Podcast appearances and mentions of smith lemli opitz

A note from Paul: Throughout my training and practice as a physician, I have come to one very disappointing conclusion:  Western medicine isn't helping people lead better lives. Now that I've realized this, I've become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you'll join me on this journey. Today, Paul shares why he does not feel that his elevated LDL is a problem and why you may reconsider your doctor's suggestion that your elevated LDL cholesterol is too high. He also explains how to become insulin sensitive. Time Stamps: 00:09:58 Podcast begins 00:12:45 Fish consumption linked with melanoma 00:17:22 The sun is not harmful to humans  00:18:25 What is cholesterol? 00:31:33 Smith-Lemli-Opitz syndrome 00:34:15 Why Paul doesn't worry about his “elevated“ LDL 00:36:40 LDL does not injure the endothelium of our cells 00:39:30 How do we know if we are insulin sensitive/insulin resistant? 00:40:30 Cases of atherosclerosis without elevated LDL 00:58:50 Lipids & the immune system 1:00:00 Foods for healthy cholesterol and insulin sensitivity  1:01:30 Testimonial on removing seed oils Sponsors: White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Bon Charge:  https://boncharge.com, use code BONCHARGE for 25% off your order Eight Sleep: www.eightsleep.com/carnivoremd to receive exclusive Fourth of July savingsCalima Salt: bit.ly/carnivoresalt,  for a free bag of Calima Sea Salt

durée : 00:02:31 - Les Francs Comtois sont formidables - FB Belfort - Tous ensemble pour Raphael, une association qui aide le petit Raphaël atteint du syndrome Smith Lemli Opitz à suivre et financer les thérapies dont il a besoin pour évoluer

Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.   Time Stamps: 0:09:44  Podcast Begins 0:11:00  Lifestyle change and the power of animal foods 0:16:38  Is red meat killing us?   0:19:32  Humans are not hebivores  0:24:31  The problem with mainstream cardiology 0:31:03  The full story of LDL [and oxidized LDL] 0:38:22  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 0:43:23  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/  0:43:50  Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients  https://www.sciencedirect.com/science/article/abs/pii/S0009308497000959?via%3Dihub 0:44:44  Linoleic acid is at the root of heart disease   0:50:08  LDL and immune health 0:58:06  Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors  https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196 1:00:11  Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease  https://www.nejm.org/doi/full/10.1056/nejmoa1615664 1:02:05  Serious adverse events and deaths in PCSK9 inhibitor trials reported on Clinical  Trials.gov: a systematic review  https://www.tandfonline.com/doi/full/10.1080/17512433.2020.1787832 1:02:56  The dark truth of PCSK9 inhibitors 1:05:12  Metabolic health is what matters   1:07:04  Metabolic health is what matters   1:08:07  Let' change the paradigm! 1:13:21  Dr. Nadir Ali's health optimizaton advice 1:18:12  Where to find Nadir Ali MD 1:22:48  Binding and Partial Inactivation of Staphylococcus aureus a-Toxin by Human Plasma Low-Density Lipoproteinhttps://www.jbc.org/content/258/9/5899.long 1:23:18  Why you should rethink your statin 1:26:24  The Framingham Study 1:26:56  High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf 1:28:51  Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity  https://pubmed.ncbi.nlm.nih.gov/12951168/ 1:29:44  LDL size matters 1:31:24  Clinical Effects of Cholesterol Supplementation in Six Patients With the Smith–Lemli–Opitz Syndrome(SLOS)  https://www.researchgate.net/publication/14184407_Clinical_effects_of_cholesterol_supplementation_in_six_patients_with_Smith-Lemli-Opitz_syndrome_SLOS 1:32:56  Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005588/ 1:34:19  Determination of lipid oxidation products in vegetable oils and marine omega-3 supplementshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118035/ 1:34:29  Stop your omega-3 supplement!   Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram  Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order!    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order   White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order! Nutrisense: Nutrisense.io

Show Notes: Background on Megan: Megan is a pediatric nurse practitioner and lactation consultant, living in Minneapolis, MN. She lived in Washington, DC for several years and moved back to Minnesota to be close to family and friends. Megan is the mother of two wonderful children. While pregnant with her son, she discovered that her husband and she were both genetic carriers of Smith Lemli Opitz Syndrome (SLOS), a rare but devastating disease. After their son was born they grew their family through adoption, which opened her mind and heart to the many ways people grow their family. She is currently in the process of starting her own lactation business to help new moms on their breastfeeding journey. What we talked about: How and when she and her husband decided they wanted to start having kids What it’s like being a pediatric nurse practitioner and having friends/family reaching out as a resource and how it impacts her when her own kids are sickBecoming a lactation consultant and the most common problems she sees in new moms with breastfeedingHer own experience breastfeeding her son and dealing with his food intolerances Taking the leap into starting her own lactation business Balancing starting her own business with being a stay-at-home momHow her and her husband decided on adoption to grow their family What it was like finding out that she and her husband were both carriers of a genetic disorder - Smith-Lemli-Opitz syndrome Their journey from IVF with PGD to adoption Benefits of open adoptionsHow she talked about adoption with her 2-year-old son while they were going through the adoption process Finding out that they had been matched with their daughterMeeting their daughter’s birth mom Living in another state until they were cleared to leave with no support system and a 2-year-old and newborn while her husband was still workingHer relationship with her daughter’s birth parents The guilt that came with adoption Advice for those starting the adoption process Her go to for self-care both pre and post COVIDTrying to be more positive during COVID and finding a routine, especially as they go into colder months Connect with Megan at parklactation.com. Follow the Mommin’ podcast on InstagramThanks so much for listening and for supporting our podcast! Please leave a review if you liked what you heard and make sure to subscribe on iTunes, Spotify or Stitcher!

In this episode, Sal speaks with plant based advocate Dr. Will Bulsiewicz and carnivore advocate Dr. Paul Saladino. An interview with Dr. Will Bulsiewicz.  Is Will pro-plant based or pro-vegan? What are the differences? (4:42) How the food he was eating was holding him back. (6:37) How a plant-based diet allows you to activate satiety hormones to get into a calorie deficit. (11:16) Making the case for protein, the most satisfying macronutrient. (13:10) The educational problems surrounding planet-based diets. (16:22) Having the evolutionary conversation around eating meat. (18:05) Is longevity engineered? (22:57) Has he run into any clients who don't do well on a plant-based diet? (27:07) His take on creatine. (29:31) Does meat by itself post any health risks? (33:15) Looking at the layers of evidence. What's the deal with this TMAO? (35:35) Is it possible to build muscle on a plant-based diet? (37:45) His take on veganism being linked to higher rates of mental illness. (41:16) An interview with Dr. Paul Saladino. (43:35) What is the carnivore diet? (44:14) Why does he believe that plants are bad for us? (47:22) Doesn't processing vegetables get around their toxins? (52:22) Explaining the plant toxicity spectrum. (56:17) What's up with fiber?! (1:01:21) The effects of no vitamin c in our diet. (1:06:55) The mainstream dogma surrounding saturated fat. (1:09:55) Debunking the blue zones. (1:19:37) The role of carbohydrates when it comes to athletic performance. (1:23:14) Mind Pump Recap and Key Takeaways: Carnivore vs. Vegan. (1:27:28) Featured Guest(s)/People Mentioned Will Bulsiewicz MD MSCI (Dr B) (@theguthealthmd)  Instagram Dr. Will Bulsiewicz | The Gut Health MD Paul Saladino, MD (@carnivoremd)  Instagram Carnivore MD IFBB Pro Jehina

Question: Could low LDL hurt female fertility? I haven't seen evidence of it, but that would not surprise me at all given that cholesterol is what you make sex hormones from. If you see levels that low, I don't know that it's intrinsically a problem. You kind of want to start looking at what are the reasonable things you could expect to happen from that that affect female fertility? Fat-soluble vitamins could be relevant. Sex hormones could be relevant. I'd start looking at those things. I doubt that the LDL being that low itself in and of itself is going to be the thing that compromises fertility. This is the thing. Is the LDL low because of really good clearance from the blood, or is it low because of really low production? If it's low because of really low production, then you definitely have problems with fat-soluble vitamin transport. Because if the liver is not making lipoproteins as much, the fat-soluble vitamins are staying trapped in the liver and they're not getting to other tissues that need them. While there's no evidence for it, it makes perfect sense that dietary cholesterol would help that because dietary cholesterol is very helpful in Smith-Lemli-Opitz syndrome, where the exact same defect is 1,000X to produce a devastating result. It makes total sense that in someone who is a carrier for SLOS, Smith-Lemli-Opitz syndrome, who has defective cholesterol synthesis in their gonadal tissues and therefore has defective sex hormone synthesis, it makes total sense of eating cholesterol would help those people. So, I would try it. Egg yolks. That's what most people are going to eat for cholesterol. But this all hinges on the question of the LDL is low, so what? Is it because it's being cleared rapidly or because it's not entering the blood due to lack of synthesis? Whether that person is going to have infertility as a result of it and whether that's going to be helped by dietary cholesterol, it's all going to get a hinge on that. But the good news is for both people, it's probably completely harmless to eat some eggs. Eating eggs might just be the thing that helps. This Q&A can also be found as part of a much longer episode, here: https://chrismasterjohnphd.com/podcast/2019/03/30/ask-anything-nutrition-march-4-2019 If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

Maja och Nina träffar Lotta Frécon, vars 12-åriga dotter har Smith-Lemli-Opitz syndrom. Lotta var för ganska länge sedan i en liknande fas som Maja och Nina och berättar här om sina erfarenheter.    

Runt om i Sverige finns många barn som har ett syskon med en funktionsnedsättning. Många syskon tar ett stort ansvar hemma och kan kanske ha svårt att själv ta plats i familjen. Vad är viktigt för syskonen och vad ska man tänka på som förälder? Vi träffar åttaåriga Tuva som är syster till Vilma som har den sällsynta diagnosen Smith-Lemli-Opitz syndrom (SLO) och deras mamma Lotta Frécon. Gäst är även Jenny Rosendahl, kurator på Habiliteringscenter Liljeholmen, som håller i syskongrupper.

What is cholesterol? Cholesterol is a waxy, lipid in every cell’s membrane and our blood plasma, vital for life It insulates neurons Building cellular membranes Metabolizing fat soluble vitamins Produces bile to help digest food Synthesis if many hormones including sex hormones There are rare genetic disorders in which people cannot properly synthesize cholesterol.  Once such disease is Smith-Lemli-Opitz syndrome (also called “SLOS,” or 7-dehydrocholesterol reductase deficiency) which is a metabolic and congenital disorder leading to a number of problems including autism, mental retardation, lack of muscle, and many others. You get some cholesterol from the your diet and some your body makes. Cholesterol is different day to day All Cholesterol is NOT created equal. The tests your doctor runs do not tell the whole story Many (not all) people will have increase in cholesterol on a high fat diet but most studies show IMPROVED cholesterol profiles (inc in good cholesterol, decrease in bad) So the AHA is right. Saturated fat does increase cholesterol. But does this mean it increases heart attack?  Probably depends what you are eating the saturated fat with and your genetics. The good (HDL), The bad (TG) and The ugly (LDL) HDL (the Good) Transfers excess cholesterol that tissues don’t use back to liver Liver excreted through bile HDL is the one to naturally help get rid of excess cholesterol when the body’s done with it, You want it as high as possible Increased by LCHF / Keto Triglycerides: (THE BAD) (causes fatty liver and heart disease) TG are fuel for your body High TG in blood because your body is not using it Its using glycogen instead If fat adapted - you are using this up TG just sit  around and cause problems TG float around in circulation Because hard and dense and causes problems/ plaques It starts to get oxidized Damaged and clogged arteries Your body tries to clear it with local inflammation Cells responding to inflammation cause plaque and clog arteries Arteries are narrowed and less blood and less oxygen TG increase small dense LDL LDL: (the ugly) - because its complicated LDL delivers cholesterol to tissues. Large fluffy LDL does this SO IMPORTANT LDL-C (large and fluffy) and LDL-P (go to artery walls and clog) ApoB (a proxy for LDL-P which not many labs run) Apolipoprotein B (ApoB) is an important component of many lipoproteins that are involved in atherosclerosis and cardiovascular disease. Apo B containing lipoproteins are the ones that are most likely to enter the wall of the arteries. TAKE HOME If you are not going to change your lifestyle and eat high sugar diet and you have heart disease - you might want to take a statin If you eat low carb high fat your cholesterol panel will be different then someone on a SAD Make sure you get the break down of particles to get a better picture Currently, most people in the United States (and the world for that matter) undergo a “standard” lipid panel, which only directly measures TC, TG, and HDL-C.  LDL-C is measured or most often estimated HIGH Triglycerides is BAD HIGH HDL is GOOD LDL-C is large fluffy and healthy GOOD LDL-P vs ApoB is small and dense and bad LDL-P (or apoB) is the best predictor of adverse cardiac events, which has been documented repeatedly in every major cardiovascular risk study When looking for information look to lipidologists who have phDs in this stuff not correlational / drug company funded research (mostly what doctors are aware of) https://idmprogram.com/diet-heart-hypothesis-hormonal-obesity-xxxv/ https://peterattiamd.com/the-straight-dope-on-cholesterol-part-i/ http://eatingacademy.com/cholesterol-2/the-straight-dope-on-cholesterol-part-iii cbi.nlm.nih.gov/pubmed/27389628 https://www.marksdailyapple.com/cholesterol/ https://www.medicalnewstoday.com/articles/267834.php https://www.healthline.com/nutrition/23-studies-on-low-carb-and-low-fat-diets http://clinchem.aaccjnls.org/content/50/10/1725

Muchas veces las personas No muestran su lado humano, por cuidarse el branding personal, lo mejor es mostrar quien eres, por que con ese profesional es el que desea trabajar tu cliente o futur cliente. Fuentes : Musica y Autor : Catch The Wind by Donovan https://open.spotify.com/track/3uJhF1XGOJ27hweKEeBOtk Info acerca de Smith Lemli Opitz : http://www.smithlemliopitz.org/

Muchas veces las personas No muestran su lado humano, por cuidarse el branding personal, lo mejor es mostrar quien eres, por que con ese profesional es el que desea trabajar tu cliente o futur cliente. Fuentes : Musica y Autor : Catch The Wind by Donovan https://open.spotify.com/track/3uJhF1XGOJ27hweKEeBOtk Info acerca de Smith Lemli Opitz : http://www.smithlemliopitz.org/