Podcasts about Dosing

18-year-olds wake up fresh because their repair system still works. This episode shows you how stem cell decline quietly drives fatigue, inflammation, and faster aging, and how fasting can reactivate your body's natural ability to repair itself without expensive stem cell procedures. Grab a generous 30% discount on any STEMREGEN product with: http://stemregen.co/dave30 Dave Asprey sits down with Christian Drapeau, a neuroscientist trained at McGill University and a leading researcher in stem cell science. Christian pioneered a therapeutic approach called Endogenous Stem Cell Mobilization, authored the bestselling book Cracking the Stem Cell Code, and developed the concept of stem cell enhancement. He is the Founder and CSO of STEMREGEN, where his work focuses on helping the body release and use its own stem cells more effectively. Together, they break down why many injected stem cells never survive long enough to help, how the lungs trap a large percentage of IV stem cells, and why releasing your own stem cells into arterial circulation changes the outcome. They explore stem cell decline as a core driver of aging, tissue degeneration, and chronic inflammation, and explain why fasting is currently the only intervention shown to rejuvenate stem cells through autophagy. You'll hear why a three-day fast has measurable effects on bone marrow aging, how stem cells act as signaling molecules that coordinate repair across the body, and why mitochondria play a massive and underappreciated role in stem cell renewal and tissue regeneration. The conversation also covers scar tissue, fibrosis, recovery from injury, and why healing quality matters just as much as healing speed. You'll Learn: • Why stem cell decline, not simple wear and tear, drives aging • How fasting supports stem cell rejuvenation through autophagy • Why many injected stem cells die in the lungs before helping tissue • How releasing your own stem cells differs from IV stem cell therapy • Why mitochondria are central to stem cell function and repair • How scar tissue and fibrosis form when repair fails • Why recovery quality determines long-term resilience and longevity Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. • Generation Lab | Go to http://generationlab.com/, use code DAVE20 for $20 off, and see what your body's really doing behind the surface. • Puori | Use code DAVE at https://puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: stem cell longevity, fasting stem cell rejuvenation, three day fast science, biohacking stem cells, endogenous stem cell mobilization, stem cell decline aging, autophagy fasting longevity, mitochondria stem cells, tissue repair aging, inflammation and aging science, functional medicine longevity podcast, human performance longevity, anti-aging fasting protocol, metabolism and aging, ketosis fasting science, supplements longevity debate, Dave Asprey longevity, Christian Drapeau stem cells, biohacking podcast longevity Resources: • Learn More About Everything STEMREGEN at: http://stemregen.co/dave30 • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 — Trailer 1:20 — Stem Cell Basics & IV vs Release 7:41 — Bone Marrow Conversion & Fasting 11:01 — Stem Cell Decline vs Exhaustion 12:39 — Releasing Stem Cells 14:01 — Stem Cells as Signaling Molecules 18:13 — Stacking Interventions 23:31 — Dosing & Duration 40:42 — Daily Repair & Deficits 48:20 — Resilience & Testing 53:17 — Inflammation as Signal 57:45 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A 2022 meta-analysis of 37 randomized trials found that berberine lowered glycated hemoglobin by 0.63% and fasting glucose by 0.82 mmol/L, with consistent results across diverse patient groups Earlier researchers also highlighted how berberine lowers blood sugar and harmful blood fats while also reducing liver fat and markers linked to kidney damage Berberine limits fat cell development and dampens inflammation as well, effects that may support weight control and improved insulin sensitivity In a 13‑week randomized study, researchers showed that berberine's blood sugar-lowering abilities are on par with the effects of the diabetes drug metformin Clinical studies support taking 500 mg of berberine with meals up to three times daily, starting with lower doses and increasing gradually; however, there are safety precautions to keep in mind

🧭 REBEL Rundown 🗝️ Key Points 💉 Hydrocortisone Saves Lives:The 2023 Cape Cod Trial (NEJM) showed a clear mortality benefit and reduced need for intubation in severe CAP patients treated with hydrocortisone.📊 Guidelines Are Catching Up:The SCCM (2024) and ERS now recommend steroids for severe CAP, while ATS/IDSA updates are still pending.🔥 Redefining “Severe”:Patients requiring high FiO₂ (>50%), noninvasive or mechanical ventilation, or PSI >130 meet criteria for steroid therapy — even outside the ICU.🍬 Main Risk = Hyperglycemia:Elevated glucose was the most consistent adverse effect, but rates of GI bleed and secondary infection were not increased.🧭 Early, Targeted Use Matters:Start hydrocortisone within 24 hours of identifying severity — especially in patients with high CRP (>150) or strong inflammatory response. Click here for Direct Download of the Podcast. 📝 Introduction Corticosteroids have long sparked debate in the treatment of bacterial pneumonia — once viewed with skepticism, now increasingly supported by high-quality evidence. In this episode, Dr. Alex Chapa joins the REBEL Core Cast team to explore how the 2023 Cape Cod Trial (NEJM) reshaped practice and guideline recommendations for severe community-acquired pneumonia (CAP). 📖 Historical Context & Long-Standing Skepticism For decades, the use of steroids in pneumonia was controversial.Early Use: Steroids entered practice in the 1940s and 50s for autoimmune inflammation, but there was immediate hesitation regarding secondary superinfections.Mixed Data: From the 1980s to the 2000s, small studies emerged on severe pneumonia and ARDS, but the data was inconsistent. Different trials used varying definitions of “severe” pneumonia and different C-reactive protein (CRP) cutoffs, making the data “spread” and easy to “cherry pick” to support or deny a benefit.Past Guidelines: This uncertainty was reflected in official guidelines:2007 (ATS/IDSA): The American Thoracic Society and the Infectious Diseases Society of America did not address the topic due to insufficient data.2019 (ATS/IDSA): Pre-COVID, the guidelines recommended against using corticosteroids in severe CAP. They acknowledged no benefit for non-severe pneumonia, but the data for severe pneumonia was considered too weak to endorse.Pre-Trial Consensus: Prior to 2023, the consensus was to avoid steroids in non-severe pneumonia, while severe pneumonia remained a “gray area” with no treatment showing a clear mortality difference. 📜 The Landmark Cape Cod Trial (NEJM 2023) The Cape Cod trial, published in the New England Journal of Medicine in 2023, reignited the discussion by providing robust, positive data.Trial Design: Phase 3, multi-center, double-blind, randomized, controlled trial.Intervention: 800 patients randomized to two groups, Hydrocortisone as a continuous infusion (200mg/day) versus a placebo infusion.Taper: On day 4, clinicians would decide whether to continue the infusion or begin a taper based on clinical response.Population: Patients with severe CAP, defined by meeting at least one of the following criteria:Pneumonia Severity Index (PSI) > 130.O2 by FiO2 ratio < 300.Need for mechanical or non-invasive ventilation (with PEEP ≥ 5).Need for high FiO2 (>50%) via non-rebreather or heated high flow.Primary Outcomes: Death for any cause 6.2% (hydrocortisone) vs 11.9% (placebo)Secondary outcomes:Death from any cause at 90 days 9.3% (hydrocortisone) vs 14.7% (placebo)Endotracheal intubation 18% (hydrocortisone) vs 29% (placebo)Hospital-acquired infections 9.8% (hydrocortisone) vs 11.1% (placebo)Gastrointestinal bleeding 2.3% (hydrocortisone) vs 3.3% (placebo)Vasopressor initiation by day 28 15.3% (hydrocortisone) vs 25.0% (placebo)Key Findings: The trial demonstrated superiority for hydrocortisone 📋 Updated Guidelines & Current Practice The Cape Cod trial, along with subsequent meta-analyses, has begun to change official recommendations.Society of Critical Care Medicine (SCCM): In 2024, an SCCM expert panel, reviewing the Cape Cod trial and 18 others, strongly recommended corticosteroids for severe CAP. They concluded that steroids reduce mortality and the need for mechanical ventilation.Meta-Analysis (Smit et al.): A 2024 meta-analysis in Lancet Respiratory confirmed the 30-day mortality benefit.European Respiratory Society (ERS): The ERS has issued a recommendation to use steroids for severe pneumonia but still urges caution regarding side effects.ATS/IDSA: As of the podcast recording, the ATS/IDSA had not yet updated their 2019 guidelines. 🛠️ Practical Application for Clinicians Defining “Severe” CAP: The key is to identify patients who qualify as “severe”. This can be done using:Scoring Tools: The PSI is the best validated tool for mortality but is cumbersome. Simpler tools like CURB-65 or SMART-COP are practical and acceptable for defining severity. 2023 meta-analysis from by Zaki et al showed both work well, but CURB-65 has better mortality prediction early on.Cape Cod Criteria: Any patient meeting the trial’s inclusion criteria (e.g., high-flow O2, non-invasive ventilation) qualifies, regardless of location (ED, floor, or ICU).Biomarkers: While not required, a CRP level was used in many studies. A CRP > 150 (Cape Cod) or > 204 (Smit meta-analysis) strongly indicates severe inflammation that would benefit from steroids.Clinical Judgment: A patient who looks “sick,” has “soft” blood pressure, or has dense infiltrates and high oxygen needs (e.g., >50% FiO2 on high flow) is a candidate.Adverse Effects:Hyperglycemia: This was the most significant risk identified, with rates between 6-12%. This is a primary concern, especially in patient populations with high BMI.GI Bleed & Secondary Infection: Fears of these side effects, which contributed to historical skepticism, were not borne out in the Cape Cod trial. The data does not support being overly concerned.Other Side Effects: Mood changes, delirium, insomnia, and agitation in the elderly are known side effects of steroids that were not specifically addressed in the trial but remain clinical concerns. 🔄 Clinical Pathway for Steroids in Severe CAP Unanswered Questions & Future Research Possible remaining questions:Biomarkers: Can we find a more precise CRP level to distinguish moderate from severe disease? Could other markers like ferritin or IL-6 be used? Dosing & Tapering: How much immunomodulation is needed, and when is it truly safe to taper?Gender Differences: Early data suggests females may respond better to steroids and experience fewer side effects. The question of female patients with severe CAP require less corticosteroids needs further exploration. 👉 Clinical Bottom Line The current literature, spearheaded by the Cape Cod trial, now supports the use of corticosteroids in severe community-acquired pneumonia. The best evidence currently points to hydrocortisone, started early (within 24 hours) after severity is identified using a validated tool. While hyperglycemia is a risk, the previous fears of GI bleeding and secondary infections were not substantiated in recent, rigorous trials. 📚 References Chapa-Rodriguez A, Abou-Elmagd T, O’Rear C, Narechania S. Do patients with severe community-acquired bacterial pneumonia benefit from systemic corticosteroids?. Cleve Clin J Med. 2025;92(10):600-604. PMID: 41033846Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;388(21):1931-1941. PMID: 36942789Chaudhuri D, Nei AM, Rochwerg B, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e233. PMID: 38240492 Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Alex Chapa, MD PGY 5 Pulmonary Critical Care Fellow Cape Fear Valley Medical Center Fayetteville NC 🔎 Your Deep-Dive Starts Here REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia Corticosteroids have long sparked debate in the treatment of bacterial ... Thoracic and Respiratory Read More The post REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia appeared first on REBEL EM - Emergency Medicine Blog.

Drs. Ted Morton and Christine Lockowitz join Dr. Ryan Moenster to discuss all things amoxicillin, particularly in our pediatric patients. Our guests answer common questions, such as, what formulations should be used for certain infectious conditions and/or organisms and how to dose amoxicillin to maximize PK/PD optimization without inducing potential adverse events. It is a must-listen for all! This episode also qualifies for 1 hour of BCIDP credit! How to Obtain BCIDP Recertification Credit for this Episode: Visit sidp.org/BCIDP for more information. References: Bradley JS, Garonzik SM, Forrest A, Bhavnani SM. Pharmacokinetics, pharmacodynamics, and Monte Carlo simulation: selecting the best antimicrobial dose to treat an infection. Pediatr Infect Dis J. 2010 Nov;29(11):1043-6. doi: 10.1097/INF.0b013e3181f42a53. PMID: 20975453. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2. doi: 10.1086/516284. PMID: 9455502. Hakenbeck R, Grebe T, Zähner D, Stock JB. beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins. Mol Microbiol. 1999 Aug;33(4):673-8. doi: 10.1046/j.1365-2958.1999.01521.x. PMID: 10447877. Bax R. Development of a twice daily dosing regimen of amoxicillin/clavulanate. Int J Antimicrob Agents. 2007 Dec;30 Suppl 2:S118-21. doi: 10.1016/j.ijantimicag.2007.09.002. Epub 2007 Nov 5. PMID: 17983732. Bielicki JA, Stöhr W, Barratt S, Dunn D, Naufal N, Roland D, Sturgeon K, Finn A, Rodriguez-Ruiz JP, Malhotra-Kumar S, Powell C, Faust SN, Alcock AE, Hall D, Robinson G, Hawcutt DB, Lyttle MD, Gibb DM, Sharland M; PERUKI, GAPRUKI, and the CAP-IT Trial Group. Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial. JAMA. 2021 Nov 2;326(17):1713-1724. doi: 10.1001/jama.2021.17843. Erratum in: JAMA. 2021 Dec 7;326(21):2208. doi: 10.1001/jama.2021.20219. PMID: 34726708; PMCID: PMC8564579.

Where are you listening from?The best cannabis stories rarely start perfect. Wayne's first brownie was straight ground flower in batter, woody and weak, made in a tiny farm town with zero guidance. Today, his routine is dialed: jar-decarbed flower for richer terpenes, tiny eight-gram cookies for precise microdosing, and a simple rule that keeps him sharp, minimum effective dose, maximum benefit.We go deep on how edibles can replace alcohol without sacrificing fun or focus, dismantle the lazy stoner myth with real habits and talk community, access, and why walking into a dispensary is less urgent when your kitchen and garden already deliver what you need.If you're chasing smoother pain relief, clearer focus, or a social swap for booze, this conversation gives you tools, not hype. Come for the confessions, stay for the techniques you can use tonight.Find the guide on Amazon in paperback or Kindle and do a t-break when you're ready! Science shows even a short break can be helpful!Support the show Visit the website for full show notes, free dosing calculator, recipes and more.

Dr. Rupsa Boelig, a 2025 March of Dimes Discovery Research Grant winner and an Associate Professor of Obstetrics and Gynecology in the Division of Maternal Fetal Medicine at Philadelphia's Thomas Jefferson University, discusses her new study on the metabolism of aspirin in pregnant women with diabetes or a higher BMI. She hopes the study findings will shed light on whether these women may benefit from a higher aspirin dose to help prevent preeclampsia and/or preterm birth.

Watch Here : https://www.youtube.com/watch?v=kEVOAP6nvLg Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve

Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Theodore Achacoso and Boomer Anderson, leaders in Health Optimization Medicine and Practice. Dr. Achacoso is a physician-scientist and the founding pioneer of Health Optimization Medicine, known for his work on cellular networks, metabolomics, and mitochondrial function. Boomer Anderson is the CEO of Smarter Not Harder and Troscriptions, where he focuses on translating complex biology into practical tools for human performance and longevity. Together, they unpack how cells respond to perceived threats through the Cell Danger Response, why mitochondria control energy, inflammation, and repair, and why chasing disease labels misses the real drivers of aging. The discussion covers methylene blue as an electron recycler, why LDL cholesterol plays a role in detoxification and immune signaling, how fasting and ketosis shift metabolism between repair and growth, and why sleep optimization, circadian rhythm, and light exposure matter even more when you travel. They also explore neuroplasticity, consciousness, nootropics, supplements, and why health optimization works best when you restore balance instead of forcing outcomes. You'll Learn: • What the Cell Danger Response is and how it reshapes aging and performance • How mitochondria sense stress before symptoms appear • Why cellular energy controls resilience, sleep, and longevity • How methylene blue supports mitochondrial electron flow • Why fasting and ketosis shift metabolism between repair and growth • How travel, light, and circadian disruption affect aging • Why very low LDL can impair detoxification and immune signaling • Why real anti-aging starts at the cellular level, not with disease labels Thank you to our sponsors! AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. Screenfit | Get your at-home eye training program for 40% off using code DAVE at www.screenfit.com/dave. Puori | Use code DAVE at puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cell danger response podcast, mitochondria aging, mitochondrial dysfunction aging, health optimization medicine, dr ted achacoso, boomer anderson, troscriptions, troscriptions methylene blue, methylene blue mitochondria, methylene blue biohacking, cellular aging podcast, anti aging mitochondria, metabolic stress aging, fasting ketosis metabolism, mitochondrial energy production, neuroplasticity mitochondria, sleep optimization aging, functional medicine mitochondria, smarter not harder biohacking, dave asprey mitochondria Resources: • Get A Discount On All Troscription Products with code ‘dave' at: https://troscriptions.com/ • Learn More About Methylene Blue From My Full Masterclass Covering The Topic: https://daveasprey.com/mb/ • Discover More About The ‘Health Optimization Medicine and Practice' From Our Guests: https://homehope.org/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:25 – Introduction & Guest Background 3:11 – Health Optimization Medicine Origins 4:26 – Root Causes of Health vs Disease 6:15 – Biohacking & Self-Experimentation 8:19 – Medicinal Plants & Nootropics 11:25 – Travel & Jet Lag Solutions 13:42 – Cell Danger Response 17:38 – Metabolites & Cellular Health 18:57 – LDL & Lipopolysaccharides 20:42 – Cellular Model & First Principles 22:55 – Consciousness & Mitochondria 25:46 – Nanotechnology Research 28:55 – Giving Back & Service 31:17 – Blue Cannatine Development 34:48 – Methylene Blue Products 36:22 – Metformin Discussion 38:00 – Dosing & Cordycepin 41:25 – Closing & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Key Episode TakeawaysOral Wegovy is real, but it's not “just a pill version of the shot.” Absorption rules, dosing schedules, and patient selection matter a lot more than most headlines suggest.Switching from injections to oral GLP-1s requires a plan. The transition isn't one-size-fits-all, and dose timing, GI tolerance, and expectations need to be managed carefully.Weight regain after stopping GLP-1s is common, but not universal. SURMOUNT-4 data shows large variability, reinforcing that biology, not willpower, drives outcomes.Maintenance matters as much as weight loss. Some patients need continued therapy at lower doses, while others may maintain with lifestyle plus strategic medication use.Stopping abruptly is usually the worst approach. Gradual transitions and realistic long-term strategies reduce rebound weight gain.GLP-1s are chronic disease tools, not short-term fixes. Treating obesity like hypertension or diabetes leads to better outcomes and fewer surprises. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

A highlight from exceptional sessions at the 2025 Midyear Clinical Meeting & Exhibition, this podcast explores dosing conundrums specific to agents in oncology chemotherapy, antimicrobials, and therapeutic heparin use in over and underweight patients. Listeners will understand the complexity given conflicting data and receive guidance for dosing considerations to implement in clinical practice.  The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

On this episode of Vitality Radio, Jared St. Clair explains why supplement companies and their labels—and even educators like Jared—have to sound so careful about the claims they make. You'll learn how DSHEA (the Dietary Supplement Health and Education Act) reshaped the supplement industry in the 1990s, why brands can say “supports healthy joints” but can't say “treats arthritis,” and what “structure/function claims” really mean. Jared also breaks down the FDA-required disclaimer (“These statements have not been evaluated…”) so you know what it does and doesn't imply about whether a product works. Finally, he gives a practical label-reading skill most shoppers miss: serving size math, so you can tell what you're actually getting per capsule and per day.Additional Information:Vitamin Raid YouTube VideoEpisode BlogInventory Reduction Sale!For the first time ever, we're bringing to you our inventory reduction sale online. Over 200 trusted products are already deeply discounted, including clearance items, overstock, and some short-dated products (all still in date). On top of the markdowns, the more you buy, the more you save, with stacked discounts that can reach up to 70–80% off retail. This sale runs through January 31st or while supplies last—when it's gone, it's gone. Shop Here!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you'll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Renteln, Co Founder and CEO of LUCY Nicotine, a company pioneering science led alternatives for adult nicotine users who want better options. Before launching LUCY, David was also a co founder of Soylent, where he helped pioneer new approaches to functional nutrition and metabolism. Together, Dave and David break down how nicotine works in the brain through acetylcholine and dopamine, why speed of absorption determines addiction risk, and how nicotine affects learning, memory, motivation, and mood. The conversation also covers sleep optimization, mitochondrial signaling, tolerance, cycling strategies, and why modern regulation often slows innovation in functional medicine, anti aging science, and human performance.You'll Learn: • Why nicotine itself is not the same as smoking or vaping • How delivery speed changes addiction risk and brain response • How nicotine supports learning, focus, and neuroplasticity • Why acetylcholine matters for memory and brain optimization • How to think about dosing, cycling, and tolerance safely • How nicotine stacks with caffeine, nootropics, and Danger Coffee • The relationship between nicotine, sleep architecture, and REM • Why harm reduction matters for longevity and mitochondrial health • How nicotine fits into a Smarter Not Harder biohacking strategy Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -Lucy! Get a 20% discount by using code ‘Dave' at https://lucy.co/# Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nicotine podcast, nicotine nootropic, oral nicotine benefits, nicotine brain optimization, nicotine acetylcholine dopamine, nicotine learning memory, nicotine addiction risk, nicotine pouches vs smoking, LUCY nicotine, david renteln lucy, david renteln nicotine, lucy nicotine pouches, harm reduction nicotine, nicotine biohacking, nicotine human performance, nicotine longevity, nicotine neuroplasticity, nicotine sleep optimization, nicotine tolerance cycling, caffeine nicotine stack, danger coffee nicotine, dave asprey nicotine, dave asprey lucy, nootropics nicotine, functional medicine nicotine Resources: • HeartMath | Go to https://www.heartmath.com/dave to save 15% off. • LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:10 – Origin Story 2:20 – Product Forms & Usage 3:52 – Effects & Mechanisms 9:21 – Dosing & Addiction 15:33 – Memory & Cognitive Benefits 18:57 – Personality & Stacking 21:41 – Quitting Smoking 24:39 – Government Regulation 32:00 – Addiction Philosophy 35:30 – Behavior Change & Routines 39:08 – Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, we explore pharmacogenetics-guided dosing strategies with Dr. Chris Aiken. What if your patient's treatment failure isn't about the wrong medication, but the wrong dose? Discover how genetic testing reveals whether patients are poor or rapid metabolizers and learn the specific dosing adjustments that can transform outcomes. Faculty: Chris Aiken, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 0.75 CME: The Role of Genetic Testing in Psychiatry Pharmacogenetics-Guided Dosing: Strategies for Poor and Rapid Metabolizers

Testosterone therapy in women remains one of the most misunderstood and inconsistently applied areas of hormone care. Unlike men, women do not have FDA-approved testosterone products, making dosing strategy and delivery method critical to both safety and effectiveness. In this video, I review the clinical evidence behind testosterone pellet dosing in women, explain how pellets compare to topical gels, and clarify why outcomes depend far more on dose, pharmacokinetics, and monitoring than on the delivery method itself. Drawing from published consensus statements, clinical studies, and real-world patient data, I address: Why standardized testosterone options exist for men, but not for women How testosterone pellets are dosed safely in clinical practice What research shows about absorption, variability, and blood levels How to interpret testosterone labs in women Why precision matters when approved products are unavailable This discussion is informed by the General Consensus Position Statement on the Use of Testosterone for Women (Climacteric, 2019), which outlines the evidence base, indications, and limitations of testosterone therapy in women.

Luke Hedrick, Dave Furfaro, and recurrent RFJC guest Robert Wharton are joined again today by Nicole Ng to discuss the FIBRONEER-IPF trial investigating Nerandomilast in patients with IPF. This trial was published in NEJM in 2025 and looked at Neradomilast vs placebo for treating patients with IPF, on or off background anti-fibrotic therapy. This agents is now FDA approved for pulmonary fibrosis, and understanding the trial results is essential for any pulmonary physician treating patients with IPF or progressive pulmonary fibrosis. Article and Reference Today’s episode discusses the FIBRONEER-IPF trial published in NEJM in 2025. Richeldi L, Azuma A, Cottin V, Kreuter M, Maher TM, Martinez FJ, Oldham JM, Valenzuela C, Clerisme-Beaty E, Gordat M, Wachtlin D, Liu Y, Schlecker C, Stowasser S, Zoz DF, Wijsenbeek MS; FIBRONEER-IPF Trial Investigators. Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis. N Engl J Med. 2025 Jun 12;392(22):2193-2202. doi: 10.1056/NEJMoa2414108. Epub 2025 May 18. PMID: 40387033. https://www.nejm.org/doi/abs/10.1056/NEJMoa2414108 Meet Our Guests Luke Hedrick is an Associate Editor at Pulm PEEPs and runs the Rapid Fire Journal Club Series. He is a senior PCCM fellow at Emory, and will be starting as a pulmonary attending at Duke University next year. Robert Wharton is a recurring guest on Pulm PEEPs as a part of our Rapid Fire Journal Club Series. He completed his internal medicine residency at Mt. Sinai in New York City, and is currently a pulmonary and critical care fellow at Johns Hopkins. Dr. Nicole Ng is an Assistant Profess of Medicine at Mount Sinai Hospital, and is the Associate Director of the Interstitial Lung Disease Program for the Mount Sinai National Jewish Health Respiratory Institute. Infographic Key Learning Points Why this trial mattered IPF therapies remain limited: nintedanib and pirfenidone slow (but do not stop) decline and often cause GI side effects. Nerandomilast is a newer agent (a preferential PDE4B inhibitor) with antifibrotic + immunomodulatory effects. Phase 2 data (NEJM 2022) looked very promising (suggesting near-“halt” of FVC decline), so this phase 3 trial was a big test of that signal. Trial design essentials Industry-sponsored, randomized, double-blind, placebo-controlled, large multinational study (332 sites, 36 countries). Population: IPF diagnosed via guideline-aligned criteria with central imaging review and multidisciplinary diagnostic confirmation. Intervention: nerandomilast 18 mg BID, 9 mg BID, or placebo; stratified by background antifibrotic use. Primary endpoint: change in FVC at 52 weeks, analyzed with a mixed model for repeated measures. Key secondary endpoint: time to first acute exacerbation, respiratory hospitalization, or death (composite). Who was enrolled Typical IPF trial demographics: ~80% male, mean age ~70, many former smokers. Many were already on background therapy (~45% nintedanib, ~30–33% pirfenidone). Notable exclusions included significant liver disease, advanced CKD, recent major cardiovascular events, and psychiatric risk (suicidality/severe depression), reflecting class concerns seen with other PDE4 inhibitors. Efficacy: what the primary endpoint showed Nerandomilast produced a statistically significant but modest reduction in annual FVC decline vs placebo (roughly 60–70 mL difference). Importantly, it did not halt FVC decline the way the phase 2 data suggested; patients still progressed. Important nuance: interaction with pirfenidone Patients on pirfenidone had ~50% lower nerandomilast trough levels. Clinically: 9 mg BID looked ineffective with pirfenidone, so 18 mg BID is needed if used together. In those not on background therapy or on nintedanib, 9 mg and 18 mg looked similar—suggesting the apparent “dose-response” might be partly driven by the pirfenidone drug interaction Secondary and patient-centered outcomes were neutral No demonstrated benefit in the composite outcome (exacerbation/resp hospitalization/death) or its components. Quality of life measures were neutral and declined in all groups, emphasizing that slowing FVC alone may not translate into felt improvement without a disease-reversing therapy. The discussants noted this may reflect limited power/duration for these outcomes and mentioned signals from other datasets/pooling that might suggest mortality benefit—but in this specific trial, the key secondary endpoint was not positive. Safety and tolerability Diarrhea was the main adverse event: Higher overall with the 18 mg dose, and highest when combined with nintedanib (up to ~62%). Mostly mild/manageable; discontinuation due to diarrhea was relatively uncommon (but higher in those on nintedanib). Reassuringly, there was no signal for increased depression/suicidality/vasculitis despite psychiatric exclusions and theoretical class risk. How to interpret “modest FVC benefit” clinically The group framed nerandomilast as another tool that adds incremental slowing of progression. They emphasized that comparing absolute FVC differences across trials (ASCEND/INPULSIS vs this trial) is tricky because populations and “natural history” in placebo arms have changed over time (earlier diagnosis, improved supportive care, etc.). They highlighted channeling bias: patients already on antifibrotics may be sicker (longer disease duration, lower PFTs, more oxygen), complicating subgroup comparisons. Practical takeaways for real-world use All three antifibrotics are “fair game”; choice should be shared decision-making based on goals, tolerability, dosing preferences, and logistics. Reasons they favored nerandomilast in practice: No routine lab monitoring (major convenience advantage vs traditional antifibrotics). Generally better GI tolerability than nintedanib. BID dosing (vs pirfenidone TID). Approach to combination therapy: They generally favor add-on rather than immediate combination to reduce confusion about side effects—while acknowledging it may slow reaching “maximal therapy.” Dosing guidance emphasized: Start 18 mg BID for IPF, especially if combined with pirfenidone (since dose reduction may make it ineffective). 9 mg BID may be considered if dose reduction is needed and the patient is not on pirfenidone (e.g., monotherapy or with nintedanib).

Dr. Kahn kicks off 2026 by reviewing recent media reports on aspirin use and dosing for the prevention of cardiovascular events in the President of the United States. Much of the coverage overlooks an important factor: the relationship between aspirin dose and body weight. Dr. Kahn examines data from multiple studies suggesting that, in some cases, only higher-dose aspirin was effective in preventing cardiovascular events. As always, listeners are encouraged to discuss aspirin use and dosing with their own medical team. Additional topics this week include the health impact of carryout meals, kidney function and cystatin C, statin use in patients with diabetes, the risks associated with tramadol, cold drink–induced atrial fibrillation, and recent health reports involving Chevy Chase and Jelly Roll. Dr. Kahn also invites listeners to join an upcoming group 5-day PROLON Fasting Mimicking Diet, supported by dietitians and health educators. Order your PROLON kit now at prolonlife.com/drkahn to be ready to participate.

In this episode of More Than A Pretty Face, Dr. Azi speaks with two leading dermatology experts about modern aesthetic and hair restoration treatments. First, Beverly Hills cosmetic dermatologist Dr. Ardalan Minokadeh shares how neuromodulators, fillers, and facial contouring should be approached differently in men. Then, New York–based dermatologist Dr. Marc Avram breaks down evidence-based hair loss treatments, from medications and PRP to at-home and in-office laser therapies. The episode wraps with practical insights on confidence, aging, and personalized care. Timeline of what was discussed: 00:00 – Intro 00:18 – Submit questions 00:34 – Meet Dr. Ardalan 01:05 – Conference context 01:40 – Men & aesthetics 02:25 – Botox dosing in men 03:10 – Brow positioning 03:45 – Crow's feet focus 04:20 – Dosing approach 05:05 – Icing & comfort 06:05 – Lip filler in men 07:15 – Neck & lower face 08:10 – Trap tox 08:55 – Jawline trends 09:35 – Chin projection 10:25 – Rapid-fire Q&A 11:55 – Where to find Dr. Ardalan 12:30 – Transition 12:51 – Meet Dr. Avram 13:05 – Hair restoration overview 13:35 – PP405 discussion 14:25 – Diagnosing hair loss 15:05 – Medical therapy 15:50 – PRP & regeneration 16:35 – Treatment timelines 17:20 – Combination therapy 18:00 – At-home laser caps 18:45 – In-office lasers 19:35 – Laser mechanism 20:20 – Emerging treatments 21:05 – Choosing a laser cap 21:45 – Supplements 22:50 – Where to find Dr. Avram 23:14 – End   ______________________________________________________________ Follow Ardalan Minokadeh on Instagram: @doctor.ardalan Dr. Ardalan Minokadeh is a board-certified, cosmetic fellowship–trained dermatologist based in Beverly Hills. He specializes in advanced injectable treatments, aesthetic dermatology, and facial balancing for both men and women. Known for his precise, anatomy-driven approach, Dr. Minokadeh is an expert in neuromodulators and dermal fillers, with a strong focus on natural, tailored results and patient-centered care.   Follow Marc Avram on Instagram: @drmarcavram Dr. Marc Avram is a board-certified dermatologist and internationally recognized leader in hair restoration and cosmetic dermatology, based on New York City's Upper East Side. He is the author of multiple textbooks and peer-reviewed publications and is widely regarded for his expertise in medical, regenerative, and laser-based hair loss treatments. Dr. Avram is known for his evidence-based approach, clinical innovation, and dedication to personalized patient care. ______________________________________________________________ Submit your questions for the podcast to Dr. Azi on Instagram @morethanaprettyfacepodcast, @skinbydrazi, on YouTube, and TikTok @skinbydrazi. Email morethanaprettyfacepodcast@gmail.com. Shop skincare at https://azimdskincare.com and learn more about the practice at https://www.lajollalaserderm.com/ The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice. © Azadeh Shirazi, MD FAAD.

Ketamine is a dissociative anesthetic that provides powerful analgesia while preserving spontaneous ventilation, airway reflexes, and sympathetic tone, which makes it especially valuable in trauma, bronchospasm, difficult airways, and in patients with high opioid tolerance. As a phencyclidine derivative with a chiral center, it exists as two enantiomers, with S-ketamine roughly twice as potent as R-ketamine and associated with fewer unpleasant emergence reactions, while its pKa and balanced water–lipid solubility allow rapid CNS penetration and redistribution-limited offset. Its multimodal mechanism centers on noncompetitive NMDA antagonism but also includes opioid receptor modulation, catecholamine reuptake inhibition, AMPA receptor effects, ion channel blockade, muscarinic antagonism, and anti-inflammatory actions, all of which underpin clinical dosing strategies for induction, maintenance, procedural sedation, and analgesic infusions as well as key considerations around emergence delirium, secretions, cardiovascular status, and ICP.Want to learn more? Grab our Cardiac Pharm Course --> [HERE]⚛️ CONNECT:

Join My Private Group: ⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠Q&A on Peptides, Supplements, and Healing ProtocolsIn this episode, Hunter Williams addresses a variety of audience questions on peptides, amino acids, supplements, and health-related protocols. Hunter talks about the best dosages for peptides like 5-amino, Melanotan, and BPC-157, as well as their applications for muscle gain, fat loss, and healing from injuries. He delves into peptide protocols for conditions such as multiple sclerosis, chronic pain, and seasonal allergies. Hunter offers insights into using essential amino acids and testosterone, discusses the effects of GLP-1s, and touches on flying with peptides, bioavailability, and potential side effects. This episode serves as a comprehensive guide to optimizing health and performance, especially through the lens of peptide and supplement use.00:00 Introduction and Q&A Overview02:25 Dosing for 5-Amino and Injection Tips04:02 Flying with Peptides05:01 Essential Amino Acids and Their Benefits05:57 Peptide Protocols for Multiple Sclerosis06:28 B7-33 Peptide Insights07:24 Testosterone Dosing Before a Date08:30 Peptide Purity and TFA Concerns09:19 P21 Peptide for Brain Health10:06 Metformin and SGLT2 Inhibitors11:04 Injection Site Issues and Solutions12:17 VIP Peptide for Erectile Dysfunction13:28 Stacks for Appetite Control and Muscle Gain18:42 HPA Axis and Testosterone Support22:19 Addressing Erectile Function and Blood Pressure22:27 Peptide Stack for Seasonal Allergies22:50 Metformin and Blood Sugar Levels23:40 Growth Hormone Peptides and Pre-Workout Tips24:52 Cloudy Peptides: Causes and Solutions26:11 Alcohol and Peptide Interaction27:47 Melanotan and Vacation Tanning Tips28:41 Peptides for Bulging Discs and Pain Management29:38 Timing for Growth Hormone Peptides30:04 Peptide Recommendations for Energy, Weight Loss, and Muscle Gain30:41 Peptide Use in Older Adults31:20 Combining Peptides for Appetite Suppression32:05 Creatine Benefits for Women in Their Twenties32:11 Comparing Peptides for Longevity and Fat Burning33:12 Chronic Pain Management with Peptides33:41 Addressing Fatigue with Peptides34:33 Switching Peptides for Better Results35:17 Peptides and Skin Tone35:51 Exploring New Peptides for Acne36:26 NAD+ and Peptide Stacks37:01 Hypothyroidism and Testosterone Replacement Therapy37:22 Modafinil for Focus and Neurogenesis38:00 Peptides for Eye Floaters38:14 Prostate Health and Peptides38:36 Critiquing Personal Regimens38:56 Peptides and Tumor Growth39:36 Comparing HGH and HGH Fragments40:21 Testosterone Dosing for Men41:37 Peptides for Post-Surgery Recovery41:58 Final Thoughts and Audience Appreciation

Charley Wininger returns to Adventures Through The Mind to discuss How To Host An MDMA Group Roll Our discussions starts with a quick general overview of MDMA before shifting into a thorough exploration of group rolls—what they are, what they can offer us individually and collectively, who to invite, who not to invite, where to do it, what to include, what to exclude, safety protocols, and just a whole number of things. Enjoy!  

Welcome to the Oncology Brothers podcast! In this episode, we welcomed Dr. Neil Iyengar and Dr. Emily Gallagher, to dive deep into the world of PIK3CA and AKT pathway inhibitors for hormone receptor-positive (HR+) metastatic breast cancer. We discussed the latest approvals, including Inavolisib, Alpelisib, and Capivasertib, and explored their common side effects such as hyperglycemia, rash, and gastrointestinal issues. Our experts shared practical management strategies, dosing considerations, and the importance of patient education to ensure safe and effective treatment. Key topics covered in this episode: • Overview of PIK3CA and AKT inhibitors • Common side effects and their management • The significance of proactive patient education • Dosing strategies and when to consider dose modifications • Insights on managing hyperglycemia and gastrointestinal symptoms This episode is packed with valuable information to enhance your understanding of these important therapies in the breast cancer world. Don't forget to subscribe for more episodes on treatment algorithms, toxicities, and the latest in oncology! #PI3Kinhibitors #BreastCancer #Hyperglycemia #ToxCheck #MetastaticBC #OncologyBrothers #TargetedTherapy

We're taking a break from our regularly scheduled programming for the holidays to bring you something a bit different: a foundational episode that covers everything you need to know about ketamine therapy in one comprehensive resource.Sam originally delivered this presentation to the UCLA and Betty Ford Addiction Medicine Fellowship, and it's become one of those episodes that medical professionals, curious physicians, and anyone seriously exploring this field have come back to. It covers ketamine's complete story, from its fascinating medical history to current research and real-world implementation protocols.Whether you're considering ketamine therapy for your own practice, trying to understand this rapidly evolving field, or just want a solid clinical foundation, this is your starting point. We bridge the gap between academic research and practical clinical application, breaking down complex pharmacology and patient selection in a way that's actually accessible.This is part of our "Episodes from the Vault" series, bringing back content that continues to serve as a go-to resource for healthcare providers across specialties. For those who may recall, this was originally released as Episode 31. The presentation format lets us go deep on each topic while keeping everything practically relevant for actual clinical decision-making.This episode is especially valuable if you're evaluating ketamine therapy integration, seeking to understand the evidence base, or looking to enhance your patient education and staff training.What You'll Learn in This Episode・Ketamine's journey from battlefield anesthetic to breakthrough mental health treatment・Evidence-based mechanisms of action and clinical research findings・Practical patient selection criteria, dosing protocols, and safety considerations for clinical practiceEpisode 46 show notes:00:00 - Teaser - Mental health crisis statistics and ketamine's role00:27 - Introduction to Episodes from the Vault series01:19 - Sam's presentation introduction and off-label use disclosure01:52 - Presentation Overview: Three-part structure: mental health/history, mechanisms/studies, patient selection/protocols02:19 - Part 1: Current State of Mental Health - Depression, PTSD, anxiety statistics and the need for ketamine therapy04:07 - The Need for More Treatment Options: Healthcare arsenal expansion with ketamine04:20 - A Brief History of Ketamine: From phencyclidine to FDA approval and Vietnam War battlefield use09:36 - Part 2: How Ketamine Works - NMDA receptor mechanisms and neuroplasticity effects12:11 - Types of Patient Ketamine Experiences: Four levels of non-ordinary states of consciousness14:49 - A Review of Scientific Studies: Yale study through recent research and meta-analyses22:43 - Part 3: Ideal Patient Selection, Dosing & Scheduling: Contraindications, protocols, and safety considerations32:33 - Episode wrap-up with YouTube resources, and moreThanks for listeningSelected Related Links:・For original Youtube version featuring slides during the presentation, go to https://youtu.be/u9XOQ2xnwsg・For references and studies mentioned in this episode, go to www.ketaminestartup.com/podcast/episode-046Follow us onLinkedinKetamine StartUp WebsiteYouTube

In this week's episode of High on Home Grown, we're breaking down another set of big headlines from around the world: Macky kicks things off with a massive research milestone — over 4,000 studies published this year alone, all while Trump continues to weigh his rescheduling decision. A reminder of just how fast the science is moving, even when politics drags its feet. Billy brings big news for patients in the UK, where experts have released the first comprehensive dosing guide for medical oil products. A huge step toward safer, clearer, and more consistent treatment options for people who've been left guessing for far too long. Dr. Margaret covers an international business move as Calgary-based High Tide continues its expansion into Europe, signalling another wave of global industry growth. She also dives into a charming new study showing that CBD can help aggressive dogs calm down — great news for stressed-out pups and their equally stressed-out humans. And John wraps things up with progress in Kentucky, where the state's first medical dispensary is set to open in the next couple of weeks. The governor is already touting the program as a crucial alternative in the fight against opioid addiction, which could have a major impact across the region. Another packed episode full of science, policy shifts, and global updates — plenty to think about and plenty to discuss.

In today's episode, Vanessa reveals the shocking new human research on two of the most powerful and science-backed supplements for women's fat loss, muscle tone, metabolic health, skin rejuvenation, and longevity: creatine and collagen. You'll discover why creatine is no longer just a gym supplement, and how groundbreaking new data shows collagen may actually influence biological age. This episode is packed with cutting-edge insights every woman needs to hear. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode, you'll learn: ✨ The shocking results from new human studies on creatine and collagen ✨ Why creatine is one of the most underrated supplements for women, especially in perimenopause and post-menopause ✨ How creatine enhances fat loss, muscle tone, metabolic rate, cognition, and sleep-deprivation resilience ✨ The simple, evidence-based dose of creatine that works for women — and why Vanessa uses Puori creatine ✨ The brand new 2025 human trial showing collagen's key amino acids reduced biological age by an average of 1.4 years ✨ How collagen improves skin elasticity, hydration, wrinkles, nails, hair, joints, and connective tissue strength ✨ Why stacking creatine + collagen is a powerful strategy for fat loss, lean muscle retention, skin health, and healthy aging If you want a clear, science-backed guide to creatine and collagen — including exactly how to dose and use them for optimal results — this episode is for you.

In this episode of the PFC Podcast, Dr. Van Wyk discusses the latest updates in traumatic brain injury (TBI) management, focusing on insights from the CRASH-3 trial, the use of TXA, hypertonic saline, and sodium bicarbonate. He emphasizes the importance of monitoring intracranial pressure and the potential for surgical interventions in austere environments. The conversation also touches on the controversial topic of seizure prophylaxis and end-of-life considerations in TBI care.TakeawaysDr. Van Wyk is a neurologist with extensive experience in TBI management.The CRASH-3 trial provides insights into TXA's effectiveness in TBI patients.Moderate TBI patients may benefit more from TXA than severe cases.Dosing protocols for TXA are still under discussion, with traditional methods being preferred.Hypertonic saline is recommended for TBI management, but higher concentrations may be beneficial.Sodium bicarbonate can be an effective alternative for managing ICP.Prophylactic use of hypertonic saline is debated but may be reasonable in certain cases.Seizure prophylaxis is not universally recommended but can prevent complications in TBI patients.Monitoring ICP through optic nerve sheath diameter is evolving, with trends being more useful than absolute values.Surgical interventions for TBI may be necessary in austere environments, but should be approached with caution.Chapters00:00 Introduction to Traumatic Brain Injury Management02:00 Insights from the CRASH-3 Trial06:43 Dosing Protocols for TXA in TBI11:28 Hypertonic Saline: Concentration and Administration17:21 Alternative Treatments for Increased ICP22:58 Prophylactic Sodium Management in TBI25:17 Seizure Prophylaxis in Traumatic Brain Injury30:04 Monitoring Intracranial Pressure Non-Invasively35:17 Surgical Interventions for Elevated ICP42:10 End-of-Life Decisions in Severe TBIFor more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠

Very Low Nicotine Content Cigarettes for Smoking Cessation: Examining a Facilitated Extinction Approach and Dosing Schedule Drug and Alcohol Dependence Very low nicotine cigarettes (VLNC, 0.4 mg nicotine/g tobacco) have been shown to reduce smoking behavior when compared to normal nicotine cigarettes (NNC,17 mg nicotine/g tobacco). Participants (n=208) were randomly assigned to 4 experimental groups, immediate versus gradual (over 5 weeks) transition to VLNC, and standard counseling versus facilitated extinction counseling (weekly for 5 weeks). Facilitated extinction had participants smoke only in relevant contexts (e.g., places, affects, triggers). The immediate nicotine reduction group reported less smoking satisfaction and lower completion rates (72% immediate reduction versus 88% gradual reduction, p=.02). Abstinence (biochemically verified) at 2 months post study was 29%. There were no significant differences between the 4 study groups. VLNC were beneficial in smoking cessation.   Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM

Discover the latest science behind fasting and innovative fasting alternatives in this episode with Dr. Chris Rhodes, nutritional biochemist. Learn about the anti-inflammatory and longevity benefits of a 36-hour fast, and how Mimio, a fasting supplement, can help you access fasting's advantages without skipping meals. With special insights on women's health—including hormones, muscle preservation, and metabolic changes—this is essential listening for anyone interested in optimizing wellness, especially women navigating midlife.Curious to try Mimio for yourself? Visit https://drstephanieestima.com/mimio and use code ESTIMA for 20% off. Episode Overview (timestamps are approximate):(0:00) Intro/Teaser(4:00) The Biology of Fasting: What's Actually Happening(12:00) Fasting Timelines: 16:8 vs 24hr vs 36hr(16:00) The 36-Hour Metabolic Signature(21:00) NAD, Estrogen, and Women in Midlife(26:00) Cortisol, HPA Axis, and Female Sensitivity(30:00) Thyroid Suppression During Fasting(34:00) Muscle and Bone Preservation Strategies(43:00) The Four Fasting-Mimetic Molecules(54:00) Fasting Benefits Without Fasting(1:03:00) Clinical Study Results: 2.5 Years Younger(1:07:00) Dosing and Best Practices(1:12:00) BONUS: After-Party with Dr. StephanieResources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep445/We couldn't do it without our sponsors:BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER.TROSCRIPTIONS - There's a completely new way to optimize your health. Give it a try at https://troscriptions.com/BETTER or enter BETTER at checkout for 10% off your first order.BIOPTIMIZERS - Your digestion can take a hit in midlife, but you don't have to suffer. Learn how enzymes can help at https://bioptimizers.com/better and use code BETTER to get 10% off your order.MASA - MASA's chips contain just three ingredients: organic nixtamalized corn, sea salt, and 100% grass-fed beef tallow. That's it. Ready to give MASA (or Vandy) a try? Use code BETTER for 25% off your first order at https://masachips.com/BETTERLMNT - Rehydrate with the perfect mix of sodium, potassium, and magnesium. Get a free sample pack at https://drinklmnt.com/drestima. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Presbyopia is finally meeting its match in-clinic with Qlosi™ presbyopia eye drops (pilocarpine 0.4%), offering a practical, performance-based option alongside glasses, contact lenses, and surgery. In this episode, Dr. Jennifer Lyerly and Dr. Derek Cunningham discuss how to position presbyopia drops for success, including who to treat, how to dose, what to say chairside, and why athletes appreciate the functional freedom.

In this episode, Linda Nurra returns to discuss the practical role of flower essences and how they complement homeopathy. She explains why flower essences are accessible tools for both practitioners and home prescribers, especially when supporting emotional well-being. Linda highlights how these remedies can help homeopathy students manage common challenges such as overwhelm, insecurity, and perfectionism. She also describes how flower essences can support clients during homeopathic aggravations without interfering with remedies. Throughout the conversation, Linda emphasizes self-care, emotional intelligence, and the importance of empowering individuals with gentle, supportive tools. Episode Highlights: 05:35 - Flower essences and homeopathy as sister healing arts 07:29 - A bridge for people not yet ready for homeopathy 09:58 - Whole-person focus over diagnoses 13:30 - Flower essences extending support beyond acute care 18:12 - Ideal gift for pregnant friends or midwives 21:35 - Supportive remedies for each stage of learning 24:31 - Flower Essences for Guilt and Boundaries 27:30 - Remedy that can help students return to the present moment 30:27 - Dosing and Application of Flower Essences 40:14 - How Flower Essences Encourage Self-Reflection in Children 46:46 - Managing Remedy Aggravations with Flower Essences 47:56 - Using Rock Rose for Panic and Anxiety 50:14 - When Theory Meets Reality About my Guests: Linda Nurra, PhD, CCH, RSHom(NA), is a dedicated teacher whose work bridges homeopathy, flower essence therapy, and the deeper study of human meaning and consciousness. With a background in humanities, linguistics, and semiotics, she spent years in higher education as an instructor, curriculum designer, trainer, and leader. Her healing path began nearly three decades ago with an encounter with flower essences—a moment that opened the door to exploring human emotion, the wisdom of plants, and the transformative capacity of nature. That journey eventually expanded into studies of spiritual and healing traditions, culminating in a profound experience with a homeopathic remedy that set her on a new professional course. Linda earned her advanced practitioner diploma from the School of Homeopathy (UK) and has since trained with leading teachers around the world. Her career has focused on teaching, writing, community-building, and supporting both students and practitioners in deepening their understanding of holistic healing. She has served as curriculum director and lead faculty at the Prometheus Homeopathic Institute, taught for the Los Angeles School of Homeopathy and the Veterinary Homeopathy Institute, and contributed to multiple publications. A former board member of the California Homeopathic Medical Society, Linda also leads several study groups that foster collaboration, learning, and a vibrant sense of community within the homeopathic field. Find out more about Linda Website: https://www.insighthomeopathy.com/ Instagram: https://www.instagram.com/linda_nurra/ Facebook: https://www.facebook.com/BachforHomeopaths YouTube: https://www.youtube.com/@lindanurra/shorts If you would like to support the Homeopathy Hangout Podcast, please consider making a donation by visiting www.EugenieKruger.com and click the DONATE button at the top of the site. Every donation about $10 will receive a shout-out on a future episode. Join my Homeopathy Hangout Podcast Facebook community here: https://www.facebook.com/groups/HelloHomies Follow me on Instagram https://www.instagram.com/eugeniekrugerhomeopathy/ Here is the link to my free 30-minute Homeopathy@Home online course: https://www.youtube.com/watch?v=vqBUpxO4pZQ&t=438s Upon completion of the course - and if you live in Australia - you can join my Facebook group for free acute advice (you'll need to answer a couple of questions about the course upon request to join): www.facebook.com/groups/eughom  

Today, I am delighted to be joined by a friend and colleague, Mike Mutzel.  Mike has a master's in Clinical Nutrition from the University of Bridgeport. He is a graduate of the IFM, applies functional medicine in clinical practice, and is a consultant lecturer who teaches leading-edge science in a concise format for progressive clinicians to prevent chronic diseases.  In our discussion, Mike and I unpack the benefits of creatine monohydrate, highlighting the importance of ensuring the products we use are free of impurities. We explain how creatine monohydrate gets created, answer many listener questions, and describe current research specific to creatine monohydrate, discussing ways to support bone health, navigate dosing, and how to troubleshoot.  This conversation with Mike Mutzel is truly invaluable, and I look forward to having him back on the podcast to dive a little deeper into the science.  IN THIS EPISODE, YOU WILL LEARN: How creatine supports energy production across muscles, the brain, and other organ systems Why vegetarians and vegans should take creatine What to consider when choosing high-quality creatine supplements Dosing strategies based on diet, exercise, sleep, and individual needs How taking creatine with electrolytes while exercising can improve absorption Benefits of supplementing with amino acids alongside creatine for illness, recovery, or when protein intake is low Adjusting your creatine dosage for sleep, travel, or exercise demands How creatine supports bone and muscle health  The value of creatine for the eyes and ears Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Mike Mutzel On his website YouTube Instagram High Intensity Health Podcast Creatine Research: Creatine in Women's Health: Bridging the Gap From Menstruation Through Pregnancy to Menopause Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial

Another powerful episode is live here on IVPN-Voice!

I'm joined today by Edmarie Guzman-Velez & Rudy Tanzi as we dig into a clinical trial of nicotinamide riboside for Long Covid, why NAD matters for cellular energy, and where the results show promise for fatigue, sleep, mood, and executive function. We share what worked, what did not, and the next steps.• Overview of NAD, mitochondria, and energy in brain and immune cells• Why Covid may deplete NAD and how NR restores it• Trial design using intra-individual crossover with placebo run-in• Dosing at 2,000 mg NR daily under IRB oversight• Serial NAD blood measurements confirming a threefold rise• Outcomes on fatigue, sleep quality, depressive symptoms, executive function• Limits of small samples and reinfection attrition• Safety, label guidance, and medical supervision for supplements• Plans for biomarkers of inflammation and activity data from wearables• Future research on symptom clusters, sex differences, and combinationsLinks:Full paper available HEREMore about Niagen Bioscience Dr. Tanzi is paid consultant for, and equity holder in Niagen Biosciences.Message the podcast! - questions will be answered on my youtube channel :) For more information about Long Covid Breathing courses & workshops, please check out LongCovidBreathing.com (music credit - Brock Hewitt, Rule of Life) Support the show~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~The Long Covid Podcast is self-produced & self funded. If you enjoy what you hear and are able to, please Buy me a coffee or purchase a mug to help cover costsTranscripts available on individual episodes herewww.LongCovidPodcast.comFacebook Instagram Twitter Facebook Creativity GroupSubscribe to mailing listI love to hear from you, via socials or LongCovidPodcast@gmail.com**Disclaimer - you should not rely on any medical information contained in this Podcast and related materials in making medical, health-related or other decisions. Please consult a doctor or other health professional**

Donate (no account necessary) | Subscribe (account required) Join Bryan Dean Wright, former CIA Operations Officer, as he dives into today's top stories shaping America and the world. In this Monday Headline Brief of The Wright Report, Bryan examines the rising risk of war with Venezuela, secret peace talks over Ukraine, the abduction of Christian schoolchildren in Nigeria, Israel's shifting posture in Gaza and Lebanon, and the domestic political fight over sedition and extremist rhetoric inside the United States government. U.S. and Venezuela Move Closer to War: President Trump authorized covert CIA operations inside Venezuela, prompting the FAA to warn airlines about dangerous conditions in Venezuelan airspace. Reports from Bloomberg, Reuters, and the New York Times confirm GPS jamming and rising military activity. A Russian oil tanker headed for Caracas was turned away twice by the USS Stockdale and is now anchored off Cuba. Bryan notes that the White House still hopes for a peaceful exit by President Maduro, with Colombia offering asylum in exchange for guarantees of no future attempts to kill or arrest him. Trump's Ukraine Peace Plan Faces Pushback: A secret twenty-eight-point peace plan leaked last week, calling for Ukraine to give up parts of the Donbas, reduce its military to six hundred thousand troops, and abandon NATO membership. The plan would also restore economic ties between Russia and the West and release frozen Russian funds for joint rare earth projects. European leaders object, and President Zelenskyy says negotiations must continue, insisting Ukraine needs a larger standing army to deter future invasions. Bryan emphasizes that Trump wants the deal signed by Thanksgiving, warning Zelenskyy that U.S. support may end if he refuses. Ukraine's Deepening Corruption Crisis: Fifteen to thirty percent of aid intended for Ukraine's military and energy needs has been stolen, according to recent reporting. Several allies of Zelenskyy have been arrested, and the president's key aide, Andriy Yermak, is widely suspected of involvement. Ukraine's anti-corruption agency plans more indictments this week, placing Zelenskyy in a weakened negotiating position. Islamists Kidnap Christian Children in Nigeria: Three hundred Christian students were abducted from a Catholic school in central Nigeria. About fifty escaped by fleeing into the forest and hiding until farmers rescued them. Boko Haram and other jihadist factions are believed to be responsible. Bryan warns that these groups aim to build an Islamic caliphate across the Sahel and into the Gulf of Guinea, threatening regional Christians and strategic minerals such as cocoa, iron ore, bauxite, and oil. Trump has warned Nigeria that failure to protect Christians could trigger U.S. military action. Israel Reshapes Gaza and Expands Strikes in Lebanon: U.S. troops are withdrawing from Gaza's coordination center. Israeli, Arab, and vetted Palestinian officials will manage reconstruction in a new "Green Zone," while unvetted Palestinians remain in a devastated area controlled by Hamas. Polling shows Hamas' support has risen inside Gaza, meaning roughly half the population may remain under militant control. Israel also intensified operations in Lebanon, killing Hezbollah's top military commander in a drone strike despite an ongoing ceasefire. Jewish Extremists Spark Crisis in the West Bank: Prime Minister Netanyahu convened emergency meetings after Jewish extremists torched Palestinian homes and cars in a village attack. Israeli officials say about two hundred seventy young men are responsible for the most recent incidents and vow to act. Sedition Caucus Escalates Rhetoric Against Trump: Former CIA, FBI, and military officials who now serve as Democrats in Congress released a video urging service members to resist unlawful orders from President Trump. Senator Elissa Slotkin admitted she knows of no unlawful orders but says such orders might come. Bryan calls the effort a psychological operation designed to sow confusion inside the military. Legal experts warn that service members who refuse lawful orders could face court-martial and prison. Trump Meets NYC's Socialist Mayor Elect: Zohran Mamdani met with President Trump on Friday, and the two agreed on issues such as electricity costs and housing. Mamdani later repeated his belief that Trump is a fascist and a Nazi, prompting Republican leaders like Elise Stefanik to call Mamdani a jihadist with a long documented history of radical associations. Bryan argues the evidence strongly supports Stefanik's view and warns against normalizing Mamdani's ideology. Eric Swalwell Runs for Governor of California: Representative Swalwell announced his campaign on Jimmy Kimmel Live, promising to lead the "Resistance" against Trump. Bryan revisits the long-running Chinese influence operation that targeted young California Democrats, including Swalwell, and raises questions about whether the FBI ever thoroughly investigated the network linked to his former associate Fang Fang. Good News in Medicine: Japanese researchers found that the amino acid arginine significantly reduced Alzheimer's-related plaque and inflammation in animal studies. Dosing remains experimental, but Bryan notes it could offer a promising option for families exploring right-to-try pathways.   "And you shall know the truth, and the truth shall make you free." - John 8:32   Put a smile on your face and give joy to your taste buds… Give Masa and Vandy beef tallow chips a try today! Use code WRIGHT for 25% off your first order… at MASAchips.com or VandyCrisps.com. So incredibly delicious! I promise, you won't be disappointed.   Keywords: Venezuela CIA operations FAA warning, USS Stockdale Russian tanker, Maduro Colombia asylum offer, Ukraine Trump twenty eight point plan, Donbas concessions NATO ban, Zelenskyy corruption Yermak indictments, Nigeria Christian school kidnapping Boko Haram, Gaza Green Zone Hamas polling, Hezbollah commander killed Lebanon, Slotkin sedition unlawful orders video, Zohran Mamdani socialist jihadist ties, Eric Swalwell Fang Fang China influence, arginine Alzheimer's study Japan

Get a practical breakdown of Afrezza, the ultra-rapid inhaled insulin, with this comprehensive guide to efficacy, timing, and real-world application. Join Drs. Jeremy Pettus and Steve Edelman—endocrinologists living with Type 1 diabetes—as they reveal why this unique tool is often misunderstood and how to use it effectively to flatten post-meal spikes.In this episode, we move beyond the basics to correct the biggest mistake users make regarding Afrezza dosage. If you've tried this therapy before and felt it "didn't work," the issue often lies in the conversion ratio. We review data from Afrezza MannKind studies (such as INHALE-3) to explain the shift from the old 1:1 ratio to the more effective 1:3 ratio. We also cover why this "rapid-on, rapid-off" insulin is the ultimate solution for exercise and how to navigate insurance coverage and prior authorizations.Topics covered in this episode:The Dosing Fix: Why you often need a higher Afrezza dosage compared to subcutaneous insulin.Speed & Kinetics: How inhaled insulin mimics the body's natural beta cells to clear glucose fast.Lifestyle Benefits: Managing "sticky highs," exercise without crashing, and dietary freedom.Safety & Screening: Spirometry requirements and who should (and shouldn't) use Afrezza.Pediatric Updates: The latest on clinical trials and potential approval for children.Whether you are managing Type 1 or Type 2 diabetes, this episode provides the practical "tips and tricks" you need to determine if Afrezza is the missing tool in your diabetes management kitTimecodes: 0:00 Intro: Inhaled Insulin History 0:59 How Fast is Afrezza? (Rapid On/Rapid Off) 2:19 Why It Prevents "Delayed Lows" 3:24 The Big Mistake: Why Dr. Pettis Quit Using It 5:20 The Correct Dosing Conversion (1:1 vs 1:3) 7:40 Timing: Do You Need to Pre-Bolus? 8:44 "Follow-On" Dosing for High Protein/Fat Meals 10:32 Cartridge Sizes & "Bucket" Dosing 12:11 Using Inhaled Insulin for Exercise 13:58 Real-World Test: Trix Cereal & Afrezza 15:00 Storage Tips: Fridge vs. Room Temp 16:20 Dealing with the Cough Side Effect 17:05 Proper Inhalation Technique 19:13 Using Afrezza with Insulin Pumps & Closed Loops 21:30 Pediatric Update: Is it Safe for Kids? 23:25 Lung Safety, Smokers & Spirometry Tests 24:25 How to Talk to Your Doctor About Afrezza 26:32 Prescriptions & Trainers 28:44 ConclusionVisit TCOYD's Website for more diabetes edutainment for people living with diabetes: tcoyd.org**Tune in for two new episodes each month! Like what you hear and want to help us grow? Please rate and review this podcast so we can reach more people living with diabetes!**Follow our social media channels to empower yourself with the essential areas of diabetes knowledge led by two endocrinologists living with type 1 diabetes: Facebook  |  Instagram  |  YouTube ★ Support this podcast ★

In this months Q&A episode I answer listener questions including: What are my thoughts on B vitamins? Should we supplement them or get them from food? What is one thing the anti PUFA crowd gets wrong? What are my thoughts on testing omega 3:6 ratio from a dried blood spot sample? What do I think about Dr Matthew Walker on Diary of a CEO Podcast saying "don't supplement large doses of melatonin"? What is a good dose of melatonin for kids? Have I ever taken melatonin to lower anxiety? What do I think about red light and PEMF mats? What is my parasite strategy? What belief or mindset shift created the biggest change in my health? I share why I think vitamin B3 as niacinamide/nicotinamide is one of the most important ones to take, how B3 protects against several different types of cancers, why cigars don't protect from pathogens in oysters, the immense stress lowering effect I felt when I stopped demonizing ascorbic acid, zinc, iron, and vitamin D supplements, and why I think the should observe the diets of deer and elk with the PUFA conversation instead of getting lost in analyzing endless research studies.  My website: www.matt-blackburn.com Mitolife products: www.mitolife.co BLACK FRIDAY SALE STARTS MONDAY 11/24 Some of the studies cited in the show:  NIacinamide skin cancer study https://pmc.ncbi.nlm.nih.gov/articles/PMC4570055/ Niacinamide non hodgkin lymphoma study https://pubmed.ncbi.nlm.nih.gov/37467318/ PUFAs as Anti-Freeze article: https://www.anbg.gov.au/cryptogams/underworld/panel-13/index.html Music by George Henner: https://georgehenner.bandcamp.com

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption. Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork. You'll Learn: • Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood • The exact signs that your dose is too strong, too weak, or in the Goldilocks zone • How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience • Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions • How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters • The link between mitochondrial health, fertility, libido, and long term anti aging strategies • How to track sleep optimization, HRV, and performance signals to dial in your personal protocol • The difference between aquarium grade dye and pharmaceutical grade formulations • Why genetic testing for G6PD deficiency is essential before higher dose experimentation Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair Thank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 4:51 — History of methylene blue 7:38 — How methylene blue works 14:05 — Safety 17:53 — Dosing and timing guidelines 20:41 — Combining with red light therapy 22:41 — Quality and sourcing 23:17 — Dosing protocols 25:24 — Longevity and fertility effects 29:24 — Stacking options 32:10 — Common questions and FAQs 33:40 — Future research and wrap up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Glycopyrrolate is an anticholinergic medication commonly used to reduce excessive secretions, particularly in palliative care, postoperative settings, and certain neurologic conditions. It works by blocking acetylcholine at muscarinic receptors, which decreases salivary and respiratory secretions. Clinically, glycopyrrolate is often used to manage terminal respiratory secretions (“death rattle”). Adverse effects of glycopyrrolate are primarily related to its anticholinergic properties. These may include dry mouth, constipation, urinary retention, blurred vision, tachycardia, and decreased sweating. While it has fewer central effects than agents like scopolamine, caution is still warranted in patients with glaucoma, gastrointestinal obstruction, or significant urinary retention risk. Monitoring hydration and bowel function is important, especially in elderly or frail patients. Dosing strategies depend on the clinical need. In palliative care, low doses may be given subcutaneously or intravenously every 4–6 hours as needed, while oral dosing is common for chronic sialorrhea. Clinicians should consider the patient's overall medication burden, as cumulative anticholinergic load can worsen cognitive impairment and contribute to falls or constipation. I discuss drug interactions and other commonly used medications that may contribute to anticholinergic burden.

Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIn this compilation episode, Dr. Gabrielle Lyon is joined by the top experts in Testosterone and men's health treatments. You'll learn:Why aging alone doesn't drop T levels and why acquisition of conditions like obesity is the real culprit.Why the standard "low T" cutoff is misleading and why you must check your Free Testosterone.How erectile dysfunction is a sensitive marker of overall health and heart risk.The efficacy of Cialis/Viagra for both erections and cardiac protection, and the risks of unchecked influencer advice on steroids.The direct link between muscle mass, exercise, and sexual function—and why the penis is the "first to go" when overall health declines.Chapter Markers:0:00 - Testosterone is a Brain Hormone0:40 - Debunking the Myth: Male Menopause (Andropause) Doesn't Exist1:33 - The Dangers of Unchecked Influencer Advice on Testosterone3:07 - Defining Testosterone Deficiency: Symptoms vs. Signs5:10 - The Arbitrary Number: Why Guidelines Disagree on Low T8:29 - Free Testosterone: The Most Reliable Indicator of Male Health15:28 - TRT vs. Steroids: Defining the Line and Risks18:59 - The Real Risks of TRT: Infertility and Hematocrit22:36 - The Shocking Backstory: Challenging the Prostate Cancer Myth26:40 - Erectile Dysfunction (ED) and Lifestyle Modification29:21 - Shockwave Therapy for ED: The Science and the Cash Business33:53 - Penile Tissue Atrophy and Venous Leak37:25 - The Role of Muscle Mass, Sarcopenia, and Sexual Function39:41 - The Single Best Marker for Male Health: Erectile Function42:02 - The Science of Cialis and Viagra (PDE5 Inhibitors)45:49 - The Viagra Story: From Heart Drug to ED Cure50:50 - Tadalafil (Cialis) as a Triple-Threat Drug (Cardiac, Urinary, Sexual)53:57 - The Role of Testosterone in Female Sexual Function55:20 - Hypogonadism: Diagnosis, Treatment, and Fertility RiskAbout the guests: Dr. Abraham Morgentaler is an Associate Clinical Professor of Urology at Harvard Medical School and founder of Men's Health Boston. He is an internationally recognized expert in men's health, particularly known for his pioneering work in testosterone therapy. Dr. Morgentaler is credited with reversing the long-held belief that testosterone therapy causes prostate cancer and is the author of several books on men's health. YouTubeLinkedInT4L EducationX/Twitter Dr. Tobias Kohler is the co-founder of the Erectile Restoration Outcomes Study (EROS) penile implant registry. In addition to his clinical and research activities, Dr. Kohler is active in education, providing mentorship to residents and fellows.Mayo Clinic ResearchGateLinkedIn

Join Dr Sofia Ramiro and Professor Xenofon Baraliakos as they discuss the top publications in the world of axSpA. This month, the conversation covered the Association between adalimumab dosing interval and uveitis recurrence in patients with ankylosing spondylitis.

In this conversation, Dr. Nathan Bryan discusses the critical role of nitric oxide in human health, its production, and the factors that can lead to its deficiency. He explains how nitric oxide functions as a signaling molecule, its importance in cardiovascular health, athletic performance, and immune function, and the misconceptions surrounding nitric oxide supplements. The discussion also covers the impact of diet, oral hygiene, and lifestyle choices on nitric oxide levels, as well as practical biohacks to enhance its production. Dr. Bryan emphasizes the need for restorative physiology in health management and the potential of nitric oxide in future medical therapies.Dr. Nathan S. Bryan is a revolutionary scientist, biotech entrepreneur, and industry disruptor who is redefining the way we think about health, longevity, and human performance. With over 100 peer-reviewed publications and dozens of patents, his groundbreaking discoveries in nitric oxide research have shattered conventional health myths, igniting a billion-dollar market and transforming countless lives. A former professor of molecular medicine, Dr. Bryan left academia to take on Big Pharma and misinformation head-on, delivering real, science-backed solutions directly to the public. Now, as a sought-after speaker and author of The Secret of Nitric Oxide: Bringing the Science to Life, he's on a relentless mission to arm people with the tools to reclaim their health, optimize performance, and defy aging.SHOW NOTES:0:39 Welcome to the podcast!1:48 Dr. Nathan Bryan's Bio2:29 Welcome him to the show!3:30 The purpose of Nitric Oxide in the human body5:11 What depletes our Nitric Oxide?8:27 Erectile dysfunction & Viagra13:12 Can NO override bad habits?14:41 Nitrate-rich foods17:06 Oral microbiome & blood pressure19:29 How nitric oxide affects sleep apnea & sleep-disordered breathing 21:52 Breathing while exercising23:41 Supporting the immune system with NO25:42 Testing levels with saliva strips28:36 Dosing nitric oxide31:08 Arginine & Citrulline supplements37:36 Pharmaceutical industry45:25 Heavy metals & adrenal tumors48:39 Dr. Nathan's morning routine53:19 Where to find him54:32 Thanks for tuning in!RESOURCES:Website: drnathansbryan.comN1O1 SupplementsIG: @drnathansbryanYouTubeSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

The JournalFeed podcast for the week of Nov 3-7, 2025.These are summaries from just 2 of the 5 articles we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Wednesday's Spoon Feed:The Safeback SBX device can improve survival in an avalanche, but does not replace the need for appropriate education and knowledge regarding avalanche safety.Friday's Spoon Feed:For anaphylaxis in adults ≥50kg, 0.5mg vs. 0.3mg IM epinephrine is strongly associated with a reduction in escalation of care (repeat epi, epi drip, or intubation).

Testosterone therapy can improve libido in postmenopausal women.Sexual dysfunction in women is complex and multifactorial.Low sexual desire is only considered a disorder if it causes distress.Psychosocial factors play a significant role in sexual health.Testosterone levels do not change significantly at menopause.The placebo effect can significantly influence treatment outcomes.Individualized care is crucial in managing sexual dysfunction.Dosing for testosterone therapy should be carefully monitored.Current medications for low libido have modest benefits.Evidence for testosterone therapy in premenopausal women is still emerging.Tap to Follow Dr.Susan Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Dr. Abbie Smith-Ryan, a leading researcher in exercise science and women's health, breaks down the science behind creatine and its many benefits for women. From reducing inflammation and improving recovery to boosting brain health, mood, and sleep, Dr. Smith-Ryan shares the latest research and practical advice on how women can safely and effectively use creatine. She also addresses common myths and side effects, the best dosing strategies, and how creatine can support everything from menstrual health to perimenopause.→ Leave Us A Voice Message! Topics Discussed: → What are the benefits of creatine for women?→ Does creatine help with perimenopause and hormones?→ How does creatine support brain health and mood?→ Can women build muscle and bone mass with creatine?→ Is creatine safe for postpartum recovery?Sponsored By: → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com.→ AG1 | Head to https://drinkag1.com/bewell to get a FREE Welcome Kit with the flavor of your choice that includes a 30 day supply of AGZ and a FREE frother. → Function | Learn more and join using my link. Function is the new essential health check, and my first 1000 listeners get a $100 credit toward their membership. Visit https://www.functionhealth.com/bewellbykelly or use gift code BEWELL100 at sign up to own your health.→ Vuori | Get 20% off your first order of Vuori AND free shipping on orders over $75 at https://vuori.com/kellyTimestamps: → 00:00:00 - Introduction→ 00:02:48 - Creatine for inflammation & recovery→ 00:07:05 - Other uses of creatine→ 00:12:59 - Creatine & menstruation→ 00:16:46 - PCOS & irregular cycles→ 00:17:44 - Creatine side effects→ 00:20:55 - Dosing & loading phase→ 00:26:13 - Perimenopause study insights → 00:33:11 - Brain health, mood & sleep→ 00:36:09 - Cognition & hormones→ 00:38:27 - When & how to take creatine→ 00:41:10 - Combating the afternoon crash→ 00:44:15 - Body composition explained→ 00:46:21 - Best workout times→ 00:48:49 - Fasted exercise pros & cons→ 00:52:14 - Improving bone & muscle mass→ 00:56:49 - Heavy lifting & proper form→ 00:58:04 - Surgery & injury considerations→ 00:59:07 - Lifelong athletic training→ 01:02:40 - Postpartum recovery tips→ 01:06:11 - Blood sugar balance→ 01:09:10 - Water weight & puffiness→ 01:10:54 - Types of creatineCheck Out Abbie:→ IG: @asmithryan→ WebsiteCheck Out Kelly:→ Instagram→ YouTube→ Facebook

In this week's BeBattleReady podcast, Simon Ward welcomes back Dr Tommy Wood to explore one of the most researched yet misunderstood supplements - creatine. While most athletes associate it with muscle strength, Tommy explains why its benefits go far beyond the gym, extending to brain health, cognitive function, and ageing well. Together, they unpack how creatine works, who should consider supplementing, the differences between athletic and cognitive benefits, and why it might be particularly valuable for older athletes and post-menopausal women.   Key Points Discussed: Creatine as a brain protector: Originally known for supporting strength and power, creatine also acts as an energy buffer for the brain, helping maintain cellular energy after head trauma and possibly reducing cognitive decline. Who benefits most: While everyone can gain from adequate creatine levels, the strongest evidence shows benefits for older adults, athletes at risk of head injury, and women in peri- and post-menopause — particularly for memory and bone health. Dosing, loading, and myths: You don't need the old “loading phase.” Regular small doses (3–5 g daily) are safe and effective. The minor weight gain some notice is simply better muscle hydration, not “bloating.” Sleep, mood, and cognition: Studies show creatine can offset mental fatigue and cognitive decline during sleep deprivation, and even support mood when used alongside standard therapy for depression. Safety and practical takeaways: Creatine monohydrate (especially the Creapure® form) remains the gold standard. It's safe for most people, though those with kidney issues should consult their doctor. Foods like sardines, herring, mackerel, and red meat also provide natural sources.   Key Quotation: “Creatine is probably one of the most studied supplements in the world — and on balance, it's safe, effective, and beneficial for both the body and the brain.” — Dr Tommy Wood   Connect with Dr. Tommy Wood: Website: drtommywood.com Instagram: DrTommyWood Substack: Better Brain Fitness Podcast: Better Brain Fitness Podcast   Dr. Tommy Wood's Book (Pre-order now): The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age (Release: March 24, 2026)   Book Recommendations: Attention Span by Gloria Mark - how to find focus for a fulfilling life. The Comfort Crisis by Michael Easter - embrace discomfort to reclaim your wild, happy, healthy self.     Join the SWAT Inner Circle   The SWAT Inner Circle is now open. It is the community for athletes and adventurers over 50 who want to train smart, live well, and extend their health span.  You can join today CLICK HERE TO START YOUR MISSION   Check out my Instagram  and YouTube  channel   Join the Unstuck Collective – for Beth's weekly inspiration and coaching insights (not a chat group; replies welcome via DM). Download Simon's Free ‘Battle Ready Lifestyle' Infographic — https://simon-ward.kit.com/battlereadylifestyle Website: www.simonward.co.uk Email: Simon@thetriathloncoach.com Sign up for Simon's weekly newsletter Sign up for Beth's weekly newsletter  

Nicotine isn't just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you'll learn how controlled, low-dose nicotine may enhance brain performance, boost neuroplasticity, improve mitochondrial function, and potentially extend lifespan. Host Dave Asprey breaks down the surprising science behind this controversial compound, separating fact from fear—and exposing the real risks that nobody talks about. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll discover how nicotine affects neurotransmitters, why it may help with ADHD and focus, and how it compares to other cognitive enhancers like caffeine, nootropics, and even smart drugs. Dave explores how nicotine can be used to hack metabolism, enhance sleep optimization, and support fasting or ketosis protocols—if used properly. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll Learn: • How nicotine affects mitochondria, neurotransmitters, and dopamine signaling • Why nicotine may boost neuroplasticity, memory, and attention span • How low-dose nicotine compares to caffeine, modafinil, and other nootropics • The safest delivery forms (and the ones to avoid) • Whether nicotine supports or hinders longevity and cognitive resilience • How it can be stacked with supplements, fasting, or ketosis • What functional medicine says about chronic use, addiction, and withdrawal This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Nicotine microdosing, Nicotinic acetylcholine receptors, Dopamine and motivation, Cognitive enhancement, Alzheimer's prevention, Neuroinflammation, Mitochondrial function, TNF-alpha reduction, Vagus nerve activation, Longevity biohacking, Nicotine vs smoking, Nootropics, Attention and vigilance, Ketosis and metabolism, Functional medicine, Nicotine patches and gum, Addiction and tolerance, Receptor desensitization, Withdrawal protocols, Deep work performance Thank you to our sponsors! -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -HeartMath | Go to https://www.heartmath.com/dave to save 15% off. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 1:27 — History & Background of Nicotine 4:34 — How Nicotine Works 15:12 — Benefits & Research 16:43 — Risks & Who Should Avoid It 21:39 — Delivery Methods & Dosing 26:30 — Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Drs. Erin Barreto (@erin_barreto) and Jeffrey Lipman join Dr. Whitney Buckel for a conversation on ideal dosing of cefepime. Hear from the experts on the differences between package insert and “high-dose” regimens, adjustments for renal impairment/augmented renal clearance, and the role of cefepime therapeutic drug monitoring. References: Barreto EF, et al. Setting the Beta-Lactam Therapeutic Range for Critically Ill Patients: Is There a Floor or Even a Ceiling? Crit Care Explor. 2021 Jun 11;3(6):e0446.PMID: https://pubmed.ncbi.nlm.nih.gov/34136822/ Barreto EF, et al. Adequacy of cefepime concentrations in the early phase of critical illness: A case for precision pharmacotherapy. Pharmacotherapy. 2023 Nov;43(11):1112-1120. https://pubmed.ncbi.nlm.nih.gov/36648390/ ** **Udy AA, et al. Augmented renal clearance: implications for antibacterial dosing in the critically ill. Clin Pharmacokinet. 2010;49(1):1-16. https://pubmed.ncbi.nlm.nih.gov/20000886/ Lipman J, Wallis SC, Boots RJ. Cefepime versus cefpirome: the importance of creatinine clearance.   Anesth Analg. 2003 Oct;97(4):1149-1154. doi: 10.1213/01.ANE.0000077077.54084.B0.PMID: 14500173 Roberts JA, Ulldemolins M, Roberts MS, McWhinney B, Ungerer J, Paterson DL, Lipman J. Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept.  Int J Antimicrob Agents. 2010 Oct;36(4):332-9. doi: 10.1016/j.ijantimicag.2010.06.008. Epub 2010 Aug 3.PMID: 20685085

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you'll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools used by elite thinkers, fighter pilots, and world leaders. This is not a sales pitch. It is an educational masterclass on how to upgrade your brain beyond what it can ever do naturally. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey takes you inside the full playbook of Modafinil, a prescription nootropic often called the “real Limitless pill.” With over 20 years of personal experience using it daily alongside biohacking stacks of supplements, fasting, ketosis, cold therapy, sleep optimization, and Danger Coffee, Dave explains why Modafinil is more than just a wakefulness drug. It is a brain optimization tool that supports mitochondrial energy, resilience, and cognitive clarity. Together with decades of research, Dave shows you how Modafinil compares to stimulants like Adderall and caffeine, why it was adopted by Air Force pilots and Wall Street executives, and how functional medicine strategies can help you safely integrate it into a broader biohacking and longevity stack. This is a masterclass in hacking cognition and performance, designed for anyone who wants a sharper brain, stronger metabolism, and a more resilient body. You'll learn: • How Modafinil works as a nootropic without overstimulating dopamine • The connection between mitochondria, neuroplasticity, and human performance • Why Modafinil may protect against brain aging and inflammation • How to dose, stack, and cycle Modafinil with supplements and nutrition • What to expect from Modafinil compared to stimulants like Adderall or caffeine • The risks, side effects, and who should avoid it This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a transparent look at the world's most famous cognitive enhancer. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Modafinil, Armodafinil, Adrafinil, Real Limitless pill, Smart drugs, Eugeroic drug, Nootropics for focus, Orexin activation, Dopamine modulation, Mitochondria ATP production, Neuroplasticity enhancers, Jet lag treatment, ADHD alternative, Poker player focus enhancer, Modafinil stack, Modafinil and L-theanine, Modafinil and NAD+, Modafinil side effects, Stevens Johnson syndrome risk, Alzheimer's prevention modafinil Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:22 — Origin of Modafinil • 3:48 — Personal Experience • 8:22 — What to Expect • 9:37 — What Is Modafinil • 16:09 — How Modafinil Works • 19:36 — Benefits & Cognitive Upgrades • 25:36 — Dosing, Stacking, and Usage Tips • 28:17 — Side Effects and Safety • 31:37 — Sourcing and Legal Aspects • 36:55 — Research and Future Uses • 42:17 — Stacking for Biohacking • 47:07 — Recap and Final Advice See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today, I'm sitting down with Alex Tarnava and Dr. Tyler LeBaron, two of the brightest minds pioneering the use of molecular hydrogen in health optimization. Alex, the innovative creator behind the open cup hydrogen tablet technology, and Dr. LeBaron, founder of the Molecular Hydrogen Institute, join me to shed light on why this tiniest molecule could be the secret weapon in your longevity toolkit. We dive into their personal stories—Alex's relentless search for relief from autoimmune symptoms, and Dr. LeBaron's early curiosity that led him to decades of hydrogen research and advocacy.   To learn more visit  inhaleh2.com/NAT. There is a special discount between 20% - 24% percent off, depending on your pre-order.   Episode Timestamps: What is molecular hydrogen? ... 00:00:31 Guest backgrounds and early hydrogen research ... 00:04:37 Hydrogen's biological role and health benefits ... 00:09:24 Alex's personal health journey and invention ... 00:16:24 Clinical trials and real-world benefits ... 00:26:01 Hydrogen as a selective antioxidant ... 00:34:20 Inflammation, mitochondria, and aging ... 00:45:47 Delivery methods: water, inhalation, bathing ... 00:58:16 Dosing tips and protocols ... 01:14:21 Inhalation machines: safety and efficacy ... 01:17:47 Safety, final advice, and resources ... 01:26:26   Our Amazing Sponsors: StemRegen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   Puori - It's minimally processed, made from pasture-raised cows' milk, and it's tested for over 200 contaminants every single batch. Go to Puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you'll get nearly a third off the price. OraltidePro- A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at Ketone.com/vanessa. In this powerful second interview, Dr. Latt Mansor returns to the podcast to share his personal 20+ lb fat loss transformation—and how he used ketones and strategic carb re-feeds to break through stubborn plateaus, curb hunger, and preserve lean muscle mass. NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with magnesium and vitamin B12. Get 20% off at puori.com/VANESSA We dive into: How to use ketones to improve fat loss quality (not just scale weight) Why Dr. Mansor says ketones helped him “lose fat without losing muscle” How carb re-feeds helped him overcome plateaus and support metabolic flexibility How ketones support appetite control, recovery, and training performance A new study showing ketones boost sprint output and reduce fatigue Ketones vs. GLP-1 drugs like Ozempic—how they compare for appetite suppression Dosing protocols for fat loss, fasting, and late-night cravings How ketones improve oxygen delivery, red blood cell production, and reduce cortisol The science behind ketones reducing muscle protein breakdown and supporting performance Ketones and the brain: supporting focus, anxiety, ADHD, and GABA signaling If you've hit a fat loss plateau—or want to preserve muscle while losing fat—this episode is packed with cutting-edge science and tools on how to use exogenous ketones and strategic carbs to support metabolic health, performance, and sustainable results. Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Karen tackles a listener question about low-dose lithium. She reviews micro- vs. low-dose ranges, discusses forms like lithium orotate/aspartate and third-party-tested supplement options, and flags safety essentials such as toxicity symptoms, thyroid/kidney considerations, and when to loop in your clinician.Visit our website itchyandbitchy.com to read blog posts on the many topics we have covered on the show.