Podcasts about apob

In this episode, preventive cardiologist Dr. Ann Marie Navar, a member of the committee that helped shape the American Heart Association's new recommendations for earlier cholesterol management, explains why many experts believe cardiovascular prevention should begin decades before most people ever experience symptoms. Dr. Navar explains why lowering LDL cholesterol earlier in life can have lasting benefits decades later, how ApoB and lipoprotein(a) are reshaping the way experts think about heart disease risk, and why some of the most popular fears surrounding statins aren't supported by the evidence. The conversation also explores the growing divide between evidence-based medicine and the wellness industry and the challenges of separating compelling biological theories from treatments that have actually been proven to improve health outcomes. She's a wealth of knowledge and a wonderful guest. Hope you enjoy.

Heart disease is not only a man's disease. It is the number one killer of women, responsible for ten times more deaths than breast cancer. And yet most women have never had a real conversation about their cardiovascular risk, because the medical system was not built to catch it in them.Dr. Martha Gulati is the Director of Preventive Cardiology and Associate Director of the Barbra Streisand Women's Heart Center at Cedars-Sinai, Director of the Davis Women's Heart Center at Houston Methodist, and author of Saving Women's Hearts. Her own quote has become one of the most cited lines in women's cardiology: "Heart disease is the number one killer of women, but lack of awareness is a close second."This conversation goes into how the female heart develops disease differently, why women's symptoms get dismissed even when they use the words chest pain, and the pregnancy complications, hormonal history, and inflammatory conditions that quietly raise cardiovascular risk for decades before anything shows up on a standard panel.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women's health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you'll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.⁠https://kayla-barnes-lentz.circle.so/female-longevity-community⁠If you're already paying attention to food, sleep, and overall health, cleaning products are another place where exposure adds up quickly. Branch Basics is a simple way to clean your home with fewer unnecessary ingredients and less clutter under the sink.⁠https://branchbasics.com/KAYLA15⁠ What we cover:How women's heart attack symptoms differ from men and why they still get dismissed in the ERWhy women wait longer, receive fewer tests, and are less likely to see a cardiologist when they arrive with chest painThe labs every woman should ask for, including LP(a), high-sensitivity CRP, and ApoB, with specific reference rangesWhy women get more cardiovascular benefit per minute of exercise than men, and what the exercise prescription actually looks likeMediterranean diet, hidden salt, sleep, and the lifestyle foundations that move the needleConnect with Kayla:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter:https://x.com/femalelongevityWebsite:https://www.kaylabarnes.com/Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227Follow Her Female Protocol: https://www.protocol.kaylabarnes.comConnect with Dr. Marth Gulati:Website: https://www.drmarthagulati.com/Instagram: https://www.instagram.com/drmarthagulatiLinkedIn: https://www.linkedin.com/in/martha-gulati-9b410496/Her Book (Saving Women's Hearts): https://www.drmarthagulati.com/general-2 #WomensHealth #HeartDisease #WomensHeartHealth #Cardiology #FemaleLongevity #HeartHealth #LongevityPodcast #PreventiveCardiology #HeartDiseaseInWomen #WomensCardiology #LongevityOptimization #KaylaBarnesLentz #HeartHealthForWomen #FemaleHealth #MarthаGulati

Você otimizou o LDL. Chegou na meta de ApoB. E o paciente volta meses depois com um novo evento. Neste episódio especial, com apoio da Novo Nordisk, Diandro Mota e William Batah recebem o Dr. Eduardo Lima, doutor em Cardiologia pela USP, professor colaborador e supervisor da Residência em Cardiologia da FMUSP/InCor e Head Nacional de Cardiologia da Rede Américas, para uma conversa que pode redefinir como você enxerga o risco residual. A tese é direta: a aterosclerose nunca foi só uma doença de colesterol. Ela é imunometabólica, e a inflamação subclínica pode ser o elo que faltava.O que você vai aprender:

Most of us have had that moment where we get our bloodwork back and shake our heads. We're still our active, health‑minded selves and out of nowhere—rising LDL, ApoB, A1C, and maybe blood pressure and Lp(a), too. This week, preventive cardiology dietitian Michelle Routhenstein joins us to unpack the cardiometabolic chaos and what's really driving it. She explains estrogen's protective role in lipids and blood pressure, why standard risk calculators and even calcium scores can miss women's disease, and which advanced labs are worth asking for. We also dig into how under‑fueling and low‑carb diets can worsen cardiometabolic health and plaque; why complex carbs, fiber, fermented foods, and gut health matter so much; and how to approach protein, red meat, electrolytes, nitric oxide, and statins in a personalized, empowering way—remembering that 80–90% of heart disease remains preventable when women get the right information and advocate for themselves.Michelle Routhenstein, MS, RD, CDCES, CDN is a preventive cardiology dietitian and founder of Entirely Nourished, a virtual practice focused on personalized, science-based nutrition for heart health. With over 14 years of experience, she helps people improve cardiometabolic risk and manage conditions like atherosclerosis, heart failure, and atrial fibrillation using a whole-person approach. She holds Bachelor's and Master's degrees in Clinical Nutrition from New York University, serves on the Forbes Health Advisory Board and the Medical Advisory Committee for the National Menopause Foundation, and is the author of The Truly Easy Heart-Healthy Cookbook and Simple Meal Solutions for High Blood Pressure. Her work has been featured in outlets including Forbes Health, Fox News, Prevention, Women's Health, and Good Housekeeping, and she works with clients virtually from New York via www.entirelynourished.comJoin us at Feisty Fest September 18-20, 2026: https://feisty.co/events/feisty-fest/Sign up for our FREE Feisty 40+ newsletter: https://feisty.co/feisty-40/Learn More about our 2026 Feisty Events, including Bike Camps and Cycling Trips: https://feisty.co/events/Follow Us on Instagram:Feisty Menopause: @feistymenopauseHit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099Support our Partners:Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Previnex: Get 20% off your order with code FEISTYBRAIN at https://www.previnex.com/ Wahoo: Use the code FEISTY2026 to get a free Headwind Smart Fan (value $300) with the purchase of a Wahoo KICKR RUN at https://shorturl.at/WVhdrCozy Earth: Use Code HITPLAY at https://cozyearth.com/ for up to 20% off

In Episode 499, Dr. Joel Kahn explores the growing importance of apolipoprotein B (ApoB) testing as a powerful tool for assessing cardiovascular risk. He reviews new research highlighting why ApoB may provide a more complete picture of atherosclerosis risk than traditional cholesterol measurements alone and explains how it relates to LDL-C and Lp(a). Dr. Kahn also discusses several noteworthy studies in preventive medicine and longevity, including research linking GLP-1 medications to lower cancer risk, the potential DNA-protective effects of melatonin, and new findings on stroke and clot prevention in patients with atrial fibrillation. Additional topics include the relationship between very low Lp(a) levels and diabetes risk, the benefits of organic produce for breast cancer prevention, Pilates training for blood pressure management, and the connection between processed meat consumption and gastrointestinal cancers. The episode concludes with a look at Endothelin-1 (ET-1), an important marker involved in vascular health and cardiovascular disease, along with a discussion of Vinia grape powder and its potential role in lowering ET-1 levels. Thanks to Igennus.com and their Triple Vitamin K Complex using the discount code DrKahn

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this episode of Everyday Epigenetics: Raw. Real. Relatable., Susan Robbins is joined by renowned expert lipidologist Dr. Tom Dayspring for Part 1 of a special two-part series on genetically driven lipid disorders. Together, they explore phytosterolemia (formerly known as sitosterolemia), a little-known but potentially serious genetic condition that affects how the body absorbs and processes plant sterols. While often overlooked in conventional healthcare, this disorder can contribute to elevated cholesterol markers, cardiovascular risk, xanthomas, kidney issues, and other health concerns when left undetected.Dr. Dayspring breaks down the complex science of cholesterol absorption, plant sterols, and the ABCG5 and ABCG8 genes in a way that is easy to understand. Susan shares what she has observed through years of genetic testing and coaching, including how frequently she is seeing these gene variants appear in practice and why many people are being missed by standard testing. This conversation highlights the importance of personalized medicine, advanced lipid testing, and understanding the unique ways genetics can influence long-term health outcomes.In this episode:What phytosterolemia is and why it is often missedThe difference between cholesterol and plant sterolsHow the ABCG5 and ABCG8 genes regulate sterol absorptionWhy some people absorb significantly more cholesterol than othersThe connection between plant sterol hyper-absorption and cardiovascular disease riskWhy standard cholesterol testing may miss important cluesThe role of sitosterol and campesterol testingHow phytosterols can impact cell membranes, kidneys, joints, blood cells, and other tissuesThe difference between heterozygous and homozygous loss-of-function gene variantsWhy many patients are told their cholesterol is "fine" when deeper issues may existThe importance of ApoB, non-HDL cholesterol, and advanced lipid testingWhy some cholesterol-lowering therapies work better than others depending on geneticsHow lifestyle, nutrition, and personalized interventions can support lipid healthWhen to consider working with a lipid specialistIf you have a family history of heart disease, unexplained cholesterol elevations, or have been told your numbers are "normal" despite ongoing concerns, or if use of statins hasn't helped yu, this episode offers valuable insight into a genetic factor that is rarely discussed but can have a significant impact on long-term health.Learn more about Dr. Tom Dayspring on the website shownotes!https://healthyawakening.co/2026/06/08/episode127/RESOURCES:Connect with Dr. Tom DayspringX: https://x.com/drlipidhttps://healthyawakening.co/2026/06/08/episode127/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

In this episode, we review key updates from the 2026 ACC-AHA Guidelines on the Management of Dyslipidemia. Key Concepts The PREVENT ASCVD equation is now recommended to calculate ASCVD risk, with thresholds at 3%, 5%, and 10%. The previous 7.5% threshold for statin treatment is now 5%. In addition to the 10-year ASCVD estimate, clinicians should consider the use of Lp(a), "risk enhancers", and coronary artery calcium (CAC) scans as a "tie breaker" with shared decision-making when the decision to treat is not clear. In addition to LDL goals of < 100, < 70, or < 55 (depending on risk), the new guidelines also suggest non-HDL-C and apoB goals once LDL cholesterol is at goal. Many patients will require non-statin therapies to achieve lipid goals. The recommended non-statin therapies include ezetimibe, PCSK9 mAb, PCSK9-interfering RNA, and bempedoic acid. References Writing Committee Members, Blumenthal RS, Morris PB, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(17):e1154-e1276. doi:10.1161/CIR.0000000000001423 Wiggins BS, Barac A, Benziger CP, et al. 2026 Dyslipidemia Guideline-at-a-Glance. J Am Coll Cardiol. 2026;87(19):2617-2623. doi:10.1016/j.jacc.2026.02.4872 Superko H, Garrett B. Small Dense LDL: Scientific Background, Clinical Relevance, and Recent Evidence Still a Risk Even with 'Normal' LDL-C Levels. Biomedicines. 2022;10(4):829. Published 2022 Apr 1. doi:10.3390/biomedicines10040829

“All good scientists are skeptics.” — Dr. Anthony Pearson  Key Links  The Skeptical Cardiologist on Substack is HERE   American Heart Association 2026 Guidelines is HERE   MESA CAC Database is HERE   In this episode, I'm joined by Dr. Anthony Pearson, the cardiologist behind The Skeptical Cardiologist newsletter on Substack, for a practical conversation about what women over 50 need to know now about heart health. We talk about the new cholesterol guidelines, why personalized risk assessment matters, and why tests like CAC, Lp(a), and ApoB can reveal much more than a standard lipid panel alone.  What You Will Learn:  Why heart disease is still the number one killer of women  The biggest blind spots women over 50 still have about heart risk  What changed in the new cholesterol guidelines  Why earlier detection and more personalized risk assessment matter  Why CAC, Lp(a), and ApoB are getting more attention  What those tests can reveal that a standard lipid panel may miss  Why statins still matter, despite all the noise around them  When non-statin options may make sense  The role of inflammation in cardiovascular disease  The lifestyle habits that still matter most for prevention  A few key takeaways from this conversation  You can feel healthy, exercise regularly, eat well, and still have hidden cardiovascular risk  A standard cholesterol panel does not always tell the full story  CAC, Lp(a), and ApoB can help create a more complete and individualized picture of risk  High Lp(a) is inherited and is important to know about, even before a specific drug is widely available  ApoB is a more precise marker of atherogenic particles and can add valuable information to routine testing  Statins remain an important, well-studied first-line tool for many people  Prevention works best when you start earlier, not after a cardiac event  Cardio exercise, strength training, and maintaining a healthy body composition all matter  Subscribe to AGE BETTER so you never miss an episode! 

"Insurance is there for when you're sick or when something goes incredibly wrong. It's not there for prevention."The traditional healthcare system is designed to treat you when you are sick. You go to a doctor for 15 minutes, get a basic blood panel, and if you are within the "reference range," you are told you are fine. The goal of this system is to get you from -1 back to 0.My guest this week is Prabhat Dhar, the Head of Growth for Superpower, a new platform that wants to take you from 0 to 100. Rather than treating late-stage diagnoses, Superpower provides comprehensive biomarker testing, looking at advanced metrics like ApoB, Fasting Insulin, and HSCRP, to detect diseases like cardiovascular risk or metabolic dysfunction up to a decade before they materialize as claims.In this episode, we discuss how Superpower translates complex biological data into a highly personalized, AI-driven action plan for your health (and your lifestyle). We also dive into why employers must stop relying on health insurance carriers to manage wellness, the power of decoupling proactive screening from the traditional system, and how to start bending the cost curve by focusing on root-cause analysis instead of late-stage symptom management.If you want to know what the future of employee health benefits looks like when it's built on individual biology instead of group claims data, this episode is for you.Thank you to our 2026 sponsors!ParetoHealth: ParetoHealth empowers midsize employers with a long-term solution to reduce volatility and lower overall health benefits costs. Visit https://www.paretohealth.com/fully-insured-vs-self-funding-with-paretohealth-spencer-podcast/?utm_source=youtube&utm_medium=referral&utm_campaign=SelfFundedwSpencer to learn more.Samaritan Fund: A program that connects those who need help to the support they need. We are proud to offer the Samaritan Fund Program. Visit SamaritanFundProgram.com to learn more.Vālenz Health: We're Vālenz Health, your partner in improving health literacy, reducing plan spend, and delivering high-value healthcare. Visit ValenzHealth.com to learn more.Imagine360: Imagine360 helps self-funded employers save on healthcare with smarter health plans. Cut expenses by 20-30% with custom solutions. Contact us today at Imagine360.com.Episode Chapters(00:00:00) Intro: Getting from 0 to 100 (Not Just -1 to 0) (00:01:21) Why the Primary Care "Quarterback" System is Broken (00:04:47) Decoupling Proactive Health from Health Insurance(00:07:42) The Origin Story of Superpower & Treating Crohn's Disease (00:12:06) Democratizing "Concierge" Functional Medicine (00:15:22) Why Traditional Blood Tests Miss the Real Signals (00:19:06) Translating Biomarkers into Personalized Action Plans (00:23:44) Overcoming "Point Solution Fatigue" with Biological Data (00:27:55) The Superpower Member Experience: How It Works (00:31:41) Integrating an AI Doctor Chat and Clinical Teams (00:33:42) How Superpower Augments Direct Primary Care (DPC) (00:41:22) The 5 Biomarkers You Need to Be Testing For (00:49:36) Moonshot: The Future of the "Health Super App" (00:54:51) Closing Thoughts: Moving from Success to SignificanceKey Links for Social:@SelfFunded on YouTube for video versions of the podcast and much more - https://www.youtube.com/@SelfFundedListen/watch on Spotify - https://open.spotify.com/show/1TjmrMrkIj0qSmlwAIevKA?si=068a389925474f02Listen on Apple Podcasts - https://podcasts.apple.com/us/podcast/self-funded-with-spencer/id1566182286Follow Spencer on LinkedIn - https://www.linkedin.com/in/spencer-smith-self-funded/Follow Spencer on Instagram - https://www.instagram.com/selffundedwithspencer/

"Insurance is there for when you're sick or when something goes incredibly wrong. It's not there for prevention."The traditional healthcare system is designed to treat you when you are sick. You go to a doctor for 15 minutes, get a basic blood panel, and if you are within the "reference range," you are told you are fine. The goal of this system is to get you from -1 back to 0.My guest this week is Prabhat Dhar, the Head of Growth for Superpower, a new platform that wants to take you from 0 to 100. Rather than treating late-stage diagnoses, Superpower provides comprehensive biomarker testing, looking at advanced metrics like ApoB, Fasting Insulin, and HSCRP, to detect diseases like cardiovascular risk or metabolic dysfunction up to a decade before they materialize as claims.In this episode, we discuss how Superpower translates complex biological data into a highly personalized, AI-driven action plan for your health (and your lifestyle). We also dive into why employers must stop relying on health insurance carriers to manage wellness, the power of decoupling proactive screening from the traditional system, and how to start bending the cost curve by focusing on root-cause analysis instead of late-stage symptom management.If you want to know what the future of employee health benefits looks like when it's built on individual biology instead of group claims data, this episode is for you.Thank you to our 2026 sponsors!ParetoHealth: ParetoHealth empowers midsize employers with a long-term solution to reduce volatility and lower overall health benefits costs. Visit https://www.paretohealth.com/fully-insured-vs-self-funding-with-paretohealth-spencer-podcast/?utm_source=youtube&utm_medium=referral&utm_campaign=SelfFundedwSpencer to learn more.Samaritan Fund: A program that connects those who need help to the support they need. We are proud to offer the Samaritan Fund Program. Visit SamaritanFundProgram.com to learn more.Vālenz Health: We're Vālenz Health, your partner in improving health literacy, reducing plan spend, and delivering high-value healthcare. Visit ValenzHealth.com to learn more.Imagine360: Imagine360 helps self-funded employers save on healthcare with smarter health plans. Cut expenses by 20-30% with custom solutions. Contact us today at Imagine360.com.Episode Chapters(00:00:00) Intro: Getting from 0 to 100 (Not Just -1 to 0) (00:01:21) Why the Primary Care "Quarterback" System is Broken (00:04:47) Decoupling Proactive Health from Health Insurance(00:07:42) The Origin Story of Superpower & Treating Crohn's Disease (00:12:06) Democratizing "Concierge" Functional Medicine (00:15:22) Why Traditional Blood Tests Miss the Real Signals (00:19:06) Translating Biomarkers into Personalized Action Plans (00:23:44) Overcoming "Point Solution Fatigue" with Biological Data (00:27:55) The Superpower Member Experience: How It Works (00:31:41) Integrating an AI Doctor Chat and Clinical Teams (00:33:42) How Superpower Augments Direct Primary Care (DPC) (00:41:22) The 5 Biomarkers You Need to Be Testing For (00:49:36) Moonshot: The Future of the "Health Super App" (00:54:51) Closing Thoughts: Moving from Success to SignificanceKey Links for Social:@SelfFunded on YouTube for video versions of the podcast and much more - https://www.youtube.com/@SelfFundedListen/watch on Spotify - https://open.spotify.com/show/1TjmrMrkIj0qSmlwAIevKA?si=068a389925474f02Listen on Apple Podcasts - https://podcasts.apple.com/us/podcast/self-funded-with-spencer/id1566182286Follow Spencer on LinkedIn - https://www.linkedin.com/in/spencer-smith-self-funded/Follow Spencer on Instagram - https://www.instagram.com/selffundedwithspencer/

Lower triglycerides, lower remnant cholesterol, lower ApoB. Zero change in coronary artery plaque. A new clinical trial is forcing a bigger conversation about how we treat cardiovascular disease.The drug was Olezarsen, an APOC3 inhibitor. The blood work looked impressive. The heart scans did not. So why would lowering well-established cardiovascular risk factors fail to move the needle on plaque? Dr. Bret Scher argues there's a critical difference between what we want to fix and how we go about fixing it. Lowering a number with a drug is not the same as addressing the underlying metabolic dysfunction that caused that number to be high in the first place.In this video, you'll learn:What the Olezarsen trial actually showed and why the results matterWhy elevated triglycerides often signal deeper metabolic dysfunction and insulin resistanceHow this same drug-first thinking plays out in type 2 diabetes, hypertension, and weight managementWhy narrowing our focus to "fix the number" can keep us from healing the whole systemHow metabolic medicine reframes the conversation around root causesThis isn't an argument against medication. Responsible drug use has an important place in patient care. But the best outcomes come when we ask why a number is abnormal in the first place and what combination of lifestyle changes and targeted treatments will actually address it.

The conversation delves into the rediscovery of ApoB as a significant cardiovascular marker and its suspiciously aligned timing with pharmaceutical profit motives. It explores the comparison between ApoB and LDLC, the rise of statins, the emergence of PCSK9 inhibitors, the controversy around ApoB, the context of metabolic dysfunction, and the pharmaceutical vs. metabolic approach to ApoB. It concludes with the distinction between treating a number and treating a disease.TakeawaysApoB has become a significant cardiovascular markerThe timing of ApoB's rediscovery is suspiciously aligned with pharmaceutical profit motivesChapters00:00 Treating a Number vs. Treating a Disease

For years, cholesterol numbers have been treated as one of the primary indicators of heart health, but are we focusing on the right markers? In this episode, I sit down with Dr. Terri DeNeui to discuss the bigger picture behind cardiovascular risk. We talk through the limitations of looking at LDL cholesterol in isolation, the importance of factors like inflammation, insulin resistance, ApoB, lipoprotein(a), calcium scores, and lifestyle habits, and why a more comprehensive assessment may be necessary before deciding on treatment options. We also discuss the role statins can play, who may benefit from them, and why individualized care matters when evaluating cardiovascular health.  We also explore the connection between hormones and metabolic health. Dr. DeNeui explains how changes in estrogen, progesterone, and testosterone can influence cholesterol, blood pressure, body composition, and overall wellbeing. Topics We Cover in This Episode:  Why cholesterol numbers rarely tell the whole story The cardiovascular markers many people have never heard of What calcium scores can and cannot tell you How insulin resistance often shows up long before diabetes The relationship between menopause, hormones, and changing cholesterol levels Why gut health keeps showing up in conversations about chronic disease The role estrogen plays in men's health and performance Questions worth asking when evaluating your long-term cardiovascular risk Whether you're trying to better understand your own lab work, navigate conversations about statins, or learn more about the connection between hormones and overall health, this episode offers a thoughtful discussion on some of today's most debated topics in preventive medicine. Join us as we explore the factors that may matter most when it comes to supporting long-term health and making informed decisions about your care. Resources & Links

In this conversation, Dr. Reza Ardalan sits down with Dr. Hugh Coyne, a London-based family medicine practitioner and the son of a pediatric dentist, who built Coyne Medical with his wife and clinical partner Dr. Lucy Coyne specifically to practice the kind of preventive medicine the NHS 10-minute appointment window does not allow. His training at Imperial College London and postgraduate work in obstetrics and gynecology, pediatric health, and sports medicine give him a panoramic view of the screening opportunities most dentists are sitting on without realizing it. Dr. Coyne walks through the short blood panel he would build into every dental practice: HbA1c for diabetes risk that directly changes wound healing and periodontal outcomes, highly sensitive CRP for the kind of cardiovascular inflammation a UK Biobank study of over 400,000 people linked to a 61% higher risk of cardiovascular death, vitamin D with the K2 pairing that keeps calcium out of arterial walls, renal function, and a full blood count. From there, Dr. Coyne and Dr. Ardalan move into the oral microbiome shift from pathogen elimination to ecosystem restoration, the role of P. gingivalis in rheumatoid arthritis through citrullinated protein antibodies, and the cardiometabolic markers most patients never get tested for, including apolipoprotein B and lipoprotein(a). The third act covers GLP-1 medications, the Gila monster origin story, the medieval cautionary tale of Sancho the Fat, and the dental-chair implications most patients will never volunteer on a health history form. In this Episode:  The short blood panel any dental practice can start with: HbA1c, highly sensitive CRP, vitamin D, renal function, and a full blood count Why vitamin D supplementation without vitamin K2 may direct calcium into the wrong tissues, including arterial walls How a UK Biobank study of more than 400,000 people linked elevated hs-CRP to a 61% higher risk of cardiovascular death in patients otherwise considered well What the 87% of patients open to in-chair screening tells you about how to introduce blood testing in your practice without losing trust The rule of halves for blood pressure, and why a 158 reading caught on a second visit can be profoundly consequential for a patient's long-term survival How the oral microbiome model has shifted from pathogen elimination to ecosystem restoration, and what that changes about prevention Why P. gingivalis turns up in rheumatoid arthritis tissue, and how oral pathogens correlate with colorectal, pancreatic, and esophageal cancers The bachelor-party analogy for apolipoprotein B and lipoprotein(a), and why every dentist should know their own Lp(a) number What every dental practice needs to know before sedating a patient on a GLP-1 medication   Dr. Hugh Coyne is a London-based GP and the co-founder, with his wife Dr. Lucy Coyne, of Coyne Medical, a family medicine practice focused on preventive care and the early detection of disease. Dr. Hugh Coyne trained at Imperial College London with postgraduate degrees in obstetrics and gynecology, pediatric health, and sports medicine, and is a featured speaker at the Wellness Dental Forum 2026. Find him on Instagram and TikTok at @drhughcoyne and the clinic at @coyne_medical. Want to go deeper on the oral–systemic connection? Dentistry & Whole-Body Health is a 3-part live CE series on reading the medical signals hiding in your patients' bloodwork — and knowing what to do with them. Session 1:  Hidden Signals · Saturday, November 7, 2026 The bloodwork your patients already have, read through a dentist's lens. HbA1c, hs-CRP, vitamin D, CBC — and when to monitor, pause, or refer. Session 2: Cardiovascular Clues · Saturday, November 21, 2026 The lipid markers most panels skip (ApoB, Lp(a)) and the oral–heart connection behind them. Yes — this is the bachelor-party one. Session 3: The New Weight Loss Era · Saturday, December 5, 2026 What GLP-1s are quietly doing to how your patients eat, metabolize, and heal — and the chairside adjustments that come with it. All 3-hour sessions run 8 AM PT / 11 AM ET / 4 PM UK, with 30-day recording access if you can't make it live. 9 AGD-PACE-approved CE credits across the series. Nothing here asks you to become a doctor — it gives you the medical layer that's already shaping your outcomes. Enrollment opens soon: $1,497 → Or try a single session — $625 More details coming soon!

Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) testedWhat a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person datasetWhy the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat aloneThe simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular riskBy the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.Thank you to our sponsors:OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYONBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Kevin Maki at:Midwest Biomedical Research: https://www.mbclinicalresearch.com/ LinkedIn: / kevin-c-maki-phd-497ba34 Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction00:31 - Dr. Kevin Maki and the National Lipid Association01:04 - New dietary guidelines and the LDL confusion02:04 - What raises and lowers LDL cholesterol03:51 - Cholesterol levels from birth through puberty05:11 - The lipid panel kids should get before age 1106:42 - Lp(a): the test only 2% of people get08:18 - ApoB and the three risky particle types11:35 - Do we have evidence for "lower is better"?14:09 - The FLASH-GLICK risk factor framework17:10 - The 10% saturated fat guideline explained19:36 - Many dietary patterns can be healthy24:50 - Beef vs. chicken: identical LDL results27:10 - The balance of fatty acids that matters29:24 - Olive oil vs. corn oil feeding study31:00 - Lower for longer: 40-year risk reduction34:15 - Genetic cholesterol disorders and risk40:33 - The omega-3 index and why it matters49:10 - Are seed oils really driving inflammation?53:11 - How seed oils are processed and refined1:07:48 - Inherited beliefs and outdated nutrition science1:08:54 - Butter vs. cheese and high-fat dairy surprises1:14:48 - Exercise effects on HDL and triglycerides1:21:20 - The ABCs of reducing cardiovascular riskIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

In this episode of Everyday Epigenetics: Raw. Real. Relatable., Susan Robbins sits down with physician, researcher, and science communicator Dr. Gil Carvalho for a powerful conversation about nutrition misinformation, influencer-driven fear, and what the science actually says about cholesterol, saturated fat, seed oils, oats, and popular diet trends. Dr. Gil Carvalho, founder of the Nutrition Made Simple YouTube channel, is known for breaking down complex health research into practical, understandable information without the fear tactics and sensationalism that dominate so much of the wellness world.Together, Susan and Dr. Gil unpack some of the biggest myths circulating online, including the idea that “higher cholesterol is always better,” that oats are harmful, and that seed oils are toxic. They also discuss why individualized health matters, how genetics influence risk factors like ApoB and Lp(a), and why lab work should guide decisions more than viral social media claims. This episode is a grounded, evidence-based conversation designed to help listeners think critically, ask better questions, and become stronger advocates for their own health.In this episode:Why high cholesterol should not automatically be dismissed as “healthy”The difference between cholesterol levels, ApoB, particle size, and Lp(a)How misinformation spreads through influencer cultureWhy oats are not the “worst breakfast you can eat”The truth about seed oils and inflammationHow genetics impact cardiovascular risk and dietary responsesWhy one-size-fits-all nutrition advice often backfiresThe importance of personalized nutrition and individualized lab workWhy fear-based wellness messaging can create more harm than goodHow social media oversimplifies complex health topicsThe role of lifestyle, stress, sleep, movement, and environment in long-term healthWhy learning to interpret science critically matters more than following trendsDr. Gil CarvalhoGil Carvalho is a Portuguese physician, research scientist, and science communicator known for his work in nutrition, longevity, and evidence-based health education.Born in Portugal, he earned his MD from the University of Lisbon and later obtained a PhD in Biology from the California Institute of Technology (Caltech), where he trained under pioneering geneticist Seymour Benzer.Carvalho's research spans genetics, molecular biology, nutrition, behavior, aging, and neuroscience, with contributions including the identification of genetic and nutritional mechanisms underlying longevity; his work has been cited over 4,130 times as of 2023 according to Google Scholar.He has collaborated with neuroscientist Antonio Damasio on neural signal transmission and the basis of interoception, and his publications appear in prestigious outlets such as Proceedings of the National Academy of Sciences and Nature Methods.In addition to his academic career at the University of Southern California, Carvalho is a prominent science communicator, founding the YouTube channel Nutrition Made Simple in 2018, which has amassed over a million monthly viewers by simplifying complex dietary science for lay audiences.He contributes to organizations including the Institute of Limbic Health, and his expert insights have been featured in media like Quanta Magazine and ScienceDaily.Carvalho has received awards such as the DeLill Nasser Award for Professional Development in Genetics and a Mathers Foundation grant, underscoring his impact in bridging clinical practice, rigorous research, and public health education.RESOURCES:Connect with Dr. Gil Carvalho:Youtube: http://www.youtube.com/@NutritionMadeSimpletwitter.com/NutritionMadeS3facebook.com/DrGilCarvalhotiktok.com/@nutrition.made.simpleinstagram.com/gilcarvalho.mdhttps://healthyawakening.co/2026/05/25/episode125/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

All links here: https://hunterwilliamshealth.com/links00:00 — Intro and why I'm doing these masterclasses02:42 — What we're covering and the regulatory timeline04:04 — The two users: weight loss vs longevity05:30 — What Retatrutide actually does (the three receptors)06:50 — Why the glucagon receptor makes Retatrutide different07:54 — Weight loss trial data (1mg to 12mg)10:50 — The longevity data: liver fat, ApoB, blood pressure13:14 — Who the lean biohacker user is13:50 — The titration playbook15:32 — Once weekly vs split dosing19:50 — Morning vs night injections21:02 — How far to push the dose (why 8mg is the ceiling)22:50 — How long to stay on and the regain problem25:44 — Longevity maintenance protocol26:34 — Lean user protocol27:24 — Protein and training are non-negotiable29:06 — Side effects and how to manage them30:20 — The heart rate question and why I use taurine32:00 — The weird skin sensitivity issue33:48 — Pairing Retatrutide with testosterone35:56 — Drug interactions (blood pressure, thyroid, insulin)37:02 — Metrics that matter38:42 — How to cycle off correctly39:54 — The most common mistakes40:42 — How to start, what to do if you plateau43:04 — Should you switch from Tirzepatide?45:28 — Combining Retatrutide with other peptides46:50 — The Ten Commandments of Retatrutide use47:50 — The bottom lineToday's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.Let me know what you think. I plan on doing many more of these on every peptide that matters.⚠️ For research and entertainment purposes only. ⚠️

What do your annual lab markers mean and are you getting a thorough assessment of your health? In this podcast, Ali Miller RD, walks through 47 essential biomarkers in the Naturally Nourished Comprehensive Wellness Panel. You will learn about the status of your white blood cells and red blood cells, markers of chronic infection, anemia, and even indicators of parasite activity. Ali will unpack in detail a comprehensive metabolic panel so you understand the fasting glucose and dawn phenomenon connection, markers of liver and kidney health, and how to support detoxification as well as further assess function with GGT and uric acid.   Beyond typical cholesterol markers and the ideal range, learn about the importance of ratios and other added markers such as homocysteine, ApoB, and CRP. Understand the blood sugar story connecting the dots of fasting glucose, fasting insulin, HgbA1C% and other ways to bring blood sugar levels into ideal range to support body fat burn. Learn about functional ranges of thyroid markers and food-as-medicine for iodine, selenium, and zinc.    Links: The Naturally Nourished Comprehensive Wellness panel is just $295 and includes a customized lab review with a functional nutritionist. Use LAB25 to save $25 off now!

Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:    Lauren: Hi Dr. Cabral, Thank you for all you do! I am grateful for all of the helpful information you share and your excellent supplements. I've been taking Advanced cell force for a couple of months. It's really the only new product I've been taking and after 6 years at the same Armour Thyroid dose of 60mg, my thyroid is overactive and my Naturopath has reduced my dose to 30mg. I'm getting levels retested Monday, so I'm curious to see what's going on. I was diagnosed with hashimotos in my early 20s but didn't need thryoid meds until 33 years old (now 43). Just seems interesting that after so long at the same dose, my thyroid is now functioning better. I'm grateful, just curious. Thanks again!      Denise: If toxins can be stored in fat cells and GLP 1's cause rapid weight loss, what happens to the toxins? Are they released from the body with the fat or are they let loose in the body to find a new place to hide? Does taking a GLP 1 help with stored toxins or cause more harm? And how do GLP 1's affect oxidative stress. Help or harm?      Tricia: Hi Dr. Cabral - Hope you are having a great day! Quick question on your sleep supplements. I'm 56 and thought I would start taking Melatonin. My sleep is not horrible but not as good as when I was younger. I noticed your Sleep Support supplement has Melatonin in it already. When would I use this supplement over Melatonin alone? I don't take Adrenal Soothe because I take Metavolve pm which I thought that might be double dosing of some     Mohamed: Hello Dr.Cabral, really enjoy your videos. The information you provide and your experience is invaluable. Thanks for all that you do for the entire community. My question is 2 part. Firstly regarding L-lysine and HSV/cold sores. I watched your older podcast on the topic.. but is there a recommended daily dose for Lysine? Second question is regarding Mouth-taping. How can I prep to clear my sinuses. A bit nervous. Would sinus support Equilife product help?      Larissa: Hello Dr Cabral, Thank you for all that you do and your wonderful advice! I have yet another question about cholesterol. I feel very conflicted about LDL cholesterol after reading a 2024 study regarding the lipid energy model. It suggested that high LDL levels in "Lean Mass Hyper-Responders" aka people on low carb diets may have different implications. I went low carb for 2 weeks and my LDL level increased from 140 to 187. My HDL levels remained high and triglycerides low but my Apo B levels increased as well. This is while being on omega 3, red yeast rice, and berberine. I want to be on Natokinase but was told I cannot while on hormones replacement therapy. Can you help me understand how LDL works? Can I use Natokinase while on HRT safely? Thanks so much!       Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3753 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

The episode explains that inflammation is a necessary survival mechanism, with acute inflammation supporting healing, while chronic inflammation drives chronic disease. It outlines major contributors to chronic inflammation including visceral fat (with fasting insulin as a proxy for insulin resistance), poor sleep and sleep apnea, ultra-processed foods, sedentary behavior, overtraining, chronic psychological stress, poor oral health, gut dysbiosis/barrier issues, smoking, alcohol, pollution, autoimmune disease, and chronic infection. The host reviews biomarkers to discuss with a physician such as high-sensitivity CRP, ESR, ferritin, WBC and neutrophil-to-lymphocyte ratio, fasting insulin, ApoB, omega-3 index/omega-6:omega-3 ratio, and homocysteine. Chronic inflammation is linked to cardiovascular disease, depression/anhedonia, brain fog, autoimmune disease risk, cancer mechanisms, skin aging, erectile dysfunction, and chronic pain. Treatment focuses on lifestyle (notably treating sleep apnea, sleep optimization, fat loss, exercise, oral health, omega-3 intake, sauna, stress regulation, circadian rhythm), selected supplements (vitamin D if deficient, curcumin, boswellia, ginger, garlic, olive oil polyphenols, sulforaphane, magnesium/glycine, taurine, NAC, quercetin, probiotics, creatine), and brief discussion of drugs including GLP-1 agonists, colchicine, NSAIDs, corticosteroids, and biologics.   Chronic inflammation https://www.ncbi.nlm.nih.gov/books/NBK493173/ C-reactive protein test https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/ ESR blood test https://medlineplus.gov/lab-tests/erythrocyte-sedimentation-rate-esr/ Ferritin blood test https://medlineplus.gov/lab-tests/ferritin-blood-test/ Homocysteine test https://medlineplus.gov/lab-tests/homocysteine-test/ ApoB test https://my.clevelandclinic.org/health/diagnostics/24992-apolipoprotein-b-test Insulin resistance https://www.ncbi.nlm.nih.gov/books/NBK507839/ Obstructive sleep apnea https://medlineplus.gov/ency/article/000811.htm CPAP therapy https://medlineplus.gov/ency/article/001916.htm Sleep hygiene https://www.cdc.gov/sleep/about_sleep/sleep_hygiene.html Physical activity guidelines https://www.cdc.gov/physical-activity-basics/guidelines/adults.html Ultra-processed foods https://pmc.ncbi.nlm.nih.gov/articles/PMC10831891/ Gum disease https://www.cdc.gov/oral-health/about/gum-periodontal-disease.html Gut microbiome https://www.nccih.nih.gov/health/gut-microbiome-what-you-need-to-know Fiber https://www.hsph.harvard.edu/nutritionsource/carbohydrates/fiber/ Autoimmune diseases https://medlineplus.gov/autoimmunediseases.html Inflammation and heart disease https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/inflammation-and-heart-disease Inflammation and depression https://pmc.ncbi.nlm.nih.gov/articles/PMC4566946/ Cancer and chronic inflammation https://www.cancer.gov/about-cancer/causes-prevention/risk/chronic-inflammation Omega-3 supplements https://www.nccih.nih.gov/health/omega3-supplements-what-you-need-to-know   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 Inflammation Basics 01:24 Acute Versus Chronic 03:29 Chronic Disease Link 03:52 Visceral Fat Driver 06:06 Sleep And Apnea 12:33 Food And Movement 16:02 Stress And Oral Health 18:17 Gut And Fiber 21:17 Toxins Autoimmune Infection 26:05 Inflammation Biomarkers 27:13 Inflammation Blood Markers 28:37 Ferritin Iron Balance 30:07 Metabolic Cardio Labs 32:08 Omega 3 Index Insights 34:07 Homocysteine Risks 34:58 Why Inflammation Matters 41:07 Lifestyle Fixes 46:24 Supplement Options 54:36 Medication Overview 57:36 Final Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Text Dr. Lenz any feedback or questions Three Blood Tests That Reveal Your True Heart Attack Risk: hsCRP, Lipoprotein(a), and ApoBDr. Michael Lenz argues the standard lipid panel can miss key drivers of atherosclerosis, explaining why some people with “normal” LDL still have heart attacks, and recommends three additional blood tests to better assess risk. High-sensitivity C-reactive protein (hsCRP) measures inflammation, with higher levels indicating increased risk and supported by the JUPITER trial showing benefit of statins in people with normal LDL but elevated hsCRP. Lipoprotein(a) is a largely genetic, “extra dangerous” LDL-related particle linked causally to heart attacks, strokes, and aortic valve disease; a one-time adult test is recommended, especially with early family history, and high levels warrant aggressive control of other risk factors while targeted therapies are in trials. ApoB counts atherogenic particles and may predict risk better than LDL, particularly with insulin resistance or diabetes.00:00 Hidden Heart Attack Risk01:53 Inflammation Fire Alarm03:06 hsCRP Risk Levels04:21 Lipoprotein A Genetics06:08 What to Do If High06:59 ApoB Particle Count08:27 ApoB Targets and Discordance09:23 Putting the Three Together10:17 Final Takeaways and Next Steps Support the showWhen I started this podcast and YouTube Channel—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That's why I created this space: to offer education, validation, and hope.  If you've been told fibromyalgia “isn't real” or that it's “all in your head,” know this—I see you. I believe you. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you'll find trusted, evidence-based insights here, drawn from my 29+ years as an MD.Please remember to talk with your doctor about your symptoms and care. This content doesn't replace per...

In this episode, I sit down with Dr. Leonard Kaufman — board certified urologist and men's health physician with 25 years of experience practicing in South Florida. Dr. Kaufman specializes in urology, hormonal health, sexual health, and preventative men's health care, and he brings a level of warmth, honesty, and clinical depth to this conversation that you won't find anywhere else. We cover a lot of ground — from why reactive health care is costing men years of quality life, to what erectile dysfunction is really telling you about your cardiovascular health, to the TRT conversation every man in his 30s and 40s needs to hear before he walks into one of those clinics and shuts off his own fertility without knowing it. But this is not just a clinical episode. Dr. Kaufman is 33 years married, dad of three, and one of the most genuinely human guests we've had on this show. We talk about the deli where he met his wife in medical school, what 33 years of a real marriage actually looks like, how to build a home where your kids feel safe enough to tell you anything, and what his wife's early loss of her mother taught them both about not wasting time. If you've been putting off that appointment — this episode is the nudge you need.   Timeline Summary [0:00] Introduction to the Dad Edge mission and the movement to raise leaders of families and communities [1:02] Reactivity vs. proactivity — why waiting until something is broken is costing men their lives [2:09] What Dr. Kauffman sees when men come in too late — prostate cancer, ED as a cardiovascular warning sign, and diabetes [4:14] How Viagra accidentally revolutionized men's health — and why men started showing up to doctors for the first time [7:27] Dr. Kaufman's background — board certified urologist, 25 years, fellowship in male infertility and andrology, MBA in Health Management [9:00] How he met his wife Cindy — a deli, a list of phone numbers, and a blind date that turned into 33 years [11:52] The non-negotiables of a long marriage — trust, transparency, communication, and shared values [13:49] Seen, heard, and safe — the three things a woman and your kids need to feel in your home [16:29] Vulnerability is not weakness in marriage — it's the foundation of real trust and real connection [19:49] What men most commonly come to Dr. Kaufman for — ED, low testosterone, and prostate health [32:00] ED is the canary in the coal mine — penile arteries are the first to show restricted blood flow, which means something else is coming [33:36] Diet talk — why extreme diets backfire and what a urologist actually recommends for men's health [38:45] The labs every man should be getting — ApoB, cholesterol panel, PSA, and why most men aren't being fully evaluated [42:07] Total testosterone vs. free testosterone — what the current guidelines actually say [43:15] Why getting a testosterone baseline in your 30s is one of the smartest proactive health moves you can make [44:17] Clomid as an off-label option — how it helps men produce their own testosterone instead of shutting the system down [45:06] The risks of walking into a TRT clinic without proper evaluation — fertility, blood thickness, PSA changes, and chasing a number that may not fix anything [51:10] Prolactin — what it is, why it matters, and what a high level could actually mean for your brain   Five Key Takeaways Proactive health care is not weakness — it's how you stay around for your kids and grandkids. The men who wait until something is broken are the ones who look back and say "I should have come in a year ago." Erectile dysfunction is not just a bedroom problem. It's a cardiovascular warning sign. The smallest arteries in your body are affected first — and that means something bigger is building downstream. Before you walk into a TRT clinic, get a full workup from a qualified urologist. Young men are unknowingly shutting off their sperm production and permanently altering their pituitary axis without realizing it. Stop chasing the number. A man at 500 who feels great doesn't need to be pushed to 1,000. How you feel matters more than the number on the lab result. Safety is the foundation of everything — in your marriage and with your kids. When the people you love feel safe to bring you anything, it changes everything.   Links & Resources First Form Microfactor: https://1stphorm.com/products/micro-factor/?a_aid=dadedge First Form Level 1 Protein Powder: https://1stphorm.com/products/level-1/?a_aid=dadedge Dr. Leonard Kaufman's office: (954) 228-0924 Find Dr. Kaufman via MVP Men's Health: Search "Dr. Leonard Kaufman" at mvpmensclinic.com   https://www.mdvip.com/doctors/leonardkaufmanmd Episode Link & Resources (Episode 1475): https://thedadedge.com/1475   Closing If there's one message from this episode that stands out, it's this: your health is not just about you — it's about being around for the people who need you most. Dr. Kaufman has spent 25 years watching men come in too late. Not because they didn't care, but because they were raised to believe that going to the doctor was weak. It's not weak. It's one of the most important acts of leadership a man can make. Get the labs. Know your numbers. And build the kind of home where the people you love feel safe enough to tell you the truth — because that's exactly what your doctor needs from you too. Go out and live legendary.

For decades, LDL cholesterol has been the go-to metric for assessing heart disease risk. But growing research suggests there's a better predictor: ApoB. But is it a predictor in itself, or is it a marker of something even more important?Apolipoprotein B (ApoB) is a protein found on all potentially harmful lipoprotein particles, like LDL, VLDL, and remnants. Because each particle carries one ApoB, it offers a direct count of the total number of atherogenic particles, something LDL cholesterol can't do.In this video, Dr. Bret Scher breaks down the key differences between LDL and ApoB, how metabolic health influences both, and why understanding the full picture is critical for preventing heart disease.

In this episode, Eric Bach gives a full one-year update after starting TRT (testosterone replacement therapy).He breaks down the physical, mental, hormonal, and performance-related changes he experienced over the last 12 months — including improvements in recovery, sleep, energy, mood, body composition, and cardiovascular biomarkers.This episode also dives into the biggest misconceptions around TRT, why many clinics oversimplify hormone optimization, and why balancing recovery, stress, thyroid function, sleep, and lifestyle matters just as much as testosterone itself.Eric also shares:his current training structurerecovery metricsdeadlift goalsconditioning approachnutrition simplification strategiesand how he stays lean while balancing business, family, and performance.Key Topics Covered:One year on TRT: what changedBody composition & muscle gainSleep, HRV & recovery improvementsDHEA, brain fog & hormonal balanceEstradiol, estrogen & aromatase inhibitorsTRT myths & misconceptionsCholesterol, APOB & cardiovascular healthCurrent strength & conditioning approachThe ADE Nutrition SystemWhy optimization is about alignment, not extremesWho This Episode Is For:Men considering TRTHigh performers optimizing hormones & recoveryMen 30–50 struggling with energy or recoveryAnyone interested in long-term performance & health optimizationPrimary Takeaway:TRT is not magic — but when combined with proper sleep, nutrition, recovery, training, and stress management, it can become a powerful tool for improving overall health and performance.Apply for coaching:https://apps.bachperformance.com/apply

If you're a woman navigating midlife and feel like your body is changing faster than you can keep up with, this episode is exactly what you need to hear. We sat down with Dr. Mary Pardee, naturopathic doctor, Menopause Society Certified Practitioner, and founder of ModrnMed, for one of the most honest, information-packed conversations we've had on The Body Pod.Dr. Pardee pulls back the curtain on why so many women are being dismissed or under-treated by their doctors., from being told they're too young for hormone therapy, handed a prescription with no real explanation, or simply rushed through a 15-minute appointment that barely scratches the surface. She breaks down exactly how estrogen and progesterone affect your gut, why IBS flares are so common during perimenopause, and what the gut-brain axis actually means for your everyday symptoms like bloating, cramping, constipation, and diarrhea.We also get into the real numbers behind menopause hormone therapy (MHT), including breast cancer risks, cardiovascular benefits, and how long you can safely stay on it — so you can walk into your next doctor's appointment informed and empowered. Dr. Pardee explains why she recommends DEXA scans for women well before the standard age of 65, what early bone density testing can catch, and why waiting too long could mean missing a critical window to protect your skeletal health.Beyond hormones and gut health, Dr. Pardee shares her approach to preventative and performance medicine. We talk advanced lipid panels and ApoB testing to VO2 max, strength testing, and cognitive assessments. She's not just treating symptoms; she's helping women build a body that feels just as strong and vital in their 80s and 90s as it does today.If you've been curious about concierge medicine, cognitive behavioral therapy for IBS, diaphragmatic breathing, or simply want a doctor who will actually sit down and talk with you instead of at you — this episode covers it all. Dr. Pardee also shares how to find the right specialist for your specific needs and what questions to ask to make sure you're getting the individualized care you deserve.

From reversing fatty liver in children to understanding LDL and HDL, Dr. Marbas uses case studies to show the power of plant-based diets. #LiverHealth #Cholesterol #HeartHealth #NutritionStories

In this episode, Lisa Oldson, MD shares a deeply personal story about her grandfather, who died of a heart attack at 47. His story is exactly why the brand new 2026 ACC/AHA Cholesterol Guidelines matter.In this episode you'll learn:The 3 LDL cholesterol targets everyone should knowWhy the new PREVENT risk calculator may change your doctor's conversation with you, and why you should ask for your 30-year risk, not just your 10-year riskWhat a coronary artery calcium (CAC) scan is, and why it's being called "the best tiebreaker" for people in the gray zoneTwo important blood tests, Lp(a) and ApoB, that your standard cholesterol panel is probably missingHow working on your weight may be protecting your heart at the same timeWhether you have a family history of heart disease, have been told your cholesterol is "a little high," or are simply invested in living a longer, healthier life, this episode is for you.Thanks for listening! If you'd like more support during your SMART weight loss & health focused journey, sign up for our FREE newsletter, or check out our program at: www.SmartWeightLossCoaching.com. We would love to help you reach your happy weight, and transform the way you talk to yourself about your body and the number on the scale. Negative thoughts about yourself don't have to take up so much brain space, and we'd be honored to help you reframe those thoughts. Also, we'd be grateful if you'd follow us and share our podcast with your friends & family. We're here to help you live longer, healthier, and lose weight the SMART way! This episode was produced by The Podcast Teacher: www.ThePodcastTeacher.com.The Smart Weight Loss Coaching Podcast is for informational purposes only and does not constitute medical advice. Always consult your physician or a qualified healthcare provider before starting, stopping, or changing any medication.

Today, we're diving into a topic that should be getting far more attention: Cardiovascular disease in women. Heart disease is one of the leading causes of death in women—yet it's often under-addressed, oversimplified, and misunderstood in clinical practice. Most women are told: “Eat better. Take this prescription.” But that approach misses something critical. Full citation list:    •    Hall, Kevin D., et al. “Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake.” Cell Metabolism, vol. 30, no. 1, 2019, pp. 67–77.e3. Supports the core causal point that ultra-processed foods drive higher intake and weight gain even under controlled feeding conditions; this is not a women-specific lipid paper, but it is the cleanest experimental anchor for why UPFs create a high-throughput metabolic environment.     •    El Khoudary, Samar R., et al. “Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association.” Circulation, vol. 142, no. 25, 2020, pp. e506–e532. Supports the midlife women's frame: across the menopause transition, LDL-C and ApoB rise, metabolic risk shifts, and cardiovascular prevention needs to become more deliberate during this window. This supports the “why I care about lipids in endocrine care” part of the episode.     •    Derby, Carol A., et al. “Lipid Changes During the Menopause Transition in Relation to Age and Weight: The Study of Women's Health Across the Nation.” American Journal of Epidemiology, vol. 169, no. 11, 2009, pp. 1352–61. Foundational SWAN paper establishing that the menopause transition itself — not just chronological aging — is associated with adverse lipid shifts in midlife women. This is the original observation that the timing argument rests on.     •    Wu, Bingjie, et al. “Trajectories of Blood Lipids Profile in Midlife Women: Does Menopause Matter?” Journal of the American Heart Association, vol. 12, no. 22, 2023, e030388. Supports the claim that LDL-C, total cholesterol, and ApoB follow distinct trajectory patterns through the menopause transition, with subgroups of women showing rising lipids in the years before the final menstrual period — useful for the timing argument that body and symptom changes can precede the obvious lab story.     •    Matthews, Karen A., et al. “Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation.” Journal of the American Heart Association, vol. 10, no. 18, 2021, e021362. Supports the point that ApoB and Apo A1 changes cluster around the final menstrual period and that adverse lipid shifts in the early postmenopausal years track with subclinical carotid disease later — connects menopausal timing to the longer cardiovascular arc rather than a one-time lab blip.     •    De Oliveira-Gomes, Diana, et al. “Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice.” Circulation, vol. 150, no. 1, 2024, pp. 62–79. Supports the practical ApoB explanation: ApoB reflects atherogenic particle burden and outperforms LDL-C for ASCVD risk prediction in many settings, but adoption lags because clear apoB targets and triggers are still lacking in mainstream guidelines. Good support for the public-service “what the hell is ApoB anyway?” section.     •    Williamson, Laura. “The Slowly Evolving Truth About Heart Disease and Women.” American Heart Association News, 9 Feb. 2024, heart.org/en/news/2024/02/09/the-slowly-evolving-truth-about-heart-disease-and-women. Supports the broader clinical framing that women remain underrecognized or undertreated in cardiovascular care and that women's heart disease still needs better public and clinical communication. This is more public-facing than mechanistic, but useful for your opening frame. Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.

Nessa live, respondi perguntas que foram enviadas pelo instagram:Conversamos sobreLLDL, Colesterol e ApoB;Calorias, Déficit Calórico e Restrição Calórica;Antinutrientes, Chás e Café;Carne, Câncer e Doenças Cardiovasculares;Sono e muito mais!No Clube de Leitura, exploramos juntos obras que desafiam o senso comum — livros que unem ciência, filosofia e ancestralidade — sempre com uma visão crítica e prática para transformar o conhecimento em ação.

If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Cynthia Thurlow, a nurse practitioner, CEO and founder of the Everyday Wellness Project, and a globally recognized expert in intermittent fasting and women's hormonal health. Her TEDx talk on intermittent fasting has surpassed 10 million views, and she brings over 20 years of functional medicine clinical experience to one of the most underserved conversations in longevity and human performance. Together, they tear apart the outdated medical narrative around perimenopause and menopause, exposing how a lack of knowledge, not biology, is destroying relationships, careers, and quality of life for millions of women. Dave and Cynthia dig into the gut microbiome's role in every symptom women experience in midlife, the mold toxin that is 10,000 times more potent than human estrogen and directly linked to hormonal chaos, and why biohacking your hormones as early as 35 could be the most important longevity move a woman makes. They also cover why statins are wrecking women's metabolism, how trauma accelerates ovarian aging and mitochondrial decline, the surprising connection between histamine reactions and hot flashes, and why GLP-1 micro-dosing alongside hormone replacement therapy is a game-changer for body composition and anti-aging. This episode is essential for listening for anyone serious about biohacking, sleep optimization, functional medicine, longevity, brain optimization, supplements, metabolism, human performance, and smarter not harder approaches to women's health. You'll Learn: Why perimenopause actually begins around age 35 and what to do about it before symptoms hit How a mold-derived xenoestrogen found in conventional beef disrupts hormones at 10,000 times the potency of human estrogen The gut microbiome changes that drive hot flashes, brain fog, weight gain, and mood disorders in perimenopause Why oral micronized progesterone beats topical for sleep optimization and hormonal stability How testosterone drives executive function, motivation, and brain optimization in women The lab tests every woman in perimenopause should run, including fasting insulin, ApoB, ferritin, and a full thyroid panel Why adverse childhood events and unresolved trauma age the ovaries and tank mitochondria How mold toxicity and Lyme disease create a hormonal perfect storm that no amount of supplements will fix The real reason 70 percent of divorces are initiated by women, and what hormones have to do with it Thank you to our sponsors! - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave - Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off. - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Cynthia Thurlow, The Menopause Gut, perimenopause, menopause, hormones, hormone replacement therapy, HRT, bioidentical hormones, progesterone, estrogen, testosterone, thyroid health, gut microbiome, women's health, functional medicine, biohacking, longevity, anti-aging, human performance, mitochondria, sleep optimization, metabolism, supplements, mold toxicity, zearalenone, xenoestrogen, hot flashes, brain fog, body composition, GLP-1, intermittent fasting, trauma, cortisol, adrenal health, leaky gut, histamine intolerance, mast cell activation, insulin resistance, fasting insulin, ApoB, ferritin, statins, ovarian aging, Dave Asprey, smarter not harder Resources: • Learn More From Cynthia And Get Her New Book The Menopause Gut at: https://www.cynthiathurlow.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 04:35 – Root Causes of Perimenopause 07:50 – When Perimenopause Starts 09:47 – Progesterone: When & How 12:16 – Testosterone for Women 14:14 – Thyroid & Energy 18:41 – FDA's HRT Policy Change 20:15 – Hormones & Divorce21:53 – GLP-1s & Body Composition 27:17 – Key Lab Tests 31:13 – AI & Budget Labs 39:44 – Gut Microbiome & Menopause 42:57 – Histamine, Mast Cells & Hot Flashes 47:55 – Toxic Mold & Xenoestrogens 50:31 – Dairy, Raw Milk & Leaky Gut 59:27 – Healing Trauma 1:03:00 – Book Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us Fan MailPerimenopause and menopause are about more than hot flashes and mood changes—they're also a critical time to assess long-term health risks. In this episode, Dr. Angela explains why cardiovascular disease risk rises during the menopause transition, often silently, and why women should know their blood pressure, cholesterol, ApoB, Lipoprotein(a), and overall metabolic health. She also shares practical prevention steps and why the most important intervention may sometimes be reducing heart attack or stroke risk—not just treating symptoms.Support the showFollow me on Instagram @angelalifestylemd and don't forget to SUBSCRIBE to my podcast & SHARE this episode.

The Cholesterol Code is a gripping new documentary from Jennifer Isenhart that challenges one of medicine's most entrenched beliefs. Following Dave Feldman's unexpected health journey, the film dives into the controversy around cholesterol, uncovering new research and raising a powerful question: what if we've misunderstood it all along? In this episode, Dr. Tro, Jennifer, and Dave talk about… (00:00) Intro (02:39) How the upcoming documentary film, The Cholesterol Code, came to be and how Jen crafted the film to be accessible to a wide audience (08:06) How Jen turns scientific data into an engaging film (15:33) The effort and passion Dave Feldman has poured into his research (17:49) Why YOU should watch this film (Jen's answer) (22:37) How Dave went from a curious software engineer to being one of the main forces driving research on cholesterol and metabolic disease (26:24) Coining the term 'lean mass hyper-responder' and founding the Citizen Science Foundation (31:19) Dave Feldman's critics and how to push back against dogmatic medical authoritarianism (44:29) The good and the bad of cholesterol (01:00:36) LDL, ApoB, and plaque progression (01:06:36) Why YOU should watch The Cholesterol Code (Dave's answer) (01:08:06) CAC, CCTA, ApoB, and LDL levels (01:14:08) Medications that reduce arterial plaque (01:16:19) Arterial plaque and the keto diet (01:26:23) The biggest myths that were dispelled in The Cholesterol Code film (01:29:27) Medical professionals who have come around to Dave and Jen's perspective on cholesterol (01:33:32) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Resources Mentioned in this Episode: THE CHOLESTEROL CODE (documentary film): https://cholesterolcodemovie.com/the-film/ Jennifer Isenhart: The Cholesterol Code (film): https://cholesterolcodemovie.com/the-film/ Fat Fiction (film): https://fatfiction.movie/our-story Dave Feldman: The Cholesterol Code (film): https://cholesterolcodemovie.com/the-film/ Cholesterol Code (website): https://cholesterolcode.com/ X: https://x.com/realDaveFeldman Citizen Science Foundation: https://citizensciencefoundation.org/ Own Your Labs: https://ownyourlabs.com/ Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

Nesta terça-feira, o nosso boletim destaca o papel central da evidência na transformação dos sistemas de saúde, começando pelas celebrações do Dia Mundial da Saúde 2026, que sob o tema "Juntos pela ciência", reforça a abordagem de "Uma Só Saúde" e a necessidade de decisões clínicas ancoradas em dados. Analisamos a nova diretriz da AHA/ACC sobre dislipidemias, que reposiciona metas agressivas de LDL — abaixo de 55 mg/dL para pacientes de alto risco — e incentiva o uso precoce de marcadores como o escore de cálcio e a ApoB. Por fim, exploramos no Radar a evolução da Telehealth para modelos de gestão contínua e intensiva em dados, exemplificada pelo crescimento biliário de plataformas que utilizam IA para monitorizar condições crónicas e tratamentos para a obesidade.Afya News. Informação médica confiável e atualizada no seu tempo.Fontes do episódio aqui:⁠https://portal.afya.com.br/podcasts/afya-news/07-04-2026

The Menopause Mastery Show | Understanding Women's Cardiac Health In Menopause | Episode 272 with John Osborne, MD, PhD, FACC, FNLA

Send us Fan MailDr. Angela breaks down the 2026 updated cholesterol guidelines in this essential episode for anyone concerned about heart health. Discover why these new guidelines represent a major shift toward precision prevention—moving beyond simple LDL numbers to give you a complete picture of your cardiovascular risk.What You'll Learn:Why everyone should get their Lipoprotein A (LP(a)) tested at least once—it reveals genetic risk independent of lifestyleThe importance of Apo B testing and the "Mini Coopers vs Escalades" analogy that hopefully makes it crystal clearWhen coronary calcium scoring can be the "tiebreaker test" for starting medicationHow the new PREVENT risk calculator improves on the outdated ASCVD calculator with expanded age ranges and social determinantsKey Takeaway: We're finally moving toward precision prevention—understanding what's behind your risk, not just treating numbers. This is the direction medicine needs to go.Perfect for patients who want to understand their heart health and healthcare providers looking to stay current with the latest evidence-based guidelines.Episode Chapters:0:24 - Introduction to New Cholesterol Guidelines0:46 - Lipoprotein A (LP(a)) Testing2:11 - Apolipoprotein B Testing4:14 - Coronary Calcium Scoring6:00 - New PREVENT Risk Calculator7:21 - Risk Categories & Personal Experience8:22 - Key Takeaways & SummarySupport the showFollow me on Instagram @angelalifestylemd and don't forget to SUBSCRIBE to my podcast & SHARE this episode.

Dr. Abid Hussain is a triple board-certified cardiologist in cardiology, internal medicine, and functional medicine. After years in the traditional hospital system in New Jersey, he walked away to focus on what actually prevents disease — and now practices at the Boulder Longevity Institute, combining conventional medicine with peptides, HRT, and longevity protocols.This is one of the most important conversations we've had on the podcast. If you're using hormones, peptides, or GLPs — or you're thinking about it — you need to hear what a real cardiologist has to say about all of it.In this episode, Hunter and Dr. Abid cover why cholesterol alone is a terrible predictor of heart disease, what APOB and particle size actually tell you, and why the AI-powered cardiac imaging most people have never heard of is the real state of the art. They break down the testosterone and heart disease myth — fully debunked — along with hematocrit, blood clots, and what's actually dangerous on TRT. They cover the Women's Health Initiative, why bioidentical and synthetic hormones are not the same thing, and what women of any age need to know about HRT.Then the conversation shifts to peptides — how BPC-157, TB-500, and Thymosin Alpha-1 benefit the cardiovascular system, what the SELECT trial proved about GLPs and heart health, why synthetic growth hormone and secretagogues are completely different, and how to think about cancer risk before starting GH protocols. They close with SS-31, Humanin, MOTS-C, and why the order you use mitochondrial peptides in actually matters — plus a deep dive into SGLT2 inhibitors, the most underrated longevity drug almost nobody in this space is talking about.Episode 3 of The Hunter Williams Podcast.https://hunterwilliamshealth.com/Podcast───────────────────────────CONNECT WITH DR. ABID HUSSAIN───────────────────────────

It's the future of medicine but how does it work, what are its origins and how can we benefit from it? In this episode I look at the way medicine can be tailored to our health.The work of Leroy Hood and P4 Medicine paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC4204402/The Human Genome Project: https://wellcome.org/insights/articles/human-genome-project-new-era-scientific-progressNHS personalised medicine page: https://www.england.nhs.uk/healthcare-science/personalisedmedicine/ApoB as a biomarker: https://www.nature.com/articles/s42003-024-05887-2Gut-skin links (systems biology): https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.01459/fullLeukaemia mutations: https://pmc.ncbi.nlm.nih.gov/articles/PMC6142505/AI for healthcare: https://www.imperial.ac.uk/stories/healthcare-ai/Methylation (MTHFR gene): https://www.healthline.com/health/mthfr-geneApoE genes and Alzheimer's risk: https://www.alzheimersresearchuk.org/news/apoe4-and-apoe3-gene-variants-linked-to-at-least-7-in-10-alzheimers-cases-study-suggests/Statins and their effect on inflammation: https://www.ahajournals.org/doi/10.1161/circresaha.116.308537My book THE HEALTH FIX: https://www.amazon.co.uk/Health-Fix-Dr-Ayan-Panja/dp/1914239326/ref=tmm_pap_swatch_0Save your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me. Hosted on Acast. See acast.com/privacy for more information.

Kann man Altern wirklich „cheaten“?In dieser Podcast-Folge spreche ich mit Iron Mike über Biohacking, Testosteron, Peptide und die Frage, wie weit man den menschlichen Körper wirklich optimieren kann.Iron Mike arbeitet seit Jahren mit Unternehmern, Politikern, Prominenten und High Performern. Viele von ihnen nutzen Methoden, die den meisten Menschen völlig unbekannt sind: Peptide, Hormone, Longevity-Protokolle und Biohacking-Stacks, die Energie, Leistungsfähigkeit und sogar das Altern beeinflussen sollen. Doch wie weit kann man wirklich  gehen?

Metabolic Health, Advanced Lipidology, and Preventing ASCVDLevel up your primary prevention game. Learn when ApoB, Lp(a), and CAC actually change management, how to spot cardiometabolic risk before diabetes declares itself, and how to make smarter lipid decisions beyond the standard panel. We're joined by Dr. Greg Katz, cardiologist and prevention expert at NYU Langone Health.Claim CME for this episode at curbsiders.vcuhealth.org!Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CMEShow Segments Intro Primary Prevention & Metabolic Syndrome (Case 1) Beyond the Standard Lipid Panel When to Order ApoB How Lp(a) Changes Management (Case 2) Using CAC/CCTA in the Gray Zone Recognizing Early Cardiometabolic Risk CGMs, Wearables, and Signal vs Noise (Case 3) How to Talk to Patients About Risk Take-Home Points CreditsWritten and produced by Paul Wurtz MD. Show notes, cover art, and infographic also created by Paul Wurtz MD. Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Sai S Achi MD, MBA, FACP Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Greg Katz MD DisclosuresDr. Katz reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures. Sponsor: DeleteMeGet 20% off your DeleteMe plan when you go to joindeleteme.com/CURB and use promocode CURB at checkout.Sponsor: Panacea Legal Visit Panacea.Legal  and use code CURB20 for 20% off contract review services.Sponsor: FIGSWe've teamed up with FIGS, and now Curbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX. Sponsor: Continuing Education CompanyFor Curbsiders listeners, there's a special offer: use promo code Curb30 for 30% off all online courses and webcasts. Visit CMEmeeting.org/curbsiders to learn more.  

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Audrey: Hi Dr. Cabral, What are your thoughts on retained reflexes? My almost 3 yr old girl has extreme outbursts every day that involves lots of screaming and yelling. I was told retained reflexes could be the problem. She is extremely smart and started talking at a very young age. I know she is too young for any heavy metal detoxes or parasite cleanses so I'm not sure how to help her. I also have a 4 yr old and a NB so having some peace in the home would be nice. Thanks      Cathy: Dear Dr Cabral, I'm so thankful for you! In the past 1.5yrs I've lost 30lbs and still losing more. Approx 160lb. 5'5" 64yo female. paleo diet. No gluten, dairy, grains or refined sugar. Very few deviations. I walk/hike 4-5x wk. Recently added strength. Hashimotos- currently NP Thyroid med 30mg.Taking med for 3 mo. Chol. is higher than ever 320. Triglycerides 143 HDL 57 LDL 236 ApoB 157 HDL-P total-29.3 Small LDL-P - 846 LDL size 21.5 CRP- 1.31 Iron runs high 163. I do not have hemochromatosis. TSH- 3.62 Reverse T3-12.5 Thyr perox- 65 Gut testing: Enterococcus spp- 4.60e8 Akkermansia muc -0 Bacteroidetes- 4.97e11 Firmicutes- 1.15e10 Bacciklus spp- 4.31e6 Enterococcus faecium- 4.35e5 Klebsiella spp- 1.35e5 Klebsiella pneumoniae- 3.45e5 Beyond thankful for any insight! God bless you!      Anonymous: Hi Dr. C — Big thanks to you and your amazing team for all you do. Question about purchasing pre-owned items: Are there any health concerns about buying used clothing items or bedding (sheets)? I always wash them before using them. Some people are grossed out about "used bedding," but it seems to be the same as going to a hotel: those aren't new sheets on hotel beds. Thanks.                                                               Sarah: Hello doc! I saw somebody say that red dots (cherry angiomas) on the body can be due to poor bile flow. Curious on your take on this? Cheers!      Basak: I had a quick question I wanted to ask. I divide my time between the Netherlands and Miami, and I maintain the same healthy habits in both locations—clean eating, daily exercise, minimal alcohol, and consistent sleep. I generally feel well and have no other complaints. However, I have noticed that whenever I return to Miami, I consistently experience lower abdominal bloating. I was wondering whether it is possible that environmental factors—such as differences in air quality, water, or other environmental exposures in the U.S.—could be contributing to this reaction. I would appreciate your perspective    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3698 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Talking about something you've heard me discuss before on here + reinforcing the importance of getting routine bloodwork done. Topics discussed:What routine bloodwork actually tells us (and what it doesn't)CRP and what inflammation markers can indicateLipid panel breakdown (HDL, LDL, triglycerides) + where ApoB fits in for cardiovascular riskVitamin D and its roles beyond bone healthVitamin B12: why it matters and key considerations for plant-based eatersTSH and a discussion around thyroid function and additional labs to checkHemoglobin A1c and long-term blood sugar controlComprehensive metabolic panel (CMP) + CBCTestosterone (total, free, SHBG) and why looking at all three gives better contextNutrition + lifestyle considerations for each+ so much more in-between. It's a longer episode but I know you'll be able to take a few things away from this one. Where to find me: IG: @lukesmithrdCheck out my website HEREFill out a 1:1 coaching application HERETIA for listening!!

Heart disease remains one of the leading causes of death, yet it rarely develops overnight. In this episode of the Pain and Performance Podcast, Dr. Derrick Hines discusses why cardiovascular disease builds gradually over time and how early testing and lifestyle interventions can significantly reduce risk. He explains the most important markers to monitor, why VO2 max is one of the strongest predictors of longevity, and how exercise, sauna therapy, nutrition, and targeted nutrients can support long-term heart health.In This Episode- Why heart disease develops slowly over years and why prevention should start early- The key cardiovascular tests that reveal risk, including ApoB, C-reactive protein, fasting insulin, and coronary calcium scores- Why VO2 max is one of the strongest predictors of longevity and cardiovascular health- How combining zone two training with high-intensity intervals can significantly improve heart function- The roles of sauna therapy, targeted nutrients, and anti-inflammatory nutrition in supporting long-term cardiovascular healthTikTok:https://www.tiktok.com/@drderrickInstagram:https://www.instagram.com/derrickbhines/Youtube:https://www.youtube.com/@DrDerrick

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter takes a deep dive into obicetrapib, an investigational drug that has captured his attention and renewed interest in an entire class of therapies known as CETP inhibitors. He explains what obicetrapib is and how it works, revisits the history of CETP inhibitors and why earlier versions of these drugs failed—sometimes dramatically—and breaks down the key clinical trials designed to evaluate their impact on cardiovascular risk. Peter examines how obicetrapib influences major lipid biomarkers, including LDL cholesterol and lipoprotein(a) [Lp(a)], and discusses emerging evidence from a study that explored the drug's effects on Alzheimer's-related blood biomarkers. He also highlights intriguing findings in individuals carrying the APOE4 allele and reflects on what these early results may mean for both cardiovascular disease prevention and potential implications for Alzheimer's risk, as well as how he is thinking about this therapy in the context of caring for his own patients. We discuss: Introducing obicetrapib: CETP inhibitor history, lipid biology, and early Alzheimer's biomarker signals in APOE4 carriers [2:15]; CETP biology explained: lipoproteins, reverse cholesterol transport, and how CETP inhibition alters HDL and LDL particles [5:15]; The early CETP inhibitor story: why raising HDL cholesterol alone failed to deliver cardiovascular protection [13:45]; The rise and fall of early CETP inhibitors: torcetrapib, dalcetrapib, evacetrapib, and anacetrapib [18:30]; Why obicetrapib may succeed where earlier CETP inhibitors failed [23:30]; The BROADWAY trial: obicetrapib's effects on LDL, ApoB, Lp(a), and residual cardiovascular risk [26:00]; Brain lipid metabolism and APOE4: how CETP inhibition may influence cholesterol transport in Alzheimer's disease [30:45]; Findings from the substudy of the BROADWAY trial which looked at changes in biomarkers of Alzheimer's disease [40:00]; Interpreting the BROADWAY Alzheimer's biomarker results: limitations, cautious optimism, and the need for a dedicated prevention trial [46:45]; Why Peter is optimistic about obicetrapib: cardiovascular benefits, Lp(a) reduction, and the path toward approval [50:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Angela and special guest Dr. Darshan Shah, look at the polarising world of cardiovascular health, specifically demystifying the role of LDL cholesterol.  They challenge the traditional one-size-fits-all approach to statins, arguing that heart health must be viewed through the lens of individual biology—where factors like inflammation, genetic risk, and lifestyle can make the same LDL level a non-issue for one person and a crisis for another WHAT YOU WILL LEARN LDL is Not Always the Enemy: A high LDL reading alone doesn't guarantee heart disease; its impact depends on individual context The Power of ApoB and Lp(a): Traditional cholesterol panels are often insufficient; more modern biomarkers like ApoB(a superior risk marker) and Lp(a) (a genetic factor) provide a much clearer picture of cardiovascular risk. AI in Diagnostics: The Clearly scan uses AI to analyse CT angiograms, allowing doctors to see the actual buildup of both calcified and soft plaque in the coronary arteries rather than just guessing based on blood work. Precision Over Dogma: Because cardiovascular health is an "N-of-1" situation, interventions like statins or PCSK9 inhibitors should be based on actual arterial health TIMESTAMPS: 01:21 The LDL Controversy: An explanation of why cholesterol remains a polarizing topic and why it must be treated as an individual biology issue. 02:37 The Tale of Two Patients: A comparison of a healthy gym-goer with high LDL/zero plaque versus a high-stress professional with lower LDL/significant plaque. 04:13 Modern Biomarkers: A breakdown of the specific tests to ask for, including ApoB, HS-CRP, and the Clearly cardiovascular scan. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

High cholesterol is one of the most widely discussed—and established—risk factors in medicine. But reams of research now show that while it is key to cardiovascular risk, it is not the whole story.In this episode of A Whole New Level, editorial director Mike Haney sits down with Dr. Ronald Krauss, one of the world's leading lipid researchers and a pioneer in understanding how different forms of LDL—and the physiological factors around them—affect cardiovascular risk.Dr. Krauss explains why the basic link between cholesterol and heart disease is well established among experts—but also why the standard cholesterol panel often misses the deeper metabolic story. Drawing on decades of research, he walks through how lipoproteins, particle size, triglycerides, and metabolic health interact to determine whether cholesterol actually becomes dangerous.Along the way, the conversation explores why cardiovascular disease remains the leading killer despite statins and decades of research—and how factors like obesity, insulin resistance, and inflammation reshape the lipid landscape in ways that traditional tests may not capture.The result is a clearer framework for understanding cardiovascular risk: not just how much cholesterol is in the blood, but how it's being transported, how long those particles circulate, and what metabolic conditions are driving them.Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠https://levels.link/wnl⁠⁠In this episode, we coverWhy the cholesterol–heart disease link isn't actually controversial among researchersCholesterol vs. lipoproteins: why the particles carrying cholesterol matter more than the number itselfSmall dense LDL: how triglyceride metabolism produces the most harmful particlesApoB and particle counts: why many researchers prefer measuring particles instead of cholesterol massLipoprotein(a): the genetically driven risk factor affecting up to a third of the populationMetabolic syndrome: the cluster of conditions that amplifies cardiovascular riskWhy carbohydrates and metabolic dysfunction can drive harmful lipid patternsThe saturated fat debate: why food context and metabolic health matter more than simple fat categories