 1897.  The most fascinating insight for me was learning how methylene blue can serve as an electron acceptor in our mitochondria - essentially functioning as a substitute for oxygen when our cells are under stress. This explains why it shows promise for everything from traumatic brain injury to cognitive enhancement and even as a potential alternative to stimulant medications.   If you're interested in optimizing brain performance, understanding mitochondrial health, or simply curious about this blue compound that's suddenly everywhere, this episode provides both the scientific foundation and practical applications you need. Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey.  SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you're looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMailTimestamps 00:00 Introduction 02:30 Methylene Blue's Role in Neurotransmitter Regulation 07:54 Mitochondrial Health and Methylene Blue 17:02 Methylene Blue and Modern Health Challenges 25:27 Methylene Blue in Hypobaric and Hyperbaric Environments 29:47 Understanding Hyperbaric Oxygen Therapy 32:27 Methylene Blue: A Mitochondrial Rescue 36:52 Bioavailability of Methylene Blue 42:17 Dosing and Applications of Methylene Blue 47:46 Combining Methylene Blue with Other Treatments 54:02 Conclusion and Further ResourcesThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Episode Highlights with McCall McPhersonHow GLPs were developed and how they became popular for weight lossWhat GLPs actually are and how they work The inflammatory pieces related to GLP use and her theory that they may reduce inflammationInflammation is a common factor in chronic disease but tough to pinpoint and affect, though easy to testShe measures HS-CRP on labs to check inflammation How she is seeing a consistent reduction in autoimmune antibodies with GLPsWhat to know about muscle loss with GLPs and how to maintain muscle mass if you take them: eat enough protein and strength-building activity Heart disease kills more people than all cancers combined A couple of important studies looking at cardiovascular death risk for diabetics on GLPs - 51% risk reduction with GLP useThe select trial in non-diabetics found a 21% reduction in heart attack and stroke risk with GLPsHow being undernourished and underhydrated can impact metrics like HRV and resting heart rate if people don't drink enough water on thisThe real data about thyroid risk and why this is really important to understand Dosing is so important and overdosing is responsible for the majority of issuesResources MentionedModern Weight Loss's: GLP-1's Decoded Guide McCall McPherson's website

Send us a message with this link, we would love to hear from you. Standard message rates may apply.The meteoric rise in demand for weight loss drugs has created widespread shortages, leading to the emergence of compounding pharmacies as an alternative source for these medications.• Compounding pharmacies create custom medications by combining, mixing, or altering ingredients to meet specific needs• Unlike FDA-approved medications, compounded drugs don't undergo the same rigorous safety and effectiveness reviews• Dosing errors with compounded weight loss medications have led to serious adverse events requiring hospitalization• Confusion between units, milliliters, and milligrams contributes to potentially dangerous dosing mistakes• Some compounding pharmacies add unproven ingredients like vitamins, L-carnitine, and NAD to their formulations• The long half-life of these medications (about one week) means overdose symptoms can persist for extended periods• Pharmaceutical companies have responded with direct-to-consumer models offering FDA-approved versions at reduced prices• Eli Lilly now offers Zepbound in vial form for approximately $499/month versus $1000+ for pen versions• Novo Nordisk's NovaCare pharmacy provides direct-to-patient delivery of Wegovy single-dose pens at similar price pointsPlease talk to your healthcare provider about what option might be right for you, as these medications require careful consideration and proper dosing is essential for safety.Support the showProduction and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers. Symptoms indicating a stable vs unstable patient. Common causes of tachycardia. Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInOther Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Save money on prescription medications for you and your pets: https://nationaldrugcard.com/ndc3506*Commissions may be earned from the above links.Good luck with your ACLS class!

In this episode of the Smarter Not Harder Podcast, Bracha Banayan, a seasoned healthcare professional and innovator in weight management, uncovers the untold truths behind GLP-1 drugs like Ozempic, Wegovy, and their competitors. Bracha shares her personal journey from battling unexpected weight gain to discovering how these medications can not only help with weight loss but also transform overall health by reducing inflammation, moderating blood sugar spikes, and even rewiring behavior through what she calls the “pause factor.” She also dives into the science, the art of proper dosing, potential side effects, and the critical role of lifestyle modifications and supportive ecosystems in achieving long-term success. Join us as we delve into: How GLP‑1 drugs work to slow gastrointestinal transit, moderate blood sugar spikes, and influence our brain's reward system The concept of the “pause factor” and how a delay in instant gratification can transform eating habits Dosing strategies—from starting low and titrating gradually to minimizing side effects while achieving sustainable weight loss The critical role of lifestyle modifications, including nutrition, exercise, and behavioral coaching, in complementing GLP‑1 therapy This episode is for you if: You're curious about innovative, medication-assisted approaches to weight management You want to understand the science behind GLP‑1 drugs beyond appetite suppression You're interested in learning how proper dosing and lifestyle changes can lead to long-term health benefits You're a healthcare professional or patient seeking a holistic and informed approach to obesity management You can also find this episode on… YouTube: https://youtu.be/edjn6024DGc Find more from Bracha Banayan: IVDRIPS: https://ivdrips.com/ HastyMeds: https://ivdrips.com/hastymeds Instagram: https://www.instagram.com/bracha_banayan/ LinkedIn: https://www.linkedin.com/in/bracha-banayan/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

⚠️ Disclaimer: This episode contains discussions about cannabis use, consumption methods, and its relationship with mental health and motherhood. This content is for educational and informational purposes only and is not intended as medical advice. Please consult a healthcare professional before making any health or lifestyle changes.In this fascinating and educational conversation, Mary Hendricks and Riley Kirk, a cannabis educator and scientist, dive deep into the realities, myths, and stigmas surrounding cannabis use, particularly in the context of motherhood, mental health, and wellness.They explore the differences between edibles, vaporization, and smoking, the importance of terpenes in cannabis effects, and how dosing plays a crucial role in having a positive experience. Mary and Riley also discuss the stigma surrounding cannabis use, the challenges of discussing it with medical professionals, and why education is the key to responsible and informed consumption.The episode also covers legal considerations, product safety, and common misconceptions about Delta-8, THCA, and other cannabis products that have gained popularity. If you're curious about how cannabis fits into motherhood, mental health management, or everyday wellness, this episode provides a judgment-free, research-backed conversation to help break down the barriers of stigma.

In this episode of the Longevity Podcast, I'm thrilled to be joined by industry innovator Michael Antonelli, Founder & CEO of Healthgevity. Together, we dive deep into cutting-edge strategies for optimizing metabolism, muscle health, and immunity.  Try Healthgevity and use promo code: NAT10.   What We discuss: Michael Antonelli's background and journey ... 00:07:41 The inspiration behind Healthgevity ... 00:10:24 Introduction to metabolic health ... 00:19:16 Discussion on Ignite 2.0 formulation ... 00:20:16 Dosing flexibility of Ignite 2.0 ... 00:23:48 DNF10 and its role in Ignite 2.0 ... 00:30:10 Building muscle with longevity supplements ... 00:31:09 Introduction to PeptiStrong and its benefits ... 00:32:33 The importance of gut health and immunity ... 00:41:43 Prime Gut Health formula details ... 00:42:15 Discussion on Biorepair ... 00:55:56 Introduction to Immuno Reboot ... 01:00:37 Importance of sleep and Serenity product ... 01:02:26 Details on Serenity formulation ... 01:05:00 Conclusion and where to find Healthgevity products ... 01:11:37   Our Amazing Sponsors: Young Goose L.A.D.R. Serum -  Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage while you go about your life. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Future-proof your face.   Quantum Upgrade - Imagine plugging yourself into a limitless power source. It's been rigorously tested and shown to improve blood flow, reduce stress, and boost cellular energy by up to 29%. Try it today at quantumupgrade.io/NAT and start running life, instead of life running you. Use code NAT10 to get a 15-day free trial on the All-in-One Frequency Bundle. Good through June 1st, 2025.   Wizard Sciences (Neural Rx) - Neural Rx isn't just about a quick boost. It's designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.   Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

I have been practicing regenerative medicine for nearly two decades, and I don't know why it hasn't taken off like I expected. I asked that question to Dr David Karli why he believes that is the case, and what he is doing to pioneer new techniques that produce better outcomes. This is a deep-dive, technical episode about the art and science of regenerative medicine, and in which situations it is the most appropriate model of care.Dr. David Karli is a renowned leader in the field of Regenerative Medicine. He is an internationally known physician entrepreneur and respected author and lecturer in the field, having dedicated over twenty years of his life to perfecting life altering orthobiologic procedures for his patients. Many of his patients are long standing and travel thousands of miles to seek his care. He opened the Karli Center in March 2023 in Miami to create a focused resource, specifically devoted to advancing and delivering biological therapies, easily accessible to both national and international patients.Join us as we explore:Clearing up the confusion around regenerative medicine - what it is, what's the goal, why it hasn't taken off like I believe it should and Dr Karli's practice of the art.Cellular dosing - what is is, how it works and why it is at the center of the Karli Center.Why it is misguided to to spend thousands and thousands on biohacking and therapies but you are not putting your OWN cells to work for you.Whether the meniscus can be regenerated.How functional medicine and regenerative medicine are going to intersect.Contact: Website - https://www.karlicenter.comSupport the showFollow Steve's socials: Instagram | LinkedIn | YouTube | Facebook | Twitter | TikTokSupport the show on Patreon:As much as we love doing it, there are costs involved and any contribution will allow us to keep going and keep finding the best guests in the world to share their health expertise with you. I'd be grateful and feel so blessed by your support: https://www.patreon.com/MadeToThriveShowSend me a WhatsApp to +27 64 871 0308. Disclaimer: Please see the link for our disclaimer policy for all of our content: https://madetothrive.co.za/terms-and-conditions-and-privacy-policy/

In the second edition of a special podcast series, CancerNetwork® spoke with Daniel Morgensztern, MD; Mary Ellen Flanagan, NP; and Janelle Mann, PharmD, BCOP, about the best practices for incorporating recently approved bispecific antibodies into cancer care. This discussion focused on clinical trial results, administration protocols, and adverse effect (AE) management strategies related to the use of tarlatamab-dlle (Imdelltra) for patients with small cell lung cancer (SCLC). Morgensztern is a professor of Medicine and the clinical director of Thoracic Oncology in the Division of Oncology at Washington University School of Medicine in St. Louis. Flanagan is a nurse practitioner in the Division of Thoracic Oncology at Washington University. Mann is a clinical oncology pharmacist at Siteman Cancer Center of Washington University School of Medicine and manager of Clinical Pharmacy Services at Barnes-Jewish Hospital. The conversation opened with Morgensztern highlighting tarlatamab's mechanism of action as an agent that targets DLL3. He then reviewed prior efficacy data that the therapy demonstrated in the phase 1 DeLLphi-300 trial (NCT03319940) and the phase 2 DeLLphi-301 trial (NCT05060016). Of note, the FDA approved tarlatamab as the first available T-cell engager immunotherapy for patients with extensive-stage SCLC who have progressed on prior platinum-containing chemotherapy in May 2024 based on data from the DeLLphi-301 trial. Additionally, Flanagan detailed strategies for monitoring and mitigating the most common AEs associated with tarlatamab in this patient population, which include cytokine release syndrome and immune effector cell–associated neurotoxicity syndrome. Mann then outlined considerations for properly dosing and administering the agent, highlighting factors that clinicians should keep in mind when continuing treatment in an inpatient or outpatient setting. The group also spoke about clinical decision-making related to patients who have brain metastases, which included processes for adjusting the dose of tarlatamab and sequencing the bispecific agent with radiotherapy. Reference FDA grants accelerated approval to tarlatamab-dlle for extensive stage small cell lung cancer. News release. FDA. May 16, 2024. Accessed March 14, 2025. https://tinyurl.com/48k34rw5

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/In this Q&A video, I dive deep into your peptides questions—from dosage comparisons and injection techniques to protocol stacks for endurance, recovery, muscle growth, and even hormone optimization.Below are the exact timestamps with each question I answered:0:00 – [Music Introduction]0:10 – Introduction & overview of the Q&A session1:59 – Five Amino 1 MQ: Liquid vs Pills Dosage Comparison3:02 – Peptide and Supplement Protocol for Endurance Events (50k, 50 mile, 100 mile)5:01 – SLU PP332: Injectable vs Oral – Which Is Better?5:20 – Best Peptides for Jiu-Jitsu Performance, Endurance, and Recovery6:22 – SLU PP332 Dosage for Endurance: When to Take It?7:16 – Best Stack for Pre and Post Training for Endurance and Performance8:14 – Best Way to Inject: Intramuscular vs Subcutaneous for Different Peptides9:01 – How to Inject If You Have Very Little Body Fat Left9:51 – Mixing Instructions for Pinealon10:15 – Reconstituting and Dosing a Blend of GHK, TB500, and BPC 15710:54 – Is Pre-loading Multiple Peptides in the Same Syringe Safe?11:29 – How to Use and Convert Doses with the Autopens12:34 – Which Blood Tests Should You Monitor While Using Peptides?13:12 – Peptides for Injury and Pain Relief14:01 – Best Peptides for Lower Back Pain and Localized Injections15:05 – Best Peptides for Tendon and Ligament Injuries15:18 – Peptides for Nerve Pain/Neuropathy15:58 – Is a BPC 157 Cream Effective for Sports Injuries?17:38 – Are GH Peptides Safe for a 20-Year-Old Baseball Pitcher?18:05 – Peptides for Muscle Growth at Age 20 (Tesmelone, CHC, etc.)18:36 – How to Cycle Off and What's the Best Replacement?19:00 – Optimal Micro Dosing for Matsi with Reatutide19:57 – Best Stack for Muscle Gain in a 45-Year-Old Woman on Tzapatide20:04 – Peptides for Building Muscle in Adults 55+24:03 – Should You Cycle Off GLP-1s or Stay on Them Long Term?26:44 – Why Do GLP-1s Stop Working and How Can You Restart Results?30:14 – Cervodide vs Trptide Ratutide: Similarities and Differences31:34 – Testosterone and High Hematocrit: Is TRT Safe?32:29 – Optimal Testosterone Levels for a 59-Year-Old Man34:02 – Can Adding Low-Dose Estradiol to TRT Improve Libido?34:18 – How Do I Manage RBC Levels on TRT?35:45 – What Can Post-Menopausal Women Take Instead of HGH and Test Cyp?36:00 – Peptides for Hair Regrowth in Women with Male Pattern Hair Loss49:30 – What's the Best Fat Loss Stack for Fasted Cardio?51:05 – How Does Cagrilintide Tide Fit Into Fat Loss Protocols?51:52 – Does BPC 157 in Angiogenesis Increase Cancer Risk?52:46 – Can MOTS-c and L-Carnitine Raise Heart Rate?52:54 – Injectable vs Oral L-carintiine: Which Is Better?53:07 – How to Adjust Dosing for a BPC and TB500 Blend53:44 – What Is SB01 for Degenerative Disc Disease?54:14 – Best Peptides for Lung Health (COPD, Flem, etc.)54:59 – Should You Take Peptides With Food or Before Meals?55:30 – How Can I Make Peptide Injections Less Painful?55:58 – Can BPC 157/TB500 Be Used as a Nasal Spray or an Eye Drop?56:38 – VIP: Nasal Spray vs Subcutaneous Injection – Which Is Better?

Ever wondered why you still feel sluggish despite a "healthy" lifestyle? In this episode, Jeff Hoyt breaks down how environmental toxins silently accumulate in the body & how zeolite acts as a powerful detox magnet. You'll learn the key differences between binders & chelators, common detox mistakes, & how to safely eliminate harmful substances without depleting essential minerals. Find out how & more in today's episode on “The Smarter Way to Detox” Meet our guest Jeff is a wellness enthusiast with the goal of helping people live healthier & happier lives through detox & smart living strategies. His current focus is on helping people effectively & efficiently remove toxic elements from their bodies using natural detox solutions like zeolite Jeff believes that zeolite is one of the most powerful, yet misunderstood & misused supplements on the market, & his goal is to provide education on how to effectively use this amazing tool for health recovery & improvement Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Zeolite is a powerful detox agent, but it's often misused Prioritize sleep & use various detox methods like chlorine dioxide to aid recovery & maintain health Oxidative therapies, once avoided, are now seen as beneficial when used responsibly, contrasting with long-term antioxidant use Zeolite works through a swap mechanism, selectively binding toxins while leaving essential nutrients intact Detoxing efficiently involves addressing daily toxins first, allowing the body to naturally release stored toxins Toxins might either cause or result from chronic illness, making efficient detox crucial for health recovery Episode Highlights 5:13 Oxidative vs. Antioxidant Therapies 10:48 Challenges of Detoxing 11:59 The Magic of Zeolite (ZeoCharge) 33:38 Dosing the Detox Magnet Links Watch it on YouTube:  https://youtu.be/Mv4Tg7CwwDg  Full episode show notes: mindbodypeak.com/199 Connect with Nick on social media Instagram Twitter YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

In this episode, Sharmeen Roy, PharmD, BCPS, Chief Strategy & Science Officer at DoseMeRx, discusses the power of precision dosing technology in optimizing pharmacy operations and improving patient outcomes. Learn how validated, EHR-integrated software is enhancing clinical efficiency, reducing errors, and personalizing medication management.

In this episode of 'The Sleep Edit', we dig into the topic of sleep supplements for children, specifically focusing on melatonin and magnesium. Melatonin and magnesium (and "calm" and "sleep" gummies in general) have become very popular among tired parents, but what is the actual evidence for these supplements? Are they safe? What do parents need to know? Timestamps 00:00 Introduction and Disclaimer 01:09 Welcome Back to the Sleep Edit 01:21 Melatonin and Magnesium: The Two Big Ms 04:24 Understanding Melatonin 06:14 Melatonin's Effects and Usage 09:45 Melatonin for Children: Considerations and Concerns 21:16 Dosing and Safety of Melatonin 28:15 Melatonin Concerns and Parental Thoughts 29:37 Safety and Alternatives to Melatonin 31:28 Introduction to Magnesium for Sleep 34:49 Magnesium's Role and Benefits 36:39 Challenges in Diagnosing Magnesium Deficiency 38:49 Magnesium Supplementation Studies 39:54 Magnesium for Children: Evidence and Recommendations 47:25 Magnesium Lotions and Creams: Fact or Fiction? 53:33 Final Thoughts and Practical Advice 55:44 Conclusion and Additional Resources Links

“Is melatonin bad for you?” is the most common question I get whenever I suggest melatonin.They've heard on a podcast (or read on a blog) the dangers of melatonin.And how you can become addicted to melatonin, wrecking your own body's ability to produce it if you take melatonin supplements.I totally understand the concern – no one wants to shut down their own melatonin production.If you've been convinced that this melatonin side effect is real – you've been duped.And in today's episode, you'll discover WHY this claim is not only false, but physically impossible.For everyone wondering “is melatonin bad for you?,” you're about to discover why melatonin is so powerful and much more than just a sleep aid. Its potential for regulating your body goes far beyond sleep given that it's produced in your skin and your gut.My guest today – Dr. Deanna Minich – has extensively studied melatonin to uncover its hidden potential to transform your health.Deanna Minich, PhD, is a nutrition scientist, educator, and author, with over twenty years of experience in academia and in the natural product industries, currently serving as Chief Science Officer at Symphony Natural Health. She has been active as a functional medicine clinician in clinical trials and in her own practice (Food & Spirit™).She is the author of six books on wellness topics, four book chapters, and over fifty scientific publications. Through her talks, workshops, groups, and in-person retreats, she helps people to transform their lives practically and artfully through nutrition and lifestyle.Today we'll cover a lot of ground so you can get the full picture of melatonin benefits!Let's dive in!In This Episode:What melatonin is and how it's produced in the bodySurprising discovery of melatonin in 1958Melatonin as a potent antioxidantHow melatonin supports brain detox during sleep (impacting neurodegenerative diseases risk)Melatonin role in gut health, immune function, and mitochondria healthIs melatonin bad for you and can melatonin supplements be addictive?Is melatonin in pregnancy safe?Melatonin dosing tipsWhat foods naturally contain melatonin?Quotes“Melatonin is not just a sleep molecule—it's an antioxidant, anti-inflammatory, and neuroprotective powerhouse.” – Dr. Deanna Minich“One molecule of melatonin can quench up to 10 free radicals, making it more potent than vitamin C as an antioxidant.” – Dr. Deanna MinichLinksFind Dr. Minich online | Instagram | FacebookHealthy Skin Show ep. 105: Can Melatonin Help Itchy Skin (So You Can Sleep)?Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrierMelatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn careMelatoninMelatonin – RxList

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

Please note: This episode was recorded before the LA WildfiresThe guys sit down with comedian, podcaster, and expert skier Chelsea Handler to discuss her new book I’ll Have What She’s Having and whether men’s volleyball exists. Plus, does Gavin have a weird morning routine? See omnystudio.com/listener for privacy information.

Drs. Henry “Chip” Chambers and Warren Rose join Dr. Megan Klatt to tackle rifampin dosing for gram-positive infections. In this episode, they break down rifampin synergy studies and discuss what is the optimal dosing of rifampin for challenging gram-positive bacterial cases, in particular Staphylococcus aureus infections with or without retained hardware/devices.   Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/ References: Deconstructing the Dogma: Systematic Literature Review and Meta-analysis of Adjunctive Gentamicin and Rifampin in Staphylococcal Prosthetic Valve Endocarditis. Open Forum Infect Dis. 2022 Oct 31;9(11):ofac583. doi: 10.1093/ofid/ofac583. PMID: 36408468. Effectiveness of adjunctive rifampicin for treatment of Staphylococcus aureus bacteraemia: a systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2023 Oct 3;78(10):2419-2427. doi: 10.1093/jac/dkad214. PMID: 37583062. Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone? Open Forum Infect Dis. 2022 Oct 31;9(12):ofac582. doi: 10.1093/ofid/ofac582. PMID: 36504699.

Long Head of the Tricep Exercises, Breaking Diet Plateau, Generic GH dose and timing for Hyperplasia - Blood Sweat & Gear Coaching Podcast 287 Coaches Skip Hill, Andrew Berry, Scott McNally CHAPTERS BELOW

OCD, or Obsessive Compulsive Disorder, is a debilitating condition that involves intrusive thoughts and time-consuming, repetitive behaviors. It impacts 80 million worldwide, 2-4% of the US population or 1 in 100 people here in the US.It can be difficult to overstate the suffering caused by OCD, not only for those with this condition but also for their family members. In addition to the distress caused by the obsessional thoughts and compulsions, there can be shame and loss - loss of more meaningful, purposeful, or pleasant thoughts and behaviors. and loss of time connecting with others or engaging in purposeful or enjoyable activities.Other conditions associated with obsessive-compulsive disorder include:* Body dysmorphic disorder* Skin picking* Trichotillomania (hair pulling)* Hoarding* Hypochondria* Olfactory reference syndrome (an irrational feeling or belief that one emits a foul smell and often attempts to remove the odor).It´s not unusual for someone with OCD to have other conditions, such as:* Other forms of anxiety* Depression* ADHD* Autism spectrum disorder* Eating disorders* TourettesResearch suggests that having OCD raises one´s vulnerability to developing dementia. Many other brain conditions, however, also appear to increase this vulnerability similarly.Treatment ChallengesOCD is particularly challenging to treat. Of those with OCD, 60% do not respond to typical therapies (often medication in combination with psychotherapy involving gradual exposure to that which is being avoided). Typical medications include:* SSRI´s (Selective Serotonin Reuptake Inhibitors) -e.g., sertraline, fluoxetine, fluvoxamine, citalopram, paroxetine* Tricyclic antidepressant - clomipramine* SNRI - (Serotonin and Norepinephrine Reuptake Inhibitor) - venlafaxine* Atypical antipsychotic medications are sometimes addedMedication is combined with CBT (Cognitive Behavioral Therapy), which involves exposure and response prevention, or CBT is used alone.As you can see, most medication approaches aim to increase serotonin activity. Serotonin, however, is just one of the neurotransmitters involved. What has become increasingly clear from the research is that OCD involves abnormal activity at the NMDA receptor - a glutamate receptor.NMDA & GlutamateThe NMDA receptor is found throughout the brain. Glutamate, the primary excitatory neurotransmitter in the central nervous system, binds to the NMDA receptor. NMDA and glutamate are involved in synaptic plasticity (creating neuronal connections), learning, memory, and motor function.The synapse is the space between communicating neurons. Presynaptic neurons release glutamate, which binds to the NMDA receptor on postsynaptic neurons. This results in a cascade of signaling events that lead to “neuronal excitation.” The problem arises when this receptor has too much (or too little) activity. In the case of OCD, there is too much activity.Implications* Dysregulation at the NMDA receptor appears to play a role in OCD, depression, PTSD, schizophrenia, bipolar disorder, and substance use disorders.* Weak memory extinction can result from high activity at the NMDA receptor. While memory is a good thing, we can have problems with too much memory - or rather, problems putting our memories aside. This can look like thoughts getting stuck, for example:* Intrusive thoughts in OCD* Flashbacks in PTSD* Delusions in psychotic disorders* Cravings in addiction.* Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and ALS, have also been linked to NMDA receptor malfunction.Methylation & NMDAThose who are undermethylated, especially those with OCD or addictions, have high activity at the NMDA receptor. To remind you, undermethylation is a biochemical process with many functions, including the breakdown of histamine, support of detoxification, and support of serotonin activity. When someone is undermethylated, they can tend to have allergies (from high histamine), be perfectionistic, competitive, strong-willed, have obsessive-compulsive tendencies, be ritualistic, have dietary inflexibility, and have high accomplishment or have family members with high accomplishment. Undermethylation can contribute to the low serotonin activity seen in OCD. Simply addressing undermethylation, like merely addressing serotonin, will only bring partial benefit. To address undermethylation, those of us trained by the Walsh Research Institute, use SAMe and/or methionine, B12, B6, magnesium, and antioxidants. We address this before starting methylation treatment for those with high homocysteine. But how can we also decrease activity at the NMDA receptor?Blocking NMDA & Normalizing Glutamate ActivityEsketamine or Ketamine, which has been getting much attention in recent years, can impact the brain in various ways; however, its primary mechanism is as an NMDA blocker or antagonist. For some, it can serve as a rapid-acting and highly effective antidepressant. It can also decrease OCD symptoms. Other NMDA-blocking drugs include memantine and dextromethorphan (combined with bupropion). Lamotrigine can decrease glutamate release and has been used as an adjunct medication for OCD.Nutrients, however, play an important role in the NMDA receptor. NAC or N-acetyl cysteine is a precursor to glutathione and, thus, an antioxidant. It is also anti-inflammatory and a binder for a particular toxin made by candida and mold. But, it is also a potent NMDA antagonist (decreases activity at NMDA) and has been shown to reduce obsessions and compulsions of OCD. It has also been studied in alcoholism, opiate addiction, cocaine abuse, gambling disorder, shopping disorder, cigarette addiction, and trichotillomania. It has been used by itself and as an adjunct to medication therapy. NAC has become part of the Walsh undermethylation nutrient protocols for those with OCD and/or addiction.Zinc also plays an important role in regulating functioning at the NMDA receptor. The Walsh Research Institute found that 90% of those with brain symptoms had relatively low zinc. Dosing of zinc is determined after testing plasma zinc levels using a narrow range (the Walsh/Pheiffer range differs from typical lab ranges). Zinc is checked in conjunction with copper. Zinc has been found to improve treatment response in those with OCD treated with SSRIs. Zinc can be depleted because of very high oxidative stress and/or high pyrroles, which also cause low B6. Because B6 is needed to make serotonin, pyrroles are also important to address if elevated.Inositol is a nutrient involved in the serotonin and glutamate signaling systems. It, too, is beneficial for OCD symptoms; however, it can require very high doses.The challenge of research, as you can see, is that these approaches are all looked at in isolation, as opposed to, for example, addressing undermethylation, optimizing zinc, decreasing activity at the NMDA and addressing sources of oxidative stress.Candida & MoldAside from undermethylation, low serotonin activity, and high activity at the NMDA receptor, those with OCD appear to have high oxidative stress, as is the case with most brain-related conditions. One of the more common sources of oxidative stress I see in my practice is candida overgrowth in the GI tract, which often follows antibiotic exposure and /or mold toxicity due to water damage causing seen or unseen toxic mold. Because mold and candida (yeast) thrive on sugar and a high-carb diet, symptoms can fluctuate with sugar or carb intake. How might candida and mold intersect with the NMDA receptor? Mold and yeast can contribute to high histamine states. Histamine can increase activity at the NMDA receptor. EstrogenFor women and teen girls that I see with OCD, there is often a fluctuation in their OCD symptoms with their cycle. Typically, their symptoms worsen during the times of the month when estrogen is the highest. This may be because estrogen can increase activity at the NMDA receptor.PANDAS & PANSWhen a child has an abrupt onset of OCD symptoms, PANDAS and PANS should be considered.* PANDAS = Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections* PANS = Pediatric Acute-Onset Neuropsychiatric SyndromePANDAS and PANS are autoimmune conditions, meaning the immune system is acting on the body, in this case, a part of the brain called the basal ganglia, that involves an acute onset of OCD symptoms. Other symptoms can include restricted eating, mood symptoms, regression in academic or social skills, and motor tics. While triggers are often viral, bacterial (strep in the case of PANDAS), candida,or other microbial source, what is underlying the dysregulated immune response to such microbes, in my experience, is mold toxicity. SummaryBecause OCD can be difficult to treat, my hope in sharing this information is to raise awareness that effective OCD treatments can require a multifaceted approach that includes:* addressing methylation (and high pyrroles if present) to improve serotonin activity* decreasing activity at the NMDA receptor* by optimizing zinc* using supplements or medication* addressing sources of inflammation and high histamine* address sources of oxidative stress - trauma, stress, toxins, inflammation If you find this information helpful and would like to help me get this out into the world, please consider sharing:As always, I welcome your comments, questions, and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter and podcast episode is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for yourself or others, including but not limited to patients you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Unfortunately, today's world is filled with misinformation about hormone replacement therapies (HRTs).  And often, our primary care docs don't have the expert knowledge to explore menopause symptoms, hormone testing, and HRT options with their patients. That's why Dr. Masghati joins me today, to dive deep into tons of research-backed hormone replacement therapies to aid you in smoother perimenopause and menopause transitions.  Because we all deserve to feel our best today, and every day from here on out.  Tired of getting your symptoms brushed off by your doctor? Or done with bandaid solutions that aren't a long-term fix?  Check out this podcast for all you need to know about navigating perimenopause and menopause symptoms with the right HRT options for you!  Salome Masghati, MD, FACOG Dr. Salome Masghati is a gynecologist with specialized training in minimally invasive surgery. After dealing with multiple symptoms and hormonal imbalances, she reclaimed her health and shifted her practice to a holistic, root-cause approach to care. Inspired by her experience, she now helps women address underlying hormonal issues to achieve optimal health and improved quality of life. IN THIS EPISODE Navigating early menopause & menopause  Hormones & effective Hormone Replacement Therapies  Hormone testing & staying on top of your levels  Debunking myths around HRTs  Hormone testing in early perimenopause  Dosing hormone replacement based on your symptoms  Hormonal changes and risks for chronic diseases  QUOTES “With the hormones, get them checked no matter what age you are, then you have a baseline. When you start feeling symptomatic, it's a matter of understanding what range you're at at your baseline”  “Whatever changes are happening, there are things going on with your hormones… don't wait until hot flashes to look [into HRT].”  “When the receptors recognize it, it will have the similar function in your body, which is why we're doing it to begin with. We're not trying to just cover symptoms to cover them up.”  RESOURCES MENTIONED Dr. Masghati's Instagram Dr. Masghati's Website Book a Consultation with Dr. Masghati HERE    RELATED EPISODES  #618: Bringing Awareness to Primary Ovarian Insufficiency, Early Menopause, Hrt and Metabolic Changes With Jessica Jones 579: Hormone Replacement Options and Hormone Testing for Women In Midlife + Self Advocacy for Optimal Health with Esther Blum #572: How To Know You Are in Perimenopause Including The 40+ Symptoms Associated with Declining Hormones #558: The Science Behind Ozempic and Important Facts About Glp-1 Agonists + Hormone Replacement for Women 40+ With Dr. Tyna Moore

An in depth look at Dr Dean St Marts experience with SLU-PP-332. Will mitochondrial support make Bodybuilding "too easy"? Then Hair Transplants in 2025 and Dean's recent experience. Learn all about the process today on BSG Coaching Podcast with Coaches Andrew Berry and Scott McNally wit guest Dr Dean St Mart TIME STAMPS BELOW 0:00 Teaser 0:30 Welcome Dr Dean St Mart 1:30 What is SLU-PP-332 3:00 SLU-PP-332 animal research 5:20 Getting bigger AND leaner 8:40 Cognitive Benefits 10:00 Optimizing Mitochondria in Prep 12:30 Scott is getting leaner without scale drop 16:00 Negative side effects? 19:40 Dosing experience 21:20 Does our knowledge make bodybuilding “too easy”? 25:40 Training strategies to not destroy yourself on diet 31:00 MOT C - what do you get from it? 36:20 Oral vs Injectable SLU-PP-332 38:30 SLU-PP-332 half life? 42:20 SLU-PP-332 onset after dosing 43:30 GLP-1 Meds : Going hypo but NOT hungry 45:00 Hair Transplants 48:00 5 mechanisms of hair loss 50:45 How Dean Picked a clinic 51:35 2 techniques of hair transplants 53:45 Creating a hairline 56:00 what to expect in the procedure 1:02:00 Recovery from the surgery 1:10:00 Logistics of getting to the Turkish Clinic 1:19:45 The Hair Restoring Podcast with Dean Peptide Affiliates : ✅ https://parabolicpeptides.com Code THINK10 for 10% off ✅ https://aminoasylum.shop/ref/122/ Code THINK for 20% off

Of all the topics covered during interventional radiology training, dosimetry education is often delayed until after IRs enter clinical practice. In this episode, Drs. Tyler Sandow and Sabeen Dhand host a roundtable discussion with experts on the dosimetry fundamentals that all Y90 operators should understand. They are joined by interventional radiologists Drs. Zachary Berman, Kirema Garcia-Reyes, and Siddharth Padia, who provide their expert insights. Physicians, nurses, nurse practitioners, and physician assistants can follow this link to earn CME / CE credits for completing an accredited learning activity related to this discussion: https://www.cmeuniversity.com/course/take/125736 --- This podcast is supported by an educational grant from: AstraZeneca https://www.astrazeneca.com/our-therapy-areas/oncology.html With additional support from: Boston Scientific https://www.bostonscientific.com/en-US/medical-specialties/interventional-radiology/interventional-oncology.html --- SYNPOSIS The group agrees that dosimetry is not a one-size-fits-all approach. Dosing strategies depend on factors such as tumor size, perfusion territory, underlying liver function, the choice between glass versus resin spheres, and treatment intent. These considerations are illustrated with real-life case examples. The doctors also explore voxel-based dosimetry, a method for calculating the amount of radiation absorbed by different parts of the tumor. They stress the importance of learning how to perform accurate dosage calculations. Finally, the conversation touches on data from major Y90 trials, current guidelines, and the evolving perspective on Y90 as a potential curative treatment, rather than merely a bridging therapy. --- TIMESTAMPS 00:00 - Introduction 01:59 - Dosimetry Education During Training 05:46 - Benefit of Individualized Dosing 11:01 - Complications from High Doses 15:19 - Dosage Calculation Cases 22:51 - Duration of Response to Y90 25:00 - Dosing Based on Treatment Intent 29:11 - Challenging Case Example 42:31 - Voxel-Based Dosimetry 45:15 - Using Dosimetry Software --- RESOURCES LEGACY Trial (Salem et al, 2021): https://pmc.ncbi.nlm.nih.gov/articles/PMC8596669/ Voxel-based tumor dose correlates to complete pathologic necrosis after transarterial radioembolization for hepatocellular carcinoma (Pianka et al, 2024): https://pubmed.ncbi.nlm.nih.gov/38913189/ RAPY90D Trial (Kappadath et al, 2023): https://jnm.snmjournals.org/content/64/supplement_1/P268 Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: updated 2022 recommendations from an international multidisciplinary working group (Salem et al, 2023): https://pubmed.ncbi.nlm.nih.gov/36114872/ International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres (Levillain, 2021): https://link.springer.com/article/10.1007/s00259-020-05163-5)

Send us a textBemiparin in neonatal thrombosis: therapeutic dosing and safety.Sanchez-Holgado M, Sampedro M, Zozaya C, Permuy Romero C, Alvarez-Garcia P, La Banda-Montalvo L, Nieto C, Pellicer A.J Perinatol. 2024 Dec 16. doi: 10.1038/s41372-024-02200-1. Online ahead of print.PMID: 39681735As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

HOPA Pharmacy Outcomes & Practice-Based Collaboration Survey: https://www.surveymonkey.com/r/MXNVRBR Dexamethasone Dosing Intensity in Multiple Myeloma: https://doi.org/10.1182/blood.2024025939 Talquetamab + Teclistamab: https://doi.org/10.1182/blood.2024025939 postMONARCH: https://doi.org/10.1200/JCO-24-02086