Podcasts about Dosing

Show NotesIn this special live episode from the 2025 North American Congress of Clinical Toxicology (NACCT), Ryan takes you inside the conference to hear directly from the researchers themselves. Covering 11 abstracts that span high-stakes management decisions, surprising case reports, and challenges to toxicology dogma, this year's highlights feature everything from amlodipine overdoses to naturopathic misadventures, metformin-associated blindness, and more. The show kicks off with a foreword from Ryan and Dr. Jon Cole (abstract co-chair for AACT) discussing some of their favorite research from the conference. If you couldn't make it to NACCT or just want to catch up on some of the most impactful new research in our field, this episode will give you a front-row seat. Check below for links to the published abstracts, the full list of studies discussed, and timestamps for where you can hear each one.Link to published abstract manuscriptForeword with Dr. Jon Cole 10:24 #7. Is beta blocker toxicity associated with hypoglycemia?Lead author: Dr. Megan Audette, MD17:58 #237. V-A ECMO as a treatment for vasoplegic shock in amlodipine poisoning: a comparisonLead author: Dr. Daniel Tirado, MD27:59 #247. Blocked but not beaten: ECMO's role in severe amlodipine toxicity – a poison center case seriesLead author: Dr. Carlos Saldarriaga, MD28:39 #26. Amlodipine double-dose therapeutic errors reported to Poison CentersLead author: Johanne Freeman30:19 #27. Dosing on the edge: unpacking inadvertent amlodipine ingestions reported to a single poison centerLead author: Dr. Tiana Patriarca, PharmD33:44 #292. Intravenous administration of sodium zirconium cyclosilicate resulting in deathLead author: Dr. Stephen Thornton, MD Researcher interviews43:57 – #21. Quantitative analysis of amlodipine removal by plasmapheresisGuest: Dr. Keahi Horowitz, MD – Acute and Intensive Care Research Award winner48:14 – #23. Relationship between reported ingestion dose and outcome in amlodipine poisoningGuest: Dr. Colleen Cowdery, MD51:18 – #24. Management of severe amlodipine toxicity with high-dose calcium aloneGuest: Dr. Vincent Ma, MDHigh dose norepinephrine in amlodipine overdose Case report of calcium death 56:37 – #70. Iatrogenic exposure to long-acting buprenorphine injectable in an opioid-naïve patientGuest: Dr. Conor Young, MD59:52– #182. Left in the dark: a case of blindness in the setting of metformin toxicityGuest: Dr. Madison Bombard, MD61:52 – #169. Just because it's natural doesn't mean it's safe: a case of pediatric toxicity from topical and herbal remediesGuest: Dr. Aria Darling, MD64:12 – #203. Serotonin syndrome after vaping MoocahGuest: Dr. Connor Murphy, MD66:47 – #307. Intravenous ozone autohemotherapy: a retrospective observational case seriesGuest: Nicole McLarty 71:06 – #134. Do they really need n-acetylcysteine? Exploratory analysis of outcomes in patients with elevated liver function

Should GA therapy start monthly—or is less-than-monthly treatment enough? In episode 3 of this New Retina Radio miniseries, moderator John Kitchens, MD joins David Eichenbaum, MD; Margaret Chang, MD, MS; and Ferhina Ali, MD, MPH, to share best practices in real-world GA care. The panel debates dosing strategy in light of long-term data, compares safety/efficacy considerations for pegcetacoplan vs avacincaptad pegol (including first-injection inflammation risk), and offers tips for initiating therapy in monocular patients. They also unpack evidence around AREDS vitamins and early experiences with photobiomodulation.This content is editorially independent, supported by Astellas Pharma.

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you'll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools used by elite thinkers, fighter pilots, and world leaders. This is not a sales pitch. It is an educational masterclass on how to upgrade your brain beyond what it can ever do naturally. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey takes you inside the full playbook of Modafinil, a prescription nootropic often called the “real Limitless pill.” With over 20 years of personal experience using it daily alongside biohacking stacks of supplements, fasting, ketosis, cold therapy, sleep optimization, and Danger Coffee, Dave explains why Modafinil is more than just a wakefulness drug. It is a brain optimization tool that supports mitochondrial energy, resilience, and cognitive clarity. Together with decades of research, Dave shows you how Modafinil compares to stimulants like Adderall and caffeine, why it was adopted by Air Force pilots and Wall Street executives, and how functional medicine strategies can help you safely integrate it into a broader biohacking and longevity stack. This is a masterclass in hacking cognition and performance, designed for anyone who wants a sharper brain, stronger metabolism, and a more resilient body. You'll learn: • How Modafinil works as a nootropic without overstimulating dopamine • The connection between mitochondria, neuroplasticity, and human performance • Why Modafinil may protect against brain aging and inflammation • How to dose, stack, and cycle Modafinil with supplements and nutrition • What to expect from Modafinil compared to stimulants like Adderall or caffeine • The risks, side effects, and who should avoid it This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a transparent look at the world's most famous cognitive enhancer. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Modafinil, Armodafinil, Adrafinil, Real Limitless pill, Smart drugs, Eugeroic drug, Nootropics for focus, Orexin activation, Dopamine modulation, Mitochondria ATP production, Neuroplasticity enhancers, Jet lag treatment, ADHD alternative, Poker player focus enhancer, Modafinil stack, Modafinil and L-theanine, Modafinil and NAD+, Modafinil side effects, Stevens Johnson syndrome risk, Alzheimer's prevention modafinil Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:22 — Origin of Modafinil • 3:48 — Personal Experience • 8:22 — What to Expect • 9:37 — What Is Modafinil • 16:09 — How Modafinil Works • 19:36 — Benefits & Cognitive Upgrades • 25:36 — Dosing, Stacking, and Usage Tips • 28:17 — Side Effects and Safety • 31:37 — Sourcing and Legal Aspects • 36:55 — Research and Future Uses • 42:17 — Stacking for Biohacking • 47:07 — Recap and Final Advice See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today, I'm sitting down with Alex Tarnava and Dr. Tyler LeBaron, two of the brightest minds pioneering the use of molecular hydrogen in health optimization. Alex, the innovative creator behind the open cup hydrogen tablet technology, and Dr. LeBaron, founder of the Molecular Hydrogen Institute, join me to shed light on why this tiniest molecule could be the secret weapon in your longevity toolkit. We dive into their personal stories—Alex's relentless search for relief from autoimmune symptoms, and Dr. LeBaron's early curiosity that led him to decades of hydrogen research and advocacy.   To learn more visit  inhaleh2.com/NAT. There is a special discount between 20% - 24% percent off, depending on your pre-order.   Episode Timestamps: What is molecular hydrogen? ... 00:00:31 Guest backgrounds and early hydrogen research ... 00:04:37 Hydrogen's biological role and health benefits ... 00:09:24 Alex's personal health journey and invention ... 00:16:24 Clinical trials and real-world benefits ... 00:26:01 Hydrogen as a selective antioxidant ... 00:34:20 Inflammation, mitochondria, and aging ... 00:45:47 Delivery methods: water, inhalation, bathing ... 00:58:16 Dosing tips and protocols ... 01:14:21 Inhalation machines: safety and efficacy ... 01:17:47 Safety, final advice, and resources ... 01:26:26   Our Amazing Sponsors: StemRegen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   Puori - It's minimally processed, made from pasture-raised cows' milk, and it's tested for over 200 contaminants every single batch. Go to Puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you'll get nearly a third off the price. OraltidePro- A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In today's video I unpack amlexanox—an old anti-inflammatory/allergy drug with surprising metabolic effects. I share my first encounter with it in the research-chem world, what I noticed subjectively, and then dive into mechanisms (IKKε/TBK1 inhibition, catecholamine resensitization, beige fat), rodent data, the Phase 2 human trial (150 mg/day), safety, dosing, who seems to respond best, and how I'm stacking it inside Bio Ignite. If your goal is fat loss with stubborn adipose inflammation, this is worth understanding.0:00 - Welcome + what today's video covers0:28 - How I first found “AM Lox” browsing catalogs1:06 - Cycling off SLU-PP-332 and first personal trial1:40 - Noticing dryness/ab definition; early under-dosing2:12 - 2025 “sugar diet” + hunting for FGF21 boosters2:40 - Finding data that amlexanox increases FGF213:02 - Literature dosage (100–150 mg) vs my early dose3:38 - Why I think it's a useful fat-loss rotation tool4:24 - Channel/hosting update + where to find my videos5:08 - Slides start: what amlexanox is/was used for6:00 - Core mechanism: IKKε/TBK1 → PDE3B → cAMP resistance7:16 - IL-6→STAT3 hepatic signaling + beigeing via FGF218:30 - Big-picture benefits: inflammation, insulin sensitivity, glycemia10:32 - Human data: Phase 2 trial (150 mg/day x 12 weeks)11:10 - Modest/variable weight change; who improved most12:37 - Practical takeaways: glycemia, liver fat, insulin sensitivity14:12 - Dosing in practice (50 mg caps, TID = 150 mg/day)15:12 - Responder phenotype: high adipose inflammation16:00 - Who benefits most + variability at similar body fat17:56 - Study roll-up and mechanism recap18:52 - Final thoughts, use-cases, and product note (Bio Ignite)19:54 - Thank you + where to grab the peptide cheat sheetWhat You'll LearnWhy amlexanox can “release the brakes” on fat-burning by inhibiting IKKε/TBK1 and restoring cAMP/catecholamine responsiveness.How it raises IL-6 transiently in adipose, activates STAT3 in the liver, suppresses gluconeogenesis, and increases FGF21 to promote beige fat programs.The mouse vs. human gap: robust fat loss in mice; in humans, clearer improvements in A1c, fructosamine, liver fat, insulin sensitivity—especially when adipose inflammation is high.Dosing used in the Phase 2 trial: 50 mg TID (total 150 mg/day) for 12 weeks.Safety snapshot: no serious AEs attributed to amlexanox in metabolic trials; most common was a transient rash.Timestamps (exact to the transcript)What you'll learn

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this powerful second interview, Dr. Latt Mansor returns to the podcast to share his personal 20+ lb fat loss transformation—and how he used ketones and strategic carb re-feeds to break through stubborn plateaus, curb hunger, and preserve lean muscle mass. NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with magnesium and vitamin B12. Get 20% off at puori.com/VANESSA We dive into: How to use ketones to improve fat loss quality (not just scale weight) Why Dr. Mansor says ketones helped him “lose fat without losing muscle” How carb re-feeds helped him overcome plateaus and support metabolic flexibility How ketones support appetite control, recovery, and training performance A new study showing ketones boost sprint output and reduce fatigue Ketones vs. GLP-1 drugs like Ozempic—how they compare for appetite suppression Dosing protocols for fat loss, fasting, and late-night cravings How ketones improve oxygen delivery, red blood cell production, and reduce cortisol The science behind ketones reducing muscle protein breakdown and supporting performance Ketones and the brain: supporting focus, anxiety, ADHD, and GABA signaling If you've hit a fat loss plateau—or want to preserve muscle while losing fat—this episode is packed with cutting-edge science and tools on how to use exogenous ketones and strategic carbs to support metabolic health, performance, and sustainable results. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Karen tackles a listener question about low-dose lithium. She reviews micro- vs. low-dose ranges, discusses forms like lithium orotate/aspartate and third-party-tested supplement options, and flags safety essentials such as toxicity symptoms, thyroid/kidney considerations, and when to loop in your clinician.Visit our website itchyandbitchy.com to read blog posts on the many topics we have covered on the show.

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the September 2025 Emergency Medicine Practice article, Emergency Department Management of Patients With Status Epilepticus Topic IntroductionFocus: Status Epilepticus in AdultsReference to recent pediatric episodeArticle authors: Dr. Marquez, Dr. Kaur, Dr. LayWhy Status Epilepticus MattersTeaching value and clinical challengeTeam-based care and multidisciplinary involvementGuidelines and EvidenceReview of major guidelines (International League Against Epilepsy, Neurocritical Care Society, American Epilepsy Society)Key trials: EcLiPSE, ConSEPT, ESETTUpdated definition of status epilepticusClassification and DiagnosisConvulsive vs. non-convulsive statusImportance of repeated neurologic examsDiagnostic challenges and mimics (e.g., syncope, psychogenic seizures)Etiology and WorkupAcute vs. non-acute causesCommon triggers: medication noncompliance, metabolic issues, infections, traumaImportance of sleep patterns and ammonia levelsThe NORSE acronym (new onset refractory status epilepticus)Prehospital and ED ManagementAirway, breathing, circulation prioritiesEarly pharmacologic intervention (IM midazolam preferred in prehospital)Gathering history and medication informationPositioning and airway protectionDiagnosticsLaboratory workup: glucose, CBC, metabolic panel, drug levels, pregnancy testImaging: non-contrast CT, MRI, ultrasound, lumbar punctureEEG: spot vs. continuous monitoringTreatment ApproachFirst-line: Benzodiazepines (lorazepam, midazolam)Second-line: Levetiracetam, valproate, fosphenytoin, phenobarbital, lacosamideThird-line: Continuous infusions (midazolam, propofol, pentobarbital, thiopental, ketamine)Dosing pearls and importance of rapid escalationSpecial PopulationsPregnancy (eclampsia: magnesium as first-line)Substance-induced status epilepticus (e.g., isoniazid toxicity and pyridoxine)Brief mention of pediatric management and the PD stat appRisk Management PitfallsNon-convulsive status is common and easily missedImportance of weight-based dosingNeed for formal EEG in ambiguous casesDon't assume non-adherence is the only cause in known epilepticsAlways consider higher level of care for status patientsClinical PathwayStepwise approach to medication and escalationEmphasis on having a pathway/checklist for these high-stress casesConclusionRecap of key pointsThanks to authors and listenersReminder to visit ebmedicine.net for CME and resourcesEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/0:00 - Intro: why I'm covering Testagen0:30 - The low-T epidemic and TRT context1:12 - Why I'm excited about Testagen vs HCG2:00 - What I'll cover today (what it does, dosing, use cases)2:40 - What Testagen is (KEDG bioregulator peptide)3:12 - Mechanisms and “does this help women?” note4:00 - Core effects: endocrine support + epigenetic action5:00 - Target tissues: pituitary, thyroid, testes, bone marrow6:00 - Vascular/erectile benefits; “calibrating” the HPT axis6:30 - Fertility use case + my personal plan7:16 - Manufacturer indications; sexual function improvements8:12 - Case study: semen parameters quadrupled on Testolutin8:58 - Thyroid support, TBI/central hypo considerations9:58 - Anti-aging & immune modulation overview10:20 - Human evidence: oral Testolutin study (TT, LH/FSH ↑)11:02 - Human evidence: IM Testagen (2.5 mg x 10 days) results11:48 - 2022 combo study (4-peptide stack; free T ↑ ~54%)13:08 - Animal data: pituitary-independent thyroid restoration14:08 - Cell data: nuclear entry, histone/DNA binding14:34 - Outcomes summary: testosterone, LH/FSH, libido15:02 - Testagen vs TRT; stacking with Epitalon/Epithalamin16:01 - Safety profile: “no significant side effects” noted16:56 - Dosing protocol I recommend (2 mg/day, 10–60 days)17:24 - Full male-health stack ideas (Testagen + others)17:40 - Big-picture takeaway: who benefits most18:10 - Real-world reports, call for comments, and thanksI break down Testagen (a KEDG bioregulator) as a legit pathway to support testicular function, HPT axis “calibration,” and fertility—without typical TRT downsides. I walk through how it works at the epigenetic level (nuclear entry, histone/DNA interaction), human and animal evidence (oral Testolutin and injectable Testagen), thyroid and immune benefits, erectile/vascular support, and what I've seen in early adult men with low T. I also share my fertility plan, practical dosing (2 mg/day; 10–60 days), and how I'd pair Testagen with peptides like Epitalon, Libidon, Glandokort, and Superfort for broader rejuvenation. If you've used Testagen, drop your experience—wins or misses—so we can help the community learn what's working.

In this episode of The Pet Food Science Podcast Show, Micah Osborne, CEO of Stratum Nutrition, shares how eggshell membranes are being upcycled to support joint health in dogs. He breaks down their nutrient profile, sustainable sourcing, and research-backed benefits. Learn how this byproduct can elevate pet food formulation and support animal wellness. Listen now on all major platforms!"Eggshell membrane contains collagen, glucosamine, and hyaluronic acid, supporting joint and skin health in pets."Meet the guest: Micah Osborne is the CEO of Stratum Nutrition and a 20-year veteran of the nutraceutical industry. He leads innovations in upcycling eggshell byproducts into clinically backed pet food ingredients like NEM®. With deep knowledge from farm to supplement, he champions sustainable, traceable, and research-based solutions for companion animal nutrition.Liked this one? Don't stop now — Here's what we think you'll love!What will you learn:(00:00) Highlight(01:16) Introduction(05:58) Eggshell membrane composition(06:45) Separation process explained(09:19) Use in pet food(11:08) Dosing and efficacy(14:03) Clinical trial results(17:33) Final QuestionsThe Pet Food Science Podcast Show is trusted and supported by innovative companies like: Stratum* Kemin* Trouw Nutrition- Wilbur-Ellis Nutrition- Biorigin

What happens when you stop taking progesterone, even for just a few weeks? In this quick episode, I'm sharing my personal story of running out of progesterone, how my symptoms came rushing back, and why this hormone is so important for women in perimenopause. You'll learn why dosing and delivery methods matter, common signs of low progesterone, and how we help clients find a provider who actually understands women's hormones. I covered: My story of running out of progesterone and the symptoms that returned How progesterone is the first hormone to decline after 35 Common signs of low progesterone: mood swings, anxiety, poor sleep, heavy periods The pros and cons of oral, vaginal/rectal, and topical progesterone Why dosing matters (too low can trigger “estrogen kickback”) Why it's vital to find a hormone-savvy provider who listens and prescribes appropriately   WATCH ON YOUTUBE: https://youtu.be/CQ9YF9Go43k   Links Mentioned: Ona's Natural Progesterone Cream Moods, Emotions, and Aging: Hormones and the Mind-Body Connection by Phyllis Bronson Episode 32: Progesterone: The Miracle Hormone w/ Carol Petersen (Registered Pharmacist)   LOVE THE SHOW? Please subscribe, leave a 5-star rating, review, and share with other women, so they can get the support they need in perimenopause!    CONNECT WITH CLAUDIA:  Website YouTube Instagram Facebook Inquiries   FREE RESOURCES:  Peri-What?! The Must-Have Guide for Women 40+ Navigating Hormone Changes Perimenopause Daily Checklist HRT 3-Day Crash Course   GET SUPPORT:  Perimenopause Clarity Session The Perimenopause Method Program Perimenopause HRT Roadmap Course   PRODUCTS WE LOVE: Equip Prime Protein (Save 15% w/ code: healthcoachclaudia) Microbiome Labs Total Gut Restoration (Save 15% w/ code: claudia123) BodyHealth Reds & Greens Powders Symphony Natural Health Melatonin Glow Below Vaginal Estrogen or DHEA For more products we recommend, click HERE.

In today's VETgirl online veterinary continuing education podcast, we're diving into a recent study that may reshape how we manage feline infectious peritonitis (FIP), especially  around treatment dosing and duration. With growing success using antiviral therapy for this once considered “universally fatal” disease, we now have the opportunity to refine our protocols based on real-world outcomes. So today we are reviewing the exciting findings of this article by Kamiyoshi et al entitled “High-dose induction therapy and treatment termination criteria for feline infectious peritonitis with remdesivir, GS-441524 and adjunctive mefloquine: 46 cases (2023).”

What do Walt Disney, JFK and Elvis all have in common? Well, besides them all being deceased, of course… What if I added in the CIA, Paul McCartney, and LSD?! Would that narrow things down at all? No?!Well, all of these things listed are steeped deeply in conspiracy theories. Drinks w/ Ron joins the fun to surprise us with a bracket on some of the best, most well known & interesting concepts that many a mind have tried to decipher. All that, and much more!And if you enjoy what we are doing here at the Pit and would like to support us further, please check us out our patreon, where we have exclusive extended episodes! Today, we discuss the comedian Beetlejuice, the new Toxic Avenger movie, and the 35th anniversary of the cinematic debut of the Teenage Mutant Ninja Turtles!We also have some merch for sale up on our Etsy, as well as a limited run of embroidered beanies out now! Only a few left… Shoot us a DM on IG if you're interested.EtsyLinktreeYoutubesong at end of episode: Loopin Fields - Black Magic NoizeInstagram:@rjt243@ruining_your.childhood@feral_williams@aralessbmn@blackmagicnoize206@strangeloopanimation

  Welcome to the Prehospital Emergency Care Journal Podcast! In this PEC Podcast Deep Dive, Rebecca Cash and Maia Dorsett interview Dr. Tony Fernandez about his recent PEC paper comparing initial prehospital adenosine doses of 6 mg versus 12 mg for presumed SVT. We explore the study's origins, dataset design, and results—including the finding that starting with 12 mg was associated with higher rates of cardioversion and fewer redoses without an increase in complications. Along the way, we discuss the quirks of EMS data, why some “standard” practices exist without strong evidence, and how retrospective studies fit into the bigger picture of protocol change. For those whose interest in study methods was piqued, here's a great short primer on odds ratios versus relative risk: https://www.youtube.com/watch?v=dWtzaKYFg00&t=175s Featured Article Fernandez, A. R., Bourn, S. S., Duncan, D., Slovis, C. M., Crowe, R. P., Treichel, A., & Myers, J. B. (2025). Comparing Prehospital Adenosine Initial Dosing of 6 mg Versus 12 mg for Presumed Paroxysmal Supraventricular Tachycardia (PSVT). Prehospital Emergency Care, 1–6. https://doi.org/10.1080/10903127.2025.2504521

We discuss the observation that resolution of retinal fluid at one month in eyes with nAMD treated with aflibercept 8mg may herald longer duration treatment intervals at week 96 with Michael Stewart,, MD, Knights Templar Professor of Ophthalmology, Mayo Clinic, Jacksonville, Florida.

In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison, Dr. Angelina Davis, talks about the pharmacokinetics of antibiotics in patients with obesity. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40383125/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In a fascinating and insightful discussion, I sat down with Dr. Jon Brudvig, a medical scientist and expert in neuroscience and drug development. Together, we explored the science of aging, the critical role of cellular recycling, and the practical steps anyone can take to improve their healthspan. Jon Brudvig shared his journey from rare disease research to longevity science, offering actionable insights into how our daily choices impact the aging process. Such a good conversation, I have split it into two parts. What You'll Learn: The Cellular Foundation of Aging:Discover how Dr. Brudvig’s research into lysosomal storage diseases led him to understand the universal decline in cellular recycling (autophagy and lysosomal function) as a key driver of aging. Autophagy Explained:Learn why autophagy—the body’s process of breaking down and recycling damaged cellular components—is essential for health, and how modern lifestyles can disrupt this natural cycle. The Fundamentals of Longevity:Understand why exercise, diet, sleep, vitamin D, omega-3s, and real-life social connections are the true building blocks of a long and healthy life. Mouse Models and Human Longevity:Gain perspective on the limitations of animal studies in longevity research, and why findings in mice don’t always translate directly to humans. The mTOR Pathway and Protein Intake:Explore the debate around the mTOR pathway, protein consumption, and how balancing periods of growth and rest may be the key to optimal aging. Healthspan vs. Lifespan:Reflect on the difference between living longer and living better, and why increasing your years of good health (healthspan) is a more realistic and valuable goal than chasing extreme longevity. Key Takeaways: Aging is cellular: The decline in lysosomal and autophagy function is a core driver of aging and disease. Autophagy matters: Fasting, exercise, and periodic stressors help trigger the body’s natural recycling processes. Master the basics: Exercise, a balanced diet, quality sleep, and strong social ties are the most effective longevity interventions. Be cautious with quick fixes: Not all supplements or drugs that work in mice will work in humans—focus on proven fundamentals first. Balance is key: Intermittent activation of growth pathways (like mTOR) through meals and exercise, balanced with periods of rest, supports healthy aging. Protein quality counts: Mix your protein sources and prioritise whole foods for optimal health outcomes. Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ 00:53 Dr. Brudvig’s Background and PhD Focus01:22 Gene Therapy and Lysosomal Storage Diseases02:45 Connecting Rare Diseases to Aging03:10 Lysosomal Function and Aging03:40 Professional Work in Drug Development04:01 The Link Between Professional and Personal Interests04:22 The Role of Lysosomes in Autophagy04:40 What is Autophagy?04:54 Why Autophagy Matters for Cellular Health05:07 The Recycling Analogy: Cells as Master Recyclers05:26 Evolutionary Importance of Autophagy06:14 Autophagy, Fasting, and Modern Lifestyles07:07 The Impact of Modern Comfort on Health07:28 Social Media, Longevity, and Biohacks08:00 The Interventions Testing Program Explained08:42 Mouse Studies and Their Limitations09:32 The Importance of Fundamentals: Exercise, Diet, Sleep10:22 Omega-3s and Social Networks for Longevity11:00 The Hallmarks of Aging11:40 Homeostasis and the Aging Process12:20 Healthspan vs. Lifespan: Which Matters More?13:07 The Two Camps in Longevity Science13:51 Promising Interventions: SGLT2 Inhibitors and Rapamycin14:45 Rapamycin: Hype, Dosing, and Human Application15:53 mTOR Pathway, Protein Intake, and Longevity17:00 Balancing mTOR Activation and Autophagy18:00 Practical Protein Advice: Whey, Collagen, and Plant-Based Sources18:45 Final Thoughts: Eat Real Food and Mix Protein Sources See omnystudio.com/listener for privacy information.

Guest: Forrest Smith — serial founder bringing clinic-grade photobiomodulation to a safe, wearable form factor. Theme: Why dose and delivery matter more than raw wattage for red light therapy.Key takeawaysWavelengths that work: Deep red 660 nm (blood flow, NO release, shallow penetration) + 808 nm near-IR (deeper tissues/joints).Mechanisms: Hemoglobin photodissociates NO → vasodilation + better O₂ delivery; mitochondria's cytochrome c oxidase bottleneck relieved → higher ATP output; downstream: resilience to oxidative stress.Performance & recovery: Overnight reductions in CK and CRP let athletes train sooner; UFC PI and USA Weightlifting use cases mentioned.Brains & microvessels: Near-IR protocols tied to BDNF and microvascular improvements—an emerging Alzheimer's angle.Dosing > device hype: Class-1 lasers allow precise, reproducible dosing to deeper targets; panels/LEDs spread light too broadly and shift dose by distance (inverse-square).Safety & contraindications: Class-1 lasers are eye-safe in normal use; titanium implants OK (osseointegration may improve). Pregnancy and active cancer: regulatory contraindications despite encouraging early data.Personal protocol (example): 15 min over carotids + 15 min lower abdomen (gut) upon waking; higher-melanin skin generally needs longer time at same power.Resources & links (from interview)Kineon: kineon.io Chapter markers (approx.)00:00 Why red light now? 00:34 Mission: measurable QoL at scale 03:02 Risks of NSAIDs vs alternatives 03:34 660 nm + 808 nm explained 05:34 Newer NIR bands (905–1064 nm) 07:39 Penetration depth: red vs NIR 08:34 Photoacceptors & evolution (melanin) 10:28 Hemoglobin, NO, and O₂ delivery 12:02 Mitochondria & ATP bottleneck 14:06 Brain protection & TBI athletes 14:34 CK/CRP drops & faster training 15:55 Dosing by melanin level 17:49 Implants, pregnancy, cancer notes 21:22 Biphasic dose curve; laser classes 25:26 LEDs vs lasers; panels' dose drift 27:50 Strongest evidence areas (wound, knee OA) 29:33 Gut–brain, BDNF, microvasc/Alzheimer's 31:46 Forrest's daily protocol (neck + gut) 34:00 Systemic effects; fertilLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkinMimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611 Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Do you ever wonder how to safely use herbal medicine at home? Whether it's tinctures, teas, powders, or capsules, figuring out the right dose can feel a little overwhelming, especially if you're just starting out. In this week's Pantry Chat, I'm joined by Dr. Patrick Jones from HomegrownHerbalist.net to break it all down in a simple, practical way.We're covering:

In this episode of the PFC Podcast, Dennis and Kevin dive deep into the complexities of ketamine, exploring its pharmacodynamics, pharmacokinetics, and practical applications in emergency medicine. They discuss the drug's disassociative properties, its analgesic effects, and the importance of individualized dosing based on patient physiology. The conversation also touches on the risks of catecholamine depletion and the management of side effects, particularly in trauma patients. Throughout the discussion, Kevin shares valuable insights and practical advice for medics and healthcare professionals using ketamine in real-life scenarios.TakeawaysKetamine is an NMDA receptor antagonist with various effects on the body.It can cause profound analgesia and disassociation at different doses.S-ketamine is preferred for its more intense analgesic effects and quicker recovery.Dosing should be individualized based on patient condition and physiology.Ketamine can lead to catecholamine depletion, especially in trauma patients.Smaller doses are safer for patients with compromised vital signs.Analgesic effects can be achieved without full disassociation at lower doses.Managing side effects is crucial, especially in the 'party zone' of ketamine use.Always have a plan for potential complications when using ketamine.Refer to clinical practice guidelines (CPGs) for best practices.Chapters00:00 Understanding Ketamine: Basics and Mechanisms09:17 Pharmacokinetics of Ketamine: How It Works15:58 Dosing Ketamine: Individualized Approaches25:23 Analgesic Properties of Ketamine: Beyond Disassociation31:39 Managing Side Effects: The Party Zone and Hallucinations39:19 Catecholamine Depletion: Risks and Considerations43:05 Practical Advice for Medics: Using Ketamine SafelyFor more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care

Melatonin is often marketed as a simple sleep aid—but that's just the tip of the iceberg. In this episode of Integrative You Radio, Dr. Nick and Dr. Nicole break down the lesser-known but powerful role melatonin plays in detoxifying the brain and supporting neurological health. They explore how chronic stress, poor sleep habits, and lifestyle choices interfere with melatonin production—and how, when properly supported under physician guidance, melatonin can become a key ally in brain detox, gut-brain balance, and regenerative health. Whether you're battling insomnia, burnout, or brain fog, this episode offers eye-opening insights into a natural tool you may be overlooking.

Host Dr. Shawn McNeil is joined by Dr. Robert Sherrick to discuss his new article Relationship Between Methadone Induction Dosing and Retention in Treatment in Opioid Treatment Programs featured in the July/August issue of the Journal of Addiction Medicine.   Robert Sherrick, MD, DFASAM, is chief science officer for Community Medical Services, a company that serves patients through over 70 Opioid Treatment Programs in 12 states. He also has experience working at an inpatient addiction treatment facility, Pathways Treatment Center, treating all forms of substance use disorders and dual diagnosis patients.   Dr. Sherrick has been providing medication treatment for opioid use disorder since 2003, initially in an office setting using buprenorphine and subsequently with methadone in Opioid Treatment Programs. He established a state-wide buprenorphine treatment program for VA Montana with extensive use of telemedicine. He is board certified in internal medicine and addiction medicine through the American Board of Preventive Medicine. He is past president of the Northwest Chapter of the American Society of Addiction Medicine (ASAM). - Article: Relationship Between Methadone Induction Dosing and Retention in Treatment in Opioid Treatment Programs

The globalist-captured RDA recommends a milligram or less of iodine a day. The correct dose is 25 to several hundred milligrams daily.Support the show

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Show notes at pharmacyjoe.com/episode1054. In this episode, I'll discuss the optimal dosing regimen for meropenem and piperacillin/tazobactam in critically ill patients receiving continuous renal replacement therapy. The post 1054: What is the optimal meropenem and piperacillin/tazobactam dosing regimen for critically ill patients receiving continuous renal replacement therapy? appeared first on Pharmacy Joe.

Malignant Hematology Updates: Venetoclax dosing strategies continue to evolve HMA/Ven + IDH1/2 inhibitors: https://doi.org/10.1200/JCO-25-00640 HMA/Ven + revumenib: https://doi.org/10.1200/JCO-25-00914 Venetoclax + CPX-351: https://doi.org/10.1002/ajh.27723 APOLLO: https://doi.org/10.1200/JCO-25-00535 Iland APOLLO editorial: https://doi.org/10.1200/JCO-25-01496 ctDNA assessment vs. PET in Large B-Cell Lymphoma: https://doi.org/10.1200/JCO-25-01534

Dosing ECP for lung transplant rejection by TRANSFUSION's Monthly Podcast

What was something on your childhood wishlist that you're still kind of mad that you never got?Calculating potency isn't just math—it's the fundamental skill that transforms your cannabis kitchen from a guessing game into a precise culinary art. Whether you've ever found yourself unexpectedly bonding with your couch for six hours after a miscalculated brownie or thrown away gifted edibles because you had no idea how strong they were, this episode solves the dosing dilemma once and for all.I break down the seemingly complex world of THC calculations into a straightforward formula anyone can master, walking you through real examples that demonstrate exactly how to determine what's in each serving of your homemade treats. You'll discover why even experienced cannabis consumers sometimes need just a fraction of a gram to create perfectly dosed edibles, potentially saving you significant money while delivering consistently reliable experiences. Grab your Edible Dosing Cheat Sheet over at the website. By the end, you'll understand why knowing your numbers isn't about taking the fun out of edibles—it's about ensuring every experience is the right kind of fun.Continue the conversation and start connecting—head to JoinBiteMe.com right now. You'll find a private community of cannabis growers, makers and lovers who are just as obsessed or curious as you are.Support the show Visit the website for full show notes, free dosing calculator, recipes and more.

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn **American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support!

Host Hiwa Alaghebandian is back with potentially the giggliest episode yet. It's the August Hot or Not, and the trends we're getting into this month are Black Seed Oil, MACRO-dosing Creatine, and the Artists Way.If you've been seeing these three trends popping off all over social media and wondering if they're worth checking out, tune in to hear about the science & Hiwa's personal experiences.As always, if you enjoy this episode, please make sure you are subscribed to the show to hear more, leave a 5-star review telling us what you liked about it, and please share with your community who you think would benefit from the episode.If you have any questions you want answered on the podcast, submit them to theblushpod@gmail.com or LEAVE A VOICEMAIL. You can also submit anonymously here.Follow The Show:follow Hiwa on Instagramfollow Hiwa on TikTok

In this episode of Dog Cancer Answers, Dr. Robert Silver shares advanced insights on how medicinal mushrooms can support dogs with cancer. From beta glucan dosing to choosing the right mushrooms, Dr. Silver offers practical tips for pet parents. Learn about mushrooms like turkey tail, reishi, and maitake, their effects on cancer and immunity, and how to safely introduce them to your dog's regimen. Key highlights include: • Beta glucan dosages for mild, moderate, and severe conditions. • The importance of using standardized mushroom extracts. • How medicinal mushrooms train the immune system over time. • Safety tips, potential side effects, and starting doses. Your Voice Matters! If you have a question for our team, or if you want to share your own hopeful dog cancer story, we want to hear from you! Go to https://www.dogcancer.com/ask to submit your question or story, or call our Listener Line at +1 808-868-3200 to leave a question. Related Videos: https://www.youtube.com/watch?v=iAgObIOhEMg https://www.youtube.com/watch?v=y-eGlk1KhUg Related Links: Our article on Medicinal Mushrooms: https://www.dogcancer.com/articles/supplements/medicinal-mushrooms-for-dogs/ Real Mushrooms: https://www.realmushrooms.com/ Chapters: 00:00 – Introduction 00:15 – Why Mushrooms Are a Lifestyle Supplement 00:30 – Beta Glucans: The Key to Mushroom Dosing 02:00 – Dosage Tiers: Wellness, Moderate, and Severe Conditions 03:30 – Safe Dosing: Start Low, Go Slow 06:00 – The Science of Beta Glucans and Immune System Activation 10:00 – Mushrooms as Long-Term Immune Trainers 12:00 – Short-Term vs. Long-Term Effects of Medicinal Mushrooms 13:15 – Multi-Mushroom Formulas: The Benefits of Blends 16:00 – Spotlight on Chaga and Its Unique Properties 18:30 – Recent Turkey Tail Study: What the Research Says 24:00 – Real Mushrooms and Standardized Extracts 26:00 – Final Tips on Dosing and Safety 27:00 – Closing Thoughts and Dr. Silver's Insights Get to know Dr. Robert Silver: https://www.dogcancer.com/people/robert-silver-dvm/ For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Steroid Synergy, Rate My Physique, TRT Dosing Frequency, Performance Cycle - BSG Coaching QA Skip Hill, Andrew Berry, Scott McNally 0:00 teaser 0:45 Intro and advertisers 1:45 Synergistic Stacks 6:00 Uncommon Synergistic Stacks 13:00 SLU-PP-332 Variability In Results and Dosing 17:15 Rate My Physique 1 24:00 Rate My Physique 2 30:00 Wanting to increase free test 48:00 Test Cyp or Test E dosing frequency for TRT 52:45 Performance Cycle For Older Guy 1:01:10 Skip's favorite meal post contest?

​ @NickWalker39 Gets Real About Training, Coming Back, GLP Meds + Why He Loves Disney Movies

Today's episode is going to be a bit of a deep dive into something that comes up so often in coaching conversations, in my DMs, and honestly in my own personal T1D journey—and that is: all the sneaky little things that might be sabotaging your Time in Range…without you even realizing it. If you've been working really hard on your diabetes management but your CGM is still looking like a rollercoaster…or you just feel stuck and frustrated…this one's for you. So grab your coffee, your CGM graph, your notebook, whatever you need, and let's rise. Quick Takeaways:Understanding insulin: Dosing beyond carbs, adjusting ratios, and the importance of timing How to take ownership of your T1D and get off the BG roller coaster The unexpected and most influential factors sabotaging your TIR: Mindset, sleep + recognizing your patters Timestamps:[02:02] Understanding insulin dosing beyond carbs [05:06] Importance of adjusting your rates + ratios  [07:05] Micro decisions and their ripple effects[12:50] “All roads lead back to mindset”[13:13] Taking ownership of your T1D management [15:13] Insulin timing (a game changer) [18:33] Addressing insulin resistance [20:46] How sleep impacts blood sugar stability [21:36] Recognizing your patterns What to do now: Follow me @lauren_bongiorno and @riselyhealth on Instagram to stay in the loop when new episodes drop.Our signature Decide and Conquer Group Coaching Program is officially expanding to include 12 months of support for the first time ever! That's 3 months of transformation + 9 months of continued coaching, growth, and community. Doors for the September round are open now, and early bird pricing runs through July 31st.

Drs. David Andes and Isabel Spriet join Dr. Jeannette Bouchard to discuss all of the top questions our audience had on fluconazole dosing. Who needs a load? How much fluconazole is too much fluconazole? And what did one of our experts do when they were asked about dosing fluconazole in a dolphin? Listen in to find out! Listen to Breakpoints on iTunes, Overcast, Spotify, Listen Notes, Player FM, Pocket Casts, TuneIn, Blubrry, RadioPublic, or by using our RSS feed: https://sidp.pinecast.co/. Visit our website! https://breakpoints-sidp.org/ References: Fluconazole PK Variability in Critically Ill: DOI 10.3390/microorganisms9102068 DALI Antifungal Follow-up: DOI 10.1186/s13054-015-0758-3

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Donanemab's New Dosing Regimen: Lowering ARIA Risk in Alzheimer's Care" John Sims, MD, head of medical development for donanemab at Eli Lilly and Company, joins NeurologyLive to discuss the recently updated label for donanemab (Kisulna), an anti-amyloid Alzheimer disease (AD) therapy. Sims breaks down the key safety data from the TRAILBLAZER-ALZ-6 study (NCT05738486) that led to a newly approved titration-based dosing regimen aimed at minimizing ARIA risk. He outlines considerations for clinicians treating patients with early-stage AD, including genotype-based stratification, ARIA severity patterns, and implications for prescribing and patient counseling. Furthermore, Sims also shares takeaways about donanemab's clinical impact and how the results may shape the future of anti-amyloid therapy development and AD care. Looking for more dementia and Alzheimer disease discussion? Check out the NeurologyLive® Dementia and Alzheimer disease clinical focus page. Episode Breakdown: 1:00 – Overview of the new donanemab dosing regimen and its goal to reduce ARIA risk 2:30 – Rationale behind the four different dosing strategies tested in Trailblazer-ALZ-6 6:00 – What clinicians should know about patient risk and genotype testing 8:00 – Neurology News Minute 10:10 – Clinical implications of the updated label, including risk-benefit conversations 13:45 – Surprising results from the trial, particularly for APOE4 homozygous patients The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Orexin-Targeting Agent TAK-861 Meets All End Points in Phase 3 FirstLight and RadiantLight Studies FDA Shuts Down Sarepta's Distribution of Gene Therapy Elevidys Following Patient Deaths AD109 Meets End Points in Phase 3 LunAIRo Trial, Eyeing FDA Submission for Obstructive Sleep Apnea Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Hey all you gardeners! Welcome back to the show, we're here to share some of the best growing tips, practices, genetics information and just about everything needed to get your garden delivering its best buds.  Before the guys kick off their discussion, they get normal - Earl is puffin on some OGKush, WM is toking on Blue Zushi and @Terp_Fi3nd is seshing on his Mecha-Godzilla. From there they get right to business talking about effective ways to grow your plants while cutting your costs.  They talk about where the money needs to be spent and where you can save and adjust your spending, to create a set-up that is perfect for your desired results and the level of growing you plan to take on. Mr Weedman got a special delivery - a THC infused mocktail from Mrs Weedman midway through the show...stick around to see him totally zooted.  Dosing, you know - it's a thing, and she got it ALL wrong! Haha. Thanks for listening and as always, hit us up...IG: @terp_fi3nd  ---IG: @earl217 and @iamtheregalbeagleEmail: ThatRegalBegal@gmail.com---Twitter: @weedman420podYouTube: Weedman420 ChroniclesEmail: weedman420chronicles@gmail.com---Swag & Shop: https://eightdecades.comIG: @eightdecadesEmail: eightdecadesinfo@gmail.com---#High #Cannabis #StomptheStigma #FreethePlant #CannabisEducation  #CannabisResearch #Weed #Marijuana #LegalizeIt #CannabisNews #CBD #Terpenes  #CannabisPodcast #Podcast #eightdecades #Homegrow #Cultivation #BigEarl #Weedman420Chronicles #GrowHour #seeds #genetics #nutrients #IPM #Burpinthebag #LED #Lights #Atmosphere #TheRegalBegalBeanCo #Autoflower #autos #regs #photos #feminized #terps #plantmedicine #holistichealing #holistic  #seedbreeder #seedbank #beans #forage #chemisty #science #plants #hash #collab #flushCOPYRIGHT 2021 Weedman420Chronicles© Suggestions? Questions? Chat with us here.Support the show

The Peptique is LIVE! Go to https://thepeptique.com/ to get all your research peptides .As a loyal listener use the discount code VIP10 to get 10% off our entire line of products.Have questions? Feel free to reach out to me: tarawest@westwellnessatx.comWant to get started the right way, but don't know where to start. Email me tarawest@westwellnessatx.com to set up a 30 minute $100 session to get your personalized protocol. A special discount on your first order will be included. These spots fill up fast so schedule today!Follow me on instagram @westwellnessatx, @thepeptiqueIn this episode, I'm breaking down some of the biggest mistakes people make when getting started with peptides. Honestly, it can feel like the wild west out there—so much info, so many opinions, and not a lot of clarity. I've been in this space for a while now, and I've definitely learned a lot through trial and error. That's why I always tell people: do your research before jumping into any peptide protocol.One of the most important things I've found is that you have to know your goal before choosing a peptide. Are you trying to lose fat? Sleep better? Boost your focus? Having a clear goal makes it so much easier to pick the right peptide and get results that actually match what you're aiming for.I also talk about stacking—what works, what doesn't, and why randomly combining peptides without understanding how they work can totally backfire. I've seen it happen. Dosing is another big one. More isn't always better, and starting too high or too low can lead to disappointment—or side effects.At the end of the day, peptides are powerful tools, but they're not magic. They work best when you've already got your basics dialed in—nutrition, sleep, stress, recovery. This episode is all about helping you lay that foundation so you can actually get the most out of your peptide journey.

Welcome back to the Superhumanize Podcast. Today, we step into the radiant realm of healing, where ancient light meets modern science. My guest is Forrest Smith, a visionary at the intersection of wellness innovation and technology.As the founder of Kineon Labs and a former extreme athlete, Forrest brings decades of insight, both as a high-performing human and as a pioneering entrepreneur. His journey spans continents, from the rugby fields of South China to the tech corridors of North America. Along the way, he has built and sold multiple companies, delved deep into Chinese medicine and philosophy, and emerged with a powerful mission: to make cutting-edge red light therapy accessible, effective, and rooted in science.In this conversation, we explore what makes red light such potent allies for recovery, inflammation, performance, and even emotional well-being. We discuss photobiomodulation, how light interacts with our tissues at the molecular level, and why precise dosing truly matters. We also touch on the exciting future of light therapy for brain health, mood support, and energy optimization.Whether you are curious about pain management without pharmaceuticals, or interested in how light can nourish and heal the body, this episode will light the path.Episode highlights:02:00 – Forrest's journey from China-based tech entrepreneur and extreme athlete to mission-driven wellness innovator.04:00 – The founding vision of Kineon Labs: making high-quality red light and laser therapy devices accessible for home use.05:00 – Explanation of red light therapy and photobiomodulation—how light interacts with the body at a molecular level.07:00 – Why precise dosing matters: understanding the biphasic dose curve and photon absorption.09:00 – The role of nitric oxide and hemoglobin in increasing oxygen delivery and blood flow through light exposure.10:30 – How light affects mitochondrial function, oxidative stress, and inflammation on a cellular level.13:00 – Use of red light therapy in stroke recovery: extending the life of cells deprived of oxygen.14:00 – Designing devices backwards from desired biological outcomes instead of product features.17:00 – Why lasers outperform LEDs for dosing depth and precision.19:30 – Real-world outcomes from Kineon's Move+ device: high performance athletes, military, and aging populations.21:00 – Sustainable pain relief and mobility improvements for osteoarthritis and chronic injuries.24:00 – Long-term cardiovascular effects of untreated joint injuries—and how light therapy reverses them.27:00 – The power of stacking light therapy with stem cells, PRP, and shockwave treatments.31:00 – Protocols for joint pain and recovery: knees, backs, and sprains.39:00 – Forrest's favorite protocol: “Proximal Priority Therapy” for systemic inflammation and mood enhancement.41:00 – Transcranial light therapy and its promise for brain health, neurotransmitter balance, and immune resilience.44:00 – Future innovations: EEG and vagus nerve stimulation to support PTSD and autonomic regulation.50:00 – What's next: real-time brain energy mapping with single photon avalanche diodes.51:00 – Where to find Kineon products and community resources.Resources mentioned:Kineon Labs website – https://kineon.ioMove+ wearable...

BIO: Andy Sparks, PhD, was an academic in the UK for ~25 years and is now the Research Innovations Manager for Maurten AB, Sweden, and an Honorary Visiting Research Fellow at Liverpool John Moores University, UK. His research focuses on nutritional interventions to enhance sports performance, particularly the use of sodium bicarbonate. He has published extensively on a range of topics in exercise physiology and sports nutrition, with a particular interest in endurance cycling and running performance.Dr. Andy Sparks shares his expertise on sodium bicarbonate as an overlooked yet highly effective ergogenic aid for sports performance, with a particular focus on recent advances in delivery methods that minimize gastrointestinal distress. He explains the science behind bicarbonate supplementation and reveals why this supplement deserves more attention from athletes across multiple sports.Key Points!• Sodium bicarbonate is recognized as an A-list evidence-based supplement by the Australian Institute of Sport• Traditional delivery methods caused GI distress, giving the supplement a negative reputation despite its effectiveness• Works as an extracellular buffer that helps manage hydrogen ions during high-intensity exercise• May also reduce pain perception during exercise, explaining benefits in longer-duration events• Effective for high-intensity activities (400m-3000m races), intermittent sports, and even endurance events• Dosing varies widely (0.1-0.3g/kg bodyweight) with significant inter-individual response variability• Peak blood bicarbonate levels occur between 15-90 minutes post-ingestion, depending on delivery method• The Maurten bicarb system combines mini-tablets with a carbohydrate hydrogel to maximize effectiveness while minimizing GI issues• Safety concerns relate primarily to sodium load rather than bicarbonate itself• Particularly beneficial for race strategies with high-intensity starts followed by sustained effortsThe Maurten bicarb system is available online at maurten.com, with region-specific sites including a US option.

What if an anesthetic known for dental procedures could have a powerful effect on pain, inflammation, and nervous system regulation? Far beyond a numbing agent, Procaine is now being used as a powerful tool to reset the autonomic nervous system and treat chronic pain and stress at a cellular level.Joining me today is Lexi Yoo, a double board-certified Nurse Practitioner, IFM Certified Practitioner, and the founder of Yoo Direct Health. Learn more: @lexiyooNPYDH Training Academy: https://ydhacademy.com/In this conversation, we explore: • How Procaine IV works beyond anesthesia to influence the nervous, immune, and inflammatory systems • Why it may be one of the best-kept secrets for patients dealing with chronic stress, autoimmune issues, and lingering trauma • What the clinical research tells us after 20+ years of use in Europe and integrative clinics worldwide • And how to implement Procaine safely and effectively in modern clinical practice.Catch me at: Instagram: @doctorjones_doctorjones Become a patient: https://enovativewellness.com/ 

Text us a pool question!It's Floc It Friday, and Rudy's bringing the fire—along with borates, polyquats, and the brutal truth about mustard algae. In what might be our most packed episode to date, Rudy Stankowitz dives headfirst into the evolving mustard algae crisis in 2025—why your go-to treatment (sodium bromide) is now banned, how diatoms are getting smarter, and what you need to do to fight back.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Lawsuit filed against RFK Jr over vaccine policy changes; oral on-demand treatment approved for HAE; OTC cuffless blood pressure monitor gets greenlit; dosing schedule update for Alzheimer treatment; REMS requirement removed for endothelin receptor antagonist meds.

In this episode, Bernie and Anthony talk about some BIG changes in cytarabine dosing in AML consolidation after a recent practice changing article. Will this change your practice? Hunault, et al. NEJM. 2025.https://evidence.nejm.org/doi/full/10.1056/EVIDoa2400326

How tightly should you stick to a GA therapy's label? Which complement inhibitor do you pick and why? And which candidates are best suited for treatment? In part 1 of this 2-part series, moderator Judy Kim, MD, and panelists Sunir Garg, MD; Deepak Sambhara, MD, and Rishi Singh, MD, explore these questions in a brief (but enlightening) discussion. 

Navigating the complex landscape of patient safety requires vigilance, knowledge, and adaptability. Today's episode takes us on a journey through two critical safety concerns that exemplify the challenges anesthesiologists face in diverse clinical settings.We begin with an eye-opening exploration of cosmetic surgery safety in Colombia, which has emerged as a top global destination for aesthetic procedures. Despite performing nearly 500,000 cosmetic surgeries annually, Colombia faces alarming safety statistics—mortality rates potentially ten times higher than global averages for anesthesia-related deaths. This stark disparity highlights how regulatory gaps, substandard facilities, and inadequate patient selection can create perfect storms for adverse outcomes. The discussion illuminates how anesthesiologists can serve as safety champions by implementing rigorous standards and protocols.The conversation then pivots to a surprisingly common yet overlooked danger in pediatric anesthesia: the administration of oxymetazoline. What seems like a routine medication becomes hazardous when delivery systems designed for upright, conscious patients are used on supine, anesthetized children. Through practical demonstrations and creative problem-solving, we uncover how simple modifications to delivery methods—specifically using atomizers with precisely filled syringes—can prevent potentially dangerous overdoses and create standardized, position-independent dosing.Both topics underscore a central theme: anesthesia safety demands thoughtful adaptation of standards to fit unique circumstances. Whether dealing with international variations in practice or the specialized needs of pediatric patients, the commitment to "no one shall be harmed by anesthesia care" requires constant vigilance and innovation. We'd love to hear your experiences with similar challenges—have you encountered safety variations in different practice settings, or developed creative solutions to common problems? Visit APSF.org to explore our resources and join the conversation about advancing anesthesia patient safety worldwide.For show notes & transcript, visit our episode page at apsf.org: https://www.apsf.org/podcast/261-patient-safety-challenges-from-global-cosmetic-tourism-to-pediatric-medication-dosing/© 2025, The Anesthesia Patient Safety Foundation

If you're tired, wired, and in pain—this one's for you. Insomnia, stress, and chronic discomfort often show up together, and we tend to treat them like separate problems. But what if they all stem from something simple… and fixable?Lyndsay Soprano talks with Natalie Jurado, founder of Rooted In, about the quiet power of magnesium. Not the kind in chalky pills or powders that mess with your gut—but in a cream your body can actually absorb. Natalie shares how magnesium supports everything from sleep and anxiety to inflammation, energy, blood pressure, and even mood swings.They dig into how magnesium deficiency flies under the radar, why it's often misdiagnosed, and how most of us—kids included—aren't getting enough. From ADHD to weight loss to workout recovery, magnesium plays a starring role in our well-being. And the truth is, food isn't always enough.This conversation is equal parts science and real talk. It's about understanding your body, getting ahead of burnout, and giving your nervous system the support it's been quietly begging for.Tune in if you've tried everything for your pain, sleep, or stress—and nothing's worked. This might be the missing piece.Find Natalie Jurado Online Here:Website: berootedin.comInstagram: @berootedinFacebook: Rooted InLinkedIn: Natalie JuradoFind The Pain Game Podcast Online Here:Website: thepaingamepodcast.comInstagram: @thepaingamepodcastFacebook: The Pain Game PodcastLinkedIn: Lyndsay SopranoYouTube: The Pain Game PodcastEpisode Highlights:(00:00) Introduction to Chronic Pain and Healing(01:16) The Connection Between Insomnia, Pain, and Stress(02:41) Exploring Magnesium for Relief(03:38) Understanding Magnesium: The Essential Mineral(07:13) Personal Journeys with Insomnia and Anxiety(12:24) Creating Effective Magnesium Products(15:37) Benefits of Magnesium for Health(19:12) Magnesium and Cholesterol Management(20:21) Safe Usage and Dosing of Magnesium Cream(27:01) Magnesium's Role in Diabetes and Blood Sugar(28:05) Magnesium for Pain Relief(30:31) Final Thoughts and Encouragement

EP. 212: Today I'm joined by Dr. Spencer Nadolsky, obesity specialist, Lipidologist, and founder of Vineyard, a cutting-edge direct care platform. We're diving deep into the conversation you've been asking for: the real story behind GLP-1s, obesity as a chronic disease, and why treating it goes far beyond weight loss. We break down everything from proper dosing, common side effects, and the dangers of vanity prescribing to the systemic issues with telemedicine and PBMs. Dr. Nadolsky and I also discuss strength training, preserving muscle mass, and how GLP-1s may support metabolic and cardiovascular health beyond their FDA indications. This episode cuts through the noise and misinformation. If you care about metabolic health, this one's essential. Topics Discussed:  What are the real benefits of GLP-1 medications beyond weight loss? Is obesity truly a chronic disease, and how should it be treated? What are the risks of GLP-1 vanity dosing and fast titration? How do GLP-1s impact muscle mass and metabolic health? Why are telemedicine and PBMs problematic for obesity treatment? Sponsored By: Maui Nui Venison | Head to mauinuivenison.com/DRTYNA to secure your access now.  LMNT | Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15% Liver Love | Go to https://store.drtyna.com/products/liverlove Use code LIVER20 for 20% off On This Episode We Cover:  00:00:00 – Introduction  00:02:48 – GLP-1 Dosing  00:06:35 – Side Effects of Vanity Dosing 00:08:51 – Reducing GLP-1 Dosing 00:12:27 – Med Spas & Telemedicine Risks 00:14:20 – Slow Titration for Better Tolerance 00:18:44 – Pharma Profits & Overdosing 00:20:49 – Obesity Treatment Pre & Post GLP-1s 00:27:58 – Obesity Is a Chronic Disease 00:32:45 – Defining obesity  00:36:16 – The Role of Genetics in Obesity 00:38:59 – Lifestyle Factors Beyond Genetics 00:40:46 – Insurance Barriers & PBM Costs 00:44:37 – Anti-GLP-1 Bias in Healthcare 00:46:22 – Why Strength Training Matters 00:51:39 – New Doctors & Role of AI 00:53:38 – Protecting Muscle on GLP-1s 00:58:55 – No Shortcuts to Health 01:02:01 – The Vineyard Show Links: Glp-1s Can Help Employers Lower Medical Costs In 2 Years, New Study Finds Further Listening GLP1 Uncovered FREE 4 Part Video Series  Ozempic Done Right Playlist EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knap Check Out Dr. Spencer Vineyard Instagram Website Podcast Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Listen to the full episode here: https://podcasts.apple.com/us/podcast/habits-and-hustle/id1451897026?i=1000674829479  Ever wondered if you're truly maximizing the benefits of your GLP-1 medication? In this Fitness Friday episode on the Habits and Hustle podcast, I talk with Dr. Tyna Moore to discuss getting the most out of GLP-1s like Ozempic - especially for women approaching or experiencing menopause. We dive into how to determine the right GLP-1 dosage for your body, why strength training is non-negotiable when taking these medications the surprising connections between hormones, pain management, and joint health.  Dr. Tyna is an expert in holistic regenerative medicine and resilient health with nearly three decades of experience in the medical world. Dr. Tyna brings a unique perspective to building robust health foundations, having graduated from the National College of Natural Medicine and the University of Western States Chiropractic College. She is also a #1 Best Selling author, international speaker, and host of The Dr Tyna Show Podcast.  What we discuss: How to determine the right GLP-1 dosage for your body Why strength training is non-negotiable when taking these medications The surprising connections between hormones, pain management, and joint health How GLP-1s can help with addiction issues beyond just food cravings Thank you to our sponsor: AquaTru: Get 20% off any purifier at aquatru.com with code HUSTLE Therasage: Head over to therasage.com and use code Be Bold for 15% off  TruNiagen: Head over to truniagen.com and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. BiOptimizers: Want to try Magnesium Breakthrough? Go to https://bioptimizers.com/jennifercohen and use promo code JC10 at checkout to save 10% off your purchase. Timeline Nutrition: Get 10% off your first order at timeline.com/cohen Air Doctor: Go to airdoctorpro.com and use promo code HUSTLE for up to $300 off and a 3-year warranty on air purifiers.  Bio.me: Link to daily prebiotic fiber here, code Jennifer20 for 20% off.  Momentous: Shop this link and use code Jen for 20% off To learn more about Dr. Tyna Moore:  Ozempic Uncovered: https://www.drtyna.com/ozempicuncovered  Instagram: https://www.instagram.com/drtyna/ Youtube: https://youtube.com/@drtyna Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagements