Podcasts about Dosing

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dave walks through why metformin blunts the muscle-building signal your body needs from exercise, why rapamycin's stunning mouse studies fell apart in the 2025 PEARL trial, and why statins help one person in a hundred while draining the CoQ10 your mitochondria depend on. Then he lays out the yes list: tadalafil for vascular and brain health, SGLT2 inhibitors for metabolic and kidney protection, acarbose for gut and longevity markers, and low dose naltrexone for calming an overactive immune system. Host Dave Asprey is the father of biohacking, founder of Danger Coffee and Smarter Not Harder, and a New York Times bestselling author who has spent decades studying human performance, functional medicine, and the science of not aging. As co-founder of Unlimited.Life, a concierge longevity practice that runs over $50,000 in lab work per client, he pulls back the curtain on what the data actually shows once you strip away the marketing. This is essential listening for anyone serious about biohacking, longevity, anti-aging, human performance, brain optimization, and hacking their own biology with real supplements and functional medicine tools instead of guesswork. You'll Learn: Why metformin can cancel out the muscle gains from resistance training and drain your B12 for years What the 2025 PEARL trial actually found when rapamycin was tested in healthy adults Why statins carry a 100-to-1 harm-to-benefit ratio and quietly starve your mitochondria of CoQ10 How tadalafil supports nitric oxide, vascular health, and neuroplasticity at low daily doses Why SGLT2 inhibitors trigger ketosis-like metabolic effects and protect kidney function How acarbose changes gut bacteria and shows some of the strongest longevity data in mouse studies How low dose naltrexone modulates the immune system and reduces neuroinflammation How to talk to your doctor about using these drugs off-label for longevity instead of disease treatment Thank you to our sponsors! - ALP | Go to alppouch.com, code DAVE for 10% off. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kinetic | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - Visit www.myvitalc.com/davesfav to unlock Dave's discount Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Metformin, Rapamycin, Statins, Tadalafil, Cialis, SGLT2 inhibitors, Jardiance, Acarbose, low dose naltrexone, longevity drugs, anti-aging medication, repurposed pharmaceuticals, off-label drugs, mTOR inhibitor, AMPK, autophagy, endothelial dysfunction, CoQ10, insulin resistance, mitochondrial efficiency, senescent cells, nitric oxide, neuroinflammation, vascular health, PEARL trial, Unlimited.Life Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:01 – Intro 03:48 – Metformin 09:18 – Rapamycin 12:55 – Statins 17:28 – Statins & CoQ10 19:38 – Tadalafil 23:43 – SGLT2 Inhibitors 26:12 – Acarbose 28:40 – Low-Dose Naltrexone (LDN) 31:44 – Dosing & Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the key to a more effective detox isn't taking less—but taking the right amount? In this episode of the Health Fix Podcast, Dr. Jannine Krause sits down with Jeff Hoyt, founder of Zeolite Labs, to take a deep dive into zeolite, detoxification, binders, and why the way you dose a binder may dramatically affect how you feel. Jeff explains how natural clinoptilolite zeolite works as a selective "smart binder," the differences between powdered, liquid, nano, and synthetic zeolite, and why quality and particle size matter. He also shares his controversial "dosing paradox"—the idea that, for some people, microdosing zeolite may actually trigger more detox reactions than a higher dose. They also explore detox reactions, nervous system sensitivity, gut health, EMFs, heavy metals, testing, and how supporting the body's overall health may be more important than aggressively targeting a single toxin. In This Episode, You'll Learn: What zeolite is and how it supports detoxification The "swap and drop" mechanism and why zeolite is considered a selective binder Natural vs. liquid, nano, and synthetic zeolite Why purity, particle size, and quality matter The surprising "dosing paradox" and why more may sometimes be better than microdosing Detox reactions, nervous system sensitivity, and how to minimize them Zeolite's potential role in gut health, heavy metals, and EMF sensitivity How to approach testing and support your body's natural detox pathways Key Takeaway Detoxification isn't necessarily about pushing harder or tolerating more symptoms. As Jeff explains, the goal is to support the body's ability to move unwanted compounds out without overwhelming the system in the process. If you're curious about zeolite or have struggled with detox reactions in the past, this conversation offers a deeper look at how binders work—and why the dose, quality, and form of the product matter. Note: This episode discusses information and experiences shared by the guest and is intended for educational purposes. Detox protocols and supplements should be considered in the context of your individual health needs and, when appropriate, with guidance from a qualified healthcare professional. Connect with Jeff Hoyt Jeff Hoyt is a wellness educator and the founder and President of Zeolite Labs LLC . Transitioning from a background running alternative wellness clinics, he now focuses on mineral-based detoxification and is the creator of the dietary supplement ZeoCharge™. As host of The Detox Experience Podcast, Hoyt is best known for pioneering his "Higher Dose Theory," which advocates for unconventional zeolite dosing protocols to help people target heavy metals, mold, and environmental toxicants. https://www.thezeolitecoach.com/ Instagram: @ZeoliteLabs Connect with Dr. Jannine Krause Check out Dr. Krause's Website for more resources and subscribe for more conversations on functional medicine, longevity, brain health, hormones, nutrition, and natural strategies to optimize your health. Be sure to Like, Subscribe, and Share this episode with someone who wants to protect their brain and age with vitality.    

Apply to work with the MI team → https://muscleintelligence.com/apply Ryan Smith co-founded the first pharmacy in the United States to offer an extensive list of peptides — and he ran the synthesis floor himself. Preparative HPLC, mass spec, chemical synthesis, the lot. Which means he spent years watching the same two failures from the inside: the molecule that works beautifully at a small dose and stops working when someone doubles it, and the vial that looks identical to the real thing and isn't. He is not a peptide evangelist. Ask him about the compound he calls ten million times more potent than BDNF and he'll tell you why he doesn't take it. His argument here is quieter than most of what gets said about peptides, and harder to unhear afterward: the body is already a competent system, and nearly everything that goes wrong with these compounds comes from handing it more input than it needed. Why exogenous growth hormone removes a brake the secretagogues leave in place. Why ipamorelin became the standard despite releasing less growth hormone than the compounds it replaced. Why two vials of the same peptide, at the same purity, can behave completely differently. He would rather talk about what he refuses to make than what he's excited about — and by the end of the hour it's clear those are the same conversation. 5 Key Takeaways Why exogenous growth hormone removes a brake your body doesn't get back — and what CJC-1295, ipamorelin and tesamorelin do instead The reason ipamorelin became the clinical standard despite releasing less growth hormone than the compounds it replaced Why the same 500-microgram dose of oral BPC-157 works in one form and barely at all in another Why the peptide he calls 10 million times more potent than BDNF is the one he leaves out of his own stack What a clean HPLC mass spec report still can't tell you about what's in the vial — and why that one blind spot lands on your liver Chapters 0:00 Why Peptides Took a Century to Arrive 4:54 Specificity, Growth Hormone & the Scalpel Argument 16:22 Thymosin Alpha-1, Epitalon & Natural Testosterone 25:25 Mitochondrial Peptides & the Fat Loss Compounds 32:27 BPC-157: Repair, Dosing & the Salt Form Problem 35:46 Peptides for the Brain: FGL, Dihexa & Cerebrolysin 47:05 What He Takes, What He Refuses & Why 52:36 Side Effects, Purity & What's Really in the Vial Connect with Ryan X – https://x.com/ryansmithepiage LinkedIn – https://www.linkedin.com/in/ryan-smith-lexington-ky/ TruDiagnostic – https://www.trudiagnostic.com

In this episode, Dr. Rena Malik is joined by Dr. Rachel Rubin to unpack the complexities of menopause management, hormone therapy, and sexual health. They discuss the major gaps in medical training around menopause, the challenges patients face in getting evidence-based care, and the importance of individualized treatment. Listeners will gain vital insights into hormonal changes, how to advocate for better care, and why sexual health should be considered a key aspect of overall wellness. Become a Member to Receive Exclusive Content: ⁠renamalik.supercast.com⁠ Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 Why Menopause Care Falls Through the Cracks 03:40 The Need for Better Hormone Prescribing 04:24 Menopause, Testosterone, and Quality of Life 07:37 What Happens When Estrogen Drops 10:26 Finding the Right Hormone Toolbox 13:40 Dosing, Absorption, and Hormone Levels 22:05 IUDs, Perimenopause, and Treatment Decisions 23:28 Brain, Heart, and Whole-Body Health 30:41 Changing the Conversation Around Sexual Medicine Let's Connect!: WEBSITE: ⁠http://www.renamalikmd.com⁠ YOUTUBE: ⁠https://www.youtube.com/@RenaMalikMD⁠ INSTAGRAM: ⁠http://www.instagram.com/RenaMalikMD⁠ TWITTER: ⁠http://twitter.com/RenaMalikMD⁠ FACEBOOK: ⁠https://www.facebook.com/RenaMalikMD/⁠ LINKEDIN: ⁠https://www.linkedin.com/in/renadmalik⁠ PINTEREST: ⁠https://www.pinterest.com/renamalikmd/⁠ TIKTOK: ⁠https://www.tiktok.com/RenaMalikMD⁠ ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices

Piracetam, Racetams & Nootropics: Dave Asprey on the Original Smart Drug, Brain Optimization and How to Biohack Memory, Focus and Cognitive Decline We're excited to bring you another Dave solo education masterclass, this one breaking down the molecule that started the entire nootropics industry: Racetams Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey pulls back the curtain on piracetam and the racetam family, the original nootropics that quietly built the foundation for modern human performance and brain optimization. As the father of biohacking and someone who has taken racetams almost every single day for 25 years, Dave brings firsthand experience most experts simply don't have. He built two Bulletproof-era companies and led the biohacking movement while running this stack daily, and in this episode, he shares exactly how it worked for him. Dave traces the strange 1964 Belgian lab discovery that forced scientists to invent the word "nootropic" in the first place, then breaks down how these compounds shift acetylcholine, glutamate, and AMPA signaling to improve memory, focus, and neuroplasticity without touching dopamine or spiking your heart rate. He covers the mitochondria and membrane fluidity mechanisms behind the anti-aging and longevity effects, walks through dosing for all five major racetams, and explains who actually benefits versus who's wasting their money. This is essential listening for anyone serious about biohacking, human performance, functional medicine, and brain optimization. Whether you're stacking supplements for sleep optimization, exploring fasting and ketosis for metabolism, or just trying to think clearer without sacrificing your health, this episode hands you a real framework for hacking cognitive decline before it starts. You'll Learn: Why piracetam forced scientists to invent the term "nootropic" and what actually qualifies as one How racetams change acetylcholine, glutamate, and AMPA signaling without acting like a stimulant The link between racetams, mitochondria, and neuroplasticity, and why it matters for anti-aging Dosing breakdowns for piracetam, aniracetam, oxiracetam, pramiracetam, and phenylpiracetam Who benefits most: aging brains, stroke recovery, athletes, and anyone flying frequently How to stack racetams with choline, Danger Coffee, and other supplements the smarter not harder way The regulatory mess keeping safe, tested nootropics out of reach in the US Thank you to our sponsors! - ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order. - Pique | Head over to Piquelife.com/Dave to get 20% off your order. - OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: piracetam, racetam, nootropics, smart drugs, aniracetam, oxiracetam, pramiracetam, phenylpiracetam, cognitive enhancement, brain optimization, memory improvement, neuroplasticity, mitochondrial function, acetylcholine, glutamate AMPA receptors, choline supplements, CDP-choline citicoline, alpha-GPC, brain fog remedy, stroke recovery cognitive, dementia prevention, biohacking supplements, Dave Asprey nootropics, longevity brain health, focus and concentration, memory recall, cognitive decline aging Resources: • Download Dave's Free Peptide Guide at daveasprey.com/peptide-guide. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:10 – Intro 04:30 – Birth of the Nootropic 08:55 – How Racetams Work 12:51 – Membranes & Blood Flow 15:55 – Piracetam: The Original 19:30 – Aniracetam & Others 22:00 – Phenylpiracetam Power 26:37 – Who Benefits & Stacking 32:25 – Safety & Regulation 36:41 – Starter Protocol & Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Elle Russ chats about some of the biggest misconceptions around thyroid hormone dosing. From T4-only and T4/T3 combinations to NDT, direct T3, slow-release T3, dose splitting, timing, and sublingual dosing, Elle breaks down why there is no one-size-fits-all protocol—and why people often mistakenly apply T3-only dosing rules to completely different thyroid hormone protocols. She also shares her own experience having used T3-only, T4/T3 combinations, and navigating reverse T3 issues over the years. If you've ever wondered whether you need to dose multiple times a day, whether your thyroid medication should be split, or why a dosing strategy that works beautifully for one person makes absolutely no sense for another, this episode clears up the confusion. Learn more about Elle Russ HERE

We are backkk, I have survived the plague and it's time for a big Q&A to get us back in the groove!I hope you enjoy, and don't forget to share and tag me on insta @emma.currivan xoxo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠CHAT TO ME ABOUT COACHING ON WHATSAPP⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠JOIN MY PATREON HERE⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - just 5.99 a month hehe xTo submit a question for a Q&A episode⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠click here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Don't forget to subscribe to my YouTube channel!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Catch you in the next one xoChapters00:00 Emma's birthday and recent travel reflections01:47 Health scare and recovery from food poisoning03:57 Rome trip highlights and food experiences07:02 Review of a viral Rome rooftop bar09:49 Post-travel illness and recovery process13:00 Handling nutrition around major surgery16:06 Growing a coaching business and industry saturation20:05 The importance of personal branding in coaching24:10 Client communication and check-in timing30:06 Advice on nutrition, supplements, and training35:12 Balancing lifestyle and bodybuilding coaching39:58 Reflections on family, personal life, and future plans44:50 Q&A on various fitness and coaching topics

Once-weekly basal insulin therapy has moved from clinical trial data to pharmacy shelves, offering clinicians a new option for patients who struggle with the daily burden of insulin injections. The shift addresses a persistent adherence problem in basal insulin therapy, where missed or inconsistent daily dosing undermines glycemic control.In this episode of Diabetes Dialogue, hosts Diana Isaacs, PharmD, and Natalie Bellini, DNP, discuss the pharmacy launch of insulin icodec (Awiqli), the first once-weekly basal insulin now available in the United States.The approval rests on data from approximately 4200 participants across the phase 2 and phase 3 ONWARDS program. In insulin-naive participants enrolled in ONWARDS 1, 3, and 5, insulin icodec produced superior reductions in hemoglobin A1c compared with once-daily basal insulin. Among participants switching from daily basal therapy in ONWARDS 2, icodec showed noninferior glycemic control alongside improved treatment satisfaction scores.Insulin icodec has also been studied in type 1 diabetes but did not receive approval in this population after trials showed higher rates of hypoglycemia relative to daily basal insulin. Additional studies in type 1 diabetes are ongoing, leaving open the possibility of future expansion beyond the current type 2 indication.Dosing requires new clinical habits, since insulin icodec is formulated as U-700, a concentration allowing a full week's dose to be delivered in a comfortable injection volume. Adjustments occur in 10-unit increments rather than the single-unit changes used with daily basal insulins, though the weekly total still translates into modest day-to-day changes of roughly one to two units. Patients switching from daily basal insulin require a loading dose, calculated by multiplying the total daily dose by 10.5, to reach steady state faster than a standard weekly conversion would allow.Titration follows fasting glucose. Clinicians add 20 units when readings exceed 130 mg/dL, maintain the dose between 80 and 130 mg/dL, and subtract 20 units below 80 mg/dL. Because increases and decreases are dosed in 20-unit blocks, most cycles are reassessed over two to four weeks rather than week to week.The reduced injection frequency carries particular relevance for older adults, caregivers, and patients whose adherence to daily regimens has proven inconsistent. As pharmacy access expands, coverage and prior authorization requirements will shape how quickly insulin icodec moves into routine practice, but early trial and satisfaction data point toward a meaningful shift in basal insulin management.

Emily Werner, PhD, RD, CSSD, IFNCP is Team Dietitian for the Philadelphia 76ers (NBA) and Philadelphia Flyers (NHL), and Nutrition Affairs Sport Lead at Timeline. Dr. Emily joins Dr. Mike to unpack postbiotics, urolithin A, and why mitochondrial health matters for pro athletes and everyday people alike, digging into the real research behind Timeline's Mitopure and why chasing $200K gadgets rarely beats getting the fundamentals right. Expect to learn what a postbiotic actually is and how urolithin A differs from other supplements, why old-school and new-school sports dietitians disagree on peptides and supplement fads, how chronic undereating quietly undermines performance in women's sports, what the current human performance research on urolithin A actually shows, how Mitopure is dosed and why urolithin A can't be reliably food-sourced, and why product quality and manufacturing integrity matter more than marketing claims, and much more. Connect with Emily: Website: https://www.eateliteperform.com/ Instagram: @emilywerner34 LinkedIn: https://www.linkedin.com/in/emily-n-werner-phd-rd-cssd-ifncp-4a820a97/ Episodes you'll enjoy next: #377 — Methylene Blue for Mitochondria & Performance: Benefits, Dosing & Risks with Dr. Scott Sherr: Listen here #382 — Creatine for Muscle, Bone, Brain & Longevity (Plus Caffeine, Dosing, and Safety) with Dr. Darren Candow: Listen here Episode Timestamps: 2:21 Welcome & introductions 6:09 What is a postbiotic? Pre-, pro-, and postbiotics explained 7:09 Urolithin A: the postbiotic behind Mitopure 8:19 How Emily started consulting for Timeline 10:11 Old-school vs. new-school sports dietitians on supplements 13:53 Peptides, anecdata, and why athletes ignore the data 20:05 The hardest lesson: letting go when clients won't listen 21:15 Money, ego, and athletes chasing $200K wellness gadgets 24:53 Chronic undereating in women's sports 30:48 Nutrition's real job: keeping athletes available to play 33:19 Inside Mitopure: Timeline's flagship urolithin A product 35:06 Mitochondria, mitophagy, and why they matter as we age 38:16 Diet, fasting, and exercise as natural mitophagy triggers 43:36 What the performance research on urolithin A actually shows 53:19 Aging, aerobic capacity, and Emily's 101-year-old grandma 55:40 Mitopure dosing: how much urolithin A and when to take it 57:14 Why urolithin A can't be food-sourced (and can't be faked) 1:03:19 Why product quality and integrity matter in supplements Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter

CJC-1295 is one of the most purchased peptides in the research space. It is also one of the least understood.Most people pick it up because a friend told them to. Then they run into side effects nobody warned them about. Around 70% get injection site reactions. Plenty get flushing, hives, or headaches. That does not make it a bad peptide. It just means you should know what you are walking into.In this one I cover both versions, DAC and no DAC, and where I land on each. We get into how GHRH analogs signal the pituitary to release growth hormone. I explain the four amino acid swaps and why they matter. We also talk about the halted 2006 trial and the death that still follows this compound around.Then we get practical. Dosing tiers, why fasting is not optional here, cycle length, and the order I would introduce ipamorelin. I also cover who should skip CJC entirely and what to track while you run it.Human data on CJC is thin compared to tesamorelin. I say so where it matters.If you are running it already or thinking about it, this is the full picture.⚠️ For research and entertainment purposes only. ⚠️

Is Medication Right for Your OCD? A Psychiatrist Breaks Down SSRIs, Dosing, and What Actually WorksIf you've ever wondered whether medication could help your OCD or anxiety, or you've tried an SSRI and felt like "nothing worked," this episode is for you. Matt Codde, LCSW sits down with Dr. Melissa Quinn, a triple board certified psychiatrist who specializes in OCD treatment, for a full breakdown of how medication actually works, why so many people are underdosed, and how medication and therapy work together rather than against each other.Dr. Quinn walks through SSRIs, clomipramine, augmentation strategies, and common myths (including the cannabis conversation you don't want to miss), while Matt reframes ERP through the Restored Minds lens of emotional integration rather than symptom elimination.

In this episode of the Habit-Based Lifestyle Podcast, host Jesse Ewell welcomes Dr. Solomon Jon, a board-certified family medicine physician and expert in peptides. Dr. Jon shares his personal journey from traditional medicine to exploring the world of peptides and wellness. He discusses the challenges he faced in the medical community regarding the acceptance of peptides, the common mistakes people make when using them, and the importance of understanding dosing and sourcing. The conversation emphasizes the need for a balanced approach to health, integrating both traditional and innovative methods for optimal wellness. In this conversation, Jesse and Solomon dive into the complexities of weight loss, the importance of support systems, and the evolving landscape of peptide therapies.  They discuss the potential future of peptides in healthcare, the challenges posed by big pharma, and the need for more regulations. The conversation also touches on personal health habits and the impact of various peptides on health and wellness. Takeaways: • Dr. Solomon Jon transitioned from traditional medicine to wellness after personal health challenges. • Peptides can offer significant benefits for health and wellness, but they require proper understanding and application. • The medical community is often skeptical about peptides due to a lack of evidence and education. • Common mistakes in using peptides include not understanding dosing and sourcing. • It's essential to identify personal health goals before using peptides. • Dosing for peptides is not standardized, making it crucial to work with knowledgeable providers. • The future of peptides in medicine may involve more regulation and acceptance in the medical community. • Personal experience in health can enhance a provider's credibility and effectiveness. • Education and open-mindedness are vital in the evolving landscape of health and wellness. • The conversation around peptides is just beginning, and more professionals need to engage with this topic. Weight loss requires more than just a quick fix; habits matter. • Support systems are crucial for successful weight management. • Peptides can be life-changing when used correctly. • The FDA's role will shape the future of peptide therapies. • Big pharma faces challenges in patenting natural compounds. • The health industry resembles a 'Wild West' scenario. • Foundational health practices are essential for effective treatment. • GLPs show promise in metabolic health and weight loss. • Oral delivery of peptides could revolutionize their use. • Education and awareness about peptides are vital for practitioners. Reach out to Solomon Jon on Instagram Learn more about Jesse though the following links: HBL Lifestyle Secrets Group on Facebook Personal Website HBL Website Instagram Email

What if the GLP-1 conversation is bigger than weight loss? In this episode, I sit down with McCall McPherson, PA-C, thyroid expert and founder of Modern Thyroid Clinic. We have a candid, nuanced discussion about GLP-1 receptor agonists, the clinical questions that extend beyond the scale, and why safety, nutrition, medication sourcing, and individualized follow-up must stay at the center of the conversation. McCall shares the clinical observations that led her team to explore low-dose approaches with some thyroid patients, including questions around inflammation and autoimmune symptoms. We also discuss what is established, what remains under study, and why an episode conversation should never replace a personal discussion with a licensed clinician. Important clinical note: The episode includes discussion of microdosing and possible anti-inflammatory applications. These ideas may be outside FDA-approved uses and are not a plan for self-treatment. Do not start, stop, split, or change a prescription medicine without guidance from a qualified prescriber.

Most men would rather suffer in silence than admit they have a problem in the bedroom —Let's change that. On this episode of Taboo To Truth, I sat down with Jeff Abraham, CEO of Promescent, to talk about one of the most common yet least discussed issues in men's sexual health: premature ejaculation. We get into the real clinical definition of PE, why the "arousal gap" between men and women makes this a near-universal issue, and why anxiety — not selfishness — is usually driving the problem. Jeff breaks down the physiological and psychological causes of PE, why shame keeps so many men from seeking help, and why over 4,000 doctors recommend Promescent's Delay Spray. We also cover how the product actually works, how to use it correctly, dosing and titration, safety data from 3 million bottles sold, and how it compares to Viagra. Jeff gets personal too, sharing his own story of turning 69, how porn distorts expectations for young men, and the reality of the refractory period as we age. We close out talking about female pleasure, non-ejaculatory orgasms, and why using every tool available in the bedroom is nothing to be ashamed of. This is a candid, funny, and genuinely useful conversation for any man — or any partner of a man — who wants better sex and less anxiety about it.Use this link for 15% off Delay Spray: https://promescent.sjv.io/QY44bYIn This Episode:00:00 — The Silent Struggle Millions of Men Face 00:33 — Podcast Intro & Meet Your Host 01:05 — Welcome Jeff Abraham, CEO of Promescent 02:10 — What Really Counts as Premature Ejaculation 04:15 — The Arousal Gap & Why Anxiety Kills Intimacy 06:45 — Physical vs. Psychological Causes of PE 09:00 — Breaking the Stigma Around Men's Sexual Health 11:00 — Kegels, Combo Therapy & Why Urologists Trust Promescent 14:00 — The Old (Bad) Solutions: SSRIs and Numbing Creams 16:30 — Treating PE Step by Step & Weaning Off 19:30 — How Jeff Discovered Promescent (Origin Story) 22:30 — The Eutectic Formula That Changes Everything 25:00 — How to Use the Delay Spray: Application & Timing 27:30 — Dosing, Titration & Finding Your Sweet Spot 29:30 — Is It Safe? 3 Million Bottles, Zero Red Flags 31:00 — Promescent vs. Viagra & Doctors' Favorite Combo 33:30 — Does Age or Ethnicity Affect PE Rates? 35:15 — The PE-ED Connection & the Fragile Male Ego 37:00 — Jeff's Personal Story: Aging, Porn & Regret 38:30 — Where to Find Promescent, Discount CodeTo watch the video version of this episode, head over to YouTube!About the Guest:Jeff Abraham is the CEO of Promescent, a leading sexual wellness brand focused on making intimacy solutions more accessible and effective. After discovering a groundbreaking treatment for premature ejaculation developed by urologist Dr. Ronald Gilbert, Jeff invested in the product and became the majority owner, launching the company's flagship Delay Spray.Connect with Jeff Abraham:Website: https://www.promescent.comInstagram: https://www.facebook.com/Promescent/Delay Spray: https://promescent.sjv.io/QY44bYAbout the host: Karen Bigman, a Sexual Health Alliance Certified Sex Educator, Life, and Menopause Coach, tackles the often-taboo subject of sexuality with a straightforward and candid approach. We explore the intricacies of sex during perimenopause, post-menopause, and andropause, offering insights and support for all those experiencing these transformative phases.This podcast is not intended to give medical advice. Karen Bigman is not a medical professional. For any medical questions or issues, please visit your licensed medical provider.Looking for some fresh perspective on sex in midlife? You can find me here:Email: karen@taboototruth.comWebsite: https://www.taboototruth.com/Instagram: https://www.instagram.com/taboototruthYouTube: https://www.youtube.com/@taboototruthpodcastSubstack: https://karenbigman.substack.comWant more Taboo To Truth? Join the community HERELINKS, RESOURCES, EXCLUSIVE VIP DISCOUNTS & FREEBIES

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com  Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Oral Peptides for Appetite & Weight Loss, What Your Phase Angle Means for Your Cellular Health [0:00:00] Intro, Events Tease of the episode's themes: Segment 2: peptides and weight loss. Segment 3: phase angle and cellular health. Lung Coach event at Nutrition World – August 22 Mobile screening for early lung cancer detection. Emphasis that stage 1–2 lung cancer is often curable, stage 4 is not. Calcium score used to estimate plaque burden in arteries. Ed notes ~12 reasons for plaque formation, while most physicians focus on ~3. Mentions Dr. Kurt Dearing's book “Beyond Cholesterol”, covering broader causes of plaque. Financial health talk – August 22 (~11 AM) Michael E, financial planner, giving a free lecture on financial stability. Ed's point: two major life disruptors are declining health and declining finances, and they influence each other. Health Fair – October 24 Described as possibly the biggest health fair in the region. Features reps, free samples, circus‑like but “happy” atmosphere. [0:04:10] Restaurant Talk Light banter about Ed being a restaurant connoisseur and creature of habit. Restaurant recommendations via Ed's employee Fallon: Second Amendment / Second American (downtown). Hello Monty (special but reasonably priced menu). Ed's oxalate/joint pain story: Eating Purely Elizabeth cereal (high in oxalates: chia and other ingredients) triggered severe return of joint pain Discussion that some “healthy” foods can be nutritious but not healthy for everyone, especially for those sensitive to oxalates. Ed references his free oxalate ebook at theholisticnavigator.com and believes oxalates contributed to: His double hip replacement. Feeling old from age 50–65. Mentions OxyGuard supplement (recently restocked) and using 4 capsules/day to help clear excess oxalates (not as a license to keep eating high‑oxalate foods). Quick shout‑out to local farmers from Virginia End Farm selling at Nutrition World on Wednesdays (12–4), and that they've listened to every show. [0:8:55] Tease: Phase Angle & Seca Machine Ed previews Dr. Kurt Dearing's later segment on phase angle: A single number reflecting resilience and proximity to optimal health.. Mention of Be Well Labs / BeginwithLabs.com – Body Blueprint: Advanced lab panel: 50+ predictive health indicators. Pitch: more than a standard physical, actionable results. Price example: $275 vs typical $500, highlighting savings. [0:13:35] Segment Intro: Peptides & Weight Loss Framing: Peptides as one of the hottest trends in 47 years of Ed's experience. Shift from grey‑market injectables to safe, effective oral peptide powders. Ed has seen impressive feedback on an oral peptide powder for weight loss in early customers. [0:13:47] What Are Peptides? Protein basics: Proteins are long chains of amino acids essential for structure, function, and regulation. Peptide defined: A shorter chain of amino acids broken off from a larger protein. Lego analogy: Individual Legos = amino acids. Tall tower of Legos = full protein. Kid knocks tower over; a small intact stack (~8 Legos) that falls off = peptide. Each peptide has a “fingerprint” determined by: Length (how many amino acids/Legos). Sequence (order: e.g., red–red–blue–blue vs red–blue–red–blue). Processing (how it was broken off or created). Clarified: peptides are not primarily for fixing protein deficiency, but more for targeted signaling effects in the body. [0:20:52] Yeast‑Derived Oral Peptide for Metabolism & Drug Comparisons Endogenous peptides: made naturally inside the body. Exogenous peptides: introduced from outside (drug injections, supplements). Ozempic / GLP‑1 drugs: Yes, Ozempic is a peptide. These drugs are lab‑made peptides made to mimic natural body peptides. Peptides are not synthetic drugs in concept; they are peptide structures the body uses, though drugs are engineered. Focus on Ancient Nutrition “Active Peptide for Metabolism”: Contains a yeast peptide derived from Saccharomyces cerevisiae (brewer's yeast), broken from a larger yeast protein. Mechanism & effects: Influences hunger and satiety signaling: Increases leptin (satiety hormone). Decreases ghrelin (hunger hormone). Reported benefits: Reduced hunger and cravings (including boredom eating). Weight loss primarily from fat mass, not muscle mass. Comparison with GLP‑1 injections (semaglutide, etc.): Injections often cause muscle loss (e.g., “Ozempic face,” loss of facial muscle/fat). Yeast peptide research shows fat‑centric weight loss. Clinical results quoted: After 2 months, average daily caloric intake decreased by ~600 calories. Leads to meaningful weight loss, depending on baseline intake and muscle mass. [0:24:25] Dosing, Timing, Stacking & Safety Considerations How to take it: Once daily, typically in the morning to curb cravings throughout the day. Users report: easier recognition of fullness during meals. Stacking with cortisol peptide product: Ancient Nutrition also has a cortisol‑active peptide capsule for stress support. Same amount of yeast peptide per serving; research supports doubling the yeast peptide dose, so: You can use the metabolism powder + cortisol peptide together. Stress, cortisol, and weight: Chronic stress and high cortisol promote fat gain. Stacking stress support + appetite control may help body composition. Onset of effect: Reagan reports she personally noticed benefits around 2 weeks (quicker than many supplements that take 60–90 days). Cost & practicality: Approx cost around $50 for 30 days. Positioned as a cost‑effective alternative or complement to expensive injections. Side effects vs injectables: Reagan's hospital experience with GLP‑1 side effects (e.g., gastroparesis, impaired gastric motility, some requiring tube feeds or IV nutrition). Oral yeast peptide described as gentler, working with natural processes, not “forcing” the system. [0:30:09] Yeast Source, Candida Concerns & Usage Notes Yeast strain: Saccharomyces cerevisiae (not S. boulardii, and not pathogenic/candida). Clarifications: Will not cause yeast infections. Will not feed candida overgrowth. Taste & preparation: Chocolate flavor described as surprisingly good, even for those picky about chocolate. Temperature-sensitive: Must be mixed with cool liquid (NOT hot coffee/tea or hot beverages). Leaving it in high heat (e.g., hot car) can degrade activity. [0:36:03] Segment Intro: Phase Angle & Seca Scan with Dr. Kurt Dearing Discussion of: Seca medical‑grade bioelectrical impedance analysis (BIA) machine (~$12,000). It's commonly in hospitals/clinics, but rarely publicly accessible; Nutrition World and Be Well Labs both have one. Dr. Dearing's consult package: Includes consult + Seca scan + follow‑up visit + follow‑up Seca scan (~$195, promo if listeners mention the show). [0:37:35] What Is Phase Angle? (Deep Dive into Measurement & Meaning) What the Seca scan measures: Total body fat and visceral fat. Muscle mass (overall and by body segment). Phase angle (key focus). Phase angle basics: BIA sends low‑level alternating electrical currents through the body. The phase shift (time/angle difference) between current and voltage is measured. That phase shift = phase angle. Higher phase angle → healthier cell membranes, better cellular integrity, more muscle mass, better hydration. Lower phase angle → often malnutrition, chronic disease, frailty; can be used in dialysis, cancer patients, etc., to predict outcomes. Used as a longevity biomarker: Akin to an “EKG of your cells”. Can function as an early indicator for overall health trajectory, barring accidents Dr. Dearing's personal story: First scan categorized him as “bronze” on Seca's scale: Levels: None → Bronze → Silver → Gold → Platinum. Motivated him to increase strength training and eating healthy. Subsequent scan: improved from bronze → gold. Ed's anecdote: Friend and gym member Fred now tests as platinum, after sustained gym and nutrition efforts. Phase angle as a guide: If results are poor, that's a signal to upgrade the plan (diet, exercise, supplements). If phase angle improves (e.g., 4 → 5), it proves the plan is working, beyond just “feeling” better. [0:43:47] How to Improve Phase Angle (Practical Protocols) Key drivers and interventions: 1. Strength Training & Exercise Primary recommendation: resistance/strength training to build muscle mass. 2. Adequate Protein Ed's guideline: ~1 gram of protein per pound of body weight (men; women can often target ~¾ g per pound). Protein shakes often needed to hit targets. 3. Hydration & Electrolytes Proper cellular hydration improves phase angle. Maintain consistent fluid intake and electrolyte balance (sodium, potassium, magnesium). Avoid excessive diuretics/water pills. Dehydration causes phase angle to drop sharply. 4. Inflammation Control Systemic inflammation lowers phase angle and contributes to chronic disease. Tools: Anti‑inflammatory diet (Mediterranean‑style, high in omega‑3s). Omega‑3 fatty acids. Curcumin. Vitamin D optimization. Also includes sleep quality and stress management. 5. Foundational “Core Four” Supplements (Nutrition World concept) Covering: magnesium, zinc, vitamin D, B vitamins, etc., as baseline. 6. Targeted Add‑ons Creatine (supports muscle and cell energy). HMB (beta‑hydroxy beta‑methylbutyrate) – often paired with creatine. CoQ10 (mitochondrial and cellular energy). Phosphatidylcholine / BodyBio PC – to improve cell membrane integrity. [0:52:45] Closing Reflections Ed reads and comments on an article by Dr. Sircus about: Many doctors being “misaligned”: intellectually capable but no longer listening. Critique of: Over‑reliance on credentials. Under‑reliance on open‑mindedness and corrections. Emphasis that many clinicians are excellent listeners and deeply caring, but that institutional habits can discourage listening.  The post Radio Show / Podcast – July 26, 2026 first appeared on Vital Health Radio.

In this video, I explain what AMPK is and its central role in metabolism and aging. Discover how AMPK activation can lead to significant fat loss and improved metabolic function. We also explore the extensive AMPK benefits, including enhanced cellular respiration and reduced oxidative stress, offering valuable longevity tips.CHAPTERS00:00 Why ATX-304 Matters for Energy & Longevity00:48 What AMPK Is and Why It Controls Metabolism01:48 What ATX-304 Actually Does02:58 The Potential Health Benefits04:24 ATX-304 vs PQQ and CoQ1005:18 Safety, Dosing, and What We Don't Know06:13 Final Thoughts on ATX-304Connect with Dr. Greg JonesGet 10% off your first order at Dr. Jones Supplement Store when you join the email list. https://drjonessupplements.com/Instagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/

How do you build stronger, more powerful footballers when there is barely enough time to recover between matches?In this episode, Nick Grantham shares how his approach to strength and conditioning has evolved after years working in elite Olympic sport and the English Premier League. The conversation explores why strength remains a cornerstone of elite football performance, how to individualize training across a congested season, and why chasing the "perfect" gym session may no longer be the answer.Nick also explains the concept of nano dosing, using small but meaningful strength exposures throughout the week, while discussing minimum effective dose, player monitoring, injury mitigation, and balancing long term athletic development with match readiness.Interested in learning more about the latest developments in endurance performance and sports science? Subscribe to the HIIT Science email list for updates on new research, courses, and educational opportunities.Today's speakers:Dr Martin Buchheit https://martin-buchheit.net/    Nick Graham https://www.linkedin.com/in/nickgranthamconsultancyltd/Athletica Uhttps://youtube.com/playlist?list=PLu7L8NU083obOOZnkl9qd1lxr5zfVKTkL&si=YkGXTSQsJcYBUPiD

All Links Here: https://hunterwilliamshealth.com/linksIpamorelin might be the best peptide to start with if you have never touched growth hormone.In this masterclass I break down why. It pushes out your own growth hormone without dragging cortisol, prolactin, or hunger along with it. That clean profile is the whole reason it is still around.I go through what it actually does in the body. It starts at the ghrelin receptor and ends with IGF-1, which carries the real benefits. Better sleep, better recovery, better skin and hair over time.I cover who this is for. Anyone over 35, and especially women in their 40s and 50s who have never tried a growth hormone peptide.Then I get practical. Dosing tiers, the threshold where more stops helping, and how to cycle it. Plus how to stack it with CJC-1295 NoDAC the right way. I also explain why I have people run ipamorelin alone before adding anything.If you are on a GLP-1, this pairs really well and helps protect your muscle.We do not have a mountain of human trial data here. I am honest about that. But the safety record is mature and the anecdotal results are strong.If you are curious about growth hormone, start here.

How have 3 years of real-world experience with complement inhibition changed when and how retina specialists treat GA? In episode 2 of the GA in Practice miniseries on New Retina Radio, moderator Geeta Lalwani, MD, and panelists Murtaza Adam, MD, and Carl Danzig, MD, examine how referral patterns, safety data, and extension study findings have shifted their approach to early treatment. The group then works through a hypothetical case of an active 73-year-old patient with extrafoveal GA and intermediate AMD in the fellow eye, exploring how lesion characteristics, CNV risk counseling, and months-long travel schedules factor into the treatment decision.

S-Ketamine is now part of the TCCC pharmacopeia; you'd better understand how to use it. Dennis sits down with Pat — a veteran military anesthetist, former Danish Special Operations medical leader, and decades-long ketamine expert — for a deep dive into S-Ketamine. From its development and real-world use in austere environments (including Afghan war wounded and British Field Hospital MERT ops) to practical dosing, side effect management, and why it outperforms morphine in many trauma scenarios, this conversation delivers battle-tested wisdom for medics, PAs, nurses, and SOF operators.Pat shares hands-on lessons from hospital, military, and austere settings: achieving the "thousand-yard stare," managing emergence phenomena, combining with regional anesthesia, IM/IN/rectal routes, and why ketamine shines for hemodynamically unstable patients, refractory asthma, and more. They also discuss training pitfalls, the value of hands-on experience (including vet collaboration ideas), and cultural differences in patient responses.Key Takeaways:S-Ketamine is roughly twice as potent as racemic ketamine — use ~half the dose, but expect the same onset, duration, and side-effect profile (with potentially milder psych effects at mid-doses).Excellent for analgesia and procedural sedation in austere settings; superior hemodynamic stability compared to opioids in hypovolemic trauma patients.S-Ketamine is now included in the 2026 TCCC updates — critical knowledge for every combat medic and austere provider.Practical tips: titrate slowly IV, watch for nystagmus/thousand-yard stare, prepare for emergence with low-dose midazolam + patience, consider regional blocks to reduce opioid needs.Training emphasis: objective endpoints, patient monitoring, planning for side effects, and real-world experience over rote memorization.Whether you're running a prolonged field care scenario, managing a screaming femur fracture, or preparing for the next deployment, this episode arms you with actionable strategies.Subscribe, share with your team, and visit prolongedfieldcare.org for free resources, downloads, and more. PFC Coffee links in the description — fuel for the fight.#ProlongedFieldCare #Ketamine #AustereMedicine #TCCC #SOFMedicineChapters:00:00 Intro & Sponsors + Guest Welcome (Pat's Background)03:30 S-Ketamine vs Racemic Ketamine: Potency, Dosing, and Myths08:45 Early Experiences – Afghan War Wounded & Mass Casualty Ketamine Sedation14:20 Sedation Technique: Thousand-Yard Stare, Nystagmus, Airway Management, Atropine20:10 Emergence Phenomena, Cultural Differences, and Midazolam Management25:50 Battlefield Analgesia – Ketamine Superiority Over Morphine (Bastion Study)30:40 Dosing Strategies: IV Titration, IM/IN/Rectal Routes, Bioavailability37:15 Training Realities – Avoiding the “Middle Zone,” Objective Endpoints, Vet Collaboration43:30 Regional Anesthesia + Ketamine Synergy (Chester Buckenmaier Influence)47:20 Special Populations: Kids, Hemodynamically Unstable, Asthma, Head Trauma, Seizures53:10 Practical Tips for New Providers, Mission Planning, and Austere Pearls58:40 Closing Thoughts & ResourcesFor more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠⁠

Urolithin A (Mitopure) and Mitochondrial Renewal--Muscle, Immune, and Skin Benefits: Jen Scheinman, MS, RDN, CDN, Director of Science Communications at Timeline details urolithin A and Timeline's branded supplement Mitopure. She describes urolithin A's discovery through pomegranate research and worm studies showing a 45% lifespan increase. She discusses human research including improved walking distance and clinical outcomes in muscle endurance and strength. Urolithin A is presented as supporting mitochondrial health by promoting mitophagy—recycling damaged mitochondria—distinct from other mitochondrial supports like CoQ10 and NAD precursors. They explain most people cannot produce enough urolithin A from foods because only 30–40% convert precursors via the microbiome and it would require about six cups of pomegranate juice daily. Dosing discussed is 500–1,000 mg/day via gummies, capsules, or powder, with effects developing over months. She reviews emerging research on immune aging, preclinical work on brain and neurodegenerative conditions, and topical urolithin A for skin.

Sarah Kennedy of Calocurb explains why food noise spikes in perimenopause: falling estrogen raises cravings while the hindbrain overrides forebrain willpower under stress or poor sleep. She contrasts natural appetite hormones (GLP-1, GIP, CCK, PYY) with pharmaceutical GLP-1 agonists, which run at roughly 3,000% physiological levels versus the body's natural 300% rise - explaining rebound hunger after stopping injectables. Calocurb, a hops-derived bitter compound, stimulates a 600% natural hormone rise for an 18% average calorie reduction. WHAT YOU'LL LEARN Why food noise isn't a willpower problem, and what's actually happening in your hindbrain versus your forebrain when cravings take over How declining estrogen in perimenopause changes your calorie needs even as cravings increase What GLP-1, GIP, CCK, and PYY actually do in your body, and how they differ from each other How pharmaceutical GLP-1 agonists compare to your body's own natural hormone levels, and what that gap means for nutrient intake Why coming off a GLP-1 medication can trigger intense rebound hunger, and what's happening hormonally during that transition How bitter taste receptors throughout your gut influence appetite signaling, and why this evolutionary mechanism matters What role the luteal phase, travel, and sleep deprivation play in cravings, and how timing strategies can offset them TIMESTAMPS 00:00 - Intro  00:58 - Willpower vs. Biology: The Hindbrain-Forebrain Battle Driving Cravings  04:58 - GLP-1 Explained: How Natural Appetite Hormones Actually Work 10:21 – Supraphysiological Dosing on GLP-1 Drugs and Nutrient Sufficiency Risks  14:03 – Bitter Taste Receptors: The Gut-Brain Mechanism Behind Appetite Suppression  16:58 – Managing Mindless Snacking, Grazing, and the "Licks, Sips, and Dips" Problem  22:06 – Using Appetite Support Strategically During Weight Loss Plateaus  26:26 – Onboarding, Dosing, and Managing Digestive Side Effects  28:13 – Blood Sugar Regulation and New Clinical Research on Weight Loss Outcomes  30:51 – Why You Must Transition Off GLP-1s Strategically to Avoid Rebound Weight Gain  36:53 – Mood, Motivation, and the Liberating Effect of Quieting Food Noise  39:44 – Closing Thoughts VALUABLE RESOURCES• Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

In this episode of the TCOYD Podcast, Dr. Steve Edelman is joined by pediatric endocrinologist Dr. Anna Cymbaluk, along with Philip and his father Jim, to discuss the recent FDA approval of Afrezza inhaled insulin for children and adolescents living with type 1 diabetes. Dr. Cymbaluk served as an investigator on the INHALE-1 trial, while Philip participated in the study himself, providing a unique real-world perspective on what it is like to transition from injections to inhaled insulin, and Philip's dad, Jim provided the parent perspective as well as addressed parental concerns that might have arisen.The conversation focuses on the INHALE-1 study and the unmet challenges that continue to exist around mealtime insulin dosing in pediatric diabetes care. Dr. Cymbaluk reviews the trial design, glucose outcomes, safety data, patient satisfaction findings, and the practical realities of introducing inhaled insulin into everyday diabetes management. Philip and Jim share how Afrezza impacted school, sports, social situations, and the day-to-day burden of diabetes, particularly around pre-bolusing, corrections, and avoiding multiple injections throughout the day.Dr. Edelman and Dr. Cymbaluk also explore how Afrezza is dosed, how inhaled insulin differs from injected insulin, who may be a good candidate, and where it may fit alongside pumps and automated insulin delivery (AID) systems. For families looking for more flexibility, fewer mealtime barriers, and another option in the diabetes toolbox, this episode provides an honest look at the benefits, limitations, and real-world experience of inhaled insulin in children and teens.Key Topics• The FDA approval of Afrezza for children and adolescents living with type 1 diabetes• The design and results of the INHALE-1 pediatric clinical trial• Patient satisfaction and quality-of-life outcomes from the study• The challenges of pre-bolusing and mealtime insulin management in children and teens• How inhaled insulin compares to traditional mealtime injections• Dosing strategies, cartridge sizes, and insulin conversion considerations• Using Afrezza for corrections, meals, and post-meal dosing• The role of continuous glucose monitoring (CGM) when using inhaled insulin• Safety findings, lung-function monitoring, and cough management• Who may be a good candidate for Afrezza—and who may not be• Benefits for active children, athletes, and those participating in sports• Social situations, injection avoidance, and reducing the burden of diabetes management• Using Afrezza alongside insulin pumps and automated insulin delivery (AID) systems• The importance of having more treatment options to individualize diabetes careSupported by an unrestricted educational grant from MannKind CorporationSubscribe for practical diabetes management tips, technology updates, and treatment breakthroughs that help people with diabetes live healthier, more flexible lives.More diabetes resources:Website: tcoyd.orgBlog: tcoyd.org/blogPodcast: tcoydthepodcast.transistor.fmInstagram: / tcoydFacebook: / tcoydStay connected! Sign up for our monthly newsletter here!Support TCOYD's educational programs: tcoyd.org/donate ★ Support this podcast ★

Curious whether peptide therapy is the missing piece in your wellness routine, or just another overhyped trend? This episode breaks down what these powerful chemical messengers do in the body, from healing injuries to balancing brain chemistry, cellular energy and more, plus why sourcing and dosing make all the difference.Host Jenn Trepeck sits down with Dr. Aleksandra Gajer to explore BPC 157, brain-supporting peptides, and mitochondrial function, while tackling how to use peptides safely, who should avoid them, and why they work best as a tool rather than a magic fix-all.What You Will Learn in This Episode:✅ How peptide therapy acts as a chemical messenger system that supports the body's own healing pathways rather than overriding them✅ Why BPC 157 has become one of the most talked about peptides for tendon repair, gut healing, and recovery✅ How neuroinflammation, not just neurotransmitter imbalance, may be driving anxiety, depression, and brain fog✅ The role of mitochondrial function and insulin sensitivity in body composition, energy, and long-term metabolic healthThe Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Dr. Aleksandra Gajer's path from emergency medicine to proactive, personalized healthcare08:04 Defining peptides and their relationship to inflammation and healing10:04 Exploring BPC 157 for tendon injury, gut healing, and tissue recovery12:31 How peptides support autoimmune conditions by regulating immune balance15:35 Brain peptides Selank and Semax and the truth behind the neuroinflammation link to anxiety18:57 Understanding mitochondrial function, fatigue, and brain fog as cellular energy issues20:35 MOTS-c, insulin sensitivity, and the connection to body composition22:18 Why peptides work best as a tool, not a replacement for healthy habits26:03 Safe peptide sourcing, endotoxins, and who should avoid peptide therapy33:54 Hormone health, dosing strategy, and cycling peptides for sustainable resultsKEY TAKEAWAYS:

In this episode, we explore how the future of wellness is shifting away from endless optimization and toward a more personalized, less-is-more approach to health. We share our current favorite biohacks, discuss the benefits of an alcohol-free lifestyle, cycle syncing, peptides, and emerging technologies like the Ohm Lamp and stem cell therapies. We also unpack the growing backlash against "over-optimization" and why the next era of biohacking will prioritize precision, simplicity, and long-term resilience. Tune in for an inspiring conversation about aging well, supporting future generations, and why 2026 may be the most exciting time yet to take charge of your health.SHOW NOTES:0:40 Welcome to the podcast!2:15 Lauren's favorite biohack right now5:50 Foundational travel hacks6:40 Renee's rescue8:52 Renee's favorite biohack right now9:58 Benefits of no alcohol11:48 PhaseApp for cycle syncing15:31 The Ohm Lamp17:05 Revisiting peptides18:49 Comparison to microdosing23:29 RFK & new regulations24:43 Solving the problem of aging29:35 Excitement for the future of health32:15 Stem cells34:45 Supporting the senior population37:17 The era of ‘less' supplements44:35 Backlash trend of “over-optimization” 49:03 Major/minor signs on OURA50:33 Wellness centers53:26 Final advice & recap55:32 Thanks for tuning in!RESOURCES:Phase App - code: BIOHACKERBABESOhm Lamp - code: BIOHACKERBABESEllie MD PeptidesPeptide QuizEp 346: Addiction & Peptides with Samantha LanderEp 339: GLP-1 Dosing with Jay CampbellBiolongevity Labs - Discount code: BIOHACKERBABESEp 331: GP1 Biology & Calacurb with Sarah KennedyCalocurb - Discount code: RENEE10Dr. Vincent GiampapaBeam Minerals - Discount code: BIOHACKERBABES for 20% offKion Essential Amino Acids - Discount code: BIOBABES for 15% offEp 349: Airway Health & Snoring with Dr. Gene SambataroSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksBPC-157 is the peptide almost everyone starts with. In this masterclass I walk through why, and where the hype gets ahead of the evidence.We have about 30 years of animal studies on this one. We have fewer than 30 human subjects in published research. I keep that line clear the whole way through.I cover what BPC actually does. It helps the body repair tissue. It works on the gut, tendons, ligaments, and even the brain in animal models. It is not a steroid and it does not build muscle on its own. I explain how it works, who it helps, and who should skip it.Then we get practical. Dosing tiers, how to reconstitute the vial, how to inject near an injury, and how long before you feel anything.I tackle the cancer question head on. The fear is plausible on paper. The data does not really back it up. I tell you exactly where I land.We also cover cycling, the Wolverine stack with TB-500, oral versus injectable, and the FDA shift happening right now.Even if you already know this one, you will probably pick up something. If you are new to peptides, start here.

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode explores how to use GLP-1 medications like semaglutide/Ozempic and tirzepatide/Mounjaro safely and effectively. Dr. Mike Hart and Dr. Christle Guevarra Do discuss once-weekly dosing, individualized titration, optimal dose selection, food noise, appetite suppression, and the risks of dosing mistakes with vials or gray-market peptides. They also cover why resistance training, protein, fiber, and realistic nutrition habits are essential for preserving muscle and maintaining results. The conversation expands into GLP-1 benefits beyond weight loss, including cardiovascular protection, inflammation, autoimmune flares, addiction-related behaviors, alcohol cravings, libido, menstrual cycles, PCOS, sleep apnea, and what to expect when stopping the medication. Dr. Christle Guevarra Do is a physician focused on obesity medicine, GLP-1 education, weight management, and sustainable lifestyle change. Drawing from both her clinical experience and her own long-term use of GLP-1 medication, she helps patients understand how these medications fit into the bigger picture of long-term health. Her approach emphasizes individualized care, strength training, nutrition, behavior change, and realistic maintenance strategies rather than quick fixes. In this episode, she shares practical guidance for using GLP-1s responsibly while protecting muscle, managing hunger, and building habits that support lasting results. Dr. Christle Guevarra Website https://www.drchristle.com/ Dr. Christle's Free GLP-1 Guide https://www.drchristle.com/glp1-guide Dr. Christle Instagram https://www.instagram.com/dr.christle/ Ozempic — semaglutide https://www.ozempic.com/ Wegovy — semaglutide for weight management https://www.wegovy.com/ Mounjaro — tirzepatide https://mounjaro.lilly.com/ Zepbound — tirzepatide for weight management / sleep apnea https://zepbound.lilly.com/ FDA: Concerns With Unapproved GLP-1 Drugs https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss Retatrutide Clinical Trial Info https://clinicaltrials.gov/study/NCT05882045 Vyvanse — lisdexamfetamine https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Creatine — NIH Supplement Info https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Psyllium Husk / Fiber — MedlinePlus https://medlineplus.gov/druginfo/meds/a601104.html Berberine — NCCIH https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know Tesamorelin — MedlinePlus https://medlineplus.gov/druginfo/meds/a611035.html CJC-1295 — PubMed Research https://pubmed.ncbi.nlm.nih.gov/16352683/ Ipamorelin — PubMed Research https://pubmed.ncbi.nlm.nih.gov/9849822/ FDA: Peptides / Compounding Safety Concerns https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Oura Ring https://ouraring.com/ White Claw https://www.whiteclaw.com/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:45 Weekly Dosing Debate 03:41 Starting Dose Basics 06:28 Pens vs Vials Safety 08:37 Finding Your Sweet Spot 11:01 Nighttime Binge Window 13:32 Lifestyle Work Still Matters 14:30 Benefits Beyond Weight 17:27 Libido and Low Calories 22:26 Alcohol Hits Different 24:59 Cancer Claims Reality Check 26:59 Strength Training Priority 29:06 Supplements and Creatine 29:38 Creatine Protein Fiber Basics 31:50 Berberine Pros and Cons 32:37 Peptides Sleep and Muscle 35:28 Too Lean for GLP-1 38:52 Cycles PCOS and Fertility 40:45 Food Noise vs Appetite 44:42 Staying On or Stopping 49:19 Heart Rate and HRV Concerns 51:38 Ozempic vs Mounjaro Choices 54:45 Sleep Apnea and Wrap Up The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

What Really Happens Inside an Obesity Clinic GLP-1 medications are everywhere right now. Patients are asking about Ozempic, Wegovy, Zepbound, compounded medications, muscle loss, “Ozempic face,” insurance denials, and what happens when the weight loss slows down.But what does obesity medicine actually look like inside the clinic? In this episode, I'm joined by Joseph Zucchi, PA-C, clinical supervisor and physician associate at Transition Medical Weight Loss in Salem, New Hampshire. This is not your typical GLP-1 conversation. We're going beyond protein goals, nausea tips, and constipation management to talk about what clinicians are really facing in practice: how to dose these medications, when to switch, and how to support patients when insurance coverage disappears.In this episode, you'll learn:What to assess when a patient hits a weight loss plateau beyond simply increasing the dose  How to talk with patients about GLP-1 concerns like muscle loss, thyroid cancer warnings, GI side effects, and “Ozempic face”  Why obesity medications are tools, not “cheating,” and how to address weight stigma in the exam room  What clinicians should know about compounded GLP-1 medications and why FDA-approval matters  How to document for prior authorizations and what insurance companies are often looking for  What happens when patients lose GLP-1 coverage and how to discuss alternative medication options  What Joe is most excited about in the future of obesity medicine, including new medications and expanding coverage If you prescribe GLP-1 medications, counsel patients on weight management, or feel overwhelmed by the insurance and documentation side of obesity medicine, this episode will give you a practical, behind-the-scenes look at what comprehensive obesity care can look like.Connect with JoeResources mentioned:Obesity Medicine Nutrition Course (with a 2026 medication update) Use code POD15 for 15% off!155 | Unstuck: Strategies for Sustainable Weight Loss151 | Are GLP-1s Masking Undiagnosed Eating Disorders?Obesity Medication InfographicAny Questions? Send Me a MessageSupport the showConnect with Colleen:InstagramLinkedInSign up for my FREE Newsletter - Nutrition hot-topics delivered to your inbox each week.Disclaimer: This podcast is a collection of ideas, strategies, and opinions of the author(s). Its goal is to provide useful information on each of the topics shared within. It is not intended to provide medical, health, or professional consultation or to diagnosis-specific weight or feeding challenges. The author(s) advises the reader to always consult with appropriate health, medical, and professional consultants for support for individual children and family situations. The author(s) do not take responsibility for the personal or other risks, loss, or liability incurred as a direct or indirect consequence of the application or use of information provided. All opinions stated in this podcast are my own and do not reflect the opinions of my employer. 

Most men think erectile dysfunction is a bedroom problem and low testosterone is just a fact of getting older. This roundtable makes the case that both are early warning lights for your heart, your metabolism, and your long-term health and that ignoring them can cost you a decade.In this episode, Dr. Gabrielle Lyon sits down with urologists and men's health specialists Dr. Mohit Khera, Dr. Larry Lipshultz, and Dr. Tobias Köhler to discuss:Why a 35-year-old with ED carries a ~15% risk of heart attack or stroke within 7 years, ~3.5x the risk of depression, and ~30% odds of diabetes or prediabetes and why a prescription alone misses all of itWhy "age-related" testosterone decline is largely a misnomer: a healthy man shouldn't drop significantly with age, so falling T usually signals something reversible underneathHow testosterone became the single best blood marker of a man's overall health, and the case for annual screening that almost no man getsWhat the TRAVERSE trial changed when the FDA removed testosterone's cardiovascular warning in 2025, debunking the prostate-cancer and heart-attack fearsThe 2-minute monthly self-exam every man should do to catch testicular cancer early, when it's ~99% curableIf you've been told your symptoms are "just aging" or you love a man who refuses to see a doctor. This conversation shows you how to read the signals your body gives long before a crisis hits.Thank you to our sponsors:Body Health - Use the code LYON20 to get 20% off your first order https://bit.ly/4efgBuMTimeline - Get 20% off your Mitopure order at https://bit.ly/49LSbYzBranch Basics - Save 15% at https://bit.ly/4uuw4x3 with code DRLYONExplore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Larry Lipshultz at:Instagram: https://www.instagram.com/lipshultzmd?igsh=NTc4MTIwNjQ2YQ==Website: https://www.larrylipshultz.com/YouTube: https://www.youtube.com/@DrsAmyandLarryFind Dr. Tobias KohlerInstagram: https://www.instagram.com/tobiaskohlermd?igsh=NTc4MTIwNjQ2YQ==X: https://x.com/sexhealthmd?s=11Find Dr. Mohit KheraInstagram: https://www.instagram.com/drmohitkhera?igsh=NTc4MTIwNjQ2YQ%3D%3DX: https://x.com/DrMohitKheraWebsite: https://drmohitkhera.com/Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyonX (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyonChapters00:00 - Introduction01:30 - What doctors got wrong about testosterone05:05 - The prostate cancer myth, debunked07:12 - The best marker of a man's health11:51 - Is age-related decline actually real?14:15 - How obesity crushes testosterone18:11 - Testosterone and reversing diabetes20:06 - GLP-1 versus testosterone25:20 - What "low testosterone" really means29:05 - Dosing, CAG repeats, and microdosing42:34 - The TRAVERSE trial and FDA reversal47:10 - The prostate saturation point56:49 - Peptides, explained01:03:00 - Why ED is a check engine light01:08:26 - The desert of men's health care01:11:06 - The case for annual screening01:16:45 - Varicoceles and male fertility01:20:03 - How to check for testicular cancer01:26:44 - Final advice for menIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

In this episode: Mark creates DOSsier, a system for retro PC gaming. Martin replaces his editor (again), this time with Fresh Alan creates a new app for event attendance. You can send your feedback via show@linuxmatters.sh or the Contact Form. If you’d like to hang out with other listeners and share your feedback with the community, you can join us on: The Linux Matters Chatters on Telegram. The Linux Matters Subreddit. If you enjoy the show, please consider supporting us.

In this episode: Mark creates DOSsier, a system for retro PC gaming. Martin replaces his editor (again), this time with Fresh Alan creates a new app for event attendance. You can send your feedback via show@linuxmatters.sh or the Contact Form. If you’d like to hang out with other listeners and share your feedback with the community, you can join us on: The Linux Matters Chatters on Telegram. The Linux Matters Subreddit. If you enjoy the show, please consider supporting us.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksKPV is the most underrated peptide out there. Almost nobody talks about it. In my opinion it should be one of the most demanded peptides we have. If I had to choose, I'd take it over BPC and TB-500 every single time.Here's why. KPV is a tiny three amino acid fragment of alpha-MSH. It directly blocks NF-kappa B, the master switch your body uses to turn inflammation on. Most peptides work around the edges. KPV shuts the alarm off at the door.In this one I cover all of it. What KPV is and how it works. Who actually benefits. Dosing by tier and by purpose. How to stack it with BPC, TB-500, LL-37, and your GLP-1. What to track on bloodwork. Cycling, sequencing, troubleshooting, and a full FAQ.If you've ever run a protocol that worked and then stalled out, this one is for you. Inflammation is almost always the rate-limiting step in healing.Make sure you're on the email list. And come join us in the Axion Collective for live coaching every Thursday.⚠️ For research and entertainment purposes only. ⚠️

Red light therapy is now at Target. It's on Amazon by the thousands. And with that explosion comes a mountain of marketing claims, spec sheet arguments, and consumer confusion that has Freddie and Scott Kennedy — founder of Light Path LED and one of the most science-grounded voices in photobiomodulation — more motivated than ever to cut through the noise. In this fifth conversation across seven years together, they break down exactly what happens at the cellular level when red and near-infrared light hits your body: how cytochrome C oxidase absorbs photons, why that turbine in your mitochondria spins faster, how nitric oxide release drives vasodilation and blood flow, and why the gap between 700 and 800 nanometers is essentially a dead zone. They also get real about power, irradiance, pulsing frequencies, and why the best panel in the world won't save a business model built on charging $100 a session for red light alone. The second half of this episode is a full product walkthrough of what Scott has been building — including the new Titan, a six-foot full-body panel with an electric adjustable stand designed to deliver what $60,000 red light beds do at a fraction of the cost, and the TLC dork cap — three years in development, covering the full head, jaw, cervical lymph nodes, and occipital region with red, near-infrared, and blue light at 10 and 40Hz pulsing. Freddie and Scott also explore the torch, intranasal red light delivery, dental and gum applications, stacking red light with peptides for injection site activation, and the honest conversation about what a sustainable red light business model actually looks like in 2026. Use code BEAUTIFULLYBROKEN at lightpathled.com for a discount.   Episode Highlights   [00:00] – Red light therapy goes mainstream and why consumer confusion is exploding [02:10] – Scott's dental laser background and how he discovered photobiomodulation [04:32] – Why red light supports the body instead of directly “treating” conditions [06:22] – How light increases ATP, blood flow, oxygenation, and downstream cellular benefits [10:00] – The difference between red light and near infrared light [12:11] – What happens at the cellular level with mitochondria, cytochrome C oxidase, and nitric oxide [18:45] – Why irradiance and power claims can be misleading for consumers [24:32] – Therapeutic dose, joules, timing, and why more is not always better [30:53] – The problem with too many wavelengths and marketing-based panel design [36:05] – Lightpath LED's wavelength choices, pulsing features, and near infrared focus [44:11] – The Titan panel and why Scott designed a simpler full-body red light option [45:51] – The Dork Cap, blue blockers, torch attachments, and practical red light tools for daily use   Upgrade Your Health   LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken   MaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKEN Code: beautifullybroken   The Biological Blueprint Course: https://www.beautifullybroken.world/biological-blueprint Earn 200 in BitCoin + Change your health   BEAM Minerals: http://beamminerals.com/beautifullybroken Code: BEAUTIFULLYBROKEN   Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN   StemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52 Code: beautifullybroken CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Claim your complimentary gift of my exclusive mini weight care guide today!Link: Weight Care Guide — Dr. Francavilla Show (thedrfrancavillashow.com)What if the reason so many people struggle on GLP-1 medications isn't the medication itself — but the way it's being dosed?Today we're diving into something that could genuinely change the way you think about GLP-1 therapy: custom dosing. And there is honestly no one better to talk about this with than Dr. Ian Justl Ellis.Dr. Ian is a board-certified physician, certified personal fitness instructor, and the creator of the MyLevel GLP-1 Precision Dosing Engine. He's also the founder and CEO of VOA Fit, where he provides highly personalized concierge care through advanced GLP-1 therapy, hormone optimization, and peptide protocols — all paired with real-world fitness and nutrition strategies. Before transitioning into obesity medicine, he spent a decade in emergency medicine.What makes his perspective especially valuable is how he bridges clinical expertise with lived experience in weight management. His work doesn't just focus on prescribing GLP-1s, but on optimizing how they're actually used in real-world patients. And that's exactly what this conversation is about — how dosing strategy can completely change outcomes.Topics discussed:Why GLP-1 results may depend more on dosing than the medication itselfDr. Ian's early belief in discipline — and why it eventually broke downWhen personal struggle turned into a medical reframe of obesityThe first experience with GLP-1s and the reality behind the resultsWhy “dose” isn't the full story — understanding GLP-1 drug levelsMoving from standard protocols to individualized GLP-1 levelingHow personalized GLP-1 dosing works in real patientsThe future of GLP-1 therapy: a more responsive, guided model of careRethinking weight loss: from fixed doses to adaptive biologyThere's a lot more nuance to GLP-1 therapy than standard protocols tend to show, and this episode really breaks down what happens when dosing becomes personalized rather than fixed.So if you want to understand how this approach actually works in practice — and why it might completely shift how we think about weight management — tune in to the full episode.Connect with Dr. Ian:Website: voafit.com,Instagram: voafitmdLearn about MyLevel:  voafit.com/mylevelBook a Consult: go.voafit.comMeet Our Clinic: voafit.comConnect with me:Instagram: doctorfrancavillaFacebook: Help Your Patients Lose Weight with Dr. FrancavillaWebsite: Dr. Francavilla ShowYoutube: The Doctor Francavilla ShowGLP Strong: glpstrong.com

Deb 00:00:01Imagine your body has a repair manual, instructions written in your cells that tell tissues how to heal, blood vessels, how to grow, and inflammation when to stop. But what if those instructions got lost somewhere along the way? Well, today I’m talking about peptides, tiny protein fragments that act like biological text messages. Two of them, BPC 157 and TB 500.They’re showing remarkable promise for gut repair, joint recovery, and tissue regeneration. But here’s what nobody’s telling you. Women respond differently to these healing signals, especially during hormonal transitions. And today, we’re uncovering the science behind these regenerative peptides, who actually needs them, and why your doctor might not know about them. Can you guys put our ad right in here and then I’ll go to the standard intro?Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb, your medical detective. And today we’re diving into regenerative peptides BPC157 and TB 500. If you or someone you love is struggling with slow recovery from injury, chronic joint pain, gut inflammation that just won’t quit, or you just feel like your body doesn’t bounce back the way it used to, this episode is for you. Grab a cup of coffee or tea or whatever helps you unwind, settle in, and let’s start you on your journey to deeper healing. We’ll do another sponsor break here. Deb 00:01:52So let’s start with the question I hear constantly in my practice. Dr. Deb, I’m doing everything right. I’m eating clean, I’m exercising, I’m taking my supplements, but I’m still not healing. What am I missing? Well, that answer might surprise you. Sometimes it’s not about what you’re putting in your body. It’s about whether your cells are actually receiving the repair signals they need. That’s where peptides come in. Think of peptides as The body’s original communication system. These short chains of amino acids are like biological post-it notes carrying instructions from one cell to another. They tell your human system when to calm down, your blood vessels when to grow and your tissues when to repair. Now here’s where it gets interesting for women specifically. We know that estrogen plays a massive role in collagen production, vascular health, inflammatory response. When estrogen starts declining, whether that’s perimenopause, postpartum, or even from chronic stress, our natural repair mechanisms slow down dramatically. You might notice it as my joints are aching more, I’m a little more fluid filled, you know, they hurt when I bend them, my injuries take twice as long to heal.Gut issues that suddenly appear out of nowhere and no matter what you do, they don’t seem to repair. Skin has lost its elasticity or just this general sense that your body isn’t keeping up anymore. This is where BPC 157 and TB 500 entered the picture. So BPC 157, short for body protection compound 157, is a naturally occurring peptide sequence found in your gastric juices. And according to a 2024 systemic review published in emerging use of BPC 157 in orthopedic sports medicine, this peptide promotes something called angiogenesis. That’s the formation of new blood vessels and they deliver oxygen and nutrients to damaged tissues. Now TB 500 is a synthetic fragment of thymus and beta-4. Deb 00:04:17A protein your body makes naturally during wound healing and research published in therapeutic peptides in orthopedics in 2025 shows that it works like a cellular first responder rushing to injury sites and coordinating tissue repair through a process called actin regulation. But here’s what makes these peptides different from just taking another supplement. They don’t force your body to do anything.They simply remind yourselves how to heal the way they used to. And for women navigating hormonal changes, autoimmune flares, chronic inflammatory conditions, that distinction matters enormously. all right, let’s get into some of these mechanisms because understanding how something works helps you make informed decisions about whether or not it’s right for you. So,Let’s look at the science. Do these peptides actually work? And if so, how do they work? Let’s start with BPC 157. This works through multiple pathways simultaneously. First, it activates growth factor receptors that stimulate fibroblasts. Those are the cells responsible for making collagen and rebuilding connective tissue. And according to research published in Frontiers and Pharmacology in 2023, titled Regeneration or Risk, BPC 157 also modulates nitric oxide signaling, which enhances vascular repair and reduces oxidative stress at the cellular level. So this is really important because many of us are nitric oxide deficient, especially as we get older, especially since the pandemic, we’re seeing a lot of people being more deficient in nitric oxide and you’re taking nitric oxide, many of you, to help with this process. But if we’re having other issues that don’t allow that nitric oxide to get where it needs to go, that could render it completely useless. So in plain English, when we’re talking about how BPC 157 helps the blood vessels work better and protects your mitochondria, big word for your energy factories and your cells from that inflammatory damage. Deb 00:06:38Now there’s studies in musculoskeletal and gastroenterology models that show BPC157 decreases inflammatory cytokines like TNF-alpha and IL-6. And these are chemical messengers that keep inflammation turned on. So by dialing them down, BPC157 creates an environment where healing can actually happen. Now, where do we know about this?TNFL and IL-6, well, we know it from viruses, we know it from Lyme disease, we know it from mold toxicity. These cytokines are turned up, they’re creating a massive inflammatory response in the body, and you’re struggling to get these things down because of that or potentially other reasons. So here’s where it gets really interesting with women in perimenopause or menopause. When estrogen declines, collagen synthesis slows down. And that’s why we see increased joint pain, slower wound healing, and our changes in the skin’s elasticity during this transition. We see the little wrinkles, the fine lines, we see the subcutaneous fat going away a little bit more. This is partially why this is occurring. And so from research shown in the Journal of Orthopedic Research in 2023 by Leibowitz and colleagues, that they suggest that BPC157 affects on the endothelial layers. So the cells lining the blood vessels and these may mimic some of the estrogen’s protective vascular effects without actually affecting your hormone levels. This is really huge because we know that as women lose estrogen, they have a higher risk for vascular events, heart attack, stroke, things like that. And if people have already had a heart attack or a stroke, We typically recommend that they don’t use estrogen because that could potentiate the risk for another heart attack or a stroke. But that means that you don’t gain the benefits of estrogen either. So if we think about this, we could potentially use BPC 157 to give us some of the benefits that we lost from having estrogen and potentially not being able to use estrogen. And that would be huge for us. Deb 00:08:57And not to mention the reduction of inflammation and the joint pain and the wound healing and the energy and the gut feelings. I mean, there’s just so many benefits to BPC 157 that we could talk about them all day long. But we’ve got to move on. So let’s talk about TB 500. Now this peptide works very differently. Its primary job is promoting cell migration, essentially telling repair cells to go to this spot and what to do when they get there. So it sends a signal, puts a little post-it stamp there and says, Hey, when you get there, fix A, B, C, and D. And there was a study in 2024 in cell biology international that demonstrated that TB 500 increases epithelial closure and improves tendon elasticity in models of repetitive strain injury. So let’s think about that a little bit. What does that really mean?That means faster recovery from exercise induced muscle damage, better healing of overuse injuries like tennis elbow or plantar fasciitis, improved scar tissue remodeling after surgery or a C-section, enhanced recovery from chronic inflammatory conditions affecting soft tissues. And I’ve talked about this several times. I have used these compounds post-surgical personally.And I remember going back to see my surgeon at the two to three week mark for follow-up. And she was amazed at how well everything was healing. And when I asked her if she wanted to know what I was doing, her response was no, but keep doing whatever you’re doing because it’s working. And after three weeks of a major pelvic repair surgery that I had, four hours in surgery, lots of sutures, not comfortable. I was actually walking a mile and didn’t have pain and I was recovering really well and felt amazing. And that is just not typically heard of in surgical procedures like mine. It’s usually a minimum of a six to eight week recovery before you’re starting to do that again. And I give all of the credit to these two peptides. Deb 00:11:17In my clinical practice, I see this play out constantly. Women who train hard, whether that’s CrossFit, running, yoga, or just trying to keep up with active kids, often hit a wall where their recovery can’t keep up pace with their activity level. And TB 500 helps to bridge that gap by optimizing the body’s natural repair timeline. But here’s what I want to emphasize with you. These peptides aren’t magic bullets.They work best when we combine them with proper nutrition and anti-inflammatory diet, adequate sleep, stress management, and we address the underlying root cause like the gut dysfunction or those hormonal imbalances. And they work much better when the hormones are balanced versus when they’re not. They’re amplifiers of your body’s existing healing capacity, not replacements for foundational health practices.So let’s have some real talk here. Let’s talk about evidence and what you need to know about that. Let’s take a drink, sorry. Now let’s address the elephant in the room. Regulatory status and safety. Neither BPC 157 or TB 500 are FDA approved for human medical use. They fall into a category called research compounds. And that means they’re legal to possess and use but they’re not approved as pharmaceutical drugs. And hopefully they will be back on our list of things to use relatively soon with the changes that Bobby Kennedy has made to peptides recently. So why does this matter? Because quality becomes a concern. Quality control is absolutely critical. You need to know where these compounds are manufactured, their source, their testing. their clarity, everything about them. There was a 2025 review in therapeutic peptides in orthopedics that concluded both peptides demonstrate strong regenerative signaling with minimal systemic side effects in preclinical studies. But, and this is really important, most of the robust data we have comes from animal models and cell culture models, not large scale human clinical trials. Deb 00:13:41Now that doesn’t mean that they don’t work. It just means that we are still in the early stages of understanding optimal dosing, treatment duration, and long-term effects in humans. So why do we have all of this great peptide information and we don’t quite have the ability to use them yet, or it’s extremely restricted?That comes under the guise of the FDA. came through the past administration with Biden where he removed a bunch of these peptides from the market. Both BPC and TB 500 were on the list of safe peptides to use before Biden made his changes. And it looks like they may be coming back relatively quickly for us here. So what we do have is growing clinical feedback from practitioners like myself. Who use these peptides in practice under careful supervision and under pilot studies on musculoskeletal recovery published in our organizations that we work with. So all of our information is documented and it is done under an observational study. There are other studies published in orthopedic and biomedical research from 2025.that actually found VPC-157 reduced pain scores by 35 % and improved functional mobility within eight weeks. This is really phenomenal because many people over the age of 40 are reaching for the Tylenol bottle, the Advil bottle, the Aleve bottle, which does a number on your kidneys and your gut and your liver. And it is really problematic to be using these things on a regular basis.And if we can use a compound that’s safe, that preserves the kidneys, the liver and the gut, why don’t we do that is the question that I have. Now, we see a lot of the same information in our clinic that we see in these studies. And it is the following things that we see. Significant reduction in joint pain and stiffness. I have a person that was looking at doing a knee replacement and we did 10 weeks of these two compounds. Deb 00:16:00And her knee pain reduced so much that she decided she didn’t feel like she needed that knee replacement right away, which is good because she is only 60 years old. And the length of that knee replacement wouldn’t be as long as it would if she could wait five or 10 years. The doctor didn’t say she needed to do it right away. She wasn’t that critical, but it was the pain that was driving her to the replacement. And so if we could preserve that and give her a reduction in pain, all the better to do that. We get faster recovery from surgical procedures, improved gut symptoms, especially in cases of leaky gut or inflammatory bowel conditions, better skin quality and wound healing, enhanced overall sense of resilience and recovery capacity. But here’s what you absolutely must know before considering peptide therapy. First, source matters. Because these aren’t FDA regulated pharmaceuticals, quality varies widely and you need to work with a physician who sources from compounding pharmacies 503A or 503B that provide certificates of analysis, third party testing and proper sterility verification. Secondly, context matters. Peptides work best as part of a comprehensive functional medicine approach. So if you’re still eating inflammatory foods, drinking alcohol, not managing your stress or your sleep, you have unaddressed gut dysfunction, and these peptides alone won’t fix those problems. Thirdly, realistic expectations matter. These aren’t overnight miracle cures. Most patients see gradual improvements over four to 12 weeks. Some respond dramatically, others see modest benefits. Individual variation is real. And fourth, medical supervision matters. Dosing, injection technique,monitoring for side effects and knowing when peptides are or are not appropriate. All of this requires clinical expertise. Now let me bust a few myths here because I hear this constantly. Myth number one, peptides are just for bodybuilders and athletes. That is false. While athletes use them for performance recovery, the therapeutic applications for chronic pain, gut healing and age related tissue decline are profound. Deb 00:18:26For everyday people. Myth number two, peptides will mess with my hormones. False. BPC-157 and TB-500 don’t interact with your endocrine system the way hormones do. They work through growth factors and cell signaling pathways. They are very different. Myth number three, if they’re not FDA approved, they must be dangerous. Not accurate.Many effective therapies exist in regulatory gray zones. What matters is quality sourcing, proper medical oversight, and informed consent. So the bottom line here is that these peptides show real promise backed by mechanistic science and growing clinical expertise, but they require responsible use, quality products, and realistic expectations. Now let’s talk about practical integration.Who should consider peptides? Well, so who actually benefits from the peptides? Let’s start there. Let me walk you through the three main categories I see. Number one is gut restoration. If you’re dealing with chronic gut inflammation, whether that’s IBS, inflammatory bowel disease, leaky gut, persistent digestive issues that haven’t responded to dietary changes alone, BPC 157 can be transformative.I had a patient recently, I’ll call her Sarah. She’s been struggling with severe gut pain and food sensitivities for three years. She tried elimination diets, probiotics, gut healing supplements, everything. And within six weeks of adding BPC 157 to her protocol, alongside the targeted nutritional therapy, her pain dropped by 70 % and she could tolerate foods that she hadn’t tolerated in years. Why does this happen? because BPC 157 directly supports mucosal integrity, the protective lining of your intestinal tract, and it reduces inflammatory cytokines and promotes healing of damaged tissue. Number two, muscle and joint recovery. This is where I see TB 500 shine. Women who are active, whether you’re a runner, a yogi, a cross-bitter, or someone who just wants to keep moving without pain. Deb 00:20:48They often hit a point where recovery becomes a very limiting factor. And maybe you’re dealing with chronic tendonitis, a nagging shoulder injury, a bad back that just will not quit, or just general achiness. It all makes you feel older and keeps you from being active the way you want to. TB 500 combined with therapies like red light therapy, PEMF, or targeted physical therapy, can dramatically accelerate soft tissue healing. I’ve seen recovery timelines cut in half for patients dealing with overuse injuries. Number three, menopausal transition support. This is where the intersection of peptides in women’s health gets really exciting. During perimenopause and menopause, declining estrogen affects collagen production, vascular health, and joint integrity, along with inflammatory processes and responses.Many women notice they just don’t heal as quickly and their joints hurt much more. Besides noticing their skin changes and their injuries linger longer. Low dose peptide protocols, often combining BPC157 for vascular and gut support with TB500 for soft tissue repair, can complement bioidentical hormone therapy or stand alone for women who can’t or don’t want to use hormones.Now I’m not saying that peptides replace your hormone optimization, but they can be powerful adjuncts that support tissue resilience during a time when your body’s natural repair mechanisms are shifting. Now, who should not use peptides? If you have any active cancer or a history of certain cancers, peptides that promote cell growth and angiogenesis might not be appropriate. If you’re pregnant or breastfeeding, we don’t have safety data.If you have severe kidney or liver disease, clearance and metabolism could be affected. You want to work with a practitioner who really understands this and be under medical supervision for these kinds of conditions. This really matters. A qualified functional medicine practitioner can assess your individual situation, run appropriate labs and determine whether peptides fit into your overall healing strategy. Remember, peptides are tools. They’re not magic. Deb 00:23:11They work best when you’re also addressing nutrition, sleep, stress, movement, and underlying root causes. They amplify your body’s healing capacity. They don’t replace the fundamentals. This is really important to understand. So thank you for joining me today on Let’s Talk Wellness Now. If this episode resonated with you, share it with another woman who’s ready to reclaim her body’s natural healing capacity. Remember, Wellness isn’t just about feeling good. It’s about thriving in every area of your life. Your body was designed to heal. You’re not a small version of a male. You are a woman with different biochemistry. And sometimes it just needs the right signals and the right support to remember how. If you’re ready to explore personalized regenerative medicine or peptide therapy as part of a comprehensive functional medicine approach,You can visit us at serenityhealthcarecenter.com. You can also follow us on Instagram, and you can look at my book, Seen at Last, and join the Seen at Last free community on Facebook, where we will provide all of this information and more for you. Until next time, I’m Dr. Deb, reminding you to take care of your body, mind, and spirit. Be well, and I’ll see you in the next episode.The post Episode 269 – Peptide Therapy for Women: How BPC-157 & TB-500 Heal Gut, Joints & Inflammation first appeared on Let's Talk Wellness Now.

With so many supplements marketed to runners, it's easy to wonder what's actually worth taking. In this episode, we cut through the noise and focus on a few supplements that have strong research behind them—while emphasizing that no supplement can replace consistent training, good nutrition, quality sleep, and proper recovery.We break down the Three Cs: Carbohydrates, Creatine, and Caffeine.First, we discuss why many runners are underfueling and how carbohydrates play a critical role in performance, recovery, and endurance. Next, we explore creatine monohydrate, one of the most researched supplements available, and its benefits for strength, recovery, and overall health. Finally, we cover caffeine, including how it can improve performance, common dosing guidelines, and why personal tolerance matters.We also briefly touch on vitamin D, magnesium, omega-3s, and collagen, and discuss when they may be worth considering.In This Episode:Why supplements should never replace the fundamentalsHow carbohydrates support performance and recoveryThe benefits of creatine for runnersHow caffeine can enhance enduranceWhen other supplements may be helpfulAvoiding the optimization trap and keeping things simple03:53 The Three Cs 09:59 Fueling During Runs14:29 Carb Targets And Gut Training20:16 Women Over 40 And Carbs25:03 Adjusting Fuel To Effort28:31 Creatine Explained41:14 Monohydrate and Daily Dose43:25 Caffeine Performance Basics46:23 Dosing and GI Timing47:33 Metabolism and Jitters50:29 Sleep and Tolerance Tradeoffs54:12 Race Day Caffeine Rules56:54 Vitamin D Testing59:34 Magnesium for Cramps01:03:38 Omega 3 Benefits01:05:26 Collagen Versus ProteinGain access to my new secret podcast, Unbreakable: The Runner's Guide To Injury-Proofing Your Body After 40. Click here: https://www.realliferunners.com/secretJoin the Team! -->  https://www.realliferunners.com/team Thanks for Listening!!Be sure to hit FOLLOW on Apple Podcasts, Spotify, or your favorite podcast player Leave a review on Apple Podcasts. Your ratings and reviews really help and we read each one!Come find us on Instagram and say hi! Don't forget: The information on this website is not intended to treat or diagnose any medical condition or to provide medical advice. It is intended for general education in the areas of health and wellness. All information contained in this site is intended to be educational in nature. Nothing should be considered medical advice for your specific situation.

This episode discusses the urgency for pharmacists to transition from using Cockcroft-Gault eCrCL to non-race based estimated glomerular filtration rate (eGFR) to improve medication-related decision-making in persons with reduced kidney function.  Listeners will learn how to transition from C-G eCrCL to eGFR adjusted for body surface area to improve medication effectiveness and safety in persons with chronic kidney disease. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/linksTesamorelin is one of the few peptides I've seen actually move the needle on body composition. So I made a full masterclass on it.This is the user's guide as it stands in 2026. I cover what tesamorelin is, how it works, and the best practices I'd recommend for using it.We get into the growth hormone axis and why a GHRH is different from a GHRP. I break down the clinical data, the 15% visceral fat reduction, the liver fat numbers, and the cognition research almost nobody talks about.Then we get practical. Dosing, timing, fasted injections, and the cycling patterns I actually use. I share why I stay at one milligram instead of two and what the water retention tradeoff looks like at higher doses.I also cover stacking with testosterone and GLP-1s, reconstitution, injection technique, side effects, and the people who should skip this one entirely.I'm honest about the limits too. Some of this evidence is strong and some of it isn't. I tell you which is which.If you're thinking about tesamorelin or already using it, this is everything I'd want you to know.

Send us Fan MailDr. Ian Justl Ellis is the Founder, CEO, and Lead Physician at Voafit. He specializes in helping individuals achieve their optimal physique while maintaining balance in their family, work, and social lives. His approach focuses on creating sustainable, real-world nutrition and exercise habits that can be maintained long-term without obsessive or unhealthy behaviors.Dr. Ellis has spent much of his life addressing what he describes as the "appetite problem." As a teenager determined not to follow the path of out-of-shape adults around him, he immersed himself in athletics, amateur bodybuilding, professional dance, and became a certified personal trainer. Despite achieving the desired outward appearance, he found himself caught in cycles of restriction, bingeing, and frustration.During medical school, marriage, and raising children simultaneously, he experienced significant personal weight gain and burnout, finishing residency sixty pounds overweight. In 2022, he was introduced to GLP-1 weight management medications, which helped address persistent hunger for the first time. However, using them in standard recommended dosing approaches resulted in muscle loss, weakness, and poor nourishment.In response, Dr. Ellis developed a precision-based approach to GLP-1 therapy that combines strength training, protein-first nutrition, hydration, and individualized dosing strategies. He also incorporated advanced peptide therapies to support hormonal optimization, muscle retention, and recovery.Website: Voafit.comUse code FA FOR 40% OFF Athletic greens is a non-negotiable part of my daily routine. With 75 absorbable vitamins and minerals in just one scoop a day, I have increased my energy, improved my immune function and so much more. To get your own AG at 20% off go to www.athleticgreens.com/functionallyautoimmune Order now for a free vitamin D3/K2 supplement and 5 free travel packs!Support the show

Most herbal dosing strategies fail during acute infections, not because the herbs are wrong, but because the dosage, frequency, and timing are wrong. In this video, Sajah Popham from the School of Evolutionary Herbalism walks you through the four biggest mistakes herbalists make when treating infections, and how to create protocols that lead to better outcomes. Here's what you'll learn: Why herbal dosing for acute infections is different from chronic care The four most common mistakes people make when taking herbs during illness Why low-dose strategies often fail in the treatment of acute infections Suggested dosage and frequency guidelines for acute herbal protocols Why herbs need time and consistency to build up and be effective How to think about various herb classes as part of your treatment protocol The importance of organ-system specificity and tissue state energetics Why herbs don't work the same way antibiotics do, and how to manage client expectations Treating lingering symptoms  Supportive lifestyle practices that improve recovery outcomes Warning signs that indicate it may be time to seek medical attention   If you want to dive even deeper into this kind of information, you might really like our FREE Vitalist Herbalism Mini-course.  Join the waitlist to get the FREE workshop when it starts on June 15, 2026: http://www.evolutionaryherbalism.com/vitalist-herbalism-mini-course/waitlist/   ———————————— CONNECT WITH SAJAH AND WHITNEY ———————————— To get free in depth mini-courses and videos, visit our blog at:  http://www.evolutionaryherbalism.com   Get daily inspiration and plant wisdom on our Facebook and Instagram channels: http://www.facebook.com/EvolutionaryHerbalism https://www.instagram.com/evolutionary_herbalism/   Be sure to subscribe to our YouTube Channel: https://www.youtube.com/channel/UCyP63opAmcpIAQg1M9ShNSQ   Get a free 5-week course when you buy a copy of the book, Evolutionary Herbalism: https://www.evolutionaryherbalism.com/evolutionary-herbalism-book/   Shop our herbal products:  https://naturasophiaspagyrics.com/   ———————————— ABOUT THE PLANT PATH ———————————— The Plant Path is a window into the world of herbal medicine. With perspectives gleaned from traditional Western herbalism, Ayurveda, Chinese Medicine, Alchemy, Medical Astrology, and traditional cultures from around the world, The Plant Path provides unique insights, skills and strategies for the practice of true holistic herbalism. From clinical to spiritual perspectives, we don't just focus on what herbs are "good for," but rather who they are as intelligent beings, and how we can work with them to heal us physically and consciously evolve.   ———————————— ABOUT SAJAH ———————————— Sajah Popham is the author of Evolutionary Herbalism and the founder of the School of Evolutionary Herbalism, where he trains herbalists in a holistic system of plant medicine that encompasses clinical Western herbalism, medical astrology, Ayurveda, and spagyric alchemy. His mission is to develop a comprehensive approach that balances the science and spirituality of plant medicine, focusing on using plants to heal and rejuvenate the body, clarify the mind, open the heart, and support the development of the soul. This is only achieved through understanding and working with the chemical, energetic, and spiritual properties of the plants. His teachings embody a heartfelt respect, honor and reverence for the vast intelligence of plants in a way that empowers us to look deeper into the nature of our medicines and ourselves. He lives on a homestead in the foothills of Mt. Baker Washington with his wife Whitney where he teaches, consults clients, and prepares spagyric herbal medicines.    ———————————— WANT TO FEATURE US ON YOUR PODCAST? ———————————— If you'd like to interview Sajah or Whitney to be on your podcast, click here to fill out an interview request form. If Whitney is facilitating an interview:   ———————————— ABOUT WHITNEY ———————————— Whitney Popham is an herbal practitioner and the co-founder of The School of Evolutionary Herbalism and Organic Unity. Her calling to plant medicine began from a deep passion for activism and a vision for creating healing and positive change in the world. She has devoted her life to that vision by being a humble vessel for the plants to touch people's lives and bring more healing and beauty into the world.   Through her own health challenges and struggles, she experienced the profound healing gifts of plant medicines and then committed her life to helping others reach vibrant levels of health. She specializes in digestive health in her clinical practice through working with herbal medicine, nutrition and lifestyle coaching. Her true gift is in listening to the plants through intuition and vision, which she uses to help her clients with healing on the emotional, psychological, spiritual, as well as physical levels of health.  

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You do the work. You train, you sleep, you eat well, you manage stress. And yet your joints still ache, recovery takes longer, and something just feels harder than it used to.I sit down with David Watumull, co-founder and CEO of AX3, to talk about astaxanthin, a naturally occurring antioxidant he has spent his entire career studying, one that most people have never heard of despite having more than 4,000 peer-reviewed papers and 100 human clinical trials behind it.This is not a conversation about the latest wellness trend. It's a deep look at the science of oxidative stress, chronic inflammation, and what actually happens inside your cells when the damage accumulates faster than your body can repair it.What we explore:- Why astaxanthin is categorically different from vitamins C and E, and how it works at every layer of the cell without ever becoming pro-oxidant.- How chronic inflammation starts with oxidative stress upstream, and why blocking it at the source is safer than suppressing the immune response after the fact.- Why this ingredient was one of only five agents in a 20-year NIH-funded program to extend mammalian lifespan by over 10 percent while also showing health span benefits.- How astaxanthin protects joints, muscles, and mitochondrial energy production, and what the data on competitive cyclists actually demonstrates.- What to look for in a supplement, why bioavailability determines whether you absorb anything at all, and how to build astaxanthin into a foundational daily stack.Chapters: 00:00 Intro03:30 Why Astaxanthin Isn't Like Other Antioxidants07:14 The Algae Origins of Astaxanthin11:22 Salmon, the Food Chain, and Nature's Design15:00 From Pharma Research to Supplement18:21 The NIH Longevity Study Explained23:15 mTOR, FOXO3, and the Aging Pathways29:10 Safe Anti-Inflammatory for Joints and Athletes35:15 Brain Protection and the Blood-Brain Barrier38:02 Skin Health and Sun Damage from the Inside45:00 Redox Balance and Liver Protection48:35 Mitochondria, Energy, and Endurance Performance53:00 How to Stack Astaxanthin with Other Supplements57:10 Dosing, Bioavailability, and What Sets AX3 Apart01:07:00 Why David Watumull Went All-In on One IngredientAbout David Watumull:David Watumull is the co-founder and CEO of AX3, a supplement company built on more than two decades of astaxanthin research. He was introduced to the ingredient as a teenager working on algae ponds on the Big Island of Hawaii, and has spent his career advancing its science through pharmaceutical-grade manufacturing, NIH-funded longevity studies, and peer-reviewed cardiovascular research. His work sits at the intersection of rigorous science and practical supplementation, and it shows.Connect with David Watumull:Instagram: https://www.instagram.com/davewatumull–This episode is sponsored by:AX3: Visit ax3.life and use code GABBY for 20% OFF your first orderWebsite: https://www.ax3.lifeInstagram: https://www.instagram.com/ax3.life–The Gabby Reece ShowThis is where I have real conversations with the people I find most worth listening to: scientists, athletes, coaches, parents, and thinkers who are doing the hard work of building a life that holds up over time. No hacks. No quick fixes. Just honest, practical conversations about performance, longevity, relationships, and what it actually takes to show up well at every age.If you are here, you probably already know that health is not a destination. It is how you live. I am glad you are along for it.Connect with Gabby Reece:Instagram: https://www.instagram.com/gabbyreece/TikTok: https://www.tiktok.com/@gabbyreeceofficialWebsite: https://gabriellereece.comPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most of the mushroom supplements you'll find on Amazon are ground-up fruiting bodies or myceliated grain in a capsule. AHCC is something entirely different. It's a patented fermented extract from shiitake mycelia that has been used in over 1,000 cancer clinics worldwide, backed by more than 100 published studies, and studied specifically for its effects on natural killer cells, HPV clearance, autoimmune conditions, and liver disease. I'd never heard of it until Mimi Lindquist introduced me to it. Lindquist is the co-founder of The Medicine alongside her husband, Chase. She started as a clinical dental hygienist in Seattle, where she observed firsthand how oral health mirrors systemic health, and eventually followed a thread from a patient's HPV recovery all the way to a research compound developed at the University of Tokyo in 1986. In this episode, Lindquist explains what AHCC actually is, how its manufacturing process makes it fundamentally different from any other mushroom product on the market, and why the clinical research behind it is unusually robust for a supplement. The mechanism that makes AHCC interesting is that it doesn't just boost the immune system indiscriminately. It modulates it. For healthy individuals with normal NK cell counts, it doesn't artificially raise them. For people dealing with HPV, cancerous tumors, or autoimmune conditions where the immune system needs more information, it does. This adaptogenic quality is why AHCC can support both an overactive immune response (as in autoimmune) and an underactive one (as in immune suppression from chronic illness or aging) without contradicting itself. I pushed back on this in the conversation because AHCC is a processed product that requires industrial manufacturing to produce, which doesn't fit neatly into an ancestral framework. Lindquist's response was honest: if we were living 100 years ago without microplastics, glyphosate in the rain, and the chronic stress loads of modern life, we probably wouldn't need it. But that's not the world we live in, and the thousands of testimonials she's received from people who had tried everything else and found relief with AHCC are hard to dismiss. Dosing is two capsules daily for general immune support, four for conditions like HPV, Lyme, or autoimmune, and six to eight for serious situations like tumors or advanced liver disease. Their product, Immune Intel AHCC, uses 750 milligrams per capsule with nothing else added. About Mimi Lindquist:  Meagan (Mimi) Lindquist is the co-founder of The Medicin, alongside her husband Chase. With her background as a clinical dental hygienist, culinary nutrition guide, and AHCC educator, she has been helping others prevent disease for over 12 years. Now, Mimi has dedicated herself entirely to sharing the benefits of Immune Intel AHCC, a mushroom supplement unlike any other, to as many people as possible. Instagram: https://www.instagram.com/mimi_themedicin/ Website: https://www.themedicin.com Podcast: https://feeds.captivate.fm/themedicin/ [Discount Code] Use code PRIMALSHIFT for 10% off Mimi's products → https://www.themedicin.com Thank you to this episode's sponsor, Peluva! Peluva makes minimalist shoes to support optimal foot, back and joint health. I started wearing Peluvas several months ago, and I haven't worn regular shoes since. I encourage you to consider trading your sneakers or training shoes for a pair of Peluvas, and then watch the health of your feet and lower back improve while reducing your risk of injury.  To learn more about why I love Peluva barefoot shoes, check out my in-depth review: https://michaelkummer.com/health/peluva-review/  And use code MICHAEL to get 10% off your first pair: https://michaelkummer.com/go/peluva  In this episode: 00:00 Intro  04:24 From dental health to holistic  07:47 Oral microbiome and inflammation  11:58 How AHCC entered her life  16:58 What AHCC actually is  19:17 Origins and NK cell research  28:13 Immune modulation explained  30:40 Fungal network intelligence  32:30 Primal vs processed supplements  36:15 Modern stress and immune support  40:10 Dosing for different needs  41:19 Kids and pets success stories  43:13 Industrial consistency vs foraging  47:37 How long until results  56:10 Final thoughts Find me on social media for more health and wellness content: Website: https://michaelkummer.com/ YouTube: https://www.youtube.com/@MichaelKummer Instagram: https://www.instagram.com/primalshiftpodcast/ Pinterest: https://www.pinterest.com/michaelkummer/ Twitter/X: https://twitter.com/mkummer82 Facebook: https://www.facebook.com/realmichaelkummer/ [Medical Disclaimer] The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health. [Affiliate Disclaimer] I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code.

Most people think tracking their protein is enough. The science says what your body actually craves is something far more specific and the person making that argument spent 23 years inside legacy media watching the wellness industry sell women everything from "bikini body in two weeks" to canned protein soda. In this episode, I sit down with Liz Plosser, former Editor in Chief of Women's Health, where she oversaw brands reaching 44 million women. We break down why the nine essential amino acids are what your body is really after when you chase protein, why BCAAs are only a fraction of the picture, and why a study found four of the top six creatine gummies on Amazon contained zero creatine. Liz also opens up about her own supplement stack, her shift from endurance running to heavy lifting, and makes the case that testing instead of guessing is one of the most empowering moves you can make for your health. Then we go deep on the science most people get wrong: why aging women struggle to pull amino acids from food, how essential aminos protect lean muscle even on rest days and for those on GLP-1s, the new research on high-dose creatine for sleep deprivation and Alzheimer's, and why collagen may not deserve the hype. We also cover the menopause misinformation epidemic, the 2002 hormone study that terrified the world, and what Liz puts in her own morning protocol. This conversation will completely change how you think about protein, what you supplement, and how you fuel your brain and body. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The Protein Myth and Why Amino Acids Are What Your Body Really Wants (00:00:56) Protein, Amino Acids, and How Much You Actually Need (00:03:23) The Nine Essential Amino Acids: The Real Building Blocks (00:06:03) BCAAs vs EAAs: Why a Subset Isn't Enough (00:11:50) 23 Years in Wellness Media: What Liz Saw Change (00:14:18) The Menopause Conversation and Why It Exploded (00:23:17) Kion Aminos, Timing, and Whether It Counts Toward Your 100g (00:26:46) Liz's Daily Routine: Aminos, Creatine, and the Morning Glass of Water (00:27:42) Can You Take Aminos While Fasting? (00:29:50) Do Aminos Preserve Lean Mass on Rest Days and on GLP-1s? (00:36:19) Leaving Legacy Media and Finding a New Mission (00:39:14) The New Creatine Research: Sleep, Dosing, and Alzheimer's (00:43:24) How Creatine Reaches the Brain and the Case for 10 Grams (00:44:48) Creatine for Mood and Depression (00:46:12) Collagen: Does It Actually Deserve the Hype? (00:49:40) The Creatine Gummy Scandal: Four of Six With Zero Creatine (00:51:27) Coffee, Cans, and Why Bioavailability Matters (00:54:50) Creatine, Electrolytes, and the 1990s Bodybuilding Hack (00:57:54) Liz's Morning Protocol and Owning Your AM _______ *Thank you to our sponsors*Function Health: https://www.functionhealth.com/louisanicolaTimeline: https://www.timeline.com/partners/neuro-athleticsAirDoctor: https://www.AirDoctorPro.com use promo code NEURO for up to $300 offQualia Life: https://www.qualialife.com/Neuro for an additional 15% off on top of the 50%BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.in... Learn more about your ad choices. Visit megaphone.fm/adchoices

Most people think tracking their protein is enough. The science says what your body actually craves is something far more specific and the person making that argument spent 23 years inside legacy media watching the wellness industry sell women everything from "bikini body in two weeks" to canned protein soda. In this episode, I sit down with Liz Plosser, former Editor in Chief of Women's Health, where she oversaw brands reaching 44 million women. We break down why the nine essential amino acids are what your body is really after when you chase protein, why BCAAs are only a fraction of the picture, and why a study found four of the top six creatine gummies on Amazon contained zero creatine. Liz also opens up about her own supplement stack, her shift from endurance running to heavy lifting, and makes the case that testing instead of guessing is one of the most empowering moves you can make for your health. Then we go deep on the science most people get wrong: why aging women struggle to pull amino acids from food, how essential aminos protect lean muscle even on rest days and for those on GLP-1s, the new research on high-dose creatine for sleep deprivation and Alzheimer's, and why collagen may not deserve the hype. We also cover the menopause misinformation epidemic, the 2002 hormone study that terrified the world, and what Liz puts in her own morning protocol. This conversation will completely change how you think about protein, what you supplement, and how you fuel your brain and body. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The Protein Myth and Why Amino Acids Are What Your Body Really Wants 00:56 Protein, Amino Acids, and How Much You Actually Need 03:23 The Nine Essential Amino Acids: The Real Building Blocks 06:03 BCAAs vs EAAs: Why a Subset Isn't Enough 11:50 23 Years in Wellness Media: What Liz Saw Change 14:18 The Menopause Conversation and Why It Exploded 23:17 Kion Aminos, Timing, and Whether It Counts Toward Your 100g 26:46 Liz's Daily Routine: Aminos, Creatine, and the Morning Glass of Water 27:42 Can You Take Aminos While Fasting? 29:50 Do Aminos Preserve Lean Mass on Rest Days and on GLP-1s? 36:19 Leaving Legacy Media and Finding a New Mission 39:14 The New Creatine Research: Sleep, Dosing, and Alzheimer's 43:24 How Creatine Reaches the Brain and the Case for 10 Grams 44:48 Creatine for Mood and Depression 46:12 Collagen: Does It Actually Deserve the Hype? 49:40 The Creatine Gummy Scandal: Four of Six With Zero Creatine 51:27 Coffee, Cans, and Why Bioavailability Matters 54:50 Creatine, Electrolytes, and the 1990s Bodybuilding Hack 57:54 Liz's Morning Protocol and Owning Your AM _______ Thank you to our sponsors Function Health: https://www.functionhealth.com/louisanicola Timeline: https://www.timeline.com/partners/neuro-athletics AirDoctor: https://www.AirDoctorPro.com use promo code NEURO for up to $300 off Qualia Life: https://www.qualialife.com/Neuro for an additional 15% off on top of the 50% BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us Fan MailOne infant is diagnosed with neonatal opioid withdrawal syndrome every 27 minutes, and rates are rising. In this episode of Journal Club, Ben and Daphna review the Optimized NOW randomized clinical trial, a landmark multicenter study published in JAMA. The trial compared symptom-based dosing,  a single opioid dose given when a withdrawal threshold is met against the traditional scheduled opioid taper in infants managed with Eat Sleep Console. The results are striking: symptom-based dosing reduced time to medical readiness for discharge by nearly two and a half days, and 65% of pharmacologically treated infants avoided scheduled opioid dosing entirely. Could this be the evidence-based approach that finally reshapes how we treat NOWS pharmacologically?----Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial. Devlin LA et al HEAL Evaluation of Limited Pharmacotherapies for Neonatal Opioid Withdrawal Syndrome (HELP for NOWS) Consortium.JAMA. 2026 Apr 25:e265782. doi: 10.1001/jama.2026.5782. Online ahead of print. PMID: 42033722Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!

The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show. Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up. You'll Learn: Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70 Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one Thank you to our sponsors! - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity Resources: • Go to timeline.com/Dave or just use code ‘Dave' to get 20% off your next order. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:37 – Intro 03:57 – Pomegranates 10:03 – Discovering Urolithin A & Mitophagy 20:50 – Science vs. Pomegranate Supplements 25:24 – Topical Skincare Science 26:09 – L'Oreal Partnership & Skin Results 33:38 – 15 Clinical Studies & XPRIZE 43:50 – Nature Aging Immune Study 49:22 – Dosing & Daily Routine 51:29 – Future of Mitochondrial Health See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Stephanie Estima gives a masterclass on the often-overlooked role of lactate in how our bodies work during exercise. She's redefining lactate as a key metabolic signal that can help us get stronger, age better and think sharper. In this solo episode, Dr. Stephanie gets into how lactate is made, how it fuels our energy and why it's so important when we push ourselves hard. Dr. Stephanie is a big fan of sprinting because it helps us build metabolic power and stay strong, and she'll also talk about how to use it right and how to recover well. Episode Overview: (0:00) Introduction — Lactate Is Not the Enemy (2:15) Welcome & Episode Roadmap (4:30) The Myth: How We Got Lactate Wrong (7:00) What Lactate Actually Is (The Biochemistry) (9:30) Why Lactate Forms Even With Oxygen (15:00) The Gear Analogy — Don't Be Metabolically Polite (18:00) Metabolic Flexibility & Why HIIT Matters (22:00) How to Dose Your Sprints (Beginner to Advanced) (24:30) The Lactate Shuttle — Redistribution, Not Waste (28:30) Mitochondrial Biogenesis & Longevity Signals (32:00) Lactate and Your Brain — BDNF, Fog & Cognitive Edge (38:30) Dosing, Recovery Rules & Programming (46:00) Closing — You Are Remodelling Yourself Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep469 We couldn't do it without our sponsors: BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. MUSE - Train your nervous system with feedback, the same way you'd train muscles with resistance. If you are ready to unlock your brain's potential, go to https://choosemuse.com/BETTER or use code BETTER at checkout to get started. PIQUE LIFE - If you want to redefine your afternoon and evening rituals and still feel like yourself the next day, you can get 10% off at https://piquelife.com/better TIMELINE   - Timeline's clinically proven formula is now available at a new, lower price . Mitopure now starts at $79, when you go to https://timelinenutrition.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Blood Sweat & Gear dives into TRT, Trestolone, carb loads, GH testing, Masteron & estrogen, Melanotan 2, cutting strategies, and real coaching insight from experienced bodybuilding coaches. We break down physique critiques, off-season nutrition, health support supplements, and what really matters for progress on cycle and in prep. Featuring Scott McNally and the crew discussing bodybuilding, PEDs, coaching, contest prep, and the science behind getting bigger, leaner, and healthier. 0:00 Intro & Listener Questions 1:00 Trestolone (MENT) as TRT Instead of Testosterone? 4:30 How Top Coaches Use High Days in a Diet 9:00 How to Calculate the Perfect Carb Load 11:45 The Most Important Part of Great Coaching 15:30 Using High Days During the Off Season 19:30 Do Taller Bodybuilders Need More Gear? 24:30 Should You Test GH Labs While Using Growth Hormone? 28:50 300 Test + 300 Masteron — Estimating Estrogen Levels 35:00 Sending PED Samples to Janoshik Explained 36:30 Melanotan 2 Protocols, Dosing & Results 40:45 Should There Be a Coaching Review Website? 44:30 Best Training Tips While Cutting Calories 50:10 Do You Need Health Supplements During a Cruise? 56:00 Live Physique Critique & Feedback 1:03:45 Behind the Schedule & Podcast Talk 1:05:30 Why Everything at Think Big Is Eccentric 1:07:00 Ms. Olympia Joins the Chat 1:10:40 Scott McNally's Client Competing in Germany