Podcasts about Dosing

Curious whether peptide therapy is the missing piece in your wellness routine, or just another overhyped trend? This episode breaks down what these powerful chemical messengers do in the body, from healing injuries to balancing brain chemistry, cellular energy and more, plus why sourcing and dosing make all the difference.Host Jenn Trepeck sits down with Dr. Aleksandra Gajer to explore BPC 157, brain-supporting peptides, and mitochondrial function, while tackling how to use peptides safely, who should avoid them, and why they work best as a tool rather than a magic fix-all.What You Will Learn in This Episode:✅ How peptide therapy acts as a chemical messenger system that supports the body's own healing pathways rather than overriding them✅ Why BPC 157 has become one of the most talked about peptides for tendon repair, gut healing, and recovery✅ How neuroinflammation, not just neurotransmitter imbalance, may be driving anxiety, depression, and brain fog✅ The role of mitochondrial function and insulin sensitivity in body composition, energy, and long-term metabolic healthThe Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Dr. Aleksandra Gajer's path from emergency medicine to proactive, personalized healthcare08:04 Defining peptides and their relationship to inflammation and healing10:04 Exploring BPC 157 for tendon injury, gut healing, and tissue recovery12:31 How peptides support autoimmune conditions by regulating immune balance15:35 Brain peptides Selank and Semax and the truth behind the neuroinflammation link to anxiety18:57 Understanding mitochondrial function, fatigue, and brain fog as cellular energy issues20:35 MOTS-c, insulin sensitivity, and the connection to body composition22:18 Why peptides work best as a tool, not a replacement for healthy habits26:03 Safe peptide sourcing, endotoxins, and who should avoid peptide therapy33:54 Hormone health, dosing strategy, and cycling peptides for sustainable resultsKEY TAKEAWAYS:

In this episode, we explore how the future of wellness is shifting away from endless optimization and toward a more personalized, less-is-more approach to health. We share our current favorite biohacks, discuss the benefits of an alcohol-free lifestyle, cycle syncing, peptides, and emerging technologies like the Ohm Lamp and stem cell therapies. We also unpack the growing backlash against "over-optimization" and why the next era of biohacking will prioritize precision, simplicity, and long-term resilience. Tune in for an inspiring conversation about aging well, supporting future generations, and why 2026 may be the most exciting time yet to take charge of your health.SHOW NOTES:0:40 Welcome to the podcast!2:15 Lauren's favorite biohack right now5:50 Foundational travel hacks6:40 Renee's rescue8:52 Renee's favorite biohack right now9:58 Benefits of no alcohol11:48 PhaseApp for cycle syncing15:31 The Ohm Lamp17:05 Revisiting peptides18:49 Comparison to microdosing23:29 RFK & new regulations24:43 Solving the problem of aging29:35 Excitement for the future of health32:15 Stem cells34:45 Supporting the senior population37:17 The era of ‘less' supplements44:35 Backlash trend of “over-optimization” 49:03 Major/minor signs on OURA50:33 Wellness centers53:26 Final advice & recap55:32 Thanks for tuning in!RESOURCES:Phase App - code: BIOHACKERBABESOhm Lamp - code: BIOHACKERBABESEllie MD PeptidesPeptide QuizEp 346: Addiction & Peptides with Samantha LanderEp 339: GLP-1 Dosing with Jay CampbellBiolongevity Labs - Discount code: BIOHACKERBABESEp 331: GP1 Biology & Calacurb with Sarah KennedyCalocurb - Discount code: RENEE10Dr. Vincent GiampapaBeam Minerals - Discount code: BIOHACKERBABES for 20% offKion Essential Amino Acids - Discount code: BIOBABES for 15% offEp 349: Airway Health & Snoring with Dr. Gene SambataroSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksBPC-157 is the peptide almost everyone starts with. In this masterclass I walk through why, and where the hype gets ahead of the evidence.We have about 30 years of animal studies on this one. We have fewer than 30 human subjects in published research. I keep that line clear the whole way through.I cover what BPC actually does. It helps the body repair tissue. It works on the gut, tendons, ligaments, and even the brain in animal models. It is not a steroid and it does not build muscle on its own. I explain how it works, who it helps, and who should skip it.Then we get practical. Dosing tiers, how to reconstitute the vial, how to inject near an injury, and how long before you feel anything.I tackle the cancer question head on. The fear is plausible on paper. The data does not really back it up. I tell you exactly where I land.We also cover cycling, the Wolverine stack with TB-500, oral versus injectable, and the FDA shift happening right now.Even if you already know this one, you will probably pick up something. If you are new to peptides, start here.

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, fiber, and realistic nutrition habits are essential for preserving muscle and maintaining results. The conversation expands into GLP-1 benefits beyond weight loss, including cardiovascular protection, inflammation, autoimmune flares, addiction-related behaviors, alcohol cravings, libido, menstrual cycles, PCOS, sleep apnea, and what to expect when stopping the medication. Dr. Christle Guevarra Do is a physician focused on obesity medicine, GLP-1 education, weight management, and sustainable lifestyle change. Drawing from both her clinical experience and her own long-term use of GLP-1 medication, she helps patients understand how these medications fit into the bigger picture of long-term health. Her approach emphasizes individualized care, strength training, nutrition, behavior change, and realistic maintenance strategies rather than quick fixes. In this episode, she shares practical guidance for using GLP-1s responsibly while protecting muscle, managing hunger, and building habits that support lasting results. Dr. Christle Guevarra Website https://www.drchristle.com/ Dr. Christle's Free GLP-1 Guide https://www.drchristle.com/glp1-guide Dr. Christle Instagram https://www.instagram.com/dr.christle/ Ozempic — semaglutide https://www.ozempic.com/ Wegovy — semaglutide for weight management https://www.wegovy.com/ Mounjaro — tirzepatide https://mounjaro.lilly.com/ Zepbound — tirzepatide for weight management / sleep apnea https://zepbound.lilly.com/ FDA: Concerns With Unapproved GLP-1 Drugs https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss Retatrutide Clinical Trial Info https://clinicaltrials.gov/study/NCT05882045 Vyvanse — lisdexamfetamine https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Creatine — NIH Supplement Info https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Psyllium Husk / Fiber — MedlinePlus https://medlineplus.gov/druginfo/meds/a601104.html Berberine — NCCIH https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know Tesamorelin — MedlinePlus https://medlineplus.gov/druginfo/meds/a611035.html CJC-1295 — PubMed Research https://pubmed.ncbi.nlm.nih.gov/16352683/ Ipamorelin — PubMed Research https://pubmed.ncbi.nlm.nih.gov/9849822/ FDA: Peptides / Compounding Safety Concerns https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Oura Ring https://ouraring.com/ White Claw https://www.whiteclaw.com/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Weekly Dosing Debate 03:41 Starting Dose Basics 06:28 Pens vs Vials Safety 08:37 Finding Your Sweet Spot 11:01 Nighttime Binge Window 13:32 Lifestyle Work Still Matters 14:30 Benefits Beyond Weight 17:27 Libido and Low Calories 22:26 Alcohol Hits Different 24:59 Cancer Claims Reality Check 26:59 Strength Training Priority 29:06 Supplements and Creatine 29:38 Creatine Protein Fiber Basics 31:50 Berberine Pros and Cons 32:37 Peptides Sleep and Muscle 35:28 Too Lean for GLP-1 38:52 Cycles PCOS and Fertility 40:45 Food Noise vs Appetite 44:42 Staying On or Stopping 49:19 Heart Rate and HRV Concerns 51:38 Ozempic vs Mounjaro Choices 54:45 Sleep Apnea and Wrap Up The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

What Really Happens Inside an Obesity Clinic GLP-1 medications are everywhere right now. Patients are asking about Ozempic, Wegovy, Zepbound, compounded medications, muscle loss, “Ozempic face,” insurance denials, and what happens when the weight loss slows down.But what does obesity medicine actually look like inside the clinic? In this episode, I'm joined by Joseph Zucchi, PA-C, clinical supervisor and physician associate at Transition Medical Weight Loss in Salem, New Hampshire. This is not your typical GLP-1 conversation. We're going beyond protein goals, nausea tips, and constipation management to talk about what clinicians are really facing in practice: how to dose these medications, when to switch, and how to support patients when insurance coverage disappears.In this episode, you'll learn:What to assess when a patient hits a weight loss plateau beyond simply increasing the dose  How to talk with patients about GLP-1 concerns like muscle loss, thyroid cancer warnings, GI side effects, and “Ozempic face”  Why obesity medications are tools, not “cheating,” and how to address weight stigma in the exam room  What clinicians should know about compounded GLP-1 medications and why FDA-approval matters  How to document for prior authorizations and what insurance companies are often looking for  What happens when patients lose GLP-1 coverage and how to discuss alternative medication options  What Joe is most excited about in the future of obesity medicine, including new medications and expanding coverage If you prescribe GLP-1 medications, counsel patients on weight management, or feel overwhelmed by the insurance and documentation side of obesity medicine, this episode will give you a practical, behind-the-scenes look at what comprehensive obesity care can look like.Connect with JoeResources mentioned:Obesity Medicine Nutrition Course (with a 2026 medication update) Use code POD15 for 15% off!155 | Unstuck: Strategies for Sustainable Weight Loss151 | Are GLP-1s Masking Undiagnosed Eating Disorders?Obesity Medication InfographicAny Questions? Send Me a MessageSupport the showConnect with Colleen:InstagramLinkedInSign up for my FREE Newsletter - Nutrition hot-topics delivered to your inbox each week.Disclaimer: This podcast is a collection of ideas, strategies, and opinions of the author(s). Its goal is to provide useful information on each of the topics shared within. It is not intended to provide medical, health, or professional consultation or to diagnosis-specific weight or feeding challenges. The author(s) advises the reader to always consult with appropriate health, medical, and professional consultants for support for individual children and family situations. The author(s) do not take responsibility for the personal or other risks, loss, or liability incurred as a direct or indirect consequence of the application or use of information provided. All opinions stated in this podcast are my own and do not reflect the opinions of my employer. 

Most men think erectile dysfunction is a bedroom problem and low testosterone is just a fact of getting older. This roundtable makes the case that both are early warning lights for your heart, your metabolism, and your long-term health and that ignoring them can cost you a decade.In this episode, Dr. Gabrielle Lyon sits down with urologists and men's health specialists Dr. Mohit Khera, Dr. Larry Lipshultz, and Dr. Tobias Köhler to discuss:Why a 35-year-old with ED carries a ~15% risk of heart attack or stroke within 7 years, ~3.5x the risk of depression, and ~30% odds of diabetes or prediabetes and why a prescription alone misses all of itWhy "age-related" testosterone decline is largely a misnomer: a healthy man shouldn't drop significantly with age, so falling T usually signals something reversible underneathHow testosterone became the single best blood marker of a man's overall health, and the case for annual screening that almost no man getsWhat the TRAVERSE trial changed when the FDA removed testosterone's cardiovascular warning in 2025, debunking the prostate-cancer and heart-attack fearsThe 2-minute monthly self-exam every man should do to catch testicular cancer early, when it's ~99% curableIf you've been told your symptoms are "just aging" or you love a man who refuses to see a doctor. This conversation shows you how to read the signals your body gives long before a crisis hits.Thank you to our sponsors:Body Health - Use the code LYON20 to get 20% off your first order https://bit.ly/4efgBuMTimeline - Get 20% off your Mitopure order at https://bit.ly/49LSbYzBranch Basics - Save 15% at https://bit.ly/4uuw4x3 with code DRLYONExplore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Larry Lipshultz at:Instagram: https://www.instagram.com/lipshultzmd?igsh=NTc4MTIwNjQ2YQ==Website: https://www.larrylipshultz.com/YouTube: https://www.youtube.com/@DrsAmyandLarryFind Dr. Tobias KohlerInstagram: https://www.instagram.com/tobiaskohlermd?igsh=NTc4MTIwNjQ2YQ==X: https://x.com/sexhealthmd?s=11Find Dr. Mohit KheraInstagram: https://www.instagram.com/drmohitkhera?igsh=NTc4MTIwNjQ2YQ%3D%3DX: https://x.com/DrMohitKheraWebsite: https://drmohitkhera.com/Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 - Introduction01:30 - What doctors got wrong about testosterone05:05 - The prostate cancer myth, debunked07:12 - The best marker of a man's health11:51 - Is age-related decline actually real?14:15 - How obesity crushes testosterone18:11 - Testosterone and reversing diabetes20:06 - GLP-1 versus testosterone25:20 - What "low testosterone" really means29:05 - Dosing, CAG repeats, and microdosing42:34 - The TRAVERSE trial and FDA reversal47:10 - The prostate saturation point56:49 - Peptides, explained01:03:00 - Why ED is a check engine light01:08:26 - The desert of men's health care01:11:06 - The case for annual screening01:16:45 - Varicoceles and male fertility01:20:03 - How to check for testicular cancer01:26:44 - Final advice for menIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

In this episode: Mark creates DOSsier, a system for retro PC gaming. Martin replaces his editor (again), this time with Fresh Alan creates a new app for event attendance. You can send your feedback via show@linuxmatters.sh or the Contact Form. If you’d like to hang out with other listeners and share your feedback with the community, you can join us on: The Linux Matters Chatters on Telegram. The Linux Matters Subreddit. If you enjoy the show, please consider supporting us.

In this episode: Mark creates DOSsier, a system for retro PC gaming. Martin replaces his editor (again), this time with Fresh Alan creates a new app for event attendance. You can send your feedback via show@linuxmatters.sh or the Contact Form. If you’d like to hang out with other listeners and share your feedback with the community, you can join us on: The Linux Matters Chatters on Telegram. The Linux Matters Subreddit. If you enjoy the show, please consider supporting us.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksKPV is the most underrated peptide out there. Almost nobody talks about it. In my opinion it should be one of the most demanded peptides we have. If I had to choose, I'd take it over BPC and TB-500 every single time.Here's why. KPV is a tiny three amino acid fragment of alpha-MSH. It directly blocks NF-kappa B, the master switch your body uses to turn inflammation on. Most peptides work around the edges. KPV shuts the alarm off at the door.In this one I cover all of it. What KPV is and how it works. Who actually benefits. Dosing by tier and by purpose. How to stack it with BPC, TB-500, LL-37, and your GLP-1. What to track on bloodwork. Cycling, sequencing, troubleshooting, and a full FAQ.If you've ever run a protocol that worked and then stalled out, this one is for you. Inflammation is almost always the rate-limiting step in healing.Make sure you're on the email list. And come join us in the Axion Collective for live coaching every Thursday.⚠️ For research and entertainment purposes only. ⚠️

Red light therapy is now at Target. It's on Amazon by the thousands. And with that explosion comes a mountain of marketing claims, spec sheet arguments, and consumer confusion that has Freddie and Scott Kennedy — founder of Light Path LED and one of the most science-grounded voices in photobiomodulation — more motivated than ever to cut through the noise. In this fifth conversation across seven years together, they break down exactly what happens at the cellular level when red and near-infrared light hits your body: how cytochrome C oxidase absorbs photons, why that turbine in your mitochondria spins faster, how nitric oxide release drives vasodilation and blood flow, and why the gap between 700 and 800 nanometers is essentially a dead zone. They also get real about power, irradiance, pulsing frequencies, and why the best panel in the world won't save a business model built on charging $100 a session for red light alone. The second half of this episode is a full product walkthrough of what Scott has been building — including the new Titan, a six-foot full-body panel with an electric adjustable stand designed to deliver what $60,000 red light beds do at a fraction of the cost, and the TLC dork cap — three years in development, covering the full head, jaw, cervical lymph nodes, and occipital region with red, near-infrared, and blue light at 10 and 40Hz pulsing. Freddie and Scott also explore the torch, intranasal red light delivery, dental and gum applications, stacking red light with peptides for injection site activation, and the honest conversation about what a sustainable red light business model actually looks like in 2026. Use code BEAUTIFULLYBROKEN at lightpathled.com for a discount.   Episode Highlights   [00:00] – Red light therapy goes mainstream and why consumer confusion is exploding [02:10] – Scott's dental laser background and how he discovered photobiomodulation [04:32] – Why red light supports the body instead of directly “treating” conditions [06:22] – How light increases ATP, blood flow, oxygenation, and downstream cellular benefits [10:00] – The difference between red light and near infrared light [12:11] – What happens at the cellular level with mitochondria, cytochrome C oxidase, and nitric oxide [18:45] – Why irradiance and power claims can be misleading for consumers [24:32] – Therapeutic dose, joules, timing, and why more is not always better [30:53] – The problem with too many wavelengths and marketing-based panel design [36:05] – Lightpath LED's wavelength choices, pulsing features, and near infrared focus [44:11] – The Titan panel and why Scott designed a simpler full-body red light option [45:51] – The Dork Cap, blue blockers, torch attachments, and practical red light tools for daily use   Upgrade Your Health   LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken   MaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKEN Code: beautifullybroken   The Biological Blueprint Course: https://www.beautifullybroken.world/biological-blueprint Earn 200 in BitCoin + Change your health   BEAM Minerals: http://beamminerals.com/beautifullybroken Code: BEAUTIFULLYBROKEN   Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN   StemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52 Code: beautifullybroken CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)What if the reason so many people struggle on GLP-1 medications isn't the medication itself — but the way it's being dosed?Today we're diving into something that could genuinely change the way you think about GLP-1 therapy: custom dosing. And there is honestly no one better to talk about this with than Dr. Ian Justl Ellis.Dr. Ian is a board-certified physician, certified personal fitness instructor, and the creator of the MyLevel GLP-1 Precision Dosing Engine. He's also the founder and CEO of VOA Fit, where he provides highly personalized concierge care through advanced GLP-1 therapy, hormone optimization, and peptide protocols — all paired with real-world fitness and nutrition strategies. Before transitioning into obesity medicine, he spent a decade in emergency medicine.What makes his perspective especially valuable is how he bridges clinical expertise with lived experience in weight management. His work doesn't just focus on prescribing GLP-1s, but on optimizing how they're actually used in real-world patients. And that's exactly what this conversation is about — how dosing strategy can completely change outcomes.Topics discussed:Why GLP-1 results may depend more on dosing than the medication itselfDr. Ian's early belief in discipline — and why it eventually broke downWhen personal struggle turned into a medical reframe of obesityThe first experience with GLP-1s and the reality behind the resultsWhy “dose” isn't the full story — understanding GLP-1 drug levelsMoving from standard protocols to individualized GLP-1 levelingHow personalized GLP-1 dosing works in real patientsThe future of GLP-1 therapy: a more responsive, guided model of careRethinking weight loss: from fixed doses to adaptive biologyThere's a lot more nuance to GLP-1 therapy than standard protocols tend to show, and this episode really breaks down what happens when dosing becomes personalized rather than fixed.So if you want to understand how this approach actually works in practice — and why it might completely shift how we think about weight management — tune in to the full episode.Connect with Dr. Ian:Website: voafit.com,Instagram: voafitmdLearn about MyLevel:  voafit.com/mylevelBook a Consult: go.voafit.comMeet Our Clinic: voafit.comConnect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com

Deb 00:00:01Imagine your body has a repair manual, instructions written in your cells that tell tissues how to heal, blood vessels, how to grow, and inflammation when to stop. But what if those instructions got lost somewhere along the way? Well, today I’m talking about peptides, tiny protein fragments that act like biological text messages. Two of them, BPC 157 and TB 500.They’re showing remarkable promise for gut repair, joint recovery, and tissue regeneration. But here’s what nobody’s telling you. Women respond differently to these healing signals, especially during hormonal transitions. And today, we’re uncovering the science behind these regenerative peptides, who actually needs them, and why your doctor might not know about them. Can you guys put our ad right in here and then I’ll go to the standard intro?Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb, your medical detective. And today we’re diving into regenerative peptides BPC157 and TB 500. If you or someone you love is struggling with slow recovery from injury, chronic joint pain, gut inflammation that just won’t quit, or you just feel like your body doesn’t bounce back the way it used to, this episode is for you. Grab a cup of coffee or tea or whatever helps you unwind, settle in, and let’s start you on your journey to deeper healing. We’ll do another sponsor break here. Deb 00:01:52So let’s start with the question I hear constantly in my practice. Dr. Deb, I’m doing everything right. I’m eating clean, I’m exercising, I’m taking my supplements, but I’m still not healing. What am I missing? Well, that answer might surprise you. Sometimes it’s not about what you’re putting in your body. It’s about whether your cells are actually receiving the repair signals they need. That’s where peptides come in. Think of peptides as The body’s original communication system. These short chains of amino acids are like biological post-it notes carrying instructions from one cell to another. They tell your human system when to calm down, your blood vessels when to grow and your tissues when to repair. Now here’s where it gets interesting for women specifically. We know that estrogen plays a massive role in collagen production, vascular health, inflammatory response. When estrogen starts declining, whether that’s perimenopause, postpartum, or even from chronic stress, our natural repair mechanisms slow down dramatically. You might notice it as my joints are aching more, I’m a little more fluid filled, you know, they hurt when I bend them, my injuries take twice as long to heal.Gut issues that suddenly appear out of nowhere and no matter what you do, they don’t seem to repair. Skin has lost its elasticity or just this general sense that your body isn’t keeping up anymore. This is where BPC 157 and TB 500 entered the picture. So BPC 157, short for body protection compound 157, is a naturally occurring peptide sequence found in your gastric juices. And according to a 2024 systemic review published in emerging use of BPC 157 in orthopedic sports medicine, this peptide promotes something called angiogenesis. That’s the formation of new blood vessels and they deliver oxygen and nutrients to damaged tissues. Now TB 500 is a synthetic fragment of thymus and beta-4. Deb 00:04:17A protein your body makes naturally during wound healing and research published in therapeutic peptides in orthopedics in 2025 shows that it works like a cellular first responder rushing to injury sites and coordinating tissue repair through a process called actin regulation. But here’s what makes these peptides different from just taking another supplement. They don’t force your body to do anything.They simply remind yourselves how to heal the way they used to. And for women navigating hormonal changes, autoimmune flares, chronic inflammatory conditions, that distinction matters enormously. all right, let’s get into some of these mechanisms because understanding how something works helps you make informed decisions about whether or not it’s right for you. So,Let’s look at the science. Do these peptides actually work? And if so, how do they work? Let’s start with BPC 157. This works through multiple pathways simultaneously. First, it activates growth factor receptors that stimulate fibroblasts. Those are the cells responsible for making collagen and rebuilding connective tissue. And according to research published in Frontiers and Pharmacology in 2023, titled Regeneration or Risk, BPC 157 also modulates nitric oxide signaling, which enhances vascular repair and reduces oxidative stress at the cellular level. So this is really important because many of us are nitric oxide deficient, especially as we get older, especially since the pandemic, we’re seeing a lot of people being more deficient in nitric oxide and you’re taking nitric oxide, many of you, to help with this process. But if we’re having other issues that don’t allow that nitric oxide to get where it needs to go, that could render it completely useless. So in plain English, when we’re talking about how BPC 157 helps the blood vessels work better and protects your mitochondria, big word for your energy factories and your cells from that inflammatory damage. Deb 00:06:38Now there’s studies in musculoskeletal and gastroenterology models that show BPC157 decreases inflammatory cytokines like TNF-alpha and IL-6. And these are chemical messengers that keep inflammation turned on. So by dialing them down, BPC157 creates an environment where healing can actually happen. Now, where do we know about this?TNFL and IL-6, well, we know it from viruses, we know it from Lyme disease, we know it from mold toxicity. These cytokines are turned up, they’re creating a massive inflammatory response in the body, and you’re struggling to get these things down because of that or potentially other reasons. So here’s where it gets really interesting with women in perimenopause or menopause. When estrogen declines, collagen synthesis slows down. And that’s why we see increased joint pain, slower wound healing, and our changes in the skin’s elasticity during this transition. We see the little wrinkles, the fine lines, we see the subcutaneous fat going away a little bit more. This is partially why this is occurring. And so from research shown in the Journal of Orthopedic Research in 2023 by Leibowitz and colleagues, that they suggest that BPC157 affects on the endothelial layers. So the cells lining the blood vessels and these may mimic some of the estrogen’s protective vascular effects without actually affecting your hormone levels. This is really huge because we know that as women lose estrogen, they have a higher risk for vascular events, heart attack, stroke, things like that. And if people have already had a heart attack or a stroke, We typically recommend that they don’t use estrogen because that could potentiate the risk for another heart attack or a stroke. But that means that you don’t gain the benefits of estrogen either. So if we think about this, we could potentially use BPC 157 to give us some of the benefits that we lost from having estrogen and potentially not being able to use estrogen. And that would be huge for us. Deb 00:08:57And not to mention the reduction of inflammation and the joint pain and the wound healing and the energy and the gut feelings. I mean, there’s just so many benefits to BPC 157 that we could talk about them all day long. But we’ve got to move on. So let’s talk about TB 500. Now this peptide works very differently. Its primary job is promoting cell migration, essentially telling repair cells to go to this spot and what to do when they get there. So it sends a signal, puts a little post-it stamp there and says, Hey, when you get there, fix A, B, C, and D. And there was a study in 2024 in cell biology international that demonstrated that TB 500 increases epithelial closure and improves tendon elasticity in models of repetitive strain injury. So let’s think about that a little bit. What does that really mean?That means faster recovery from exercise induced muscle damage, better healing of overuse injuries like tennis elbow or plantar fasciitis, improved scar tissue remodeling after surgery or a C-section, enhanced recovery from chronic inflammatory conditions affecting soft tissues. And I’ve talked about this several times. I have used these compounds post-surgical personally.And I remember going back to see my surgeon at the two to three week mark for follow-up. And she was amazed at how well everything was healing. And when I asked her if she wanted to know what I was doing, her response was no, but keep doing whatever you’re doing because it’s working. And after three weeks of a major pelvic repair surgery that I had, four hours in surgery, lots of sutures, not comfortable. I was actually walking a mile and didn’t have pain and I was recovering really well and felt amazing. And that is just not typically heard of in surgical procedures like mine. It’s usually a minimum of a six to eight week recovery before you’re starting to do that again. And I give all of the credit to these two peptides. Deb 00:11:17In my clinical practice, I see this play out constantly. Women who train hard, whether that’s CrossFit, running, yoga, or just trying to keep up with active kids, often hit a wall where their recovery can’t keep up pace with their activity level. And TB 500 helps to bridge that gap by optimizing the body’s natural repair timeline. But here’s what I want to emphasize with you. These peptides aren’t magic bullets.They work best when we combine them with proper nutrition and anti-inflammatory diet, adequate sleep, stress management, and we address the underlying root cause like the gut dysfunction or those hormonal imbalances. And they work much better when the hormones are balanced versus when they’re not. They’re amplifiers of your body’s existing healing capacity, not replacements for foundational health practices.So let’s have some real talk here. Let’s talk about evidence and what you need to know about that. Let’s take a drink, sorry. Now let’s address the elephant in the room. Regulatory status and safety. Neither BPC 157 or TB 500 are FDA approved for human medical use. They fall into a category called research compounds. And that means they’re legal to possess and use but they’re not approved as pharmaceutical drugs. And hopefully they will be back on our list of things to use relatively soon with the changes that Bobby Kennedy has made to peptides recently. So why does this matter? Because quality becomes a concern. Quality control is absolutely critical. You need to know where these compounds are manufactured, their source, their testing. their clarity, everything about them. There was a 2025 review in therapeutic peptides in orthopedics that concluded both peptides demonstrate strong regenerative signaling with minimal systemic side effects in preclinical studies. But, and this is really important, most of the robust data we have comes from animal models and cell culture models, not large scale human clinical trials. Deb 00:13:41Now that doesn’t mean that they don’t work. It just means that we are still in the early stages of understanding optimal dosing, treatment duration, and long-term effects in humans. So why do we have all of this great peptide information and we don’t quite have the ability to use them yet, or it’s extremely restricted?That comes under the guise of the FDA. came through the past administration with Biden where he removed a bunch of these peptides from the market. Both BPC and TB 500 were on the list of safe peptides to use before Biden made his changes. And it looks like they may be coming back relatively quickly for us here. So what we do have is growing clinical feedback from practitioners like myself. Who use these peptides in practice under careful supervision and under pilot studies on musculoskeletal recovery published in our organizations that we work with. So all of our information is documented and it is done under an observational study. There are other studies published in orthopedic and biomedical research from 2025.that actually found VPC-157 reduced pain scores by 35 % and improved functional mobility within eight weeks. This is really phenomenal because many people over the age of 40 are reaching for the Tylenol bottle, the Advil bottle, the Aleve bottle, which does a number on your kidneys and your gut and your liver. And it is really problematic to be using these things on a regular basis.And if we can use a compound that’s safe, that preserves the kidneys, the liver and the gut, why don’t we do that is the question that I have. Now, we see a lot of the same information in our clinic that we see in these studies. And it is the following things that we see. Significant reduction in joint pain and stiffness. I have a person that was looking at doing a knee replacement and we did 10 weeks of these two compounds. Deb 00:16:00And her knee pain reduced so much that she decided she didn’t feel like she needed that knee replacement right away, which is good because she is only 60 years old. And the length of that knee replacement wouldn’t be as long as it would if she could wait five or 10 years. The doctor didn’t say she needed to do it right away. She wasn’t that critical, but it was the pain that was driving her to the replacement. And so if we could preserve that and give her a reduction in pain, all the better to do that. We get faster recovery from surgical procedures, improved gut symptoms, especially in cases of leaky gut or inflammatory bowel conditions, better skin quality and wound healing, enhanced overall sense of resilience and recovery capacity. But here’s what you absolutely must know before considering peptide therapy. First, source matters. Because these aren’t FDA regulated pharmaceuticals, quality varies widely and you need to work with a physician who sources from compounding pharmacies 503A or 503B that provide certificates of analysis, third party testing and proper sterility verification. Secondly, context matters. Peptides work best as part of a comprehensive functional medicine approach. So if you’re still eating inflammatory foods, drinking alcohol, not managing your stress or your sleep, you have unaddressed gut dysfunction, and these peptides alone won’t fix those problems. Thirdly, realistic expectations matter. These aren’t overnight miracle cures. Most patients see gradual improvements over four to 12 weeks. Some respond dramatically, others see modest benefits. Individual variation is real. And fourth, medical supervision matters. Dosing, injection technique,monitoring for side effects and knowing when peptides are or are not appropriate. All of this requires clinical expertise. Now let me bust a few myths here because I hear this constantly. Myth number one, peptides are just for bodybuilders and athletes. That is false. While athletes use them for performance recovery, the therapeutic applications for chronic pain, gut healing and age related tissue decline are profound. Deb 00:18:26For everyday people. Myth number two, peptides will mess with my hormones. False. BPC-157 and TB-500 don’t interact with your endocrine system the way hormones do. They work through growth factors and cell signaling pathways. They are very different. Myth number three, if they’re not FDA approved, they must be dangerous. Not accurate.Many effective therapies exist in regulatory gray zones. What matters is quality sourcing, proper medical oversight, and informed consent. So the bottom line here is that these peptides show real promise backed by mechanistic science and growing clinical expertise, but they require responsible use, quality products, and realistic expectations. Now let’s talk about practical integration.Who should consider peptides? Well, so who actually benefits from the peptides? Let’s start there. Let me walk you through the three main categories I see. Number one is gut restoration. If you’re dealing with chronic gut inflammation, whether that’s IBS, inflammatory bowel disease, leaky gut, persistent digestive issues that haven’t responded to dietary changes alone, BPC 157 can be transformative.I had a patient recently, I’ll call her Sarah. She’s been struggling with severe gut pain and food sensitivities for three years. She tried elimination diets, probiotics, gut healing supplements, everything. And within six weeks of adding BPC 157 to her protocol, alongside the targeted nutritional therapy, her pain dropped by 70 % and she could tolerate foods that she hadn’t tolerated in years. Why does this happen? because BPC 157 directly supports mucosal integrity, the protective lining of your intestinal tract, and it reduces inflammatory cytokines and promotes healing of damaged tissue. Number two, muscle and joint recovery. This is where I see TB 500 shine. Women who are active, whether you’re a runner, a yogi, a cross-bitter, or someone who just wants to keep moving without pain. Deb 00:20:48They often hit a point where recovery becomes a very limiting factor. And maybe you’re dealing with chronic tendonitis, a nagging shoulder injury, a bad back that just will not quit, or just general achiness. It all makes you feel older and keeps you from being active the way you want to. TB 500 combined with therapies like red light therapy, PEMF, or targeted physical therapy, can dramatically accelerate soft tissue healing. I’ve seen recovery timelines cut in half for patients dealing with overuse injuries. Number three, menopausal transition support. This is where the intersection of peptides in women’s health gets really exciting. During perimenopause and menopause, declining estrogen affects collagen production, vascular health, and joint integrity, along with inflammatory processes and responses.Many women notice they just don’t heal as quickly and their joints hurt much more. Besides noticing their skin changes and their injuries linger longer. Low dose peptide protocols, often combining BPC157 for vascular and gut support with TB500 for soft tissue repair, can complement bioidentical hormone therapy or stand alone for women who can’t or don’t want to use hormones.Now I’m not saying that peptides replace your hormone optimization, but they can be powerful adjuncts that support tissue resilience during a time when your body’s natural repair mechanisms are shifting. Now, who should not use peptides? If you have any active cancer or a history of certain cancers, peptides that promote cell growth and angiogenesis might not be appropriate. If you’re pregnant or breastfeeding, we don’t have safety data.If you have severe kidney or liver disease, clearance and metabolism could be affected. You want to work with a practitioner who really understands this and be under medical supervision for these kinds of conditions. This really matters. A qualified functional medicine practitioner can assess your individual situation, run appropriate labs and determine whether peptides fit into your overall healing strategy. Remember, peptides are tools. They’re not magic. Deb 00:23:11They work best when you’re also addressing nutrition, sleep, stress, movement, and underlying root causes. They amplify your body’s healing capacity. They don’t replace the fundamentals. This is really important to understand. So thank you for joining me today on Let’s Talk Wellness Now. If this episode resonated with you, share it with another woman who’s ready to reclaim her body’s natural healing capacity. Remember, Wellness isn’t just about feeling good. It’s about thriving in every area of your life. Your body was designed to heal. You’re not a small version of a male. You are a woman with different biochemistry. And sometimes it just needs the right signals and the right support to remember how. If you’re ready to explore personalized regenerative medicine or peptide therapy as part of a comprehensive functional medicine approach,You can visit us at serenityhealthcarecenter.com. You can also follow us on Instagram, and you can look at my book, Seen at Last, and join the Seen at Last free community on Facebook, where we will provide all of this information and more for you. Until next time, I’m Dr. Deb, reminding you to take care of your body, mind, and spirit. Be well, and I’ll see you in the next episode.The post Episode 269 – Peptide Therapy for Women: How BPC-157 & TB-500 Heal Gut, Joints & Inflammation first appeared on Let's Talk Wellness Now.

With so many supplements marketed to runners, it's easy to wonder what's actually worth taking. In this episode, we cut through the noise and focus on a few supplements that have strong research behind them—while emphasizing that no supplement can replace consistent training, good nutrition, quality sleep, and proper recovery.We break down the Three Cs: Carbohydrates, Creatine, and Caffeine.First, we discuss why many runners are underfueling and how carbohydrates play a critical role in performance, recovery, and endurance. Next, we explore creatine monohydrate, one of the most researched supplements available, and its benefits for strength, recovery, and overall health. Finally, we cover caffeine, including how it can improve performance, common dosing guidelines, and why personal tolerance matters.We also briefly touch on vitamin D, magnesium, omega-3s, and collagen, and discuss when they may be worth considering.In This Episode:Why supplements should never replace the fundamentalsHow carbohydrates support performance and recoveryThe benefits of creatine for runnersHow caffeine can enhance enduranceWhen other supplements may be helpfulAvoiding the optimization trap and keeping things simple03:53 The Three Cs 09:59 Fueling During Runs14:29 Carb Targets And Gut Training20:16 Women Over 40 And Carbs25:03 Adjusting Fuel To Effort28:31 Creatine Explained41:14 Monohydrate and Daily Dose43:25 Caffeine Performance Basics46:23 Dosing and GI Timing47:33 Metabolism and Jitters50:29 Sleep and Tolerance Tradeoffs54:12 Race Day Caffeine Rules56:54 Vitamin D Testing59:34 Magnesium for Cramps01:03:38 Omega 3 Benefits01:05:26 Collagen Versus ProteinGain access to my new secret podcast, Unbreakable: The Runner's Guide To Injury-Proofing Your Body After 40. Click here: https://www.realliferunners.com/secretJoin the Team! -->  https://www.realliferunners.com/team Thanks for Listening!!Be sure to hit FOLLOW on Apple Podcasts, Spotify, or your favorite podcast player Leave a review on Apple Podcasts. Your ratings and reviews really help and we read each one!Come find us on Instagram and say hi! Don't forget: The information on this website is not intended to treat or diagnose any medical condition or to provide medical advice. It is intended for general education in the areas of health and wellness. All information contained in this site is intended to be educational in nature. Nothing should be considered medical advice for your specific situation.

This episode discusses the urgency for pharmacists to transition from using Cockcroft-Gault eCrCL to non-race based estimated glomerular filtration rate (eGFR) to improve medication-related decision-making in persons with reduced kidney function.  Listeners will learn how to transition from C-G eCrCL to eGFR adjusted for body surface area to improve medication effectiveness and safety in persons with chronic kidney disease. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksTesamorelin is one of the few peptides I've seen actually move the needle on body composition. So I made a full masterclass on it.This is the user's guide as it stands in 2026. I cover what tesamorelin is, how it works, and the best practices I'd recommend for using it.We get into the growth hormone axis and why a GHRH is different from a GHRP. I break down the clinical data, the 15% visceral fat reduction, the liver fat numbers, and the cognition research almost nobody talks about.Then we get practical. Dosing, timing, fasted injections, and the cycling patterns I actually use. I share why I stay at one milligram instead of two and what the water retention tradeoff looks like at higher doses.I also cover stacking with testosterone and GLP-1s, reconstitution, injection technique, side effects, and the people who should skip this one entirely.I'm honest about the limits too. Some of this evidence is strong and some of it isn't. I tell you which is which.If you're thinking about tesamorelin or already using it, this is everything I'd want you to know.

Send us Fan MailDr. Ian Justl Ellis is the Founder, CEO, and Lead Physician at Voafit. He specializes in helping individuals achieve their optimal physique while maintaining balance in their family, work, and social lives. His approach focuses on creating sustainable, real-world nutrition and exercise habits that can be maintained long-term without obsessive or unhealthy behaviors.Dr. Ellis has spent much of his life addressing what he describes as the "appetite problem." As a teenager determined not to follow the path of out-of-shape adults around him, he immersed himself in athletics, amateur bodybuilding, professional dance, and became a certified personal trainer. Despite achieving the desired outward appearance, he found himself caught in cycles of restriction, bingeing, and frustration.During medical school, marriage, and raising children simultaneously, he experienced significant personal weight gain and burnout, finishing residency sixty pounds overweight. In 2022, he was introduced to GLP-1 weight management medications, which helped address persistent hunger for the first time. However, using them in standard recommended dosing approaches resulted in muscle loss, weakness, and poor nourishment.In response, Dr. Ellis developed a precision-based approach to GLP-1 therapy that combines strength training, protein-first nutrition, hydration, and individualized dosing strategies. He also incorporated advanced peptide therapies to support hormonal optimization, muscle retention, and recovery.Website: Voafit.comUse code FA FOR 40% OFF Athletic greens is a non-negotiable part of my daily routine. With 75 absorbable vitamins and minerals in just one scoop a day, I have increased my energy, improved my immune function and so much more. To get your own AG at 20% off go to www.athleticgreens.com/functionallyautoimmune Order now for a free vitamin D3/K2 supplement and 5 free travel packs!Support the show

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksTB-500 spends way too much time in BPC-157's shadow. I wanted to fix that.This is my full TB-500 masterclass. I go deep on what this peptide actually does, and why it works so differently than BPC even though we lump them together as the Wolverine stack.First I clear up the confusion between TB-500 and thymosin beta-4, because most people have no idea what they're actually buying. Then I break down the mechanism in plain language. Think of TB-500 as the foreman on a job site, moving the right materials to the right injury at the right time.I cover who it's for, who should skip it, and my full dosing tiers from general recovery up to severe injury. We get into cycling, reconstitution, injection technique, and how to stack it with BPC, GHK, and the growth hormone peptides.I also answer the big questions. Is it legal? Will it cause cancer? Will it touch your hormones? Does it grow hair?If you want more from me, get on the email list and check out the Axion Collective. Both links are in my bio.Enjoy this one. I love TB-500.

Most herbal dosing strategies fail during acute infections, not because the herbs are wrong, but because the dosage, frequency, and timing are wrong. In this video, Sajah Popham from the School of Evolutionary Herbalism walks you through the four biggest mistakes herbalists make when treating infections, and how to create protocols that lead to better outcomes. Here's what you'll learn: Why herbal dosing for acute infections is different from chronic care The four most common mistakes people make when taking herbs during illness Why low-dose strategies often fail in the treatment of acute infections Suggested dosage and frequency guidelines for acute herbal protocols Why herbs need time and consistency to build up and be effective How to think about various herb classes as part of your treatment protocol The importance of organ-system specificity and tissue state energetics Why herbs don't work the same way antibiotics do, and how to manage client expectations Treating lingering symptoms  Supportive lifestyle practices that improve recovery outcomes Warning signs that indicate it may be time to seek medical attention   If you want to dive even deeper into this kind of information, you might really like our FREE Vitalist Herbalism Mini-course.  Join the waitlist to get the FREE workshop when it starts on June 15, 2026: http://www.evolutionaryherbalism.com/vitalist-herbalism-mini-course/waitlist/   ———————————— CONNECT WITH SAJAH AND WHITNEY ———————————— To get free in depth mini-courses and videos, visit our blog at:  http://www.evolutionaryherbalism.com   Get daily inspiration and plant wisdom on our Facebook and Instagram channels: http://www.facebook.com/EvolutionaryHerbalism https://www.instagram.com/evolutionary_herbalism/   Be sure to subscribe to our YouTube Channel: https://www.youtube.com/channel/UCyP63opAmcpIAQg1M9ShNSQ   Get a free 5-week course when you buy a copy of the book, Evolutionary Herbalism: https://www.evolutionaryherbalism.com/evolutionary-herbalism-book/   Shop our herbal products:  https://naturasophiaspagyrics.com/   ———————————— ABOUT THE PLANT PATH ———————————— The Plant Path is a window into the world of herbal medicine. With perspectives gleaned from traditional Western herbalism, Ayurveda, Chinese Medicine, Alchemy, Medical Astrology, and traditional cultures from around the world, The Plant Path provides unique insights, skills and strategies for the practice of true holistic herbalism. From clinical to spiritual perspectives, we don't just focus on what herbs are "good for," but rather who they are as intelligent beings, and how we can work with them to heal us physically and consciously evolve.   ———————————— ABOUT SAJAH ———————————— Sajah Popham is the author of Evolutionary Herbalism and the founder of the School of Evolutionary Herbalism, where he trains herbalists in a holistic system of plant medicine that encompasses clinical Western herbalism, medical astrology, Ayurveda, and spagyric alchemy. His mission is to develop a comprehensive approach that balances the science and spirituality of plant medicine, focusing on using plants to heal and rejuvenate the body, clarify the mind, open the heart, and support the development of the soul. This is only achieved through understanding and working with the chemical, energetic, and spiritual properties of the plants. His teachings embody a heartfelt respect, honor and reverence for the vast intelligence of plants in a way that empowers us to look deeper into the nature of our medicines and ourselves. He lives on a homestead in the foothills of Mt. Baker Washington with his wife Whitney where he teaches, consults clients, and prepares spagyric herbal medicines.    ———————————— WANT TO FEATURE US ON YOUR PODCAST? ———————————— If you'd like to interview Sajah or Whitney to be on your podcast, click here to fill out an interview request form. If Whitney is facilitating an interview:   ———————————— ABOUT WHITNEY ———————————— Whitney Popham is an herbal practitioner and the co-founder of The School of Evolutionary Herbalism and Organic Unity. Her calling to plant medicine began from a deep passion for activism and a vision for creating healing and positive change in the world. She has devoted her life to that vision by being a humble vessel for the plants to touch people's lives and bring more healing and beauty into the world.   Through her own health challenges and struggles, she experienced the profound healing gifts of plant medicines and then committed her life to helping others reach vibrant levels of health. She specializes in digestive health in her clinical practice through working with herbal medicine, nutrition and lifestyle coaching. Her true gift is in listening to the plants through intuition and vision, which she uses to help her clients with healing on the emotional, psychological, spiritual, as well as physical levels of health.  

In today's podcast episode, I'm joined once again by thyroid expert and author Paul Robinson for a listener-led thyroid Q&A session. After our first thyroid conversation was so well received, I invited members from my Facebook community to submit their biggest thyroid-related questions, and we covered a wide range of topics surrounding hypothyroidism, Hashimoto's, T3 therapy, reverse T3, thyroid labs, symptoms, body temperature, hormone balance, and more. Some of the questions discussed in this episode include: • Is reverse T3 testing important? • How low is too low for TSH? • Why do some people with Hashimoto's struggle to convert T4 into T3? • What do high thyroglobulin and anti-thyroglobulin antibodies mean? • How can you support better T4 to T3 conversion? • Why do some people worsen on natural desiccated thyroid? • Can T3 dosing schedules change as healing occurs? • Can BHRT change thyroid medication needs? • Is there a connection between hypothyroidism, Hashimoto's, and migraines? • Can you still have hypothyroid symptoms with a “normal” body temperature? • What markers can help identify reverse T3 issues when testing is unavailable? • How can symptoms, pulse, blood pressure, and temperature help guide T3 dosing? This conversation is educational, nuanced, and filled with practical insights for those navigating thyroid symptoms and thyroid treatment. Paul Robinson is the author of: • The Thyroid Patient's Manual • Recovering with T3 • The CT3M Handbook Whether you are newly diagnosed, struggling despite “normal labs,” or wanting a deeper understanding of thyroid physiology and treatment approaches, I hope this conversation helps you feel more informed and empowered. Paul Robinson is a thyroid patient and thyroid patient advocate. Paul wrote 'The CT3M Handbook' as a companion book to 'Recovering with T3' to explain more about raising cortisol levels if needed. And Paul wrote his third book ‘The Thyroid Patient's Manual'. This book covers all types of thyroid medications (T4, T4/T3, NDT, and T3). His newest book "Articles on Hypothyroidism" combines the best of what Paul has discovered on his 35 year thyroid journey. Find out more about Paul here; https://paulrobinsonthyroid.com/ YouTube - @RecoveringwithT3 Instagram - / paulrobinsonthyroid Books; The Thyroid patients manual https://a.co/d/9VwgyLx The CT3M handbook https://a.co/d/iR5Zayv Recovering with T3 https://a.co/d/1035MD3

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You do the work. You train, you sleep, you eat well, you manage stress. And yet your joints still ache, recovery takes longer, and something just feels harder than it used to.I sit down with David Watumull, co-founder and CEO of AX3, to talk about astaxanthin, a naturally occurring antioxidant he has spent his entire career studying, one that most people have never heard of despite having more than 4,000 peer-reviewed papers and 100 human clinical trials behind it.This is not a conversation about the latest wellness trend. It's a deep look at the science of oxidative stress, chronic inflammation, and what actually happens inside your cells when the damage accumulates faster than your body can repair it.What we explore:- Why astaxanthin is categorically different from vitamins C and E, and how it works at every layer of the cell without ever becoming pro-oxidant.- How chronic inflammation starts with oxidative stress upstream, and why blocking it at the source is safer than suppressing the immune response after the fact.- Why this ingredient was one of only five agents in a 20-year NIH-funded program to extend mammalian lifespan by over 10 percent while also showing health span benefits.- How astaxanthin protects joints, muscles, and mitochondrial energy production, and what the data on competitive cyclists actually demonstrates.- What to look for in a supplement, why bioavailability determines whether you absorb anything at all, and how to build astaxanthin into a foundational daily stack.Chapters: 00:00 Intro03:30 Why Astaxanthin Isn't Like Other Antioxidants07:14 The Algae Origins of Astaxanthin11:22 Salmon, the Food Chain, and Nature's Design15:00 From Pharma Research to Supplement18:21 The NIH Longevity Study Explained23:15 mTOR, FOXO3, and the Aging Pathways29:10 Safe Anti-Inflammatory for Joints and Athletes35:15 Brain Protection and the Blood-Brain Barrier38:02 Skin Health and Sun Damage from the Inside45:00 Redox Balance and Liver Protection48:35 Mitochondria, Energy, and Endurance Performance53:00 How to Stack Astaxanthin with Other Supplements57:10 Dosing, Bioavailability, and What Sets AX3 Apart01:07:00 Why David Watumull Went All-In on One IngredientAbout David Watumull:David Watumull is the co-founder and CEO of AX3, a supplement company built on more than two decades of astaxanthin research. He was introduced to the ingredient as a teenager working on algae ponds on the Big Island of Hawaii, and has spent his career advancing its science through pharmaceutical-grade manufacturing, NIH-funded longevity studies, and peer-reviewed cardiovascular research. His work sits at the intersection of rigorous science and practical supplementation, and it shows.Connect with David Watumull:Instagram: https://www.instagram.com/davewatumull–This episode is sponsored by:AX3: Visit ax3.life and use code GABBY for 20% OFF your first orderWebsite: https://www.ax3.lifeInstagram: https://www.instagram.com/ax3.life–The Gabby Reece ShowThis is where I have real conversations with the people I find most worth listening to: scientists, athletes, coaches, parents, and thinkers who are doing the hard work of building a life that holds up over time. No hacks. No quick fixes. Just honest, practical conversations about performance, longevity, relationships, and what it actually takes to show up well at every age.If you are here, you probably already know that health is not a destination. It is how you live. I am glad you are along for it.Connect with Gabby Reece:Instagram: https://www.instagram.com/gabbyreece/TikTok: https://www.tiktok.com/@gabbyreeceofficialWebsite: https://gabriellereece.comPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Hosts: Ed Jones (Owner of Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Impact of Tennessee Hemp Bill, Discussion of Polypharmacy & Deprescribing  with Dr. Curt Dearing [0:00:00] Ed's Media & Product Updates Preview of main topics: Upcoming Tennessee hemp bill and its negative impact on people using hemp for anxiety, pain, and insomnia. Dr. Curt Deering will discuss polypharmacy and deprescribing. Ed's recent appearances on multiple TV outlets (Fox Phoenix & LA, Be Well NY, CBS Detroit). Discussion of testing the AquaTru water filtration system at home as a potential recommendation (microplastics, partial fluoride removal). Mention that peptides are a growing topic; reference to Noel Lawson as go‑to for prescribed peptides [0:10:42]  Tennessee Hemp Bill & Hemp Industry Impact Introduces guest: Dwayne Madden, owner of Hemp House, as a respected local expert. As of July 1 in Tennessee: All Delta‑8 products will no longer be available for in‑state sale. Many THCA products and all vape products will be gone from shops. CBD and Delta‑9 edibles will have caps: Max 15 mg per serving. Max 300 mg per package. Dwayne notes: Heavy users (e.g., serious pain/conditions) will need to consume many servings to reach effective doses. Law doesn't limit how many packages a person can buy, so total milligrams aren't truly stopped—just made inconvenient. Dwayne explains regulatory control moved: From Tennessee Department of Agriculture (2017–2023) To the ABC (Alcoholic Beverage Commission) Board. Key impacts: All products must now go through distributors, similar to alcohol. Distributors collect taxes and sit between producers and retailers. Small operators like Dwayne cannot qualify for distributor licenses , so he must pay a distributor to move product from his own lab to his own stores. Ed frames this as “follow the money trail” and a way to crush competition. In Tennessee after July 1: No in‑state online hemp sales. Banned products (Delta‑8, etc.) not criminalized for possession or use, only for sale. Potential Workaround: Consumers can order from out‑of‑state websites (e.g., North Carolina), receive products in Tennessee Money leaves the local economy, hurting Tennessee businesses. Ed and Dwayne suggest alcohol industry is likely threatened because many people are reducing alcohol use by using hemp products instead  Dwayne notes: Alcohol sales have declined while hemp sales rose. Regulators appear to be protecting alcohol interests via hemp restrictions. [0:17:41] Federal Regulations & State Opt‑Outs Upcoming federal regulations in November: Expected to be similarly “ugly and nasty” for hemp nationwide. States will have an option to opt out of these federal hemp rules. Tennessee's stance: Governor has stated Tennessee will NOT opt out, so federal restrictions will apply here. Other states (e.g., North Carolina) might opt out, keeping their markets more open. Industry response: Advocacy groups Tennessee Growers Coalition and Hemp Law Group monitor legislation and organize pushback. Some supportive legislators exist, but political drive to reverse current law is limited. Dwayne and Ed distinguish: Reasonable regulation (ID checks, lab tests, dosage clarity, education) vs. A “wipeout/control/takeover” by shifting to ABC and forcing distributor reliance. Dwayne: Says credible local shops (Hemp House, Chattanooga peers like BeeGrity, Snapdragon, etc.) already follow high standards. States this law is not about safety but about control and revenue capture, and will hurt small farmers and businesses. [0:25:55] What Consumers Should Do Before Deadline Practical advice: Stock up now on products that will disappear: Delta‑8 gummies (popular for sleep, anxiety, pain). Other higher‑milligram THC/CBD edibles. Flower and vapes. Hemp House is running clearance sales to move remaining inventory. Dosing notes: Many people do well with ½ Delta‑8 gummy for sleep/anxiety/pain. Some need more or less; staff helps tailor doses for goals. Hemp House will close its North Shore/Tremont Street flagship store by July 1 due to expected sales hit. Remaining Hemp House locations: Ringgold Road (East Ridge) near Spring Creek. Ooltewah by Food City on Lee Highway. Hixson Pike near Workout Anytime and Publix. Broader impact: Other Chattanooga hemp businesses have large staffs (some near 100 employees) and will be heavily affected. The industry is described as grassroots, farmer‑driven, and passionately quality‑focused. [0:33:20] Polypharmacy & Deprescribing with Dr. Curt Dearing Ed introduces Dr. Curt Dearing, clinical pharmacist at Nutrition World (30+ years experience). Curt's background: Formerly fully conventional pharmacist; later “veil lifted” as he discovered green pharmacy (nutritional & botanical alternatives). Current mission: Community outreach to medical schools and residency programs Teach about nutritional and natural alternatives not covered in standard curriculums. Traditional training provides almost zero meaningful nutrition or green pharmacy education. Polypharmacy: use of 5 or more prescription medications. Curt notes: Majority of Americans 65+ meet this definition. Average American receives ~17 prescriptions per year (not all concurrent). Consequences: Increased ER visits due to drug side effects. Estimated ~250,000 deaths/year from drug‑induced causes. Curt's role: Specializes in deprescribing: safely reducing or eliminating unnecessary pharmaceuticals and replacing them with effective natural options when possible.  How Curt Works with Patients & Their Doctors Curt provides coaching, not independent prescribing. Creates detailed packets (10–18+ pages) explaining: Why certain drugs may no longer be needed. Evidence for natural alternatives (e.g., supplements, lifestyle changes). Encourages clients to take the packet to their doctor and have an informed discussion. Patients often fear how their doctors will react to attempts to deprescribe. Green Pharmacy Approach (as described by Dr. Curt Dearing) Using nutritional, botanical, and lifestyle-based therapies either instead of or alongside pharmaceuticals. Focusing on root causes and supporting the body's own healing mechanisms, not just pushing lab numbers in a certain direction. Why polypharmacy is a problem: Increases side effects, drug–drug interactions, and emergency room visits. Contributes to cognitive decline, gut problems, and overall worse health. Often leads to the “prescribing cascade”: Drug A causes side effects → a new drug is added for those side effects → more side effects → more drugs, and so on. How Dr. Curt Dearing uses green pharmacy to reduce polypharmacy: Curt creates a comprehensive list of all medications and supplements. Asks: “Why was this started?” and “Is it still needed?” Looks for: Drugs with no clear current indication. Drugs where a natural option can give similar or better benefit with fewer risks. Drugs that can be safely tapered or sometimes stopped outright (always in coordination with the prescriber). Identifies which meds are likely causing the most harm or least benefit. Some drugs require slow, structured tapering (e.g., sleep meds, acid blockers). Others may be candidates for direct discontinuation after medical agreement. Replacing or supporting with natural alternatives ( please note this is not medical advice, this is a discussion of personal examples in collaboration with medical oversight) Cholesterol: Instead of (or in place of some) statin use, Curt uses berberine and bergamot (Berbercol). In Ed's brother's case, his cholesterol numbers improved on green-pharmacy options, matching or exceeding statin outcomes without the same side‑effect burden. Pain & inflammation: Uses curcumin (for most people), and Boswellia when curcumin isn't enough. Gut/acid issues: Long-term proton pump inhibitor (PPI) use (e.g., omeprazole, lansoprazole) is flagged as harmful to gut microbiome and nutrient absorption. Curt builds step-down plans (tapering PPIs) while supporting the gut with natural measures instead of leaving people on a PPI for 30 years. Focus on side benefits, not side effects. Green pharmacy interventions are chosen because they: Address root causes (e.g., metabolic health, inflammation, gut integrity). Often have multiple positive effects (e.g., berberine helping blood sugar and lipids; curcumin helping joints and systemic inflammation). The aim is fewer total drugs, fewer side effects, better overall function. Clients are encouraged to work with their doctor, so deprescribing is: Planned, Monitored, and Integrated with their existing care. Curt and Ed both acknowledge there are situations where “rescue medicine” is necessary: Severe pain where an opioid is appropriate. Acute crises where drugs are needed as a bandage. The green pharmacy view: Use those drugs as short‑term tools, Then remove or reduce them once the immediate crisis passes, While implementing natural strategies to decrease the need for long‑term prescriptions. [0:56:26] Final Segment  At‑home HPV testing for cervical cancer Ed explains HPV is a major driver of cervical cancer Historically, women had to schedule an in‑office visit for cervical screening, which creates barriers (cost, fear, time, discomfort, lack of insurance). He notes there is now an option for at‑home HPV testing for cervical screening. Intended to increase access for women who aren't getting regular screening. Ed strongly approves of this as a valuable preventive tool and encourages women who haven't been tested to consider it. Ed cites new data showing: Microplastics are found in 100% of human stool samples tested in one study. Higher levels of microplastics are now being linked to gallstones. Broader concerns: Everyday plastic exposure (especially with food and drink) means these particles can: Interact with cells, Drive inflammation, Contribute to premature cellular aging and reduced energy. Practical countermeasures he recommends: Avoid heating food in plastic or placing hot food into plastic containers/wrap (e.g., Saran wrap, plastic take‑out containers). Filter drinking water to remove microplastics (he's trialing the AquaTru system at home, which he says removes 100% of microplastics and much of the fluoride). Improve indoor air quality to reduce airborne microplastic exposure. Ed highlights a serious, long‑term job opening at Nutrition World: Not a summer or short‑term job. Best for someone philosophically aligned with healthy eating and the “green pharmacy” approach. Interested candidates should: Go into the store and speak with Scott, Elisha, or Matt and complete an application.  The post Radio Show / Podcast – May 31, 2026 first appeared on Vital Health Radio.

Most of the mushroom supplements you'll find on Amazon are ground-up fruiting bodies or myceliated grain in a capsule. AHCC is something entirely different. It's a patented fermented extract from shiitake mycelia that has been used in over 1,000 cancer clinics worldwide, backed by more than 100 published studies, and studied specifically for its effects on natural killer cells, HPV clearance, autoimmune conditions, and liver disease. I'd never heard of it until Mimi Lindquist introduced me to it. Lindquist is the co-founder of The Medicine alongside her husband, Chase. She started as a clinical dental hygienist in Seattle, where she observed firsthand how oral health mirrors systemic health, and eventually followed a thread from a patient's HPV recovery all the way to a research compound developed at the University of Tokyo in 1986. In this episode, Lindquist explains what AHCC actually is, how its manufacturing process makes it fundamentally different from any other mushroom product on the market, and why the clinical research behind it is unusually robust for a supplement. The mechanism that makes AHCC interesting is that it doesn't just boost the immune system indiscriminately. It modulates it. For healthy individuals with normal NK cell counts, it doesn't artificially raise them. For people dealing with HPV, cancerous tumors, or autoimmune conditions where the immune system needs more information, it does. This adaptogenic quality is why AHCC can support both an overactive immune response (as in autoimmune) and an underactive one (as in immune suppression from chronic illness or aging) without contradicting itself. I pushed back on this in the conversation because AHCC is a processed product that requires industrial manufacturing to produce, which doesn't fit neatly into an ancestral framework. Lindquist's response was honest: if we were living 100 years ago without microplastics, glyphosate in the rain, and the chronic stress loads of modern life, we probably wouldn't need it. But that's not the world we live in, and the thousands of testimonials she's received from people who had tried everything else and found relief with AHCC are hard to dismiss. Dosing is two capsules daily for general immune support, four for conditions like HPV, Lyme, or autoimmune, and six to eight for serious situations like tumors or advanced liver disease. Their product, Immune Intel AHCC, uses 750 milligrams per capsule with nothing else added. About Mimi Lindquist:  Meagan (Mimi) Lindquist is the co-founder of The Medicin, alongside her husband Chase. With her background as a clinical dental hygienist, culinary nutrition guide, and AHCC educator, she has been helping others prevent disease for over 12 years. Now, Mimi has dedicated herself entirely to sharing the benefits of Immune Intel AHCC, a mushroom supplement unlike any other, to as many people as possible. Instagram: https://www.instagram.com/mimi_themedicin/ Website: https://www.themedicin.com Podcast: https://feeds.captivate.fm/themedicin/ [Discount Code] Use code PRIMALSHIFT for 10% off Mimi's products → https://www.themedicin.com Thank you to this episode's sponsor, Peluva! Peluva makes minimalist shoes to support optimal foot, back and joint health. I started wearing Peluvas several months ago, and I haven't worn regular shoes since. I encourage you to consider trading your sneakers or training shoes for a pair of Peluvas, and then watch the health of your feet and lower back improve while reducing your risk of injury.  To learn more about why I love Peluva barefoot shoes, check out my in-depth review: https://michaelkummer.com/health/peluva-review/  And use code MICHAEL to get 10% off your first pair: https://michaelkummer.com/go/peluva  In this episode: 00:00 Intro  04:24 From dental health to holistic  07:47 Oral microbiome and inflammation  11:58 How AHCC entered her life  16:58 What AHCC actually is  19:17 Origins and NK cell research  28:13 Immune modulation explained  30:40 Fungal network intelligence  32:30 Primal vs processed supplements  36:15 Modern stress and immune support  40:10 Dosing for different needs  41:19 Kids and pets success stories  43:13 Industrial consistency vs foraging  47:37 How long until results  56:10 Final thoughts Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code.

Most people think tracking their protein is enough. The science says what your body actually craves is something far more specific and the person making that argument spent 23 years inside legacy media watching the wellness industry sell women everything from "bikini body in two weeks" to canned protein soda. In this episode, I sit down with Liz Plosser, former Editor in Chief of Women's Health, where she oversaw brands reaching 44 million women. We break down why the nine essential amino acids are what your body is really after when you chase protein, why BCAAs are only a fraction of the picture, and why a study found four of the top six creatine gummies on Amazon contained zero creatine. Liz also opens up about her own supplement stack, her shift from endurance running to heavy lifting, and makes the case that testing instead of guessing is one of the most empowering moves you can make for your health. Then we go deep on the science most people get wrong: why aging women struggle to pull amino acids from food, how essential aminos protect lean muscle even on rest days and for those on GLP-1s, the new research on high-dose creatine for sleep deprivation and Alzheimer's, and why collagen may not deserve the hype. We also cover the menopause misinformation epidemic, the 2002 hormone study that terrified the world, and what Liz puts in her own morning protocol. This conversation will completely change how you think about protein, what you supplement, and how you fuel your brain and body. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The Protein Myth and Why Amino Acids Are What Your Body Really Wants 00:56 Protein, Amino Acids, and How Much You Actually Need 03:23 The Nine Essential Amino Acids: The Real Building Blocks 06:03 BCAAs vs EAAs: Why a Subset Isn't Enough 11:50 23 Years in Wellness Media: What Liz Saw Change 14:18 The Menopause Conversation and Why It Exploded 23:17 Kion Aminos, Timing, and Whether It Counts Toward Your 100g 26:46 Liz's Daily Routine: Aminos, Creatine, and the Morning Glass of Water 27:42 Can You Take Aminos While Fasting? 29:50 Do Aminos Preserve Lean Mass on Rest Days and on GLP-1s? 36:19 Leaving Legacy Media and Finding a New Mission 39:14 The New Creatine Research: Sleep, Dosing, and Alzheimer's 43:24 How Creatine Reaches the Brain and the Case for 10 Grams 44:48 Creatine for Mood and Depression 46:12 Collagen: Does It Actually Deserve the Hype? 49:40 The Creatine Gummy Scandal: Four of Six With Zero Creatine 51:27 Coffee, Cans, and Why Bioavailability Matters 54:50 Creatine, Electrolytes, and the 1990s Bodybuilding Hack 57:54 Liz's Morning Protocol and Owning Your AM _______ Thank you to our sponsors Function Health: https://www.functionhealth.com/louisanicola Timeline: https://www.timeline.com/partners/neuro-athletics AirDoctor: https://www.AirDoctorPro.com use promo code NEURO for up to $300 off Qualia Life: https://www.qualialife.com/Neuro for an additional 15% off on top of the 50% BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Most people think tracking their protein is enough. The science says what your body actually craves is something far more specific and the person making that argument spent 23 years inside legacy media watching the wellness industry sell women everything from "bikini body in two weeks" to canned protein soda. In this episode, I sit down with Liz Plosser, former Editor in Chief of Women's Health, where she oversaw brands reaching 44 million women. We break down why the nine essential amino acids are what your body is really after when you chase protein, why BCAAs are only a fraction of the picture, and why a study found four of the top six creatine gummies on Amazon contained zero creatine. Liz also opens up about her own supplement stack, her shift from endurance running to heavy lifting, and makes the case that testing instead of guessing is one of the most empowering moves you can make for your health. Then we go deep on the science most people get wrong: why aging women struggle to pull amino acids from food, how essential aminos protect lean muscle even on rest days and for those on GLP-1s, the new research on high-dose creatine for sleep deprivation and Alzheimer's, and why collagen may not deserve the hype. We also cover the menopause misinformation epidemic, the 2002 hormone study that terrified the world, and what Liz puts in her own morning protocol. This conversation will completely change how you think about protein, what you supplement, and how you fuel your brain and body. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The Protein Myth and Why Amino Acids Are What Your Body Really Wants (00:00:56) Protein, Amino Acids, and How Much You Actually Need (00:03:23) The Nine Essential Amino Acids: The Real Building Blocks (00:06:03) BCAAs vs EAAs: Why a Subset Isn't Enough (00:11:50) 23 Years in Wellness Media: What Liz Saw Change (00:14:18) The Menopause Conversation and Why It Exploded (00:23:17) Kion Aminos, Timing, and Whether It Counts Toward Your 100g (00:26:46) Liz's Daily Routine: Aminos, Creatine, and the Morning Glass of Water (00:27:42) Can You Take Aminos While Fasting? (00:29:50) Do Aminos Preserve Lean Mass on Rest Days and on GLP-1s? (00:36:19) Leaving Legacy Media and Finding a New Mission (00:39:14) The New Creatine Research: Sleep, Dosing, and Alzheimer's (00:43:24) How Creatine Reaches the Brain and the Case for 10 Grams (00:44:48) Creatine for Mood and Depression (00:46:12) Collagen: Does It Actually Deserve the Hype? (00:49:40) The Creatine Gummy Scandal: Four of Six With Zero Creatine (00:51:27) Coffee, Cans, and Why Bioavailability Matters (00:54:50) Creatine, Electrolytes, and the 1990s Bodybuilding Hack (00:57:54) Liz's Morning Protocol and Owning Your AM _______ *Thank you to our sponsors*Function Health: https://www.functionhealth.com/louisanicolaTimeline: https://www.timeline.com/partners/neuro-athleticsAirDoctor: https://www.AirDoctorPro.com use promo code NEURO for up to $300 offQualia Life: https://www.qualialife.com/Neuro for an additional 15% off on top of the 50%BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.in... Learn more about your ad choices. Visit megaphone.fm/adchoices

All links here: ⁠https://hunterwilliamshealth.com/linksSS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?If you're a clinician or just researching for yourself, this is the complete user's guide.For entertainment purposes only.Timestamps00:00 Intro01:00 What this masterclass covers03:18 Why SS-31 matters and what makes it different03:46 FDA approval and the Forzenity brand name04:50 Peptide foundations and how SS-31 is made05:52 The SS-31 sequence and the Seto-Schiller naming origin06:40 Mitochondria 101 and why ATP matters07:28 Mitochondrial dysfunction across chronic disease08:34 Cardiolipin, cristae, and Barth syndrome09:34 Why SS-31 is not a direct antioxidant10:46 How SS-31 actually works (the upstream Godfather effect)11:12 Why no receptor means no desensitization13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)14:24 Who should skip it15:34 The three-tier dosing ladder16:54 The FDA-approved 40mg dose and diminishing returns19:08 Dosing by goal (longevity, performance, recovery, healing)19:48 Cycling logic and the 8-12 week framework20:22 When to dose (morning vs night)21:24 What to expect and when (week-by-week timeline)22:20 Why cycle if it doesn't desensitize24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)26:18 Reconstitution and injection technique28:22 What to track (subjective markers and biomarkers)29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs31:28 Stacking for cognition and visceral fat32:26 Troubleshooting "I don't feel anything"33:54 Injection site reactions34:36 When to discontinue and the first-two-week headache window35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)37:54 Research grade vs pharmaceutical cost difference38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)40:30 Final thoughts and where SS-31 sits in the broader picture42:20 Closing

Send us Fan MailOne infant is diagnosed with neonatal opioid withdrawal syndrome every 27 minutes, and rates are rising. In this episode of Journal Club, Ben and Daphna review the Optimized NOW randomized clinical trial, a landmark multicenter study published in JAMA. The trial compared symptom-based dosing,  a single opioid dose given when a withdrawal threshold is met against the traditional scheduled opioid taper in infants managed with Eat Sleep Console. The results are striking: symptom-based dosing reduced time to medical readiness for discharge by nearly two and a half days, and 65% of pharmacologically treated infants avoided scheduled opioid dosing entirely. Could this be the evidence-based approach that finally reshapes how we treat NOWS pharmacologically?----Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial. Devlin LA et al HEAL Evaluation of Limited Pharmacotherapies for Neonatal Opioid Withdrawal Syndrome (HELP for NOWS) Consortium.JAMA. 2026 Apr 25:e265782. doi: 10.1001/jama.2026.5782. Online ahead of print. PMID: 42033722Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show. Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up. You'll Learn: Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one Thank you to our sponsors! - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity Resources: • Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:37 – Intro 03:57 – Pomegranates 10:03 – Discovering Urolithin A & Mitophagy 20:50 – Science vs. Pomegranate Supplements 25:24 – Topical Skincare Science 26:09 – L'Oreal Partnership & Skin Results 33:38 – 15 Clinical Studies & XPRIZE 43:50 – Nature Aging Immune Study 49:22 – Dosing & Daily Routine 51:29 – Future of Mitochondrial Health See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

All links here: https://hunterwilliamshealth.com/links00:00 — Intro and why I'm doing these masterclasses02:42 — What we're covering and the regulatory timeline04:04 — The two users: weight loss vs longevity05:30 — What Retatrutide actually does (the three receptors)06:50 — Why the glucagon receptor makes Retatrutide different07:54 — Weight loss trial data (1mg to 12mg)10:50 — The longevity data: liver fat, ApoB, blood pressure13:14 — Who the lean biohacker user is13:50 — The titration playbook15:32 — Once weekly vs split dosing19:50 — Morning vs night injections21:02 — How far to push the dose (why 8mg is the ceiling)22:50 — How long to stay on and the regain problem25:44 — Longevity maintenance protocol26:34 — Lean user protocol27:24 — Protein and training are non-negotiable29:06 — Side effects and how to manage them30:20 — The heart rate question and why I use taurine32:00 — The weird skin sensitivity issue33:48 — Pairing Retatrutide with testosterone35:56 — Drug interactions (blood pressure, thyroid, insulin)37:02 — Metrics that matter38:42 — How to cycle off correctly39:54 — The most common mistakes40:42 — How to start, what to do if you plateau43:04 — Should you switch from Tirzepatide?45:28 — Combining Retatrutide with other peptides46:50 — The Ten Commandments of Retatrutide use47:50 — The bottom lineToday's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.Let me know what you think. I plan on doing many more of these on every peptide that matters.⚠️ For research and entertainment purposes only. ⚠️

Dr. Stephanie Estima gives a masterclass on the often-overlooked role of lactate in how our bodies work during exercise. She's redefining lactate as a key metabolic signal that can help us get stronger, age better and think sharper. In this solo episode, Dr. Stephanie gets into how lactate is made, how it fuels our energy and why it's so important when we push ourselves hard. Dr. Stephanie is a big fan of sprinting because it helps us build metabolic power and stay strong, and she'll also talk about how to use it right and how to recover well. Episode Overview: (0:00) Introduction — Lactate Is Not the Enemy (2:15) Welcome & Episode Roadmap (4:30) The Myth: How We Got Lactate Wrong (7:00) What Lactate Actually Is (The Biochemistry) (9:30) Why Lactate Forms Even With Oxygen (15:00) The Gear Analogy — Don't Be Metabolically Polite (18:00) Metabolic Flexibility & Why HIIT Matters (22:00) How to Dose Your Sprints (Beginner to Advanced) (24:30) The Lactate Shuttle — Redistribution, Not Waste (28:30) Mitochondrial Biogenesis & Longevity Signals (32:00) Lactate and Your Brain — BDNF, Fog & Cognitive Edge (38:30) Dosing, Recovery Rules & Programming (46:00) Closing — You Are Remodelling Yourself Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep469 We couldn't do it without our sponsors: BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. MUSE - Train your nervous system with feedback, the same way you'd train muscles with resistance. If you are ready to unlock your brain's potential, go to https://choosemuse.com/BETTER or use code BETTER at checkout to get started. PIQUE LIFE - If you want to redefine your afternoon and evening rituals and still feel like yourself the next day, you can get 10% off at https://piquelife.com/better TIMELINE   - Timeline's clinically proven formula is now available at a new, lower price . Mitopure now starts at $79, when you go to https://timelinenutrition.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Blood Sweat & Gear dives into TRT, Trestolone, carb loads, GH testing, Masteron & estrogen, Melanotan 2, cutting strategies, and real coaching insight from experienced bodybuilding coaches. We break down physique critiques, off-season nutrition, health support supplements, and what really matters for progress on cycle and in prep. Featuring Scott McNally and the crew discussing bodybuilding, PEDs, coaching, contest prep, and the science behind getting bigger, leaner, and healthier. 0:00 Intro & Listener Questions 1:00 Trestolone (MENT) as TRT Instead of Testosterone? 4:30 How Top Coaches Use High Days in a Diet 9:00 How to Calculate the Perfect Carb Load 11:45 The Most Important Part of Great Coaching 15:30 Using High Days During the Off Season 19:30 Do Taller Bodybuilders Need More Gear? 24:30 Should You Test GH Labs While Using Growth Hormone? 28:50 300 Test + 300 Masteron — Estimating Estrogen Levels 35:00 Sending PED Samples to Janoshik Explained 36:30 Melanotan 2 Protocols, Dosing & Results 40:45 Should There Be a Coaching Review Website? 44:30 Best Training Tips While Cutting Calories 50:10 Do You Need Health Supplements During a Cruise? 56:00 Live Physique Critique & Feedback 1:03:45 Behind the Schedule & Podcast Talk 1:05:30 Why Everything at Think Big Is Eccentric 1:07:00 Ms. Olympia Joins the Chat 1:10:40 Scott McNally's Client Competing in Germany

Diagnosis, workup, and the four-step treatment protocol for thyroid storm. Hosts: Annaliese Elam, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Thyroid_Storm.mp3 Download Leave a Comment Tags: Critica Care, Endocrine, Thyroid Storm Show Notes I. Pathophysiology & Diagnosis Definition: Life-threatening hypermetabolic state resulting from decompensated thyrotoxicosis. Hormonal Profile: Absolute levels of total T₄/T₃ often mirror uncomplicated thyrotoxicosis; storm is driven by rapid rate of rise, increased catecholamine sensitivity, or increased free T₄/T₃ concentrations. Clinical Presentation: Hyperpyrexia (e.g., 104.2°F) Tachycardia/Arrhythmias (e.g., 155 bpm) Altered Mentation: Agitation, delirium, or psychosis; often the primary differentiator between “storm” and “compensated” hyperthyroidism Warm, moist skin Precipitating Events: Infection, trauma, or surgery Parturition Abrupt cessation of antithyroid medications Burch-Wartofsky Point Scale (BWPS): ≥ 45: Highly suggestive of Thyroid Storm 25–44: Suggestive of impending storm < 25: Storm unlikely Note: High sensitivity but low specificity; can be skewed by unrelated febrile illness. II. Laboratory & Ancillary Findings Thyroid Panel: Characteristically low TSH with elevated free T₄ and T₃. Metabolic Abnormalities: Mild hyperglycemia (catecholamine-induced insulin inhibition) Mild hypercalcemia Elevated LFTs and leukocytosis Cardiovascular: EKG may show sinus tachycardia or atrial fibrillation with rapid ventricular response. III. Management: The Four-Step Blocking Strategy Step 1: Sympathetic Blockade (Beta Blockers) Agent of Choice: Propranolol Mechanism: Non-selective blockade; in high doses, inhibits peripheral conversion of T₄ to T₃. Dosing: PO: 60–80 mg every 4–6 hours IV: 0.5–1 mg over 10 minutes Critical Pitfall: Avoid in patients with acute decompensated heart failure with systolic dysfunction; risk of cardiovascular collapse. Step 2: Inhibition of Hormone Synthesis (Thionamides) Agent of Choice: Propylthiouracil (PTU) preferred over Methimazole in life-threatening storm. Mechanism: Blocks synthesis of new hormone and inhibits peripheral T₄-to-T₃ conversion (decreases T₃ by ~45% in 24 hours). Dosing: 200–250 mg PO every 4 hours Step 3: Inhibition of Hormone Release (Iodine) Agents: Potassium iodide (SSKI) or Lugol’s solution Critical Timing: Must wait at least 60 minutes AFTER thionamide administration. Rationale: Immediate iodine administration provides substrate for new hormone synthesis (Wolff-Chaikoff effect bypass), potentially worsening thyrotoxicosis. Step 4: Inhibition of Peripheral Conversion & Adrenal Support Agent: Glucocorticoids (Hydrocortisone) Mechanism: Inhibits peripheral T₄ to T₃ conversion and treats potential relative adrenal insufficiency. Dosing: 300 mg IV loading dose, followed by 100 mg IV every 8 hours IV. Supportive Care & Avoidance Measures Hyperpyrexia Management: Acetaminophen is the standard of care Avoid Aspirin: Salicylates displace thyroid hormone from thyroid-binding globulin (TBG), increasing free T₄/T₃ levels Volume Resuscitation: Aggressive IV fluids; patients are often profoundly dehydrated May require 3–5 liters of isotonic crystalloid per 24 hours Take Home Points I. Diagnostic Essentials Clinical Diagnosis: Based on hyperpyrexia, cardiovascular dysfunction, and altered mentation. Key Differentiator: Altered mentation (agitation, delirium, psychosis) is often the sole finding distinguishing “storm” from “compensated” thyrotoxicosis. Burch-Wartofsky Point Scale (BWPS): ≥ 45: Highly suggestive of storm. 25–44: Suggests impending storm. < 25: Storm unlikely. Note: High sensitivity, low specificity (e.g., hyperthyroid + flu can score > 45). Triggers: Infection, trauma, parturition, or abrupt cessation of antithyroid drugs. II. The Four-Step Blocking Strategy Beta Blockade (Propranolol): Dose: 60–80 mg PO q4–6h or 0.5–1 mg IV over 10 min. Action: Blocks symptoms and inhibits peripheral T4 to T3 conversion. Caution: Avoid in acute decompensated heart failure with systolic dysfunction. Thionamides (PTU): Dose: 200 to 250 mg every four hours. (note: some resources suggest a loading dose beforehand) Action: Preferred over methimazole; blocks new hormone synthesis and peripheral T4 to T3 conversion. Iodine (SSKI/Lugol’s): Timing: Must wait ≥ 60 minutes AFTER thionamide dose. Action: Blocks hormone release. Pitfall: Early iodine provides substrate for new hormone synthesis, worsening the condition. Glucocorticoids (Hydrocortisone): Dose: 300 mg IV load, then 100 mg IV q8h. Action: Blocks conversion and provides adrenal support. III. Critical Supportive Care Hyperpyrexia: Use Acetaminophen. NEVER Use Aspirin: Displaces thyroid hormone from binding proteins, acutely increasing free T4/T3 levels. Volume: Aggressive fluid resuscitation; patients may require 3–5 L/day due to profound dehydration. Read More

Could GLP-1 medications be the missing piece in treating inflammatory skin disease? In this episode of Science is Skin, Dr. Ted Lain sits down with Dr. Lindsey Bordone — former Columbia University associate professor of dermatology, now in private practice at Bordone Dermatology in Scottsdale, Arizona — for a deep dive into metabolic disease and the skin. Dr. Bordone was among the first dermatologists to prescribe GLP-1 agonists for her patients, and in this conversation she explains exactly why. From the link between hyperinsulinemia and chronic inflammation to the visible skin signs of insulin resistance — skin tags, acanthosis nigricans, forearm hair loss — she makes the case that dermatologists are uniquely positioned to catch metabolic disease before any other specialty. Dr. Bordone walks through how she uses tirzepatide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy), and the emerging triple-G drug retatrutide, including her lab protocols, dosing philosophy, how to manage GI side effects, and the surprising interaction between GLP-1s and estrogen therapy. In this episode: Why high BMI reduces biologic efficacy in psoriasis patients How to check fasting insulin (HOMA-IR) and why most physicians aren't doing it Skin signs of insulin resistance: skin tags, forearm hair loss, and neck skin thickening Tirzepatide vs. semaglutide vs. retatrutide — how to choose and when Retatrutide's remarkable 93% fatty liver clearance rate in clinical trials The truth about sarcopenia and muscle loss on GLP-1 medications Dosing protocols, side effect management, and when NOT to escalate quickly Protein intake recommendations during active weight loss Estrogen and GLP-1 synergy — what dermatologists need to know Lab work to run before and during GLP-1 therapy How to build an insurance case for continued medication coverage Resources mentioned: HOMA-IR fasting insulin/glucose testing AAD resources on metabolic dermatology Bordone Dermatology — Scottsdale, Arizona Enjoyed this episode? Share it with a colleague and leave us a five-star review. Subscribe so you never miss an episode of Science is Skin. To watch this and other episodes, be sure to check out our YouTube page DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.See omnystudio.com/listener for privacy information.

In this high-yield, no-fluff episode, Dennis is joined by Dr. Michael Falk, a pediatric emergency medicine physician, former academic, and combat-experienced relief worker who has run airways in Haiti post-earthquake, Mosul during the ISIS fight, Ukraine, and Gaza. They break down exactly why pediatric airways are a completely different beast in prolonged field care and give you field-proven tactics that actually work when you're the only one there with a BVM and a prayer.Key Takeaways You Can Use TomorrowPositioning is everything: One to two inches under the shoulders (or whole body) prevents automatic obstruction from the massive occiput.Adjuncts > early tube: NPA or OPA + side-lying (gravity is your friend) can keep you from tubing in the field.Tube sizing rule: Child's pinky ≈ ET tube diameter. Depth = 3× tube size. Always go smaller — you can ventilate, you can't un-damage a ripped airway.Intubation mindset: Kid airway is more anterior and cephalad. Slow down, work your way in, or you'll be in the esophagus.GCS decision:

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-483 Overview: Human papilloma virus (HPV) vaccination can prevent most cases of cervical cancers, yet global coverage remains critically low. In this episode, we discuss the latest evidence on single-dose vs. two-dose HPV vaccination regimens, empowering you to counsel patients and families with confidence, address barriers to series completion, and maximize cancer prevention in your adolescent population. Episode resource links: Noninferiority of One HPV Vaccine to Tow Doses.  The New England Journal of Medicine.  2025.  Kreimer AR, Porras C, Liu D, et al. Cancer Prevention and Early Detection Facts and Figures.  American Cancer Society (2025).  2025.  Rick, Alteri, Deana Baptiste, Emily Butler Bell, et al. Guest: Anne Powell, MD   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-483 Overview: Human papilloma virus (HPV) vaccination can prevent most cases of cervical cancers, yet global coverage remains critically low. In this episode, we discuss the latest evidence on single-dose vs. two-dose HPV vaccination regimens, empowering you to counsel patients and families with confidence, address barriers to series completion, and maximize cancer prevention in your adolescent population. Episode resource links: Noninferiority of One HPV Vaccine to Tow Doses.  The New England Journal of Medicine.  2025.  Kreimer AR, Porras C, Liu D, et al. Cancer Prevention and Early Detection Facts and Figures.  American Cancer Society (2025).  2025.  Rick, Alteri, Deana Baptiste, Emily Butler Bell, et al. Guest: Anne Powell, MD   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

In this Herb of the Month episode, I share one of my favorite heart centered nervines, Motherwort. Leonurus cardiaca is an ancient plant with a long history of use for nervousness, heart rhythm support, insomnia, and overall cardiac care.

Editor's Summary by Linda Brubaker, MD, Deputy Editor and Anne Cappola, MD, Senior Editor of JAMA, the Journal of the American Medical Association, for articles published from April 25-May 1, 2026.

In this episode of the Flex Diet Podcast, I sit down with creatine researcher Dr. Darren Candow from the University of Regina to break down what the research actually says about creatine for muscle, performance, and body composition—plus the newer interest in brain health, aging, and longevity. We dig into practical dosing (including higher-dose ideas for bone and brain), why timing probably doesn't matter much, and what the data shows on safety, side effects, and common myths like hair loss. We also talk about creatine in special contexts like sleep deprivation, jet lag, concussion/TBI potential, and vegan or low-creatine diets, along with how caffeine might (or might not) interfere. If you want an evidence-based, real-world guide to creatine, this one's for you. Sponsors: Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 04:00 How Candow Started Creatine 06:10 Glutamine Reality Check 07:17 Top Supplements Today 08:23 NAD Hype vs Evidence 11:36 Creatine Dosing and Timing 15:06 Brain Uptake and Sleep Loss 18:17 Safety Diet and Essentiality 21:49 Harris Studies and Dose Ranges 24:30 Creatine for Concussion Prevention 26:31 High Dose Game Prep 27:12 Creatine Beyond Sports 29:16 Soccer Cognition Hits 31:38 Caffeine Creatine Myth 35:11 Caffeine Dosing Timing 37:32 Creatine Bone Findings 39:22 Bone Research Reality 43:39 Heart Health Potential 44:20 Creatine Forms Hype 46:30 Future Creatine Research 47:51 Wrap Up Resources 48:37 Conference Manual Plug 51:29 Medical Disclaimer Outro Flex Diet Podcasts you may enjoy: Episode 351: Brain Rehab that Works: Tools for Concussions and Migraines with Dr. Ayla Wolf YouTube: https://www.youtube.com/watch?v=DUcFEjpj8mA Episode 318: Could GAA be the Next Creatine with Dr. Guillermo Escalante YouTube: https://www.youtube.com/watch?v=MTlU7RLnEhg Connect with Dr Candow: Instagram: https://www.instagram.com/dr.darrencandow Website: https://creatineforhealth.com/prof-darren-candow-phd Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

In this episode, we explore how pregnancy reshapes the pharmacokinetics of psychiatric medications — and what that means for your patients. Can stopping a mood stabilizer actually put a pregnancy at greater risk than continuing it? Dr. Amanda Koire breaks down the evidence. Faculty: Amanda Koire, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 0.5 CME: Prescribing in Pregnancy: What Every Clinician Should Know Pregnancy's Impact on Medication Efficacy and Dosing Considerations

In this episode of the NCS Podcast Hot Topics series, host Richard Choi, DO, FNCS, is joined by Melissa Dang, PharmD, BCCCP, neurocritical care pharmacist at MedStar Franklin Square Medical Center, to discuss the article "Levetiracetam Dosing Optimization in Neurocritical Care Population: Neuro-ARC Study", recently published in Neurocritical Care. Their conversation explores how augmented renal clearance may reduce levetiracetam exposure in neurocritical care patients and the implications for seizure management in clinical practice. Dr. Dang breaks down the study's pharmacokinetic modeling, highlights key dosing findings and reviews the patient factors most strongly associated with increased drug clearance. She also discusses the study's limitations and emphasizes the need for caution when applying its findings across broader clinical settings. The views expressed on the NCS Podcast are solely those of the hosts and guests and do not necessarily reflect the opinions or official positions of the Neurocritical Care Society.

In this clinically rich episode, host Dr. Ted Lain sits down with board-certified dermatologist and global skin cancer expert Dr. Todd Schlesinger — AAD Board of Directors member, Mohs surgeon, clinical assistant professor at George Washington University School of Medicine, and medical director of the Clinical Research Center of the Carolinas — for a deep dive into systemic and targeted therapies for non-melanoma skin cancer (NMSC). The doctors begin with a thorough breakdown of the hedgehog signaling pathway (PATCHED, Smoothened, GLI-1 transcription) and how mutations in this pathway drive basal cell carcinoma (BCC) growth. They compare the two FDA-approved hedgehog pathway inhibitors (HHIs) — vismodegib (Erivedge) and sonidegib (Odomzo) — covering their mechanisms of action, volume of distribution differences (16–18L vs. ~9,000L), indications for locally advanced and metastatic BCC, how to define "locally advanced," and complete vs. partial response rates. Dosing strategies are addressed in detail, including alternate-day dosing and treatment breaks backed by the MIKIE study and STEVIE safety study. For managing the most common adverse events — muscle cramps, dysgeusia, weight loss, and fatigue — Dr. Schlesinger shares his clinical protocol using L-carnitine supplementation (1,500–2,000mg liquid, started 2–4 weeks before therapy) along with calcium and CoQ10. The conversation then moves to PD-1 and PD-L1 checkpoint inhibitors for locally advanced and metastatic cutaneous squamous cell carcinoma (cSCC) and BCC, covering cemiplimab (Libtayo), pembrolizumab (Keytruda), and nivolumab (Opdivo). The hosts explain the immune checkpoint mechanism using a memorable analogy, discuss how UV exposure upregulates PD-1 on tumor cells, and explore the practical realities of dermatologists prescribing infusion-based immunotherapy — including multidisciplinary care team logistics, buy-and-bill considerations, and when to partner with oncology. The episode closes with an exciting look at the pipeline: intralesional therapies for nodular and superficial BCC from companies including Verica, iViva, PHIO, and Feldan, red light PDT for superficial BCC nearing FDA approval, and the broader question of where these drugs fit as neoadjuvant, adjuvant, or primary therapies — and what complete response benchmarks (80–95%) dermatologists should expect before adopting non-surgical primary options. To watch this and other episodes, be sure to check out our YouTube page DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.See omnystudio.com/listener for privacy information.

What if everything you thought you knew about peptides—and even GLP-1s—was only scratching the surface? In this episode, we sit down with Jay Campbell to unpack the rapidly evolving (and often misunderstood) world of peptide therapy, from regulation challenges and dosing risks to the truth about purity and sourcing. Jay shares what's really happening behind the scenes with major pharmaceutical players, what's coming next with compounds like Retatrutide, and why so many people are getting GLP protocols wrong. The conversation goes beyond hype, diving into how to work with your biology through smarter protein strategies, muscle-building, and personalized optimization. If you're curious about the future of longevity medicine, this episode will completely shift your perspective.Jay Campbell is a health optimization pioneer, longevity and peptide expert, and five-time international bestselling author. He is the co-founder of BioLongevity Labs and has spent more than two decades studying metabolic health, hormone optimization, and aging biology. Jay's work blends cutting-edge science with intuition and self-awareness, helping people understand how to work with their biology rather than override it.SHOW NOTES:0:40 Welcome to the podcast!2:21 About Jay Campbell3:05 Welcome him to the show!3:45 Current regulation of peptides6:35 Challenges with dosing yourself8:35 Big compounders like Eli Lilly9:25 What's on the horizon!10:15 Research companies vs Telehealth12:25 Cheap vs pure peptides19:05 BioLongevity Labs testing20:08 Peptide origin myths!21:17 Coming soon22:53 *APOLLO NEURO*24:54 *CALOCURB*26:47 GLP-3 Retatrutide29:19 The wrong doses of GLPs32:26 GLP-4s, 5s, and 6s36:18 What we got wrong about GLP-1s39:15 Protein goals & building muscle44:39 Adding in Calocurb 46:10 Once/week dosing47:39 Where to find him47:49 Thanks for tuning in!RESOURCES:Apollo Neuro - Discount code: BIOHACKERBABES for $90 off Smart Vibes bundleCalocurb - Discount code: RENEE10Website: Biolongevitylabs.com - Discount code: BIOHACKERBABESInstagram: Jay CampbellInstagram: Biolongevity LabsYouTubeFacebookXBook: Metabolic AwakeningSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Dr. Derek Stitt and Dr. Page B. Pennell discuss antiseizure medication management during pregnancy and postpartum, based on the MONEAD study.  Show citation:  Pennell PB, Li D, Kerr WT, et al. Antiseizure Medication Dosing Strategy During Pregnancy and Early Postpartum in Women With Epilepsy in MONEAD. Neurology. 2026;106(2):e214483. doi:10.1212/WNL.0000000000214483 

Dr. Derek Stitt talks with Dr. Page B. Pennell about antiseizure medication management during pregnancy and postpartum, based on the MONEAD study.  Read the related article in Neurology®.  Disclosures can be found at Neurology.org. 

In this episode, Eric Malzone hangs out with Jim LaValle—a legend in metabolic health who's been deep in this world for over 40 years—for a real conversation about GLP-1s, peptides, and what it actually takes to build a healthier, longer life. Jim gets honest about why these drugs can be a game-changer but also why so many people use them wrong, the sketchy side of the "research only" peptide market, and which peptides he's actually excited about for gut health, hormones, and fixing your sleep. They also talk about why the fitness industry hasn't quite cracked the longevity code yet, and how the whole landscape is shifting thanks to consumer demand, post-COVID wake-up calls, and even AI. It's a no-BS chat that'll make you rethink quick fixes and appreciate the basics again. Key Takeaways

Welcome back to Embody Radio! Today's episode is one of those "nerdy girl deep dives" that I've been so excited to share with you. I sat down with David Watumull, a researcher and formulator who has spent over two decades in the astaxanthin space, starting all the way back in the algae ponds of Kona, Hawaii as a high schooler, and working his way through pharmaceutical-grade research and development.   If you've never heard of astaxanthin, or if you've heard of it but kind of wrote it off as "just another antioxidant," this episode is going to change that for you. We get into the weeds on what makes astaxanthin structurally different from other antioxidants (spoiler: it actually spans the entire cell membrane like a bridge, while things like vitamin C just sit on the outside), how it fights free radicals without becoming a pro-oxidant itself, and why it matters for literally everyone, not just people who are "old enough to worry about aging."   We cover a LOT of ground in this one: What oxidative stress actually is (explained like you're five) and why modern life accelerates it How astaxanthin works upstream of inflammation like a thermostat, not an on/off switch The connection between oxidative stress and brain fog, mood, sleep, joint pain, and skin health Why your 3pm energy crash might be a bigger red flag than you think How astaxanthin crosses the blood-brain barrier and promotes neuroplasticity and BDNF production The NIH Interventions Testing Program results Astaxanthin's role as "internal sunscreen." What that means and what it doesn't Why it pairs so well with omega-3s, creatine, and other longevity supplements Dosing guidance David's personal story from the algae ponds to pharmaceutical research to launching AX3   I've been personally taking astaxanthin for about a month now, and I'm noticing calmer mental energy, better recovery from training, and significantly improved REM and deep sleep. This one is backed by over 4,000 peer-reviewed papers and 100+ human clinical trials, so we're not just vibing here, there's real science.   If you want to try AX3 for yourself, use code EMBODY at ax3.life for a 20% discount. This is one of those foundational supplements I think more of us should be prioritizing.   Fitness, health, and holistic wellness for $22/month Interested in a luxury 1:1 online health coaching experience? Look no further than FENIX ATHLETICA, where we fuse science and soul for life-long transformation (inside AND out). For the high-achieving hot girls that want to recover better, support glowier skin, and promote longevity through better cellular health, get 20% off your first order of Mitopure and make wellness easier than ever. Follow me on Instagram Follow EMBody Radio on Instagram

In this episode, Doug Larson sits down with Coach Travis Mash and Dr. Mike Lane to challenge the "one-size-fits-all" approach to supplement dosing. They break down why most labels are effectively written for an average-sized person, and why that matters when you're 100 pounds soaking wet, or a 300-pound lineman. Using real stories (like a 450 mg caffeine pre-workout for a small athlete and the classic "I couldn't sleep" aftermath), the crew lays out a simple north star: doses should  scale with body weight, and you should take an amount specific to your body size. From there, they get practical on what works, what's overhyped, and how to time things. Dr. Lane explains beta-alanine as an intramuscular buffer (via carnosine) that helps athletes push harder in the anaerobic "pain cave," but only if it's taken consistently for weeks, not as a one-off. They compare that to sodium bicarbonate as a more acute strategy that can help performance but comes with GI risk if you don't practice it ahead of time. Along the way, they call out a common industry trap: under-dosed formulas, proprietary blends, and products that sound impressive but contain amounts too small to matter. They wrap by narrowing down the essentials: creatine as a daily staple for most people (and potentially higher doses for cognitive benefits, especially under sleep deprivation), plus basics like protein and targeted use of supplements based on training demands. The conversation also goes deep on magnesium, why many people are likely low, how it supports relaxation and recovery, and why the form matters (bisglycinate/threonate etc). The big takeaway: match the supplement to the goal, match the dose to the body, and build your plan on quality ingredients, effective amounts and repeatable habits. Links: Doug Larson on InstagramCoach Travis Mash on Instagram