Podcasts about apob

Why does your body start to feel different around 35? Dr. Barrett breaks it down for both men and women in under 15 minutes. For men: declining total and free testosterone, insulin resistance, and slower recovery capacity - plus what to fix before jumping to TRT. For women: functional iron deficiency (even with "normal" labs), muscle loss, and cardiovascular markers like ApoB and homocysteine that often get missed. Practical, no-fluff strategies throughout.. . . Watch the episode on YouTube here! Click here to view the episode transcript! Podcast Team Dr. Barrett Deubert - Host Grant Crenshaw - Editor (00:00) - Intro (00:50) - Why Your Body Feels Different at 35 (01:39) - Male #1: Testosterone & Free T (04:22) - Male #2: Insulin Resistance (06:16) - Male #3: Recovery Capacity (08:26) - Transition to Female Health (08:44) - Female #1: Functional Iron Deficiency (10:50) - Female #2: Muscle Mass (12:04) - Female #3: Cardiovascular Markers (ApoB & Homocysteine) (14:13) - Closing Thoughts DISCLAIMERThis content is strictly the opinion of Dr. Barrett Deubert and is for informational and educational purposes only. It is not intended to provide medical advice or to replace medical advice or treatment from a physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding health questions and concerns. Neither Dr. Deubert nor the Real Health Co. takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All audience members, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.

Welcome to the latest Midlife Minute. This episode unpacks ongoing research on Lp(a), explores how women's lipids change during the perimenopause-to-menopause transition, and clarifies what we can do about it. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: How total cholesterol, LDL, and ApoB tend to rise most steeply around the final menstrual period, rather than increasing gradually with chronological aging Why women should have their Lp(a) checked both before and after menopause How oral and transdermal estradiol can affect LDL, HDL, triglycerides, and Lp(a) differently Why I recommend including ApoB when checking your lipids during the perimenopause window How your lifestyle can reduce your cardiovascular risk, even when your Lp(a) is elevated Why omega-3 fatty acids and commonly used lipid medications do not lower Lp(a) Why supplements are not replacements for statins in genuinely high-risk patients  I review the various PCSK9 inhibitors currently available, how they are administered, and their effects  How a CAC, a CT angiogram, and an AI-assisted CT angiogram can help women and their providers determine how aggressive their approach should be when Lp(a) is elevated Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: 1. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association.Circulation. 2020. El Khoudary SR, Aggarwal B, Beckie TM, et al.Guideline 2. Menopause: A Cardiometabolic Transition. The Lancet. Diabetes & Endocrinology. 2022. Nappi RE, Chedraui P, Lambrinoudaki I, Simoncini T.Review 3. Dyslipidemia Across the Menopause Transition: Mechanisms, Trajectories, and Opportunities for Cardiovascular Prevention. Maturitas. 2026. Castaneda R, Tatit CP, Hurtado Andrade MD, Faubion SS, Shufelt CL.RecentReview 4. Lipoprotein(a) and Women's Cardiovascular Health: A Review. JACC. Advances. 2026. Michos ED, Saucier S, Mehran R, Koschinsky ML. 5. Lipid Metabolism in Women: A Review. Atherosclerosis. 2025. van Oortmerssen JAE, Mulder JWCM, Kavousi M, Roeters van Lennep JE.Review 6. Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition?. Journal of the American College of Cardiology. 2009. Matthews KA, Crawford SL, Chae CU, et al.Observational 7. Trajectories of Lipids Around the Menopause Transition in Chinese Women: Results of the Kailuan Cohort Study. Fertility and Sterility. 2023. Dai Q, Wu S, Cao Z, et al. 8. Lipid Management in Patients With Endocrine Disorders: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology and Metabolism. 2020. Newman CB, Blaha MJ, Boord JB, et al.Guideline 9. The Effects of Menopause Hormone Therapy on Lipid Profile in Postmenopausal Women: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology. 2022. Nie G, Yang X, Wang Y, et al.SR 10. Perspectives on Dyslipidemia and Coronary Heart Disease in Women. Journal of the American College of Cardiology. 2005. Bittner V.Review 11. Dyslipidemia in Midlife Women: Approach and Considerations During the Menopausal Transition. Maturitas. 2022. Torosyan N, Visrodia P, Torbati T, Minissian MB, Shufelt CL.Review 12. Effects of gender, age and menopausal status on serum apolipoprotein concentrations.13.Lipoprotein(a).The Journal of the American Medical Association. 2025. Mora S, Kronenberg     14. Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications. Diabetes, Obesity & Metabolism. 2025. Razavi AC, Bhatia HS, Blumenthal RS, Shapiro MD, Mehta A.RecentReview 15. Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar. Journal of the American College of Cardiology. 2021. Cicero AFG, Fogacci F, Zambon A.Review 16. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs. 2023. Blais JE, Huang X, Zhao JV.SR 17. Non-Genetic Influences on Lipoprotein(a) Concentrations. Atherosclerosis. 2022. Enkhmaa B, Berglund L.Review 18. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. Journal of the American College of Cardiology. 2018. Tsimikas S, Fazio S, Ferdinand KC, et al.Review 19. Consumption of a defined, plant‐based diet reduces lipoprotein(a), inflammation, and other atherogenic lipoproteins and particles within 4 weeks. Clinical Cardiology. 2018. Najjar RS, Moore CE, Montgomery BD. 20. Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies. Clinical Therapeutics. 2019. Santos HO, Kones R, Rumana U, et al.Review 21. Effect of Lipid-Lowering Therapies on Lipoprotein(a) Levels: A Comprehensive Meta-Analysis of Randomized Controlled Trials. Atherosclerosis. 2025. Xie S, Galimberti F, Olmastroni E, et al.Recent 22. Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia. Journal of Atherosclerosis and Thrombosis. 2023. Ying Q, Croyal M, Chan DC, et al.RCT 23.Lipoprotein(a) and Cardiovascular Disease. Lancet. 2024. Nordestgaard BG, Langsted A.Review 24. Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022. Reyes-Soffer G, Ginsberg HN, Berglund L, et al.Guideline 25.Clinical Trial Design for Lipoprotein(a)-Lowering Therapies: JACC Focus Seminar 2/3.Journal of the American College of Cardiology. 2023. Malick WA, Goonewardena SN, Koenig W, Rosenson RS.Review 26.2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American Collegeof Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026. Writing Committee Members, Blumenthal RS, Morris PB, et al.Guideline 27. Noninvasive Coronary Atherosclerotic Plaque Imaging. JACC. Cardiovascular Imaging. 2023. Kwiecinski J, Tzolos E, Williams MC, et al.Review 28. Computed Tomography Angiography Versus Agatston Score for Diagnosis of Coronary Artery Disease in Patients With Stable Chest Pain: Individual Patient Data Meta-Analysis of the International COME-CCT Consortium. European Radiology. 2022. Wieske V, Walther M, Dubourg B, et al.SR 29. Association of Coronary Artery Calcium Score With Qualitatively and Quantitatively Assessed Adverse Plaque on Coronary CT Angiography in the SCOT-HEART Trial. European Heart Journal. Cardiovascular Imaging. 2022. Osborne-Grinter M, Kwiecinski J, Doris M, et al.Clinical Trial 30. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD. JACC. Cardiovascular Imaging. 2024. Nurmohamed NS, Bom MJ, Jukema RA, et al.Observational 31. The Lancet Commission on Rethinking Coronary Artery Disease: Moving From Ischemia to Atheroma. Lancet. 2025. Zaman S, Wasfy JH, Kapil V, et al.Review 32. Efficacy and safety of novel lipoprotein(a)‐targeted therapies: A systematic review and meta‐analysis of randomized controlled trials. Diabetes, Obesity & Metabolism. 2026. Santana AUL, Yusufzai MO, Freitas APS, et al. Recent Opinion

Send us Fan MailLongevity is everywhere right now—but aging well isn't simply about adding more years to your life. It's about protecting your strength, energy, brain health, metabolic health, and ability to fully participate in the life you love.In this episode of It's Hertime, Cody is joined by Dr. Jennifer Timmons, MD, a longevity physician and the Founder and Medical Director of Timmons Wellness. Dr. Timmons combines traditional primary care, functional medicine, precision testing, and longevity medicine to help her patients extend not only their lifespan, but their healthspan.Together, they explore what actually happens inside a woman's body as she ages—and why menopause may be one of the most important longevity transitions of her life.Dr. Timmons explains how declining estrogen can influence cardiovascular health, bone density, muscle mass, metabolism, brain health, and immune resilience. They also discuss the biological systems that help determine how well we age, including mitochondrial function, metabolic flexibility, inflammation, hormonal communication, and muscle.This conversation goes beyond expensive biohacks and complicated wellness routines. It's about understanding which foundational habits, health screenings, biomarkers, and personalized decisions can help your body continue to adapt, recover, repair, and support the life you want to live.In this episode, we cover:• The difference between lifespan and healthspan• What healthy aging actually looks like inside the body• Why menopause is an important longevity transition• How estrogen affects the brain, heart, bones, muscles, metabolism, and immune system• What separates a vibrant 75-year-old from someone struggling at 55• Why muscle is one of the most important organs for women's longevity• How chronic stress affects hormones, repair, recovery, and metabolic health• The roles of mitochondrial health, inflammation, and metabolic flexibility• How genetics, lifestyle, environment, and hormones influence aging• Important longevity biomarkers, including ApoB, lipoprotein(a), fasting insulin, and hs-CRP• What DEXA scans, coronary calcium scores, grip strength, and VO₂ max can reveal• Which longevity tests may be useful—and which may be oversold• What biohacking gets right and where it can become unnecessarily complicated• Why the fundamentals still matter more than any supplement, wearable, peptide, or wellness trend• The choices women can begin making today to support a longer, stronger, and healthier lifeAging isn't something we need to fear. It's something we can thoughtfully prepare for.The choices we make today help shape not only how long we live, but how strong, capable, connected, and fully alive we feel throughout those years.CONNECT WITH DR. JENNIFER TIMMONS:Website: https://timmonswellnessmd.com/Instagram: https://www.instagram.com/jennifertimmonsmd/CONNECT WITH CODY:Instagram: https://www.instagram.com/codyjeansanders/Learn more about personalized hormone and peptide support:https://www.lyvcare.com/partners/codysandersFollow Mixhers:https://www.instagram.com/mixhers/If this conversation encouraged you, share it with a woman you love. Be sure to follow It's Hertime, leave a review, and join us next week as we continue helping women build healthier, happier, and more colorful lives—one conversation at a time.This episode is for educational purposes only and is not intended to diagnose, treat, prevent, or replace individualized medical care.Did you learn something new today? Be sure to subscribe to this podcast and share this episode with all the girls you love. We would appreciate it if you'd also leave us a rating and review on iTunes.Want to join our Mixhers Girl community and keep this conversation going? We'd love to hear your thoughts, feelings and experiences! Join us HERE!Join Mixhers email list and be the first to have access to new products and be the girl in the know!Follow Cody Instagram:@codyjeansanders

Send us Fan MailControlled human feeding trials show added fructose raises liver fat, triglycerides, uric acid, and insulin resistance at real-world doses.TOPICS DISCUSSED:Glucose vs Fructose in the Liver: Glucose and fructose are handled by the liver in distinct ways.Natural Sugars vs Processed Sugars: Whole fruit is mostly water, fiber, and micronutrients at modest sugar density; cookies and sodas pack far more sugar per weight and are easier to overconsume.HFCS on Store Shelves: Industry cites 55% fructose for beverages, but independent assays of sodas often land higher (around 60% on average, up to ~68%) with no tight standard of identity.Sucrose vs HFCS: In head-to-head controlled feeding, matched-calorie sucrose (~50/50) and HFCS (55/45) moved risk factors similarly versus an aspartame control; total dose mattered more than that small ratio gap.Dose Response: At roughly 10%, 17.5%, and 25% of energy as HFCS beverages, LDL, triglycerides, apoB, uric acid, liver fat, and insulin sensitivity worsen in a dose-dependent way.Fructose vs Glucose Beverages (10 Weeks): Fructose—not matched glucose—raised 24-h uric acid, RBP-4, and other biomarkers in overweight/obese adults.Fructose × Glucose Interaction: In some comparisons, HFCS raised LDL/apoB more than fructose alone, consistent with glucose amplifying the lipid signal.Orange Juice vs Sucrose Beverage: On a fully provided diet, both raised apoB/LDL/postprandial triglycerides even with slight weight loss; OJ lowered uric acid while sucrose did not.Support the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

Hälsoveckan by Tyngre diskuterar den här veckan effekten av tre olika dieter när man har bra koll på kaloriintaget. Studien som diskuteras har jämfört ketogen kost, lågfettkost och medelhavskost i ganska kontrollerande förhållande där deltagarna först fick tappa vikt och sen höll man deltagarnas nya vikt stabil i några veckor för att slutligen göra en rad hälsotester. Resultatet visade på positiva hälsoeffekter från alla dieter men om något så var det små förbättringar för den ketogena dieten jämfört med de andra två. På vissa tester tenderade även medelhavskosten att dra det längsta strået. Studien är riktigt bra utförd för att vara en dietstudie men tyvärr var antalet deltagare i de tre grupperna få vilket gör att det är svårt att veta hur stor vikt man ska lägga vid olika delar. Studien i fråga heter, Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial. På Hälsoveckan by Tyngres instagram kan du hitta bilder relaterat till detta och tidigare avsnitt. Hålltider (00:00:00) Introsnack (00:01:32) Vegankost, medelhavskost eller keto för viktnedgång och sen viktstabilitet (00:13:20) Mindre leverfett med ketogen kost (00:16:41) Ingen skillnad i LDL och ApoB trots stora skillnader i intag mättat fett och kolesterol (00:23:52) Andra typer av ketogen kost brukar ge lite sämre LDL än andra dieter

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Michael Davidson is a world-renowned cardiologist, lipidologist, and the founding CEO of NewAmsterdam Pharma. He begins this episode by sharing how his family history shaped his interest in lipidology and primary prevention. He explains why prevention should focus on causal drivers of disease rather than near-term risk and examines the causal relationship between LDL and atherosclerotic cardiovascular disease. Michael then traces the complicated history of CETP inhibitors—from the original rationale that raising HDL would reduce cardiovascular risk to the failures of torcetrapib, dalcetrapib, and evacetrapib—and explains how lessons from these trials ultimately led to the development of obicetrapib. He reviews the phase 2 and phase 3 trials of obicetrapib, its effects on LDL-C, apoB, LDL particle number, and Lp(a), the ongoing cardiovascular outcomes trial, and where the drug could fit alongside statins and other lipid-lowering therapies. Peter and Michael discuss the relationship between statins and diabetes risk, then turn to the potential role of obicetrapib in Alzheimer's disease prevention, exploring the genetics of APOE4 and CETP, cholesterol metabolism within the brain, and emerging biomarker data. Finally, Peter and Michael explore the benefits of omega-3 fatty acids and the challenge of delivering DHA to the brain, as well as ongoing work on klotho in preparation for clinical trials. They discuss the potential for AI to transform clinical trials and the scientific and financial challenges of developing new therapies for cardiovascular and neurodegenerative disease. We discuss: Michael's path to lipidology, and his passion for primary prevention [3:30]; Reframing prevention around causal drivers rather than time horizon [9:30]; What CETP inhibition does, the evolutionary biology of CETP, the HDL-raising rationale, and Pfizer's torcetrapib failure [15:00]; Why raising HDL is thought to be beneficial, a quick review of the functions of HDL, and how this connects to torcetrapib [24:00]; The graveyard of CETP inhibitors: Roche's dalcetrapib, Lilly's evacetrapib, and Merck's REVEAL trial [27:15]; The causality of LDL in cardiovascular disease [34:30]; Reviving obicetrapib at NewAmsterdam, and confirming the benefit is LDL lowering: the TULIP data, the abandoned statin-intolerance path, and the Mendelian randomization verdict on HDL [37:30]; Phase 2 and phase 3 trials of obicetrapib—ROSE, BROOKLYN, BROADWAY, and TANDEM—and the PREVAIL outcomes trial, with the European and US approval paths [44:45]; Discordance among LDL-C, LDL-P, and apoB with CETP inhibition, and obicetrapib's Lp(a)-lowering effect [50:30]; Where obicetrapib fits in the lipid-lowering toolkit, the case against high-dose statins, and the problem of drug pricing [57:30]; The case for obicetrapib in Alzheimer's: the APOE4 and CETP genetics, the animal models, and funding Alzheimer's research [1:03:45]; Brain cholesterol metabolism and the APOE4 mechanism: the blood-brain barrier, astrocyte cholesterol efflux, the amyloid-tau cascade, the role of HDL, and why statins don't cause Alzheimer's disease [1:08:00]; The biomarker evidence: the CSF pilot study, Alzheimer's as a disease of middle age, the pharma graveyard problem, and the p-tau 217 results from BROADWAY [1:17:45]; Whether obicetrapib translates into clinical benefit for Alzheimer's disease: the risk of fooling yourself, the persistence of the amyloid dogma, ARIA in APOE4 homozygotes, and the next prevention trial [1:28:00]; Fish oil, EPA, and DHA: the cardiovascular trials and the challenge of delivering DHA to the brain [1:32:00]; Two open problems: using AI to reform clinical trials, and the statin–diabetes signal [1:41:15]; What it takes to develop a drug, the biotech investment landscape, and the klotho program [1:48:15]; Closing reflections: what to do if you carry APOE4, balancing motivation against over-testing, and the need for multiple therapies [1:55:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Anthony G. Jay, Ph.D., is a biochemist, researcher, bestselling author, and founder of AJ Consulting Company. His research background spans fats, hormones, cholesterol, genetics, epigenetics, stem cells, and infrared light, including work with the U.S. Department of Veterans Affairs and Mayo Clinic. Today, Dr. Jay combines his scientific expertise with public speaking and writing, exploring topics at the intersection of biology, health, and human performance. He and his wife homeschool their five children. In this episode, Dr. Brian and Dr. Jay talk about… (00:00) Intro (00:54) Biology and theology (03:54) The highest risk factor for heart disease (05:43) Plaque reversal (08:34) Statins and diabetes risk (14:45) LDL and heart disease (22:35) Connecting insulin resistance and heart disease (25:44) How corruption is keeping harmful medical narratives afloat (34:41) Covid coverups (37:28) How to avoid bias information in the heart disease space (51:40) LPA (55:07) ApoB (01:01:34) Plaque stabilization and reversal (01:06:35) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Dr. Anthony Jay: X: https://x.com/anthonygjay Website: https://www.ajconsultingcompany.com Sugar Beat (new book!): https://www.amazon.com/Sugar-Beat-CHOLESTEROL-Destroys-REVERSING-ebook/dp/B0H9QN2BL9?ref_=ast_author_mpb Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

You exercise. You eat well. You feel great. Your blood work comes back “normal.” So why are seemingly healthy people still having heart attacks?Cardiologist Dr. Jack Wolfson is back on Crackin' Backs—and this conversation challenges some of the assumptions many of us have about what it actually means to be heart healthy.Wolfson argues that a standard cholesterol panel may be only a small part of the cardiovascular picture. His approach looks deeper at markers such as ApoB, Lp(a), inflammation, homocysteine, omega-3 status, metabolic health and other factors when assessing cardiovascular risk. But that's only where the conversation starts.We get into some of today's most debated heart-health questions:Can you have “normal” cholesterol and still be at risk? What do ApoB and Lp(a) actually tell us? Are statins being prescribed too aggressively—or are they saving lives? Does a coronary calcium score of zero really mean you're safe?  What does Wolfson think about GLP-1 drugs and their cardiovascular benefits?  Could COVID or post-COVID dysautonomia/POTS have lasting cardiovascular implications?  Why can someone be lean, athletic and incredibly fit—and still have a heart attack? And what should you actually be testing if your goal isn't simply to avoid disease—but to protect your heart for decades? Wolfson doesn't shy away from controversy. He questions conventional approaches to statins and coronary calcium testing, discusses where he believes mainstream cardiology falls short, and explains why he favors a much broader, root-cause approach to cardiovascular risk.  And one of the most surprising moments has nothing to do with cholesterol:Could something as simple as when you go to bed affect your heart-attack risk? Wolfson discusses research linking inconsistent sleep timing with cardiovascular risk—and what that might mean for your daily routine. This isn't about creating fear.It's about asking a better question:If you feel healthy today, how do you know your heart actually is?Watch to the end, then tell us in the comments:What's the ONE heart-health number or test you think everyone over 40 should know?

A red flag next to your LDL number can feel alarming, but LDL is only one part of a much larger cardiovascular risk picture. In this episode of Metabolic Mind, cardiologist and lipidologist Dr. Bret Scher explains how to read a cholesterol panel with more context and less fear.Dr. Scher walks through LDL, triglycerides, HDL, non-HDL cholesterol, ApoB, Lp(a), and the triglyceride-to-HDL ratio. He also explains how the 2026 cholesterol guidelines use the PREVENT risk calculator, where LDL targets currently stand, and why individual risk factors, metabolic health, family history, and direct measures of vascular disease can change the conversation.He covers:Why LDL should not be read in isolationWhat triglycerides and HDL can reveal about metabolic healthWhy Dr. Scher pays attention to the triglyceride-to-HDL ratioWhen LDL above 190 may raise concern for familial hypercholesterolemiaWhy Lp(a) should be measured at least once in adulthoodHow ApoB differs from LDL cholesterolWhat the PREVENT risk calculator includesHow coronary calcium scans and CT angiograms act as tools that may help refine riskWhy LDL targets vary by risk categoryWhy metabolic health, insulin resistance, and individual preferences and priorities should be part of the discussionA cholesterol panel can start a thoughtful conversation with your healthcare provider. One number rarely tells the whole story, and better decisions come from looking at the full cardiometabolic picture.

Heart disease is often treated like something women need to start thinking about later in life, but what if some of the earliest clues about your cardiovascular risk appeared decades earlier — during pregnancy? In this episode of Confessions of a Male Gynecologist, Dr. Shawn Tassone sits down with cardiologist Dr. Abeer Berry for a wide-ranging conversation about women's heart health, menopause, cholesterol, cardiovascular risk, and some of the most persistent heart-health misinformation circulating online. One of the most important takeaways: a woman's reproductive history is part of her cardiovascular history. Pregnancy places significant stress on the cardiovascular and metabolic systems. Conditions such as preeclampsia, gestational hypertension, gestational diabetes, and delivering a baby who is small for gestational age can become important pieces of the cardiovascular risk conversation years later. Then comes another major transition: menopause. Dr. Tassone and Dr. Berry discuss how changing estrogen levels intersect with blood pressure, cholesterol, metabolism, and cardiovascular risk and why menopause, hormone therapy, and heart health shouldn't automatically be treated as separate conversations. But the discussion goes much further than hormones. They tackle one of the biggest debates currently happening in the wellness space: Does LDL cholesterol actually cause atherosclerosis — or is cholesterol being unfairly blamed? Dr. Berry breaks down LDL cholesterol, inflammation, ApoB, lipoprotein(a), HDL, triglycerides, and why particle size doesn't necessarily tell the story people on social media claim it does. They also discuss statins and the growing amount of misinformation surrounding cholesterol-lowering medications, including claims that statins barely extend life, cause dementia, or are prescribed simply because pharmaceutical companies want to sell more medication. You'll also hear an important conversation about coronary artery calcium scoring — including why a CAC score of zero doesn't necessarily mean you have zero cardiovascular risk, the difference between calcified and soft plaque, and how calcium scores can influence conversations around treatment. In This Episode, You Will Learn: • Why heart disease risk in women is often underestimated • Pregnancy as a cardiovascular and metabolic "stress test" • Preeclampsia, gestational hypertension, and future heart health • Gestational diabetes and long-term cardiovascular risk • Why reproductive history still matters decades after pregnancy • Menopause, estrogen, and cardiovascular health • Hormone replacement therapy in women with cardiovascular risk factors • Whether LDL cholesterol actually causes atherosclerosis • LDL-C vs. ApoB and what each measurement tells you • What lipoprotein(a), or Lp(a), can reveal about inherited cardiovascular risk • Why extremely high HDL isn't necessarily protective • Triglycerides and metabolic health • Statin myths and misinformation on social media • Why a coronary calcium score of zero doesn't tell the entire story • Soft plaque vs. calcified plaque • When lipid-lowering therapy may involve more than statins • The cardiovascular numbers women should know • Why high blood pressure can go unnoticed • Heart attack symptoms in women • Why women's healthcare needs to look at the whole medical history, not individual systems in isolation This conversation is about more than cholesterol numbers or whether someone should take a statin. It's about understanding cardiovascular risk across a woman's entire lifetime — from pregnancy through menopause and beyond. Because sometimes the information that matters at 50 was already beginning to show itself at 30. Subscribe for weekly conversations about women's health, hormones, menopause, evidence-based medicine, and the topics women deserve to understand more fully. Episode Resources: Work with Dr. Tassone | Tassone Advanced Gynecology Please contact the clinic directly at (512) 956- 0296 with all scheduling inquiries. Purchase Dr. Tassone's Best-Selling Book | The Hormone Balance Bible Dr. Tassone's Integrative Hormonal Archetype Quiz | Discover Your Hormonal Archetype Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.

Ever wonder why your cholesterol climbs after you clean up your diet, or why your doctor calls your creatinine a kidney problem?In this video, I share the highlights from my two hour live Q&A at the Animal Based Gathering in Costa Rica — ApoB and metabolic health, honey versus processed sugar, thyroid and testosterone as the check engine light, peptides, NAD, medical education, and being a conduit for something bigger.--- --- ---0:00 Intro0:43 ABNRF and Community4:14 Research Projects6:33 ApoB and Cholesterol8:22 Seed Oils and Linoleic Acid11:13 Why Saturated Fat Raises ApoB14:08 Keto, High LDL, Keto CTA16:59 Interpreting Your Labs19:58 Honey Versus Sugar25:10 Honey as Medicine Carrier27:46 Creatine and Creatinine33:12 Training With Limited Time35:46 Exercise Is for Your Brain38:48 Running Form and Heel Striking41:45 Testosterone as Check Engine Light46:30 Thyroid Labs and Iodine54:14 Peptides and GLP-1s55:49 Satiety and Processed Food1:03:11 BPC-157, Melanotan, NAD1:08:06 Doctors, Bloodwork, Sleep, Light1:15:22 Gorillas, AI, Being Human1:18:41 Randle Cycle and Consistency1:24:31 Finding Purpose1:26:49 Rebuilding Medical School1:32:53 Food Combining--- --- ---https://pubmed.ncbi.nlm.nih.gov/27071971/https://pubmed.ncbi.nlm.nih.gov/36379223/https://pubmed.ncbi.nlm.nih.gov/31105044/https://pubmed.ncbi.nlm.nih.gov/35441470/https://pubmed.ncbi.nlm.nih.gov/25071023/https://pubmed.ncbi.nlm.nih.gov/21367944/https://pubmed.ncbi.nlm.nih.gov/20111000/https://pubmed.ncbi.nlm.nih.gov/35286195/https://pubmed.ncbi.nlm.nih.gov/8432867/https://pubmed.ncbi.nlm.nih.gov/38418482/https://pubmed.ncbi.nlm.nih.gov/33471045/

On the Evolving Wellness podcast, host Sarah interviews returning guest Dr. Anthony Jay (PhD biochemistry; former Mayo Clinic researcher) about his book Sugar Beat: How Sugar, Not Cholesterol, Destroys Arteries and his broader critique of mainstream cardiology. Jay cites a 28,000-person study where insulin resistance had the highest heart-attack hazard ratio (6.4) versus hypertension (2.2), triglycerides (2.1), and LDL (1.38), arguing doctors overemphasize cholesterol while neglecting insulin and HOMA-IR. He claims statins increase arterial calcification and diabetes risk, criticizes organizations like the American Heart Association, and disputes fears around LDL, ApoB, and Lp(a), describing them as fat-transport/oxidation-related. Jay recommends focusing on metabolic health, diet and fasting to promote fat burning and plaque reversal, cautions about processed foods and mislabeled oils, discusses CAC vs CCTA imaging variability, and notes genetic nuances such as iron-related risk and sitosterolemia.— Connect with Dr. Anthony Jaywebsite - https://www.ajconsultingcompany.com/YT - https://www.youtube.com/@dranthonyjay Books:Sugar Beat - https://amzlink.to/az0hIdy8AMV03Estrogeneration:  https://amzlink.to/az0U0rLUAUr8f _________Sponsored By:→ Bon Charge | Go to https://boncharge.com/products/demi-red-light-device?rfsn=8108115.26608d & use code SARAHKLEINER for 15% off storewide._________Timestamp:00:00 Insulin Resistance vs LDL01:05 Meet Dr Anthony Jay04:03 Censorship and Free Speech10:14 Seed Oils and Food Fraud14:04 Statins and Calcified Plaque21:53 Sugar Beat Heart Disease Mechanism30:59 Saturated Fat Genes and Lp a40:52 Sleep Stress Insulin Link42:14 Metabolic Flexibility Basics42:55 Genetic High Cholesterol Cases43:40 Oreo Study LDL Trap45:45 Statins Guidelines Corruption51:02 CAC vs CCTA Scans57:04 Labs Genes Wrap Up——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free -  https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter delves into the critical subject of blood pressure, which is one of the three primary causes of atherosclerosis, along with high apoB and smoking. He begins by unraveling the nature of high blood pressure, its prevalence, and why it often goes undiagnosed. Peter describes in detail the proper way to accurately measure blood pressure and what determines a diagnosis. Next, Peter discusses the actionable steps one can take in response to high blood pressure, shedding light on the extent to which factors like weight loss, exercise, and nutrition can make an impact. He also explores the pharmacological options available and offers valuable insights on how to approach them. We discuss: Blood pressure and other risk factors for cardiovascular disease [2:30]; Defining blood pressure and the purpose and meaning of a blood pressure measurement [5:45]; The implications of high blood pressure and the importance of maintaining an optimal level [10:30]; The importance of accurate measurements of blood pressure and how Peter approaches the care of patients at the very top range of "normal" [21:45]; The prevalence of high blood pressure—a hidden epidemic? [24:30]; The consequences of high blood pressure on cardiovascular health, brain health, kidneys, and more [24:45]; Low blood pressure: symptoms and consequences [35:30]; How to properly measure blood pressure [37:45]; Daily variance in blood pressure and the transient changes in blood pressure during exercise [48:00]; Primary hypertension vs. secondary hypertension: what to look for [51:45]; Lifestyle factors impacting blood pressure: weight loss, exercise, and sodium [57:45]; Impact of insulin resistance and type 2 diabetes on blood pressure [1:04:45]; How sleep impacts blood pressure [1:06:45]; Pharmacologic options for managing blood pressure [1:08:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Kleine Korrektur: Bei Minute 4 und 15 Sekunden ist ein Versprecher und es heißt eigentlich bei 100 Milligramm pro Deziliter.Cholesterin ist nicht der Feind, aber es lohnt sich, genauer hinzuschauen. In dieser Folge erkläre ich dir, welche Blutwerte wirklich zählen, wenn es um dein Cholesterin geht, wie sie zusammenhängen, in welchem Referenz- und Optimalbereich sie liegen sollten, und warum Statine auf Dauer für manche Menschen sogar mehr Probleme schaffen können, als sie lösen.Was dich in dieser Folge erwartet:- Was LDL, HDL und Triglyceride wirklich bedeuten, mit konkreten Referenz- und Optimalwerten- Warum ApoB oft aussagekräftiger ist als das klassische LDL, und wo der Zielbereich liegt- Was Lp(a) ist und warum du ihn mindestens einmal im Leben testen lassen solltest- Warum extrem hohes HDL nicht automatisch gut ist- Warum Statine Coenzym Q10 senken, Lp(a) paradoxerweise erhöhen können, und mit Insulinresistenz in Verbindung gebracht werden- Welche Lebensstilfaktoren den größten Hebel auf deine Werte haben✨Unverbindliche Sprechstunde

For decades, "high cholesterol" has been treated as a diagnosis in itself - but Dr. Barrett breaks down why that's outdated thinking. Using advanced lab markers now available through services like Function Health, he walks through five common cholesterol myths: that high cholesterol equals heart disease, that LDL-C tells the whole story, that high HDL is automatically protective, that diet alone drives your LDL levels, and that a normal total cholesterol means low risk. He explains where ApoB, LPA, and insulin resistance fit into a modern cardiovascular risk model - and the three tests he recommends everyone over 30 get checked.. . . Watch the episode on YouTube here! Click here to view the episode transcript! Podcast Team Dr. Barrett Deubert - Host Grant Crenshaw - Editor (00:00) - Intro (01:14) - High Cholesterol = Heart Disease? (03:17) - LDL-C vs ApoB? (07:08) - High HDL Protects You? (09:12) - Diet Alone Determines LDL? (12:53) - Normal Cholesterol = Low Risk? (15:22) - Omega-3s & Cardiovascular Risk (17:17) - 5 Truth Statements (18:30) - Closing Thoughts DISCLAIMERThis content is strictly the opinion of Dr. Barrett Deubert and is for informational and educational purposes only. It is not intended to provide medical advice or to replace medical advice or treatment from a physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding health questions and concerns. Neither Dr. Deubert nor the Real Health Co. takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All audience members, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.

A low dose of tirzepatide, taken purely to move the needle on cholesterol, turned out to move a lot more than that. In this episode, Jeff sits down again with Dr. Robin Berzin, founder of Parsley Health, to go through his bloodwork and an unexpected side effect: a blunting of desire that shows up in his coffee, his cocktails, and his ambition. Why losing your appetite for food can also mean losing it for coffee, alcohol, and sex What the dopamine and serotonin circuitry are actually doing on a GLP-1 The line between healthy desire and maladaptive craving, and where these drugs land on it Why some people feel liberated when "food noise" disappears, and others feel flattened What Jeff's ApoB and LDL numbers say about who these drugs actually help This episode is for anyone on a GLP-1 or weighing one, and anyone curious what these drugs are doing beyond the scale. This episode was made possible by: LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at ⁠drinklmnt.com/commune⁠. Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 20% off your order at ⁠vivobarefoot.com/commune⁠. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/commune. CocoaVia: Use code COMMUNE2026 for 25% off at CocoaVia.com

In Episode 299 of the Fit Father Project Podcast, Dr. Anthony Balduzzi steps away from the usual guest format to do something different — and personal.As the show approaches its 300th episode, Dr. A sits down solo to share 10 of the most powerful physical health and longevity lessons he's learned over 15 years building the Fit Father and Fit Mother communities.This is part one of a two-part series, covering the training, nutrition, sleep, and recovery insights that have shaped his own evolving approach to staying strong for life.Part two — covering mindset, relationships, and fulfillment — drops next episode.From why explosive "speed training" may be the most overlooked key to staying young, to why nutrient density matters more than macros once your basics are dialed in, to the deep-cleaning protocols he personally uses once or twice a year — this episode is a masterclass in what actually moves the needle after 40.Rate & Review — If this episode gave you something new to think about, please take a moment to rate and review the Fit Father Project Podcast. Your review helps more busy dads discover practical, science-backed health conversations that can genuinely change their lives.Join the Fit Father Project Community — If you're ready to put these lessons into action with support, accountability, and a brotherhood of men committed to thriving after 40, come join us. We're here to help you build real, lasting health together.Key TakeawaysMove fast or get old — fast-twitch motor units decline starting in your 30s-40s and accelerate in your 50s-60s; explosive training (sprints, plyometrics, assault bike intervals) is what keeps your nervous system young and prevents the falls that come with aging.Adaptability is the keystone of longevity training — what worked in your 30s won't work the same in your 50s and beyond; the goal is progressively joint-friendly, sustainable movement (dumbbells, kettlebells, calisthenics) you can do for life."Eustress" is the name of the game — good stress (lifting, sprinting, fasting, even polyphenols in blueberries) is what signals your body to adapt and grow stronger; the moment you stop applying it is the moment decline accelerates.Macros are level one, nutrient density is level two — once your protein, carbs, and fats are dialed in, the next upgrade is prioritizing micronutrient-dense foods like organ meats, egg yolks, salmon, cruciferous veggies, berries, and colorful carbs.Clean water is the basis of life — municipal tap water and plastic bottles introduce chlorine byproducts, heavy metals, and microplastics; whole-home filtration plus reverse osmosis water (with minerals added back in) is a foundational health upgrade.Cleanse your body once or twice a year — like deep-cleaning your house or car, periodic multi-day fasts or juice cleanses help clear your "total body burden" of heavy metals, plastics, and other accumulated toxins.Sleep is your highest-leverage, most under-optimized habit — sleep regulates inflammation, hormones, and recovery more than any workout; under-sleeping is the fastest path to overtraining, anxiety, and low motivation.Circadian rhythm and nature connection drive recovery — morning sunlight, blue-light blocking at night, and grounding your feet on the earth all measurably reduce inflammation and improve energy.Don't guess, test — get advanced labs (vitamin D3, full thyroid panel, ApoB, hs-CRP, microbiome testing) instead of relying on how you feel; objective data catches deficiencies you'd never notice otherwise.Injuries are part of the process, not the end of it — every setback (Dr. A has broken his arm five times and had seven leg reconstructions) is an opportunity to learn your body deeper and come back stronger; staying in the game long-term is what actually matters.10 Health Lessons From 15 Years Building Fit Father & Fit Mother (Ep. 299)Want To Change Your Life? Check Out FF30X!FF30X is a simple, sustainable, and specific weight loss program designed especially for busy men over 40.With short metabolic workouts, an easy-to-follow meal plan, and an accountability team there for you every step of the way, FF30X can help you lose weight, regain energy and vitality, and live life to the fullest. Click here to see everything you get when you join FF30X.After watching his own Dad lose his health and pass away at the young age of 42, Dr. Balduzzi founded The Fit Father Project and Fit Mother Project to help busy dads and moms get and stay healthy for their families.Dr. Anthony Balduzzi holds dual degrees in Psychology & Nutrition from the University of Pennsylvania, a Doctorate of Naturopathic Medicine, and is also a former national champion bodybuilder.He's most proud of the fact that he's helped over 60,000 parents in 125+ countries lose weight and get healthy for life.Please know that weight loss results and health changes/improvements vary individually; you may not achieve similar results. Always consult with your doctor before making health decisions. This is not medical advice – simply very well-researched information on longevity training, muscle health, and healthy aging.

Listen in as our expert panel breaks down what clinicians need to know about the 2026 dyslipidemia guidelines, such as the role of lipoprotein a, apolipoprotein B, and coronary artery calcium scoring. Plus, you'll walk away with practical takeaways to optimize lipid management including when to add non-statin therapies like PCSK9 inhibitors and ezetimibe for your patients.Special guests:Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLAExecutive Director, Ambulatory Pharmacy ServicesGrady Health SystemJoel C. Marrs, PharmD, MPH, BCACP, BCCP, BCPS, CLS, FAHA, FASHP, FCCP, FNLACardiology Ambulatory Clinical PharmacistCheyenne Regional Medical Group Heart & Vascular InstituteAdjoint Associate ProfessorUniversity of Colorado School of MedicineYou'll also hear practical advice from panelists on TRC's Editorial Advisory Board:Stephen Carek, MD, CAQSM, DipABLMClinical Associate Professor of Family MedicinePrisma Health/USC-SOMG Family Medicine Residency ProgramUSC School of Medicine GreenvilleAndrea Darby-Stewart, MDAssociate Director, Honor Health Family Medicine Residency ProgramClinical Professor of Family, Community & Occupational MedicineThe University of Arizona College of Medicine - PhoenixCraig D. Williams, PharmD, FNLA, BCPSClinical Professor of Pharmacy PracticeOregon Health and Science UniversityFor the purposes of disclosure, Dr. Cheeley reports relevant financial relationships with [lipids] Novartis, Regeneron (honorarium). The other speakers have nothing to disclose.  All relevant financial relationships have been mitigated.This podcast is an excerpt from one of TRC's monthly live CE webinars, the full webinar originally aired in July 2026.

Welcome to SEASON SEVEN, Superwomen!  I'm so excited to be back in your listening ears, and I'm truly pumped for what this season is going to look like. This podcast started in 2019, pulled us all through the last seven years, and we are now entering the 147th episode, in the seventh season. Holy cow!  Today on the podcast, I'm asking a very important question... "What if your periods could give us clues about the health you'll need to protect ten, twenty or thirty years from now — even if there was never anything "wrong" with them?" We'll explore why hormone and reproductive health belong in the preventative-health conversation. We look at what menstrual cycles, pregnancy history, PCOS, perimenopause and menopause can tell us about cardiovascular health, metabolic health, body composition, bone and healthspan. But this isn't an episode about looking for hormone problems. A normal menstrual history is information. An uncomplicated pregnancy is information. The timing and pattern of perimenopause are information too. We'll look at how reproductive history can help us understand health trajectory earlier — and why something doesn't have to be wrong before it becomes useful information. Hormones are data, not destiny. The goal is to use that data to build better preventative-health plans long before we're treating the outcomes we're trying to prevent. RESEARCH USED IN THIS EPISODE Global Healthspan-Lifespan Gaps Among 183 WHO Member States — Garmany & Terzic, JAMA Network Open, 2024. This is the study behind the discussion that women have a wider healthspan-lifespan gap than men. JAMA Network Open full article | PubMed Menstrual Cycle Regularity and Length Across the Reproductive Lifespan and Risk of Cardiovascular Disease — Wang et al., JAMA Network Open, 2022; 80,630 women followed for 24 years. JAMA Network Open full article | PubMed Menstrual Cycle Regularity and Length Across the Reproductive Lifespan and Risk of Premature Mortality — Wang et al., BMJ, 2020; 79,505 women followed prospectively. PubMed Association Between Reproductive Life Span and Incident Nonfatal Cardiovascular Disease — Mishra et al., JAMA Cardiology, 2020; pooled data from 307,855 women. JAMA Cardiology full article | PubMed Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women — American Heart Association Scientific Statement, Circulation, 2021. PubMed Gestational Diabetes and the Risk of Cardiovascular Disease in Women: A Systematic Review and Meta-analysis — Kramer et al., Diabetologia, 2019; more than 5.3 million women. PubMed Hypertensive Disorders of Pregnancy and Risk of Cardiovascular Disease-Related Morbidity and Mortality — systematic review/meta-analysis involving more than 13 million women. PubMed Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention — American Heart Association Scientific Statement, Circulation, 2020. This is one of the most important papers supporting the episode's preventative-health framing of perimenopause. PubMed Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition? — SWAN; Matthews et al., JACC. The study separating age-related changes from menopause-associated changes in LDL, total cholesterol and ApoB. PubMed Changes in Body Composition and Weight During the Menopause Transition — SWAN; Greendale et al., 2019. Fat gain accelerated and lean mass declined around the menopause transition without a corresponding acceleration in overall weight gain. PubMed Abdominal Visceral Adipose Tissue Over the Menopause Transition and Carotid Atherosclerosis — SWAN Heart Study, 2021. PubMed Bone Mineral Density Loss in Relation to the Final Menstrual Period — SWAN; Greendale et al., 2012. The research behind our discussion of the accelerated bone-loss window around menopause. PubMed

In this episode, Dr. David Jockers breaks down the science behind five simple drinks that clear your arteries, reduce inflammation, and support long-term cardiovascular health, walking through the human research behind each one and giving you the exact recipe to make it at home.   You will learn why arterial inflammation, not age or cholesterol, is the real driver behind clogged arteries, and how these five drinks work to reduce visceral fat, improve insulin sensitivity, lower inflammatory markers like CRP and ApoB, and support nitric oxide production and arterial repair. Dr. Jockers also shares a simple 30-day rotation plan for weaving these drinks into your daily routine.   In This Episode:  00:00 Chocolate Myth Busted 00:13 Episode Setup and Reviews 01:00 Health Coaching Offer 03:52 Why Arteries Clog 05:37 Drink 1 Pomegranate Elixir 08:06 Drink 2 Turmeric Coffee 12:30 Drink 3 Olive Oil Shot 16:15 Drink 4 ACV Cinnamon Shot 18:53 Drink 5 Cacao Hot Chocolate 22:47 30 Day Rotation Plan 24:41 Wrap Up and Outro   Discover clinically inspired, clean skincare trusted by over 60,000 women and featured in outlets like Elle and Cosmopolitan. Pureance offers advanced formulas like Cellular Restore Serum with bakuchiol, deep-hydration Tremella Mushroom Serum, Lift & Glow Eye Cream, and Even Glow Serum powered by Kakadu plum. For a limited time, get 35% off your entire order when you shop at Pureance.com and use promo code JOCKERS at checkout. n oranges. Go to Pureance.com and enter code JOCKERS at checkout for 35% off your order today. Head to beamminerals.com/DRJOCKERS and use code DRJOCKERS for 20% off your first order. Give BEAM Minerals a try and discover why mineral replenishment could be the missing piece in your wellness routine. Get 20% off your first order at beamminerals.com/DRJOCKERS with code DRJOCKERS.   "Visceral fat chokes off blood supply to your vital organs like your liver and your heart, and releases inflammatory compounds."  ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean TuneIn Radio     Resources: Visit https://pureance.com and get 35% off with code JOCKERS at checkout. Visit beamminerals.com/DRJOCKERS and use code DRJOCKERS for 20% off     Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Are you tired of being told your labs are "completely normal" even though you feel exhausted, foggy, and run down? In this episode of Delivering Health, Dr. John Neustadt sits down with Dr. Tracy Gapin — a board-certified urologist of over 20 years who hit his own burnout wall at age 40 and transformed his health through functional medicine. Together, they pull back the curtain on conventional medicine's blind spots and explain why standard healthcare is built to manage disease rather than optimize health. Dr. Gapin shares his "Test, Design, Track" framework for precision performance medicine, detailing the hidden constraints — from heavy metals to mold — that can override even the best diet. You'll learn the five blood-testing categories that conventional doctors routinely miss, including why ApoB is a far more accurate cardiovascular predictor than standard cholesterol, and why fasting insulin is an early-warning system for metabolic dysfunction. Whether you're a high-achieving executive feeling the slow drain of chronic pressure, or simply looking to regain mental clarity and physical edge, this conversation offers a practical, science-backed roadmap for taking control of your health. - - - - - About the Guest: Dr. Tracy Gapin is a board-certified urologist with over 20 years of experience in robotic surgery and men's health. After experiencing severe burnout, chronic exhaustion, and weight gain around age 40 — and being told by his own doctor that his standard labs were "perfectly fine" — he shifted his career toward functional medicine, epigenetics, and hormone optimization. Today he is the founder of the Gapin Institute and Peak Launch, where he practices "precision performance medicine" to help executives, entrepreneurs, and high-achievers optimize their physical and cognitive performance. He also trains other physicians to transition into this model through the Peak Launch Institute. - - - - - Social Handles: Instagram: https://www.instagram.com/drtracygapin/?hl=en Website: https://peaklaunch.com Free High Performance Health Handbook: https://peaklaunch.com/guide Peak Launch Institute: https://peaklaunchinstitute.com - - - - - Follow NBI & Dr. John Neustadt, ND: Website: https://nbihealth.com/ Delivering Health Podcast: https://nbihealth.com/podcast-archive Shop NBI Supplements: https://shop.nbihealth.com/ Facebook: https://www.facebook.com/nbihealth/ Instagram: https://www.instagram.com/nbi_health/ X (Twitter): https://x.com/JohnNeustadt LinkedIn: https://www.linkedin.com/in/john-neustadt-nd-1553576/ YouTube: https://youtube.com/user/NBIHealth Shop supplements: https://shop.nbihealth.com/ - - - - - PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/

Welcome to this week's Midlife Minute episode! Statistically, one in three women will die of heart disease. So, today, we're answering some of the many questions I received about lipids and heart health. Although I've done other lipid-focused Midlife Minutes before, this episode is yet another dedicated to Dr. Tom Dayspring, as I've received such a vast number of questions on this particular topic.    IN THIS EPISODE, YOU WILL LEARN: Why understanding your ApoB and Lp(a) is an essential part of assessing your cardiovascular risk Why treatments for lipid abnormalities should be individualized to fit each specific abnormality  Essential lifestyle measures for supporting overall cardiovascular health How CAC scoring, CT coronary angiography, and Clearly AI-assisted imaging differ, what each test measures, and their limitations  How cardiovascular disease can sometimes present differently in women  Why are premature atrial contractions and premature ventricular contractions often benign when the heart is structurally normal? How the roles of statins, ezetimibe, PCSK9 inhibitors, GLP-1 medications, and emerging RNA therapies differ, and why they should not be considered interchangeable How declining estrogen impacts cardiovascular health Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line

Cardiovascular disease remains a leading cause of death, while evolving guidelines and increasingly aggressive LDL cholesterol targets are changing how clinicians approach lipid management. Jodi Martinez, Pharmacist Clinical Specialist in Cardiology at the University of Colorado Hospital, part of UCHealth, joins Kerry Schwarz, Senior Clinical Manager for Evidence Based Medicine and Outcomes with the Vizient Center for Pharmacy Practice Excellence, to explore the emerging role of enlicitide in lipid management. They discuss the evidence behind its approval, its potential to expand patient access and where this first oral PCSK9 inhibitor may fit alongside existing therapies.   Guest Speaker: Dr. Jodi Martinez, Pharm.D., BCPS, BCCP, HF-CERT Pharmacist Clinical Specialist in Cardiology University of Colorado Hospital, UCHealth   Host:  Dr. Kerry Schwarz, Pharm.D., MPH Senior Clinical Manager, Evidence-Based Medicine and Outcomes Vizient Center for Pharmacy Practice Excellence    Show Notes:  [01:26] The limitations of current lipid management and why many high-risk patients still struggle to reach increasingly aggressive LDL cholesterol targets. How cost, prior authorization requirements and step therapy can create barriers to accessing injectable PCSK9 therapies. [03:27] The evidence behind enlicitide and findings from the CORALreef clinical trial supporting its FDA approval. How enlicitide performed across LDL cholesterol, non-HDL cholesterol, ApoB and lipoprotein(a) endpoints, and why cardiovascular outcomes remain an important unanswered question. [06:37] An oral PCSK9 inhibitor could expand access by offering an alternative to specialty injectable therapies. Why retail pharmacy availability, cost and greater prescribing flexibility could help more patients receive intensive lipid lowering therapy. [08:11] The potential barriers to enlicitide adoption, including delays in formulary review, insurance coverage and the administrative burden placed on clinicians. The lack of published cardiovascular outcomes could influence payer coverage, formulary placement and early uptake. [10:15] Station remains the cornerstone of lipid management and where enlicitide may ultimately play a role Clinicians may consider the amount of LDL reduction a patient needs when choosing among available therapies.   Links and Resources: 2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Solution Set Oversight Committee 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines   Subscribe Today! Apple Podcasts Spotify YouTube RSS Feed    

Hvor mye forteller egentlig et høyt kolesteroltall om helsen din? Og hvis to mennesker har samme LDL nivå, har de nødvendigvis samme risiko?Lege Pål Branæs er tilbake hos Biohacking Girls. Han er en stemme vi setter stor pris på fordi han tør å stille kritiske spørsmål, også til etablerte sannheter, samtidig som han er tydelig på at medisiner kan være både nødvendige og livreddende.Vi går inn i et av de mest omdiskuterte områdene innen forebyggende helse: kolesterol, statiner og individuell risiko. Hva er forskjellen på relativ og absolutt risiko? Hvem har størst dokumentert gevinst av statiner, og når er det liten eller ingen gevinst? Hvorfor kan to personer med samme LDL ha helt forskjellig risikobilde? Vi snakker også om ApoB og Lp(a), og Monica deler sin egen historie med høyt Lp(a) og behandling med PCSK9-hemmeren Praluent.Men denne episoden handler om mer enn kolesterol. Vi snakker om "deprescribing", spørsmålet om når og hvordan vi bør vurdere å redusere eller avslutte medisiner. Hvorfor blir vi stående på enkelte legemidler år etter år? Og hvordan skiller vi mellom tilbakefall, rebound og seponeringssymptomer?Vi spør også om lavere doser eller «mikrodosering» av medisiner noen ganger kan være fornuftig?Hva har Pål endret mening om siden han skrev Pillefellen?For kanskje handler god medisin ikke bare om hva vi behandler, men hvem vi behandler, hvor stor risikoen er og om behandlingen fortsatt er riktig fem eller ti år senere.En episode om å forstå tallene, stille bedre spørsmål og ta mer informerte valg om egen helse.Du finner Pål her: https://www.instagram.com/dr.branaes/Pillefellen: https://www.norli.no/boker/dokumentar-og-fakta/familie-og-helse/medisin-og-sykdom/pillefellenTakk til Mic Drop media for redigering

South Asians represent about a quarter of the world's population but account for over 60 percent of the world's heart disease. The highest rates of diabetes and metabolic syndrome. And yet most women in the community have no idea this could be coming for them.This week I spoke with Dr. Ambreen Mohamed, a cardiologist with a passion for improving cardiovascular health, particularly in South Asian communities. This is a conversation I have wanted to have for a long time, and it is personal. I lost my mother to a massive heart attack over a year ago, and like so many women in our community, her symptoms did not look like what we are taught to recognize.We talk about why women's heart attack symptoms are so often dismissed, why the research was built on men for decades, and why what we call atypical is actually just different. We get into the genetics that make South Asians uniquely vulnerable, including lipoprotein A, APOB, insulin resistance, visceral fat distribution, and why someone can look healthy on the outside and have significant cardiovascular risk on the inside. We talk about the cultural pressures that make South Asian women put everyone else first, and how chronic stress compounds an already elevated risk.We also cover what good prevention actually looks like. What to ask your doctor. What markers to check beyond a standard cholesterol panel. How pregnancy history, PMOS, preeclampsia, and early menopause all factor into cardiovascular risk assessment. And what is coming down the pipeline in cardiology that gives Dr. Mohamed genuine excitement.This is not a doom and gloom conversation. It is an empowering one. Because knowing your risk is the first step to doing something about it.South Asians make up about 25 percent of the world's population but account for over 60 percent of global heart disease, with the highest rates of diabetes and metabolic syndrome of any ethnicity.What you'll learn:Women's heart attack symptoms are often dismissed because they can present differently from the classic Hollywood version, including fatigue, jaw pain, back pain, nausea, and indigestion rather than crushing chest pain.Microvascular disease, disease of the smaller coronary arteries, is more common in women and diabetics and can be missed entirely on standard imaging.The skinny fat phenomenon is real: visceral fat, the fat that wraps around organs deep in the body, increases cardiovascular risk even in people who appear slim.Early menopause is an independent risk factor for high blood pressure, and the estrogen drop during perimenopause and menopause accelerates cardiovascular risk.Sleep apnea is one of the most underdiagnosed contributors to high blood pressure and should be screened for before jumping to medication.The foundation of prevention is not supplements or peptides: it is sleep, movement, diet, stress management, and knowing your numbers.Connect with Dr. Mohamed:WebsiteInstagramTikTok

Dr. Daniel Chong has spent years helping patients understand their true cardiovascular risk and take meaningful action to prevent heart attacks and strokes.In this episode, Rip and Dr. Chong dig into the confusing, often polarizing world of cholesterol and heart disease. Is LDL cholesterol really important? How low should it go? Is ApoB a better marker? What about calcium scores, lipoprotein(a), statins, saturated fat, and the growing noise around keto and carnivore diets?Dr. Chong offers a grounded, practical, and highly nuanced perspective. He explains why standard LDL cholesterol is only part of the picture, why ApoB and LDL particle number may provide a clearer view of risk, and why cardiovascular disease is never about one single factor. Instead, it is about the full internal environment: inflammation, endothelial function, blood flow, plaque stability, lifestyle, and diet.Rip and Dr. Chong also explore the limits of coronary artery calcium scores, the risks of relying on a “zero” score too early in life, and why soft plaque can still pose a serious threat even when calcified plaque is not detected.They also discuss saturated fat, heme iron, blood viscosity, hydration, testosterone therapy's potential effect on red blood cell count, and the fascinating protective layer inside our blood vessels known as the glycocalyx.This conversation is a reminder that cardiovascular prevention is about building a body that supports vitality from the inside out.You'll Learn:LDL cholesterol matters, but ApoB and LDL particle number may offer a more precise picture of cardiovascular risk.The longer LDL particles remain elevated, the greater the potential risk over time.Saturated fat can interfere with the body's ability to clear LDL particles from the bloodstream.Coronary artery calcium scores can be useful, but they do not detect soft, non-calcified plaque.A calcium score of zero does not always mean “clean arteries,” especially in younger people.Lipoprotein(a), or Lp(a), is an important marker to test at least once.Dr. Chong recommends looking at a broader cardiovascular panel, including lipids, ApoB, Lp(a), A1C, and hs-CRP.Heme iron from red meat is absorbed differently than non-heme iron from plants and may contribute to oxidative stress when elevated.Blood viscosity — or how “thick” your blood is — can influence endothelial function and plaque formation.Hydration, plant foods, and, in some cases, blood donation may help support healthier blood viscosity.The glycocalyx is a delicate, hair-like protective layer that supports endothelial function.A whole food, plant-based lifestyle remains one of the most powerful foundations for vascular health.Learn More About our 2026 Live PLANTSTRONG Events: https://plantstrongevents.com/ Let Us Help Your PLANTSTRONG JourneyLearn More About Our Corporate Wellness Program: https://liveplantstrong.com/corporate-wellness/ COMPLEMENT: Use code PLANTSTRONG for 30% off at https://lovecomplement.com/pages/plantstrong-special-offer Follow PLANTSTRONG and Rip Esselstynhttps://plantstrong.com/ https://www.facebook.com/GoPlantstrong https://www.instagram.com/goplantstrong/https://www.instagram.com/ripesselstyn/ Follow the PLANTSTRONG Podcast and Give the Show a 5-star RatingApple PodcastsSpotifyWatch on YouTubeEpisode Webpage

This episode is sponsored by Super Patch: https://bit.ly/misuperpatch Apply for Muscle Intelligence Coaching: https://muscleintelligence.com/apply You cleaned up your diet, cut the carbs, and your LDL went up. Your doctor circled it in red and reached for a statin. Dr. Anthony Jay spent five years doing heart disease research full time at Boston University Medical School — running autopsies, removing plaque from human arteries, publishing on oxidized LDL — and for most of that time he was a statin guy himself. His mentor took them and bragged about it. His textbooks put the men who invented them on a pedestal. Then he kept looking at what was actually inside the plaque, and at what the endpoint studies actually measured, and he changed his mind. He is the author of Estrogeneration and the new book Sugar Beat, and he runs a DNA consulting practice doing four consults a day. In this conversation he walks through the 28,000-person study that ranks insulin resistance more than five times higher than LDL as a risk for an early heart attack, explains what LDL is actually built to do in the body, and traces the fifty-year sequence in which the target moved from total cholesterol to LDL to particle number to particle size to ApoB — each time, he argues, right as a new drug became available. He lays out the mechanism he believes builds plaque in the first place, why your heart is designed to run on fat and what happens when you train it on sugar instead, and which markers he thinks are actually damaging the artery wall while nobody tests for them. Ben pushes back the whole way, with his own father and with a client whose LDL sits above 800. If your labs came back red and nobody explained what was actually measured, start here. KEY TAKEAWAYS The risk factor that outranked LDL by more than four to one in a 28,000-person study of real heart attacks, not blood markers What LDL is actually for, and why getting healthier can raise it by design The $40 scan he ran on himself that told him more than twenty years of cholesterol readings ever did Why he argues that lowering the number can leave you with more arterial calcification rather than less The genetic quirk he has never discussed publicly that makes olive oil and avocado a real problem for a surprising number of people CONNECT WITH DR. JAY Website – https://www.ajconsultingcompany.com DNA Analysis & Consults – https://www.ajconsultingcompany.com/dna.html YouTube – https://www.youtube.com/anthonyjaycast Instagram – https://www.instagram.com/anthonygjay Book – Sugar Beat: How Sugar, Not Cholesterol, Destroys Your Arteries Book – Estrogeneration: How Estrogenics Are Making You Fat, Sick, and Infertile

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Beyond Cholesterol: The Heart Health Markers That Matter [0:00:00] – Intro: Lettuce Contamination, Social Media & Local Business Impact Discussion of “fear of lettuce,” limited to 15 states (not Tennessee) How social media amplifies food scares Local “Build a Salad” restaurant going out of business and timing around lettuce scare [0:04:39] – Back-to-School Immune Support: Oral Probiotics & Iodine Nasal Spray Back-to-school season and rise in colds/sicknesses Oral probiotics for kids: oral microbiome, throat/sinus benefits Iodine nasal spray for parents and teachers: safety, use during school/gym, personal routines of Ed and Clint [0:08:04] – Supplement Industry & Big Pharma Buyouts Thorne bought by Procter & Gamble for $3.8B History of pharma mocking “granola/hippie” supplement culture, now buying brands Many acquired supplement brands failing under pharma ownership Difference between pharma customers and nutraceutical users (education, mindset) Nutrition World's preference for privately owned brands [0:14:00] – Life Lessons from Flying & Racing: Doing the Hard but Right Thing Ed's story: practicing engine-out landings, re-learning best glide speed Insight: sometimes you must “point the nose down” (do the counterintuitive hard thing) to survive Clint's race-car analogy: “you go where you look” – look down the track, not at the wall [0:18:01] – Food Label Claims: Olive Oil vs. Avocado Oil Products UC Davis testing of products “made with olive oil” – most passed authenticity tests Avocado-oil-labeled products often failing purity tests Takeaway: be more skeptical of “made with avocado oil” claims [0:18:31] – Prostate Cancer & “Treating the Terrain,” Not Just the Tumor Dr. Gio (prostate-focused naturopath): focus on the ground cancer grows in Historical context from Stephen Paget's work on tumor “soil and seed” Lifestyle “soil-building” recommendations: Resistance training, walking 150 minutes/week Waist circumference < half your height Sleep, stress reduction, nutraceuticals, nutrient-dense diet [0:21:58] – Multivitamins, Carotid Stenosis & Functional Benefits COSMOS study: Centrum multivitamin and patients with carotid narrowing Reported improvements in physical function (walking, climbing stairs) and symptoms (shortness of breath, fatigue) Ed's extrapolation: better-designed multis (True Grace, Life Extension, etc.) likely offer even more benefit [0:22:30] – Post-Infectious Cough: Honey + Instant Coffee vs. Prednisone Double-blind RCT comparing: Honey + instant coffee paste Prednisone Guaifenesin Honey + instant coffee dramatically outperformed prednisone in reducing persistent cough frequency Discussion of guaifenesin's role, safety, and its regulatory history in health food vs. pharmacy channels [0:30:12] – Prednisone, COVID & Anxiety: Personal Case Story Guest Dr. Curt Dearing shares: Followed COVID protocol including prednisone Developed severe, prolonged anxiety afterward (twice) Realization that prednisone triggered it Ed's summary of prednisone side effects: bone loss, cataracts, muscle wasting, weight gain; okay short term, risky long term [0:33:30] – Cardiovascular Disease, Statins, & New Drug Lifendra (PCSK9 Inhibitor Pill) CV disease framed as leading cause of death for most people Introduction of Lifendra (oral PCSK9 inhibitor, from Merck) as “breakthrough” LDL-lowering drug Comparison with Repatha (injectable PCSK9 inhibitor) Curt's key points: Lifendra lowers LDL but does not show reduction in cardiovascular death, heart attack, or stroke (per Merck's own wording so far) Repatha's trial data: minimal impact on non-fatal events; no reduction in CV deaths vs. placebo Very high cost (~$300+/month out of pocket; heavy insurance burden) Critique of LDL obsession in cardiology Need to ask: Why is the cardiovascular system inflamed and oxidized? Ed & Curt's “terrain” model: Bad inputs: ultra-processed food, toxins, poor sleep, chronic stress, lack of sun/movement Missing inputs: nutrient-dense foods, minerals, omega-3s, organ meats, sunlight, sleep, movement Example of amlodipine: lowers BP numbers but may increase arterial calcification (calcium channel blocker) For people unwilling to change lifestyle, drugs may offer marginal benefit—but not true health [0:41:05] – Curt's Book & Lab Markers That Matter More Than LDL-C Curt's book: “Beyond Cholesterol: The Ultimate Guide to Testing and Supplements for Heart Health” Emphasis on better markers: ApoB, LDL particle size/number, calcium score, etc. Book's Amazon performance briefly noted (new release bestseller in its category) [0:44:32] – Alternatives to Statins & PCSK9s: Bergamot & Lifestyle Curt's hierarchy: Lifestyle (diet, exercise, stress, sleep) Targeted supplements like bergamot (citrus extract): lowers harmful particles such as ApoB and supports “good” LDL function Only then consider pharmaceuticals, and very selectively Skepticism about recommending Lifendra at all; strong bias toward non-drug approaches [0:45:28] – Dr. Wolfson, Mold, and Cardiovascular Terrain Ed & Curt's respect for Dr. Jack Wolfson, “The Natural Heart Doctor” Mention of mold as a major, under-recognized driver of cardiovascular disease Reference to Dr. Wolfson's educational resources and upcoming podcast plans [0:48:04] – Key Takeaways on Lifendra & Heart Prevention Strategy Lifendra will not fix: seed oils, glyphosate exposure, mold, bad sleep, chronic stress Terrain-building priorities: Real food, omega-3s, sunlight Toxin reduction Mitochondrial support Foundational supplements Contrast: drugs = band-aids with side effects; nutraceuticals = “side benefits” when used correctly [0:52:28] – Wrap-Up Ed mentions Sprouts selling lab-grown meat and his strong opposition Update on Oura Ring: now tracking nighttime blood pressure and importance of BP dipping Listener story: young man post–heart surgery credits Nutrition World's education and support with changing his life Final thanks to Dr. Dearing and closing outro  The post Radio Show / Podcast – August 9, 2026 first appeared on Vital Health Radio.

Are prevention-focused labs and early screening actually catching disease before conventional medicine would, and is anyone doing enough of it? In this episode, Amber Warren, PA-C is joined by Michael Orloff, PA-C, a board-certified physician assistant who spent over a decade in emergency and trauma medicine before transitioning to functional medicine, to explore how cardiometabolic testing, early cancer screening, and lifestyle-first care can help patients stay out of the healthcare system altogether. Mike shares what he's seeing after his first year at FMI, coming from years of treating end-stage disease in the ER, and breaks down why he focuses on ApoB and lipoprotein(a) instead of relying on standard cholesterol panels alone, how zone-based training and lactate threshold testing let him build truly individualized cardiovascular prescriptions, and why insulin sensitivity sits at the center of long-term metabolic health. He also discusses why cancer screening guidelines often lag behind what he sees clinically, why radon exposure is an overlooked cancer risk in the Treasure Valley, and how simple, low-effort movement, like walking after meals, can meaningfully shift blood sugar and body composition. Whether you're trying to make sense of your cholesterol labs, curious about CGMs, thinking about weight loss, or just want a clearer picture of what proactive, data-driven prevention actually looks like, this episode offers practical insight from someone treating these issues every day. In this episode, you'll learn: How ApoB and lipoprotein(a) provide a more complete cardiovascular risk picture than LDL alone How zone two training, lactate threshold, and VO2 max testing personalize exercise prescriptions Why insulin sensitivity is central to cardiometabolic and metabolic health Practical levers for sustainable weight loss: dietary restriction, meal timing, and portion control How a continuous glucose monitor (CGM) reveals real-time, individualized blood sugar patterns Why early cancer screening, including colonoscopies, PSA, and CA-125, may need to start earlier than conventional guidelines suggest How environmental factors like radon exposure raise cancer risk in the Treasure Valley Why time, not motivation, is often the biggest barrier to aging well, and how to work around it Stay tuned for more conversations on functional medicine, cardiometabolic health, cancer prevention, longevity, and optimizing your health from the inside out!

Dr. Josh Axe spent two years exhausted before an advanced blood panel revealed the real problem: his vitamin B2 was almost undetectable, and his mitochondria were badly depleted. Once he corrected it, his energy went from a 6 out of 10 to a 10 out of 10. The fix wasn't a stimulant or a gadget, it was testing inside the cell (RBC markers, not just serum) instead of trusting "normal" bloodwork. If rest isn't fixing your fatigue, this is the episode that tells you where actually to look. As always, this is general wellness education and not medical advice, so run your own testing and dosing with your clinician. CLICK HERE TO BECOME GARY'S VIP!: ⁠https://bit.ly/4ai0Xwg⁠ Get Heal Your Cells by Dr. Josh Axe & Dr. Will Cole: https://bit.ly/4bN7AJh Listen to "The Dr. Josh Axe Show" on all your favorite platforms! YouTube: https://bit.ly/3TuvbYM   Spotify: https://bit.ly/4hHfE1J   Apple Podcasts: https://bit.ly/4yKYJ4p   Click here to connect with Dr. Josh Axe: https://bit.ly/3S7vzvX  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKpCYMBIOTIKA: "BRECKACYM30" FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TAB: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠ Podcasts: ⁠https://bit.ly/3RQftU0⁠ Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠ TikTok: ⁠https://bit.ly/4coJ8fo⁠X: ⁠https://bit.ly/3Opc8tf⁠ Facebook: ⁠https://bit.ly/464VA1H⁠ LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠ Website: ⁠https://bit.ly/4eLDbdU⁠ Merch: ⁠https://bit.ly/4aBpOM1⁠ Newsletter: ⁠https://bit.ly/47ejrws⁠ Ask Gary: ⁠https://bit.ly/3PEAJuG⁠ Timestamps 00:00 - Intro of Show 02:27 - Why 5,000-year-old medicine still works 04:40 - His mom's cancer diagnosis 09:00 - The first steps after a diagnosis 11:09 - The Greek test and hyperthermia 13:59 - Oxygen, sugar, and cell metabolism 16:25 - Choosing the right herb per person 18:27 - Waking at 3AM and inverted cortisol 19:04 - Ashwagandha as a cortisol adaptogen 20:32 - A sleep stack without melatonin 21:59 - Where to start with bloodwork 23:19 - Micronutrients and the vitamin B2 story 27:45 - Testing inside the cell, not the blood 29:37 - Lp(a), ApoB, and the right fats 39:18 - How stress and emotion block healing 43:55 - The "memory transplant" 46:38 - Heal Your Cells and the spinal infection 55:09 - Build muscle for mitochondria 59:47 - What it means to be an Ultimate Human Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.  Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Jim Otvos is a biophysical chemist who pioneered the use of nuclear magnetic resonance (NMR) spectroscopy to measure lipoprotein particles and developed the first FDA-cleared method for directly quantifying LDL particle number (LDL-P), a technology that has since expanded to provide broader insights into metabolic health, inflammation, insulin resistance, and mortality risk. In this episode, Jim recounts the unlikely story of transforming a flawed cancer test into a new way of measuring lipoproteins, explains what standard cholesterol tests can miss and why LDL-P and apoB can inform treatment decisions beyond LDL cholesterol alone, and dispels the misconception that large, "fluffy" LDL particles are benign. He also explores how NMR can reveal insulin resistance before blood sugar rises, GlycA as a marker of chronic low-grade inflammation, and the metabolic vulnerability index (MVX) as a potential measure of frailty, resilience, and mortality risk across the lifespan. Finally, Jim explains why NMR diagnostics remain underused despite the wealth of information they can extract from a single blood test. We discuss: How investigating a flawed 1986 cancer test led to the development of NMR (nuclear magnetic resonance) lipoprotein testing [3:30]; How standard lipid panels measure cholesterol and triglycerides, and why LDL cholesterol is estimated rather than directly measured [15:15]; How NMR spectroscopy measures lipoprotein particle size and concentration [20:30]; Why LDL particle number matters more than particle size, and why large, "fluffy" LDL is not benign [28:45]; Discordance between LDL cholesterol and LDL particle number: which measure better reflects cardiovascular risk? [36:30]; How metabolic syndrome and lipid-lowering treatment contribute to the discordance between LDL-C and LDL-P, and the value of particle number for managing risk [45:30]; Using the NMR-derived LP-IR score to detect insulin resistance and predict type 2 diabetes before glucose rises [51:15]; The development, commercialization, and uncertain future of the Vantera NMR Analyzer and NMR-based diagnostics [1:04:45]; The analytical efficiency of NMR testing and the data-driven development of the Metabolic Vulnerability Index (MVX) [1:16:00]; GlycA as an NMR-derived marker of systemic inflammation: its discovery, biological basis, and advantages over hs-CRP [1:25:45]; Developing the Metabolic Vulnerability Index (MVX): biomarkers of inflammation, malnutrition, muscle wasting, and mortality risk [1:34:00]; What MVX can tell us about longevity and mortality [1:44:15]; How MVX may reveal metabolic frailty and predict premature mortality decades in advance in young, healthy adults [1:50:30]; Potential applications of MVX for predicting treatment response, surgical resilience, and clinical trial outcomes, and the barriers to broader use [2:00:00]; ApoB versus LDL-P: their clinical similarities, the additional information provided by NMR, and barriers to broader adoption [2:07:30]; Interpreting the effects of the CETP inhibitor, obicetrapib, on LDL-P, apoB, and small HDL particles [2:13:00]; The future of NMR diagnostics and MVX: translating scientific potential into broader clinical use [2:20:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

We have another classic episode for you. Level up your primary prevention game. Learn when ApoB, Lp(a), and CAC actually change management, how to spot cardiometabolic risk before diabetes declares itself, and how to make smarter lipid decisions beyond the standard panel. We're joined by Dr. Greg Katz, cardiologist and prevention expert at NYU Langone Health.

Check out Marek Health at - https://ericrobertsfitness.com/erf_marekhealth.html?ref=podcast On today's episode I sit down with Rihanna, a health coach at Marek Health, to break down why your "normal" bloodwork might be the exact reason you still feel like garbage. We get into the markers most doctors never run — low ferritin quietly killing women's energy and weight loss, low DHEA leaving you wired but tired, and ApoB as a way better heart-risk read than the cholesterol number that looks "fine." If you're doing everything right and still feel off, this one explains why it's probably chemical and physiological, not you being lazy. Lose 10-20 lbs In 8 weeks - https://ericrobertsfitness.com/erf-1on1.html 90 Day Clubhouse Kickstart Program - https://ericrobertsfitness.com/clubhouse-page.html Free Calorie Calculator - https://ericrobertsfitness.com/free-calorie-calculator/ Buy One, Get One 50% Off, Legion Athletic Supplements Code "ERIC" HERE - https://legionathletics.rfrl.co/qj2dy Youtube Channel - https://www.youtube.com/@ericrobertsfitness Video Podcast: - https://www.youtube.com/@EricRobertsFitnessPodcast

Kan en blodprøve fortelle deg mer enn om du er frisk eller syk? Hva avslører tusenvis av blodprøver om den norske folkehelsen og hvilke biomarkører sier egentlig mest om biologisk alder, metabolsk helse og risikoen for sykdom?I ukens episode er lege Arne Sæter fra Amino tilbake som gjest. Siden sist har Amino vokst betydelig, og gjennom analyser av tusenvis av blodprøver og integrasjon med wearable-data har de fått et unikt innblikk i hvordan den moderne nordmann faktisk har det.Vi snakker blant annet om:Hva Amino har lært etter å ha analysert tusenvis av blodprøver.Hvilke biomarkører som betyr mest for energi, helse og longevity.Hvorfor insulin, ApoB og metabolsk helse er viktigere enn mange tror.De vanligste misforståelsene om kolesterol og hjertehelse.Hva som kjennetegner menneskene som lykkes best med å forbedre helsen sin.Hvordan søvn, stress, kosthold og trening setter spor i blodprøvene.Hvilke livsstilsendringer som gir størst effekt – med minst mulig innsats.Hvordan preventiv medisin kan endre måten vi tenker helse på de neste ti årene.Dette er en episode for deg som ønsker å forstå kroppen din bedre, ikke bare for å forebygge sykdom, men for å skape flere år med energi, styrke og god helse.Du finner Amino her: www.amino.noTakk for redigering: Torgeir Johansen ved Micdrop Media.

In this episode, I sit down with Dr. Jennifer Timmons to talk about what it really means to pursue wellness in a way that supports women's long-term health. We discuss why “strong is the new skinny,” how to think about body composition and aging, the importance of hormone testing, and practical movement habits that support both physical and mental health. If you've ever felt overwhelmed by health messaging or frustrated by “normal” lab results that don't match how you feel, this conversation will give you clarity and encouragement.- I talk with Dr. Timmons about her shift from conventional primary care to a more integrative, root-cause approach.- We discuss why body composition matters more than chasing thinness! Love!- Dr. Timmons explains why muscle mass is essential for aging well, bone health, and independence.- We unpack the difference between “normal” lab ranges and truly optimal health markers.- I ask about key wellness labs women should consider, including glucose, insulin, cholesterol, blood pressure, and ApoB.- We talk through hormone testing, including estrogen, progesterone, testosterone, thyroid, TPO antibodies, and FSH.- Dr. Timmons shares how symptoms matter even when lab results look normal.- We explore when hormone replacement therapy may be helpful and why lifestyle still matters first.- We break down realistic movement goals for women, including resistance training, Zone 2 cardio, and short bursts of high-intensity work.- We close with a conversation about mindset, self-care, intuition, and trusting your body.Connect with Dr. Jennifer TimmonsYou can apply to work with her virtually here: https://timmonswellnessmd.com/membership/Follow on Instagram: https://www.instagram.com/jennifertimmonsmd/Check out her informative website: https://timmonswellnessmd.com/New Resource: Breast Health Guide - dailywellnesscommunity.com/breast-health-guide→ Please take 1 minute to show your support of the show!  Apple Podcasts: Sign in and scroll to the bottom to review!https://podcasts.apple.com/us/podcast/daily-wellness-podcast/id1651051841Spotify: Leave a rating and follow the show! (Click on the 3 dots.) https://podcasters.spotify.com/pod/show/melisha-meredithYouTube: Subscribehttps://www.youtube.com/@DailyWellnessCommunity-podcastConnect with Melisha and the Daily Wellness Communityinstagram.com/dailywellnesscommunity/facebook.com/dailywellnesscommunityWebsite: dailywellnesscommunity.comEmail us at: info@dailywellnesscommunity.comSome products I mention may be affiliate links, which means I may receive a small commission if you decide to make a purchase through one of my links. Our family greatly appreciates your support, it helps us keep creating the free resources we make for you all!DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Olympic medalist turned health-tech founder Andrew Steele says the problem isn't you: it's that "normal" and "optimal" are two different things. In this episode, he breaks down how DNA, microbiome, and blood testing expose what's really behind your fatigue, brain fog, and bloating. And why one test, one time, will never tell you the full story. WHAT YOU'LL LEARN -       Why small, consistent daily habits move the needle on longevity more than big lifestyle overhauls -       How the ACTN3 gene explains why "average" training and health advice doesn't work for everyone -       What DNA methylation is, and why taking more B vitamins can backfire if you have an MTHFR variant -       Why "normal" bloodwork isn't the same as optimal health -       How the PhenoAge biological age test measures how fast you're really aging -       Why bloating and brain fog in midlife women are often linked to the estrobolome and gut bacteria -       Why microbiome and blood testing needs to be repeated over time, not done once -       The best way to prepare for accurate blood and microbiome test results -       The three biomarkers Andrew recommends testing first: methylation, gut-brain axis, and ApoB -       Why wearables alone can't give you the full picture of your health -       How Stride is integrating oral microbiome testing and wearable data -       Why data and dashboards alone don't change behavior without human coaching -       What's inside Stride's ST01 liposomal multivitamin and why it's formulated around methylation   TIMESTAMPS 00:00 Small Daily Habits, Genetics And The ACTN3 Gene Story 09:35 DNA Methylation, MTHFR And Why More B Vitamins Isn't Always The Fix 13:15 Why "Normal" Bloodwork Isn't Optimal, And The Biological Age Test 20:45 The Gut-Hormone Link In Midlife Women, And Why You Need To Retest 31:00 How To Get Accurate Results, And The 3 Biomarkers Worth Testing 36:45 The Future Of Health Tracking: Wearables, Oral Microbiome And Multiomics 40:30 Stride Membership Availability And Discount Code 43:45 Why Data Alone Won't Change Your Health Without Human Coaching 46:30 Inside Stride's ST01 Supplement, And Final Thoughts On Aging Well VALUABLE RESOURCES A BIG thank you to our sponsor who make the show possible: • Stride - Find out your biological age and how your daily habits are influencing it with DNA, bloodwork and microbiome testing with a Stride One membership  https://www.getstride.com/angela/ for 10% off  -       Follow Andrew on Instagram: https://www.instagram.com/andrewsteele/  ABOUT THE GUEST   Andrew Steele is a former Olympic medalist sprinter turned genomics entrepreneur. He co-founded DNAFit in 2013 and has spent over a decade building consumer genomics, microbiome, and blood-testing products. He is now the founder of Stride, a multi-omic health platform combining DNA, microbiome, and blood testing with in-house practitioner consultations to help people move from "normal" to optimal health. Want to go deeper? Start here:

Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff's personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy. What changed in the first two weeks: appetite, weight, and energy Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels Why alcohol and coffee stopped feeling rewarding The emerging link between GLP-1s, dopamine, and the brain's reward circuitry The trade-off between appetite control and a sense of vitality or spark This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines. This episode was made possible by: CocoaVia:. Use code COMMUNE2026 for 25% off at CocoaVia.com LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at ⁠⁠drinklmnt.com/commune⁠⁠. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 25% off your order at ⁠⁠vivobarefoot.com/commune⁠⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line.

Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained Artificial Sweeteners Linked To 62% Faster Cognitive Decline In Landmark Brazilian Study A study tracking more than 12,700 adults (average age 52) over eight years found that people consuming the most artificial and low-calorie sweeteners, roughly 191 mg a day, about what's in a single can of diet soda, showed cognitive decline 62% faster than the lowest-intake group, equivalent to 1.6 extra years of brain aging, with memory hit hardest. Six of the seven sweeteners tested, including aspartame, saccharin, and acesulfame K, were linked to faster decline; tagatose was the lone exception. Researchers point to gut-microbiome disruption, altered glucose and insulin signaling, and possible direct neuronal effects as plausible mechanisms. Host Dave Asprey breaks down why a dose this small was enough to move the curve, why tagatose deserves more scrutiny before being called "safe," and where diet products' short-term weight-loss marketing conveniently ignores the long-term cost to your brain. Source: https://www.inc.com/kevin-haynes/study-links-cognitive-decline-to-surprisingly-small-daily-amount-of-artificial-sweeteners/91376522 ~~ AI Analysis Of 1,722 Heart Scans Finds Muscle Quality Predicts Heart Attacks Independent Of Calcium Score Using data from the SCOT-HEART trial, a University of Edinburgh team ran an AI model against ten years of coronary CT angiogram scans, measuring skeletal muscle attenuation, a marker of myosteatosis, or fat infiltration into muscle tissue. Every 10-point increase in muscle density corresponded to a 31% lower heart attack risk and 39% lower all-cause mortality over the following decade, and critically, this held independent of coronary calcium score, the current gold-standard risk marker. The same low-density-muscle patients also showed higher lung attenuation, lower liver attenuation, and more torso fat volume, a pattern consistent with systemic insulin resistance rather than a muscle-specific issue. Host Dave Asprey unpacks why calcium score isn't capturing the full risk picture, why myosteatosis is really a readout of whole-body insulin sensitivity, and what he'd add to a routine workup on top of a calcium score. Source: https://www.theguardian.com/science/2026/jun/30/strong-chest-back-less-likely-heart-attack-analysis ~~ FDA Approves First Oral PCSK9 Inhibitor, Cutting LDL By Up To 60% Without Injections Merck's enlicitide (brand name Lipfendra) is now FDA-approved as the first once-daily oral PCSK9 inhibitor, lowering LDL cholesterol by up to 60% in a phase 3 trial of 2,912 patients, routinely bringing levels down to 50-60 mg/dL. It works by blocking PCSK9, a liver protein that tags LDL receptors for destruction, the same target as injectable drugs like Repatha and Praluent, which have shown roughly 20% reductions in heart attacks and strokes in high-risk patients. Lipfendra is priced at $315 for a 30-day supply, with no excess side effects reported versus placebo over six months, though long-term outcome data is still pending. Host Dave Asprey explains why crushing total LDL without checking ApoB, LDL particle number, or oxidized LDL is optimizing the wrong variable, and what he'd want on his labs before considering a drug like this. Sources: https://www.nytimes.com/2026/07/16/science/the-fda-approves-a-new-pill-to-slash-cholesterol-levels.html https://www.cnbc.com/2026/07/16/mercks-cholesterol-pill-gets-us-fda-approval.html ~~ Cyclospora Outbreak Tied To Taylor Farms Lettuce Spreads To 34 States, Prompts Nationwide Recall Federal investigators have linked a multistate cyclosporiasis outbreak to shredded iceberg lettuce from Taylor Farms de Mexico, with Michigan alone logging over 5,000 cases and 100+ hospitalizations, much of it traced to lettuce used at Taco Bell. Taylor Farms has recalled all iceberg lettuce sourced from central Mexico, and Walmart has pulled Marketside Iceberg Salad and Marketside Shredded Lettuce with specific date codes across 27 states. Cyclospora spreads through fecal contamination and causes weeks of watery, explosive diarrhea if untreated; washing doesn't reliably eliminate it, since the parasite requires heat above 158°F to inactivate. Host Dave Asprey explains why pre-washed, pre-cut bagged greens remain a recurring contamination risk no matter what the label claims, and connects the outbreak's gut damage to lingering gut-brain consequences long after symptoms resolve. Sources: https://www.usatoday.com/story/news/health/2026/07/18/taylor-farms-shredded-lettuce-sample-cyclospora/90969103007/ https://www.fda.gov/food/outbreaks-foodborne-illness/investigation-5-state-outbreak-cyclospora-illnesses-iceberg-lettuce-july-2026 ~~ New Research Links Excessive Gut-Brain Synchronization To Anxiety And Depression Emerging research on the enteric nervous system, which contains over 100 million neurons and sends more signals to the brain than it receives, finds that when the gut's electrical rhythm synchronizes too tightly with the brain's, that over-coupling correlates with higher rates of anxiety and depression. The gut communicates with the brain through the vagus nerve, hormones, and immune signaling, and dysbiosis or ENS dysfunction has separately been linked to mood disorders in both human and animal studies. Host Dave Asprey breaks down why the goal isn't maximum gut-brain connection but the right kind of connection, questions whether the coupling is driving the anxiety or the anxiety is driving the coupling, and makes the case for treating mood from the gut up instead of the brain down. Source: https://refractor.io/medical/enteric-nervous-system-brain-link-mental-health/ ~~ Rhonda Patrick Explains Why She Never Adds Bananas To Her Berry Smoothies Rhonda Patrick has been telling audiences she skips bananas in her berry smoothies because of polyphenol oxidase, an enzyme in bananas that degrades the polyphenols in blueberries linked to improved cognition and vascular health, based on in-vitro and food chemistry data. She now builds her smoothies on an avocado base instead, and notes that vitamin C from citrus can partially inhibit the enzyme for anyone unwilling to drop the banana. Host Dave Asprey weighs in on the gap between lab chemistry and clinical outcome data, why that gap doesn't make the mechanism any less real, and why this is a low-cost swap worth making even without a human trial behind it. Sources: https://www.reddit.com/r/Biohackers/comments/1v2jbib/dr_rhonda_patrick_i_dont_add_bananas_to_my/ https://www.foundmyfitness.com/episodes/polyphenol-oxidase-bananas-smoothies ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insight into a sweetener risk hiding in everyday diet products, a heart attack predictor buried inside routine CT scans, the tradeoffs of a new cholesterol drug, a produce recall worth paying attention to, the science behind gut-driven anxiety, and a smoothie mistake that's quietly undercutting your polyphenol intake. Host Dave Asprey connects clinical research, cohort data, and food chemistry into practical frameworks for protecting brain health, cardiovascular health, and gut-brain resilience. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: artificial sweeteners cognitive decline, aspartame brain aging, tagatose safety, diet soda memory loss, myosteatosis coronary CT, skeletal muscle attenuation heart attack, SCOT-HEART trial, coronary calcium score insulin resistance, enlicitide Lipfendra FDA approval, oral PCSK9 inhibitor, LDL particle number ApoB, cyclospora outbreak 2026, Taylor Farms lettuce recall, cyclosporiasis symptoms treatment, enteric nervous system anxiety, gut brain synchronization, vagus nerve mental health, Rhonda Patrick polyphenol oxidase, banana blueberry smoothie mistake, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:19 – Story 1: Artificial Sweeteners 02:05 – Story 2: Muscle Fat & Heart Risk 04:36 – Story 3: PCSK9 Cholesterol Pill 06:27 – Story 4: Cyclospora Lettuce Outbreak 07:56 – Story 5; Gut-Brain Axis & Anxiety 09:29 – Story 6: Banana vs. Blueberry 11:08 – Predictions for Next 5 Years See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Before menopause, our risk of heart disease is HALF what a man's is. Within a few years of our last period, it is EQUAL. By our seventies, it is HIGHER. So why is nobody screening us for it? This is the conversation midlife women have been waiting for. I sat down with Dr. Jayne Morgan, a research cardiologist and Vice President of Medical Affairs at Hello Heart, who is calling out menopause itself as the most missed opportunity in preventive cardiology. She is the creator of the Stairwell Chronicles, a science communicator who translates complex cardiology into kitchen-table language, and she has spent 25+ years researching what is actually happening to our hearts in midlife. This is our fourth cardiologist on the show. And she is different. She brings the research, the data, and a fierce honesty about why our healthcare system was built around the male body, and what we do about it now.   WE GO DEEP ON: • Why menopause is a CARDIOVASCULAR event, not a gynecologic footnote • The half / equal / greater stat that every midlife woman needs to memorize • The 37-minute delay women face in the ER for cardiac care, and the exact phrase that gets you seen • Why hot flashes, night sweats, palpitations, and brain fog are cardiovascular signals, not just inconveniences • What estrogen actually does for your heart and what happens when it drops, and the 10-year HRT window • Her take on statins, the online backlash, and what the research actually says about LDL • What to do if you tried a statin and felt terrible — • Why it is LDL AND insulin resistance AND inflammation — not one versus the other • The labs to demand: ApoB, Lp(a), hs-CRP, fasting insulin, CAC scan • Why women were excluded from cardiovascular clinical trials until 1993, and how that built the entire field on the wrong data • The exact advocacy phrase that gets your concern documented in your chart • Three things you can do this week that actually move the needle   This is not a doom episode. This is the conversation you bring to your doctor tomorrow.   TIMESTAMPS: • 00:00 — Why menopause is a cardiovascular event • 12:00 — The symptoms women miss and the 37-minute ER delay • 26:00 — Estrogen, HRT and the 10-year window • 42:00 — LDL, cholesterol and the statin debate • 54:00 — What to test, what to track, what to demand • 66:00 — Health equity and self-advocacy • 76:00 — Three things this week   Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube    Learn More About Dr. Jayne Morgan  Instagram ➜ http://www.instagram.com/drjaynemorgan   Website ➜   https://drjaynemorgan.com/ Hello Heart➜   https://www.helloheart.com/      Thank you to our show sponsors:  LEELA QUANTUM:  Get 10% off your first Leela Quantum order with the code NatalieJill at checkout  at https://midlifeconversations.com/leela TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL  BIOPTIMIZERS: Stop settling for one form of magnesium when your body needs all 7. This one has them all! Get yours at https://bioptimizers.com/nataliejill  and use code NATALIEJILL to save  Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com   Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit   For advertising inquiries: https://www.category3.ca/  Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen.  Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.

In this episode of The Performance Medicine Show, Dr. Rogers answers YOUR health and wellness questions!

Can you really reverse heart artery disease? In this episode, Dr. Robert Todd Hurst, MD, FACC, FASE, shares the remarkable story of a HealthspanMD member who thought he was doing everything right. Despite taking a statin, maintaining healthy blood pressure, staying active, and keeping his blood sugar under control, advanced imaging revealed he was still accumulating dangerous soft plaque in his coronary arteries. Dr. Hurst explains how plaque composition analysis works, why traditional cholesterol targets may not be enough for some people, and what happened when they implemented a more personalized strategy focused on achieving exceptional cardiovascular results. Today's guest is a HealthspanMD member with a strong family history of heart disease who was committed to protecting his heart health. After advanced CT angiography revealed significant soft plaque progression despite years of following conventional recommendations, he partnered with Dr. Robert Todd Hurst, MD, FACC, FASE, and the HealthspanMD team to take a more proactive, personalized approach. One year later, his results demonstrated what may be possible when root causes are identified and risk factors are optimized. Key Timestamps 00:03 – The patient's frustration despite doing everything "right." 00:45 – Understanding CT angiography and plaque composition analysis 01:32 – The concerning findings revealed by advanced imaging 02:15 – Why LDL goals below traditional guidelines may matter 03:00 – The strategy used to aggressively lower ApoB and LDL cholesterol 03:25 – One year later: the repeat CT angiogram results 03:45 – Soft plaque volume cut by more than half 04:00 – Low attenuation plaque reduced to zero 04:25 – What Dr. Hurst is seeing in patients with repeat plaque analysis testing 05:00 – Why guideline cholesterol targets may not be enough for everyone 05:35 – The seven root causes of coronary artery disease 06:05 – Lowering the risk of heart attacks, strokes, and dementia 06:45 – Can soft plaque disappear completely over time? 07:15 – Why proactive, personalized healthcare produces better outcomes 08:00 – The HealthspanMD philosophy for preventing and reversing heart disease Topics Discussed Reversing coronary artery disease Soft plaque vs calcified plaque CT angiography with plaque composition analysis ApoB and LDL cholesterol targets Coronary artery disease prevention Personalized cardiovascular medicine Root causes of heart disease Plaque regression Heart attack prevention Healthspan-focused healthcare   This information is for educational purposes only and is not medical advice. Don't make any decisions about your medical treatment without first talking to your doctor.   *Connect* *with* *HealthspanMD* :

Dave Crosland and Scott McNally break down the real differences between Anadrol and Winstrol during a contest cut before answering rapid-fire questions on TRT, Tren, HGH, SHBG, estrogen management, Nandrolone for joint pain, cycle design, bloodwork, CGMs for bodybuilding, and much more. 0:00 Anadrol vs Winstrol (Preview) 0:25 Support Our Sponsors 5:00 Anadrol vs Winstrol in a Contest Cut 8:30 Steroid Cycles Around a Rotation Job 13:50 Can P5P Reduce Tren Side Effects? 15:25 What Causes High SHBG? 19:40 CGMs for Bodybuilding: Worth It? 23:30 DIM & Calcium-D-Glucarate for Estrogen 25:45 When TRT Changes Your Life 27:35 Is a 50-Pound Second Cycle Realistic? 32:30 Painful Pharma Testosterone Injections 33:30 Should You Bulk with Tren? 35:00 Kenalog, Allergies & Muscle Growth 37:10 Managing Low Estrogen on Cycle 38:00 Nandrolone for Joint Pain 40:29 ApoB vs HDL: Which Matters More? 43:15 HGH Raw Supply Update 48:00 Switching from NPP to Tren 49:30 Is TRT Microdosing Dying? 51:20 Keeping Testosterone High Off TRT 54:00 When to Kickstart a Cycle 59:25 Bloodwork Options in Canada 1:02:00 Uncle Dave's Wisdom UK Blood Work Get your Labs done by Dave in the UK : https://evalbloodanalysis.com/home/ Support the Podcast Patreon — Help keep the show growing. Even $5/month makes a difference. https://www.patreon.com/thinkbigbodybuilding Sponsors TRUE NUTRITION — Custom supplements for serious lifters Use code THINK to save https://www.truenutrition.com/THINK STROM SPORTS — Performance supplements trusted by athletes UK: https://tinyurl.com/ydmbfa54 US: https://stromsportsus.com Supplement Source Canada — Top brand supplements with fast shipping http://www.supplementsource.ca Merch Official THINK BIG Merch — Train, represent, support the brand https://think-big.printify.me/products

Dr. John Kim was 33 years old, a practicing functional pharmacist who thought he was living a healthy life, when he walked into the ER with chest pain and was told he was probably fine. He wasn't. An 85% blockage in his LAD, a stent, three days in cardiac ICU, and a month later — a positive test for Bartonella, sky-high aspergillus antibodies, mycoplasma pneumonia, Epstein-Barr, parasites, and severe mercury toxicity traced back to childhood. Two years to clear the Bartonella. Six months for the mold. And a complete reinvention of how he practices medicine. In this conversation with Freddie, Dr. Kim breaks down what functional medicine is getting dangerously wrong right now — the supplement stacking, the endless detox protocols, the practitioners who skip the nervous system entirely — and lays out what actually has to happen first. Heart coherence before supplements. Nervous system regulation before binders. EMDR before mold remediation. And a lipid panel that actually includes lipoprotein A and APO B instead of just chasing LDL numbers. The second half of this episode goes deep on biotoxins and cellular damage in a way you won't hear in most wellness spaces. Dr. Kim explains the cell danger response — why the mitochondria shifts from making energy to playing defense, and why so many people with MCAS, long COVID, Lyme, and autoimmune conditions are completely stuck in that state — and what it actually takes to get out. He breaks down how toxins like heavy metals, mold, and BPA bind directly to DNA in what's called a DNA adduct, why plasma therapies and standard detox protocols don't reach that level of damage, and what does — butyric acid, TUDCA, and a sequenced approach that rebuilds the cell membrane before asking the body to clear anything. He also covers the IGL epigenetic blood test from Germany, protein misfolding, and why the goal of any good practitioner should eventually be to never see their patient again. Find Dr. John Kim at drjohnkim.com and on Instagram at john.pharmd.   Episode Highlights - [00:00] – Dr. John Kim shares the heart attack that changed his life at just 33 years old. - [07:30] – Why clean cholesterol and normal labs didn't prevent a life-threatening cardiac event. - [08:36] – The heart markers beyond cholesterol that deserve more attention. - [10:36] – Heart coherence, gratitude, and how nervous system regulation supports cardiovascular health. - [15:07] – Understanding the Cell Danger Response and why chronic illness gets stuck. - [20:22] – A practical healing hierarchy for mold illness, MCAS, and chronic inflammatory conditions. - [24:59] – Why circadian rhythm may be the most overlooked free intervention in health. - [37:46] – The problem with treating lab results instead of treating the person. - [44:24] – Should people order their own functional lab testing? The benefits and limitations. - [53:57] – A real-world story showing how heart coherence transformed chronic anxiety in six weeks. - [55:59] – The truth about plasmapheresis, detox culture, and expensive biohacking trends. - [01:01:58] – Why lasting healing requires resilience—not lifelong detox protocols.  Connect with Dr. John Kim: Website: https://drjohnkim.com Instagram: https://www.instagram.com/john.pharmd My Circadian App: https://mycircadianapp.com Upgrade Your Health LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN MaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKEN StemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52 Code: beautifullybroken CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of Resiliency Radio, Dr. Jill Carnahan welcomes cardiologist and longevity expert Dr. Abid Husain for an eye-opening discussion on the future of cardiovascular medicine. After years in conventional cardiology, Dr. Husain recognized that treating heart disease after it develops is not enough. Today, he combines cardiology, functional medicine, regenerative therapies, hormone optimization, and peptide science to help patients prevent disease and optimize performance. Together, they explore the hidden drivers of cardiovascular disease, including inflammation, gut dysfunction, toxic burden, sleep disturbances, hormone imbalances, and metabolic health. This conversation offers a roadmap for anyone interested in preventing heart disease, improving longevity, and understanding how regenerative medicine is reshaping the future of cardiac care.

High cholesterol has been treated as the main cause of heart disease for decades. But over the years, I've changed my mind. Today, I believe cholesterol is only part of the story, and that inflammation, insulin resistance, and metabolic health are often the real drivers of cardiovascular disease. In this encore episode, I'm revisiting one of my most talked-about Office Hours conversations to share how my thinking has evolved and why understanding the root cause of heart disease can completely change the way you approach prevention. In today's episode, I discuss: Why cholesterol alone is a poor predictor of heart disease—and the biomarkers I believe matter even more, including ApoB, lipoprotein(a), inflammation, and insulin resistance The surprising role sugar, refined carbohydrates, and metabolic dysfunction play in driving cardiovascular disease Why two people with the same cholesterol can have dramatically different heart disease risk—and how a personalized approach changes the conversation The nutrition, lifestyle, and testing strategies I use to help reduce inflammation, improve metabolic health, and lower cardiovascular risk at its source Heart disease isn't simply a cholesterol problem—it's often a metabolic and inflammatory problem. When you understand what's really driving your risk, you can stop chasing a single number and start addressing the underlying biology that supports lifelong cardiovascular health. Track your metabolic and cardiovascular health biomarkers: functionhealth.com/mark for 160+ lab tests at just $365/year. Use code MARK2026 for $50 off. Have a question you'd love answered on Office Hours? Submit it here' (0:00) The cholesterol and heart disease paradox; introduction and overview of cholesterol, inflammation, and metabolic health (1:11) Sponsor: Function Health (1:41) Traditional views vs. new science on cholesterol, inflammation, and heart disease (4:52) Inflammation and sugar as key factors in heart disease (8:41) Advanced markers: ApoB, lipoprotein fractionation, and comprehensive testing (13:57) Causes of inflammation and holistic heart disease prevention (19:35) Metabolic health risks, new technologies, and personalized interventions (22:35) Diet, exercise, lifestyle, and supplements for heart and metabolic health (25:03) Understanding heart disease beyond cholesterol (25:37) Sponsor: Brain Shaping Academy (26:33) Community engagement, sharing, and final thoughts (28:07) Sponsor acknowledgments and closing remarks

The newest AHA and ACC guidelines for treating dyslipidemia are here — and according to Dr. Kim Williams, they mark a powerful shift toward prevention, earlier testing, and whole-food, plant-based nutrition as the foundation of cardiovascular care.Rip welcomes back Dr. Kim Williams, past president of the American College of Cardiology, for a practical and deeply encouraging breakdown of what these updated cholesterol guidelines mean for everyday people.Dr. Williams explains why cardiovascular risk is no longer just about one cholesterol number. Instead, clinicians are being encouraged to look at the whole picture: LDL cholesterol, ApoB, Lp(a), inflammation, blood pressure, blood sugar, kidney function, family history, lifestyle, and coronary artery calcium when appropriate.The most exciting part for the PlantStrong community? Lifestyle optimization is now treated as the clinical foundation — and Dr. Williams is clear about what that means: a whole-food, plant-based diet built around beans, grains, nuts, seeds, fruits, vegetables, and mushrooms, along with exercise, sleep, mindfulness, strong social connections, and avoidance of tobacco, alcohol, and other harmful substances.This conversation also tackles statins, PCSK9 inhibitors, Lp(a), coronary calcium scoring, and the new philosophy of treating risk lower, earlier, and longer — always with food first, and medication when needed.Key TakeawaysThe new cholesterol guidelines emphasize lifestyle first, not lifestyle as an afterthought.Dr. Williams says a whole-food, plant-based diet should be built around beans, grains, nuts, seeds, fruits, vegetables, and mushrooms.LDL cholesterol is still important, but it is no longer the only number that matters.ApoB may give a clearer picture of risk in some people, especially those with diabetes, high triglycerides, or central obesity.Lp(a) is largely genetic and should be measured at least once in adulthood; the 2026 guideline includes updated recommendations for elevated Lp(a).Coronary artery calcium scoring can help personalize risk and guide LDL targets.Dr. Williams emphasizes that the goal is not “plants versus statins.” It is whole plant foods first, medications when needed.The overall prevention philosophy is: lower, earlier, longer.Watch the Episode on YouTube: https://youtu.be/6cD8tGpsAggLearn More About our 2026 Live PLANTSTRONG Events: https://plantstrongevents.com/ Let Us Help Your PLANTSTRONG JourneyLearn More About Our Corporate Wellness Program: https://liveplantstrong.com/corporate-wellness/ COMPLEMENT: Use code PLANTSTRONG for 30% off at https://lovecomplement.com/pages/plantstrong-special-offer Follow PLANTSTRONG and Rip Esselstynhttps://plantstrong.com/ https://www.facebook.com/GoPlantstrong https://www.instagram.com/goplantstrong/https://www.instagram.com/ripesselstyn/ Follow the PLANTSTRONG Podcast and Give the Show a 5-star RatingApple PodcastsSpotify

Are you worried about your cholesterol levels on your labs continuing to climb?     While conventional medicine bloodwork typically focuses on total cholesterol, LDL, and HDL, these markers don't always provide a complete picture of cardiovascular risk.     The good news is there's a more accurate marker called ApoB that can offer deeper insight. On today's show, I want to break down what ApoB is, why it matters more than traditional cholesterol markers, and the 7 most effective ways you can naturally lower it.     Tune into today's Cabral Concept 3786 to learn how to lower your ApoB naturally and support long-term heart health through simple, foundational lifestyle changes.     Enjoy the show, and let me know your thoughts!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3786 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Free course: Improve your metabolic healthGet our free email course on how glucose, nutrition, exercise, sleep, and measurement can help you build habits that support better energy and long-term health: ⁠⁠⁠https://levels.link/wnl⁠High cholesterol. Elevated ApoB. A positive CAC score. Now what?Most people quickly find themselves trapped between two extremes: simplistic advice to “cut saturated fat” and online influencers insisting cholesterol doesn't matter at all.In this episode of A Whole New Level, Mike Haney sits down with clinical research scientist Dr. Kevin Maki to cut through the confusion.Drawing on more than 35 years of cardiovascular research, Maki explains why heart disease risk is about much more than LDL cholesterol alone. He breaks down the roles of inflammation, blood sugar, family history, kidney function, and lipoproteins, while also making a clear case for something many people resist: LDL and ApoB still matter. A lot.The evidence increasingly suggests that when it comes to atherosclerosis, lower for longer is better. That has important implications for diet, statins, and how early we should intervene.Mike and Dr. Maki also tackle saturated fat, seed oils, red meat, industry-funded research, and how to separate evidence from online nutrition debates.

Most of us have had that moment where we get our bloodwork back and shake our heads. We're still our active, health‑minded selves and out of nowhere—rising LDL, ApoB, A1C, and maybe blood pressure and Lp(a), too. This week, preventive cardiology dietitian Michelle Routhenstein joins us to unpack the cardiometabolic chaos and what's really driving it. She explains estrogen's protective role in lipids and blood pressure, why standard risk calculators and even calcium scores can miss women's disease, and which advanced labs are worth asking for. We also dig into how under‑fueling and low‑carb diets can worsen cardiometabolic health and plaque; why complex carbs, fiber, fermented foods, and gut health matter so much; and how to approach protein, red meat, electrolytes, nitric oxide, and statins in a personalized, empowering way—remembering that 80–90% of heart disease remains preventable when women get the right information and advocate for themselves.Michelle Routhenstein, MS, RD, CDCES, CDN is a preventive cardiology dietitian and founder of Entirely Nourished, a virtual practice focused on personalized, science-based nutrition for heart health. With over 14 years of experience, she helps people improve cardiometabolic risk and manage conditions like atherosclerosis, heart failure, and atrial fibrillation using a whole-person approach. She holds Bachelor's and Master's degrees in Clinical Nutrition from New York University, serves on the Forbes Health Advisory Board and the Medical Advisory Committee for the National Menopause Foundation, and is the author of The Truly Easy Heart-Healthy Cookbook and Simple Meal Solutions for High Blood Pressure. Her work has been featured in outlets including Forbes Health, Fox News, Prevention, Women's Health, and Good Housekeeping, and she works with clients virtually from New York via www.entirelynourished.comJoin us at Feisty Fest September 18-20, 2026: https://feisty.co/events/feisty-fest/Sign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Learn More about our 2026 Feisty Events, including Bike Camps and Cycling Trips: https://feisty.co/events/Follow Us on Instagram:Feisty Menopause: @feistymenopauseHit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 20% off your order with code FEISTYBRAIN at https://www.previnex.com/ Wahoo: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdrCozy Earth: Use Code HITPLAY at https://cozyearth.com/ for up to 20% off

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube