Podcasts about ldl p

In this eye-opening episode of the Fusionary Health Podcast, Dr. Shivani Gupta welcomes Dr. Tracy Gapin, a trailblazer in men's health and performance optimization. As a board-certified urologist and founder of the Gapin Institute, Dr. Gapin has spent over two decades refining personalized health strategies for high-performing individuals, from executives to athletes. Drawing on his extensive experience and his best-selling books Male 2.0 and Codes of Longevity, Dr. Gapin dives deep into the science and solutions behind the most pressing issues in men's health today. What You'll Learn:   The Silent Saboteurs: Discover how everyday toxins like phthalates and BPA are stealthily undermining men's health by disrupting hormones, leading to widespread issues such as low testosterone, infertility, and obesity. The Testosterone Epidemic: Uncover why testosterone is the unsung hero of men's health, vital for everything from energy and focus to metabolism and heart health, and learn why its decline is now a national crisis. Mastering the Fundamentals: Before reaching for advanced therapies like peptides, learn why foundational habits—sleep, nutrition, and stress management—are the true cornerstones of long-term health. The Future of Personalized Health: Explore how wearable tech and biometric data are revolutionizing the way men approach their health, offering tailored solutions that deliver real, measurable results. Gut Health: The Hormone Connection: Understand the critical role gut health plays in maintaining hormonal balance and why gut dysbiosis could be the hidden culprit behind your health struggles. Sleep: The Ultimate Performance Enhancer: Learn the secrets to optimizing deep and REM sleep, crucial phases for muscle recovery, fat loss, memory consolidation, and hormone regulation. Beyond Cholesterol: Get the truth about advanced cardiovascular tests like ApoB and LDL-P, and why these markers are far more telling than outdated cholesterol metrics. Peptides: The Cutting-Edge Advantage: Dive into the world of peptides—potent tools that can enhance everything from immune function to cognitive performance—when used as part of a comprehensive health strategy. Data-Driven Decisions: See how real-time health monitoring, such as continuous glucose monitoring, can reveal surprising insights and guide you toward smarter health decisions. Stress Less, Live More: Discover practical stress management techniques, from meditation to breathwork, that lower cortisol levels and boost overall well-being, paving the way for a healthier life.   Why You Should Watch: This is not just another health talk. This episode is your gateway to a new understanding of men's health—one that's data-driven, personalized, and profoundly transformative. Dr. Tracy Gapin's insights go beyond conventional wisdom, offering you the tools to take proactive control of your health and maximize your potential. Whether you're a driven professional, an athlete, or someone seeking to improve your life, this conversation will equip you with actionable strategies that make a real difference. Transform your approach to health and performance with the expert guidance of Dr. Tracy Gapin. Share this episode with anyone who's ready to take charge of their health and unlock their full potential. Learn more about our host visit: www.shivanigupta.com Show sponsored by Fusionary Formulas. Visit www.fusionaryformulas.com use code FUSIONARYHEALTH for 15% off your entire order. #MensHealth #PerformanceOptimization #TestosteroneHealth #DrTracyGapin #FusionaryHealthPodcast #HealthOptimization #HolisticHealth #HighPerformanceHealth #MaleHealth #WellnessJourney #Testosterone #EndocrineDisruptors #WearableTechnology #DataDrivenHealth #Peptides #StressManagement #SleepHealth #GutHealth #Biohacking #Longevity #PrecisionMedicine #DrShivani Gupta  

Dave Feldman is the founder of the Citizen Science Foundation and is known for his research into the ketogenic diet. Dave is a software engineer by training who embraced a ketogenic diet to avoid his progression toward type 2 diabetes. he joins us on this episode of STEM-Talk to share that journey. After undertaking the high-fat/low-carbohydrate diet, Dave' LDL cholesterol spiked. Dave used his training as an engineer to start learning everything he could about cholesterol and lipids. What he learned led him to create the website Cholesterol Code, a research hub for information and emerging data on cholesterol, particularly in the context of a low-carbohydrate lifestyle. Dave's Citizen Science Foundation is designed to support projects and research that promote collaborative efforts across multiple disciplines, both in and outside formal scientific institutions. Show notes: [00:02:53] Dawn opens the interview asking Dave what he was like as a kid. [00:03:44] Dawn mentions that Dave divided his time as a child between Denver and Wichita due to his parents' divorce and asks Dave what the best part of his childhood was. [00:04:28] Ken mentions that Dave has described both his parents as graphic artists and Bohemian, “hippie spirit” types. Ken asks what he learned from them that fueled his interests and goals. [00:05:46] Ken asks about Dave's first computer, which was a Commodore 64, as well as his early experience with computers. [00:08:50] Dawn mentions that Dave's interest in computers came in a time before the internet and asks what he learned about computing in those days. [00:10:51] Dawn explains that since Dave grew up in the 1980s, there was not much in the way of computer science curriculum in schools and asks Dave how he supported his interest in programming. [00:12:33] Ken asks Dave about how self-directed learning has been a theme throughout his whole life. [00:14:35] Dawn asks Dave about his childhood hobbies, including running and competitive storytelling. [00:17:01] Ken asks how Dave's experiences in forensic debate in high school helped his career later in life. [00:18:56] Dawn mentions that Dave initially attended film school and asks if it is true that Dave's side hustle of doing contract software work overtook his original plan to graduate. [00:20:49] Dawn asks about Dave's experiences working in the game platform development business in Las Vegas, as well as what these experiences taught him. [00:22:23] Ken asks Dave about a “the piece of paper” that Dave says changed his life in 2015. [00:28:58] Ken follows up, asking Dave if he checked his LDL-P or his ApoB at the same time as his cholesterol levels. [00:30:37] Ken mentions that he knows some people that when consuming a ketogenic diet did not see a substantial increase in LDL-C, but did experience a substantial elevation of LDL-P. [00:35:03] Ken pivots to discuss a paper that Dave and others published in Current Developments in Nutrition in 2022 titled: “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for Lean Mass Hyper-Responder Phenotype.” Ken asks Dave to describe what it means to be a lean mass hyper-responder. [00:40:19] Ken mentions his caution against the term lean mass hyper-responder, as it is unclear what “lean mass” refers to in this case. Ken goes on to say that while the lean mass hyper-responder phenotype can be objectively measured in terms of LDL, HDL and triglyceride levels, the lean mass aspect is often measured in these studies with BMI, which is unable to measure body composition. Ken asks Dave what his thoughts are on this and if he would like the possibility of moving away from BMI and towards DEXA scans. [00:43:37] Ken mentions that Dave's original article describing the lean mass hyper-responder phenotype has received a lot of response from individuals claiming to fall into that category. While it is difficult to get a precise estimate of the popul...

Understand the vocabulary of cholesterol so that we are all on the same page and having the same conversation. What's the difference between LDL cholesterol versus LDL particles versus apolipoprotein B (ApoB)? LDL-C, LDL-P, ApoB, Lp(a) https://dralo.net/links

50% of men and 38% of women over the age of 60 are taking statins to lower their cholesterol. But, is this number too high? Are they being overprescribed? And, are there any dangerous side effects to taking them? Every cell in our body needs cholesterol, so there's certainly a significant downside to having not enough cholesterol. What about the fact that so many people who suffer heart attacks have low cholesterol? Some research shows it's about 50% the number of people with high vs low cholesterol who also suffer heart attacks. So cholesterol alone is certainly not a good indicator for your risk.  If you've been prescribed statins, did your doctor also do a CAC scan, or test your sdLDL, oxLDL, LPa, or LDL-P? It's these questions, and many more that you absolutely should be asking before you blindly fill your prescription and start taking statin drugs!

Please Subscribe and Review: Apple Podcasts | RSS Submit your questions for the podcast here News Topic:   Incident type 2 diabetes attributable to suboptimal diet in 184 countries Nina Teicholz twitter thread Show Notes:   Precision Health Reports Train with Morpheus Questions:    Weight gain, inflammation, cholesterol, cardio Becky writes: I am SO sorry about this length, I truly tried to whittle it down. I think I'm giving you too much information. :) I hope I don't disqualify myself over the length and also THANK YOU in advance for your help! Hi Robb + Nikki, I have been bingeing your podcast lately and as it turns out, I have a question (actually more than 1) for you. I am going to be 46 in June. I have worked over 25 years in restaurant kitchens, so a lot of physical work + standing on my feet all day. My husband and I reside on Cape Cod which is hot and swampy in the summer, therefore the kitchen environment is hot and swampy and depleting in every way. At age 34/35 I began going into perimenopause, and I have officially been in menopause since June 2022, at age 45. I tried for years to get my period back. I had been vegetarian/sometimes vegan for about 6 years and then I switched to Paleo intermittently for a few years. Plus Acupuncture, TCM, Plant Paradox, Medical Medium, dozens of Whole 30's, etc. I've tried it all, though none for more than a month or two. The past few years have found me 60 + pounds overweight (I am 5 3 1/4 and currently weigh 188-190.), sore, stiff, weak, with thinning hair, lack of mobility, and feeling depressed. I have sleep apnea and am going on one year with my magical C Pap machine though lately that has seemed to level off and I am waking up tired again. I had bloodwork done on January 31 that revealed high cholesterol and stagnant liver function, with glucose on the high level of normal which my doctor seemed to think was fine, 93/99. (TC 206; HDL 41; Trig 83; LDL 146; liver: AST 40; ALT 80). Also higher blood pressure than I've ever had, 138/80. Usually doctors exclaim over how great my blood pressure is! Determined to get my health and vitality back on track I re read your two books, Robb, (Wired to Eat and The Paleo Solution.) I decided to dive back into Paleo but cut out all carbs, and I had already been booze free since December. I started IF most days, started lifting weights a bit, but still avoiding cardio which I DESPISE When I increase the animal protein though, I tend to stop pooing regularly. I was vegetarian for a few years and had no problem moving things out but I feel that is what precipitated my descent into metabolic haywire. I have been supplementing lately with magnesium, minerals, Vitamin DAKE from Dave Asprey, some TCM herbs for liver support, and I've been on the lookout for a good digestive enzyme. I had given up coffee for nearly a year because it was making me hot and anxious, and I thought it was a factor in my hair shed, but lately I started mixing a little coffee back in to my Rasa along with collagen, which I just started using again. I started eating a lot of full fat cottage cheese for more protein, the only dairy that doesn't seem to make me phlegmy. Then the past few weeks, some wine here and there. I got my second round of bloodwork done on April 4 and my cholesterol went UP, though my liver improved. (TC 246; HDL 49; Trig 85; LDL 178; liver: AST 30; ALT 39). She didn't test my glucose again. I do have heart disease and high cholesterol in my family. Did my cholesterol go up from wine, even though my liver improved? Cottage cheese? Not really exercising? All of the above? After I read your books again I asked my doctor to authorize tests for my A1C, LDL-P, and CRP but she refused. Something about coding for insurance and blah blah blah. I see her again at the end of this month and I am hoping she will agree to the other tests after seeing my cholesterol jump. I have always been a giant ball of stress and nerves (don't ask me why I chose the worst possible career for that). I know I need to meditate and breathe better, and sometimes I do. I used to be stronger and fitter. My other issue is I tend to reject routine after a while. I have a terrible, terrible sweet tooth as well. I am my own worst enemy! My weight has yo-yoed constantly over my life, but this is the heaviest I've ever been. I gained 10+ pounds last spring, then jumped another 10 pounds between September and December. (In 2008 I was 130, right before going veggie.) A lot of my dilemmas ramp up next week as I return to work full time:  I work from 1-2 pm to 10-11 pm 5-6 days a week. Eating on the job is a no-no, although we all graze on the down low. I could take a break, in theory, but simply don't have time. Most shifts I don't have time to drink out of my water container right in front of me (I bring a gallon of water with 2-3 LMNT packs in it to work.) An average shift leaves me hot, sore, sticky, thirsty, and anxious. So in terms of IF and exercise: If I wake at, say, 9 am (and feel like absolute road kill, btw, and both feet are on fire from pinky toe bunions) and need to be clocked in at work by 1:30 or 2, that leaves me 4.5 hours to get all my meals in, exercise, AND spend time on soul fulfilling hobbies. I try very hard to not eat or have a drink when I get home from work, but sometimes I'm ravenous. (Or am I just dehydrated and anxious? They kind of feel the same.) And then as we slide into the busy summer season I'm having a drink every night… What, when, how much do I eat during the day? If I am going to eat after work, what type of macro situation should I have? I've thought about bringing meat sticks or homemade collagen gummies in to work, but then I'm snarfing them in the corner between tickets and I am most definitely NOT in a parasympathetic state, so in that case is it better to just be hungry?? Also the siren song of the bowl of salty french fries beckons all night, which we all pick out of. I feel like HIIT 3-4 days a week, heavier weights and less reps, with maybe a yoga class or two or three mixed in is what I need (although I need to actually DO it) but my husband thinks I need to jog for an hour 5 days a week and lift lighter weights with more reps. He says I need to do so much cardio that I puke. I'm not liking the sound of that. Is there a happy medium somewhere or am I just a whiny baby? I keep hearing you mention “zones” for cardio and I'm not sure what that means. You had a question regarding cholesterol a few weeks back, a man named James I think who cut out carbs and his cholesterol jumped as well. You recommended him adding a few more carbs. But I thought cholesterol came from dietary carbs? I miss fruit and potatoes and winter squash. I really miss the vibrant and energetic person I used to be, also. **Some reference points that may or may not be useful for you that you don't need to add to my question, or read out loud, but just in case you need more info along with the novel I've already written: We work in a seasonal restaurant so we have winters off, which is when I try to wrangle my health back in line before the slow slide into the madness of summer. I'm TIRED of this merry go round. I want to be healthy and sustain my vitality all year long. I have really good work shoes and orthotics only available at my podiatrist's office. Interestingly I had bunion surgery in 2001 for both my big toes. My newest bunions started paining me in late 2019. 2017 I had 4 menstrual cycles all year, then 2 each in 2018 and 2019, then my last one in May 2021. My cycles have been irregular throughout my whole life. I have never been pregnant. When this all began an older male doctor bullied me onto the pill. I stopped after a month because I felt WEIRD. I've not had Covid that I know of, but I did fall for the 3 jabs: April and May of 2021, and January 2022. Never again though. When I was very little I reacted badly to the DTP shot (lower body paralysis for a day after) so I was hesitant to get the C shot but didn't seem to get anything but a sore arm, knock on wood. I guess only time will tell with that situation. Did I mention tong-itis (the kitchen version of tennis elbow) in both arms? In 2017 it was so bad I couldn't shift the gears in my car. Basically I am just inflamed, stiff, tight, contracted. I know I need to stretch more or roll on my foam roller or fascia balls but then I think so much about what I need to do I don't do anything and I end up sitting in my chair all day, dreading work Sponsor: The Healthy Rebellion Radio is sponsored by our electrolyte company, LMNT. Proper hydration is more than just drinking water. You need electrolytes too! Check out The Healthy Rebellion Radio sponsor LMNT for grab-and-go electrolyte packets to keep you at your peak! They give you all the electrolytes want, none of the stuff you don't. Click here to get your LMNT electrolytes

On today's episode of Red Pill Your Healthcast with Dr. Charlie and Nurse Practitioner Lauren-  Pharma talk! Statins and blood pressure medications.   Let's dive in!   Connect with Dr. Charlie Website Instagram Membership   Connect with Nurse Practitioner Lauren  Website Instagram Email List Cholesterol Recs:  Paleo Cardiologist Book- Shop CoQ10- Shop ReGenerZyme® Heart- Shop InspiraCell®- Shop NMR profile Test Study about the Risk of Low Cholesterol - Read   Dr. Charlie Scale for Cholesterol Labs Total Cholesterol between 220-250 LDL below 120 HDL between 55-80 Triglycerides below 100 — Blood Pressure Redmond Salt- Shop Trace Minerals- Shop Magnesium Glycinate- Shop Magnesium Malate- Shop Coconut Water- Shop Magnesium Bicarbonate- Shop Use code naturalnursemomma for 10% off Dr. Charlie's Rec- Astragalus Supreme - immune builder. master tonic of Chinese Medicine Cat's Claw- lyme, parasite, yeast, Heart Health, etc - one of our favorites. Dan Shen- red sage, lowers blood pressure Artichoke Extract- regulate blood sugar   Tests for Erectile Dysfunction Blood Test for Lipoprotein (a), Fibrinogen, CRP, Homocysteine.   NP Lauren's Rec- Daily cup of strong Hibiscus Tea - Shop I buy I loose leaf tea or organic paper tea bags. To make loose leaf tea I usually do 1-2 teaspoons loose herbs in hot water and steep for 5 minutes. Add sweetener of choice.  Magnesium Blog- Read NMR lab test ranges Small LDL-P below 530 ideally, LDL-P below 1000 and LDL size above 20.5. If LDL a particles are small and dense they are more likely to cause issues.  Search full library of our favorite supplements - Lauren's Fullscript- https://us.fullscript.com/welcome/naturalnursemomma Dr. Charlie's Fullscript- https://us.fullscript.com/welcome/cfagenholz   One thing not mentioned in this podcast is the amount of seed oils in our foods has increased exponentially. These are in fact linked to inflammation and a contributing factor to high cholesterol. I do not stress about never eating vegetable or canola oil but I do try to eat whole foods and cook with other fats. I use grassfed butter, beef tallow, duck fat, etc.   Here are the brands I use in my home https://a.co/bacW2OL         Thanks for listening y'all!

This episode explains what a low carb diet does to LDL cholesterol. In it, I explain the difference between LDL-C (cholesterol) and LDL-P (particle number). One of the most common objections we hear about people not wanting to eat more animal products is a fear of their cholesterol going up. Much confusion exists over whether high LDL cholesterol is okay or not for your health. Often, physicians are prescribing statins based solely on total or LDL cholesterol numbers. This exposes people who may not actually need the medication to undesirable side effects including muscle aches, pain, fatigue, and increased insulin resistance. This video explains when that's okay, and how to actually know your risk of cardiovascular disease besides relying on total cholesterol or LDL cholesterol. As you'll learn, these are very poor indicators of your risk.Highlights From This EpisodeWhat is cholesterol?Difference between LDL-P (particles) and LDL-C (cholesterol).LDL Pattern A versus LDL Pattern B.Why LDL-P is more important than LDL-C when determining cardiovascular risk.Does high LDL cholesterol cause heart disease? + Why you shouldn't accept a statin based solely on high total or LDL cholesterol.Common side effects of statins on muscles and insulin resistance.Why you don't need to fear eating saturated fat.How to look at the research on low-fat diets.Why total cholesterol and LDL cholesterol go up on a low-carb diet.  Subscribe & ReviewSubscribing and leaving a rating and review are important factors in helping the Reshape Your Health Podcast and the YouTube Channel reach more people. If you haven't already subscribed, please do that today.We would also be grateful if you left a rating and review, too. In your listening app, scroll to the “Ratings and Reviews” section, then click “Write a Review” and let us know what you enjoy about our show. We appreciate you taking the time to show your support. Thank you!Resources From This Episode>> Join Zivli>> Book a Free Zivli Discovery Call>> Freebie: Weight Loss Mindset Audio Training>> Freebie: The Ultimate Food Guide>> Watch This Episode on YouTube>> Carol's Fibromyalgia Story>> What Is A Good Insulin Level & How to Interpret Your Bloodwork Episode >> *NEW* FREE TRAINING: How to Lower Insulin Resistance: 5 Keys to Lower Blood Sugar, Lose Weight, and Keep it Off

On today's episode, Dr. Jaime interviews  Engineer and Entrepreneur, Dave Feldman. "I'm a senior software engineer and entrepreneur.I began a low-carb, high-fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that's very similar to distributed objects in networks.I've since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data (see my Cholesterol Code series Part I, Part II, Part III, Part IV, and Part V).As of this writing, my “Extreme Drop” experiment has gotten the most attention (see infographic here, and do-it-yourself page here) where I induced a 73 point drop in my LDL-C and a 1115 point drop in my LDL-P."Holistic Life NavigationThis podcast explores how to heal stress & trauma holistically. I am your host, Luis...Listen on: Apple Podcasts Spotify A Little Bit of ChillFun, light-hearted Podcast full of self-help and suggestions to help you find your chillListen on: Apple Podcasts Spotify This Queer Book Saved My Life!We interview queer guests about the LGBTQ books that saved their lives.Listen on: Apple Podcasts Spotify

Short answer: If inflammatory markers are low and Lp(a) is proportionally more elevated than LDL-P, then blood lipids probably account for part of the calcification, while factors impacting LDL oxidation come next and those impacting calcification directly come after that. For the latter two, the oxidative stress and calcium sections of the Cheat Sheet should be consulted. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Quinta Com Nutrição é uma série de episódios semanais gravados com o Felipe Viana, do @DensaNutricao. A Ideia é fazer um podcast divertido, simples, tratando sempre te assuntos atualizados. Felipe Viana, Acadêmico de Nutrição, economista e baterista em uma banda de Rockabilly. Felipe é ex-obeso. Com apenas 27 anos pesava 110Kg e já estava usando estatina e glifage. Tinha o ácido úrico alto e a sua saúde estava destruída por um estilo de vida insalubre. Depois que conheceu a Low Carb, Felipe mudou completamente sua vida, perdeu 25kg e decidiu fazer nutrição. Hoje ele mantém o instagram @Densanutricao onde ensina sobre uma alimentação adequada de forma irreverente e divertida. Henrique Autran, também Acadêmico de Nutrição, ex professor e marombeiro. Henrique é apaixonado pelos estudos, lê em média 50 livros por ano e devora artigos científicos. Ele é o autor do ebook Cozinha Ancestral que conta com receitas ancestrais da @ChefGabrielaCarvalho e criador do Movimento Rebelião Saudável. Apesar de nunca ter sido gordo e sempre ter tentado ganhar peso, Quando descobriu a Low Carb, emagreceu 10Kg e mudou completamente a composição corporal. Através do seu instagram (@HenriqueAutran) consegue ajudar milhares de pessoas sempre com informações científicas explicadas de forma simples. Conversamos sobre: 1. A Nova Rotulagem de Alimentos No Brasil Exemplos no Mundo: Chile, Israel, Uruguai, México e Peru: Redução de 24% na compra de refrigerantes; Retirada de Figuras Infantis; NutriScore: Quando a rotulagem dá errado As Regras Brasileiras: Rotulagem Frontal: Alertas contra açúcar, sódio e gordura saturada; As Regras Brasileiras: Nova Tabela de Informação Nutricional: Porções por embalagem, Porções em 100g ou 100ml para facilitar comparação, Açúcares adicionados Nossa avaliação dessa nova rotulagem: Coma Comida de Verdade! Evite Rótulos! Fontes: https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2020/aprovada-norma-sobre-rotulagem-nutricional https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2020/aprovada-norma-sobre-rotulagem-nutricional/apresentacao-rotulagem-nutricional_19a.pdf 2. Colesterol e Aterosclerose: Novos Paradigmas O que é colesterol? Qual a Importância dessa molécula? Por que o colesterol foi vilanizado? As Lipoproteínas: VLDL, LDL, HDL, Quilomícrons Metabolismo das Lipoproteínas Exames de Sangue e as relações entre os valores As Hipóteses de formação da Aterosclerose: LDL como causador, Glicocálix, Hidrodinâmica, Vasa Vasorum Por que não existe aterosclerose em Veias? E se colocarmos uma veia num lugar de uma artéria? LDL-C, LDL-P, Lp(a), LDL Oxidado (oxLDL) e omega 6 Hiperinsulinemia e Padrões de LDL (A e B) Se você gosta de nosso trabalho, deixe um review 5 estrelas e faça um comentário no seu app de podcast. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas. Você pode dar suporte para todo nosso investimento de tempo nos apoiando via Patreon. Assim poderemos continuar a oferecer a você conteúdo de qualidade sem anúncios e de forma totalmente gratuita. Visite: http://www.patreon.com/rebeliaosaudavel Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran. E em nosso canal do YouTube: https://youtube.com/c/henriqueautran. Estamos também no telegram com um grupo exclusivo que você pode participar. Lá no telegram eu consigo compartilhar materiais exclusivos que não dá para compartilhar no Instagram. Você pode acessar o grupo no telegram em https://t.me/RebeliaoSaudavel.

Trying To Avoid Statins, Autoimmune Hepatitis, Chronic Low Back Pain - Supplementation, Still Holding Body Fat Even An A Keto Diet, Shaky Legs and Lactate Make your health an act of rebellion. Join The Healthy Rebellion Please Subscribe and Review: Apple Podcasts | RSS    Submit your questions for the podcast here   Show Notes: News topic du jour: Some sparkling water brands have PFAS chemicals, study finds https://www.cbsnews.com/news/pfas-chemicals-in-sparkling-water-polar-topo-chico-study/ 1. Trying To Avoid Statins [27:54] Gabe says: Hey Robb and Nicky, I was wondering if you could offer some guidance regarding some of the best things I can do to improve my cholesterol.  I recently had a standard lipid panel done that showed that my LDL-C was calculated at 154.  Total was 234, HDL was 60, and Trigs were 93.  I'm having more comprehensive blood work done by my functional medicine doc to get a measure of apoB and LDL-P.  But during my appointment he brought up the possibility of statins.  I'd like to avoid that if at all possible and was curious if your work with Specialty Health gave you some insight as to what interventions generally worked best for folks.  Some of the research I've been doing from Peter Attia seems to indicate that cholesterol is largely just a function of how much your cells produce and how many hepatic LDL receptors your genetics blessed you with which makes me feel pretty powerless. Just for reference I'm 42, and have eaten more or less along ancestral guidelines for the past 8 years with some very occasional minor offenders like oats, beans and corn.  I exercise very inconsistently...kind of a 3 months on, 3 months off pattern which consists of mainly of 5x5 powerlifting.  I'm also coming off a year of being stuck in an office with a lot of recent college grads which meant a good bolus of donuts, pizza, and other non-sanctioned foods which started infiltrating my day to day.  But I've changed work situations now and eating is much more on track for the last couple months.  I'm 5' 11", 170 lbs, and perpetually squishy around the mid-section. Any thoughts are appreciated. Gabe https://www.nature.com/articles/s41598-018-38461-y#:~:text=2)%2C%20the%20TC%20ranges%20associated,%E2%80%93220%20mg%2FdL). In the spline analysis (Fig. 4, Supplementary Fig. 2), the TC ranges associated with the lowest mortality were approximately 200–240 mg/dL, except for men at 18–34 years (approximately 180–220 mg/dL) and for women at 18–34 years (approximately 160–200 mg/dL) and at 35–44 years (approximately 180–220 mg/dL). 2. Autoimmune Hepatitis [33:57] Ben says: You were one of the first people I started listening to when I began my journey towards living a clean lifestyle. I heard your name pop up through Katy Bowman. I have a female friend, 20 years old, who just got diagnosed with autoimmune hepatitis. I haven't read much about it in the past and haven't heard much about it on various podcasts. A google search doesn't make a compelling argument for other ways to manage it besides steroids. Besides the obvious, (improve sleep, limit stress, avoid alcohol, exercise, eat an autoimmune style diet) is there anything specific that would help target the disease? Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction 3. Chronic Low Back Pain - Supplementation? [37:05] Matthew says: Hey Robb and Nicki. I have been listening for a while and also caught you (Robb) on Joe Rogan when you spoke a little bit about your chronic back pain. I've had mine for about 5 years thanks to a desk job and poor deadlift, squat technique (subsequently corrected). My question is if there is any supplementation (Kratom?, CBD?) or specific protocols you find working. For context I crossfit 5 days a week, yoga once a week, mobility work 15 mins a day, use a standing desk almost exclusively, daily walks, and have been eating clean for almost a decade. I think I have the basics down and seeing if you have extra tips. I'd love to be able to not have to scale deads and squats some day down the road We mentioned the folks at Basis Health and Performance in this answer. Try their strength program free for a week http://basishp.mykajabi.com/   4. Still holding body fat even on a Keto diet [49:41] Martin says: Okay so about a decade ago I lost over 80 lb going on a Paleo Diet and I was very happy and feeling in the best health I ever have since I was a teenager. I am now 54 and eat a mostly keto diet with very very occasional cheats and when I do that it's on a Paleo kind of platform. However I am just not satisfied with my body composition and maybe it's dysmorphia or something like that but I don't have that cut or ripped look. I can do a lot of pull-ups, I do a lot of powerlifting type lifting, I'm very strong, but I look like I still have subcutaneous body fat which is near impossible to shed and especially around my chest where I try to get a defined but I still have these rules what appears to be at on the very corners of my Pecks near my armpits am I just being silly or is there something I can do to get a more ripped lean look? thank you for your consideration   5. Shaky Legs and Lactate [55:03] Caroline says: Hello Rob and Nikki. Can't believe this is my first question for you as I've been following your work since 2009. I usually do my own research but this time I really need help. I've been starting to get shaky legs (!) when I do for example shoulder press or biceps curls. Never been especially prone for lactic acid (lactate) buildup before even as I was exercising much more intensely. This worries me. I read that lactate is produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation both during normal metabolism and exercise. But why do I get so much of it after only a two minute session? I recently also learned that LDH is a good indicator of cancer, in its early stage. Does this mean that people with beginning cancer also get more lactic acid? I'm hoping you can help to clear the correlation between the two and what other factors could possibly be contributing to my legs shaking when doing upper body workout! Short facts: Female age 36 170 cm, 55 kg Hashimoto (but under control) Keto, carnivore-ish Lyme disease one year ago (doxycycline for 21 days) Thank you so much! Hugs from Sweden Caroline   Sponsor: This episode of The Healthy Rebellion Radio is sponsored by White Oak Pastures. White Oak Pastures is a six-generation, 154-year-old family farm in Bluffton, GA. They pasture-raise 10 species of livestock and practice regenerative agriculture that improves the land. Their cattle and sheep are grassfed, their pork and poultry are pasture-raised and given non-GMO feed. All their meats are raised, slaughtered, and butchered on the farm. They also sell organic vegetables, pasture-raised eggs, honey, pet chews, leather items, tallow goods, and more artisan products that they make on the farm. They are committed to animal welfare, land regeneration, and rural revival. Check them out at http://whiteoakpastures.com/robbwolf and enter code REBEL10 to get 10% off product total ($100 max discount) for first-time customers.  

Podcast Notes Key Takeaways Atherogenic lipoproteins are now widely recognized as the driver of atherosclerosisSmoking and hypertension are two of the biggest risk factors for cardiovascular disease“The causal relationship between apoB and atherosclerosis is as strong as anything we see in medicine.” – Peter AttiaThe overwhelming majority of people with low HDL have a high apoB which drives atherosclerosis Lp(a) represents the single greatest driver of atherosclerosisEveryone should be tested for Lp(a) once in their lifeStatin contribution to atherosclerosis reduction is likely because of apoB reductionRead the full notes @ podcastnotes.orgWorld-renowned lipidologist Tom Dayspring returns to give an update on the current thinking in lipidology as a follow-up to his 2018 five-part podcast series. In this episode, Tom discusses the growing consensus that atherogenic lipoproteins are essential drivers of atherosclerotic vascular disease. Tom further emphasizes apolipoprotein B (apoB) and lipoprotein(a) (Lp(a)). He provides insights into risk assessment, including which lab metrics to use, how to interpret them, and the appropriate therapeutic targets. Additionally, Tom discusses the most recent developments in lipid-lowering drug therapies—from the continued evolution of PCSK9 inhibitors, to the latest understanding of EPA and DHA, and the most recent addition of bempedoic acid to the list of therapeutic agents. We discuss: The latest in the field of lipidology and cardiovascular disease [3:45]; Apolipoproteins—the key to understanding lipid biology [9:30]; ApoB as a preferred metric over LDL-P [16:30]; Therapeutic goals for apoB concentration [21:45]; Drivers of atherosclerosis [34:15]; Overview and current thinking on high density lipoproteins (HDLs)—Is it a useful metric? [37:00]; Lipoprotein(a)—the most dangerous particle you’ve never heard of [55:00]; Are low density lipoprotein triglycerides (LDL-TGs) a useful metric? [1:13:15]; Tom’s preferred lab measurements [1:17:45]; The latest in lipid-lowering therapies [1:21:30]; The different pathways among various lipid-lowering drugs [1:30:45]; The latest on EPA and DHA [1:38:15]; Fibrates—an underappreciated treatment for hypercholesterolemia [1:49:45] and; More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/tomdayspring6  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

World-renowned lipidologist Tom Dayspring returns to give an update on the current thinking in lipidology as a follow-up to his 2018 five-part podcast series. In this episode, Tom discusses the growing consensus that atherogenic lipoproteins are essential drivers of atherosclerotic vascular disease. Tom further emphasizes apolipoprotein B (apoB) and lipoprotein(a) (Lp(a)). He provides insights into risk assessment, including which lab metrics to use, how to interpret them, and the appropriate therapeutic targets. Additionally, Tom discusses the most recent developments in lipid-lowering drug therapies—from the continued evolution of PCSK9 inhibitors, to the latest understanding of EPA and DHA, and the most recent addition of bempedoic acid to the list of therapeutic agents. We discuss: The latest in the field of lipidology and cardiovascular disease [3:45]; Apolipoproteins—the key to understanding lipid biology [9:30]; ApoB as a preferred metric over LDL-P [16:30]; Therapeutic goals for apoB concentration [21:45]; Drivers of atherosclerosis [34:15]; Overview and current thinking on high density lipoproteins (HDLs)—Is it a useful metric? [37:00]; Lipoprotein(a)—the most dangerous particle you’ve never heard of [55:00]; Are low density lipoprotein triglycerides (LDL-TGs) a useful metric? [1:13:15]; Tom’s preferred lab measurements [1:17:45]; The latest in lipid-lowering therapies [1:21:30]; The different pathways among various lipid-lowering drugs [1:30:45]; The latest on EPA and DHA [1:38:15]; Fibrates—an underappreciated treatment for hypercholesterolemia [1:49:45] and; More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/tomdayspring6  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Should I Give Up Keto if it Skyrockets my LDL?, 5-2 Fasting, Avoiding weight regain after losses, LMNT/Sodium and Breast Milk Production, Low T3 Levels after long term keto adaptation Make your health an act of rebellion. Join The Healthy Rebellion Please Subscribe and Review: Apple Podcasts | RSS    Submit your questions for the podcast here   Show Notes: ---- News topic du jour: Hit or miss: the new cholesterol targets “Setting targets for ‘bad’ (LDL) cholesterol levels to ward off heart disease and death in those at risk might seem intuitive, but decades of research have failed to show any consistent benefit for this approach, reveals an analysis of the available data, published online in BMJ Evidence Based Medicine.” “Their analysis showed that over three quarters of all the trials reported no positive impact on the risk of death and nearly half reported no positive impact on risk of future cardiovascular disease. And the amount of LDL cholesterol reduction achieved didn’t correspond to the size of the resulting benefits, with even very small changes in LDL cholesterol sometimes associated with larger reductions in risk of death or cardiovascular ‘events,’ and vice versa. “Thirteen of the clinical trials met the LDL cholesterol reduction target, but only one reported a positive impact on risk of death… “Considering that dozens of [randomised controlled trials] of LDL-cholesterol reduction have failed to demonstrate a consistent benefit, we should question the validity of this theory.” “In most fields of science the existence of contradictory evidence usually leads to a paradigm shift or modification of the theory in question, but in this case the contradictory evidence has been largely ignored, simply because it doesn’t fit the prevailing paradigm.” “Moreover, consider that the Minnesota Coronary Experiment, a 4-year long RCT [randomised controlled trial] of a low-fat diet involving 9423 subjects, actually reported an increase in mortality and cardiovascular events despite a 13% reduction in total cholesterol.” https://drmalcolmkendrick.org/2020/08/05/cholesterol-lowering-has-no-impact/ 1. Should I Give Up Keto if it Skyrockets my LDL? [18:11] Charlie says: Hi Rob and Nicki, Big fan of the show. After learning about the many health and longevity benefits of keto from folks like yourself, Dr. Peter Attia, and Dom D’Agostino, I gave it a go for 4 months.  I followed a clean, dairy-free version with loads of greens and cruciferous veggies, a variety of meat and fish, avocados, olive oil, nuts and coconut, you get the idea. I confirmed ketosis regularly with a blood meter.  I felt great during the four months, and by the end even started making gains again with my kettlebells and barbell. The diet wasn’t a huge adjustment for me since I was already essentially paleo. After the four months, I got my bloodwork to compare to my baseline.  My triglycerides and HDL remained excellent, but my LDL-C skyrocketed, and my LDL-P is fairly elevated.  I am so bummed out and discouraged because I was so excited about all the longevity benefits of ketosis, but my PCP told me to go back to my previous eating habits. Here’s my question: do you have any ideas for ways I can achieve some of the benefits from ketones (BHB) while mitigating my LDL going haywire? Maybe intermittent fasting? Cyclic keto? Exogenous ketones? While the high LDL numbers scare me, I know from listening to your podcast as well as Dave Feldman that LDL isn’t the end-all be-all for cardiovascular risk. I find solace with my HDL and triglyceride levels, also my fasting glucose is very low, and my LP-IR score is below the low range, indicating I'm highly insulin sensitive. Any advice you have for me regarding my path forward with keto is greatly appreciated.  Thanks guys. For context, I’m a lean, active 34-year old male. 2. 5-2 Fasting [29:09] Devon says: Hi! I was wondering if you had any good resources, guidance, recommendations or considerations (basically anything) about 5-2 intermittent fasting. It is difficult to sift through all the crap on the internet 3. Avoiding weight regain after losses [34:29] Sarah says: Hey Robb & Nicki! I was wondering if you two could have a nice discussion about the optimal way to avoid gaining back the weight you've lost while dieting.  There's a lot of talk about the best way to lose weight, but not enough on what happens after.  I know you'd say that to lose weight, to try a low carb diet with adequate protein and electrolytes and exercise, using fat as a lever, and everything will work itself out.  However, during the pandemic, I ended up doing a VLCD, and I lost about 42 lbs from mid March to mid May.  You'd likely agree that this rapid weight loss is problematic because of lean tissue loss.  I'll tell you right now, I wasn't eating adequate protein.  The food I ate was primarily protein, but it wasn't much, some days a few meatballs...  Also I chose not to exercise during this time.  I'm sure I'm not the only one out there who gets impatient and isn't satisfied with losing .5 lbs per week even though it's the most sustainable way to lose. So anyway, I did some research (lost job because of Covid, no kids, lots of time on my hands), and I wrote it all down in a comprehensive plan to avoid gaining the weight back in the summer and moving forward.  I was wondering if you might like to consider taking a look?   And perhaps bringing some criticism/comments/tips for the the other five listeners on what we can do to stabilize after weight loss. (I'm a woman, 37, currently 208 lbs, besides obesity, all healthy biomarkers, I normally enjoy crossfit style workouts, once a week or less - not hardcore enough to build lots of muscle, and mini-triathlons in the summer) Thanks!! Notes: Conclusion: A diet consisting of high levels of animal-based protein combined with a lifestyle of  consistent strength training should go a long way to help the dieter not regain the fat mass that they have lost.  A general recommendation is to eat a diet of 35% protein, 15% carbohydrate and 55% fat.  The carbohydrate and fat can be adjusted based on how addicted a person is to certain foods, and how they see their body responding during refeeding.  An app like MyFitnessPal can calculate the percentage of macronutrients you are consuming. 4. LMNT/Sodium and Breast Milk Production [44:47] Hey Robb and Nicki! My partner Garrett and I have been huge followers of you since the beginning of our relationship, 11 years ago! We just welcomed our second daughter about two months ago. I'm exclusively breastfeeding and I've noticed an increase in milk supply while drinking LMNT. Is it safe to drink it more than once a day or is that not recommended? Thanks, Margo 5. Low T3 Levels after long term keto adaptation [49:24] Diva says: Hello Rob and Nikki, First of all, thank you so much for the wonderful work that you two do! I would like to know what are your thoughts on low T3 levels after long term Keto adaptations. According to Phinney's work, amongst other evidences, it seems that it is physiological normal for Keto adapted people to no longer require high free T3 levels, according to standard recommendations. I am a 44 year old athlete. I have been Keto adapted for over 12 years. I was diagnosed with hashimoto hypothyroidism 25 years ago. My antibodies have been under control since after starting a Keto Paleo lifestyle and I've able to reduce my T4 dose considerably as well. However, my free T3 levels are very low, below the standard recommendations of 2.0 I am COMPLETELY asymptomatic though. My body composition is great, I'm very muscular and carry 9% body fat effortlessly throughout the years. Despite knowing about the T3 efficiency that Keto adapted people acquire, about two years ago I decided to experiment with adding exogenous T3 to my T4 dose. I noticed no difference on energy levels but I did notice that I started losing muscle mass! Which makes sense because one of the reasons that T3 may be lower on Keto is due to muscle sparring. I stopped taking T3 about one year ago and have gone back to T4 only since then. But one trend that I noticed is that my fasting insulin has increased a little. Nothing much. It used to be around 3 and now its 5.3. This started happening after I added T3 to the mix. I have since stopped taking T3 but my insulin has not gone back to levels that it used to be before taking it. I know that artificially raising T3 levels may raise insulin but shouldn't it have gone back down after stopping the med? I wear a CGM and my blood sugar control is stellar! I can handle carbs very well, I've been testing with that, and even after eating tons of carbs, like 200g at one seating, my blood sugar didn't move past 13 points. The maximum increase was 105. And I'm not kicked out of ketosis. Other than that my average blood glucose is about 85. The only times that it goes up is after high intensity exercise, then it goes above 150, 170 sometimes! But I know that this is physiologically normal so it doesn't concern me. My question is: what are your thoughts on the T3 efficiency after being Keto for so long? Should we try to artificially push up FT3 levels despite having no symptoms? And should I worry about a fasting insulin of 5.3 despite obviously being super insulin sensitive?? Thank you so much for your insights to this matter! Diva.   Sponsor: This episode of The Healthy Rebellion Radio is sponsored by our friends at Paleovalley. They make “Nature’s Multivitamin” composed of nutrient-dense organ meats that contain the vitamins and minerals we need for all-day energy, supported mental health, and overall vitality. Plus, they’re all-natural. Nothing weird. Just food. Check them out at www.paleovalley.com/thrr and use code THRR10 for 10% off.   

Back by very popular demand for a special AMA episode, ketosis expert Dom D’Agostino joins Bob Kaplan, Peter’s Head of Research, to address many lingering questions about the ketogenic diet, exogenous ketones, and exercise for overall health. Dom also shares valuable insights from his personal experience with training, supplements, intermittent fasting, and other nutritional strategies to optimize his own health and performance. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA.  If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on the website show notes page. We discuss: Dom’s recent and ongoing projects [3:00]; Benefits of a ketogenic diet for an otherwise healthy person [7:00]; Book recommendations to become more knowledgeable about a ketogenic diet [11:30]; Best devices for measuring ketones [13:45]; Genetic factors that influence how someone responds to the ketogenic diet [24:45]; Ketogenic diet for those with the APOE e4 allele [28:15]; Impact of long-term ketogenic diets on thyroid function [34:25]; Low-carb and ketogenic diets for appetite control and weight management [39:00]; Ketogenic diet and the microbiome [43:00]; Comparing monounsaturated fat versus saturated fat on the ketogenic diet [45:55]; Implications of long-term genetic and epigenetic adaptations to a ketogenic diet [47:45]; Why some people see a rise in LDL-C and LDL-P when on a ketogenic diet and what they can do about it [50:15]; Should someone with familial hypercholesterolemia consider a ketogenic diet? [55:00]; Exogenous ketones—benefits, therapeutic uses, and ketone supplements that Dom has tested [56:45]; Ketogenic protocols for management of traumatic brain injuries [1:06:00]; Comparing the benefits and therapeutic uses of various medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45]; Nootropics, caffeine, and other stimulants [1:16:15]; Supplemental use of testosterone, DHEA, and creatine for muscle growth and performance [1:23:45]; Impact of fasted-state training on strength and performance [1:30:15]; Stacking exogenous ketones with MCTs for optimal effectiveness [1:33:30]; BCAA supplements during a fast for muscle preservation [1:35:45]; What app is Dom using to track his macros? [1:42:00]; Getting enough micronutrients while on a ketogenic diet [1:47:15]; Ideal macros and getting enough protein for strength training in ketosis [1:48:15]; Pros, cons, and ideal macros of one meal a day [1:51:15]; Dom’s take on “carb backloading” [1:54:45]; Dom’s take on “carb up” days for ketogenic dieters [2:01:00]; Dom’s thoughts on the carnivore diet and the paleolithic ketogenic diet [2:05:30]; Advantages of the ketogenic diet for extreme endurance athletes [2:10:30]; Impact on strength, power, and performance during the adaptation period of the ketogenic diet [2:14:00]; Fasted-state elevation in growth hormone and its impact on training [2:17:45]; Is it possible to build muscle on a ketogenic diet? [2:23:30]; Why Dom took a year off from weight training [2:28:00]; What does Dom do for cardio exercise? [2:30:45]; Protocols for hard training recovery [2:33:15]; Dom’s personal approach to fasting, time-restricted eating, and sleep [2:35:45]; People, books, and other resources that shaped Dom’s training and nutrition [2:38:45]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/domdagostinoama01 Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Podcast Notes A ketogenic diet stimulates metabolic flexibility and functions similarly to muscle memory: the more you do it, the more your body will rememberThe target of a restricted ketogenic diet is to achieve glucose-ketone index between 1 and 2Biosense breathe acetone meter is the ketone measurement device of choice for Dom if he can’t measure bloodeval(ez_write_tag([[728,90],'podcastnotes_org-medrectangle-3','ezslot_0',122,'0','0']));Read the full notes @ podcastnotes.orgBack by very popular demand for a special AMA episode, ketosis expert Dom D’Agostino joins Bob Kaplan, Peter’s Head of Research, to address many lingering questions about the ketogenic diet, exogenous ketones, and exercise for overall health. Dom also shares valuable insights from his personal experience with training, supplements, intermittent fasting, and other nutritional strategies to optimize his own health and performance. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA.  If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on the website show notes page. We discuss: Dom’s recent and ongoing projects [3:00]; Benefits of a ketogenic diet for an otherwise healthy person [7:00]; Book recommendations to become more knowledgeable about a ketogenic diet [11:30]; Best devices for measuring ketones [13:45]; Genetic factors that influence how someone responds to the ketogenic diet [24:45]; Ketogenic diet for those with the APOE e4 allele [28:15]; Impact of long-term ketogenic diets on thyroid function [34:25]; Low-carb and ketogenic diets for appetite control and weight management [39:00]; Ketogenic diet and the microbiome [43:00]; Comparing monounsaturated fat versus saturated fat on the ketogenic diet [45:55]; Implications of long-term genetic and epigenetic adaptations to a ketogenic diet [47:45]; Why some people see a rise in LDL-C and LDL-P when on a ketogenic diet and what they can do about it [50:15]; Should someone with familial hypercholesterolemia consider a ketogenic diet? [55:00]; Exogenous ketones—benefits, therapeutic uses, and ketone supplements that Dom has tested [56:45]; Ketogenic protocols for management of traumatic brain injuries [1:06:00]; Comparing the benefits and therapeutic uses of various medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45]; Nootropics, caffeine, and other stimulants [1:16:15]; Supplemental use of testosterone, DHEA, and creatine for muscle growth and performance [1:23:45]; Impact of fasted-state training on strength and performance [1:30:15]; Stacking exogenous ketones with MCTs for optimal effectiveness [1:33:30]; BCAA supplements during a fast for muscle preservation [1:35:45]; What app is Dom using to track his macros? [1:42:00]; Getting enough micronutrients while on a ketogenic diet [1:47:15]; Ideal macros and getting enough protein for strength training in ketosis [1:48:15]; Pros, cons, and ideal macros of one meal a day [1:51:15]; Dom’s take on “carb backloading” [1:54:45]; Dom’s take on “carb up” days for ketogenic dieters [2:01:00]; Dom’s thoughts on the carnivore diet and the paleolithic ketogenic diet [2:05:30]; Advantages of the ketogenic diet for extreme endurance athletes [2:10:30]; Impact on strength, power, and performance during the adaptation period of the ketogenic diet [2:14:00]; Fasted-state elevation in growth hormone and its impact on training [2:17:45]; Is it possible to build muscle on a ketogenic diet? [2:23:30]; Why Dom took a year off from weight training [2:28:00]; What does Dom do for cardio exercise? [2:30:45]; Protocols for hard training recovery [2:33:15]; Dom’s personal approach to fasting, time-restricted eating, and sleep [2:35:45]; People, books, and other resources that shaped Dom’s training and nutrition [2:38:45]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/domdagostinoama01 Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

For full show notes, transcript, link to video, and more visit the show's blog at: https://robbwolf.com/2020/03/13/coronavirus-anticoagulants-diarrheaonketo-thrr020/ This episode is sponsored by Joovv. Joovv is the leading manufacturer of personal, in-home red light therapy devices, with several different sizes and setups. Clinical grade power to help reduce pain, fight inflammation, so you can live a happy healthier life. Check them out at joovv.com/robb and use code ROBB for a free gift with your purchase. Download a copy of the transcript here (PDF) (coming very soon) Watch the podcast video here Submit your questions for the podcast here Show Notes: News topic du jour: Corona Virus Video from SARS expert Dr. Hui- http://news.tvb.com/programmes/straighttalk/5e6799f9335d19df678ed10f/--Will-the-coronavirus-burn-out-or-become-a-pandemic -No innate immunity -Medical systems CAN get over run -That would increase the morbidity/mortality -It IS technically a pandemic -A vaccine is 12-18 months away at the earliest Framework for thinking through COVID19 https://theprepared.com/blog/pandemic-scenario-guide-a-framework-for-thinking-through-whats-next-for-covid-19/ Eli Pariser: 8 days of US vs Italy COVID mapping: https://twitter.com/elipariser/status/1237840413857202178?s=20 Thomas Pueyo: Coronavirus-Why you must act now https://medium.com/@tomaspueyo/coronavirus-act-today-or-people-will-die-f4d3d9cd99ca -Containment and social distancing works, but the cats outa the bag in much of the world -If medical systems get overwhelmed, it can be bad Peak Prosperity Crash course: Exponential growth https://www.peakprosperity.com/video/crash-course-chapter-3-exponential-growth-3/   1.  How To Offset Effects of Long-term Anticoagulant Use? [20:52] Micah says: Hi Robb, absolutely love your podcast and have a question I was hoping you could help me with. I have been hearing a lot about vitamin K2 and how it helps move calcium out of the arteries and into the bone. My issue is I am on warfarin for life due to multiple blood clots over the past few years and I worry about the long term affects. My doctors believe the clots are due to my ulcerative colitis which is now under control thanks to the GAPS protocol and now a mostly paleo diet. They are still unwilling to take me off the blood thinners. My question is is there anything I can do to offset the effects of long-term anticoagulant use in my arteries and bones. I am a 31-year-old male and healthy with the exception of the issues I’ve mentioned above. I weight lift 4 to 5 times a week in a bodybuilding type style. Long-term warfarin therapy and biomarkers for osteoporosis and atherosclerosis-2015 Reduced bone density in patients on long-term warfarin. 2009 2. Diarrhea on Keto? [25:43] Gaju the KetoPooper says: Hi Robb, Dig your content. You were responsible for turning me on to paleo. I've been doing keto for close to a year now. However, whenever the fat content in my meal goes up and there's some fiber present from vegetables, diarrhea occurs soon after. Unless my physiology is abnormal, I expected my body to be able to process the fat by now. Reducing the veggies or the fat that I add to my meals in the form of olive oil, duck fat, avocado oil and so on, seems to keep the diarrhea in check. But the calories consumed go down substantially. As an active person looking to make significant strength gains in the gym, this bums me out. Right now, I'm trying to see if the magnesium in the electrolytes I consume (Lyteshow) might be the culprit. But any leads you can provide would be very helpful. 3. How To Make Paleo/Atheist Friends? [29:49] Karen says: Hi, I have been eating a paleo derived diet since 2011. When I read your book and lost 45lbs in 4 months and I have kept it off since. Recently I have had 2 children and I feel like it’s difficult to live this lifestyle in the OC, Ca area with children. Also my husband and I are atheists (my dad is a Scientologist). I don’t know if you’ve answered this before, but I am curious how I am supposed to meet like minded people with a similar diet in the area. We already belong to a CrossFit gym and they are predominately unhealthy eaters and religious. Maybe I should just join a different one or find a meetup group? Thanks, Karen 4. The Croissant Diet: Is There Something Here? [36:43] Tyler says: Hey Robb and Nicki, I've been a shown listener for several years now, and I always enjoy y'all's (yes I'm from Texas) perspective on a variety of health topics because it's unique and usually gets me thinking. So, Mark Sisson posted a blog post recently from a guy who did a so called "Croissant Diet" for weight loss, which really boils down to maintaining a certain ratio of saturated:unsaturated fat intake and a few other things which he claims can alter metabolism favorably in terms of weight loss. He also asserts that it is an ancestral diet, aka the French, though really a rather recent one. My question is this - is he on to something? Is there any substance or lessons that could be learned from him? Sounds like it was really satiating which probably helped drive the weight loss. And if he is on to something, how could someone apply it - and especially those of us in whom high saturated fat intake seems to equal sky-high LDL-P levels. Thanks for all y'all's work, it's much appreciated and needed. Tyler https://fireinabottle.net/introducing-the-croissant-diet/ 5. Salt Sensitivity? [47:24] Laura says: Question: I've run my DNA through a variety of tools (strategene, DNA fit, Found My Fitness, Nutritional Genome and most recently a Viome Gut Biome test).   All point to me being very salt sensitive.    Being that I'm very low carb and salt sensitive - what sort of guidance would you give to be sure I get the right level of salt in my diet? I am a LMNT subscriber and originally was putting a full packet in my water throughout the day (micro dosing) - then stopped when I noticed some tremendous swelling (ankles disappeared and I took my ring off).  Recently I've tried adding some smaller doses back in - but I'm nervous around pushing that too much with my salt sensitivity. Stats: 45 yo female 5'8" 157lbs / 18% body fat Movement: historically: kettlebells (45mins MWF); Jog (30mins TTh), hiking or the like (1hr+ SSun) currently:  Core40 (pilates based movement with more a heavy resistant / slow movement focus - 40mins MWF); walk (30mins TTh) Diet: keto / carnivore for about 3 years.   Currently doing OMAD (one meal a day) for ease and feels more intuitive for me.    Currently doing a bit of a cut cycle and adding in a Protein Sparing Modified Diet to lean out / reset after some vacay fun.  After this I will go back to more of a Keto OMAD style. Health history: Used paleo and functional medicine to overcome SIBO in the last 3 years and then transitioned to keto / carnivore recently seeing that I don't digest greens well often.  Have had great success with lower carb (feeling, clarity etc) but am starting to see what may be some overstressed symptoms (fatigue, ear ache / issues typically come up for me). I still have on my list to do a  proper carb test per Wired to Eat.... I hope that gives enough of a background for my question :) What are your thoughts? Laura

Your DNA alone is worthless. So claim my guests on today's show, Dr. Matt Dawson and Dr. Mike Mallin of , with locations in Versailles, KY, and Bend, OR. I first interviewed these guys in the episode "" and now they're back to talk all things DNA and genetics. Dr. Matt Dawson is a precision medicine physician in Lexington, KY, co-host of the and has been obsessed with performance optimization as long as he can remember. He received scholarships to play two sports in college even with “minimal talent” because of his voracious reading and implementation of any fitness or nutritional techniques that would give him an edge. Dr. Dawson continued that obsession in medical school and, as a physician, he has won national awards for education, innovation, and leadership. He has lectured in over 20 countries and trained thousands of other physicians through live lecture, online education, two textbooks, and an educational app. Dr. Dawson combines his training in genomics and functional medicine to give personalized, precise medical guidance. His obsession with performance optimization has morphed from initially athletic to now mental performance and longevity. Whether it's a professional athlete or a grandparent optimizing their mental clarity and mobility to keep up with their grandkids, Dr. Dawson is passionate about helping everyone perform at their absolute peak. Dr. Mike Mallin is a physician in Bend, OR who is obsessed with health performance and precision medicine and is co-founder of the . He completed medical school in South Carolina and trained in Emergency Medicine in Salt Lake City, UT where he competed in several ultramarathons and found his love for the mountains and performance. Mike currently practices in Bend, OR and Lexington, KY in his precision medicine clinics. He is also co-founder of the , an educational podcast that has taught thousands of physicians all over the world how to use ultrasound, as well as , his podcast focusing on health performance and longevity. During our discussion, you'll discover: -Why DNA data in and of itself is insufficient... Epigenomics: Genomics taken in context of the whole person Get a sense of what a person's genes are transcribing via lab values Understand how lifestyle and habits can affect specific genes (ex. PGC1A) Needed a simplified means of interpreting genetic results Falsehoods have been noted in DNA reports A comprehensive analysis includes lifestyle, preferences, microbiome, etc. DNA reports will occasionally translate RSID's wrong Misreading data can lead to unhealthy lifestyle decisions -What sets Drs. Dawson and Mallin's new software apart from other DNA software... Lifestyle and patient preferences factor heavily Microbiome data is important Looking for a more comprehensive picture of a patient than simple data Cholesterol levels, cardiovascular conditions, etc. are taken into account -The results from the software thus far... "Whole picture" approach allows for more accurate diagnoses and appropriate recommendations Cardiovascular risk down  by over 50% in less than 6 months on average LP(a) decreases more than 2 years of statin treatment LDL-P down an average of 357 points per patient CRP down over 50% in patients who start off with it elevated Average HRV increase of 15 from genomic based training programs All mostly without pharmaceuticals -How Matt and Mike test for aging, and their "gold standard" longevity protocol... Get the basics right first: sleep, environment, exercise, sunlight, etc. Personalized: genomics, preference based Get biological age first: True Age Test DNA Age Test Horvath Clock tests methylation in the body; telomere test results have been erratic Pulse press cycle is important MOTS-C Article: Use peptides w/ caution; opt for natural treatments first Exercise protocols used during anabolic phase of treatment and endurance Short interval Longevity exercise programs Fasting, , Dr. John Douillard's Dr. Valter Longo's -NAD protocols used by Mike and Matt and Ben... A lot depends on patient preference RG3 nasal spray -Peptides used in the Wild Health practice... Semax for neuro-cognitive  strength Selank for anxiety Dihexa for neural optimization CJC-1295 Ipamorelin Epithalon GHK Zinc Thymulin Tailor Made triple (zinc, copper and minoxidil) and for injury recovery -Goings on at the Kentucky Castle... , float tank, cryotherapy, sauna on site Food and farming on site Organic garden Sheep and goats Chickens April 7-9 conference Ben will be speaking Teach how to apply what's been discussed in this episode Open to the public, but focused on physicians and practitioners -How Mike and Matt practice what they preach on an individual level... Matt: Intermittent fasting (work out later for bigger fasting window) therapy (turned all the way up, , ) are an ideal food; greens, Put an egg w/ and in Mike: Sprint Interval Training (SIT) CGM () Roast at home   -And much more... Resources from this episode: - website - - - - - - - - - - Episode sponsors: -: My personal playground for new supplement formulations, Kion blends ancestral wisdom with modern science. Ben Greenfield Fitness listeners, receive a 10% discount off your entire order when you use discount code: BGF10. -: A plant-based beverage that helps support the body’s natural ability to produce collagen, smooth fine lines and wrinkles, and protect the skin from sun exposure and toxins. Receive a 20% discount on your entire order when you use discount code: "BENG20" -: A wellness company specializing in innovative nutraceuticals made from healing hive compounds and plant-based ingredients. Get 15% off your order when you use discount code: BEN -: Activewear and athletic clothing for ultimate performance. Vuori is built to move and sweat in, yet designed with a West Coast aesthetic that transitions effortlessly into everyday life. Receive 25% off your first order when you use discount code: “BENG25" Do you have questions, thoughts or feedback for Dr. Dawson, Dr. Mallin or me? Leave your comments below and one of us will reply!

Question: "If cholesterol, LDL-P, and oxidized LDL are high, the sterol panel is normal, and TGs are great, would you suspect clearance of the particles driven by LDL receptor in the liver is the issue, and what would you recommend to boost LDL-R?"   Yes, it sounds like you should target LDL-R.    The big regulators of LDL-R function are thyroid hormone, and the amount of cholesterol in the liver cell, and anything that brings bile acids into the feces, and that's generally a high-fiber diet; psyllium husk would be a fiber you could add.   Thyroid hormone is the other piece of that, and that you target with higher carbohydrate intake. Higher carbohydrate intake also acts on PCSK9 to boost LDL receptor activity.    This Q&A can also be found as part of a much longer episode, here:https://chrismasterjohnphd.com/podcast/2019/02/09/ask-anything-nutrition-feb-1-2019/    If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.  He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks. He’s since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. Where he induced a 73 point drop in my LDL-C and a 1115 point drop in my LDL-P.  Siobhan (she'-VAUN) Huggins is an independent researcher focused on lipidology, the immune system, and metabolic diseases. She spends most of her time at cholesterolcode.com where she works alongside Dave Feldman. She has been keto since August of 2016, and on a predominantly carnivorous diet as of October 2017. She has lost 80 lbs, reversed hypertension, and found a passion for research along the way. 5:47 Dave Feldman's blood testing at low carb San Diego 7:17 The Feldman Protocol 9:39 Does it matter whether subjects are a ketogenic vs. carbohydrate based metabolism 11:19 What labs were administered? 13:03 Shevawn(Siobhan??) on the inflammatory markers. 14:09 What's the sense of the half-life of HSCRP? 18:09 Ferritin 22:34 Other Markers being tested? 25:29 Glucagon 27:17 is it expected from these labs to find free fatty acids in the blood ? 29:23 What do you use as a cutoff for high fasting insulin? 30:00: C-Peptide 32:55 Hemaglobin A1C 34:37 Test frequency/pitfalls of looking at tests in isolation. 38:09 The Lipid Panel ,(triglycerides) 42:42 How are Triglycerides different from free fatty acids? 45:22 Measuring Triglycerides. What Happens to triglycerides after eating a high fat Carnivore meal? 50:13 Any utility to non-fasted lipid panels ? 50:52 Will triglycerides be higher on a Ketogenic diet (postprandially) 51:39 difference in postprandial triglycerides between Keto and carbohydrate based metabolisms.  54:14 Recommendations around Triglycerides. 58:32 What else elevates triglycerides? 1:01:39 Thoughts on Coffee 1:04:56 National Health and Nutritional Survey. 1:06:49 How many people are in this data set? 1:08:15 What is linear regression? 1:11:58 Why Dave wanted to look at all cause mortality. 1:13:52 Ldl and all cause mortality  1:14:57 Age parity  1:16:37 "The Dave Dance" 1:17:52 Critique:diseases that bring down LDL. 1:20:59 What epidemiology is useful for. 123:32 What happened when those who died within 10 years. 1:23:22 How many people ended up in the age parity subset? 1:25:20 How could LDL be good for you? 1:31:57 Evolutionary role of insulin resistance. 1:32:14 Insulin Resistance and infections. 1:36:37 Underlying Triggers 1:37:10 Virta program. 1:39:52 Carnivore Diet talk. 1:42:22 Studies on Antioxidants. 1:45:17 Lp(a) 1:50:07 Can you change Lp (a) 1:59:47 What characters would Dave and SIobhan be at Comic Con ? 2:00:42 The most radical thing they did recently  Dave’s contact information:   www.cholesterolcode.com  Twitter: @daveketo Instagram: @davefeldmanketo   Siobhan’s contact:   Twitter: @siobhan_huggins Website: cholesterolcode.com      Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   JOOVV: www.joovv.com/paul   INSIDER: carnivoremd.com   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram: @carnivoremd Website: carnivoremd.com Twitter:@carnivoremd  Facebook: Paul Saladino MD email: paulsaladinomd@gmail.com   Be sure to subscribe for more medicine and lifestyle content. Stay radical!  

The brilliant and articulate Paul Saladino MD - what a great discussion - see index below! For full TRANSCRIPT: https://thefatemperor.com/2958-2/ VIDEO PODCAST: https://www.youtube.com/watch?v=MqofVmSlj1A 00:00:51 Plant-Based good, Carnivore bad – it seems to most doctors 00:04:41 The baddest foods on the planet 00:08:04 Paleoanthropology – and how our bodies function best 00:12:48 The Vitamin C Conundrum - explained 00:18:00 Niacin and B Vitamins – what's the real deal? 00:20:24 What about the QUALITY of the meat you eat? 00:25:01 Global Warming – where is meat seated in the controversy? 00:29:54 The wisdom of our ancestors 00:32:34 Cholesterol and particle numbers – LDLp and ApoB – is the risk rational? 00:41:17 CAC and really getting to the bottom of things 00:45:59 Thomas Dayspring & the credibility of ApoBB Bullets shooting up your arteries 00:52:40 CAC and the “focal nature of atherosclerosis” 00:54:42 Watch dietary changes on blood markers – but don't discount carnivore benefits 00:56:49 Mikhaila Peterson, and the power of elimination in these diets 01:00:02 Plants can't run away – but they do have Lectin Defences 01:03:42 Beans, brains and autoimmune neurological disorders 01:08:05 Rhonda Patrick and the benefits of sulforaphane – or not?? 01:11:20 Tucker Goodrich, 4-HNE, seed oils – and the value of plants? 01:14:37 The fiber thing, the Plant Paradox and Dr. Steven Gundry. 01:17:45 Methionine and Glycine balance – and aging mice – what gives? 01:21:15 ApoE4, cheese and tallow – a complex equation 01:25:22 Lipopolysaccharides, plants and autoimmune maladies 01:29:00 A challenge - show me a disease that is not autoimmune that is chronic 01:29:45 The least toxic plant foods – listed in fairness

Despite a shifting scientific landscape, dietary cholesterol is still a hotly debated topic. Joe Rogan and Chris Kresser eat eggs every day, while the plant-based community still loves to highlight the supposed dangers of dietary cholesterol. High cholesterol has historically been associated with poor health, but is there a range where cholesterol levels get too low? Our guest in this episode of the podcast believes the combination of a genetic predisposition combined with a strict vegan diet caused him to develop a dangerous cholesterol deficiency. A former assistant professor of Nutrition Science at Brooklyn College, Chris Masterjohn, Ph.D. is one of the smartest minds in nutrition. Chris shares a fascinating story of how going vegan caused him to develop nutrient deficiencies which led to a battle with mental illness and anxiety. Chris' subsequent focus on nutrient-dense, animal-based foods restored his health and changed his perspective on how the foods we eat play a large role in cognitive function. We cover a wide range of topics with Chris and he takes a number of controversial positions in this episode, including who shouldn't eat eggs, nutrient deficiencies that are most likely to arise on a carnivore diet, whether “fancy” blood testing metrics like LDL-P are necessary to gauge cardiovascular health, why some people fail on vegan diets and much more.

PODCAST Ep26 - Full version of conversation with super well-researched Australian doctor Paul Mason @DrPaulMason - recorded in Boulder, Colorado. We covered: LDL-P, ApoB, Lipoprotein(a) / Lp(a), Oxidized LDL, Omega 6 Seed Oils, Gilbert's Syndrome, Antioxidants, Bilirubin, Glutathione, Carnitine versus Carnosine, Wheat Germ Agglutanin, GGT, CIMT, CAC, Glycation, Lectins, FODMAP, Magnesium, Selenium, CGM Continuous Glucose Monitors, Parkinson's Disease, and more! YOUTUBE VIDEO PODCAST HERE: https://youtu.be/pKtRa3JG-Gg TRANSCRIPT: https://thefatemperor.com/wp-content/uploads/2019/06/Dr.-Paul-Mason-Advanced-Cholesterol-Chat-and-Much-Much-More.pdf INDEX: 00:00:23 Some insights on the new cholesterol risk factor – Lipoprotein(a) or Lp(a) 00:05:10 Discussion of the role which Oxidised LDL or oxLDL has in heart disease 00:08:32 Glycation damage to LDL – a crucial part of the heart disease problem? 00:09:52 Omega 6 vegetable or seed oils add to the inflammatory cascade of destruction 00:11:17 Oxidized LDL receptors and their place in the system 00:12:33 Gilbert's Syndrome, Bilirubin and greatly reduced heart attack rates 00:14:50 Glycation, Antioxidants – Carnitine and Carnosine Distinction 00:18:27 The body's master antioxidant – Glutathione – and the Importance of GGT 00:22:08 Medical school training in nutrition – sadly lacking for doctors? 00:24:23 LDL-P, ApoB100, LDL Receptor activity – the bottom lines 00:29:24 Coronary Artery Calcification (CAC) versus Intimal Media Thickness (CIMT) 00:36:08 HbA1c and Fructosamine as risk factors 00:39:26 Continuous Glucose Monitors (CGM) and blood glucose fluctuations 00:42:05 Insulin measurements, HOMA IR and post-prandial spikes 00:45:58 CGM and problematic medications – rather fix root cause? 00:50:16 Let's look at Lectins – the taxing toxins from plant world foods 00:56:21 Parkinson's Disease and the Lectin Connection 00:59:46 Dr. Steven Gundry, poisonous beans, more lectins and the toxic ricin 01:04:27 FODMAP foods, GMO fun, WGA from wheats, lots of bad actors 01:08:07 Nuts! (and Magnesium, Selenium etc.) 01:11:20 Moving forward and emphasizing the core – Pareto-style

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all a better off for it.   He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.   He’s since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data (see his Cholesterol Code series Part I, Part II, Part III, Part IV, and Part V). As of this writing, his “Extreme Drop” experiment has gotten the most attention (see infographic here, and do-it-yourself page here) where he induced a 73 point drop in my LDL-C and a 1115 point drop in my LDL-P.   In this show we discuss Dave’s recent talk at Keto Salt Lake which can be found on YouTube here: https://www.youtube.com/watch?v=UZv00mMiB9M   Dave’s contact information:   Www.cholesterolcode.com Twitter: @daveketo Instagram: @davefeldmanketo     Don’t forget to support Ancestral Supplements https://ancestralsupplements.com/   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA Instagram: https://www.instagram.com/paulsaladinomd Website: paulsaladinomd.com Twitter:@mdsaladino Facebook: Paul Saladino MD email: paulsaladinomd@gmail.com   Be sure to subscribe for more medicine and lifestyle content. Stay radical!  

We're at it with another Q&A podcast, Episode 423! If you want to see the video for this podcast, be sure to check out our YouTube channel.   Show Notes   1. [1:31] Aced the 7 day challenge like your wife! So why am I doing this??? Erica says: Hello, I LOVED your book Wired to Eat. I'm a 31 year old female. 6ft, at my goal of 160ish lb, 20% body fat. Ive never been heavy, don’t have diabetes in my family. I do have a history of disordered eating - counting/restricting calories and then binge eating until a year ago when I found low carb. I’ve been on thyroid meds for a few months now, possibly because of the calorie restriction. I’ve had high cholesterol all my life and now it’s even higher since starting Keto 2 months ago (total from 274 to 336! HDL ratio went from 3.2 to 4.7!  Triglycerides now 106 (non-fasting), havent had my A1C checked for awhile but it was 5.3 long before keto. going to have my LDLp and fructosamine checked soon.) Low carb/intermittent fasting has reallly helped me maintain my weight while avoiding trigger foods. I went full Keto 2 months ago because the hunger control intrigued me. It’s gotten MUCH more tolerable, but I still get hunger pangs for breakfast and afternoon snacks daily. But for the first time in my life my very hormonal acne cleared up from keto! Now, I took the test after 2 months keto and aced it! Every day of the challenge my glucose was similar to your wife's, even the day I ate a doughnut! So my question is... why am I doing this whole low carb thing? I guess no pimples and no trigger foods is a good enough reason; but my question is, are bad carbs even that bad in my case? Maybe my insulin response is a different picture, as my weight seems to come back easily with carbs? But it sure makes resisting cravings difficult now that I know my glucose response will be fine if I have that doughnut and I'll go back to my usual mild ketosis within a few hours if I can manage not to eat again soon after. Any tips? Has your wife changed how she eats now that she knows her blood glucose will be fine with most anything she eats? Thank you so much for your response!   2. [10:10] Beer and blood sugar Thom says: Robb and Nicki: Thank you both so much for the work you do to educate the Paleo/Keto community. I have been Paleo for nearly 6 years now and Keto for 2, due to a suggestion given me after having a colectomy and still not feeling good. The results I've experienced are nothing short of miraculous. That has led me to become a huge advocate for the lifestyle and to share it with anyone who will listen. I do heating and air conditioning service, which affords me the opportunity to share it with many people. My question is this: You have mentioned many times that we should do as many N=1 experiments to see what works for us individually. I have been keeping tabs on my blood sugars, blood pressure, O2 and heart rate levels as well as several clinical blood tests (I don't visit the doctor very often, since all they want to do is shove drugs in me every time I go in). Over the years I've been able to hone in on the majority of foods or lifestyles that make me feel good and the ones that make me feel not-so-good. That said, I wanted to pose a question to you. I have done this test over and over and am very shocked by the results. If I have a typical dinner with a salad or veggies of some sort and some meat, then pair that with low carb wine or tequila, lime and soda water (both very low carb drinks), my blood sugars will be somewhere between 130 and 180 two hours later. However, if I have beer (typically dark, because I prefer the porters and stouts) and check my blood sugars two hours later, I'm usually below 100 and sometimes as low as 80 or 78. I have tested these variables over and over throughout this past year (yes, I like my drink) and I get the same results. However, I HAVE noticed that the lighter beers, such as ales or lighter IPA's do not keep my blood sugars quite as low. Do you know of anything that might explain this phenomenon? I have many more questions I would like to ask you, but I'll leave it at this one for now. Again, thank you both for all you have done and are doing to keep this community going. My son keeps telling me that I should start my own blog and podcast to help spread the word about this lifestyle. When he does I always mention that I have no definable credentials, such as yours, so I'm not convinced anyone would even listen to it. So, instead I point him, and many others, to your podcast and website, along with Jimmy's, Chris's and Mark's. You're all very educational and the cornerstones of this community. Keep up the good work. ThomE   3. [15:28] High morning glucose on LCHF diet (95 mg/dl) Gregor says: Hi Robb, I really appreciate what you are doing and I am a great fan of your podcasts (I read transcripts). Anyway, to the point: after I cut off grains, sugar, legumes and so on, my fasting glucose went high. On average it is 95 mg/dl, mostly between 90 and 100 mg/dl. You mentioned this subject in your 385th podcast with Shawn Baker (one of my favorites podcasts on your site), but I didn't feel it was fully addressed and explained. I have a graph for about 15 years of measurements here: https://paleosmak.pl/wp-content/uploads/2018/08/glukoza-paleo-2018.png - around 2010 I turned paleo/lchf. Recently I have measured my fasting insulin level and it was 4,9 µIU/ml. I have also measured my glucose levels for one typical day and it is very stable, between 90 and 109 - here is the graph: https://paleosmak.pl/wp-content/uploads/2018/10/dobowy-profil-glikemii-paleo-smak.png (the orange vertical lines are meals, I eat only twice a day). I know I am no diabetic. I have no health issues except 2-3 mild autoimmune diseases (the symptoms come and go). Is my quite high fasting glucose anything to worry about? I have a friend following quite similar diet and life style and his fasting sugar is around 70-75. Does my 95 mg/dl fasting sugar have negative impact on my health, aging speed and so on? Can I do anything about that? Thanks so much for talking one more time about that. Gregor https://optimisingnutrition.com/2019/04/02/how-much-salt-do-you-need/ https://www.drinklmnt.com/the-science   4. [20:12] paleo approach to skin care Andrea says: Robb, do you have any advice about skin care, such as use of any daily moisturizer or other products? I don't use daily sunscreen because I tend to have low Vitamin D levels, but I use it if I'm going to be outside for an extended period of time. I am approaching 40 and only use a bit of jojoba oil as a moisturizer. I wash my face with bar soap (not the antibacterial kind). I'm not sure if my minimalist approach is the way to go. Maybe your wife has some experience with some products for women? Thanks! Anne marie skin care Feather eagle sky beauty face oil ***Organic Rose Hip Seed oil, Sweet Almond oil, Argan oil sunscreen 5. [25:51] Weight loss and fat tissue toxin-release Jarno says: Hi Robb, Greetings from Finland! I love your work, thank you for everything you do! I really liked your stance on the carnivore diet as you discussed it with Mikhayla Peterson. Let's not become vegan zealots about it. I've been eating 70-80% carnivore for 6 months and feeling mostly great. Mostly because it's not all great. Which brings me to my question. What is your sentiment about the toxin-release from fat tissue during weight loss thingy? Is it real? What the science says at the moment? Have you heard of any connections with joint pain / arthritic pain or nausea with weight loss induced toxin release? I'd love to hear your thoughts about this! Best regards, Jarno     Where you can find us: YouTube Facebook Submit questions: https://robbwolf.com/contact/submit-a-question-for-the-podcast/

Chemical engineer Ivor Cummins is our interview guest today in Episode 1462 of “The Livin’ La Vida Low-Carb Show.” Ivor Cummins BE(Chem) CEng MIEI completed a Biochemical Engineering degree in 1990. He has since spent over 25 years in corporate technical leadership and management positions and was shortlisted in 2015 as one of the top 6 of 500 applicants for “Irish Chartered Engineer of the Year”. Ivor’s career specialty has been leading large worldwide teams in complex problem-solving activity. Since 2012 Ivor has been intensively researching the root causes of modern chronic disease. A particular focus has been on cardiovascular disease, diabetes, and obesity. He increasingly shares his research through public speaking engagements at various health conferences around the world. Most recently he presented at the Irish National Institute of Preventative Cardiology (NIPC) conference – and went on to defend low carb in an hour-long debate (against four professors of medicine/nutrition!). Ivor’s recently published book “Eat Rich, Live Long” (co-authored with preventative medicine expert Jeffry Gerber MD, FAAFP), details the conclusions of their shared research. It comprehensively addresses the actions needed to reverse our modern disease epidemics. All of Ivor’s public lectures and interviews are available on his YouTube channel, where around 2 million views have been recorded to date:  https://www.youtube.com/channel/UCPn4FsiQP15nudug9FDhluA. His blog and other content are available at http://www.thefatemperor.com/subscribe where subscription is free and the science is rock-solid. https://www.youtube.com/watch?v=NSPcuGjstN4 Listen in today as Jimmy and Ivor talk about the new science that brought about a new understanding of ApoB/LDLp role in cardiovascular disease and how to tell when it is important, and when it is not, why we've been fooled by total cholesterol , how the total cholesterol scare  was found to be crap so it was dumped for the sexy new LDL cholesterol, and why we now know that was utterly misleading.....so the new terror is ApoB/LDLp counts, the new Cholesterol Guidelines from AHA/ACC in the US - what's new, particularly around CAC, recent conferences e.g. Low Carb Mallorca and the guests Ivor interviewed there for his podcast series, the documentary Widow Maker, his new book, and much more.   Ivor's blog The Fat Emperor: TheFatEmperor.com/blog Ivor's interview The Livin' La Vida Low-Carb Show ep 843: Ivor Cummins Brings An Engineering Approach To Solving Health Problems Guest Lecture from LLVLC episode1397: Ivor Cummins & Dr. Jeffry Gerber – 2017 Low Carb USA San Diego  

In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject of lipids. In Part II, Tom provides a 101 on lipids and lipoproteins. Tom and Peter also discuss the history and techniques used to measure lipoproteins, and more.   We discuss:  Lipoprotein basics [1:30]; Gofman and the ultracentrifuge [5:15]; Lipoprotein structure, function, metabolism [6:45]; Lipoprotein and cholesterol measurement, and NMR technology [15:15]; LDL-C vs LDL-P and apoB [30:45]; Sterols and cholesterol synthesis [39:45]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

In this episode, Dave Feldman, discusses his journey from software engineer to n=1 experimenter, his experience with low-carbohydrate diets, and his hypothesis that cholesterol levels are influenced by energy metabolism.   We discuss: Peter’s synthesis of Dave’s energy model [5:00]; Dave’s journey from software engineer to cholesterol enthusiast [15:00]; Standard blood panels, sterol panels, and what moves the needle when it comes to particle numbers [18:30]; Hyper-responders [20:00]; Lipoprotein transport [33:45]; The lean mass hyper-responder phenotype [47:30]; The progression of atherosclerosis, CAC, and CIMT [52:30]; Testing for oxidized LDL [55:30]; All-cause mortality and clinical endpoints [1:01:15]; What does “LDL as causal” mean? [1:05:15]; Dave’s low carb cholesterol challenge and drug & genetic study qualifications [1:13:15]; If all other markers are in an healthy range, but LDL-P is high, is the patient at risk? A couple of case studies, and a self-experiment [1:27:30]; Peter’s three-day exercise and ketosis experiment [1:41:00]; What are remnant lipoproteins? [1:45:00]; What might cause lean mass hyper-responders to have higher LDL particle numbers? [1:53:30]; A case study from Dave of a lean mass hyper-responder [1:56:30]; Mass balance and cholesterol flux [2:05:30]; Can a higher degree of cholesterol explain the lean mass hyper-responder phenotype? [2:10:00]; Peter’s LDL during his keto-fast-keto experiment [2:13:30]; Does substituting saturated fats with monounsaturated fats lower LDL-P and LDL-C? [2:15:45]; Dave’s carb-swap experiments [2:22:15]; Dave’s carotid intima-media thickness tests [2:41:15]; Looking for studies that stratify for high HDL-C and low TG alongside low and high LDL-C [2:53:00]; and More Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

“How can I optimize my health and longevity?” “How can I live a long time and feel good doing it?” “What supplements should I take for peak performance?” “What should my ideal diet look like?” Honestly, without any data about your blood and biomarkers, you have no idea. This is because unless you know what your blood looks like under a microscope, there is no way for you to identify with 100% confidence what steps you should take to eat the right diet, to take the right supplements, to protect your health, to enhance your well-being, to perform at peak capacity, and perhaps most importantly, to live as long as possible with as high a quality of life as possible. Enter blood testing. Blood testing is the most important step you can take to identify and prevent life-threatening diseases before they happen to you. With your blood test results in hand, you can catch critical issues in your body before they manifest as heart disease, cancer, diabetes, or worse. Knowledge of exactly what is going on inside your body empowers you to implement a science-based disease-prevention program that can literally add decades of healthy years to your life. And if your goal is to not only stop disease, but to also perform at your peak physical and cognitive capacity, blood testing is absolutely crucial for identifying which diet, which supplements and which lifestyle steps you should take to optimize your specific and unique health parameters. But sadly, most annual medical check-ups that the average physician orders are simply routine, old-school blood tests that don't even test for the most important markers of disease risk, and that are simply designed to make sure you're “not dying”. They aren't designed to optimize longevity or to ensure your body is completely primed to perform at peak capacity. What most people don't realize is that you can skip your physician and simply manage the entire process for getting your blood work done yourself. And if you want to test absolutely every little thing that affects your organs, your energy, your hormones, your health and your longevity, then you've found the ultimate answer. I worked closely with WellnessFX, America's top laboratory for concierge blood testing and online access to all your blood testing results, to develop the and , which is the most complete blood testing package for men that money can buy.  This is by far the most comprehensive blood testing package I recommend and is designed for the high performer, biohacker or anti-aging enthusiast who wants access to the same type of executive health panel and screening that would normally cost tens of thousands of dollars at a longevity institute. The panel I discuss in today's podcast dives deep into overall metabolic functioning for optimal long-term health and longevity, and includes thyroid function, stress response, blood glucose regulation, sex hormone balance, heavy metals, inflammation, organs of detoxification (liver, kidneys, gallbladder, and lungs), proteins, electrolytes, blood oxygen and nutrient delivery, immune system status, vitamin D status and much, much more, including: 25-Hydroxy-Vitamin D Apolipoprotein A-1 Apolipoprotein B Blood Lead Blood Mercury Cardio IQ Lipoprotein Fractionation Ion Mobility Complete Blood Count w/ differential Complete Metabolic Panel Copper Cortisol Dehydroepiandrosterone Sulfate Ferritin, serum Fibrinogen Folate Free Fatty Acids Hemoglobin A1c Homocysteine High-sensitivity C-reactive protein IGF-1 (Growth hormone surrogate) Insulin Iron, TIBC Lipid Panel Lipoprotein (a) Luteinizing Hormone Omega 3 Fatty Acids RBC Magnesium Reverse T-3 Selenium SHBG (sex hormone binding globulin) T-3 Total T-3 Uptake T-4 (Thyroxine) T-3 Free T-4 Free Testosterone + Free Testosterone Thiamine Thyroglobulin Antibodies Thyroid Peroxidase AB TSH Uric Acid Vitamin A Vitamin B12 Zinc Estradiol As you can see, I've held nothing back and covered all bases with this customized blood panel. You will not find a test this comprehensive anywhere else, guaranteed. From identifying disease to optimizing longevity and anti-aging to maximizing performance, this test gives you absolutely everything you need. During this podcast, in which I cover my own results from my recent longevity panel, you'll discover: My own process of testing my blood. I had 19 tubes of blood drawn; you typically have 3-5 tubes drawn in a blood test. My motivation: What if you want the same type of blood test that would be tens of thousands of dollars at a longevity center? I wanted to advise myself with more precision than typical blood tests such as TSH. I designed a package with Wellness FX, for men and women. I do this on a quarterly basis; although once a year (or once per life) is sufficient for most people. First thing you see on the report: cardiovascular health. Basic lipid panel. Risk factors: Red (high caution); orange (pay attention); green (good to go). A lot of red doesn't necessarily mean a bad thing; all green doesn't necessarily mean all good either. My total cholesterol is red: 267. High cholesterol isn't a risk factor; it's when it becomes oxidized. My HDL levels are through the roof: 151. High level of HDL could mean your body is carrying a lot of metabolites to the liver due to constant inflammation. I tested all my inflammations, all very low. Question to ask: are you a lean mass hyper responder? Could have a higher LDLP particle count. High HDL, inflammation is low, not of concern. High cholesterol and high inflammation, be concerned. Below lipid panel you'll see LDL particles. I use the Thorne multivitamin. The chlorogenic acid you find in artichoke extract is efficacious in lowering APOB My peak LDL size has been climbing; ideally I want it above 222 1/2. My LDL particle count is actually low. Small low density lipoprotein low compared to peak LDL size. Overall I'm happy with my results. Look for increase in the size of my LDL particles. “How can I live a long time and feel good doing it?” Free fatty acids associated with diabetes and heart disease. Omega Index: two different fatty acids in your red blood cells. Arachidonic acid levels are normal; I feel like I could step up my Omega 6 fatty acid intake. (Sprinkle hemp seeds on your salad.) Metabolic health: Risk factors for diabetes and insulin resistance. You want your insulin levels relatively low. Wellness FX will give suggestions on how to lower insulin levels. My blood glucose level wasn't concerning, but a bit higher than normal. Homa IR score: Takes both glucose and insulin levels into account. A ratio of glucose vs. insulin. Thyroid health: You typically see only TSH. Mine has much more... My antibodies to thyroid are very low. Reverse T3 is very low; not concerned about stress. Free thyroxin index is normal. Thyroid peroxidase is a target of antibodies. I have low T3, T4, both total and free. My natural weight is 190-195; my actual weight is 175. I rarely eat until I'm full. Metabolic hormones: IGF is a bit low; I'll take colostrum for this. Cortisol: It's at 24; I want it between 2-20. If it's elevated on one snapshot, consider testing again. Cortisol metabolites. Dutch test for hormones. (link needed) Liver and Kidneys: High levels of creatinine; if you exercise prior to a lab test, the creatinine will be elevated. Blood urea nitrogen elevated. Forms when proteins break down. Elevates when people are a) dehydrated or b) exercised the day prior to the test. My liver values are of concern. ALT when elevated mildly not of concern; mine have raised each of the last 3 tests. Foods that are good for the liver. “What supplements should I take for peak performance?” Milk thistle Holy basil Dandelion root Non-alcoholic fatty liver disease. I may fall into this category. Metabolism Reset Diet by Dr. Allen Christianson (link needed) Something I do to sleep on int'l flights: an edible of marijuana. Metabolized by the liver; could have contributed to my high levels. Electrolytes Looking at Co2 and chloride levels. My Co2 has dropped. Bone health: More Vitamin D is not better; Above 80 you have increased risk of mortality. If calcium is abnormal, can be caused by abnormal albumin. The blood: You have two components of your blood: cellular (red, white, platelets) and liquid (plasma). My mean platelet volume is okay. My white blood cell count looks great. Either too little or too much can lead to mortality. Red blood cells: Look great. I spend time in the sauna which is great for blood production. My iron levels are fine. An extra steak or two per week wouldn't kill me. Floradix (link) Vitamins and minerals: Folic acid is essential for DNA synthesis. When folate is high, it could mean using a lousy multivitamin. Vitamin B12 is required for proper nerve function; mine is through the roof. Vitamin A is in perfect amount. Red blood cell magnesium the most precise way to measure magnesium in cells. Copper needed in trace amounts. Zinc important for nails, DNA synthesis, chronic disease management; too much causes bad breath, excessive sweating. Black ant extract is great for zinc. Resources from this episode: [pdf-embedder url="https://bengreenfieldfitness.com/wp-content/uploads/2018/09/Lab-Results-WellnessFX.pdf" title="Ben Greenfield Lab Results – WellnessFX"] - - - - - - - -Almsbio Glutathione with Q10 - - - - - - - - - - - - - Episode sponsors: - are the foundation of total human optimization. I highly recommend their toothpaste! Use my link and get 10% off your order. - Give the middle finger to aging. Use Kion Serum anywhere you’d like more vibrant, youthful skin and hair.   - It’s like having a personal trainer in your pocket. Inspiring music, inspiring trainers guiding your through your workout. Use my link and get 30% off a new membership. - Reclaim your inner-warrior. Have more energy. Boost your libido. Jet Pack is like a cup of coffee for your crotch. Enter code “ben” and get yourself 15% off your order at checkout. Do you have questions, thoughts or feedback for me about these lab results? Leave your comments below and I'll reply ASAP!

Sought-after TED speaker, low-carb physician and researcher Sarah Hallberg, MD, is conducting research (in humans, not rats) to help us better understand how low-carb high-fat (LCHF) or ketogenic diets affect our metabolism and heart. Hallberg et al. recently reported that LCHF diets don’t clog arteries as we might have expected; instead, they actually decrease parameters linked to heart disease. This episode is brought to you by: ➢ Health IQ, an insurance company that helps health conscious people like nose-breathers, weightlifters, cyclist and keto dieters get lower rates on their life insurance. ➢ Get a Free Quote and see if you qualify: http://healthiq.com/HIH   In this new show, Dr. Hallberg discusses the details: After following the “standard of care,” Dr. Hallberg witnessed her overweight and diabetic patients getting sicker and more dependent on medications. Since she shifted her “prescription” to diet and exercise, her patients are healthier and drug-free. Watch the interview: https://highintensityhealth.com/231   --------------------------- Key Timestamps-----------------------------   03:50 When Dr. Hallberg opened a low carbohydrate clinic, they quickly saw weight loss and reversal of diabetes. 05:51 Dr. Hallberg is part of the largest and longest trial of nutritional ketosis as a treatment to reverse type 2 diabetes. 07:40 Exercise, low carb and keto are now considered as treatment options for obesity. 08:42 Medications for diabetes treated symptoms, but not the progression of the disease.. Each step up in medication speeds the cycle. 13:29 Continuous glucose monitors allow you and your doctor to see what blood sugars are doing between finger sticks.. 16:28 Remote Care/Telemedicine gives better care remotely by personalizing an individual’s care.  It brings care to the patient. 19:35 Virtahealth is available in all 50 states. 20:35 Most Americans have some sort of metabolic issue. Over 50% of adults in the US have diabetes or pre-diabetes. 24:12 With nutritional ketosis, you can reverse diabetes AND improve cardiovascular risk factors, such as significant decreases in blood pressure, significant increases in good cholesterol/HDL, and a significant decrease in triglycerides. 26:41 A better cardiovascular risk marker than LDL is LDL-P for type 2 diabetics or those with insulin resistance. 27:18 Inflammation markers, especially C-reactive protein (CRP), decreased by 40% over the study year. 33:38 It is best to consume 3 to 5 grams of sodium a day 34:25 Patients in the study with high blood pressure had reduced blood pressure while reducing blood pressure medications and at the same time, consuming more salt. 35:48 Biomarkers most commonly used at Virtahealth are blood pressure, weight, blood sugar and serum ketones. 36:10 Serum ketone goals are above 0.5 mml of beta hydroxybutyrate. There may be a role in ketosis even at lower levels. 36:34 Diabetes medications lower blood sugar acutely, but cardiovascular outcomes were not improved. With SGLT-2 inhibitors, there was improvement with cardiovascular mortality. 38:44 SGLT-2 inhibitors block the SGLT-2 path in the kidney, not allowing reabsorption of glucose, releasing glucose in the urine. 39:55 Metformin affects gut hormones and the microbiome, and has few side effects. 41:09 The American Diabetes Association guidelines are not evidence based. 42:00 DASH diet, recommended by the American Diabetes Association can make diabetes worse. 47:58 We need to change the dietary guidelines to ensure that they are evidence based upon a rigorous systematic scientific process. 50:51 For proper meta-analysis, you need to pay attention of the inclusion criteria. Sometimes studies that do not meet criteria are included and others that do meet criteria are omitted. 55:56 Dr. Hallberg’s optimal morning routine includes black coffee and an early email check. She feeds her kids fat and protein and packs their lunches.  59:55 Dr. Hallberg’s favorite low carb/high fat food is pizza with cheese/almond flour crust. 60:45 Dr. Hallberg’s elevator pitch is that our dietary guidelines need to be reformed, as they impact all of us. Watch the interview: https://highintensityhealth.com/231  

What is cholesterol? Cholesterol is a waxy, lipid in every cell’s membrane and our blood plasma, vital for life It insulates neurons Building cellular membranes Metabolizing fat soluble vitamins Produces bile to help digest food Synthesis if many hormones including sex hormones There are rare genetic disorders in which people cannot properly synthesize cholesterol.  Once such disease is Smith-Lemli-Opitz syndrome (also called “SLOS,” or 7-dehydrocholesterol reductase deficiency) which is a metabolic and congenital disorder leading to a number of problems including autism, mental retardation, lack of muscle, and many others. You get some cholesterol from the your diet and some your body makes. Cholesterol is different day to day All Cholesterol is NOT created equal. The tests your doctor runs do not tell the whole story Many (not all) people will have increase in cholesterol on a high fat diet but most studies show IMPROVED cholesterol profiles (inc in good cholesterol, decrease in bad) So the AHA is right. Saturated fat does increase cholesterol. But does this mean it increases heart attack?  Probably depends what you are eating the saturated fat with and your genetics. The good (HDL), The bad (TG) and The ugly (LDL) HDL (the Good) Transfers excess cholesterol that tissues don’t use back to liver Liver excreted through bile HDL is the one to naturally help get rid of excess cholesterol when the body’s done with it, You want it as high as possible Increased by LCHF / Keto Triglycerides: (THE BAD) (causes fatty liver and heart disease) TG are fuel for your body High TG in blood because your body is not using it Its using glycogen instead If fat adapted - you are using this up TG just sit  around and cause problems TG float around in circulation Because hard and dense and causes problems/ plaques It starts to get oxidized Damaged and clogged arteries Your body tries to clear it with local inflammation Cells responding to inflammation cause plaque and clog arteries Arteries are narrowed and less blood and less oxygen TG increase small dense LDL LDL: (the ugly) - because its complicated LDL delivers cholesterol to tissues. Large fluffy LDL does this SO IMPORTANT LDL-C (large and fluffy) and LDL-P (go to artery walls and clog) ApoB (a proxy for LDL-P which not many labs run) Apolipoprotein B (ApoB) is an important component of many lipoproteins that are involved in atherosclerosis and cardiovascular disease. Apo B containing lipoproteins are the ones that are most likely to enter the wall of the arteries. TAKE HOME If you are not going to change your lifestyle and eat high sugar diet and you have heart disease - you might want to take a statin If you eat low carb high fat your cholesterol panel will be different then someone on a SAD Make sure you get the break down of particles to get a better picture Currently, most people in the United States (and the world for that matter) undergo a “standard” lipid panel, which only directly measures TC, TG, and HDL-C.  LDL-C is measured or most often estimated HIGH Triglycerides is BAD HIGH HDL is GOOD LDL-C is large fluffy and healthy GOOD LDL-P vs ApoB is small and dense and bad LDL-P (or apoB) is the best predictor of adverse cardiac events, which has been documented repeatedly in every major cardiovascular risk study When looking for information look to lipidologists who have phDs in this stuff not correlational / drug company funded research (mostly what doctors are aware of) https://idmprogram.com/diet-heart-hypothesis-hormonal-obesity-xxxv/ https://peterattiamd.com/the-straight-dope-on-cholesterol-part-i/ http://eatingacademy.com/cholesterol-2/the-straight-dope-on-cholesterol-part-iii cbi.nlm.nih.gov/pubmed/27389628 https://www.marksdailyapple.com/cholesterol/ https://www.medicalnewstoday.com/articles/267834.php https://www.healthline.com/nutrition/23-studies-on-low-carb-and-low-fat-diets http://clinchem.aaccjnls.org/content/50/10/1725

Stephen Anderson has been an Acupuncturist and Chinese Medicine practitioner for nearly 20 years.  He’s had over 2500 patients and upwards of 40,000 consultations (that would be over 3/4 million acupuncture needles, but who’s counting). In 2016, Steve went through the Kresser Institute’s Practitioner Training Program for Functional and Evolutionary Medicine, completing the ADAPT Level 1 Framework.  Since then, his focus has shifted to working more with clients who are ready to make a deeper commitment to their health. Steve is on the podcast today talking about his transition into Functional Medicine and his practical application of our Blood Chemistry Calculator to guide treatment decisions and keep clients motivated.  Steve is currently running his busy clinic in Australia and is now introducing an easy way for Aussies to get lab work done locally and try the calculator for themselves. Here’s the outline of this interview with Stephen Anderson: [00:00:12] The Holistic Practitioner (THP) Podcast. [00:00:25] THP Podcast: Dr. Tommy Wood - Reframing Insulin Resistance. [00:02:07] Taichi. [00:03:30] Chinese Kung Fu Academy; Grandmaster Henry Sue. [00:03:58] Cheng Man-ch'ing. [00:04:29] Hypothalamic–pituitary–adrenal (HPA) axis. [00:07:48] Accelerated learning. [00:07:54] Book: How to Develop a Super Power Memory, by Harry Lorayne; Peg memory system. [00:08:09] Podcast: Learning to Learn with Jonathan Levi.  Course: Become a SuperLearner. [00:09:28] Acupuncture. [00:10:52] Polycystic ovary syndrome (PCOS). [00:12:30] Dr. Michael D. Fox at the Jacksonville Center for Reproductive Medicine. [00:17:13] Functional Medicine. [00:18:57] Simon Marshall, PhD. Podcasts: How to Create Behaviour Change and Why We Self-Sabotage (And What to Do Instead). [00:20:25] Kresser Institute for Functional and Evolutionary Medicine; ADAPT Practitioner Training Program. [00:23:16] Dr. Amy Nett. [00:24:11] Hierarchy of treatment. [00:25:52] THP Podcast: A Patient’s Perspective of Functional Medicine Treatment. [00:29:26] Blood Chemistry Calculator. [00:29:37] THP Podcast: Chris Kelly On Becoming An Effective Health Coach. [00:29:41] Dr. Bryan Walsh; Podcasts:  1, 2, 3, 4, 5, 6. [00:29:42] Megan Roberts; Podcast: Why Your Diet Isn’t Working: Under Eating and Overtraining.  Blog post: What We Eat and How We Train Part 1: Coach and Ketogenic Diet Researcher, Megan Roberts. [00:31:06] 7-Minute Analysis. [00:36:39] 5-year wellness score; Intermountain Risk Score. Study: Horne BD, May HT, Muhlestein JB, Ronnow BS, Lappé DL, Renlund DG, et al. Exceptional mortality prediction by risk scores from common laboratory tests. Am J Med. 2009;122: 550–558. [00:39:14] Thomas Dayspring, Peter Attia; LDL-P. [00:42:13] Familial Hypercholesterolemia. [00:44:17] Mediterranean diet, B-vitamins, Thorne Choleast-900 (Monacolin K), Ubiquinol, Glutathione. [00:46:35] Feedback via lab results as the incentive to change behaviour. [00:49:58] Coronary artery calcium scan; Podcasts: How Not to Die of Cardiovascular Disease, with Ivor Cummins; The True Root Causes of Cardiovascular Disease, with Jeff Gerber. [00:52:12] Podcast: Optimal Diet and Movement for Healthspan, Amplified Intelligence and More with Ken Ford. [00:53:14] stephenanderson.com.au/nbt.

In this podcast episode, we talk about cardiovascular labs with naturopathic cardiology expert, Daniel Chong, ND. Chong discusses the use of cholesterol panels and other tests he uses in practice. He dispels some common myths about how to interpret different lab results.   About the Expert Daniel Chong, ND, has been a licensed naturopathic physician, practicing in Portland, Oregon, since 2000 and focusing on risk assessment, prevention, and drug-free treatment strategies for cardiovascular disease and diabetes, as well as general healthy aging, and acute and chronic musculoskeletal injuries. Chong has also completed certificate training in cardio-metabolic medicine from the American Academy of Anti-Aging Medicine and is an active member of the Society for Heart Attack Prevention and Eradication (SHAPE). In addition to his clinical work, Chong serves as a clinical consultant for Boston Heart Diagnostics Lab. Tina Kaczor, ND, FABNO: Hello I'm Tina Kaczor editor-in-chief at the Natural Medicine Journal. I'm speaking today with my friend and colleague Dr. Daniel Chong a naturopathic physician and specialist in cardiology specifically. Dr. Chong is a founder and lead consultant at healthyheartacademy.com as well as a consultant for the cardiology industry. Dan, thanks for joining me today. Daniel Chong, ND: Hello Dr. Kaczor, it's nice to be here. Kaczor: We have talked informally, and I thought this would be a great opportunity to talk specifically for our audience, about the use of cholesterol panels, and we'll go into specifically some breakdown of the usefulness of common cholesterol panels, and then break that out into more particular cardiology panels. There's a lot out there right now about whether cholesterol is or isn't even linked to heart disease, so let's just start at the beginning. Can you give us a little bit about the roots of the cholesterol theory? We'll branch off from there. Chong: I can try. It definitely is a relatively long-standing theory now. As I understand it, the first thoughts as to whether or not cholesterol had anything to do with cardiovascular disease came in the early 1900s on animal research with rabbits, but at that point it was dismissed because people were still not clear whether or not you could make any correlations between findings in rabbits and extrapolate out to humans. The major real focus on the connection between cholesterol and heart disease started more in the mid-1900s almost simultaneously in a way with Ancel Keys and the Framingham study, so they started around the same time. Ancel Keys was one of the first people to really make a point of saying, "We should really research this because we repeatedly are seeing this potential connection," and so he was one of the first people to really start trying to splice it out. Then, the Framingham study started simultaneously. They don't come out with any of their more definitive conclusions until a little later than him with that. That's where it all began as far as I understand it. Kaczor: In the Framingham study specifically I know that there has been ... The broad interpretation in the professional world has been high cholesterol equals risk of heart disease, LDL being the "bad cholesterol," in general. Is there particular subpopulations that this is more true for? In other words, can we say if you are a 40 or 50 something-year-old male this is more true than if you're a 80-year-old male, or a female? Is there any way to delineate that with just looking at broad generic cholesterol levels, nothing too specific yet? Chong: Hopefully, it will be answering your question by saying this, but to me one of the most fascinating pieces of information I heard come out of the Framingham study in particular is that over the course of however many years ... this was a statistic we heard about maybe five or so years ago. The Framingham study had been active for well over 50 years and they had well over 50 years of data on how many thousands of people, and the statement was made by the former director of the Framingham study, so it was certainly legitimate. Essentially what they said was, one of the key pieces of information that they saw in terms of the relationship between at least total cholesterol and cardiovascular disease was that it appeared as though if a person's total cholesterol was at or below 150 naturally, so throughout their lives without necessarily an intervention with a drug or whatever, just the people in the study who had naturally low cholesterol did not get heart disease period. Of course, you can't then take that and make any truly definitive statements, but there is, in terms of a general viewpoint that was one of the things that came out. In other words, nobody with cholesterol under 150 naturally got a heart attack in their study. Again, there would still need to be more done to splice that out and figure out what exactly is going on there and why that is, but there's definitely something to be said. You can see the same exact type of finding if you look at epidemiological research on different cultures of people in history who did not get heart disease or got very little heart disease, all of those people regardless of where they were on the planet, what types of specific foods they were eating, even to some extent what their lifestyle was some of these people smoked, et cetera, the cultures of people who were known and found not to get cardiovascular disease all had cholesterol at or below 150. Kaczor: You're talking about total cholesterol? Chong: Correct. Kaczor: Let's move over to talking about the bad cholesterol. LDL- Chong: Can I pause you for one quick second? Kaczor: Yeah. Chong: Just to say one other thing about that. There's a lot of questions that would be immediately raised from those statements that I just made. One other way that I look at things is, and I know we'll get into it more, but cholesterol in of itself, I will say right from the beginning, has to be involved. It is not a worthless thing to measure, it is not something to just disregard and only focus on information. Time and again it has to be involved, technically it has to be involved. You can't make plaque without it, but it's just an important way to think about it. It's just whether or not it's the primary causative factor and we'll get into that. Kaczor: Yeah, that's an important point. I don't see many people with total cholesterol below 150, but we'll put that aside. It's pretty uncommon. I don't know about other people. Let's break it down- Chong: In modern times it absolutely it is. Kaczor: Let's talk about LDL specifically and just start out with there's a lot of more specific labs that are looking at LDL particle size rather than total LDL. Just a brief primer, if you would, on the difference between LDL- Chong: I like your emphasis on brief. Kaczor: Yeah. Chong: Sorry, go ahead. Kaczor: On LDL calculated as it is in a common cholesterol panel and the particle size as it is measured by several different labs now. Chong: I'll do two separate simple ways that I look at it. One is technically LDLC or "LDL cholesterol" measurements that are most commonly done in the average physicians' offices et cetera is technically measuring the mass or total amount of cholesterol being carried around on LDL molecules. Just as a reminder to people, these LDL molecules are protein-based particles that are essentially like cargo ships carrying around different substances, one of the main ones being cholesterol. When you are getting an LDLC you are getting an estimate of the mass of the total amount of cholesterol being a carried around by all of the LDL particles in the system whereas, an LDLP is specifically getting a count of the LDL particles floating around in any one measurement of blood. From an analogy perspective it's like you're counting either the cargo that's being ... The Pacific Ocean has a certain amount of cargo ships out in it carrying cargo and LDLC is like, "Okay, what's the estimate of total cargo being carried around by all of those ships?" Whereas an LDLP would be like, "Okay, we're going to go into the ocean, we're going to count each one of those ships and see how many there are." Depending on some different factors this is why you could theoretically ... Let's say a cargo ship could technically carry 100 pounds of cargo, you could technically have two ships carrying 200 total pounds of cargo or you could have 20 ships carrying 10 pounds of cargo each. In both cases the LDLC would be the same and yet one, there's 20 ships and the other there's two ships, if that makes sense. The reason why that's so important to make the distinction is that what we know now is that risk specifically goes up with ship count or particle count—not necessarily total mass or total cargo. If you have a way of identifying, "Aha, there is actually only two ships in this ocean versus 20," that can significantly impact risk level. Kaczor: Looking at the LDLC, which is the calculated one, it may or may not correlate with cardiovascular disease is what I'm hearing you say, and LDLP we can use as a more specific correlation with cardiovascular disease. Chong: Right, that is correct. In the grand scheme of things when we're also potentially considering other factors like inflammation, and oxidative stress, et cetera, it's still relative ... we're just talking about cholesterol-related markers and their impact on risk, so there are obviously ... I don't want to discount the fact there are other factors involved here, but when we're just talking about the cholesterol and its impact on future risk or not the particle count is what trumps everything. Again, just in the realm of the cholesterol markers. Just for an example, there's a research study I've seen where they looked at 16-year survival, from year 0 to 16 and measured LDLP and LDLC in each person. This is a very large study, and what they saw is a distinct difference between particle count and future event risk for cardiovascular disease. In other words, you had a distinct increase or higher rate of survival in people who have low particle counts regardless of what their LDLC or mass was. Whereas the people with worse outcomes all had high particles even though some of them technically had low LDLCs or low amount of total mass or cargo. Kaczor: It's been- Chong: It's been clearly seen that there's a distinct difference. It's also important to mention here, it is unfortunately true that there are some people out there who are still saying, "If I have large puffy LDL (i.e., my LDL particles are loaded with a lot of cargo per particle) and yet not necessarily ..." If you have a high LDLC, but all of your LDLs are large and puffy, and you also have a high LDL particle count you will still have an increased risk. There are some people out there who are under the misconception that if LDL particles are large and fluffy or large and puffy enough they can't cause problems, that's totally inaccurate. Bottom line, when we're talking about LDL, particle count trumps everything. Kaczor: Let's move on to HDL. That's really good points on the LDL because I do know that the size and the type, the fluffy or the dense, that idea is very much part of the verbiage that patients use when they come through the door- Chong: I'm sorry, I will say one other thing quickly about that. I don't mean to say that it's worthless to check LDL particle size because it's still true that LDL particle size, the smaller the particles the higher the potential is for future risk, but it's not just because of the mechanism itself. It's like just because there is a strong relation between what causes LDL particle sizes small and what causes cardiovascular disease. As an example, typically people with poor insulin sensitivity, or insulin resistance, diabetes, et cetera tend to have smaller particles, so it's still important to look at particle size because it does add to the predictive value of the test you're running. I don't mean to say that it's worthless or anything like that, you just can't say, "If my particles are large and puffy, I don't care how many there are." Kaczor: Got you. Okay. Let's go back and just come back to HDL, the high density lipoproteins. This we don't harp on as much, the drugs aren't targeted towards it as much. We tend to know that higher is better. How do you use HDL in your interpretations? Chong: One of the reasons why the drugs aren't targeted as much is because they keep trying and failing. Pretty much every study that's ever been done on a drug that it raises HDL shows that they clearly work and then oftentimes the people die sooner, so they have to stop. The bottom line is it's not a cut and dry direct simple relationship where the higher the HDL the better necessarily. Especially if you make a change in somebody, so like diet, lifestyle, et cetera, and their HDL goes up it is absolutely not a guarantee that they are getting better or that they are more cardio protected than they were beforehand. It might be the case, but it's not a certainty. From that perspective, at least personally, when I'm looking at HDL I'm always looking at the whole picture. If I see a relatively low HDL and yet this person might happen to be one of these lifelong naturally low in total cholesterol, naturally low in LDL people I'm not as concerned about that low HDL as I am in somebody who has really high LDL, really high total cholesterol, insulin resistance, et cetera, and they have low HDL. There's a definite difference. Those two people might both have the same HDL number, but one is way more concerning than the other one, and it just has to do with the role of these particles, these molecules, and what are they doing for us? If you really simplify it down HDL does a lot of complicated things, we still don't even know everything that it does, but definitely one of its main job is reverse cholesterol transport where it's helping to remove excessive cholesterol deposited in the periphery so to speak. I like to look at it as a garbage truck or a garbage collector. It is very true that if you do have a lot of "garbage" in the system, you have a high total cholesterol, a high LDL there's lots of cargo, or garbage, or whatever you want to call it being shipped outward you would hope to see the body responding to that by increasing garbage truck count to pick up the extras. You commonly see that on people who go onto low-carbohydrate, high-fat diets. Oftentimes you will see, hopefully, an elevation in HDL as the body is literally just adapting to the additional load on the system that you're putting on it. It does not, however ... Unfortunately, you can't take that response and then conclude that the low-carbohydrate diets are cardioprotective because they cause HDL to go up. It's not that cut and dry, it's more just that the body is responding and having to increase its HDL to adapt and make up for the extra amount of cholesterol in the system, if that makes sense. It's quite complicated. You do see HDL go up for that reason. The other thing is sometimes you'll see high HDL in somebody who's got disease, especially if they're inflamed or they have chronic inflammation. In those situations, in all likelihood, what's going on is that inflammation is known to hinder HDL function. The body always trying to adapt, always doing the best that it can to deal with the cards it's being dealt, if it has poorly functioning HDL it's going to spit out more of them in an effort to continue doing the job that needs to be done. If the HDL are dysfunctional as a result of oxidative stress, inflammation, et cetera in the system if the person has the capability you may sometimes see HDL production go up or HDL number go up on the person's lab because each one is not working as well as it should. Kaczor: That's an interesting idea, that it's a reaction. Chong: Absolutely. It's a fluid, functional system. Again, people just think, "Oh, HDL went up, that's good," or whatever. It's not like that. You have to think about why is the body doing that? What is the response going on? The body's always trying to maintain homeostasis, which would include not having cholesterol collect in the walls of the arteries. Kaczor: That's awesome. I appreciate that perspective. I think it's really helpful for us because we want the quickest most linear path to a conclusion, so it's good to remember to step back once in a while. Chong: For sure. Kaczor: We don't have time to go into labs, other labs in great detail, but what other laboratory parameters would you consider must haves? I'm going to give you a typical case, a patient comes to your office, they themselves have no history of cardiovascular disease. They have both sides lots of cardiovascular risk, so they believe that maybe there might be something going on there. What's your bare minimum of labs? What would you do? Chong: Especially in today's world where we're not necessarily billing insurance or whatever personally, for me, if I'm trying to get the most bang for my patient's buck in the realm of cholesterol I'm going to measure an apo A1, or apolipoprotein A1, I'm going to measure an apolipoprotein B, which for those people that aren't fully aware it's essentially like getting more precise HDL and LDL. Apo A1 is like getting a bit more precise HDL count and apo B is like getting a more precise particle count. Again, that's the name of the game, especially looking at the ratio between those two. I'm also going to measure a lipoprotein a, which has its own independent impact on things and is not necessarily going to be responsive to medications or dietary changes that do impact these other markers. It's a very important marker to assess and you can never really predict whether or not somebody's going to have high levels of that or not, but definitely the potential goes up with a strong family history. Then, beyond that in the realm of inflammation I'm at least going to want to see an HSCRP, I'm at least going to want to do some fundamental blood sugar metabolism related markers. I personally like to check a fasting insulin, and then potentially a hemoglobin A1c as well, although that sometimes has some questionable value depending on each patient. Beyond that, it starts getting a little bit more spliced out and potentially, depending on each patient, what you might go from there. I do check vitamin Ds pretty often, I check ferritin, and iron binding capacity pretty often at least screening that once to make sure there's no hemochromatosis going on. Those are probably the main ones I'm going to want to see. I will definitely do a CBC as well. Kaczor: The one I didn't hear you say, and I'm curious if you do, is homocysteine. Chong: Sorry, thank you Dr. Kaczor. Yes, absolutely homocysteine as well. Again, whenever I have the opportunity especially if there is a strong history and there's good reason to want to delve more deeply than average there are definitely some other markers I would typically run with people, but those would be a great starting point. I don't know if we're going to talk later about going outside of blood tests, but just long story short I don't consider an assessment truly complete without some type of imaging at least on the high risk population. Kaczor: By that, you mean? Chong: Sorry, carotid ultrasound, IMT, or a coronary calcium score. Kaczor: I can vouch for that. I've had several patients with cholesterols that didn't look too impressive, but their coronary calcium scores came back very, very good, and so they didn't have any [inaudible 00:24:42]. Chong: I will say one pearl type of information about that, the value of coronary calcium scores specifically goes up with age. The value of risk assessment using that test goes up with age. In other words, occasionally if a person is still relatively young, typically under about 55, you may have a situation where that person has a decent amount of soft plaque that has not been calcified yet and it will make their calcium score looks pretty good, but then if you check a carotid ultrasound it doesn't look so good. I have seen some mismatches in that regard with some of the slightly younger people, so my tendency is to measure carotid ultrasound, IMT tests with the understanding, obviously, that you're not checking the coronary arteries, but there's an over 90% correlation between the two. To me, a carotid ultrasound is a little pickier, a little more fine-tuned than the other one, but absolutely the high calcium score is a very powerful risk predictor. It's just whether or not you're going to catch everybody that way. Kaczor: Great. Dr. Chong, thank you so much for joining me today, I appreciate your expertise, taking the time. I think this is a to be continued type of thing because we didn't talk about what to do. Chong: I would love to keep talking, yes because I feel like we just started scratching the surface. Happy to delve more into some of these other details because there's a lot of other things to consider. Kaczor: We'll talk about treatments and we can talk a little bit more about imaging techniques next time. Thanks again. Chong: Super, yeah. Thank you.

Dave Feldman is a software engineer who discovered for himself the benefits of a ketogenic diet in April 2015, experiencing what he describes as “seven blissful months” - until getting some labs back that included a 300+ total cholesterol.  He learned he was a “hyper-responder,” which inspired him to learn all he could about cholesterol and the lipid system. For the last 2.5 years he’s been using self-experimentation methods to meticulously adjust dietary macronutrient ratios in order to manipulate his blood chemistry.  He’s found out that the lipid system is actually quite easy to change, and does so in surprising ways related to diet. Dave is here today with Dr. Tommy Wood to share his discoveries about all things cholesterol: LDL, HDL, VLDL, lean-mass hyper-responders, and what you need to know to evaluate your own labs.  Dave is an active speaker and blogger, and his N=1 experiments are detailed on his blog at cholesterolcode.com. Here’s the outline of this interview with Dave Feldman: [00:00:19] Video from Low Carb Breckenridge 2017: Dave Feldman: The Dynamic Influence of a High Fat Diet on Cholesterol Variability. [00:00:47] Dave’s background. [00:01:17] Cholesterol doubled, hyper-responder. [00:01:54] Distributed object networks. [00:02:46] Changing fat intake to manipulate cholesterol levels. [00:03:01] Cholesterol Drop Protocol. [00:05:27] Reverse engineering cellular energy. [00:06:20] Lipoprotein. [00:09:37] Very low-density lipoprotein (VLDL), triglycerides. [00:10:00] Metabolic syndrome, insulin resistance. [00:10:29] Intermediate density lipoprotein (IDL). [00:14:35] Hydrolysis of fatty acids. [00:17:11] 3-day average, LDL-C, LDL-P. [00:19:05] Nuclear magnetic resonance spectroscopy (NMR), Friedewald equation. [00:21:00] Direct vs Calculated LDL-C. [00:23:25] Non-low carbers. [00:24:15] Carb swapping. [00:27:16] Vegans. [00:28:07] Sex hormones. [00:29:35] Metabolic flexibility. [00:29:59] Lean mass hyper-responders. [00:34:59] Hypothyroidism, T3, testosterone, creatinine. [00:37:08] Dave’s interview with Ken Sikaris on Low Carb Conversations podcast. [00:37:34] All-cause mortality. [00:38:15] Study: Fulks, Michael, Robert L. Stout, and Vera F. Dolan. "Association of cholesterol, LDL, HDL, cholesterol/HDL and triglyceride with all-cause mortality in life insurance applicants." J Insur Med 41.4 (2009): 244-53. [00:40:00] APOC2, C-reactive protein. [00:44:44] 99% of the LDL particle lifespan. [00:45:59] Atherosclerosis. [00:46:31] Lipopolysaccharides (endotoxin). [00:50:23] Cyrex Array 2 - Intestinal Antigenic Permeability Screen. [00:52:15] Study: Varbo, Anette, Jacob J. Freiberg, and Børge G. Nordestgaard. "Extreme nonfasting remnant cholesterol vs extreme LDL cholesterol as contributors to cardiovascular disease and all-cause mortality in 90000 individuals from the general population." Clinical chemistry 61.3 (2015): 533-543. [00:51:38] Peter Attia, Thomas Dayspring. [00:53:23] Remnant cholesterol. [00:59:44] Cholesterolcode.com. [01:00:38] Low Carb Breckenridge, Low Carb Cruise, Ketocon, Ketofest, @DaveKeto.

For Episode 385 of The Paleo Solution Podcast we have a special guest: Dr. Shawn Baker M.D. Dr. Baker is an orthopedic surgeon, multiple record breaker in weightlifting, and has been eating a carnivore diet for the last 15 months. Listen in as we talk about all-meat diets, and go over Dr. Baker's recent blood work results. Show Notes: 1:50 – Opening Remarks/Summary 3:48 – Dr. Shawn Baker’s background 6:15 – All carnivore diets (and health and autoimmune disease) 12:46 – Athletics eating carnivore diet 14:45 – Concept 2 Rower 17:28 – Blood sugar swings 18:20 – Carnivore diet controversy and comparing to keto and mixed diets. 20:02 – mTOR and protein discussion 22:14 – Muscle mass and longevity 23:13 – Dr. Shawn Baker’s blood work 25:20 – C-Reactive Protein 27:10 – Fasting Glucose 30:15 – Blood Urea Nitrogen (BUN) 30:39 – Creatinine 30:50 – Cholesterol (general panel) 32:37 – Liver function (AST and ALT) 33:57 – More Cholesterol discussion 35:50 – Testosterone 40:38 – A1c 42:42 – Ferritin 44:21 – Iron related 45:57 – Insulin 47:55 – LDL-P 48:40 – LPIR score 48:55 – TSH 49:02 – Vitamin D 50:08 – Remnant cholesterol particles 50:41 – BMI 50:55 – Blood pressure 51:05 – HDL to Triglyceride ratio 53:09 – Lp(a) 54:54 – More LDL-P and cholesterol discussion (reverse discordance) 56:15 – More discussion on glucose (athletics and glucose) 59:05 – Where is Dr. Baker taking this next? (and salt and muscle pump) 1:01:05 – Fiber 1:02:26 – Fruits and vegetables 1:03:43 – Experimentation, science, and progression 1:08:51 – Where you can find Dr. Shawn Baker   Instagram: @ShawnBaker1967 Twitter: @SBakerMD World Carnivore Tribe Facebook Group MeatHeals.com Carnivore Training System https://nequalsmany.com/ Dr. Shawn Baker on the Joe Rogan Experience podcast: http://podcasts.joerogan.net/podcasts/dr-shawn-baker  

To interpret lab results your typical doctor will use standard reference ranges that are based on averages from a random sample of people.  Your labs are compared to these ranges to evaluate your health status and to guide potential treatment.  If reference ranges have such an important role, wouldn’t it make sense to have them reflect optimal health rather than typical health? We’re looking at some recent and large-scale studies today that suggest your cholesterol numbers don’t mean what mainstream medicine might have you believe.  Dr. Tommy Wood, MD, PhD is with me to discuss optimal reference ranges for cholesterol and triglycerides, as well as other lab tests that are more reliable for predicting cardiovascular disease and all-cause mortality. Need some help interpreting your blood tests? In this interview, we introduce the Blood Chemistry Calculator. Here’s the outline of this interview with Dr. Tommy Wood: [00:03:02] All-cause mortality: Dying from any cause. [00:03:38] Study: Fulks, Michael, Robert L. Stout, and Vera F. Dolan. "Association of cholesterol, LDL, HDL, cholesterol/HDL and triglyceride with all-cause mortality in life insurance applicants." J Insur Med41.4 (2009): 244-253. [00:05:54] Higher is not necessarily better for HDL. [00:07:23] Lower limits for triglycerides. [00:07:50] Study: Iannello, S., et al. "Low fasting serum triglyceride level as a precocious marker of autoimmune disorders." MedGenMed: Medscape general medicine 5.3 (2003): 20-20. Podcast: Risk Assessment in the Genomic Era: Are We Missing the Low-Hanging Fruit? With Dr. Bryan Walsh. [00:11:09] Arbitrary cutoffs are created in order to compare groups statistically. [00:12:25] Study: Zuliani, Giovanni, et al. "Combining LDL-C and HDL-C to predict survival in late life: The InChianti study." PloS one 12.9 (2017): e0185307. [00:13:19] Study: Orozco-Beltran, Domingo, et al. "Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study." PloS one 12.10 (2017): e0186196. [00:17:27] Total cholesterol. [00:18:44] Optimal reference range for total cholesterol: 120 - 240 mg/dL (under age 60, all-cause mortality). [00:19:55] Optimal range for women 200 - 300 mg/dL (over 60). [00:20:11] Study: Petursson, Halfdan, et al. "Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study." Journal of evaluation in clinical practice 18.1 (2012): 159-168. [00:21:46] Familial hypercholesterolemia. [00:23:01] LDL is part of the immune system. [00:23:32] Insulin resistance as a cause of high cholesterol. [00:24:23] Thyroid problems as a cause of high LDL. [00:26:19] Ivor Cummins (see first graph on page). [00:27:23] Optimal reference range of LDL for men/women under age 60:  80 - 170 mg/dL. [00:29:44] HDL graphs found within study: Fulks, Michael, Robert L. Stout, and Vera F. Dolan. "Association of cholesterol, LDL, HDL, cholesterol/HDL and triglyceride with all-cause mortality in life insurance applicants." J Insur Med41.4 (2009): 244-253. [00:30:42] Alcohol as a potential cause of high HDL. [00:33:01] Optimal reference range for triglycerides: 50 - 90 mg/dL. [00:35:23] Triglyceride : HDL ratio 1 - 2 is optimal if measuring in mg/dL. [00:37:16] Total cholesterol : HDL ratio of 3 - 4 is optimal. [00:39:32] Keto hyper-responders. [00:40:15] APOE4. [00:40:40] Thomas Dayspring. [00:41:01] True Health Diagnostics. [00:41:20] LDL-P: the total number of particles carrying the LDL cholesterol. [00:41:51] LDL particle size: small dense vs large fluffy. [00:42:33] Peter Attia’s blog and his posts pertaining to cholesterol. [00:43:08] Dave Feldman. His website: cholesterolcode.com. [00:45:37] Endurance exercise: effect on cholesterol and triglycerides. [00:46:23] Facebook groups: Lower Insulin and Optimising Nutrition. [00:46:43] Gudmundur Johannsson, CEO of the Icelandic Health Symposium. [00:46:55] Sepsis, endotoxins: worse outcomes with lower LDL. [00:49:39] Statins: Ever a good idea? [00:51:28] Tommy in a kiosk. [00:53:25] Link to the blood calculator.

Dr Jeffry N. Gerber, MD, FAAFP is a board-certified family physician and owner of South Suburban Family Medicine in Littleton, Colorado, where he is known as “Denver’s Diet Doctor”. He has been providing personalized healthcare to the local community since 1993 and continues that tradition with an emphasis on longevity, wellness and prevention. In this interview, Dr Gerber describes the major root causes of cardiovascular disease, the most important of which is insulin-resistant Type 2 Diabetes. Worried about your heart disease risk? Get a coronary artery calcium (CAC) score. Your CAC score (and the rate of progression of your CAC score) is probably the best easily-available predictor of cardiac events. A recent paper from the CARDIA study also showed that an elevated CAC score was highly predictive of long-term heart disease risk in younger adults (18-30 year-olds). Here’s the outline of this interview with Dr. Jeffry N. Gerber, MD: [00:01:27] Clinical experience. [00:02:27] Interest in low-carb diets. [00:03:21] Presentation: Ivor Cummins: “Roads to Ruin?” The Pathways and Implications of Insulin Resistance. [00:03:38] Book: Diabetes Epidemic & You by Joseph R. Kraft. [00:04:23] Professor Grant Schofield and Catherine Crofts, PhD. Podcast: Hyperinsulinaemia and Cognitive Decline with Catherine Crofts, PhD. [00:05:08] Hyperinsulinemia and CVD. [00:06:39] The 2 hour insulin test < 30 UI/mL. [00:07:20] Fiorentino, Teresa Vanessa, et al. "One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose." The Journal of Clinical Endocrinology & Metabolism 100.10 (2015): 3744-3751. [00:07:51] < 5 UI/mL fasting insulin. [00:10:40] What causes CVD? [00:11:49] Carl von Rokitansky. [00:12:02] Rudolf Virchow. [00:12:19] Blog: Dr. Malcolm Kendrick. [00:13:49] Russell Ross. [00:15:40] List of things that cause CVD. [00:16:44] Nitric Oxide. [00:17:43] Jerry Reaven. [00:19:19] Vega, Gloria Lena, et al. "Triglyceride–to–high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men." Journal of Investigative Medicine 62.2 (2014): 345-349. [00:20:17] The Framingham study. [00:21:53] LDL-P and advanced testing. [00:22:32] CAC score. [00:23:41] Intimal media thickness. [00:26:11] Ordering a scan. [00:26:41] 64-slice EBCT machine. [00:27:08] Valenti, Valentina, et al. "A 15-year warranty period for asymptomatic individuals without coronary artery calcium: a prospective follow-up of 9,715 individuals." JACC: Cardiovascular Imaging 8.8 (2015): 900-909. [00:28:15] Soft plaque. [00:28:57] CT angiogram. [00:29:44] Don't let perfect be the enemy of very good. [00:30:34] How to get a zero score. [00:31:28] Industrial seed oils. [00:32:02] D3/K2, magnesium, vitamin C. [00:33:29] Statins. [00:33:47] Absolute risk reduction data. [00:34:13] Ridker, Paul M., et al. "Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein." New England Journal of Medicine 359.21 (2008): 2195. [00:34:40] NICE guidelines for prevention of cardiovascular disease. [00:36:45] Studies: Puri, Rishi, et al. "Impact of statins on serial coronary calcification during atheroma progression and regression." Journal of the American College of Cardiology 65.13 (2015): 1273-1282, Sattar, Naveed, et al. "Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials." The Lancet 375.9716 (2010): 735-742, and Preiss, David, et al. "Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis." Jama 305.24 (2011): 2556-2564. [00:37:22] Interview: Calcification and CAC with the Expert: Professor Matthew J. Budoff, MD, FAAC, Part 1 and Professor Matthew J. Budoff Part 2: Primary Care Physicians and CAC. [00:37:41] Book: Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Longevity by Ivor Cummins and Dr. Jeffry Gerber – February 6, 2018. [00:38:50] Four body types: Skinny, insulin-resistant type, the overweight, typical T2 diabetic type, the overweight, insulin-sensitive type, and the metabolically healthy type. [00:40:50] Conference: Low-Carb Breckenridge 2018. [00:41:28] Dr Rod Tayler. [00:42:25] Dr Andrew Mentee and the PURE study. [00:42:46] List of speakers at Low-Carb Breckenridge 2018. [00:43:06] IHMC STEM-Talk Episode 41: Dr David Diamond talks about the role of fat, cholesterol, and statin drugs in heart disease.         [00:44:15] Dr Jeffry N. Gerber, MD, FAAFP. [00:45:27] Rebuttal: 9NEWS – Explaining the science behind the keto diet with Dr Jeffrey Gerber.

If you are interested in the low-carb, moderate protein, high-fat, ketogenic diet, then this is the podcast for you. We zero in exclusively on all the questions people have about how being in a state of nutritional ketosis and the effects it has on your health. There are a lot of myths about keto floating around out there and our two amazing cohosts are shooting them down one at a time. Keto Talk is cohosted by 10-year veteran health podcaster and international bestselling author Jimmy Moore from “Livin’ La Vida Low-Carb” and Pittsburgh, PA functional medicine practitioner Dr. Will Cole from DrWillCole.com who thoroughly share from their wealth of experience on the ketogenic lifestyle each and every Thursday. We love hearing from our fabulous Ketonian listeners with new questions–send an email to Jimmy at livinlowcarbman@charter.net. And if you’re not already subscribed to the podcast on iTunes and listened to the past episodes, then you can do that and leave a review HERE. Listen in today as Jimmy and Will peel back the layers of your low-carb, high-fat, ketogenic questions in Episode 85. BECOME A NUTRITIONAL THERAPY PRACTITIONER Sign up by February 2018 for the 9-month program NOTICE OF DISCLOSURE: Paid sponsorship *****SPECIAL THANKS to Jordan******   Go to PayPal.me/KetoTalk to make a donation.  You can set up automatic monthly payments there THE PERFECT KETO SUPPLEMENT USE COUPON CODE LLVLC FOR 15% OFF NOTICE OF DISCLOSURE: Paid sponsorship   KEY QUOTE: “Food comes first. I don't think you can supplement your way into an optimum, healthy, ketogenic diet.” — Dr. Will Cole MAKE KETO EASIER WITH FBOMB JIMMYLOVESFBOMB FOR 10% OFF YOUR FIRST FOOD ORDER NOTICE OF DISCLOSURE: Paid sponsorship Here’s what Jimmy and Will talked about in Episode 85: RESPONSE FROM A LISTENER: Hey, Jimmy and Dr. Cole, I listened to your discussion in Episode 81 of Keto Talk about the difficulty in getting life insurance and I wanted to let you know that there are actually carriers that will issue up to $1 million policies up to the best rating class without having to go through any blood/urine profile or physical exam. If they are healthy and between the ages of 18-54 and have not been declined or rated from a life insurance carrier before, this option is available. It could be a good fit for someone that thinks their blood levels may be "abnormal" from the insurance company perspective and want to avoid doing labs. Just an FYI for people to talk to their insurance broker about this. Thanks, Justin HOT TOPICS: Zero carb diets Exogenous ketones To Test or Not To Test For Ketones Join The Keto Clarity Club For $1 Blood Ketone Test Strips!   – That keto diet you think is working wonders could kill you – Furore over ketogenic diet – The Silicon Valley execs who don't eat for days: 'It's not dieting, it's biohacking' – Mick Jagger gets satisfaction from diet that could add 10 years to his life KEY QUOTE “If you're eating zero-carb, make sure you're eating nose to tail to ensure you are getting all the micronutrients you need.”  – Jimmy Moore – Why am I having painful leg cramps while on keto outside of electrolyte imbalance? How do you resolve them without supplementation? Hi, Jimmy and Dr. Cole, I love this podcast, been listening since Day 1. I’ve been eating low-carb for several years and about a year and a half ago I went full-on keto. I love this way of eating and have seen a lot of benefits from it. I regularly see average ketones of 1.7 mmol/L. However, there is one drawback I experience at least once a week and upwards of four times a week. It’s the dreaded leg cramps. They are more common at night, often when I’m sleeping, but I’ve experienced them pretty much anytime throughout the day. I believe the ketogenic lifestyle truly is the ideal way to eat, but I shouldn’t be having this major and often quite painful side effect, right? I’ve heard you discuss the issue of muscle cramps in the past and how they’re typically due to dehydration and/or electrolyte depletion or imbalance. The quandary I now have is how can I really consider this ketogenic diet to be “ideal” if it leaves me with this leg cramp issue that I seemingly have to solve with supplementation. Obviously, if this way of eating was being implemented by our ancestors and it was causing them this problem, they wouldn’t have been able to solve it with supplements. I don’t have any major health issues and am not metabolically broken. But this nagging problem with my ketogenic diet makes me wonder how it can truly be the perfect way to eat? Any ideas why my electrolytes may be out-of-whack and leading to leg cramps? Or could the cramps possibly be due to something else I’m not aware of? I appreciate your help. Keep up the good work! Brian   – STUDY: Red meat halves risk of depression 1. Why am I experiencing a sudden dip in my energy levels while eating ketogenic when energy has been great? Dear Jimmy and Will, I’ve been following the ketogenic diet for nearly a year at the age of 75 and have experienced great energy eating grass-fed meats, fresh farm eggs, and organic vegetables. But over the past month I’ve noticed my energy has taken a dive and I thought it might be the heat of the summer. But my blood pressure also dropped so low (70/42) that I had a tough time just standing up. My doctor had me wear a heart halter and discovered I have tachycardia. Of course, now I have to see a cardiologist and I’m sure he’s gonna flip out about my numbers eating keto: Total cholesterol 294, LDL-C 198, HDL-C 85, triglycerides 55, LDL-P 2100, small LDL-P 386, VLDL 11, fasting blood glucose 90, Vitamin D 97.0, C-Reactive Protein 1.1 Do you have any suggestions for me? Brenda   2. Is there concern about a low Vitamin C intake while eating a restricted ketogenic diet like the one outlined in The Plant Paradox? Hi, Jimmy and Dr. Cole, A friend of mine read the book The Plant Paradox by Dr. Steven Gundry and is following his dietary advice. After reviewing their recommendations (essentially no legumes, no grains, low/no fruit, no vegetables that contain seeds on the inside like cucumbers, squash, etc) it seems that she would easily fall into the ketogenic diet recommendations. She recently met with her naturopath who was leery of keto because of a supposedly low vitamin C intake. Do you have any insight into this and how a ketogenic dieter would get Vitamin C? I usually follow a Paleo/keto diet but have never considered micronutrient deficiencies as a concern because I am eating so much plant matter. Thank you in advance! Alexandria 3. How do I avoid the onslaught of sugar and crappy carbage while I am in the hospital? Will they honor my request to keep the sugar and carbs out of my diet? Hey guys, What is a patient who eats keto supposed to do when they are in the hospital? I need to have aortic heart valve and stem replacement surgery someday and I worry about what this hospital stay will do to me. I’m a severely insulin resistant Type 2 diabetic who had an A1c of 10.4 prior to going on a ketogenic diet. Three months after going keto, that number dropped to 5.6. I’m keto for life now, but this hospital stay will be a challenge to avoid the crappy carbage they like to serve as well as the sugar-filled goop they put in the feeding tubes. I already know my healing won’t happen properly with high blood sugar and insulin levels and the hospital will simply medicate and inject me with insulin to deal with it. If I asked my hospital to avoid doing this, will they follow my wishes? I suppose I could just fast the entire time I am in the hospital, but do you have any suggestions about this? Thanks so much for helping me with this. Ethan KETO TALK MAILBOX – Does a ketogenic diet help or hurt with anxiety issues? Hey Jimmy and Will, I just found and subscribed to Keto Talk—thank you for the great information! I’m thinking seriously about getting into the keto thing for myself, but I am doing my homework first. I am a 61-year-old carb addicted female who needs to lose at least 50 pounds. I was recently diagnosed as pre-diabetic and I want to get myself back to feeling happy and well again. My question for you guys revolves around how keto helps with anxiety issues. Is there any medical, scientific, or other data with ketogenic diets and anxiety? Or does it make anxiety worse (ugh…I hope not)? Thank you again! Kim iTunes reviews:   LINKS MENTIONED IN EPISODE 85 – SUPPORT OUR SPONSOR: Join Jimmy Moore’s Keto Support Group: KetoClarityAcademy.com – SUPPORT OUR SPONSOR: Join The Keto Clarity Club For $1 Blood Ketone Test Strips! BestKetoneTest.com – SUPPORT OUR SPONSOR: The world’s freshest and most flavorful artisanal olive oils. Get your $39 bottle for just $1. – SUPPORT OUR SPONSOR: Become A Nutritional Therapy Practitioner – SUPPORT OUR SPONSOR: Jump start your ketogenic diet with PerfectKeto.com/Jimmy (USE PROMO CODE LLVLC FOR 15% OFF) – SUPPORT OUR SPONSOR: Drop an FBOMB for the freshest, high-quality fats from JimmyLovesFBomb.com (Get 10% off your first food order with coupon code “JIMMYLOVESFBOMB”) – That keto diet you think is working wonders could kill you – Furore over ketogenic diet – The Silicon Valley execs who don't eat for days: 'It's not dieting, it's biohacking' – Mick Jagger gets satisfaction from diet that could add 10 years to his life – STUDY: Red meat halves risk of depression – Jimmy Moore from “Livin’ La Vida Low-Carb” – DR. Will Cole D.C. from DrWillCole.com – HELP KEEP KETO TALK ON THE AIR: MAKE A DONATION HERE

If you are interested in the low-carb, moderate protein, high-fat, ketogenic diet, then this is the podcast for you. We zero in exclusively on all the questions people have about how being in a state of nutritional ketosis and the effects it has on your health. There are a lot of myths about keto floating around out there and our two amazing cohosts are shooting them down one at a time. Keto Talk is cohosted by 10-year veteran health podcaster and international bestselling author Jimmy Moore from “Livin’ La Vida Low-Carb” and Pittsburgh, PA functional medicine practitioner Dr. Will Cole from DrWillCole.com who thoroughly share from their wealth of experience on the ketogenic lifestyle each and every Thursday. We love hearing from our fabulous Ketonian listeners with new questions–send an email to Jimmy at livinlowcarbman@charter.net. And if you’re not already subscribed to the podcast on iTunes and listened to the past episodes, then you can do that and leave a review HERE. Listen in today as Jimmy and Will chew the fat and answer your low-carb, high-fat, ketogenic questions in Episode 81. MAKE KETO EASIER WITH FBOMB JIMMYLOVESFBOMB FOR 10% OFF YOUR FIRST FOOD ORDER NOTICE OF DISCLOSURE: Paid sponsorship Go to PayPal.me/KetoTalk to make a donation.  You can set up automatic monthly payments there. Join The Keto Clarity Club For $1 Blood Ketone Test Strips! KEY QUOTE: “If you're not losing weight you have to look at the nonfood factors as well. Stess, sleep, and toxins are just as important for some people.” — Dr. Will Cole Here’s what Jimmy and Will talked about in Episode 81: HOT TOPICS: Fasting counting net carbs vs. total carbs conventional foods vs. grass-fed/organic foods – Action on Sugar accuses food companies of avoiding clear food labelling – 'I have a way to beat this thing.' – Meat snacks clock faster growth than potato chips: Mintel – Wendy’s Japan replaces bun with meat in new sandwich, touts its low-carb nutritional merits   – How does someone eating a ketogenic diet with elevated LDL-C and total cholesterol get good life insurance? Is there a company that looks at the relevant numbers? Hey guys, I’ve enjoyed listening to you and your new co-host Dr. Cole on Keto Talk the past couple of weeks. I’m looking forward to hearing a lot more from you two! I have a quick question for you guys to address that I think impacts a lot of us Ketonians: Is there a life insurance company that understands the new way to look at lipid panels and related lab markers that give more credence to things like HDL, triglycerides, hsCRP, lower small LDL-P, lower ApoB, and more? It seems most of these companies prevent an otherwise healthy person from obtaining proper levels of life insurance unless their LDL-C and total cholesterol are in line with conventional thinking which we know is an incomplete picture. Thanks for addressing this important topic! Moe ONESTOPKETO.COM IS YOUR GO-TO PLACE FOR KETO FOODS Use coupon code KETOTALK for special discount NOTICE OF DISCLOSURE: Paid sponsorship STUDY: Ketogenic Diets And Cancer: Emerging Evidence 1. Can the fat you eat on a ketogenic diet make hot flashes and swelling worse just like carbs do? Hey Jimmy and Will, I’m a regular listener to Keto Talk and love what you are doing here. My question for you guys is about whether the fat I’m eating on my ketogenic diet is making my hot flashes worse and my fingers swell. I’m 57 years old, weigh 130 pounds, and am addicted to sugar. But when I replace sugar with fat, all of these things seem to happen in my health. Is this normal? Maybe I need to cut my fat and red meat consumption and eat more vegetables. Do you guys think this is a good idea? Thanks so much, Rainny KEY QUOTE: “ If you're going to fast, begin with a ketogenic diet because keto will cause you to be satiated and fasting will happen naturally”  – Jimmy Moore 2. Is eating more vegetables on my ketogenic diet the answer to my adrenal fatigue that seems to be halting my weight loss progress? Dear Jimmy and Dr. Cole, I have been on a ketogenic lifestyle since May and have not lost a single pound. I keep my carbs below 20g and went to see a ketogenic-friendly physician since I thought I was perhaps eating too much fat. In doing more research into what I might be dealing with, I suspected adrenal fatigue that has led to exhaustion and lab tests have confirmed this to be true. My keto doctor requires me to eat a lot more vegetables in my diet, but now I’m hungry again despite showing 1.0 mmol in my blood ketones. I’m a bit frustrated right now about what’s going on with me because I should be losing weight, right? Thanks for helping to point me in the right direction. Becky GET A $39 BOTTLE OF OLIVE OIL FOR JUST A BUCK GET YOUR $39 BOTTLE FOR JUST $1 NOTICE OF DISCLOSURE: Paid sponsorship 3. What natural pain remedies can be used by Ketonians who would rather not take medications? Hey Jimmy and Will, I’ve been experiencing an increase in pain in my shoulders, elbows, and knees since I went keto two months ago. I’m a 62-year old male who was diagnosed with hypothyroidism four years ago by an allopathic doctor and prescribed Synthroid. I never liked the side effects of that medication, so I switched over to iodine supplements to go more natural in my treatment of this. Keto has given me great energy, no more food cravings, and has zapped out my hunger allowing me to intermittent fast for 16 hours daily. I lost 45 pounds on a traditional diet before going ketogenic and have lost another 30 pounds in the two months I’ve been keto. My goal is another 100 pounds, but I need something natural to give me pain relief while I’m on this journey. Shalom, George JIMMY AND DR. ADAM NALLY’S KETO LIVING SUPPLEMENTS   KETO TALK MAILBOX – Is it normal to be sick of the dietary fat you consume on a ketogenic diet by day four of eating this way? Hey guys, I was wondering if it is normal to get sick of eating dietary fat after three days of eating keto. I absolutely love it for the first three days eating high-fat foods, but then something happens by day four when I can’t even think of eating another ketogenic meal. Is this normal and will I get over this? I really want to do this diet because of all of the health benefits and maybe lose a few pounds. But I need to know if I just need to push through the feeling I’m getting and get to the point where I will enjoy keto meals on a regular basis. Thank you for your help, Michele THE PERFECT KETO SUPPLEMENT USE COUPON CODE LLVLC FOR 15% OFF NOTICE OF DISCLOSURE: Paid sponsorship iTunes review:   LINKS MENTIONED IN EPISODE 81 – SUPPORT OUR SPONSOR: The Ketogenic Bible – SUPPORT OUR SPONSOR: Join Jimmy Moore’s Keto Support Group: KetoClarityAcademy.com – SUPPORT OUR SPONSOR: Join The Keto Clarity Club For $1 Blood Ketone Test Strips! BestKetoneTest.com – SUPPORT OUR SPONSOR: The world’s freshest and most flavorful artisanal olive oils. Get your $39 bottle for just $1. – JIMMY AND ADAM’S NEW SUPPLEMENT LINE: Try the KetoEssentials Multivitamin and Berberine Plus ketogenic-enhancing supplements – SUPPORT OUR SPONSOR: Jump start your ketogenic diet with PerfectKeto.com/Jimmy (USE PROMO CODE LLVLC FOR 15% OFF) – SUPPORT OUR SPONSOR: Drop an FBOMB for the freshest, high-quality fats from JimmyLovesFBomb.com (Get 10% off your first food order with coupon code “JIMMYLOVESFBOMB”) – SUPPORT OUR SPONSOR: Get a full selection of ketogenic-friendly foods at OneStopKeto.com (FREE SHIPPING on orders over $99 and use coupon code KETOTALK for a special discount) – Action on Sugar accuses food companies of avoiding clear food labelling – 'I have a way to beat this thing.' – Meat snacks clock faster growth than potato chips: Mintel – Wendy’s Japan replaces bun with meat in new sandwich, touts its low-carb nutritional merits – STUDY: Ketogenic Diets And Cancer: Emerging Evidence – Jimmy Moore from “Livin’ La Vida Low-Carb” – DR. Will Cole D.C. from DrWillCole.com – HELP KEEP KETO TALK ON THE AIR: MAKE A DONATION HERE

Adam Zickerman discusses his 90-day journey of religiously dedicating himself to following a ketogenic diet here in Episode 25 of the InForm Fitness Podcast.  Adam reveals the challenges of sticking to the ketogenic diet along with some misconceptions and the dramatic results.Here is a link to the website Adam mentions in this episode:  http://eatingacademy.com/nutrition/ketosis-advantaged-or-misunderstood-state-part-i Don't forget Adam's Zickerman's book, Power of 10: The Once-a-Week Slow Motion Fitness Revolution.  You can buy it in Amazon by  clicking here: http://bit.ly/ThePowerofTenTo find an Inform Fitness location nearest you to give this workout a try, please visit www.InformFitness.com.  At the time of this recording we have locations in Manhattan, Port Washington, Denville, Burbank, Boulder, Leesburg and Reston.If you'd like to ask Adam, Mike or Sheila a question or have a comment regarding the Power of 10. Send us an email or record a voice memo on your phone and send it to podcast@informfitness.com. Join Inform Nation and call the show with a comment or question.  The number is 888-983-5020, Ext. 3. For information regarding the production of your own podcast just like The Inform Fitness Podcast, please email Tim Edwards at tim@InBoundPodcasting.comThe transcript to the entire episode is below: Adam: You know when you're wearing clothes, my lean muscular build, it's hard to know that I was getting a little bit of a spare tire underneath them, but I was getting a little bit of a spare tire, but besides that, there were two things. One, my chronic back problems which you covered last episode, and I wanted to do whatever I could to ameliorate these back issues. Consistent and safe back exercises are one of them, and the other thought I had was maybe my diet is affecting my back, because I was reading a lot about the typical American diet and it's inflammatory. I'm thinking I might have an inflammation issue going, my back keeps going into spasm, it's probably chronically inflamed. If I can not only exercise my back properly but maybe reduce my chronic inflammation, that might be my answer. Tim: InForm Nation, welcome to episode 25 of the InForm Fitness podcast. Twenty minutes with New York Times bestselling author, Adam Zickerman and friends. I'm Tim Edwards with the InBound Podcasting Network and a client of InForm Fitness. Joined as always by Sheila Melody, Mike Rogers, and of course Adam Zickerman. Okay team, at the time of this recording, spring has just sprung, summer is just a few months away, and I'm sure a good portion of InForm nation is already thinking about summer which means they're thinking about slimming down a little or in some cases a lot, so dieting is on their minds. We've all heard of, and I'm sure participated, in at least a few nutrition plans, like the paleo diet, the Atkin's diet, or the one that I really enjoyed a few years ago was the slow carb diet from Tim Ferris. Most recently I had tremendous success by just eating cleanly as you describe Adam in chapter three of your book, Power of Ten: The Slow Motion Fitness Revolution.So Adam, you visited LA. just a few months ago when we recorded the Adam in LaLa Land episode and frankly, you looked extremely fit. So in the last episode, you mentioned that we're going to talk about a diet that you've been on for the last X amount of days, and my question is why did you even consider going on a diet in the first place because you don't look like you need to go on one.Adam: I picked up a few lessons from my female friends and I know how to dress to hide it.Tim: You wear Spanx, that's what you're telling me?Mike: Spanx and New York black. Everyone in New York knows how to hide it.Adam: Hide our emotions.Tim: You don't hide your emotions in New York, come on.Adam: The people in L.A want to hide their emotions.Tim: We're the passive aggressive ones.Sheila: Oh no, we want to talk about our emotions.Tim: That's down in the south where they're passive aggressive, but anyway, we digress. You mentioned the diet, and here's a guy, the guru, the InForm Fitness and you're fit. So what prompted you to go on a diet?Adam: I'm so glad you asked me that question, because you know the other question I get asked in a similar vein is why do you work out Adam, you look great. Sheila: You say because I never want to look like you.Adam: That just reminded me of something Yogi Bear once said. Nobody goes to that restaurant anymore, it's always too crowded. So listen, why did I go on this diet. Well first of all, diets are not always about weight loss, fat loss. Diets are about health, or they should be. Now I know that anyone who goes on a diet, their number one concern is I want to lose body fat, which is a noble goal because being overweight has health problems associated with it. Now I did want to lose a little weight first of all, because I always said that I hide it well half-jokingly, because the other half, I did need to lose a couple of pounds and it is true that when you're wearing clothes, my lean muscular build, it's hard to know that I was getting a little bit of a spare tire underneath them, but I was getting a little bit of a spare tire, but besides that, there were two things. One, my chronic back problems which you covered last episode, and I wanted to do whatever I could to ameliorate these back issues. Consistent and safe back exercises are one of them, and the other thought I had was maybe my diet is affecting my back, because I was reading a lot about the typical American diet and it's inflammatory. I'm thinking I might have an inflammation issue going, my back keeps going into spasm, it's probably chronically inflamed. If I can not only exercise my back properly but maybe reduce my chronic inflammation, that might be my answer. So for years, I've been reading about the ketogenic diet, and for years I was poo-pooing it.Tim: Why?Adam: Because I had a vast misunderstanding about what a ketogenic diet was. Basically using ketones for fuel. I'll get into what a ketone is a little bit later, but my understanding of ketones was when your body is using ketones for fuel, or if you're producing a lot of ketones, I always understood that to be very dangerous. In my mind without realizing it, I was really thinking about what they call ketoacidosis, which is much different than nutritional ketosis, using ketones for fuel from a nutritional point of view, as opposed to something very dangerous called ketoacidosis. That was where the confusion comes in. Whenever you talk to a doctor or a nutritionist and say I want to go into ketosis, they say it's dangerous, and being in ketoacidosis is very dangerous but you cannot go into ketoacidosis just by eliminating carbohydrates or going to what they call nutritional ketosis. Ketoacidosis, let me explain what that it is. It usually afflicts people with Type I diabetes. Type I diabetics cannot produce insulin, and when you cannot produce insulin, when you eat carbohydrates, the sugar starts building up and building up, and what happens is the body can't utilize that sugar, because the insulin is not there to use that sugar and bring it into the fat cells and the muscle cells, or bring it into any cell that needs that for energy. So the body, if it can't get glucose for energy, it starts metabolizing fat for fuel. That's where it's going to get it's energy from, and it starts going crazy producing these ketones. You see ketones come from fat, the metabolism of fat. An alternative sense of energy for the body are ketones, fat gets broken down into ketones, carbohydrates get broken down into glucose and when the body breaks down carbohydrates for glucose and those glucose molecules can't be used, the body will say okay, let me go break down some body fat, get some ketones out of it, and utilize that for fuel. So it's another source of currency if you will, and if you're a Type I diabetic, your body goes crazy producing these ketones and you end up having so many ketones that you go into an acidic state, a dangerously acidic state where basically all functions of the body cannot produce and cannot function when you're in such a high acidic state. In other words, we have to have a pH level that's very, very stable, like about normal, about 7. Our pH is about 7, that's the normal functioning pH of the human body. When you start having all these ketones that start going through the roof — ketones are acidic by the way, and ketones that are not being checked or regulated, start going through the roof and you are in a very dangerous state. So a Type I diabetic can very often go into ketoacidosis and they have to go the hospital, they have to get the injections, and usually it's a diabetic that's not taking care of themselves. You cannot go into that acidic state being in what I have been in the last ninety days which is called nutritional ketosis. Nutritional ketosis is a state in where you body instead of using glucose for fuel, not because there's no insulin, but because you're not eating anything that's going to produce a lot of glucose, your body says well I need energy, so I'm going to start using fat for fuel. Every cell cannot use actual fat for energy, they have to break down the fat. Just like we have break down carbohydrates for glucose, we have to break down fat, and we're breaking them down into fat and these ketone bodies are being used for fuel. Well there's a lot of evidence right now that's showing that these ketogenic diets which are to break it down into macronutrients about 70-75% fat, about 10% protein, maybe 15% protein, and then the rest which is about 5% carbohydrates.Tim: Now immediately, red flags are flying all over when you say the diet is made up of 75%  fat. Now let's drill down on that a little bit more. We're not talking cheeseburgers.Adam: Well we're not talking cheeseburgers with the bread, but we are talking cheeseburgers. I will have red meat, I will have cheese. Red meat has to be grass fed, not this factory raised cow. So the quality of the foods that you're eating is also very important, so I eat grass fed beef and beef, the fat in the beef is very good for you. What you have to be careful of, this is what I realized and this is a very common mistake that people make on ketogenic diets, that they think it's a high fat, high protein diet, but it's not really high protein. Having too much protein can actually produce an insulin response or produce sugar, because protein can be converted into glucose, it's called gluconeogenesis, and it can be almost as bad as actually eating carbohydrates. A lot of people will eliminate their carbohydrates and they'll end up having tons of red meat, which is a lot of protein.Tim: That sounds like the Atkin's diet to me.Sheila: That's what I was just going to say.Adam: The Atkin's diet, in essence, a ketogenic diet and the misinterpretation of the Atkin's diet of a ketogenic diet is that the image is like a bunch of caveman sitting around gnawing on a dead animal or something like that and just eating fat and bacon and protein all day long. It's not like that, it's mostly vegetables that are saturated in fat like olive oil, or coconut oil or avocado oil. Salads that are doused in that kind of fat, so getting vegetables or other types of oils and avocados in general, grass fed meat, pasture raised chickens, eggs, and of course wild fish. That is my diet, and it's not like I'm eating tons of meat. I'm eating six ounces of a steak, I'm eating tons of brussel sprouts that have been roasted in coconut oil.Tim: All sounds good to me so far.Sheila: Probably 85% of the time I eat exactly what you just described.Adam: I committed to eating this way without exception for ninety days. I started at the beginning of this year.  Here we are. Tim: Where are you now at the time of this recording?Adam: It's a coincidence but I am literally, today, on my 90th day. It started January 3rd, which is a Tuesday. So I don't know if it's the 90th day, but I just finished my twelfth week starting January 3 and this is a Tuesday. So today is the last day of my twelfth week.Mike: I don't think 90 is divisible by seven.Tim: Well he's close.Mike: I've got my advocates in the corner there.Tim: So nonetheless, let's review.Adam: By the way, at the beginning I said why I did this. I thought it'd help my back, anti inflammatory. Ketogenic diets are well suspected to be anti-inflammatory. The second reason why I wanted to do this diet was because I had my annual checkup and I'm in my early 50s now, but 50s nonetheless, and my blood work is creeping the wrong way. They're starting to get on the high side of normal.Tim: Let me ask you, is that prior to going on the diet?Adam: Prior to going on the diet, I had my annual checkup and the results came in and he said to me hey, nothing to be alarmed about at this point but you're trending the wrong way. You're C-reactive protein is creeping which is an inflammatory marker, and he said your cholesterol is creeping up, it's not too high per se but it's on the higher side of normal. My A1C which is an indicator of your blood sugar was creeping up again on a high side of normal. I was like wow. These are all things that indicate that I'm going towards what many Americans go towards which is metabolic syndrome. It reminded me the same situation that Dr. Peter Attia, his story when he started his quest on ketogenic diets, and he was in the same situation. He worked out all the time, he thought he ate well most of the time. We think eating well is eating whole grain breads, and fruits, and occasionally what's so bad about having a beer here and there, and next thing you know, in a day you're still ingesting 250 grams of carbohydrates without even thinking about it. So he started taking control of it as well, and when I saw that my blood numbers were going up and then I read what Dr. Attia went through as well, I was like holy cow that's me. So that also prompted me, I wanted to see if going on a ketogenic diet would change these numbers. Well this is the 90th day so I'm about to get those numbers checked, so I'm going to report back on this but when I can talk about now is how I feel. Tim: Let's start with your back.Adam: And what has happened. First of all my back, in combination with what I've been doing with my lower back exercises and staying consistent with that, my back has never felt better. I can sit for hours in a car, or I can sit for hours at my desk, and get up sideways.Tim: And you're giving this ketogenic diet credit for assisting with that.Adam: First of all, I'm a sample size of one, so this is scientific at all, but I am giving it credit. That in conjunction with taking care of my back with the exercises. So I don't know where the cause and effect is because I've been doing a couple of things at once, but the big teller is going to be obviously the blood work that I get done soon. Besides that and besides the fact that my back feels better, I've lost fifteen pounds of weight that you didn't think that I needed to lose. So I look a lot better naked now, so I don't have to wear clothes anymore. I don't have to wear a T-Shirt to the pool anymore.Mike: You know when your body gets a little bit smaller, it gives the illusion that other things are bigger.Adam: You have that as well. Big thing that I noticed was my digestion. My digestion changed dramatically. I don't have upset stomach, my elimination if you know what I'm talking about has been undramatic, it's been beautiful.Sheila: It's a beautiful thing.Tim: Well your good friend Dr. Oz would be proud of that.Mike: Maybe this will get edited out, maybe it won't, but I'm just curious. What does beautiful mean? Tim: That actually is so it will not be edited out, so describe beautiful? You mean like one clean long — Adam: Exactly, tapered on both ends, perfect.Tim: Dr. Oz was his thing right?Adam: It's embarrassing, especially since you're talking about me.Mike: You don't sound like you're embarrassed.Adam: I am. You've got to remember that this is someone who is too shy to urinate in front of his wife. Mike: I'm going to remind you that you're the one who is talking about himself right now. Tim: So nonetheless there's a lot of fiber in this diet and it's really helping Adam a lot, so good.Sheila: That's really, really very interesting and I want to ask a question about is there a difference in how women react to this diet as opposed to how men react to this diet? Coming off that interview we had a few weeks ago with Dr. Sylvia Tera and The Secret Life of Fat, and how different men and womens' makeup is and how we process fat and everything. It sounds like something I'd like to try, and I feel like I've been kind of doing this for the most part.Tim: I think she's committing, I think she should jump on 90 days.Adam: I'm not sitting here saying everyone should jump on the ketogenic diet bandwagon first of all. I need to make that disclaimer. First of all, women are different and we're all different. I'm different from another man, and women certainly have their issues. When you talk about nutrient partitioning and that no matter what you eat, some of it is going to be partitioned to fat. Hormonal issues with women as they get older, all kinds of things. Genetics for men and women are different amongst ourselves and all these things play into it for sure, but having said that, sugar is bad. Sugar is bad, sugar is inflammatory. There is nothing good that comes out of sugar and excessive carbohydrates. I don't believe being in ketosis is dangerous anymore, and this idea of eating a lot of fat, even if it's saturated fat, especially if it's saturated fat, is not bad for you. It's been shown over and over again that dietary fat does not raise your cholesterol, so just check that box off. It's not true, it is just not true that eating egg yolks and eating red meat raises your cholesterol, that is not what is raising your cholesterol. The last ten, fifteen years have been really showing that. My blood work will show this, if I go to my blood work and my cholesterol is through the roof I'm going to have to eat my words. It might even be another cause of it, but the thing is if all my triglycerides are good and inflammatory makers are lowered and my cholesterol happens to stay on a higher side, and everything else is really, really good, I'm not going to worry about high cholesterol. High cholesterol, high LDLs are not a very good marker on heart disease.Mike: On its own.Adam: On its own. Now there's this other test that Dr. Attia actually told me to get which is an NMR, nuclear magnetic resonance test, to test for your LDLP. See when you go to the doctor and you get your cholesterol and blood work done, you're getting blood work for your LDLC. LDLC is how much cholesterol, low density cholesterol is in your blood, whereas the LDLP is showing you how many LDL proteins are in your blood. I'm getting technical right now, but it's a different marker and a much better marker and indicator of potential heart disease, this LDLP. So I'm going to get that done, and see if my LDLP is nice and low, and if that is, regardless of what my LDLC is or total cholesterol is, I'm not going to be worrying about it. Again, my A1C, my C reactive protein, these markers, if they stat going down after ninety days of eating, I'm not kidding you, 70% of my diet being fat, I'll be pretty convinced. At least for myself. Let me tell you about my experience psychologically.Tim: I'm curious how you managed this, because it seemed like a lot of drastic changes.Adam: This is why I'm not necessarily telling people to just go on this ketogenic diet. First of all, I'm not a nutritionist, I just play one on TV. So I'm a nutritionist, secondly, I'm not going to lie, it's not easy to adjust to this type of diet. If you're used to eating grains and carbohydrates — I'm essentially a vegetarian that is saturating their vegetables with saturated fat and all kinds of fats, and having small portions of animal protein, whether it be a chicken or a fish or a cow, all well raised, but they're small quantities. I'm not eating a lot. I'm also intermittent fasting. I'll go at least two or three times a week, I'll go anywhere from eighteen to twenty four hours without eating. I'll be drinking lots of liquids, I'll be drinking homemade beef broth or chicken broth, and that's it. So that's all I eat, one meal all day.Tim: So tell us your schedule Adam. So with this intermittent fasting, what time are you stopping eating at the end of the day?Adam: I'll eat dinner.Tim: At what time?Adam: Anywhere between five and seven most days. So let's say I finish eating seven. I won't eat again until at least two or three o'clock the next day. On some cases I won't eat again until dinner the next day.Mike: When you work as much as we do, I've got to be honest with you, time flies and you sometimes forget about food. I'm not as strict as Adam is, but I'm probably doing about 85% or 90% of what he is doing in regards to the ketogenic model, and the fasting model without even trying to.Adam: We work a lot and that speaks to one of the techniques that people recommend to help you through these intermittent fasts and that's distraction techniques. So when your mind keeps saying eat, eat, eat, distract yourself, pick up your guitar, write a letter, do something else. Distract yourself. A lot of this hunger by the way, is psychological, we're just not used to it mentally, but besides that, at the beginning, your body is physically wanting that food but once you start utilizing your fat for fuel and you become what they call keto-adapted where your body is primed to really use fat for fuel, and that takes a couple of weeks. Three weeks, four weeks sometimes. The first there or four weeks was the toughest because I was not adapted yet, so I was very hungry. Now, well it's 4:30 and I haven't eaten yet today. Last time I ate was dinner time around five yesterday.Mike: That's a lie, he had two celery sticks from me.Adam: That's true, it's two celery sticks so I broke my fast. Honestly I grabbed them because they were there, it was not because I was dying to eat something, and if I was dying to eat something, I certainly wouldn't have picked that.Sheila: When you say you're fasting, so you mentioned the broth though. So you have that when you're fasting, or you just have nothing, you have water.Adam: I have water mostly, but yeah, we serve bone broth here, we're making our own bone broth now. We can talk about that at a later date, but yeah, that doesn't count as cheating. It's 99.9% water, it just has the minerals and the amino acids in it. So I don't consider that really cheating, but come on. Even if I was to have a small meal, the gist of it is going long periods of time without eating, and that from my understanding is the real anti-inflammatory aspect. I mean sugar causes inflammation, and eating a lot also causes inflammation because you're breaking down all this stuff and getting all these free radicals and all this oxidative work going on, and that's what causes a lot of the inflammation. Now I'm reading and I'm learning that intermittent fasting forces the body to regenerate its cells at a lot faster of a rate. There's something to that.Sheila: I also read that an easier way to do the intermittent — well, for a sixteen hour fast that you can basically do is just stop eating at seven, and then don't eat again until eleven AM. That's sixteen hours.Adam: Basically skipping breakfast.Tim: A lot of people do that anyway.Adam: But this is the problem with intermittent fasting. When I go 24 hours, I'm hungry by then. A lot of people say they can go days without eating and these are people that are really and truly keto-adapted, maybe they've been doing it for a year or more. I don't know, but so far, I haven't been able to go more than seventeen hours without all of a sudden having all those hunger pains, and at that point I just deal with it for another few hours. At that point, when I do eat, this is the hard part. You have to eat a regular, small meal. Tim: No binging.Adam: It's so easy when you're famished like that and you've gone all day without eating, it's like you want to eat lunch, breakfast, dinner, and snacks all at one time in one sitting. You have to stop yourself from doing that.Mike: That's probably one of the differences to what was going on even before you did this 90-day thing. Our lifestyle really lent itself to — none of us eat that many carbohydrates ever. Adam hasn't for a while, but when you were, you probably — I'm just guessing because you're like me, I do these all day fasts also. If I don't have some snacks or prepare my food throughout the day as I did this week, I will come home and I will eat like seven pieces of chicken and I'm not proud of it afterwards. Unless you can control that voracious urge, you're not going to get what Adam is talking about here.Tim: So Adam, as we come to end of this episode, I really would love you to encourage you to get those tests done quickly, and if you don't mind, share some of them with our audience so that we can gauge your success. The question that I have for you right now as we put the wraps on this is okay, we're close to or at day 90. Are you going to continue and forge ahead with the exact same plan that you've had for the last three months or so, are you going to augment it a little bit, what are your plans?Adam: I'm going to continue, I'm going to stay on this. I might eat a little bit more often at this point, because I don't really need to lose anymore body fat. I've got the six pack going for the summer, that's all good.Tim: Look at you, he's in his 50s and he has a six pack, that's impressive.Sheila: Do you drink coffee, can I ask that?Adam: I drink coffee. Let me speak to something Mike just said. He was saying that we're generally very good about not eating carbs, and that's partially true, with me anyway. What I mean by that is I have two young kids and I grab the M&Ms. My wife buys five-pound bags of them so she can make pancakes for the kids. Don't get me started, my wife will not let me put my kids on a ketogenic diet.Mike: My wife is a nutritionist and she would never let it happen either.Adam: Because they're afraid of ketoacidosis, but anyway what I wanted to say was this. My diet before I started this, yes, I'd go three or four days really good, and then I'll eat a whole pizza. I would never really string along many consistent weeks or days. I'd eat well one day, not very much the other day, summers come, barbecue, hotdogs, hamburgers, I just went for it. I can get away with it. You said at the beginning of this piece, Adam you don't look like you need to lose weight, why'd you start this diet? I was creeping up, and even though it appears that I eat very well, and I obviously eat well most of the time. I certainly eat good foods but I also supplement them with not such good stuff. This last 90 days, I made a commitment not to deviate from that, to be really consistent with it. Yes it's higher fat than I would normally do when I did eat well. Less protein than I would normally — that's what I learned about a ketogenic diet, that most people make the primary mistake of eating too much protein on a ketogenic diet, and so this has been the first time in my life that I've been this disciplined in my eating. I'm older now, I can't get away with what I used to get away with. The other thing that I want to say before we wrap this up is about cravings. I always hear about how you go on these low carb diets and when your body starts getting used to and primed for utilizing fat for fuel, they say you eliminate all your cravings. Bullshit. To me anyway. Maybe the physical cravings aren't there and I told you I could go all day and not really be hungry, but the truth of the matter is, I'm craving the foods that I've been giving up nonstop. To this day, 90 days into it give or take, I still crave the pizza. I still see my kids eating the pizza, I still see the buns on the hamburgers and I want it, I want it bad. I say no, the cravings are there. Maybe the physical cravings aren't there as much.Tim: What do you mean by physical cravings, define that.Adam: My stomach growling and saying man you're hungry, you've got to eat. Or feeling a little lightheaded, or physically feeling the effects of hunger. Now that I'm keto-adapted I don't have those physical — when I'm 24 hours in I start to feel them, but eighteen hours fasts, it's a no-brainer for me, it's as easy as it could be. Even though those physical things aren't there, I pass a pizza place, I pass chicken wings at the Superbowl, hot dogs at the baseball game. Beer, alcohol, I want it all, those cravings have not subsidized. I don't look at them and say ew. I want it badly, but I don't do it.Sheila: It's easier to not do it.Adam: So going forward, I'm going to continue my strict ketogenic diet for at least another 30 days. I might eat a little bit more food, but not the foods I'm not supposed to be having on a ketogenic diet. The foods I can have, add a little bit to my portions, but that's the extent of it for the next thirty days. By that point, I'll have my blood work done and we'll talk about this some more.Mike: I just think before we wrap up, I think blood tests aside, that's data that we all need. It's great to get all that stuff, but the bottom line is you've taken an educated approach to selfexperimentation and troubleshooting your body to figure out how to improve it, and your back has felt better. Do we know it's because of the ketogenic diet, maybe it did, maybe it didn't, but regardless you're in a trend where you feel so much better. Your body feels better, your back feels better. You like the way you look, you feel, it's like I almost want to say — if the tests are completely negative or there's no improvement or any markers have been changed, who cares. Looking at someone who looks healthy also. They say that they feel great but they don't look healthy, but this is not the case.Adam: Like vegans. First of all, I want to say that this is not a ringing endorsement or a push for people to go ketogenic. I'm not going to be that bull at this point to say something like that. It's definitely a viable option, and before you go into something like this, check with your doctor and do a lot of research, because compared to the recommendations by the ADA, the American Diet Association, this is not what's recommended. I want to make this disclaimer. Look into it for sure, do your research. If it sounds like you, if I sounded like you, definitely look into it. Like Mike just said, I'm very well researched. I have a background in biochemistry, I know how to read these things. I'm a little bit different than your average bear when it comes to this type of thing. If you're not in that world, you should get advice when you do something like this.Sheila: Can you give us a starting point?Adam: Yeah, I do, I recommend the doctor that I mentioned earlier. Dr. Peter Attia, and his website is called the eating academy. Read everything this guy writes, and he also refers you to other things he reads so that is a great start. The eating academy by Dr. Peter Attia. So if you're interested in possibly doing this for yourself, well pay attention to our podcast, we're going to be reporting back on this in a little while when I get my blood work back and we'll take it from there. Good luck.Tim: Okay. So don't forget to check out the show notes for a link to the website that Adam referenced, spotlighting the research done by Dr. Peter Attia. That's eatingacademy.com. Looking forward to the results of Adam's blood work to gauge the success of his three-month ketogenic dietary journey, and we should have that for you coming up in the next few weeks. Also on the way, we have a couple of interviews that we're really excited about here at the InForm Fitness Podcast. In two weeks, we'll be speaking with happiness expert, Gretchen Rubin. Gretchen has authored several books and has sold more than two million copies in thirty different languages. She has been a client of InForm Fitness for many years, and she has a popular podcast of her own, titled Happier with Gretchen Rubin. So give it a listen and even subscribe to her podcast so you can become more familiar with Gretchen before she joins us here on the show, and in the process, pick up some valuable tips on being, well, happier. Next week, we'll be talking to Dr. Martin Gaballa, the author of the One Minute Workout. Adam and Dr. Gaballa will contrast and compare high-intensity strength training like we do here at InForm Fitness, and high-intensity interval training, as described in Dr. Gaballa's book, The One Minute Workout. If you'd like to find an InForm Fitness location nearest you so you can give this high-intensity strength training workout a try for yourself, please visit informfitness.com and at the time of this recording, we have locations in Manhattan, Port Washington, Danville, Burbank, Boulder, Leesburg, and in Restin. If you aren't near an InForm Fitness location, you can always pick up Adam's book via Amazon: Power of Ten, The Once a Week Slow Motion Fitness Revolution. Included in the book are several exercises that support this protocol that you canIf you aren't near an InForm Fitness location, you can always pick up Adam's book via Amazon: Power of Ten, The Once a Week Slow Motion Fitness Revolution. Included in the book are several exercises that support this protocol that you can actually perform on your own at a gym nearest you. We'll have a link to Adam's book in the show notes as well. Thanks again for listening, and for Sheila Melody, Mike Rogers, and Adam Zickerman of InForm Fitness, I'm Tim Edwards with the InBound Podcasting Network.Thanks again for listening, and for Sheila Melody, Mike Rogers, and Adam Zickerman of InForm Fitness, I'm Tim Edwards with the InBound Podcasting Network.

I hope you're enjoying this weekend and that you got to tune into yesterday's Cabral #HouseCall! We're back today with another 8 community questions, so let's get started! Lisa: Hi Dr. Cabral, Thank you so much for answering my questions on your podcast! You are one of a kind and we are all blessed by your time and knowledge you put into your podcasts! My question is, for years when I lay down I would suddenly hear noises. For me it was rock-n-roll music. I could hear words and it was ALWAYS the same song. I personally have NEVER listened to rock-n-roll before and Im pretty confident the song I heard was never an actual song on a radio before. It use to drive me crazy and again, it was only when I laid down. This lasted for at least 8 years but it suddenly stopped. My 9 year old daughter has the same problem but for her its not music, rather it's just beeping, clicking noises she hears when laying down. I feel bad for her because it truly bothers her. Have you ever came across people who only hear noises when laying down? And do you know the root problem? You may need to know that my daughter did have a history or Tourettes and OCD, however, since she has been on a special diet and gut healthy supplements, she no longer has those problems. Thank you so much! -Lisa   Karen: I heard about your podcast at a Weight Watcher meeting two months ago and have been listening ever since. Thank you for sharing your wealth of knowledge and especially, your Monday Mindset thoughts. I am 53 and recently had decided to see a cardiologist to have baseline heart checkup since my parents both died of heart disease at 60 and 61 and my sister(54) had a major stroke last year. (All three were diabetics who did not believe they were diabetics and did not routinely take meds or change lifestyle.) Anyway, my bp is good, glucose is 82, overall Cholesterol is 184, but the ratios are out of sorts with higher triglycerides and HDL. The main question is my LDL-P is elevated and is there a natural way of lowering it? I understand that this sub-particle test is a more accurate indicator of problems down the road. My lpa-2 is within normal range. The doctor or PA in this case, never discussed diet, lifestyle.....just immediately wrote a prescription for a statin and even called it in without asking me what I would like to do. I haven't picked the statin up and am hoping that there is a more natural way. If anyone would know, I trust it is you. Thank you so much.   Norman: Dr. I have cervical spondylosis and a kidney problem, can u please help me to cure or prevent this health problem of mine? Thank You very much, and more power!!   Ceri: Hi Dr Cabral. I've recently started following you on Instagram and have been listening to your podcasts ever since. They are hugely informative and helpful, thank you for sharing and passing your knowledge onto others. I have been having gut issues and diarrhoea for the past 20years. I have spent multiple trips to the doctor trying to find out what is wrong with only being told I have IBS. I recently found out I have a parasite, Dientamoeba Fragilis. My Gasteroenterologist wants to put me on a 10day course of antibiotics “Secnidazole” and “Doxycyline” I have heard mixed results and am unsure what to do. I have changed my diet over the years and now eat a whole food diet consisting of predominantly vegetables, moderate protein, lots of healthy fats and some fruit, mainly berries. This has helped with my gut issues but obviously they have not fully resolved. I don't want to ruin all my hard work in getting my health on track by taking the antibiotics. What do you recommend from your experience? Thank you in advance, Kind Regards, Ceri   Anon: Hi Dr. Cabral! I've been listening since last year, and I've learned so much along the way, so thank you! I have been a nutritional health coach for a while, and realized this has been fun because people themselves want to become healthier. I've been struggling with the people closest to me. For example, I have a friend put on anti-depressants for headaches, a friend with gut issues that affects her quality of life but won't change her diet for more than a couple days, and a baby cousin with really bad sinus issues only after she's fed her multiple bottles of cows milk. I never say anything because it's not my place, but also because no one likes a know-it-all. It just kills me because I want them to be happy, and feel like they could benefit from alternative options. I was curious to see what you would do in these types of situations. Thank you in advance :)   Angie: Hi Dr. Cabral, I check my basal body temperature every day, and it has been very low for years (96.8, sometimes lower) and I have a very hard time raising it, even throughout the day. I have had a full panel thyroid test done, which came back "fine" even though I struggle with many low thyroid symptoms. How can I raise my BBT and help my thyroid work properly again? Thanks for all of your help today and always.   Isabelle: Hi! Thanks for everything that you do, you guys are great! Do you have any recommendation for healing panic attacks yourself (and the general anxiety for having another panic attack), or do you consider therapy to be the best way to treat it? I have developed a fear of driving (as well as just being a passenger in a car) due to several separate panic attacks I had while being a passenger for about 3 years ago. I do think it is connected with the claustrophobia I have had for years, because it seems to get pretty bad when the car is very small, or when I drive on a highway where there is little -or no- chance of "getting out". It has only gotten worse over the past 3 years, and it has now come to the point where I avoid cars for all costs. This is so painful for me (as I used to literally love driving), and not to mention inhibiting and exhausting, as I now make up just about any excuse not to get in a car. If there is anything you know that could help, I would be forever grateful! Keep up the great work. Additional information: *I don't have my own car at the moment, so it is difficult to "practice" driving a car. *I live and work in the city, so I don't really have to drive anywhere, which make it easy for me to avoid driving in everyday life. Have a great day!   Lisa: Hi Dr. Cabral, I listen to all of your podcast and you truly amaze me with your knowledge. I have a question for a friend who is desperate to help their daughter. 3 years ago their daughter had a soccer injury in her ankle.... although her ankle has healed, something happen to her body and she has pain everywhere. The videos of her are so horrible to watch and Im praying you have some insight on her condition. The doctors say she has CRPS, Complex Regional Pain Syndrome....formerly called RSD. Can you help guide us to the root problem and I will pass on your podcast to the family? The doctors currently have tried everything and have no more ideas as to how to help her. Thank you again for being such a blessing to so many people! May God bless you and your family. I hope you enjoyed today's Q&A and all the tips added along the way! - - - Show Notes: http://StephenCabral.com/443 - - - Get Your Question Answered: http://StephenCabral.com/askcabral  

In 2010, with his New York Times Bestselling book The Paleo Solution, Robb Wolf presented the answers that enabled me to recover my health. His podcast of the same name launched my business and connected me with the incredible partners who helped shape NBT into an online clinic that has now helped over a thousand athletes achieve optimal health and performance. In his new book, Wired to Eat, Robb carefully examines the neuroregulation of appetite as this is necessary for eating enough to be healthy, but not so much that we see weight gain and the plethora of Western degenerative diseases such as cardiovascular disease, neurodegeneration and type 2 diabetes. Robb's primary goal with this material is to remove the guilt and shame many people feel around making changes in their food and movement. We STILL need to do the work, but if we understand this may legitimately be a challenging process, we can avoid the sense of failure and self-loathing. Mixed into all this Robb talks about sleep, photoperiod, stress, digestion, the gut microbiome, autoimmunity. It’s a lot of material, but we think it covers most situations and will be helpful whether one is struggling with weight or is a top tier athlete. Learn more about Wired to Eat, including the special launch bonuses! Sign up for our Highlights email and every week we’ll send you a short (but sweet) email containing the following: One piece of simple, actionable advice to improve your health and performance, including the reference(s) to back it up. One item we read or saw in the health and fitness world recently that we would like to give a different perspective on, and why. One awesome thing that we think you’ll enjoy! Here’s the outline of this interview with Robb Wolf: [00:00:41] Robb’s first book was The Paleo Solution: The Original Human Diet (2010). [00:01:31] The Paleo Solution podcast. [00:01:51] Amelia Luker, RN, is my ultra hard working employee #1 who makes much of the NBT of the magic happen. [00:02:44] Marty Kendall has a fantastic website and Facebook group both named Optimising Nutrition. [00:04:25] Sign up for our weekly highlights email. [00:05:35] The first book was so successful, why write a second? [00:06:38] Customisation was lacking in the original approach. [00:07:21] Whole30. [00:08:09] We are wired to eat. [00:10:52] Most health and fitness books are ghostwritten. [00:12:55] Why not a retreat, or a training course, or self-publish? [00:13:56] Tucker Max: Book in a Box. [00:14:46] Reno Risk Assessment Program (explicit). [00:15:45] Lorain Cordain and Gary Taubes. [00:15:53] Dr Jim Greenwald. [00:16:30] 22M savings, 33:1 return on investment. [00:17:04] Dr Gerald Reaven. [00:18:51] Workman's comp 1.5M cost? [00:21:20] Train the trainer. [00:24:06] Biomarkers to identify “the dead man walking.” [00:24:46] William Cromwell, MD, Discipline Director, Cardiovascular Disease at LabCorp. [00:25:26] LDL-P. [00:27:14] Ivor Cummins (aka The Fat Emperor), and the late Dr Joseph Kraft. [00:28:29] Book pre-order bonuses. [00:30:12] Thrive Market. [00:32:16] The Paleo Diet is “more misunderstood than a goth kid in Arkansas.” [00:32:41] Continuous glucose monitoring (CGM). [00:34:29] Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094. [00:37:39] Glucose challenge in hunter gathers. [00:38:58] Does one size fit all for glucose tolerance? [00:40:56] Chris Masterjohn, PhD. [00:46:00] The septic patient. See Robb’s talk at UCSF. [00:46:32] Lipopolysaccharide (LPS). [00:50:58] Straub, Rainer H., and Carsten Schradin. "Chronic inflammatory systemic diseases An evolutionary trade-off between acutely beneficial but chronically harmful programs." Evolution, medicine, and public health 2016.1 (2016): 37-51. [00:54:52] Managing complexity. [00:57:08] Photoperiod. [00:58:27] Crossfit and martial arts. [00:59:56] What should I do when I grow up? [01:00:18] Myers-Briggs personality test. [01:01:39] Economic risk tolerance. [01:02:34] Physician's assistant. [01:04:58] Cleveland Clinic Functional Medicine. [01:05:11] Kresser Institute. [01:06:10] Rheumatoid arthritis. [01:07:33] f you own a gym or other business and would like to sell copies of Wired To Eat you can pre-order in bulk! Please send email to hello@robbwolf.com with “Bulk order” in the subject line for details.

Host: Alan S. Brown, MD, FNLA Dr. Alan Brown is joined by Dr. Thomas Dayspring, Director of Cardiovascular Education for the Foundation for Health Improvement and Technology in Richmond, VA and clinical assistant professor of medicine at the UMDNJ - NJ Medical School. He is also a Fellow of both the American College of Physicians and the National Lipid Association. The two discuss Dr. Dayspring's research on discordances between LDL-P and ApoB, two biomarkers that are otherwise thought to correlate well with one another.

AIR DATE: August 29, 2013 at 7PM ETFEATURED EXPERTS: FEATURED TOPIC: "Cholesterol Clarity Q&A"   With the much-anticipated release of the book  by Jimmy Moore and Dr. Eric Westman, both of the coauthors joined us on "Ask The Low-Carb Experts" this week for a Q&A session answering listener questions about this critically important new book about the subject of cholesterol. This book was written to fill a major void in the marketplace of an easy-to-understand manual on cholesterol, why it's not the evil substance we've been led to believe, what really matters the most on your cholesterol panel, and which levels are optimal if you are going to pay attention to cholesterol. Here's your exclusive chance to hear directly from both Jimmy and Dr. Westman answering listener questions about the book. That's what we've got for you in Episode 43 of "Ask The Low-Carb Experts" in this Cholesterol Clarity Q&A. Get (or download the ) from Amazon.com: SUGAR-FREE, LOW-CARB PEANUT BUTTER CUPSNOTICE OF DISCLOSURE:  Here are some of the questions we address in this episode: ROXANNE ASKS:I have read and enjoyed books by both of you and am very much looking forward to reading Cholesterol Clarity! I am a 53-year old diabetic female who had heart bypass surgery 6 months ago. There is a history of cardiovascular issues on both sides of my family. I've read that statins can have some rather serious side effects. What, if anything, can you say to me and my doctor to convince us that it would be safe for me to stop taking the 10mg Lipitor I am now taking? JAMES ASKS:So what's the deal with plant sterols? I see it for sale as a supplement to "lower your cholesterol" and I see people taking it. Is there any benefit to it? What about the harm in taking it? I follow a low-carb, high-fat lifestyle, so I get plenty of dietary cholesterol from animals. TRAVIS ASKS:I have a one word question: Eggs. I eat at least three eggs a day everyday for breakfast along with some cheese and bacon. I feel this kind of large low-carb breakfast really gets me through the day. However, I can't find any consensus about eggs. Are they good, good in moderation, bad long-term, or will eating 21 eggs a week kill me? KEVIN ASKS:I've read that higher serum cholesterol could be a clue that something else is going on in the body—for example, tissue damage that needs repair, or a decreased ability for cholesterol to be delivered into cells. Could you please talk about the role of LDL in particular, and what an increased level might indicate about other health factors? KEN ASKS:The homeostatic model for serum cholesterol appears to be well worked out for a standard high-carb diet. Do you think that the correct model is substantially different for a ketogenic low-carb, high-fat diet, and that this might be the reason for the large number of "hypercholesterolemic" responses on this diet? Might the small intestine, instead of liver, be the dominant source of endogenous cholesterol on this diet? DENNIS ASKS:My question is about the effect of fructose, sugar alcohols, and alcoholic beverages on your triglycerides. Would the fact my triglycerides are crazy high at 260 while everything else is fine mean that I should limit these things in my diet? JULIE ASKS:I have been diagnosed with a number of health issues including diverticulitis and Type 2 diabetes. Since then, I have been doing Paleo and cut out all gluten, sugar and high carb foods in my diet. I discovered that going ketogenic was right for me. Before I went keto, I had blood work run with the following results: Total cholesterol — 265HDL — 64LDL — 176Triglycerides — 158A1c — 5.8 The next time I had blood work done was 6 months later. I asked for a VAP test and, although my doc doesn't understand how to read this test, she ordered it for me on my insistence. I moved towards a higher-fat diet and lost 40 pounds over that time since my last cholesterol panel. Here are the numbers: Total cholesterol — 313 (my doctor was pushing statins)HDL — 108LDL — 187Triglycerides — 77 To tell you the truth, my doctor had no idea how to interpret the more advanced numbers on my VAP test and I don't understand it either. I didn't accept the idea that I needed to go on a statin drug but I am greatly concerned with this very high 300+ total cholesterol level. So how do I interpret these cholesterol tests and what should I be doing differently in my diet to work on any weakness in these results? What exactly should I be looking for to track my progress? MARYANN ASKS:The only guidelines I repeatedly see for the ApoE genotype 3/4 and 4/4 people are this: exercise, avoid smoking, abstain from alcohol and cut your saturated fat intake. Do you agree with these recommendations, especially the mandate to cut down on saturated fat? If so, how do you advise you patients who are eating low-carb, high-fat to reconcile this mandate to basically limit or avoid saturated fat with all that we know about the life-saving benefits of eating this way? What do people with this ApoE genotype gain by avoiding saturated fat? PATHOLOGIST DR. SMALL:I’m 59 years old and went low-carb about a year ago and my HDL rose from 50 to 77 and my triglycerides dropped from 92 down to 38. My cardiologist was stunned and asked me how I got such an outstanding triglycerides/HDL ratio with an outstanding CRP level of .4 and an carotid artery scan that show I have the arteries of an 18-year old. But he was not impressed with my LDL being above 130, my ApoB rising to 102, and my LDL-P coming in at 1500. How do you prioritize the favorable readings against the somewhat unfavorable ones? Do Heart Calcium Scores from a CT scan really tell the tale of where you stand with actual disease taking place in your coronary arteries? HOLLI ASKS:I'm wondering how I can raise my LDL cholesterol levels since they seem to be too low. I haven't tested recently, but my previous test showed my total cholesterol is 142, HDL is 78, LDL is 71, and triglycerides are 50. I've been working on correcting a leaky gut and eating a Paleo/GAPS diet for the past year. My energy is very low, I’m always tired and my hormone levels are all on the low end of normal. I'm wondering if my too-low cholesterol could be part of the problem and if so, what can I do to raise it? I am not taking any cholesterol-lowering medications. DAVE ASKS:I went to my doctor and he says I am in the "dangerously high LDL range" and I should stop eating my low-carb high-fat diet and reduce my egg consumption to no more than 3 per week. My last lab results were the following: Total cholesterol – 254LDL – 186HDL – 52Triglycerides – 82Blood glucose – 79 Over the last three years, my triglycerides have decreased, HDL increased, LDL increased, blood sugar decreased and weight decreased. I used to take a statin drug, but I will never take it again. I realize I probably shouldn’t worry about it, but my doctor went crazy about my numbers. Is the increase in my LDL cholesterol something I can choose to ignore or should I modify my diet to reverse the upward trend? JW ASKS:Is it possible that the rise in either total cholesterol or LDL-P that some people report while on a ketogenic diet is due to the fat leaving the adipose tissue as they lose weight? Are there any studies that show if it persists or goes away once weight stabilizes? And if your HDL is higher than your triglycerides while your fasting blood glucose level is under 100, do you care what total cholesterol or LDL-P is assuming there is no familial hypercholesterolemia?

AIR DATE: June 20, 2013 at 7PM ETFEATURED EXPERT: FEATURED TOPIC: "What Are 'Normal' Lab Values?" Have you ever gotten back test results from your doctor and were relieved to see that you were in the "normal" range with your lab values? Did you ever stop to ask yourself how they came up with these numbers? What if you are in the normal range on a particular test, but you still have symptoms in your health that make it obvious you are still not well? These are just a few of the questions we addressed in this week's episode of "Ask The Low-Carb Experts" with a low-carb/Paleo-friendly family physician named  from King, North Carolina. He has a special interest in measuring fasting insulin and ketone levels as well as testing his patients for vitamin deficiencies. As you will quickly see, Dr. Graham is quite opinionated and more than willing to stretch the boundaries of "traditional white coat medicine." That made him the perfect choice to answer YOUR questions about the topic What Are 'Normal' Lab Values? on this week's show. LOW-CARB CHOCOLATE CHIP COOKIE DOUGH QUEST BARSNOTICE OF DISCLOSURE: SUGAR-FREE, LOW-CARB PEANUT BUTTER CUPSNOTICE OF DISCLOSURE:  Here are just a few of the questions addressed in this podcast: KELLY ASKS: I’ve read that the "normal" ranges on most lab tests are actually averages of all the tests results that the lab has conducted. Why this is so frightening to me is because most of the people who are having tests run have something WRONG with their health. This means the supposedly "normal" values are really clouded with a lot of sick people’s numbers and the more tests run on sicker people the more "normal" sick actually becomes. Is this actually how it works or do I have it all wrong? LESLIE ASKS: As with modern infant growth charts, I often wonder what's considered normal these days. My family doctor has joked with me that according to her charts I should be dead with blood pressure of 110/60 and a resting heart rate of 54 as a woman in my late 50s. SIMON ASKS: I’m a lean, fairly healthy 26-year old man and I've been following a low-carb ketogenic diet since the beginning of April 2013 because I didn’t like feeling constantly hungry on a high-carb diet. I had a blood test done at the end of May and my uric acid levels were out of the normal range measuring 7.2 mg/dl. The normal range specified is 3.6-7.0 mg/dl. Should this be cause for concern? Are my kidneys perhaps still adapting to the presence of ketones? By the way, my total cholesterol is 223 mg/dl and my triglycerides are 139 mg/dl. EDWARD ASKS: I was wondering if the lab standards for blood pressure are somehow biased. I'm an American born citizen of Asian descent and lived on a diet of rice for many years. It never bothered me that my blood pressure was considered Stage One Hypertension as I personally felt fine. However, with the medications I'm taking, I now feel tired and sluggish simply with the goal of lowering my blood pressure because it’s not in the right range. Can you help me understand this? LISA ASKS: I had a regular CBC done recently and my BUN level came back as 23. The lab test states that normal is between 7-18. The doctor hasn't recommended anything for me to do about this. I follow a lower-carb diet compared to the SAD diet and I don't eat a lot of sugar. Should I be concerned about my BUN levels being so high? TONY ASKS: Other than the typical blood test markers physicians run to gauge the general health of their patients, what are the top 5 blood markers people should be paying most attention to after the age 40? Are they different for males vs. females? ARI ASKS: What do you think about the seemingly high prevalence of low-carbers, including Jimmy, who have very high LDL-P numbers but no other signs of imminent heart disease risks? I realize there is very little research on this right now, but would love to hear Dr. Graham’s personal experience on this subject working with patients eating a low-carb diet. KEN ASKS: Between the standard lipid panel, NMR Lipoprofile test, CMP panel, and CBC panel, which 3-4 numbers should folks be most concerned about to determine their cardiovascular and overall health risks? RICHELLE FROM AUSTRALIA ASKS: What is the significance of lactate in the blood particularly in the context of mitochondrial function? What other blood markers are good to keep an eye on to monitor mitochondrial function? Also, what are the best tests to monitor nutrient requirements in the body?

AIR DATE: June 13, 2013 at 7PM ETFEATURED EXPERT: FEATURED TOPIC: "All Things Thyroid (Thyroid 201)" The thyroid gland serves one of the most under-appreciated and yet totally misunderstood functions within the human body. If someone is dealing with excessive weight on their body, you might hear them say something along the lines of it being due to having a bad thyroid. But there's got to be more to it than that, right? What is at the root cause of why your thyroid might not be functioning at optimal levels? And what steps can be taken to fix these thyroid issues without resorting to taking potentially harmful prescription medications? That's what we'll be exploring with a Walnut Creek, CA-based functional medicine physician named  (listen to my interview with him in ). Dr. Ruscio specializes in the subject of thyroid health (and has  to tell) which is why he will being joining us to talk about "All Things Thyroid (Thyroid 201)." You might recall we had the great  on to talk about this subject back in  to give a Thyroid 101 introduction to the topic. But Dr. Ruscio will help us dig even deeper into answering YOUR most pressing questions about thyroid health and how it relates to your healthy low-carb, Paleo lifestyle. If you want to get a taste for what his teaching style is like, then be sure to check out  for lots of informative videos on this subject and more. Dr. Ruscio joined us in Episode 39 of "Ask The Low-Carb Experts" to keep the conversation going on the vital importance of attaining and maintaining good thyroid health. Here are just a few of the questions we addressed in this podcast: DANIELLA ASKS: I'm a 36-year old mother who recently started eating a low-carb Paleo lifestyle. I consume 1500-1600 calories most days and take in about 50-60g of carbohydrates daily. My energy is great and I look and feel the best I have ever felt in my life. Sleep and athletic performance are incredible as well and my muscle definition at 5’3” tall and 110 pounds has never been better. My only concern is that I take 60mg Armour thyroid daily and I am concerned that my low-carb diet may interfere with thyroid function. I feel like I eat adequate calories most of the time, but should I be concerned? My last labs showed everything to be good: TSH 0.6, Free T3 at 2.2, free T4 at .8. KATHERINE ASKS: I'm 39 years old and I've been on a low-carb diet (40-70g carb per day) for 22 months in response to pre-diabetic blood sugar levels. Since changing my diet, my T3 has dropped and is now borderline low. Initial thyroid tests 22 months ago were all normal. I've done some casual reading in recent months that a low-carb diet can suppress thyroid function. In other places I've read it can help it. Can you please help clear up this confusing issue? & NANCY ASKS: I have actually been struggling with the low-carb concept out of fear of ruining my thyroid. There is so much conflicting information out there with regards to low-carb being bad or good for thyroid. I’ve heard that women should not be on a low-carb diet for too long or at all because of the risks to their thyroid function. I am already obese at 5'1" and 184 pounds and I feel lost and not sure which nutritional path to take. KEN ASKS: I've been eating Paleo over the last year and recently had an NMR test. My LDL particle count was very high at 1403 with my small LDL coming in at 492. HDL is 62 and triglycerides are 50. I was wondering if you could further explain the role the thyroid plays in the particle count levels and whether those of us eating a low-carb Paleo diet should be worried. It seems many of us eating this way, including Jimmy, have high LDL-P and I’m curious if our way of eating is making this happen. JUNE ASKS: Do you have a preference between Armour vs. Nature Thyroid? RICK ASKS: What are your thoughts on treating thyroid disease with high levels of iodine supplementation? WENDY ASKS: I have been taking 30 mg of Armour Thyroid and have been Paleo/Primal since Jan 2011. I eat fish 2x per week. I avoid raw cruciferous veggies and take a drop or two of a concentrated iodine supplement weekly as I don't want to overdo it. I recently started adding kelp sprinkles daily to my food and would like to stop having to take thyroid medications if at all possible. Is this doable? JACKIE ASKS: I had thyroid cancer in 2008 and had a total thyroidectomy. I'm currently taking 200 mcg of Synthroid daily. Since the thyroid controls metabolism, how do I increase my metabolism to lose weight? I’m 57 years old, 5'2" tall and weigh 260 pounds. DEANNA ASKS: I did the HCG diet over 2 years ago and lost nearly 40 pounds. Since then I have slowly gained almost all of it back. I am having hypothyroid symptoms (hair loss, brittle nails, cold hands and feet) the main one being a total inability to lose weight no matter how hard I try. I eat mostly Paleo. What are your thoughts about the HCG diet and its effect on thyroid function? I have read that it could affect reverse T3 but there are a lot of functional medicine doctors advocating it. PAUL ASKS: What are Dr. Ruscio’s thoughts on the Endocrine Society's updated clinical practice guidelines for the management of thyroid health in pregnancy? They seem to be quite controversial. LINDA ASKS: I read that eating one Brazil nut a day is enough to bring up a low thyroid to normal levels. Is that true? What other foods can help with this? JASON ASKS: Is the excessive fluoride typically added to the drinking water in local municipalities something to be worried about because of iodine absorption issues and by extension be a contributor to hypothyroidism? INGE FROM MELBOURNE, AUSTRALIA ASKS: I lost weight after my sister died in 1993 and at the age of 40 I developed a taste for alcohol that killed my thyroid. For 10 years the specialist put me on Thyroxin until my blood pressure became very high due to a lack of T3 stimulation. She then put me on 7 grains of thyroid extract and I started losing weight again. I’m now seeing an integrative doctor who is not happy about this high dosage of thyroid extract. He told me to back off of it and now I’m gaining weight again putting on 8 kg, I sleep 10 hours a night, I retain fluid, I can no longer exercise because I’m so exhausted all the time and I have severe brain fog. Do you have any suggestions for me? MELANIE ASKS: I just got diagnosed with Adrenal Fatigue that according to my doctor is causing Functional Hypothyroidism. So my Free T3 and T4 were in the normal range, but at the lower end. I need to fix the adrenal fatigue issue but I also need to be supporting my thyroid so that it doesn’t get any worse. I'm pretty familiar with ways to support the thyroid, but wanted to ask the opinion on taking animal glandulars. I wonder if Dr. Ruscio is familiar with the Xymogen T-150 thyroid support product (a freeze-dried, BSE-free, bovine, multi-glandular, mineral and herbal formula to support healthy thyroid function). Do you have an opinion on it? My doctor wants me taking it. ROGER ASKS: Before I went low-carb Paleo, I knew my thyroid wasn’t functioning well. My Free T3 and T4 levels were horrible and I was feeling sluggish. Is a short-term supplementation of pregnenolone a good way to boost thyroid health and balance other hormones? CATHY ASKS: I started Synthroid for hypothyroidism in January and quickly developed a bad case of acne. Is this just a coincidence or did the medication cause this? AMBERLY ASKS: The thyroid tests done by my doctor were all normal, but then I started going to another doctor who specializes in bio-identical hormone replacement. He said that one of them was low, maybe the Free T3. He put me on Armour thyroid to treat it. When I asked him if this could have any negative effects, he said that it could shut my thyroid down, but that since my thyroid wasn't functioning as well as it needed to on its own. Thus, he convinced me it would make sense to go ahead and start the Armour since it wasn't going to get any better on its own anyway. My Free T3 is now slightly too high. Do you agree with this doctor’s aggressive approach?

Low-density lipoprotein cholesterol, a key cardiovascular biomarker is recommended by National Cholesterol Education Program, Adult Treatment Panel Guidelines, for assessing cardiovascular disease risk and for monitoring lipid-lowering therapy; however, some workers believe that the number of circulating LDL particles rather than LDL cholesterol is a strong indicator of future cardiovascular disease events.

AIR DATE: November 1, 2012 at 7PM ETFEATURED EXPERT: FEATURED TOPIC: “Finding The Diet That's Right For You” If you've been listening to my podcasts or read my blog for any length of time, then you've obviously heard me talk about one of the basic philosophies that I think is an important part of living a healthy lifestyle. Here it is: "Find a diet plan that is right for you, follow that plan exactly as prescribed by the author and then keep doing that plan for the rest of your life making appropriate tweaks along the way to keep it working." But how do you go about figuring out what the "right" diet and lifestyle plan is for you? That's what we'll be exploring further in Episode 33 of "Ask The Low-Carb Experts" with a highly-qualified guest expert named  (listen to my March 2012 interview with Peter in ). TRY THESE DELICIOUS NEW PRE-MADE PALEO MEALSUSE COUPON CODE "LLVLC" FOR 10% OFF YOUR ORDERNOTICE OF DISCLOSURE: TRY THE WORLD'S FINEST CACAO BEAN LOW-CARB CHOCOLATEEnter "LLVLC" at checkout for 15% offNOTICE OF DISCLOSURE:  Here are some of the questions we addressed in this podcast: RENEE ASKS:I have been refining what I think is my perfect diet for about 3 years now. During that time my diet has drastically changed for the better. I eat a very strict Paleo autoimmune diet with no dairy, nuts or nightshades. This has worked very well for me and now I am experimenting with a few little things here and there to tweak my diet that help me go from feeling good to feeling great. I am wondering about the cross-reactivity of coffee with gluten. I have heard that this can be a problem for some people, but I dismissed it because I didn’t want to believe that it can be a problem for me. But now I’m thinking that it IS a problem for me because after quitting coffee I started losing weight with no other changes in my diet. And it's not just calories because I replaced the coffee with a coconut oil cocoa that would have equal calories since I made my coffee into a coconut oil latte anyway. I know that gut issues are the minority of manifestation of gluten intolerance, so this effortless weight loss might be showing some type of healing. I also heard that a study came out early this year confirming that a coffee/gluten cross reactivity is a significant problem. What are your thoughts on this issue? MICHAEL ASKS:I'd like to hear Peter address hypercaloric feeding on a ketogenic diet in combination with weight training. Is it possible for someone who is already basically lean and healthy to overeat and train his way up in size? What is the likely practical limit to size gain and performance in weightlifting with insulin levels being kept very low? MIKE ASKS:I have found success stabilizing my weight on a diet of 20-30g of carbs per day. However, I can't seem to lose those last stubborn pounds. I am a 5'8" male and currently weight 160 pounds with 19% body fat. My goal is to get down to 15% body fat. I started monitoring my ketones and after a month was able to lose another 4 pounds and 1% body fat, but it was very hard for me to maintain the high percentage of fat in my diet required to get my ketones high enough. Recently I started slow lifting and I really like that program. But when I increased my protein to aid muscle development I knocked myself out of ketosis and am right back to the 19% fat, 160-pound mark. I suspect a hormonal problem is contributing to the difficulties in losing but I’ve tested my testosterone twice and both times it’s near the high end of the "normal range." Recently my TSH also tested fine at 1.9, my Free T4 Direct was in the middle of the lab range at 1.32, and my TPOab was also in the middle at 12. My Free T3 was on the low end of the lab range at 2.2 (with the lowest reference range being 2.0). Given all of the above, are there variations I could try in my diet that could get me unstuck and help me reach my goal? MARYANN ASKS:I’m a 76-year old woman with the H63D gene for hemochromatosis and have high ferritin. My latest test was 436 and it goes up and down with an all-time high of 625. My doctors says that a phlebotomy is unnecessary unless it goes over 1000. I also have paroxysmal atrial fibrillation which I understand eating the Paleo way is the best for this. My A fib discussion board members say my ferritin is way too high now. What diet would you say would be the best for me? TINA ASKS:I am 42 years old and have been overweight since having children in my early 20s. I am 5'4" and weigh 199 pounds. My A1c was 5.8 when I check it a few months ago and my doctor advised me that I’m at risk for Type 2 diabetes and that I need to start exercising 30 minutes per day. I have been playing around with low-carb/Paleo and primal diets for the past few months but I can't decide which way to go. I have read tons of information and listen to many health podcasts like the ones from Jimmy Moore, Balanced Bites and Fat Burning Man. Where do I start? I crave sweets at least once a day and that continues to be my biggest downfall. How do I pick the diet that’s right for me? PALEOZETA FROM AUSTRALIA ASKS:I would like Dr. Attia to talk about intermittent fasting and…well, diarrhea. Sorry. About 10 minutes after I eat again following an intermittent fast, which works very well for me in conjunction with my ketogenic diet, I tend to have one or two bouts of diarrhea. I was reading that it could be our body expelling the toxins in it, but I’m not so sure about that. I’ve heard other people who do IF having this same issue. Do you have any insights about this? JAN ASKS:I'm a peri-menopausal woman, and I eat a low-carb, high-fat version of primal. My doctor is pushing statins on me strictly on the basis of my LDL-C which registered in at 142 using the Freidewald Equation. My HDL is 79 and my triglycerides are 71. Because of my insurer and financial situation, getting an NMR Lipoprofile test to measure my LDL-P is out of my reach to better assess my risk factors. I can't even get them to do a C-Reactive Protein test to assess whether there's inflammation. Is there any dietary tweak I can make to bring LDL-C lower without negatively impacting my excellent HDL and triglyceride readings? ERIC ASKS:It seems very timely that Dr. Attia will be on your podcast, Jimmy, as your latest Apo B results showing 238 and an LDL-P score of 3451 would appear to be quite alarming based on his recent “The Straight Dope On Cholesterol” series. Since Dr. Attia is a huge fan of ketogenic diets AND has a lot of knowledge about the importance of lipid markers, I would imagine he would be in a fantastic position to help clarify what is going on here. He seems to believe that the Apo B number is one of the most important markers of cardiovascular health. By the way, what is Dr. Attia’s Apo B number? JACK ASKS:Since cycling is a topic that is rarely addressed in Paleo/low-carb circles, does Peter have any tips for maximizing endurance athletic performance while on a ketogenic diet? Whenever I try to do cycling while in ketosis, I often feel fatigued and lose some of my power. Alternately, if I eat a lot of carbs and sugar-laden cycling food, I get stomachaches and feel bloated and grouchy most of the ride. Peter's blog has been the only thing I've ever seen talking about this topic and I’d appreciate hearing more from him about this. ROGER ASKS:Does a ketogenic diet repair or re-regulate an underactive thyroid? I’ve been on this diet for a year and a half now, but my hypothyroid symptoms still exist although I feel much better. My latest blood tests suggest I have low T3. I’m athletically built, never been overweight and exercise moderately. I’m wondering if Dr. Attia is a proponent of doing any thyroid supplementation in conjunction with a ketogenic diet as a beneficial approach to treating these hypothyroid symptoms? MICHELE ASKS:I heard you mention on your previous podcast with Jimmy that you use vegetables as a vehicle for consuming more fat. How important are vegetables in the diet if you’re eating a high-fat, low-carb diet? I always get confused because you hear how important it is to eat a lot of vegetables but I’m not particularly fond of a lot of them when trying to increase my ketones. TOM ASKS:We often hear the phrase used in the low-carb community that “there’s no dietary requirement for carbohydrate.” I’ve always assumed this comment was directed at the usual suspects like breads, cereals, pastas, legumes, etc. However, I have to ask, are vegetables really necessary to consume? In my case, I’m referring to non-starchy vegetables, such as kale, Brussels sprouts, cauliflower, and so forth. While vegetables contain vitamins, nutrients, fiber, and phytochemicals, I’ve read that cruciferous vegetables are also potentially goitrogenic. Cooking these vegetables for long periods of time supposedly helps to mitigate any deleterious effects, but the suggested cooking time is a minimum of 30 minutes. So what’s the scoop on veggies? DARREN ASKS:Over the past year and a half, I've been following a low-carb diet stopping short of nutritional ketosis. I'd put my daily carbohydrate input close to 100g out of a 2700- calorie diet. It has allowed me to accomplish and exceed the goals that I set out to do: - Lowered my Triglycerides from ~330 to

AIR DATE: October 4, 2012 at 7PM ETFEATURED EXPERT: FEATURED TOPIC: “Cholesterol Testing: What Matters Most?” This week we're very excited to bring to you one of the world's leading lipidologists and experts on just about everything you could ever want to know about cholesterol numbers named  from . He's the Director of Cardiovascular Education at the  in Richmond, Virginia and is one of the most requested speakers in the United States with expertise on atherothrombosis, lipoprotein and vascular biology, advanced lipoprotein testing and more. Dr. Dayspring has given over 4000 lectures in all 50 states educating medical professionals and the lay public alike. Many of you first heard him in  and afterwards had lots of questions for Dr. Dayspring about cholesterol. That's why we decided to bring him back on ATLCX to take on the topic "Cholesterol Testing: What Matters Most?" so you can speak directly with him about your burning questions on your cholesterol concerns. This was a golden opportunity to get clarification on any issues regarding cholesterol testing that concern you. TRY THESE DELICIOUS NEW PRE-MADE PALEO MEALSUSE COUPON CODE "LLVLC" FOR 10% OFF YOUR ORDERNOTICE OF DISCLOSURE: TRY THIS NEW LOW-CARB SNACK OPTION FROM NICK'S STICKS:NOTICE OF DISCLOSURE:  Here are some of the questions we addressed in this podcast: COLLEEN ASKS:In an ideal world, should everyone know what their LDL-P number is? What is the ideal number or target range for LDL-P? How important is LDL-P as a biomarker for risk of heart disease? Other than diet, what would be common causes of high LDL-P? TRISTA ASKS:If someone has high cholesterol (mine is 307 total, 48 HDL, 239 LDL, and 95 triglycerides with mostly Pattern A LDL cholesterol), is that a reason to stop eating a low-carb diet? And who would you say needs to be taking a statin drug as an appropriate treatment option for lowering cholesterol numbers? UROLOGIST FROM BRAZIL NAMED J.C. ASKS:We know that statins raise insulin resistance and can interfere with blood glucose control in Type 2 diabetics. I have a patient who has already had two heart attacks and seen great improvements in his health since adopting a low-carb diet. Would you consider taking him off simvastatin if his Apo-B remains low after stopping the medication? And for those of us who live outside the United States, how good is an Apo-B test as compared with the NMR Lipoprofile? What is the desirable value for Apo-B? ANDREI ASKS:Do other favorable test readings, such as large fluffy LDL particles, high HDL, low triglycerides or low CRP levels, singularly or in combination, reduce the risk of heart attack posed by a very large LDL-P number? DANNY ASKS:You mentioned in your previous interview with Jimmy that sterols, not just cholesterol, have the potential to incorporate into arterial plaque. I did some research and  where arterial plaque was scraped and analyzed and a direct relationship was established between the amount of plants in the diet and the amount of plant based sterols that end up in the arterial wall. What is the mechanism behind plant sterols becoming plaque? Does the addition of plant sterols in the diet make our lab results, especially the calculated LDL tests, look good for no real benefit? And if this is true, why does cholesterol get a bad rap and these sterols enjoy the halo of healthiness? ORLEATHA ASKS:Recently, Paleo diet practitioner Chris Kresser wrote in a blog post that "the number of LDL particles in the blood...is a risk factor for heart disease." After getting an NMR Lipoprofile test run, what number should be cause for concern? BRIAN ASKS:How do cholesterol numbers get calculated? We see LDL, HDL, triglycerides and total cholesterol. And why isn't the NMR Lipoprofile test the standardized cholesterol measurement in the medical profession yet? SHARI ASKS:Is it possible for someone to have too low cholesterol? My total cholesterol has never been more than 95 testing over the past 15 years. Some people in the Paleo community have said I should be very concerned but my general practitioner thinks my very low cholesterol is great. What do you say? FORTUNE ASKS:What should APOE 3/4 or even 4/4 people look for in their lipid tests given that they will probably not be "normal?" And what should APOE 3/4 or 4/4 do to reduce their risk? IKE ASKS:My question is in regards to the test that is performed by Health Diagnostics Laboratory Inc called the Apolipoprotein E Genotype. What are the implications on the lipids of a high-fat, low-carb dieter with the 2/4 genotype combination? I believe that this occurs in 1-2% of the population. Would these people need to eat less saturated fat? WILLIAM ASKS:You have said in more than one interview I have heard that you believe it really boils down to the LDL particle number and that particle size is not as important. With that in mind I would think the Lp(a) test would be all you would need to run to obtain that information. So, what is the BEST, most cost effective lab test to have done if you could do only one test to give you the most information about heart disease risk? ANN ASKS:Does what I eat in the few days prior to my lab draw make a difference in my Apo B and small LDL-P...especially if I overindulge in carbs the day before the draw? If a lab report gives both Apo B and LDL-P and one is high and one is normal which one do you go with? ALLYSON ASKS:Why do you see HDL decrease with autoimmune diseases such as lupus? Is it associated or causal? Does the HDL decrease in response to the disease? Why do you suspect hyper absorption when you see high HDL-C? KAY ASKS:I have been eating low-carb Paleo since January and have lost 45 pounds. I just went to the doctor for the first time since 2007 and he ran blood work. My total cholesterol went up to 334, mostly LDL, and the doctor is alarmed. In order to prevent my doctor from ordering me to take statins, I told him that I had read that losing more than 30 pounds within a few months can temporarily elevate total cholesterol, and that I would have another blood test done in 3-6 months. Is it true that my weight loss may be the reason for the jump in total cholesterol and LDL? ED ASKS:I had the NMR test and it reveals an elevated (high risk) LDL-P count of 1573 but also a calculated, intermediate risk of Apo-B of 62. I recently noticed that these results were from a non-fasting test. Is it possible that the LDL-P and APO-B (both particle counts) are affected by the fact the the test was done in a non-fasted state? Would you recommend this test only be done in only a fasted state? RICHARD ASKS:It has been stated by Chris Masterjohn that within the same individual, cholesterol readings can vary from day to day. In fact, it was reported that total cholesterol has a standard deviation of +/- 17.5 points meaning that a reading of 200 for example, could easily vary between 165 and 235 over a two-day period. So if this is accurate, how meaningful are the various cholesterol readings particularly since most MDs only get one test and make their decisions based on that singular piece of data?