Podcasts about Dosing

With so many supplements marketed to runners, it's easy to wonder what's actually worth taking. In this episode, we cut through the noise and focus on a few supplements that have strong research behind them—while emphasizing that no supplement can replace consistent training, good nutrition, quality sleep, and proper recovery.We break down the Three Cs: Carbohydrates, Creatine, and Caffeine.First, we discuss why many runners are underfueling and how carbohydrates play a critical role in performance, recovery, and endurance. Next, we explore creatine monohydrate, one of the most researched supplements available, and its benefits for strength, recovery, and overall health. Finally, we cover caffeine, including how it can improve performance, common dosing guidelines, and why personal tolerance matters.We also briefly touch on vitamin D, magnesium, omega-3s, and collagen, and discuss when they may be worth considering.In This Episode:Why supplements should never replace the fundamentalsHow carbohydrates support performance and recoveryThe benefits of creatine for runnersHow caffeine can enhance enduranceWhen other supplements may be helpfulAvoiding the optimization trap and keeping things simple03:53 The Three Cs 09:59 Fueling During Runs14:29 Carb Targets And Gut Training20:16 Women Over 40 And Carbs25:03 Adjusting Fuel To Effort28:31 Creatine Explained41:14 Monohydrate and Daily Dose43:25 Caffeine Performance Basics46:23 Dosing and GI Timing47:33 Metabolism and Jitters50:29 Sleep and Tolerance Tradeoffs54:12 Race Day Caffeine Rules56:54 Vitamin D Testing59:34 Magnesium for Cramps01:03:38 Omega 3 Benefits01:05:26 Collagen Versus ProteinGain access to my new secret podcast, Unbreakable: The Runner's Guide To Injury-Proofing Your Body After 40. Click here: https://www.realliferunners.com/secretJoin the Team! -->  https://www.realliferunners.com/team Thanks for Listening!!Be sure to hit FOLLOW on Apple Podcasts, Spotify, or your favorite podcast player Leave a review on Apple Podcasts. Your ratings and reviews really help and we read each one!Come find us on Instagram and say hi! Don't forget: The information on this website is not intended to treat or diagnose any medical condition or to provide medical advice. It is intended for general education in the areas of health and wellness. All information contained in this site is intended to be educational in nature. Nothing should be considered medical advice for your specific situation.

This episode discusses the urgency for pharmacists to transition from using Cockcroft-Gault eCrCL to non-race based estimated glomerular filtration rate (eGFR) to improve medication-related decision-making in persons with reduced kidney function.  Listeners will learn how to transition from C-G eCrCL to eGFR adjusted for body surface area to improve medication effectiveness and safety in persons with chronic kidney disease. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksTesamorelin is one of the few peptides I've seen actually move the needle on body composition. So I made a full masterclass on it.This is the user's guide as it stands in 2026. I cover what tesamorelin is, how it works, and the best practices I'd recommend for using it.We get into the growth hormone axis and why a GHRH is different from a GHRP. I break down the clinical data, the 15% visceral fat reduction, the liver fat numbers, and the cognition research almost nobody talks about.Then we get practical. Dosing, timing, fasted injections, and the cycling patterns I actually use. I share why I stay at one milligram instead of two and what the water retention tradeoff looks like at higher doses.I also cover stacking with testosterone and GLP-1s, reconstitution, injection technique, side effects, and the people who should skip this one entirely.I'm honest about the limits too. Some of this evidence is strong and some of it isn't. I tell you which is which.If you're thinking about tesamorelin or already using it, this is everything I'd want you to know.

Send us Fan MailDr. Ian Justl Ellis is the Founder, CEO, and Lead Physician at Voafit. He specializes in helping individuals achieve their optimal physique while maintaining balance in their family, work, and social lives. His approach focuses on creating sustainable, real-world nutrition and exercise habits that can be maintained long-term without obsessive or unhealthy behaviors.Dr. Ellis has spent much of his life addressing what he describes as the "appetite problem." As a teenager determined not to follow the path of out-of-shape adults around him, he immersed himself in athletics, amateur bodybuilding, professional dance, and became a certified personal trainer. Despite achieving the desired outward appearance, he found himself caught in cycles of restriction, bingeing, and frustration.During medical school, marriage, and raising children simultaneously, he experienced significant personal weight gain and burnout, finishing residency sixty pounds overweight. In 2022, he was introduced to GLP-1 weight management medications, which helped address persistent hunger for the first time. However, using them in standard recommended dosing approaches resulted in muscle loss, weakness, and poor nourishment.In response, Dr. Ellis developed a precision-based approach to GLP-1 therapy that combines strength training, protein-first nutrition, hydration, and individualized dosing strategies. He also incorporated advanced peptide therapies to support hormonal optimization, muscle retention, and recovery.Website: Voafit.comUse code FA FOR 40% OFF Athletic greens is a non-negotiable part of my daily routine. With 75 absorbable vitamins and minerals in just one scoop a day, I have increased my energy, improved my immune function and so much more. To get your own AG at 20% off go to www.athleticgreens.com/functionallyautoimmune Order now for a free vitamin D3/K2 supplement and 5 free travel packs!Support the show

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksTB-500 spends way too much time in BPC-157's shadow. I wanted to fix that.This is my full TB-500 masterclass. I go deep on what this peptide actually does, and why it works so differently than BPC even though we lump them together as the Wolverine stack.First I clear up the confusion between TB-500 and thymosin beta-4, because most people have no idea what they're actually buying. Then I break down the mechanism in plain language. Think of TB-500 as the foreman on a job site, moving the right materials to the right injury at the right time.I cover who it's for, who should skip it, and my full dosing tiers from general recovery up to severe injury. We get into cycling, reconstitution, injection technique, and how to stack it with BPC, GHK, and the growth hormone peptides.I also answer the big questions. Is it legal? Will it cause cancer? Will it touch your hormones? Does it grow hair?If you want more from me, get on the email list and check out the Axion Collective. Both links are in my bio.Enjoy this one. I love TB-500.

Most herbal dosing strategies fail during acute infections, not because the herbs are wrong, but because the dosage, frequency, and timing are wrong. In this video, Sajah Popham from the School of Evolutionary Herbalism walks you through the four biggest mistakes herbalists make when treating infections, and how to create protocols that lead to better outcomes. Here's what you'll learn: Why herbal dosing for acute infections is different from chronic care The four most common mistakes people make when taking herbs during illness Why low-dose strategies often fail in the treatment of acute infections Suggested dosage and frequency guidelines for acute herbal protocols Why herbs need time and consistency to build up and be effective How to think about various herb classes as part of your treatment protocol The importance of organ-system specificity and tissue state energetics Why herbs don't work the same way antibiotics do, and how to manage client expectations Treating lingering symptoms  Supportive lifestyle practices that improve recovery outcomes Warning signs that indicate it may be time to seek medical attention   If you want to dive even deeper into this kind of information, you might really like our FREE Vitalist Herbalism Mini-course.  Join the waitlist to get the FREE workshop when it starts on June 15, 2026: http://www.evolutionaryherbalism.com/vitalist-herbalism-mini-course/waitlist/   ———————————— CONNECT WITH SAJAH AND WHITNEY ———————————— To get free in depth mini-courses and videos, visit our blog at:  http://www.evolutionaryherbalism.com   Get daily inspiration and plant wisdom on our Facebook and Instagram channels: http://www.facebook.com/EvolutionaryHerbalism https://www.instagram.com/evolutionary_herbalism/   Be sure to subscribe to our YouTube Channel: https://www.youtube.com/channel/UCyP63opAmcpIAQg1M9ShNSQ   Get a free 5-week course when you buy a copy of the book, Evolutionary Herbalism: https://www.evolutionaryherbalism.com/evolutionary-herbalism-book/   Shop our herbal products:  https://naturasophiaspagyrics.com/   ———————————— ABOUT THE PLANT PATH ———————————— The Plant Path is a window into the world of herbal medicine. With perspectives gleaned from traditional Western herbalism, Ayurveda, Chinese Medicine, Alchemy, Medical Astrology, and traditional cultures from around the world, The Plant Path provides unique insights, skills and strategies for the practice of true holistic herbalism. From clinical to spiritual perspectives, we don't just focus on what herbs are "good for," but rather who they are as intelligent beings, and how we can work with them to heal us physically and consciously evolve.   ———————————— ABOUT SAJAH ———————————— Sajah Popham is the author of Evolutionary Herbalism and the founder of the School of Evolutionary Herbalism, where he trains herbalists in a holistic system of plant medicine that encompasses clinical Western herbalism, medical astrology, Ayurveda, and spagyric alchemy. His mission is to develop a comprehensive approach that balances the science and spirituality of plant medicine, focusing on using plants to heal and rejuvenate the body, clarify the mind, open the heart, and support the development of the soul. This is only achieved through understanding and working with the chemical, energetic, and spiritual properties of the plants. His teachings embody a heartfelt respect, honor and reverence for the vast intelligence of plants in a way that empowers us to look deeper into the nature of our medicines and ourselves. He lives on a homestead in the foothills of Mt. Baker Washington with his wife Whitney where he teaches, consults clients, and prepares spagyric herbal medicines.    ———————————— WANT TO FEATURE US ON YOUR PODCAST? ———————————— If you'd like to interview Sajah or Whitney to be on your podcast, click here to fill out an interview request form. If Whitney is facilitating an interview:   ———————————— ABOUT WHITNEY ———————————— Whitney Popham is an herbal practitioner and the co-founder of The School of Evolutionary Herbalism and Organic Unity. Her calling to plant medicine began from a deep passion for activism and a vision for creating healing and positive change in the world. She has devoted her life to that vision by being a humble vessel for the plants to touch people's lives and bring more healing and beauty into the world.   Through her own health challenges and struggles, she experienced the profound healing gifts of plant medicines and then committed her life to helping others reach vibrant levels of health. She specializes in digestive health in her clinical practice through working with herbal medicine, nutrition and lifestyle coaching. Her true gift is in listening to the plants through intuition and vision, which she uses to help her clients with healing on the emotional, psychological, spiritual, as well as physical levels of health.  

In today's podcast episode, I'm joined once again by thyroid expert and author Paul Robinson for a listener-led thyroid Q&A session. After our first thyroid conversation was so well received, I invited members from my Facebook community to submit their biggest thyroid-related questions, and we covered a wide range of topics surrounding hypothyroidism, Hashimoto's, T3 therapy, reverse T3, thyroid labs, symptoms, body temperature, hormone balance, and more. Some of the questions discussed in this episode include: • Is reverse T3 testing important? • How low is too low for TSH? • Why do some people with Hashimoto's struggle to convert T4 into T3? • What do high thyroglobulin and anti-thyroglobulin antibodies mean? • How can you support better T4 to T3 conversion? • Why do some people worsen on natural desiccated thyroid? • Can T3 dosing schedules change as healing occurs? • Can BHRT change thyroid medication needs? • Is there a connection between hypothyroidism, Hashimoto's, and migraines? • Can you still have hypothyroid symptoms with a “normal” body temperature? • What markers can help identify reverse T3 issues when testing is unavailable? • How can symptoms, pulse, blood pressure, and temperature help guide T3 dosing? This conversation is educational, nuanced, and filled with practical insights for those navigating thyroid symptoms and thyroid treatment. Paul Robinson is the author of: • The Thyroid Patient's Manual • Recovering with T3 • The CT3M Handbook Whether you are newly diagnosed, struggling despite “normal labs,” or wanting a deeper understanding of thyroid physiology and treatment approaches, I hope this conversation helps you feel more informed and empowered. Paul Robinson is a thyroid patient and thyroid patient advocate. Paul wrote 'The CT3M Handbook' as a companion book to 'Recovering with T3' to explain more about raising cortisol levels if needed. And Paul wrote his third book ‘The Thyroid Patient's Manual'. This book covers all types of thyroid medications (T4, T4/T3, NDT, and T3). His newest book "Articles on Hypothyroidism" combines the best of what Paul has discovered on his 35 year thyroid journey. Find out more about Paul here; https://paulrobinsonthyroid.com/ YouTube - @RecoveringwithT3 Instagram - / paulrobinsonthyroid Books; The Thyroid patients manual https://a.co/d/9VwgyLx The CT3M handbook https://a.co/d/iR5Zayv Recovering with T3 https://a.co/d/1035MD3

Please Note: This is a webinar recording, if you prefer to watch with video to see the slides they reference, this can be found on our Arthramid Equine YouTube Channel. Catch the replay of the recorded CE session from May 2026 on how 2.5% iPAAG (Arthramid) is used in equine joint disease, with a focus on dosing decisions and real-world case management. Dr. Jason Lowe (Chief Veterinary Officer, Contura Vet) opens with a refresher on what 2.5% iPAAG is and how it works as a mechano-modulating synovial implant, including the research underpinning its effect on the synovial membrane. He is joined by two clinicians sharing cases from everyday practice:Dr. Sean Allison, Cleveland Equine ClinicDr. Beau Whitaker, Salado Equine Medical CenterWhat 2.5% iPAAG is and how it targets the synovium to address synovitis and fibrosisThe research behind its effect on synovial membrane elasticityFindings from a retrospective review of Dr. Allison's own caseload (around 100 horses, 138 joints)Dosing rationale based on joint size and severity of diseaseCase-based discussion across the hip, shoulder, stifle, lower hock joints, and digital flexor tendon sheathUse in low-motion joints, post-surgical cases, and repeat or top-up dosingThe discussion moves from mechanism to the questions clinicians actually face: how much to use, how often, in which joint, and how 2.5% iPAAG fits alongside existing therapies and in more complex or non-responding cases.What the session covers:

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You do the work. You train, you sleep, you eat well, you manage stress. And yet your joints still ache, recovery takes longer, and something just feels harder than it used to.I sit down with David Watumull, co-founder and CEO of AX3, to talk about astaxanthin, a naturally occurring antioxidant he has spent his entire career studying, one that most people have never heard of despite having more than 4,000 peer-reviewed papers and 100 human clinical trials behind it.This is not a conversation about the latest wellness trend. It's a deep look at the science of oxidative stress, chronic inflammation, and what actually happens inside your cells when the damage accumulates faster than your body can repair it.What we explore:- Why astaxanthin is categorically different from vitamins C and E, and how it works at every layer of the cell without ever becoming pro-oxidant.- How chronic inflammation starts with oxidative stress upstream, and why blocking it at the source is safer than suppressing the immune response after the fact.- Why this ingredient was one of only five agents in a 20-year NIH-funded program to extend mammalian lifespan by over 10 percent while also showing health span benefits.- How astaxanthin protects joints, muscles, and mitochondrial energy production, and what the data on competitive cyclists actually demonstrates.- What to look for in a supplement, why bioavailability determines whether you absorb anything at all, and how to build astaxanthin into a foundational daily stack.Chapters: 00:00 Intro03:30 Why Astaxanthin Isn't Like Other Antioxidants07:14 The Algae Origins of Astaxanthin11:22 Salmon, the Food Chain, and Nature's Design15:00 From Pharma Research to Supplement18:21 The NIH Longevity Study Explained23:15 mTOR, FOXO3, and the Aging Pathways29:10 Safe Anti-Inflammatory for Joints and Athletes35:15 Brain Protection and the Blood-Brain Barrier38:02 Skin Health and Sun Damage from the Inside45:00 Redox Balance and Liver Protection48:35 Mitochondria, Energy, and Endurance Performance53:00 How to Stack Astaxanthin with Other Supplements57:10 Dosing, Bioavailability, and What Sets AX3 Apart01:07:00 Why David Watumull Went All-In on One IngredientAbout David Watumull:David Watumull is the co-founder and CEO of AX3, a supplement company built on more than two decades of astaxanthin research. He was introduced to the ingredient as a teenager working on algae ponds on the Big Island of Hawaii, and has spent his career advancing its science through pharmaceutical-grade manufacturing, NIH-funded longevity studies, and peer-reviewed cardiovascular research. His work sits at the intersection of rigorous science and practical supplementation, and it shows.Connect with David Watumull:Instagram: https://www.instagram.com/davewatumull–This episode is sponsored by:AX3: Visit ax3.life and use code GABBY for 20% OFF your first orderWebsite: https://www.ax3.lifeInstagram: https://www.instagram.com/ax3.life–The Gabby Reece ShowThis is where I have real conversations with the people I find most worth listening to: scientists, athletes, coaches, parents, and thinkers who are doing the hard work of building a life that holds up over time. No hacks. No quick fixes. Just honest, practical conversations about performance, longevity, relationships, and what it actually takes to show up well at every age.If you are here, you probably already know that health is not a destination. It is how you live. I am glad you are along for it.Connect with Gabby Reece:Instagram: https://www.instagram.com/gabbyreece/TikTok: https://www.tiktok.com/@gabbyreeceofficialWebsite: https://gabriellereece.comPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Hosts: Ed Jones (Owner of Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Impact of Tennessee Hemp Bill, Discussion of Polypharmacy & Deprescribing  with Dr. Curt Dearing [0:00:00] Ed's Media & Product Updates Preview of main topics: Upcoming Tennessee hemp bill and its negative impact on people using hemp for anxiety, pain, and insomnia. Dr. Curt Deering will discuss polypharmacy and deprescribing. Ed's recent appearances on multiple TV outlets (Fox Phoenix & LA, Be Well NY, CBS Detroit). Discussion of testing the AquaTru water filtration system at home as a potential recommendation (microplastics, partial fluoride removal). Mention that peptides are a growing topic; reference to Noel Lawson as go‑to for prescribed peptides [0:10:42]  Tennessee Hemp Bill & Hemp Industry Impact Introduces guest: Dwayne Madden, owner of Hemp House, as a respected local expert. As of July 1 in Tennessee: All Delta‑8 products will no longer be available for in‑state sale. Many THCA products and all vape products will be gone from shops. CBD and Delta‑9 edibles will have caps: Max 15 mg per serving. Max 300 mg per package. Dwayne notes: Heavy users (e.g., serious pain/conditions) will need to consume many servings to reach effective doses. Law doesn't limit how many packages a person can buy, so total milligrams aren't truly stopped—just made inconvenient. Dwayne explains regulatory control moved: From Tennessee Department of Agriculture (2017–2023) To the ABC (Alcoholic Beverage Commission) Board. Key impacts: All products must now go through distributors, similar to alcohol. Distributors collect taxes and sit between producers and retailers. Small operators like Dwayne cannot qualify for distributor licenses , so he must pay a distributor to move product from his own lab to his own stores. Ed frames this as “follow the money trail” and a way to crush competition. In Tennessee after July 1: No in‑state online hemp sales. Banned products (Delta‑8, etc.) not criminalized for possession or use, only for sale. Potential Workaround: Consumers can order from out‑of‑state websites (e.g., North Carolina), receive products in Tennessee Money leaves the local economy, hurting Tennessee businesses. Ed and Dwayne suggest alcohol industry is likely threatened because many people are reducing alcohol use by using hemp products instead  Dwayne notes: Alcohol sales have declined while hemp sales rose. Regulators appear to be protecting alcohol interests via hemp restrictions. [0:17:41] Federal Regulations & State Opt‑Outs Upcoming federal regulations in November: Expected to be similarly “ugly and nasty” for hemp nationwide. States will have an option to opt out of these federal hemp rules. Tennessee's stance: Governor has stated Tennessee will NOT opt out, so federal restrictions will apply here. Other states (e.g., North Carolina) might opt out, keeping their markets more open. Industry response: Advocacy groups Tennessee Growers Coalition and Hemp Law Group monitor legislation and organize pushback. Some supportive legislators exist, but political drive to reverse current law is limited. Dwayne and Ed distinguish: Reasonable regulation (ID checks, lab tests, dosage clarity, education) vs. A “wipeout/control/takeover” by shifting to ABC and forcing distributor reliance. Dwayne: Says credible local shops (Hemp House, Chattanooga peers like BeeGrity, Snapdragon, etc.) already follow high standards. States this law is not about safety but about control and revenue capture, and will hurt small farmers and businesses. [0:25:55] What Consumers Should Do Before Deadline Practical advice: Stock up now on products that will disappear: Delta‑8 gummies (popular for sleep, anxiety, pain). Other higher‑milligram THC/CBD edibles. Flower and vapes. Hemp House is running clearance sales to move remaining inventory. Dosing notes: Many people do well with ½ Delta‑8 gummy for sleep/anxiety/pain. Some need more or less; staff helps tailor doses for goals. Hemp House will close its North Shore/Tremont Street flagship store by July 1 due to expected sales hit. Remaining Hemp House locations: Ringgold Road (East Ridge) near Spring Creek. Ooltewah by Food City on Lee Highway. Hixson Pike near Workout Anytime and Publix. Broader impact: Other Chattanooga hemp businesses have large staffs (some near 100 employees) and will be heavily affected. The industry is described as grassroots, farmer‑driven, and passionately quality‑focused. [0:33:20] Polypharmacy & Deprescribing with Dr. Curt Dearing Ed introduces Dr. Curt Dearing, clinical pharmacist at Nutrition World (30+ years experience). Curt's background: Formerly fully conventional pharmacist; later “veil lifted” as he discovered green pharmacy (nutritional & botanical alternatives). Current mission: Community outreach to medical schools and residency programs Teach about nutritional and natural alternatives not covered in standard curriculums. Traditional training provides almost zero meaningful nutrition or green pharmacy education. Polypharmacy: use of 5 or more prescription medications. Curt notes: Majority of Americans 65+ meet this definition. Average American receives ~17 prescriptions per year (not all concurrent). Consequences: Increased ER visits due to drug side effects. Estimated ~250,000 deaths/year from drug‑induced causes. Curt's role: Specializes in deprescribing: safely reducing or eliminating unnecessary pharmaceuticals and replacing them with effective natural options when possible.  How Curt Works with Patients & Their Doctors Curt provides coaching, not independent prescribing. Creates detailed packets (10–18+ pages) explaining: Why certain drugs may no longer be needed. Evidence for natural alternatives (e.g., supplements, lifestyle changes). Encourages clients to take the packet to their doctor and have an informed discussion. Patients often fear how their doctors will react to attempts to deprescribe. Green Pharmacy Approach (as described by Dr. Curt Dearing) Using nutritional, botanical, and lifestyle-based therapies either instead of or alongside pharmaceuticals. Focusing on root causes and supporting the body's own healing mechanisms, not just pushing lab numbers in a certain direction. Why polypharmacy is a problem: Increases side effects, drug–drug interactions, and emergency room visits. Contributes to cognitive decline, gut problems, and overall worse health. Often leads to the “prescribing cascade”: Drug A causes side effects → a new drug is added for those side effects → more side effects → more drugs, and so on. How Dr. Curt Dearing uses green pharmacy to reduce polypharmacy: Curt creates a comprehensive list of all medications and supplements. Asks: “Why was this started?” and “Is it still needed?” Looks for: Drugs with no clear current indication. Drugs where a natural option can give similar or better benefit with fewer risks. Drugs that can be safely tapered or sometimes stopped outright (always in coordination with the prescriber). Identifies which meds are likely causing the most harm or least benefit. Some drugs require slow, structured tapering (e.g., sleep meds, acid blockers). Others may be candidates for direct discontinuation after medical agreement. Replacing or supporting with natural alternatives ( please note this is not medical advice, this is a discussion of personal examples in collaboration with medical oversight) Cholesterol: Instead of (or in place of some) statin use, Curt uses berberine and bergamot (Berbercol). In Ed's brother's case, his cholesterol numbers improved on green-pharmacy options, matching or exceeding statin outcomes without the same side‑effect burden. Pain & inflammation: Uses curcumin (for most people), and Boswellia when curcumin isn't enough. Gut/acid issues: Long-term proton pump inhibitor (PPI) use (e.g., omeprazole, lansoprazole) is flagged as harmful to gut microbiome and nutrient absorption. Curt builds step-down plans (tapering PPIs) while supporting the gut with natural measures instead of leaving people on a PPI for 30 years. Focus on side benefits, not side effects. Green pharmacy interventions are chosen because they: Address root causes (e.g., metabolic health, inflammation, gut integrity). Often have multiple positive effects (e.g., berberine helping blood sugar and lipids; curcumin helping joints and systemic inflammation). The aim is fewer total drugs, fewer side effects, better overall function. Clients are encouraged to work with their doctor, so deprescribing is: Planned, Monitored, and Integrated with their existing care. Curt and Ed both acknowledge there are situations where “rescue medicine” is necessary: Severe pain where an opioid is appropriate. Acute crises where drugs are needed as a bandage. The green pharmacy view: Use those drugs as short‑term tools, Then remove or reduce them once the immediate crisis passes, While implementing natural strategies to decrease the need for long‑term prescriptions. [0:56:26] Final Segment  At‑home HPV testing for cervical cancer Ed explains HPV is a major driver of cervical cancer Historically, women had to schedule an in‑office visit for cervical screening, which creates barriers (cost, fear, time, discomfort, lack of insurance). He notes there is now an option for at‑home HPV testing for cervical screening. Intended to increase access for women who aren't getting regular screening. Ed strongly approves of this as a valuable preventive tool and encourages women who haven't been tested to consider it. Ed cites new data showing: Microplastics are found in 100% of human stool samples tested in one study. Higher levels of microplastics are now being linked to gallstones. Broader concerns: Everyday plastic exposure (especially with food and drink) means these particles can: Interact with cells, Drive inflammation, Contribute to premature cellular aging and reduced energy. Practical countermeasures he recommends: Avoid heating food in plastic or placing hot food into plastic containers/wrap (e.g., Saran wrap, plastic take‑out containers). Filter drinking water to remove microplastics (he's trialing the AquaTru system at home, which he says removes 100% of microplastics and much of the fluoride). Improve indoor air quality to reduce airborne microplastic exposure. Ed highlights a serious, long‑term job opening at Nutrition World: Not a summer or short‑term job. Best for someone philosophically aligned with healthy eating and the “green pharmacy” approach. Interested candidates should: Go into the store and speak with Scott, Elisha, or Matt and complete an application.  The post Radio Show / Podcast – May 31, 2026 first appeared on Vital Health Radio.

Most of the mushroom supplements you'll find on Amazon are ground-up fruiting bodies or myceliated grain in a capsule. AHCC is something entirely different. It's a patented fermented extract from shiitake mycelia that has been used in over 1,000 cancer clinics worldwide, backed by more than 100 published studies, and studied specifically for its effects on natural killer cells, HPV clearance, autoimmune conditions, and liver disease. I'd never heard of it until Mimi Lindquist introduced me to it. Lindquist is the co-founder of The Medicine alongside her husband, Chase. She started as a clinical dental hygienist in Seattle, where she observed firsthand how oral health mirrors systemic health, and eventually followed a thread from a patient's HPV recovery all the way to a research compound developed at the University of Tokyo in 1986. In this episode, Lindquist explains what AHCC actually is, how its manufacturing process makes it fundamentally different from any other mushroom product on the market, and why the clinical research behind it is unusually robust for a supplement. The mechanism that makes AHCC interesting is that it doesn't just boost the immune system indiscriminately. It modulates it. For healthy individuals with normal NK cell counts, it doesn't artificially raise them. For people dealing with HPV, cancerous tumors, or autoimmune conditions where the immune system needs more information, it does. This adaptogenic quality is why AHCC can support both an overactive immune response (as in autoimmune) and an underactive one (as in immune suppression from chronic illness or aging) without contradicting itself. I pushed back on this in the conversation because AHCC is a processed product that requires industrial manufacturing to produce, which doesn't fit neatly into an ancestral framework. Lindquist's response was honest: if we were living 100 years ago without microplastics, glyphosate in the rain, and the chronic stress loads of modern life, we probably wouldn't need it. But that's not the world we live in, and the thousands of testimonials she's received from people who had tried everything else and found relief with AHCC are hard to dismiss. Dosing is two capsules daily for general immune support, four for conditions like HPV, Lyme, or autoimmune, and six to eight for serious situations like tumors or advanced liver disease. Their product, Immune Intel AHCC, uses 750 milligrams per capsule with nothing else added. About Mimi Lindquist:  Meagan (Mimi) Lindquist is the co-founder of The Medicin, alongside her husband Chase. With her background as a clinical dental hygienist, culinary nutrition guide, and AHCC educator, she has been helping others prevent disease for over 12 years. Now, Mimi has dedicated herself entirely to sharing the benefits of Immune Intel AHCC, a mushroom supplement unlike any other, to as many people as possible. Instagram: https://www.instagram.com/mimi_themedicin/ Website: https://www.themedicin.com Podcast: https://feeds.captivate.fm/themedicin/ [Discount Code] Use code PRIMALSHIFT for 10% off Mimi's products → https://www.themedicin.com Thank you to this episode's sponsor, Peluva! Peluva makes minimalist shoes to support optimal foot, back and joint health. I started wearing Peluvas several months ago, and I haven't worn regular shoes since. I encourage you to consider trading your sneakers or training shoes for a pair of Peluvas, and then watch the health of your feet and lower back improve while reducing your risk of injury.  To learn more about why I love Peluva barefoot shoes, check out my in-depth review: https://michaelkummer.com/health/peluva-review/  And use code MICHAEL to get 10% off your first pair: https://michaelkummer.com/go/peluva  In this episode: 00:00 Intro  04:24 From dental health to holistic  07:47 Oral microbiome and inflammation  11:58 How AHCC entered her life  16:58 What AHCC actually is  19:17 Origins and NK cell research  28:13 Immune modulation explained  30:40 Fungal network intelligence  32:30 Primal vs processed supplements  36:15 Modern stress and immune support  40:10 Dosing for different needs  41:19 Kids and pets success stories  43:13 Industrial consistency vs foraging  47:37 How long until results  56:10 Final thoughts Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code.

Most people think tracking their protein is enough. The science says what your body actually craves is something far more specific and the person making that argument spent 23 years inside legacy media watching the wellness industry sell women everything from "bikini body in two weeks" to canned protein soda. In this episode, I sit down with Liz Plosser, former Editor in Chief of Women's Health, where she oversaw brands reaching 44 million women. We break down why the nine essential amino acids are what your body is really after when you chase protein, why BCAAs are only a fraction of the picture, and why a study found four of the top six creatine gummies on Amazon contained zero creatine. Liz also opens up about her own supplement stack, her shift from endurance running to heavy lifting, and makes the case that testing instead of guessing is one of the most empowering moves you can make for your health. Then we go deep on the science most people get wrong: why aging women struggle to pull amino acids from food, how essential aminos protect lean muscle even on rest days and for those on GLP-1s, the new research on high-dose creatine for sleep deprivation and Alzheimer's, and why collagen may not deserve the hype. We also cover the menopause misinformation epidemic, the 2002 hormone study that terrified the world, and what Liz puts in her own morning protocol. This conversation will completely change how you think about protein, what you supplement, and how you fuel your brain and body. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The Protein Myth and Why Amino Acids Are What Your Body Really Wants (00:00:56) Protein, Amino Acids, and How Much You Actually Need (00:03:23) The Nine Essential Amino Acids: The Real Building Blocks (00:06:03) BCAAs vs EAAs: Why a Subset Isn't Enough (00:11:50) 23 Years in Wellness Media: What Liz Saw Change (00:14:18) The Menopause Conversation and Why It Exploded (00:23:17) Kion Aminos, Timing, and Whether It Counts Toward Your 100g (00:26:46) Liz's Daily Routine: Aminos, Creatine, and the Morning Glass of Water (00:27:42) Can You Take Aminos While Fasting? (00:29:50) Do Aminos Preserve Lean Mass on Rest Days and on GLP-1s? (00:36:19) Leaving Legacy Media and Finding a New Mission (00:39:14) The New Creatine Research: Sleep, Dosing, and Alzheimer's (00:43:24) How Creatine Reaches the Brain and the Case for 10 Grams (00:44:48) Creatine for Mood and Depression (00:46:12) Collagen: Does It Actually Deserve the Hype? (00:49:40) The Creatine Gummy Scandal: Four of Six With Zero Creatine (00:51:27) Coffee, Cans, and Why Bioavailability Matters (00:54:50) Creatine, Electrolytes, and the 1990s Bodybuilding Hack (00:57:54) Liz's Morning Protocol and Owning Your AM _______ *Thank you to our sponsors*Function Health: https://www.functionhealth.com/louisanicolaTimeline: https://www.timeline.com/partners/neuro-athleticsAirDoctor: https://www.AirDoctorPro.com use promo code NEURO for up to $300 offQualia Life: https://www.qualialife.com/Neuro for an additional 15% off on top of the 50%BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.in... Learn more about your ad choices. Visit megaphone.fm/adchoices

Most people think tracking their protein is enough. The science says what your body actually craves is something far more specific and the person making that argument spent 23 years inside legacy media watching the wellness industry sell women everything from "bikini body in two weeks" to canned protein soda. In this episode, I sit down with Liz Plosser, former Editor in Chief of Women's Health, where she oversaw brands reaching 44 million women. We break down why the nine essential amino acids are what your body is really after when you chase protein, why BCAAs are only a fraction of the picture, and why a study found four of the top six creatine gummies on Amazon contained zero creatine. Liz also opens up about her own supplement stack, her shift from endurance running to heavy lifting, and makes the case that testing instead of guessing is one of the most empowering moves you can make for your health. Then we go deep on the science most people get wrong: why aging women struggle to pull amino acids from food, how essential aminos protect lean muscle even on rest days and for those on GLP-1s, the new research on high-dose creatine for sleep deprivation and Alzheimer's, and why collagen may not deserve the hype. We also cover the menopause misinformation epidemic, the 2002 hormone study that terrified the world, and what Liz puts in her own morning protocol. This conversation will completely change how you think about protein, what you supplement, and how you fuel your brain and body. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The Protein Myth and Why Amino Acids Are What Your Body Really Wants 00:56 Protein, Amino Acids, and How Much You Actually Need 03:23 The Nine Essential Amino Acids: The Real Building Blocks 06:03 BCAAs vs EAAs: Why a Subset Isn't Enough 11:50 23 Years in Wellness Media: What Liz Saw Change 14:18 The Menopause Conversation and Why It Exploded 23:17 Kion Aminos, Timing, and Whether It Counts Toward Your 100g 26:46 Liz's Daily Routine: Aminos, Creatine, and the Morning Glass of Water 27:42 Can You Take Aminos While Fasting? 29:50 Do Aminos Preserve Lean Mass on Rest Days and on GLP-1s? 36:19 Leaving Legacy Media and Finding a New Mission 39:14 The New Creatine Research: Sleep, Dosing, and Alzheimer's 43:24 How Creatine Reaches the Brain and the Case for 10 Grams 44:48 Creatine for Mood and Depression 46:12 Collagen: Does It Actually Deserve the Hype? 49:40 The Creatine Gummy Scandal: Four of Six With Zero Creatine 51:27 Coffee, Cans, and Why Bioavailability Matters 54:50 Creatine, Electrolytes, and the 1990s Bodybuilding Hack 57:54 Liz's Morning Protocol and Owning Your AM _______ Thank you to our sponsors Function Health: https://www.functionhealth.com/louisanicola Timeline: https://www.timeline.com/partners/neuro-athletics AirDoctor: https://www.AirDoctorPro.com use promo code NEURO for up to $300 off Qualia Life: https://www.qualialife.com/Neuro for an additional 15% off on top of the 50% BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

All links here: ⁠https://hunterwilliamshealth.com/linksSS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?If you're a clinician or just researching for yourself, this is the complete user's guide.For entertainment purposes only.Timestamps00:00 Intro01:00 What this masterclass covers03:18 Why SS-31 matters and what makes it different03:46 FDA approval and the Forzenity brand name04:50 Peptide foundations and how SS-31 is made05:52 The SS-31 sequence and the Seto-Schiller naming origin06:40 Mitochondria 101 and why ATP matters07:28 Mitochondrial dysfunction across chronic disease08:34 Cardiolipin, cristae, and Barth syndrome09:34 Why SS-31 is not a direct antioxidant10:46 How SS-31 actually works (the upstream Godfather effect)11:12 Why no receptor means no desensitization13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)14:24 Who should skip it15:34 The three-tier dosing ladder16:54 The FDA-approved 40mg dose and diminishing returns19:08 Dosing by goal (longevity, performance, recovery, healing)19:48 Cycling logic and the 8-12 week framework20:22 When to dose (morning vs night)21:24 What to expect and when (week-by-week timeline)22:20 Why cycle if it doesn't desensitize24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)26:18 Reconstitution and injection technique28:22 What to track (subjective markers and biomarkers)29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs31:28 Stacking for cognition and visceral fat32:26 Troubleshooting "I don't feel anything"33:54 Injection site reactions34:36 When to discontinue and the first-two-week headache window35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)37:54 Research grade vs pharmaceutical cost difference38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)40:30 Final thoughts and where SS-31 sits in the broader picture42:20 Closing

Send us Fan MailOne infant is diagnosed with neonatal opioid withdrawal syndrome every 27 minutes, and rates are rising. In this episode of Journal Club, Ben and Daphna review the Optimized NOW randomized clinical trial, a landmark multicenter study published in JAMA. The trial compared symptom-based dosing,  a single opioid dose given when a withdrawal threshold is met against the traditional scheduled opioid taper in infants managed with Eat Sleep Console. The results are striking: symptom-based dosing reduced time to medical readiness for discharge by nearly two and a half days, and 65% of pharmacologically treated infants avoided scheduled opioid dosing entirely. Could this be the evidence-based approach that finally reshapes how we treat NOWS pharmacologically?----Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial. Devlin LA et al HEAL Evaluation of Limited Pharmacotherapies for Neonatal Opioid Withdrawal Syndrome (HELP for NOWS) Consortium.JAMA. 2026 Apr 25:e265782. doi: 10.1001/jama.2026.5782. Online ahead of print. PMID: 42033722Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show. Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up. You'll Learn: Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one Thank you to our sponsors! - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity Resources: • Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:37 – Intro 03:57 – Pomegranates 10:03 – Discovering Urolithin A & Mitophagy 20:50 – Science vs. Pomegranate Supplements 25:24 – Topical Skincare Science 26:09 – L'Oreal Partnership & Skin Results 33:38 – 15 Clinical Studies & XPRIZE 43:50 – Nature Aging Immune Study 49:22 – Dosing & Daily Routine 51:29 – Future of Mitochondrial Health See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

All links here: https://hunterwilliamshealth.com/links00:00 — Intro and why I'm doing these masterclasses02:42 — What we're covering and the regulatory timeline04:04 — The two users: weight loss vs longevity05:30 — What Retatrutide actually does (the three receptors)06:50 — Why the glucagon receptor makes Retatrutide different07:54 — Weight loss trial data (1mg to 12mg)10:50 — The longevity data: liver fat, ApoB, blood pressure13:14 — Who the lean biohacker user is13:50 — The titration playbook15:32 — Once weekly vs split dosing19:50 — Morning vs night injections21:02 — How far to push the dose (why 8mg is the ceiling)22:50 — How long to stay on and the regain problem25:44 — Longevity maintenance protocol26:34 — Lean user protocol27:24 — Protein and training are non-negotiable29:06 — Side effects and how to manage them30:20 — The heart rate question and why I use taurine32:00 — The weird skin sensitivity issue33:48 — Pairing Retatrutide with testosterone35:56 — Drug interactions (blood pressure, thyroid, insulin)37:02 — Metrics that matter38:42 — How to cycle off correctly39:54 — The most common mistakes40:42 — How to start, what to do if you plateau43:04 — Should you switch from Tirzepatide?45:28 — Combining Retatrutide with other peptides46:50 — The Ten Commandments of Retatrutide use47:50 — The bottom lineToday's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.Let me know what you think. I plan on doing many more of these on every peptide that matters.⚠️ For research and entertainment purposes only. ⚠️

Dr. Stephanie Estima gives a masterclass on the often-overlooked role of lactate in how our bodies work during exercise. She's redefining lactate as a key metabolic signal that can help us get stronger, age better and think sharper. In this solo episode, Dr. Stephanie gets into how lactate is made, how it fuels our energy and why it's so important when we push ourselves hard. Dr. Stephanie is a big fan of sprinting because it helps us build metabolic power and stay strong, and she'll also talk about how to use it right and how to recover well. Episode Overview: (0:00) Introduction — Lactate Is Not the Enemy (2:15) Welcome & Episode Roadmap (4:30) The Myth: How We Got Lactate Wrong (7:00) What Lactate Actually Is (The Biochemistry) (9:30) Why Lactate Forms Even With Oxygen (15:00) The Gear Analogy — Don't Be Metabolically Polite (18:00) Metabolic Flexibility & Why HIIT Matters (22:00) How to Dose Your Sprints (Beginner to Advanced) (24:30) The Lactate Shuttle — Redistribution, Not Waste (28:30) Mitochondrial Biogenesis & Longevity Signals (32:00) Lactate and Your Brain — BDNF, Fog & Cognitive Edge (38:30) Dosing, Recovery Rules & Programming (46:00) Closing — You Are Remodelling Yourself Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep469 We couldn't do it without our sponsors: BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. MUSE - Train your nervous system with feedback, the same way you'd train muscles with resistance. If you are ready to unlock your brain's potential, go to https://choosemuse.com/BETTER or use code BETTER at checkout to get started. PIQUE LIFE - If you want to redefine your afternoon and evening rituals and still feel like yourself the next day, you can get 10% off at https://piquelife.com/better TIMELINE   - Timeline's clinically proven formula is now available at a new, lower price . Mitopure now starts at $79, when you go to https://timelinenutrition.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Blood Sweat & Gear dives into TRT, Trestolone, carb loads, GH testing, Masteron & estrogen, Melanotan 2, cutting strategies, and real coaching insight from experienced bodybuilding coaches. We break down physique critiques, off-season nutrition, health support supplements, and what really matters for progress on cycle and in prep. Featuring Scott McNally and the crew discussing bodybuilding, PEDs, coaching, contest prep, and the science behind getting bigger, leaner, and healthier. 0:00 Intro & Listener Questions 1:00 Trestolone (MENT) as TRT Instead of Testosterone? 4:30 How Top Coaches Use High Days in a Diet 9:00 How to Calculate the Perfect Carb Load 11:45 The Most Important Part of Great Coaching 15:30 Using High Days During the Off Season 19:30 Do Taller Bodybuilders Need More Gear? 24:30 Should You Test GH Labs While Using Growth Hormone? 28:50 300 Test + 300 Masteron — Estimating Estrogen Levels 35:00 Sending PED Samples to Janoshik Explained 36:30 Melanotan 2 Protocols, Dosing & Results 40:45 Should There Be a Coaching Review Website? 44:30 Best Training Tips While Cutting Calories 50:10 Do You Need Health Supplements During a Cruise? 56:00 Live Physique Critique & Feedback 1:03:45 Behind the Schedule & Podcast Talk 1:05:30 Why Everything at Think Big Is Eccentric 1:07:00 Ms. Olympia Joins the Chat 1:10:40 Scott McNally's Client Competing in Germany

Diagnosis, workup, and the four-step treatment protocol for thyroid storm. Hosts: Annaliese Elam, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Thyroid_Storm.mp3 Download Leave a Comment Tags: Critica Care, Endocrine, Thyroid Storm Show Notes I. Pathophysiology & Diagnosis Definition: Life-threatening hypermetabolic state resulting from decompensated thyrotoxicosis. Hormonal Profile: Absolute levels of total T₄/T₃ often mirror uncomplicated thyrotoxicosis; storm is driven by rapid rate of rise, increased catecholamine sensitivity, or increased free T₄/T₃ concentrations. Clinical Presentation: Hyperpyrexia (e.g., 104.2°F) Tachycardia/Arrhythmias (e.g., 155 bpm) Altered Mentation: Agitation, delirium, or psychosis; often the primary differentiator between “storm” and “compensated” hyperthyroidism Warm, moist skin Precipitating Events: Infection, trauma, or surgery Parturition Abrupt cessation of antithyroid medications Burch-Wartofsky Point Scale (BWPS): ≥ 45: Highly suggestive of Thyroid Storm 25–44: Suggestive of impending storm < 25: Storm unlikely Note: High sensitivity but low specificity; can be skewed by unrelated febrile illness. II. Laboratory & Ancillary Findings Thyroid Panel: Characteristically low TSH with elevated free T₄ and T₃. Metabolic Abnormalities: Mild hyperglycemia (catecholamine-induced insulin inhibition) Mild hypercalcemia Elevated LFTs and leukocytosis Cardiovascular: EKG may show sinus tachycardia or atrial fibrillation with rapid ventricular response. III. Management: The Four-Step Blocking Strategy Step 1: Sympathetic Blockade (Beta Blockers) Agent of Choice: Propranolol Mechanism: Non-selective blockade; in high doses, inhibits peripheral conversion of T₄ to T₃. Dosing: PO: 60–80 mg every 4–6 hours IV: 0.5–1 mg over 10 minutes Critical Pitfall: Avoid in patients with acute decompensated heart failure with systolic dysfunction; risk of cardiovascular collapse. Step 2: Inhibition of Hormone Synthesis (Thionamides) Agent of Choice: Propylthiouracil (PTU) preferred over Methimazole in life-threatening storm. Mechanism: Blocks synthesis of new hormone and inhibits peripheral T₄-to-T₃ conversion (decreases T₃ by ~45% in 24 hours). Dosing: 200–250 mg PO every 4 hours Step 3: Inhibition of Hormone Release (Iodine) Agents: Potassium iodide (SSKI) or Lugol’s solution Critical Timing: Must wait at least 60 minutes AFTER thionamide administration. Rationale: Immediate iodine administration provides substrate for new hormone synthesis (Wolff-Chaikoff effect bypass), potentially worsening thyrotoxicosis. Step 4: Inhibition of Peripheral Conversion & Adrenal Support Agent: Glucocorticoids (Hydrocortisone) Mechanism: Inhibits peripheral T₄ to T₃ conversion and treats potential relative adrenal insufficiency. Dosing: 300 mg IV loading dose, followed by 100 mg IV every 8 hours IV. Supportive Care & Avoidance Measures Hyperpyrexia Management: Acetaminophen is the standard of care Avoid Aspirin: Salicylates displace thyroid hormone from thyroid-binding globulin (TBG), increasing free T₄/T₃ levels Volume Resuscitation: Aggressive IV fluids; patients are often profoundly dehydrated May require 3–5 liters of isotonic crystalloid per 24 hours Take Home Points I. Diagnostic Essentials Clinical Diagnosis: Based on hyperpyrexia, cardiovascular dysfunction, and altered mentation. Key Differentiator: Altered mentation (agitation, delirium, psychosis) is often the sole finding distinguishing “storm” from “compensated” thyrotoxicosis. Burch-Wartofsky Point Scale (BWPS): ≥ 45: Highly suggestive of storm. 25–44: Suggests impending storm. < 25: Storm unlikely. Note: High sensitivity, low specificity (e.g., hyperthyroid + flu can score > 45). Triggers: Infection, trauma, parturition, or abrupt cessation of antithyroid drugs. II. The Four-Step Blocking Strategy Beta Blockade (Propranolol): Dose: 60–80 mg PO q4–6h or 0.5–1 mg IV over 10 min. Action: Blocks symptoms and inhibits peripheral T4 to T3 conversion. Caution: Avoid in acute decompensated heart failure with systolic dysfunction. Thionamides (PTU): Dose: 200 to 250 mg every four hours. (note: some resources suggest a loading dose beforehand) Action: Preferred over methimazole; blocks new hormone synthesis and peripheral T4 to T3 conversion. Iodine (SSKI/Lugol’s): Timing: Must wait ≥ 60 minutes AFTER thionamide dose. Action: Blocks hormone release. Pitfall: Early iodine provides substrate for new hormone synthesis, worsening the condition. Glucocorticoids (Hydrocortisone): Dose: 300 mg IV load, then 100 mg IV q8h. Action: Blocks conversion and provides adrenal support. III. Critical Supportive Care Hyperpyrexia: Use Acetaminophen. NEVER Use Aspirin: Displaces thyroid hormone from binding proteins, acutely increasing free T4/T3 levels. Volume: Aggressive fluid resuscitation; patients may require 3–5 L/day due to profound dehydration. Read More

Could GLP-1 medications be the missing piece in treating inflammatory skin disease? In this episode of Science is Skin, Dr. Ted Lain sits down with Dr. Lindsey Bordone — former Columbia University associate professor of dermatology, now in private practice at Bordone Dermatology in Scottsdale, Arizona — for a deep dive into metabolic disease and the skin. Dr. Bordone was among the first dermatologists to prescribe GLP-1 agonists for her patients, and in this conversation she explains exactly why. From the link between hyperinsulinemia and chronic inflammation to the visible skin signs of insulin resistance — skin tags, acanthosis nigricans, forearm hair loss — she makes the case that dermatologists are uniquely positioned to catch metabolic disease before any other specialty. Dr. Bordone walks through how she uses tirzepatide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy), and the emerging triple-G drug retatrutide, including her lab protocols, dosing philosophy, how to manage GI side effects, and the surprising interaction between GLP-1s and estrogen therapy. In this episode: Why high BMI reduces biologic efficacy in psoriasis patients How to check fasting insulin (HOMA-IR) and why most physicians aren't doing it Skin signs of insulin resistance: skin tags, forearm hair loss, and neck skin thickening Tirzepatide vs. semaglutide vs. retatrutide — how to choose and when Retatrutide's remarkable 93% fatty liver clearance rate in clinical trials The truth about sarcopenia and muscle loss on GLP-1 medications Dosing protocols, side effect management, and when NOT to escalate quickly Protein intake recommendations during active weight loss Estrogen and GLP-1 synergy — what dermatologists need to know Lab work to run before and during GLP-1 therapy How to build an insurance case for continued medication coverage Resources mentioned: HOMA-IR fasting insulin/glucose testing AAD resources on metabolic dermatology Bordone Dermatology — Scottsdale, Arizona Enjoyed this episode? Share it with a colleague and leave us a five-star review. Subscribe so you never miss an episode of Science is Skin. To watch this and other episodes, be sure to check out our YouTube page DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.See omnystudio.com/listener for privacy information.

In this high-yield, no-fluff episode, Dennis is joined by Dr. Michael Falk, a pediatric emergency medicine physician, former academic, and combat-experienced relief worker who has run airways in Haiti post-earthquake, Mosul during the ISIS fight, Ukraine, and Gaza. They break down exactly why pediatric airways are a completely different beast in prolonged field care and give you field-proven tactics that actually work when you're the only one there with a BVM and a prayer.Key Takeaways You Can Use TomorrowPositioning is everything: One to two inches under the shoulders (or whole body) prevents automatic obstruction from the massive occiput.Adjuncts > early tube: NPA or OPA + side-lying (gravity is your friend) can keep you from tubing in the field.Tube sizing rule: Child's pinky ≈ ET tube diameter. Depth = 3× tube size. Always go smaller — you can ventilate, you can't un-damage a ripped airway.Intubation mindset: Kid airway is more anterior and cephalad. Slow down, work your way in, or you'll be in the esophagus.GCS decision:

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-483 Overview: Human papilloma virus (HPV) vaccination can prevent most cases of cervical cancers, yet global coverage remains critically low. In this episode, we discuss the latest evidence on single-dose vs. two-dose HPV vaccination regimens, empowering you to counsel patients and families with confidence, address barriers to series completion, and maximize cancer prevention in your adolescent population. Episode resource links: Noninferiority of One HPV Vaccine to Tow Doses.  The New England Journal of Medicine.  2025.  Kreimer AR, Porras C, Liu D, et al. Cancer Prevention and Early Detection Facts and Figures.  American Cancer Society (2025).  2025.  Rick, Alteri, Deana Baptiste, Emily Butler Bell, et al. Guest: Anne Powell, MD   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-483 Overview: Human papilloma virus (HPV) vaccination can prevent most cases of cervical cancers, yet global coverage remains critically low. In this episode, we discuss the latest evidence on single-dose vs. two-dose HPV vaccination regimens, empowering you to counsel patients and families with confidence, address barriers to series completion, and maximize cancer prevention in your adolescent population. Episode resource links: Noninferiority of One HPV Vaccine to Tow Doses.  The New England Journal of Medicine.  2025.  Kreimer AR, Porras C, Liu D, et al. Cancer Prevention and Early Detection Facts and Figures.  American Cancer Society (2025).  2025.  Rick, Alteri, Deana Baptiste, Emily Butler Bell, et al. Guest: Anne Powell, MD   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

In this Herb of the Month episode, I share one of my favorite heart centered nervines, Motherwort. Leonurus cardiaca is an ancient plant with a long history of use for nervousness, heart rhythm support, insomnia, and overall cardiac care.

Editor's Summary by Linda Brubaker, MD, Deputy Editor and Anne Cappola, MD, Senior Editor of JAMA, the Journal of the American Medical Association, for articles published from April 25-May 1, 2026.

In this episode of the Flex Diet Podcast, I sit down with creatine researcher Dr. Darren Candow from the University of Regina to break down what the research actually says about creatine for muscle, performance, and body composition—plus the newer interest in brain health, aging, and longevity. We dig into practical dosing (including higher-dose ideas for bone and brain), why timing probably doesn't matter much, and what the data shows on safety, side effects, and common myths like hair loss. We also talk about creatine in special contexts like sleep deprivation, jet lag, concussion/TBI potential, and vegan or low-creatine diets, along with how caffeine might (or might not) interfere. If you want an evidence-based, real-world guide to creatine, this one's for you. Sponsors: Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 04:00 How Candow Started Creatine 06:10 Glutamine Reality Check 07:17 Top Supplements Today 08:23 NAD Hype vs Evidence 11:36 Creatine Dosing and Timing 15:06 Brain Uptake and Sleep Loss 18:17 Safety Diet and Essentiality 21:49 Harris Studies and Dose Ranges 24:30 Creatine for Concussion Prevention 26:31 High Dose Game Prep 27:12 Creatine Beyond Sports 29:16 Soccer Cognition Hits 31:38 Caffeine Creatine Myth 35:11 Caffeine Dosing Timing 37:32 Creatine Bone Findings 39:22 Bone Research Reality 43:39 Heart Health Potential 44:20 Creatine Forms Hype 46:30 Future Creatine Research 47:51 Wrap Up Resources 48:37 Conference Manual Plug 51:29 Medical Disclaimer Outro Flex Diet Podcasts you may enjoy: Episode 351: Brain Rehab that Works: Tools for Concussions and Migraines with Dr. Ayla Wolf YouTube: https://www.youtube.com/watch?v=DUcFEjpj8mA Episode 318: Could GAA be the Next Creatine with Dr. Guillermo Escalante YouTube: https://www.youtube.com/watch?v=MTlU7RLnEhg Connect with Dr Candow: Instagram: https://www.instagram.com/dr.darrencandow Website: https://creatineforhealth.com/prof-darren-candow-phd Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

In this episode, we explore how pregnancy reshapes the pharmacokinetics of psychiatric medications — and what that means for your patients. Can stopping a mood stabilizer actually put a pregnancy at greater risk than continuing it? Dr. Amanda Koire breaks down the evidence. Faculty: Amanda Koire, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know Pregnancy's Impact on Medication Efficacy and Dosing Considerations

In this episode of the NCS Podcast Hot Topics series, host Richard Choi, DO, FNCS, is joined by Melissa Dang, PharmD, BCCCP, neurocritical care pharmacist at MedStar Franklin Square Medical Center, to discuss the article "Levetiracetam Dosing Optimization in Neurocritical Care Population: Neuro-ARC Study", recently published in Neurocritical Care. Their conversation explores how augmented renal clearance may reduce levetiracetam exposure in neurocritical care patients and the implications for seizure management in clinical practice. Dr. Dang breaks down the study's pharmacokinetic modeling, highlights key dosing findings and reviews the patient factors most strongly associated with increased drug clearance. She also discusses the study's limitations and emphasizes the need for caution when applying its findings across broader clinical settings. The views expressed on the NCS Podcast are solely those of the hosts and guests and do not necessarily reflect the opinions or official positions of the Neurocritical Care Society.

In this clinically rich episode, host Dr. Ted Lain sits down with board-certified dermatologist and global skin cancer expert Dr. Todd Schlesinger — AAD Board of Directors member, Mohs surgeon, clinical assistant professor at George Washington University School of Medicine, and medical director of the Clinical Research Center of the Carolinas — for a deep dive into systemic and targeted therapies for non-melanoma skin cancer (NMSC). The doctors begin with a thorough breakdown of the hedgehog signaling pathway (PATCHED, Smoothened, GLI-1 transcription) and how mutations in this pathway drive basal cell carcinoma (BCC) growth. They compare the two FDA-approved hedgehog pathway inhibitors (HHIs) — vismodegib (Erivedge) and sonidegib (Odomzo) — covering their mechanisms of action, volume of distribution differences (16–18L vs. ~9,000L), indications for locally advanced and metastatic BCC, how to define "locally advanced," and complete vs. partial response rates. Dosing strategies are addressed in detail, including alternate-day dosing and treatment breaks backed by the MIKIE study and STEVIE safety study. For managing the most common adverse events — muscle cramps, dysgeusia, weight loss, and fatigue — Dr. Schlesinger shares his clinical protocol using L-carnitine supplementation (1,500–2,000mg liquid, started 2–4 weeks before therapy) along with calcium and CoQ10. The conversation then moves to PD-1 and PD-L1 checkpoint inhibitors for locally advanced and metastatic cutaneous squamous cell carcinoma (cSCC) and BCC, covering cemiplimab (Libtayo), pembrolizumab (Keytruda), and nivolumab (Opdivo). The hosts explain the immune checkpoint mechanism using a memorable analogy, discuss how UV exposure upregulates PD-1 on tumor cells, and explore the practical realities of dermatologists prescribing infusion-based immunotherapy — including multidisciplinary care team logistics, buy-and-bill considerations, and when to partner with oncology. The episode closes with an exciting look at the pipeline: intralesional therapies for nodular and superficial BCC from companies including Verica, iViva, PHIO, and Feldan, red light PDT for superficial BCC nearing FDA approval, and the broader question of where these drugs fit as neoadjuvant, adjuvant, or primary therapies — and what complete response benchmarks (80–95%) dermatologists should expect before adopting non-surgical primary options. To watch this and other episodes, be sure to check out our YouTube page DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.See omnystudio.com/listener for privacy information.

Testosterone is often misunderstood in women—and too often reduced to oversimplified or fear-based messaging. The reality is this: testosterone can be a safe and effective therapy for women—particularly for Hypoactive Sexual Desire Disorder (HSDD) and other symptoms of low testosterone—when it is dosed appropriately. And that's the key. When dosing is right—meaning carefully adjusted for female physiology and monitored over time—women are not limited to a single option. They can choose the delivery method that fits their body and their life. In this video, I walk you through:

What if everything you thought you knew about peptides—and even GLP-1s—was only scratching the surface? In this episode, we sit down with Jay Campbell to unpack the rapidly evolving (and often misunderstood) world of peptide therapy, from regulation challenges and dosing risks to the truth about purity and sourcing. Jay shares what's really happening behind the scenes with major pharmaceutical players, what's coming next with compounds like Retatrutide, and why so many people are getting GLP protocols wrong. The conversation goes beyond hype, diving into how to work with your biology through smarter protein strategies, muscle-building, and personalized optimization. If you're curious about the future of longevity medicine, this episode will completely shift your perspective.Jay Campbell is a health optimization pioneer, longevity and peptide expert, and five-time international bestselling author. He is the co-founder of BioLongevity Labs and has spent more than two decades studying metabolic health, hormone optimization, and aging biology. Jay's work blends cutting-edge science with intuition and self-awareness, helping people understand how to work with their biology rather than override it.SHOW NOTES:0:40 Welcome to the podcast!2:21 About Jay Campbell3:05 Welcome him to the show!3:45 Current regulation of peptides6:35 Challenges with dosing yourself8:35 Big compounders like Eli Lilly9:25 What's on the horizon!10:15 Research companies vs Telehealth12:25 Cheap vs pure peptides19:05 BioLongevity Labs testing20:08 Peptide origin myths!21:17 Coming soon22:53 *APOLLO NEURO*24:54 *CALOCURB*26:47 GLP-3 Retatrutide29:19 The wrong doses of GLPs32:26 GLP-4s, 5s, and 6s36:18 What we got wrong about GLP-1s39:15 Protein goals & building muscle44:39 Adding in Calocurb 46:10 Once/week dosing47:39 Where to find him47:49 Thanks for tuning in!RESOURCES:Apollo Neuro - Discount code: BIOHACKERBABES for $90 off Smart Vibes bundleCalocurb - Discount code: RENEE10Website: Biolongevitylabs.com - Discount code: BIOHACKERBABESInstagram: Jay CampbellInstagram: Biolongevity LabsYouTubeFacebookXBook: Metabolic AwakeningSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems.  Dr. Sherr also shares how he's used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework. Sponsors: TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde CODE: DRMIKE Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Coming up: ISSN 2026: https://www.sportsnutritionsociety.org/ Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:11 Why Methylene Blue Now 04:29 Scott Cher Origin Story 05:05 Health Optimization Framework 07:08 Transcriptions and Safe Sourcing 08:46 Natural vs Synthetic Debate 11:49 How Methylene Blue Works 17:42 Who Benefits Most 22:13 Athletic Performance and Recovery 29:41 Dosing Timing and MAOI Effects 32:13 Mitochondria and Fertility 32:28 Energy Anxiety and Brain Fog 33:13 Depression Beyond Serotonin 35:30 Stress Pathways and Cell Danger 37:00 ADHD or Sympathetic Overdrive 38:50 Recovery Metrics and Downregulation 42:21 GABA Support and BBB Clues 47:50 Building Mitochondrial Capacity First 51:35 Methylene Blue Dosing Guide 57:54 Where to Learn More 01:00:24 Podcast Wrap and Disclaimer  Flex Diet Podcasts you may enjoy: Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw Connect with Dr Sherr: Instagram: https://www.instagram.com/drscottsherr/ Website: https://drscottsherr.com/ YouTube: https://www.youtube.com/@drscottsherr Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

Dr. Derek Stitt and Dr. Page B. Pennell discuss antiseizure medication management during pregnancy and postpartum, based on the MONEAD study.  Show citation:  Pennell PB, Li D, Kerr WT, et al. Antiseizure Medication Dosing Strategy During Pregnancy and Early Postpartum in Women With Epilepsy in MONEAD. Neurology. 2026;106(2):e214483. doi:10.1212/WNL.0000000000214483 

Dr. Derek Stitt talks with Dr. Page B. Pennell about antiseizure medication management during pregnancy and postpartum, based on the MONEAD study.  Read the related article in Neurology®.  Disclosures can be found at Neurology.org. 

Are you on tirzepatide or semaglutide and struggled with inconsistent weight loss and side effects? On this episode of On The Pen, Dave Knapp and Dr. Ian Ellis dive into the surprising variability of GLP-1 dosing (retatrutide, tirzepatide), even when the weekly dose remains the same. We explore how these subtle dosage changes can lead to frustrating glp-1 side effects and why many individuals eventually give up on their weight loss medication. This new way of thinking about glp-1 dosing could change the obesity medicine game. Referenced Links: http://www.OTPLinks.com00:00 Why most GLP-1 users are never on the same dose twice01:55 Dr. Ian's background: trainer, nutritionist, ER physician04:00 His obsessive relationship with food and body composition07:45 The two impossible choices: obsession or obesity10:12 How medical school destroyed his health10:25 A colleague mentions Ozempic for the first time11:35 His first dose and what real satiety feels like13:00 Why the same dose felt worse every single week15:00 30 lbs lost but the body scan results were horrifying17:30 Why elderly patients are especially at risk on GLP-1s18:35 Patient case: Pat May, 310 lbs, lost over 100 lbs20:45 Semaglutide half-life and dose stacking explained24:50 The therapeutic window and finding your ideal level26:30 Why the dosing protocol was built for trials not people28:00 You are never on the same drug level twice29:00 Patient case: Mary Alice lost 30 lbs below the starting dose32:00 The math behind calculating your precise GLP-1 level35:00 The VoaFit app and making precision dosing scalable36:00 Their patients lost more weight using half the medicine39:30 Why 40 to 70 percent of people quit GLP-1s42:00 Compounding pharmacies and the case for flexible dosing46:00 Using GLP-1 as a thermostat dial for your appetite56:45 Where precision dosing is available now58:30 Beyond GLP-1s: applying this to testosterone and more1:05:30 Why hitting the dose ceiling kills long-term results1:07:00 Dr. Ian's outcome: off GLP-1s completely1:10:00 Fixing a broken one-size-fits-all dosing paradigm1:13:00 How to find Dr. Ian Ellis and VoaFit

In this episode, Eric Malzone hangs out with Jim LaValle—a legend in metabolic health who's been deep in this world for over 40 years—for a real conversation about GLP-1s, peptides, and what it actually takes to build a healthier, longer life. Jim gets honest about why these drugs can be a game-changer but also why so many people use them wrong, the sketchy side of the "research only" peptide market, and which peptides he's actually excited about for gut health, hormones, and fixing your sleep. They also talk about why the fitness industry hasn't quite cracked the longevity code yet, and how the whole landscape is shifting thanks to consumer demand, post-COVID wake-up calls, and even AI. It's a no-BS chat that'll make you rethink quick fixes and appreciate the basics again. Key Takeaways

Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website: ⁠https://hunterwilliamshealth.com/⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠⁠⁠In this episode, I'm breaking down two peptides that I think are about to blow up: mazdutide and survodutide. Both are GLP-1 and glucagon dual agonists. Think of them like retatrutide minus the GIP component. And that glucagon piece is what makes them special.I go through the trial data for both compounds. We're talking up to 21% weight loss with mazdutide and 80% liver fat reduction. Survodutide earned FDA breakthrough therapy designation for MASH based on a 62% resolution rate. These are serious numbers.Here's what most people don't realize. These two peptides are NOT the same. Mazdutide runs close to a 50/50 split between GLP-1 and glucagon agonism. Survodutide is roughly 8 to 1 in favor of GLP-1. That changes everything about tolerability, appetite suppression, and how much metabolic burn you're actually getting.I also cover practical use cases. Cycling off reta without losing momentum. Choosing between the two based on whether you need more appetite control or more energy expenditure. Dosing guidance for people just starting out. And why escalating too fast is still the number one mistake people make with GLP-1 peptides.

Have you heard of DMSO and are among the many already using it?Or have you heard of DMSO but are wondering how to use it?Either way, this interview is for you!Amandha Vollmer, one of the leading experts on DMSO, joins me for our 5th interview on the podcast for a real deep dive into this remarkable compound.Not only has she written a fabulous and very practical book on the topic, Healing with DMSO, which includes a multitude of applications and recipes, she also formulates products containing DMSO that you can buy directly.Amandha breaks down what DMSO is, where it comes from, how it works in the body, safety considerations, practical daily applications for healing, pain relief, and more.Grab a pen, you may want to take notes on this one!In this episode:5:28 What is DMSO: a natural product from trees extracted from lignin7:08 How Amanda discovered DMSO in naturopathic college8:19 Amanda's unique DMSO blending and formulations14:00 Purity grades explained: why 99.995% pharmaceutical grade matters15:00 How DMSO works in the body - crosses the blood-brain barrier, hydrates tissues, delivers nutrients17:15 DMSO for emergencies - stopping strokes and heart attacks18:55 Collagen remodelling and why DMSO interacts with Botox and fillers25:43 Cautions around amalgams, tattoos, false lenses, and metals in the body32:45 DMSO vs MSM: the key chemical and functional differences36:51 Skin sensitivity explained: why some people react and what it really means37:07 Dosing for animals, babies, and sensitive skin39:27 Safety fundamentals40:44 Prep your body first: magnesium, hydration, and liver support42:49 Material safety: plastics, rubber, and surfaces DMSO can dissolve43:10 Alcohol interactions and why you should never mix the two46:35 Burn healing and preventing scars with DMSO53:30 How long DMSO stays in the body and metabolite clearance58:10 Reducing DMSO odour: polyphenols, pomegranate juice, and quercetin1:09:13 Daily maintenance use: Amanda's personal DMSO routine1:21:27 Blood pressure and breathing: natural alternatives to medication1:22:54 Hibiscus and chia seed recipe for hypertension1:25:47 How DMSO modulates inflammation and supports whole-body healing1:30:11 Why DMSO and magnesium work better togetherShare this one around, it can help many!If you enjoyed this episode, please share and consider going to www.sovereigncollective.org/shop to check out my offerings and get a deal while supporting the podcast. I'll be adding more great offerings there over time.Find Amandha:https://yummy.doctor/ (main hub and membership community)https://yumnaturals.store/ (natural skincare, hair care, dental care products)https://dmso.store/ (all DMSO blends and products)https://healingwithdmso.com/ (book information and excerpts)---------------------------------------------Find me:Facebook: https://www.facebook.com/saschakalivoda/IG: https://www.instagram.com/saschaksays/Website: www.sovereigncollective.orgYou Tube: https://www.youtube.com/@saschasays/videosBitchute: https://www.bitchute.com/channel/Tfl1Zo021FcXEmail: sascha @ sovereigncollective.org

Welcome back to Embody Radio! Today's episode is one of those "nerdy girl deep dives" that I've been so excited to share with you. I sat down with David Watumull, a researcher and formulator who has spent over two decades in the astaxanthin space, starting all the way back in the algae ponds of Kona, Hawaii as a high schooler, and working his way through pharmaceutical-grade research and development.   If you've never heard of astaxanthin, or if you've heard of it but kind of wrote it off as "just another antioxidant," this episode is going to change that for you. We get into the weeds on what makes astaxanthin structurally different from other antioxidants (spoiler: it actually spans the entire cell membrane like a bridge, while things like vitamin C just sit on the outside), how it fights free radicals without becoming a pro-oxidant itself, and why it matters for literally everyone, not just people who are "old enough to worry about aging."   We cover a LOT of ground in this one: What oxidative stress actually is (explained like you're five) and why modern life accelerates it How astaxanthin works upstream of inflammation like a thermostat, not an on/off switch The connection between oxidative stress and brain fog, mood, sleep, joint pain, and skin health Why your 3pm energy crash might be a bigger red flag than you think How astaxanthin crosses the blood-brain barrier and promotes neuroplasticity and BDNF production The NIH Interventions Testing Program results Astaxanthin's role as "internal sunscreen." What that means and what it doesn't Why it pairs so well with omega-3s, creatine, and other longevity supplements Dosing guidance David's personal story from the algae ponds to pharmaceutical research to launching AX3   I've been personally taking astaxanthin for about a month now, and I'm noticing calmer mental energy, better recovery from training, and significantly improved REM and deep sleep. This one is backed by over 4,000 peer-reviewed papers and 100+ human clinical trials, so we're not just vibing here, there's real science.   If you want to try AX3 for yourself, use code EMBODY at ax3.life for a 20% discount. This is one of those foundational supplements I think more of us should be prioritizing.   Fitness, health, and holistic wellness for $22/month Interested in a luxury 1:1 online health coaching experience? Look no further than FENIX ATHLETICA, where we fuse science and soul for life-long transformation (inside AND out). For the high-achieving hot girls that want to recover better, support glowier skin, and promote longevity through better cellular health, get 20% off your first order of Mitopure and make wellness easier than ever. Follow me on Instagram Follow EMBody Radio on Instagram

Send us Fan MailKasey welcomes listeners to the PT Snacks podcast for physical therapists and students and introduces a brief episode on Ehlers-Danlos syndrome (EDS). Kasey highlights common patient issues such as joint pain, dislocations, tendinitis, and muscle cramps, and discusses how physical therapy can improve quality of life through resistance training, proprioception, balance, aerobic and functional conditioning, pain neuroscience, and graded exposure to reduce kinesiophobia. 00:00 Welcome and Disclaimer00:18 Episode Focus on EDS01:21 EDS Types Overview02:20 Hypermobility EDS Basics02:33 Why Collagen Matters03:16 PT Goals Pain and Fear04:02 Training Approaches for hEDS04:31 Load Management and Recovery05:48 Lifestyle Factors Sleep Stress06:52 Wrap Up and ContactNeed CEUs?Unlock unlimited online courses, live webinars, and certification-prep programs with MedBridge. You'll get thousands of accredited, evidence-based courses. Use code PTSNACKSPODCAST at checkout to save over $100. Student? Use code PTSNACKSPODCASTSTUDENTSupport the showNeed CEUs? Unlock unlimited online courses, live webinars, and certification-prep programs with MedBridge. You'll get:Thousands of accredited, evidence-based courses across multiple specialties (PT, OT, AT, SLP) that count for state-license CEUs. Access anytime, from your office, phone, or home—perfect for busy clinicians. One annual subscription, no per-course fee. Special offers:Use code PTSNACKSPODCAST at checkout and save over $100.Students use code PTSNACKSPODCASTSTUDENT for a discounted annual plan.Studying for the NPTE? Check out PT Final Exam — they've helped thousands of students pass with confidence. Use code PTSnacks at checkout for a discount.Stay Connected!Follow so you never miss an episode. Send your questions via email to ptsnackspodcast@gmail.comJoin the email list ...

Send a textIn this episode of Journal Club, Ben and Daphna review a retrospective cohort study exploring the effects of higher caffeine maintenance dosing on BPD and neurodevelopmental outcomes. They discuss the transition from the standard CAP trial doses to higher regimens for infants born at or before 28 weeks gestation. Does an average daily dose of over six milligrams per kilogram reduce severe BPD or improve Bayley cognitive scores at six months? Tune in as they debate the safety, clinical implications, and their own unit's practices regarding caffeine management in the NICU!----Effects of higher caffeine dosing on rates of bronchopulmonary dysplasia and neurodevelopmental outcomes. Fleishaker S, Kazmi SH, Mavrogiannis N, Street H, Ravuri H, Moinuddin T, Pierce K, Verma S.J Perinatol. 2026 Feb 23. doi: 10.1038/s41372-026-02593-1. Online ahead of print.PMID: 41731043Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Episode 341 hosts Dr John Leonardo (Anaesthesiologist from Toronto, Canada) John join us in Chapter 13 of our Masterclass series of episodes. Here we host global experts with significant experience to teach us about fillers, bio-stimulators, bio-remodellers, polynucleotides, other injectable products and techniques. (For toxin insights, check out our other mini-series, 'The Tox Talks') In Chapter 13 we discuss a sub-niche of aesthetics that John has developed - male sexual aesthetics. We first explore the taboo and stereotypes behind these sorts of male concerns as well as unpacking some of the functional issues that may also need addressing.  We then outline the five main treatments that John offers:  Penile toxins (GroTox®) for flaccid hang and erectile function Penile filler (P-Girth®) for girth +/- gland enhancement Scrotal toxin (ScroGro®) to relax scrotal retraction, reduce wrinkles and treat hyperhidrosis Scrotal filler (ScroGro®) to increase scrotal size Anal toxin (RimTox®) to relax the internal sphincter for receptive anal sex. John discusses his consultation technique with male aesthetic patients and for each treatment we cover dosing, techniques, product choice, aftercare, costs and complications.  00:00 Introduction  00:40 Meet Dr John Leonardo 01:28 What Is Male Sexual Aesthetics? 03:46 Consultation and Psychology 06:06 How John He Entered The Niche 10:07 Grotox® Mechanism 14:36 Grotox® Protocol and Dosing 21:16 Aftercare, Risks & Longevity 26:34 Pricing, Naming and Industry Context 31:37 P-Girth® - Penile Fillers 35:51 Hybrid Filler and Technique 39:48 Inducing Erections Before Filling 43:32 Penis Sculpting 49:13 Penile Vascular Occlusions 59:12 ScroGro® Toxin Benefits and Method 01:02:24 ScroGro® Filler Protocol 01:06:42 RimTox® 01:13:12 Wrap Up and Resources 01:16:19 Final Outro and Links JOIN THE WAITING LIST FOR IA COMMUNITY (OUR NEW APP) ALL IA LINKS & CONTACT INFORMATION  

In this episode, Dr. Jockers sits down with Ari Whitten to break down how red and near-infrared light therapy works and why it has become such a powerful tool for healing, energy, and recovery. You'll learn how light interacts with the body at the cellular level and why it matters far beyond skin health. They also unpack why this topic deserves more attention in the world of functional medicine.   Ari explains how photobiomodulation can support mitochondrial function, reduce inflammation, and promote repair in tissues throughout the body. You'll hear how red light may influence everything from brain health and athletic recovery to fat loss and healthy aging. The conversation also explores the difference between local and whole-body benefits.   You'll also learn what to look for in a quality red light device and why specifications like intensity, coverage, and design matter more than most people realize. Dr. Jockers and Ari walk through how to think about using red light effectively for your goals while clearing up common misconceptions around this technology. Along the way, they reveal why proper light exposure may be more important than many people think.   In This Episode:  00:00 Stem Cells and Light 00:26 Episode Overview and Guest 06:40 Why Rewrite the Book 11:08 How Light Affects Biology 15:21 Red and Infrared Explained 17:31 Optical Window and Benefits 23:12 Cell Sensitivity and Dosing 28:23 Red vs Near Infrared Depth 35:31 C15 Longevity Pitch 37:22 Red Light Skin Benefits 40:40 Collagen Tug of War 43:39 Choosing a Quality Mask 47:33 Panels Versus Masks 50:31 Systemic Effects Explained 54:36 Stem Cells and Melatonin 01:00:05 Avoiding Junk Panels 01:07:42 Testing and Device Guide 01:09:31 Book Wrap and Sun Wisdom 01:10:52 Final Takeaways and Outro   If you want practical, natural strategies to balance your hormones, heal your gut, boost your energy, and slow aging, don't miss The Dr. Josh Axe Show. Dr. Axe blends ancient wisdom with cutting-edge science and brings on world-class experts for unfiltered conversations you won't hear anywhere else. Transform your health from the inside out and subscribe to The Dr. Josh Axe Show, with new episodes every Monday and Thursday.   Looking for a delicious snack that's good for you? Paleovalley Superfood Bars are packed with organic, whole food ingredients like collagen protein, kale, and blueberries—providing all the nutrients your body needs. With flavors like Lemon Meringue and Red Velvet, you can enjoy a treat that supports gut health, joint function, and even wrinkle-free skin. Visit paleovalley.com/jockers and use the code Jockers to save 15% on your order today.   Support healthy aging from the inside out with Fatty15—a 100% pure, patented, vegan C15 supplement designed to help strengthen cell membranes and support long-term cellular health. Get an additional 15% off the 90-day Subscription Starter Kit when you go to fatty15.com/drjockers and use code DRJOCKERS at checkout. Take the guesswork out of your health with Superpower Health. With one simple blood draw, they analyze more than 100 biomarkers to give you a clearer picture of your heart health, hormones, metabolism, nutrient levels, toxins, and more. You'll get personalized insights through their app, along with access to on-demand clinicians who can help you better understand your results. Superpower has now lowered their membership price to just $199, and as a listener, you can get an additional $20 off when you visit superpower.com and use the code JOCKERS at checkout.     "One of the biggest benefits of red light therapy is how it supports healing, energy, and recovery all at once."      Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio   Resources: Visit paleovalley.com/jockers for a 15% discount  Visit fatty15.com/drjockers and use code DRJOCKERS at checkout Visit superpower.com and use the code JOCKERS at checkout     Connect with Ari Whitten: Book:  https://amzn.to/4cbOYnd   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

It's In the News, a look at the top headlines and stories in the diabetes community. This week's top stories: Stem Cell Islet Therapy Partnership, "Lyla's Law" Type 1 Testing Debate, Patient-Led Insulin Dosing for Gestational Diabetes, $3 Semaglutide Manufacturing, FDA GLP-1 Compounding Crackdown Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  transcript with links:  Welcome! I'm your host Stacey Simms and this is an In The News episode.. where we bringing you the top diabetes stories and headlines happening now. A reminder that you can find the sources and links and a transcript and more info for every story mentioned here in the show notes. I am definitely feeling better – that lingering cold is gone – but whew still recovering from non stop travel for the past five weeks. I have a great strech of time her at home, then going to Vegas for Brekathorugh T1D at the end of the month and we have two club 1921 events in April – Atlanta and Philly. Before we jump into the news – I need your community commercials! These have been a lot of fun, I announced them late last year – your voice on the show. All the instructions it's very easy in the show notes. Okay.. our top story this week: XX A biotech company developing stem-cell treatments for type 1 diabetes has announced a new research partnership aimed at improving the survival of transplanted insulin-producing cells. NewcelX, a clinical-stage company based in Switzerland, said it will work with Eledon Pharmaceuticals to study a combination approach. The goal is to help transplanted cells survive longer in the body by reducing the immune response that often leads to transplant rejection. If successful, the strategy could support longer-lasting islet cell replacement and move the therapy closer to becoming a functional treatment for people with type 1 diabetes. However, the companies have not yet released any safety or effectiveness data on the combination treatment, and financial details of the partnership were not disclosed. The research agreement is focused on exploring whether combining stem-cell-derived islets with targeted immune therapy can lead to longer-lasting cell transplants and improved outcomes for people with type 1 diabetes. https://www.stocktitan.net/news/ELDN/newcel-x-announces-strategic-collaboration-with-eledon-d10l1vqdofls.html XX Debate this week in the UK on whether testing for type 1 diabetes should become mandatory when children present with symptoms. The Westminster Hall debate, scheduled for 9 March, will consider calls for routine testing of babies, toddlers and young children who show signs associated with the condition. It follows a petition backing the move, dubbed 'Lyla's Law', which passed 121,000 signatures in December 2025. The campaign was launched by John Story after his two-year-old daughter, Lyla, died from diabetic ketoacidosis (DKA) on 3 May 2025, 16 hours after being diagnosed with tonsillitis. https://www.nursinginpractice.com/clinical/diabetes-and-endocrinology/diabetes-community-urged-to-call-on-mps-to-attend-lylas-law-debate/ XX     A new study suggests that people with gestational diabetes who adjust their own insulin doses may reach healthy blood sugar levels faster than those whose doses are adjusted by clinicians. Half of the participants were assigned to adjust their own insulin doses using a simple rule: increase the dose by two units if fasting blood glucose was above 95 mg/dL, decrease it by two units if it dropped below 70 mg/dL, and keep the same dose if levels fell in between. The other half had their insulin adjusted by clinicians through weekly reviews. By the end of pregnancy, both groups had similar average fasting glucose levels before delivery: about 89 mg/dL in the patient-led group and 90 mg/dL in the clinician-led group. However, those adjusting their own insulin reached their blood sugar targets more quickly, averaging 1.8 weeks compared with 2.5 weeks for those managed by clinicians. The study also found lower risks of certain complications among the patient-led group. https://www.medscape.com/viewarticle/self-insulin-dosing-leads-control-gestational-diabetes-2026a1000729 XX   A blockbuster anti-obesity and diabetes drug could cost as little as $3 per month to manufacture once it goes off patent later this month, researchers said Friday, providing a major opportunity to boost health in low and middle-income countries.   Semaglutide, the active molecule in Novo Nordisk's Ozempic and Wegovy will lose patent protection in countries such as Brazil, China, and India later this month, and researchers identified 150 countries where it was never patented. These researchers estimated it will cost as little as $3 to produce a month's supply of semaglutide, which in its branded form sells for around $200 a month in the United States. Another of the study's authors, Professor Francois Venter at the University of Witwatersrand in South Africa, said drugs to treat HIV, TB, malaria, and hepatitis are now available at prices close to production costs but still sufficient for generic manufacturers to operate. https://www.sciencealert.com/weight-loss-drugs-could-cost-just-3-a-month-to-make-as-patents-end XX Here in the US the FDA is stepping up its efforts to combat widespread GLP-1 drug compounding. In its latest offensive, the agency has unleashed a fresh set of 30 warning letters targeting telehealth companies it says make "false or misleading" claims about compounded versions of popular obesity drugs. The FDA says Compounded drugs can be important for overcoming shortages or meeting unique patient needs—but compounders should not try to compound drugs in a way that circumvents FDA's approval process." https://www.fiercepharma.com/pharma/fda-ramps-crackdown-glp-1-drug-compounders-fresh-batch-30-warning-letters XX   Check your infusion sets for an issue: Unomedical, a subsidiary of Convatec and a supplier of insulin infusion sets to diabetes tech firms, has received a warning letter from the FDA. Inspectors raised concerns with leaking infusion sets, following a regulatory assessment of Unomedical's facility in Reynosa, Mexico, last summer. Unomedical supplies infusion sets to insulin pump makers including Medtronic, Tandem Diabetes Care and Beta Bionics. In a Feb. 3 statement, Convatec said the letter focuses on reporting procedures and quality protocols and does not place restrictions on producing, marketing or distributing any of Unomedical's products.  Unomedical told the FDA in its responses that it plans to conduct a retrospective review of complaints involving serious injury or death by January and conduct additional training on complaint handling by May.   https://www.medtechdive.com/news/fda-warns-insulin-infusion-set-maker-unomedical-over-leaks-mishandled-comp/813503/ XX Nearly four in ten people with type 2 diabetes do not take their medications as prescribed, according to a new research review published in Diabetologia in November 2025.   Researchers examined existing studies on medication adherence, including how often patients miss doses, why it happens, and what strategies may help. They estimated that about 38% of patients with type 2 diabetes are not fully adherent to their medications.   Adherence rates vary depending on the type of medication. About 63% to 68% of patients take oral glucose-lowering drugs as directed, while adherence drops to 43% to 54% for injectable GLP-1 medications and 41% to 64% for insulin.   Poor adherence can lead to serious consequences. One retrospective study cited in the review found that patients who consistently took their glucose-lowering medications had a 31% lower risk of hospitalization or emergency department visits.   The review also highlighted ways to improve adherence. Simplifying medication routines can help, such as using fixed-dose combination pills, which combine multiple drugs into a single tablet. Studies show these combinations are linked to better adherence and improved blood sugar control.   Pharmacists can also play an important role by providing education, reviewing medications, setting up reminders, and helping patients organize their treatment plans. The researchers noted that support should be tailored to each patient. Older adults may benefit from simpler systems and caregiver support, while younger patients may respond better to digital tools like app-based reminders.   The authors also found that measuring adherence is challenging and recommend using multiple methods, such as pharmacy records, patient interviews, and objective tests when possible.   Overall, the review concludes that personalized, multi-step approaches lasting at least three months are most effective in helping people with type 2 diabetes stay on track with their medications. https://www.pharmacytimes.com/view/type-2-diabetes-medication-adherence-rates-remain-low-and-pharmacists-can-help XX New clinical trial shows metformin does not directly reverse insulin resistance in people with type 1 diabetes. Instead, it lowers the total amount of insulin required to keep blood glucose levels within the recommended range. The findings, published in Nature Communications, challenge long-held assumptions about how metformin works in type 1 diabetes. The results may help physicians refine treatment strategies and reduce the daily demands placed on people who rely solely on insulin therapy. "Insulin resistance is a growing problem in type 1 diabetes. Not only does it make regulating blood sugar levels difficult, but it is an underappreciated risk factor for heart disease, which is one of the biggest causes of health complications and deaths in those with type 1 diabetes," says Dr. Jennifer Snaith, endocrinologist and co-lead of the study.   https://scitechdaily.com/groundbreaking-trial-reveals-unexpected-benefit-of-metformin-in-type-1-diabetes/   Tech news ahead, including updates from Sensonics, Dexcom & Tandem.. right after this…. Back ot the wnews.. XX Sensonics shares that it's secured FDA investigational device exemption (IDE) for its self-powered, battery-enabled Gemini sensor. It enrolled the first patients in the IDE trial and expects to complete that in the second half of 2026. Gemini builds on the implanted CGM to put the transmitter under the skin as well as the sensor. https://www.drugdeliverybusiness.com/senseonics-q4-2025-ide-gemini-cgm/ XX Medtronic Diabetes is now officially MiniMid, a stand alone public company. Medtronic  acquired MiniMed 25 years ago announed last May that it would spin its diabetes business off. In their statement the company points out that MiniMed is the only diabetes tech company to sell both insulin pumps and continuous glucose monitors.   https://www.investing.com/news/stock-market-news/medtronics-diabetes-unit-minimed-valued-at-53-billion-as-shares-fall-in-nasdaq-debut-4547518 XX Kevin Sayer heads back to Dexcom.. The former CEO is back in his position as executive chair of the Board, he'd stepped away for a medical leave. Dexcom (Nasdaq:DXCM) announced today in an SEC filing that former CEO Kevin Sayer has returned from his leave of absence. Sayer's return to the board comes just days after Dexcom announced a new board member. Last week, the company announced that it added Google SVP, Platforms and Devices, Rick Osterloh, to its board as well.     https://www.drugdeliverybusiness.com/kevin-sayer-returns-dexcom-board-chair/ SAN DIEGO - DexCom, Inc. (NASDAQ:DXCM) announced the appointment of Rick Osterloh to its Board of Directors, effective today, according to a press release statement.   Osterloh serves as Senior Vice President, Platforms & Devices at Google, where he oversees Android, Google Play, Chrome, and Google's hardware portfolio including Pixel phones, Google Nest devices, and Fitbit wearables. He has held this position since 2016.   https://www.investing.com/news/company-news/dexcom-appoints-google-executive-rick-osterloh-to-board-93CH-4529662 XX Sequel Med Tech announced broad national availability of its twiist™ Automated Insulin Delivery (AID) System powered by Tidepool. After U.S. FDA clearance in 2024 and a controlled launch to optimize the twiist experience, the system is now fully available nationwide. The release says: Built on Sequel's proprietary iiSure™ Technology, the system enables earlier detection of delivery issues, alerting users to blockages up to nine times faster than other AID systems1, potentially reducing the risk of unexplained high glucose and giving you time to take action before experiencing severe high blood sugar or DKA2. Designed to expand access to automated insulin delivery, twiist is available through pharmacy channels with a flexible access model, XX Tandem Diabetes Care's Mobi automated insulin delivery system is now available with Android devices. In November, Tandem announced that it received FDA approval for the Android version of its Mobi mobile app. The pump, which pairs with Tandem's Control-IQ+ algorithm, previously worked with iOS software. At the time of the clearance, it said it would commence a limited rollout before the full launch — now underway — this year.   Tandem launched Mobi in the U.S. in February 2024. It initially received FDA clearance for people with diabetes ages six and up in July 2023. The system then received expanded clearance for pediatric indications in April 2024, then later won CE mark in May 2025.   Mobi features a 200-unit insulin cartridge and an on-pump button to provide an alternative to phone control for insulin boluses. It comes in at less than half the size of the flagship Tandem pump system, the t:slim X2 pump. Mobi can fit in a coin pocket, clip to clothing or go on the body with an adhesive sleeve. https://www.drugdeliverybusiness.com/tandem-diabetes-care-launches-mobi-android/

In this episode, Doug Larson sits down with Coach Travis Mash and Dr. Mike Lane to challenge the "one-size-fits-all" approach to supplement dosing. They break down why most labels are effectively written for an average-sized person, and why that matters when you're 100 pounds soaking wet, or a 300-pound lineman. Using real stories (like a 450 mg caffeine pre-workout for a small athlete and the classic "I couldn't sleep" aftermath), the crew lays out a simple north star: doses should  scale with body weight, and you should take an amount specific to your body size. From there, they get practical on what works, what's overhyped, and how to time things. Dr. Lane explains beta-alanine as an intramuscular buffer (via carnosine) that helps athletes push harder in the anaerobic "pain cave," but only if it's taken consistently for weeks, not as a one-off. They compare that to sodium bicarbonate as a more acute strategy that can help performance but comes with GI risk if you don't practice it ahead of time. Along the way, they call out a common industry trap: under-dosed formulas, proprietary blends, and products that sound impressive but contain amounts too small to matter. They wrap by narrowing down the essentials: creatine as a daily staple for most people (and potentially higher doses for cognitive benefits, especially under sleep deprivation), plus basics like protein and targeted use of supplements based on training demands. The conversation also goes deep on magnesium, why many people are likely low, how it supports relaxation and recovery, and why the form matters (bisglycinate/threonate etc). The big takeaway: match the supplement to the goal, match the dose to the body, and build your plan on quality ingredients, effective amounts and repeatable habits. Links: Doug Larson on InstagramCoach Travis Mash on Instagram

In this episode, David Watumull breaks down the science behind astaxanthin — a powerful carotenoid antioxidant backed by over 4,000 peer-reviewed papers and 100+ human clinical trials — and explains why it may be one of the most underappreciated longevity compounds available today. The conversation explores how astaxanthin anchors across cellular membranes to protect mitochondria from oxidative stress, reduce chronic inflammation ("inflammaging"), support cardiovascular health by lowering oxidized LDL and CRP, and cross the blood-brain barrier to enhance cognitive function and neuroprotection. They also discuss its role in energy production, endurance performance, healthy aging, and a landmark NIH lifespan study showing a 12% extension in mammals. Ultimately, the episode reframes longevity not as chasing stimulants or shortcuts, but as protecting cellular integrity so the body can function the way it was designed to — for longer and at a higher level. ----- 00:00 – The Longevity Molecule You've Never Heard Of 02:45 – What Is Astaxanthin? 07:30 – How It Protects Your Cell Membranes 13:40 – Free Radicals & Oxidative Stress Explained 25:50 – Brain Health, Neuroplasticity & Mitochondria 29:40 – Cardiovascular Disease & Oxidized LDL 34:05 – Alzheimer's, MCI & Neuroprotection 43:00 – Energy Production & Mitochondrial Function 58:40 – Inflammaging & Longevity Pathways 1:03:40 – NIH Study: 12% Lifespan Extension 1:09:00 – Athletic Performance & Endurance 1:15:00 – Dosing, Absorption & Bioavailability 1:26:00 – Can Antioxidants Become Harmful? 1:30:00 – Why Isn't This Mainstream? 1:37:30 – Living Ever Forward ----- Episode resources: Save 20% with checkout code EVERFORWARD at https://www.AX3.Life.com Watch and subscribe on YouTube Learn more at https://ax3.life/pages/science 

18-year-olds wake up fresh because their repair system still works. This episode shows you how stem cell decline quietly drives fatigue, inflammation, and faster aging, and how fasting can reactivate your body's natural ability to repair itself without expensive stem cell procedures. Grab a generous 30% discount on any STEMREGEN product with: http://stemregen.co/dave30 Dave Asprey sits down with Christian Drapeau, a neuroscientist trained at McGill University and a leading researcher in stem cell science. Christian pioneered a therapeutic approach called Endogenous Stem Cell Mobilization, authored the bestselling book Cracking the Stem Cell Code, and developed the concept of stem cell enhancement. He is the Founder and CSO of STEMREGEN, where his work focuses on helping the body release and use its own stem cells more effectively. Together, they break down why many injected stem cells never survive long enough to help, how the lungs trap a large percentage of IV stem cells, and why releasing your own stem cells into arterial circulation changes the outcome. They explore stem cell decline as a core driver of aging, tissue degeneration, and chronic inflammation, and explain why fasting is currently the only intervention shown to rejuvenate stem cells through autophagy. You'll hear why a three-day fast has measurable effects on bone marrow aging, how stem cells act as signaling molecules that coordinate repair across the body, and why mitochondria play a massive and underappreciated role in stem cell renewal and tissue regeneration. The conversation also covers scar tissue, fibrosis, recovery from injury, and why healing quality matters just as much as healing speed. You'll Learn: • Why stem cell decline, not simple wear and tear, drives aging • How fasting supports stem cell rejuvenation through autophagy • Why many injected stem cells die in the lungs before helping tissue • How releasing your own stem cells differs from IV stem cell therapy • Why mitochondria are central to stem cell function and repair • How scar tissue and fibrosis form when repair fails • Why recovery quality determines long-term resilience and longevity Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. • Generation Lab | Go to http://generationlab.com/, use code DAVE20 for $20 off, and see what your body's really doing behind the surface. • Puori | Use code DAVE at https://puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: stem cell longevity, fasting stem cell rejuvenation, three day fast science, biohacking stem cells, endogenous stem cell mobilization, stem cell decline aging, autophagy fasting longevity, mitochondria stem cells, tissue repair aging, inflammation and aging science, functional medicine longevity podcast, human performance longevity, anti-aging fasting protocol, metabolism and aging, ketosis fasting science, supplements longevity debate, Dave Asprey longevity, Christian Drapeau stem cells, biohacking podcast longevity Resources: • Learn More About Everything STEMREGEN at: http://stemregen.co/dave30 • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 — Trailer 1:20 — Stem Cell Basics & IV vs Release 7:41 — Bone Marrow Conversion & Fasting 11:01 — Stem Cell Decline vs Exhaustion 12:39 — Releasing Stem Cells 14:01 — Stem Cells as Signaling Molecules 18:13 — Stacking Interventions 23:31 — Dosing & Duration 40:42 — Daily Repair & Deficits 48:20 — Resilience & Testing 53:17 — Inflammation as Signal 57:45 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.