Podcasts about apob

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Audrey: Hi Dr. Cabral, What are your thoughts on retained reflexes? My almost 3 yr old girl has extreme outbursts every day that involves lots of screaming and yelling. I was told retained reflexes could be the problem. She is extremely smart and started talking at a very young age. I know she is too young for any heavy metal detoxes or parasite cleanses so I'm not sure how to help her. I also have a 4 yr old and a NB so having some peace in the home would be nice. Thanks      Cathy: Dear Dr Cabral, I'm so thankful for you! In the past 1.5yrs I've lost 30lbs and still losing more. Approx 160lb. 5'5" 64yo female. paleo diet. No gluten, dairy, grains or refined sugar. Very few deviations. I walk/hike 4-5x wk. Recently added strength. Hashimotos- currently NP Thyroid med 30mg.Taking med for 3 mo. Chol. is higher than ever 320. Triglycerides 143 HDL 57 LDL 236 ApoB 157 HDL-P total-29.3 Small LDL-P - 846 LDL size 21.5 CRP- 1.31 Iron runs high 163. I do not have hemochromatosis. TSH- 3.62 Reverse T3-12.5 Thyr perox- 65 Gut testing: Enterococcus spp- 4.60e8 Akkermansia muc -0 Bacteroidetes- 4.97e11 Firmicutes- 1.15e10 Bacciklus spp- 4.31e6 Enterococcus faecium- 4.35e5 Klebsiella spp- 1.35e5 Klebsiella pneumoniae- 3.45e5 Beyond thankful for any insight! God bless you!      Anonymous: Hi Dr. C — Big thanks to you and your amazing team for all you do. Question about purchasing pre-owned items: Are there any health concerns about buying used clothing items or bedding (sheets)? I always wash them before using them. Some people are grossed out about "used bedding," but it seems to be the same as going to a hotel: those aren't new sheets on hotel beds. Thanks.                                                               Sarah: Hello doc! I saw somebody say that red dots (cherry angiomas) on the body can be due to poor bile flow. Curious on your take on this? Cheers!      Basak: I had a quick question I wanted to ask. I divide my time between the Netherlands and Miami, and I maintain the same healthy habits in both locations—clean eating, daily exercise, minimal alcohol, and consistent sleep. I generally feel well and have no other complaints. However, I have noticed that whenever I return to Miami, I consistently experience lower abdominal bloating. I was wondering whether it is possible that environmental factors—such as differences in air quality, water, or other environmental exposures in the U.S.—could be contributing to this reaction. I would appreciate your perspective    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3698 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode, Peter takes a deep dive into obicetrapib, an investigational drug that has captured his attention and renewed interest in an entire class of therapies known as CETP inhibitors. He explains what obicetrapib is and how it works, revisits the history of CETP inhibitors and why earlier versions of these drugs failed—sometimes dramatically—and breaks down the key clinical trials designed to evaluate their impact on cardiovascular risk. Peter examines how obicetrapib influences major lipid biomarkers, including LDL cholesterol and lipoprotein(a) [Lp(a)], and discusses emerging evidence from a study that explored the drug's effects on Alzheimer's-related blood biomarkers. He also highlights intriguing findings in individuals carrying the APOE4 allele and reflects on what these early results may mean for both cardiovascular disease prevention and potential implications for Alzheimer's risk, as well as how he is thinking about this therapy in the context of caring for his own patients. We discuss: Introducing obicetrapib: CETP inhibitor history, lipid biology, and early Alzheimer's biomarker signals in APOE4 carriers [2:15]; CETP biology explained: lipoproteins, reverse cholesterol transport, and how CETP inhibition alters HDL and LDL particles [5:15]; The early CETP inhibitor story: why raising HDL cholesterol alone failed to deliver cardiovascular protection [13:45]; The rise and fall of early CETP inhibitors: torcetrapib, dalcetrapib, evacetrapib, and anacetrapib [18:30]; Why obicetrapib may succeed where earlier CETP inhibitors failed [23:30]; The BROADWAY trial: obicetrapib's effects on LDL, ApoB, Lp(a), and residual cardiovascular risk [26:00]; Brain lipid metabolism and APOE4: how CETP inhibition may influence cholesterol transport in Alzheimer's disease [30:45]; Findings from the substudy of the BROADWAY trial which looked at changes in biomarkers of Alzheimer's disease [40:00]; Interpreting the BROADWAY Alzheimer's biomarker results: limitations, cautious optimism, and the need for a dedicated prevention trial [46:45]; Why Peter is optimistic about obicetrapib: cardiovascular benefits, Lp(a) reduction, and the path toward approval [50:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Lipids remain central to cardiovascular prevention. The 2026 ACC/AHA Dyslipidemia Guideline introduces several important shifts:   • PREVENT equations replace older ASCVD risk calculators • Lipoprotein(a) measurement recommended at least once in all adults • ApoB helps identify residual lipoprotein risk • Coronary artery calcium scoring refines treatment decisions • LDL-C targets return, with

Angela and special guest Dr. Darshan Shah, look at the polarising world of cardiovascular health, specifically demystifying the role of LDL cholesterol.  They challenge the traditional one-size-fits-all approach to statins, arguing that heart health must be viewed through the lens of individual biology—where factors like inflammation, genetic risk, and lifestyle can make the same LDL level a non-issue for one person and a crisis for another WHAT YOU WILL LEARN LDL is Not Always the Enemy: A high LDL reading alone doesn't guarantee heart disease; its impact depends on individual context The Power of ApoB and Lp(a): Traditional cholesterol panels are often insufficient; more modern biomarkers like ApoB(a superior risk marker) and Lp(a) (a genetic factor) provide a much clearer picture of cardiovascular risk. AI in Diagnostics: The Clearly scan uses AI to analyse CT angiograms, allowing doctors to see the actual buildup of both calcified and soft plaque in the coronary arteries rather than just guessing based on blood work. Precision Over Dogma: Because cardiovascular health is an "N-of-1" situation, interventions like statins or PCSK9 inhibitors should be based on actual arterial health TIMESTAMPS: 01:21 The LDL Controversy: An explanation of why cholesterol remains a polarizing topic and why it must be treated as an individual biology issue. 02:37 The Tale of Two Patients: A comparison of a healthy gym-goer with high LDL/zero plaque versus a high-stress professional with lower LDL/significant plaque. 04:13 Modern Biomarkers: A breakdown of the specific tests to ask for, including ApoB, HS-CRP, and the Clearly cardiovascular scan. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

What does real longevity actually look like? Is it the latest biohacking trend, or something much more foundational? In this episode, I sit down with Dr. Loren Marks, chiropractor and longevity-focused clinician, to discuss why the conversation around healthspan is rapidly becoming one of the most important topics in modern healthcare. Together, we explore how true longevity is less about chasing health fads and more about understanding and optimizing the body's fundamental physiological processes. Dr. Marks breaks down the difference between biohacking and sustainable longevity, emphasizing the importance of metabolic health, inflammation control, and personalized assessments. We discuss key biomarkers such as insulin and hsCRP, the role of muscle mass in aging well, and why balance training is one of the most overlooked strategies for preventing falls and maintaining independence later in life. If longevity is the healthcare conversation of the next decade, this episode offers a clear roadmap for practitioners and patients alike. From foundational metabolic markers to functional movement and personalized care, we explore how integrating modern science with clinical fundamentals can help people not just live longer, but live better.   Key takeaways: Longevity is rooted in physiological optimization rather than quick-fix biohacking techniques. Metabolic markers such as insulin, APOB, and HSCRP play crucial roles in determining health risks and should be part of regular health assessments. Muscle mass is pivotal for glucose disposal, fall prevention, and overall health, making strength training essential for longevity. Balance training can significantly reduce fall risks, a leading cause of serious injuries among older adults. More About Dr. Loren Marks: Dr. Loren Marks is a Manhattan-based Doctor of Chiropractic and board-certified Clinical Nutritionist with more than four decades of clinical experience guiding patients toward precision health, structural integrity, and long-term vitality. At his Midtown practice, Dr. Marks delivers executive-level health optimization through comprehensive metabolic analysis, advanced cardiovascular risk stratification, microbiome and gastrointestinal evaluation, hormone mapping, and precision structural care. His work integrates chiropractic medicine, functional nutrition, advanced blood chemistry interpretation, and non-invasive performance technologies into a cohesive, data-driven model of care. With a deep foundation in spinal biomechanics and neurophysiology, Dr. Marks brings extensive expertise in structural rehabilitation, chronic pain syndromes, neurologic function, and the relationship between biomechanical alignment and systemic health. His clinical approach recognizes that metabolic resilience, neurologic integrity, and structural stability are inseparable components of long-term performance and longevity. Dr. Marks is the author of a chapter in Arachnoiditis: The Evidence Revealed, edited by Antonio Aldrete, MD, and a contributing chapter author in Integrative Gastroenterology, edited by Gerard Mullin, MD, as part of the Andrew Weil integrative medicine series. His published work reflects a longstanding commitment to bridging structural medicine, gastrointestinal health, and systems-based clinical strategy. Known for synthesizing complex laboratory and clinical data into clear, strategic action plans, Dr. Marks focuses on identifying subtle patterns of dysfunction years before they manifest as overt disease. His philosophy is grounded in a core principle: sustainable longevity and peak performance are achieved not through isolated interventions, but through system-wide alignment — metabolic, neurologic, structural, and behavioral. Dr. Marks provides discreet, highly personalized care for individuals committed to measurable, evidence-informed health optimization. Licensed Doctor of Chiropractic in New York State. Board-Certified in Clinical Nutrition (DACBN). Website Instagram Connect with me! Website Instagram Facebook YouTube

High cholesterol is one of the most widely discussed—and established—risk factors in medicine. But reams of research now show that while it is key to cardiovascular risk, it is not the whole story.In this episode of A Whole New Level, editorial director Mike Haney sits down with Dr. Ronald Krauss, one of the world's leading lipid researchers and a pioneer in understanding how different forms of LDL—and the physiological factors around them—affect cardiovascular risk.Dr. Krauss explains why the basic link between cholesterol and heart disease is well established among experts—but also why the standard cholesterol panel often misses the deeper metabolic story. Drawing on decades of research, he walks through how lipoproteins, particle size, triglycerides, and metabolic health interact to determine whether cholesterol actually becomes dangerous.Along the way, the conversation explores why cardiovascular disease remains the leading killer despite statins and decades of research—and how factors like obesity, insulin resistance, and inflammation reshape the lipid landscape in ways that traditional tests may not capture.The result is a clearer framework for understanding cardiovascular risk: not just how much cholesterol is in the blood, but how it's being transported, how long those particles circulate, and what metabolic conditions are driving them.Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠https://levels.link/wnl⁠⁠In this episode, we coverWhy the cholesterol–heart disease link isn't actually controversial among researchersCholesterol vs. lipoproteins: why the particles carrying cholesterol matter more than the number itselfSmall dense LDL: how triglyceride metabolism produces the most harmful particlesApoB and particle counts: why many researchers prefer measuring particles instead of cholesterol massLipoprotein(a): the genetically driven risk factor affecting up to a third of the populationMetabolic syndrome: the cluster of conditions that amplifies cardiovascular riskWhy carbohydrates and metabolic dysfunction can drive harmful lipid patternsThe saturated fat debate: why food context and metabolic health matter more than simple fat categories

¿Qué sabemos realmente, a nivel molecular, sobre el efecto del aceite de oliva en la salud cardiovascular?Jesús de la Osada lleva más de treinta años investigando las bases moleculares de la aterosclerosis y el papel de los componentes de la dieta mediterránea en la salud cardiovascular. En este episodio repasa cómo se construye conocimiento riguroso en un área donde la divulgación de baja calidad abunda, y qué significa eso en términos de lo que podemos afirmar con fundamento sobre el aceite de oliva virgen extra.La investigación del grupo arrancó cuando los estudios disponibles medían únicamente colesterol total, un marcador tan poco específico que el aceite de oliva resultó neutro y quedó décadas fuera del foco. Con la llegada de modelos animales que reproducen aterosclerosis en semanas y el avance de la química analítica, el panorama cambió. El aceite de oliva virgen extra contiene cerca de 400 compuestos identificados. El candidato inicial, el ácido oleico por ser el componente mayoritario, fue descartado experimentalmente. El compuesto que concentra hoy el trabajo del grupo es el escualeno: el más abundante, el más estable durante el almacenamiento y el que se absorbe y acumula en órganos. Es además un intermediario universal en la biosíntesis de esteroles, lo que explica su presencia en organismos tan distintos como el olivo o el tiburón, y su coincidencia en las dos poblaciones con menor mortalidad cardiovascular históricamente documentada: la mediterránea y la japonesa.Estudiarlo de forma aislada presenta un problema importante: fuera de su matriz natural, el escualeno se oxida con facilidad. La solución que el grupo ha desarrollado en colaboración con el Instituto de Nanomateriales de Aragón es la encapsulación en nanopartículas que aíslan el compuesto y replican la protección que ejerce el propio aceite. En paralelo, trabajan con un aceite de oliva virgen enriquecido en escualeno y un compuesto fenólico, desarrollado junto a una empresa chipriota, cuyos resultados preliminares son prometedores.Dedicamos parte de la conversación a la diferencia entre evidencia in vitro y evidencia clínica, y por qué esa distinción es relevante para evaluar las afirmaciones que rodean a suplementos y nutracéuticos. El marco regulatorio para uso alimentario no exige demostrar eficacia, solo ausencia de toxicidad. Eso permite construir argumentos sobre mecanismos reales sin evidencia de que funcionen en humanos a las dosis habituales. No es necesariamente fraudulento, pero el salto entre ambas cosas rara vez se explicita.Hablamos también del estado actual del diagnóstico cardiovascular. Más allá del colesterol total y la distinción LDL/HDL, hay marcadores con mayor valor predictivo que no se usan de rutina: la Lp(a), el tamaño de las partículas de LDL, o la cuantificación de ApoB-100, que refleja el número de partículas en circulación independientemente del colesterol que transportan. La razón por la que estos marcadores no se incorporan de forma sistemática no es científica sino económica. Lo mismo ocurre con la farmacogenómica aplicada a estatinas: sabemos que los citocromos P450 implicados en su metabolismo tienen variantes con distinta actividad, pero la caracterización de cada paciente antes de prescribir sigue siendo la excepción, no la norma.Página Web del grupo: https://osada.unizar.esNuevos aceites: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.70223Escualeno: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201800136Aceite de oliva virgen: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201100668Nuevos modelos para estudio de aterosclerosis: https://www.imrpress.com/journal/FBL/11/1/10.2741/1852Si el episodio te ha resultado interesante, puedes apoyarlo dándole a like, suscribiéndote o compartiéndolo en tu plataforma habitual (Spotify, Apple Podcasts, iVoox, YouTube, etc.). Es un gesto que te cuesta muy poco y que ayuda muchísimo a que este podcast siga creciendo y llegue a más personas.

In dieser Episode spreche ich mit Prof. Ulrich Laufs, Direktor der Klinik für Kardiologie am Universitätsklinikum Leipzig und einer der führenden Experten auf dem Gebiet der Lipidologie.Cholesterin ist einerseits lebensnotwendiger Baustein unserer Zellen, gilt andererseits aber als Hauptverursacher für Herzinfarkte und Schlaganfälle. Doch was ist wissenschaftlicher Fakt und was ist Mythos? Wir räumen mit dem veralteten Bild vom „guten“ und „schlechten“ Cholesterin auf und analysieren, was die aktuelle Forschung über effektive Prävention und moderne Therapien sagt.In dieser Folge erfährst du:

Dr. Kim Brockenbrough: https://www.cardiavision.com/https://www.linkedin.com/in/kimberly-brockenbrough-md-1b321a123/https://www.instagram.com/kimbromd?ighsh=YjVpcDcwdHA3ejVvYour calcium score came back zero. You're in the clear, right? Not so fast.In this episode, Optispan Clinical Director Dr. Nicki Byrne sits down with Dr. Kim Brockenbrough, board-certified cardiovascular radiologist, 25-year veteran of vascular imaging, and CEO of CardiaVision, for a conversation that challenges one of the most common assumptions in preventive cardiology.If you care about cardiovascular longevity, and you should, because heart disease remains the leading killer, this is the imaging conversation you didn't know you needed.Timestamps:00:00 — Cold open: The 48-year-old runner with an 80% blockage and a zero calcium score00:54 — Dr. Nicki Byrne introduces Dr. Kim Brockenbrough & CardiaVision01:45 — Dr. Brockenbrough's background: 25 years of vascular imaging02:35 — Cardiovascular disease through a longevity lens: imaging vs. labs vs. functional testing03:24 — The lifecycle of plaque: from fatty deposits to rupture and heart attack04:21 — Why soft plaque is more dangerous than calcified plaque (SCOT-HEART 2020)05:14 — How calcium scores are used in clinical practice — and where they fall short06:18 — The only way to see soft plaque non-invasively: coronary CT angiography (CCTA)07:08 — Which populations are most at risk of a false sense of security from calcium scoring08:03 — What a CCTA can tell you that a calcium score can't09:43 — How often should patients follow up with repeat scans?10:28 — Higher vs. lower dose radiation protocols — and why Dr. Brockenbrough chooses higher dose11:17 — Risks of CCTA: contrast reactions, kidney considerations12:15 — Stress tests vs. CCTA: why a negative stress test is a very low bar13:21 — Soft plaque that isn't flow-limiting: small emboli, dementia, and congestive heart failure15:36 — Medications that reverse plaque: statins, PCSK9 inhibitors, and the LOCATE trial16:23 — LDL reduction and plaque regression: what the data shows17:08 — High-intensity statins vs. Repatha — tolerability, efficacy, and the price drop18:27 — When OptiSpan reaches for PCSK9 inhibitors: ApoB, LDL, Lp(a), ApoE4, and significant disease19:22 — Why a rising calcium score on a statin is exactly what you want to see20:25 — AI plaque quantification tools: promise, limitations, and validation concerns22:54 — Has AI ever changed Dr. Brockenbrough's read? A real-world case23:40 — FFR-CT, the ISCHEMIA trial, and why stenting asymptomatic patients is no longer standard of care25:25 — The future of cardiac imaging and the case for universal CCTA screening26:52 — The patient experience: what to expect at a CardiaVision CCTA appointment28:18 — Why seeing soft plaque changes patient behavior — the power of treating disease, not numbers29:49 — Bridging the gap between longevity medicine and traditional cardiology33:11 — Testosterone, the TRAVERSE trial, and what you should know about your coronaries first35:41 — What causes coronary artery disease beyond cholesterol: sugar, inflammation, gum disease37:07 — Image walkthrough: soft plaque vs. calcified plaque on a real CCTA41:36 — Where to find Dr. Brockenbrough and CardiaVision

Have you ever been told your labs are “normal” — but you don't feel normal?In this episode, I sit down with integrative and functional medicine physician Aaron Hartman, author of Uncurable, to unpack the dangerous gap between normal and optimal — especially for women in midlife.We cover:What lab reference ranges really meanThe cardiovascular markers every woman should know (hs-CRP, LDL particle number, Lp(a), ApoB, homocysteine)Why LDL alone is outdated thinkingThyroid testing beyond TSH (free T3, free T4, reverse T3, antibodies)Ferritin, B12, iodine & nutrient blind spotsEstrogen, progesterone & testosterone — when to start and what actually protects your brain and heartStatins, diabetes risk, and mitochondrial healthGut health, inflammation & autoimmune triggersWhy lifestyle is foundational — and where advanced longevity tools fit inDr. Hartman explains how heart disease begins decades before symptoms appear, why hormone replacement therapy dramatically reduces risk when used appropriately, and how women can advocate for themselves in a system that often dismisses midlife symptoms.If you care about your brain, your bones, your heart — and living strong into your 80s and 90s — this conversation is essential.Did you miss something? Check out the transcripts of the episode!You can find Aaron Hartman, MD at https://richmondfunctionalmedicine.com/Instagram https://www.instagram.com/aaronhartmanmd/His book, Uncurable: From Hopeless Diagnosis to Defying All Odds, is available where you buy books. _________________________________________If you're doing “all the right things” and still feel stuck, adding a layer of support may be an option. I've partnered with a trusted telehealth platform offering modern solutions for women in midlife—including micro-dosed GLP-1 and other peptide therapies. https://elliemd.com/michelefolan - Create a free account to view all products. Follow us on Instagram https://www.instagram.com/askingforafriend_pod/ ✨ Sign up for my weekly newsletter: https://michelefolanfasterway.myflodesk.com/i6i44jw4fq Like to connect? Email me at askingforafriendpodcast1@gmail.com Transcripts are created with AI and may not be perfectly accurate. Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your qualified healthcare provider with any questions regarding a medical condition.

What if your bloodwork is "normal"—but your health isn't optimized?     Lisa Fischer welcomes Regan Archibald back to explore how peptides are redefining longevity, metabolic health, and immune regulation. Instead of waiting for disease, Regan shares how comprehensive lab analysis can identify subtle imbalances in insulin, ferritin, thyroid antibodies, ApoB, and inflammatory markers—then match those findings with targeted peptide therapy.     They break down how peptides turn genes on and off, support muscle preservation, enhance neuroplasticity, improve sleep cycles, regulate stress hormones, and reduce systemic inflammation. The conversation also tackles safety, FDA regulation, compounding pharmacies, and why buying research peptides online can be risky. This episode is for anyone curious about epigenetics, advanced lab testing, and personalized health optimization beyond GLP-1 trends.     Link to the Little Rock Event: Link to event: https://agelessfuture.com/summit-26-03-20-little-rock/    

What does over 18 months of precision medicine actually look like in practice? In this episode of the Optispan Success Story Series, Dr. Matt Kaeberlein sits down with Carlos Pinto, a tech executive and early Optispan client, to trace his longitudinal health journey from metabolic warning signs to measurable, sustained transformation. Carlos shares how a decade of overlooked biomarkers, a post-pandemic health decline, and a single panic attack became the catalyst for a data-driven approach to his own biology. Together, he and Dr. Kaeberlein review real DEXA, lipid, metabolic, and environmental biomarker data, unpacking what moved the needle, what didn't, and why the answer was rarely simple. This conversation is a candid look at what it means to become your own best health advocate, not through quick fixes, but through personalized, longitudinal learning.Timestamps:0:00 – Cold open & highlights0:50 – Welcome & Carlos's background in tech leadership2:15 – How career ambition displaced health in his 20s and 30s3:39 – A panic attack as the turning point: connecting mental and physical health4:24 – A previous medical wellness program: what worked and what was missing6:34 – Arriving at OptiSpan: intention, mindset, and expectations7:15 – Gateway Day: comprehensive baseline testing and initial surprises8:51 – Early metabolic lessons: CGM data, glucose spikes, and dawn effect11:32 – Confronting white coat hypertension with 78 data points13:28 – How stress, sleep, and nutrition interact to drive metabolic dysfunction15:44 – Personal experimentation as methodology: berberine, time-restricted eating, and fish17:09 – Mercury toxicity from fish consumption: a case study in biomarker surveillance18:33 – Stress management protocols: walking, meditation, and measurable outcomes19:49 – Statin introduction: the role of medication as a tool, not a failure20:27 – DEXA results: visceral fat reduction, body fat loss, and lean mass gain24:17 – Lipid profile transformation: ApoB from ~115 to 70, LDL from 160 to 7425:57 – A1C trajectory and the complexity of glucose optimization30:01 – Reframing medication: proactive use vs. reactive disease management31:29 – Mercury biomarker deep dive: from 2.4 to 16 and back to 232:21 – Goals for the future: sustainability, muscle retention, and mental clarity36:30 – Lineage biological age algorithm: from mortality risk of 54 to 5239:27 – Closing reflections: health as a lifelong trajectory, not a program

Heart disease should be treated just like cancer, says guest Mike McConnell, an author and expert in preventive cardiology at Stanford: Detect and stage early, then treat aggressively. In his practice, McConnell focuses on using low-dose CT imaging for detecting early coronary artery disease. He also helped pioneer the use of AI to infer cardiovascular risk from retinal scans. Such non-invasive, consumer-friendly tools could expand prevention, personalize therapy, and cut heart attacks and strokes across the board, he says. “Everybody also deserves a proactive preventive cardiologist in their phone,” McConnell tells host Russ Altman of the latest approaches to heart disease on this episode of Stanford Engineering's The Future of Everything podcast. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu. Episode Reference Links: Stanford Profile: Michael V. McConnell, MD, MSEE Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook Chapters: (00:00:00) Introduction Russ Altman introduces guest Michael McConnell, a professor of cardiology at Stanford University. (00:03:02) Reframing Heart Disease Why coronary disease should be approached the same as cancer. (00:05:46) Core Risk Factors The key drivers of cardiovascular disease, and life's essential eight. (00:07:18) Coronary Artery Calcium Scoring How low-dose CT scanning detects disease before symptoms develop. (00:08:57) The Limits of Stress Testing Why traditional stress tests often miss early coronary disease. (00:10:18) AI in Cardiac Imaging Using AI to identify hidden risks in routine chest scans. (00:11:30) Retinal Imaging How AI analysis of retinal blood vessels can predict heart disease risk. (00:14:55) Detecting Risk Before Symptoms Why retinal and vascular changes occur long before clinical signs appear. (00:15:58) Staging Coronary Disease Using calcium scores to stage coronary disease and personalize treatment. (00:19:36) Direct-to-Consumer Prevention The rise of mobile health records, wearable devices, and AI tools. (00:22:23) Opportunities & System Challenges Balancing accessibility, guideline-based care, and healthcare system capacity. (00:25:26) AI-Powered Health Record Analysis The potential of automated reviews to identify silent risk factors. (00:27:41) Physician Adoption & System Friction Barriers to integrating early detection tools into clinical practice. (00:30:12) Advances in Treatment Overview of current cholesterol therapies and plaque stabilization. (00:33:31) Future In a Minute Rapid-fire Q&A: prevention, implementation science, and future hopes. (00:35:38) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Hormones regulate far more than your cycle. They shape cholesterol, glucose, brain energy, and metabolism. Here's what happens when estrogen signaling shifts. Hormones are messengers. Genes influence how those messages are received. And when estrogen begins to fluctuate or decline, your labs often shift right along with it. In this episode, Nikki Burnett breaks down how estrogen influences LDL, ApoB, insulin sensitivity, brain energy production, fat distribution, sleep quality, and inflammation. You'll learn why cholesterol and fasting glucose often rise during perimenopause and menopause, even when diet and exercise haven't changed. This conversation goes deeper than surface-level lab interpretation. Nikki explains how genetics shape lipid metabolism and fat storage, why women's brains are uniquely sensitive to estrogen changes, and how disrupted sleep can amplify metabolic dysfunction. She also clarifies the important differences between oral and transdermal hormone therapy and why delivery method matters. ⏱️ KEY MOMENTS

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How much can what you eat really influence your heart health — and how quickly can you improve your blood pressure or cholesterol through diet? In this episode of Health Matters, host Courtney Allison sits down with cardiologist Dr. Sean Mendez of NewYork-Presbyterian Brooklyn Methodist Hospital to break down the real connection between food and cardiovascular wellbeing. They explore what your health numbers mean — from blood pressure ranges to LDL cholesterol, triglycerides, HDL, and the emerging marker ApoB — and how these values signal current or future risk. Dr. Mendez explains how dietary shifts can lower LDL cholesterol by 3 to 15 percent and reduce blood pressure by several points, even without medication. He also discusses salt sensitivity, the impact of saturated fats and processed foods, and why soluble fiber, healthy fats, and whole foods can play a powerful role in improving cholesterol. The conversation dives into the DASH diet and the Mediterranean diet, outlining how each works, what they emphasize, and the evidence behind their ability to reduce blood pressure and overall cardiovascular risk. Dr. Mendez offers practical tips for getting started and key lifestyle factors that are essential for heart health.  Whether you're hoping to lower your numbers, prevent future heart issues, or simply make more informed choices at the grocery store, this episode provides clear, accessible guidance on building a heart‑healthy way of eating. Chapters: 01:13 – What Do Heart Health Numbers Mean? 04:33 – How Quickly Diet Changes Improve Labs 10:59 – How to Start Changing Eating Habits Key Topics Covered What cholesterol, blood pressure, triglycerides, HDL, LDL, and ApoB measure How these numbers relate to cardiovascular disease risk Healthy ranges for blood pressure and cholesterol How diet can lower LDL cholesterol and blood pressure How quickly lab results change after modifying eating habits The role of salt sensitivity and saturated fats in heart health Foods that help lower LDL, including soluble fiber and healthy fats The DASH diet: its structure, purpose, and evidence for lowering blood pressure The Mediterranean diet: core foods, flexibility, and cardiovascular benefits Differences between DASH and Mediterranean diets Practical starting points for improving eating habits Benefits of tracking food intake and identifying patterns Easy, heart‑healthy food and snack swaps Why lifestyle factors like sleep, stress, exercise, and limiting alcohol matter Common misconceptions about eating for heart health Why heart‑healthy eating is beneficial at every age Takeaway Message Small, consistent changes to your diet and lifestyle can meaningfully improve your heart health — at any age. Understanding your numbers (like LDL, blood pressure, and ApoB) empowers you to make targeted choices, and evidence‑based eating patterns such as the DASH or Mediterranean diet can lower risk over time. Even if medications are part of your care, diet, sleep, exercise, and stress management remain essential tools for protecting your heart. Expert Guest Dr. Sean Mendez is a non-invasive cardiologist at New York Presbyterian Brooklyn-Methodist Hospital and an assistant professor of clinical medicine at Weill Cornell Medicine. His clinical interests include preventive cardiology, valvular heart disease, and cardiovascular imaging, including echocardiography, stress testing, and vascular imaging. In addition to seeing patients in his outpatient clinic, he provides inpatient care in the cardiac care unit, cardiac telemetry unit, and consultative cardiology service. Dr. Mendez is passionate about providing his patients with the highest-quality, comprehensive cardiovascular care. He addresses all aspects of health to prevent the development and progression of cardiovascular disease. Dr. Mendez, a native of Buffalo, New York, graduated magna cum laude from the University of Alabama with a bachelor's degree in both biology and mathematics. He attended medical school at the University at Buffalo, where he was inducted into the prestigious Alpha Omega Alpha Medical Society. Dr. Mendez then completed his residency in internal medicine at Massachusetts General Hospital/Harvard Medical School.  He then completed his fellowship in cardiology at the Mount Sinai Hospital, where he was chief fellow. For more health and wellness news, visit NewYork-Presbyterian's Health Matters website. 

"Since the 80s, we've been brainwashed to believe that eggs are bad for us, butter is bad for us, dairy is bad for us, red meat is bad for us. And it's just not true." If you've been told your cholesterol is "too high"... if you're on a statin drug and wondering if it's actually helping... if you care about preventing heart disease instead of just managing it... this episode is your wake-up call. It's Heart Health Month, and Dr. Terri is cutting through decades of misinformation to reveal what's REALLY driving cardiovascular disease — and it's not cholesterol. From the gut-heart connection to the six hormones that could save your life, this is the heart health conversation your doctor probably isn't having with you. Here's the truth: "The highest gross revenue producing drug in the history of drugs — billions of dollars — and since they've come out in the 80s, cardiovascular disease rates and death from cardiovascular disease have actually gotten worse, not better." WHAT YOU'LL DISCOVER: → Why heart disease is a disease of INFLAMMATION, not cholesterol → The shocking truth about statin drugs — and why heart disease has gotten WORSE since the 80s → How cholesterol-lowering drugs are literally shrinking your brain (the brain is 70% cholesterol) → The connection between statins, insulin resistance, and Alzheimer's (now called Type 3 Diabetes) → Why "all disease begins in the gut" — Hippocrates said it 2,000 years ago and it's still true → How estradiol reduced cardiovascular disease progression by 50% in women who already had plaque → Why testosterone is powerfully protective for men's hearts (not just for energy and muscle) → The one organ that can't make its own T3 thyroid hormone — your heart → Why your "normal" lab ranges are based on a sick population (and what optimal ACTUALLY looks like) → The phone scrolling habit that's destroying your melatonin AND your heart health → The inverse relationship between cortisol and DHEA that's wrecking your cardiovascular system → The vitamin D level that triggers a 5x cancer risk and 160% increased cardiovascular disease risk → The 6 hormones you need optimized for true heart disease prevention This isn't about managing heart disease with more prescriptions. It's about understanding the root cause — inflammation — and optimizing the hormones your body needs to protect itself. YOUR ACTION STEPS: Get a deep-dive lipid panel (particle size, ApoA, ApoB), check your hormone levels, ask about a coronary artery calcium score, and focus on OPTIMAL — not just "normal." TIMESTAMPS: 0:00 - Intro: It's Heart Health Month 2:15 - Heart disease is NOT a cholesterol problem 4:20 - The statin drug soapbox: billions in revenue, worse outcomes 6:40 - How statins are connected to Alzheimer's and insulin resistance 7:55 - It all begins in the gut: inflammation and lipid polysaccharides 9:05 - The one statin study — and why it doesn't apply to everyone 10:20 - Estrogen: a powerfully protective anti-inflammatory molecule 11:25 - The study showing 50% reduction in plaque progression with estrogen 14:05 - Testosterone: protective for cardiovascular disease in men 14:45 - Thyroid: the heart can't make its own T3 16:15 - Why "normal" lab ranges are based on sick populations 17:15 - Optimal Free T3 levels and what pediatric data actually shows 17:50 - Melatonin: the hormone you're destroying with your phone 19:10 - DHEA: the cortisol-DHEA inverse relationship 20:25 - Vitamin D: the hormone-like molecule with massive cardiovascular impact 21:20 - Recap: The 6 hormones for heart disease prevention ---- The Dr. Terri Show is presented by EVEXIAS Health Solutions. For more, visit: https://www.evexias.com ---- Connect with Dr. Terri DeNeui, DNP:

Try Fitness Lab to get personalized daily coaching on nutrition, training, and biofeedback that adapts to how you want to train, whether you're focused on lifting, endurance, or both. Get 20% off through February 17:http://bit.ly/fitness-lab-pod20--You've been told cardio is for a healthy heart and lifting weights is for building muscle. But what if strength training is itself a form of cardio?What if you're ignoring one of the most effective tools for lowering blood pressure, improving cholesterol, and reducing your risk of heart disease?Philip breaks down the evidence showing that strength training lowers blood pressure on par with first-line medication, improves HDL and LDL cholesterol, enhances insulin sensitivity, and reduces visceral fat, all independent of cardio. You'll learn why your muscle tissue functions as a metabolic organ that regulates blood sugar, why adults who lift have up to 17% lower cardiovascular disease risk, and how to program your lifting sessions to get a real cardiovascular training effect without adding time on the treadmill. Philip also answers listener Jack R.'s question comparing cardio and lifting head-to-head for fat loss, muscle building, and long-term sustainability after 40. Whether you're already strength training over 40 or still treating the weight room as optional for heart health and longevity, this episode gives you the evidence-based case for making lifting your foundation.Timestamps:0:00 - Why "cardio for your heart" is incomplete 1:43 - The 2023 AHA statement about lifting weights and heart health 5:28 - How strength training lowers blood pressure as much as medication 7:11 - Nitric oxide, arterial stiffness, and improved blood vessels 9:27 - Cholesterol, triglycerides, and ApoB improvements 13:17 - Why muscle is your most powerful metabolic organ for insulin and blood sugar 15:20 - Cardio vs. lifting for fat loss and building muscle after 40 18:01 - Visceral fat, inflammation, and menopause 19:47 - Can lifting weights improve VO2max? 22:01 - Longevity data and the minimum dose of strength training for heart health 23:57 - How to get cardiovascular benefits WITHOUT extra cardio 26:04 - Rest periods, compound movements, and rep ranges for heart-healthy lifting 28:59 - Weekly template combining strength training and walking 30:59 - Physical reserve and why strength protects your heart all day 33:04 - Bonus: 10-second heart rate recovery test you can do between sets

Are you frustrated with conventional medicine focusing on symptom management instead of root causes?   In this episode of the Boss Body Podcast, I sit down with Dr. Michele Neil-Sherwood, board-certified internal medicine physician and functional medicine expert, to unpack what's really driving chronic illness today.   We dive into advanced cardiovascular inflammation testing (ApoB, LP(a), LDL particle size), mold toxicity, mast cell activation, epigenetics, peptides like BPC-157 and Thymosin Alpha-1, and how molecular hydrogen and red light therapy support true healing.   Dr. Neil-Sherwood shares her powerful journey from corporate medicine to building a root-cause practice focused on authentic longevity — not just living longer, but living stronger.   If you want deeper answers, better labs, and a more strategic approach to your health — this episode is for you.  

On this episode of Vitality Radio, Jared takes a closer look at the cholesterol conversation and the widespread use of statin medications through a functional health lens. Rather than relying on fear or headlines, he explores how cholesterol numbers are interpreted, the difference between risk markers and root causes, and why metabolic health, inflammation, and lifestyle factors may play a larger role in long-term heart wellness. Jared also explains concepts like absolute risk, number needed to treat (NNT), and why informed decision-making matters when evaluating any health strategy. This episode encourages listeners to ask better questions, seek clarity, and consider a comprehensive approach to cardiovascular health that includes nutrition, movement, and targeted supplementation. As always, this discussion is educational and designed to empower you with information so you can make the best decisions for your personal health journey.Products:N.O. Cardio BoostVital 5 Omega-3 + AntioxidantsNatural Factors Rx Omega-3Natural Factors BerberineSolaray BerberineVital 5 Magnesium BisglycinateAdditional Information:#563: Bad Medicine: Why Your Gallbladder Isn't Disposable & How to Thrive With or Without It #332: Cholesterol Controversy - Jared's Interview on Inside The Aisle with Niki WolfeDr. Aseem MalhotraDr. Uffe RavnskovDr. Zoë HarcombeDr. Malcolm KendrickDr. David DiamondVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

In this episode we discuss the latest research the medical industry may not be telling you about your heart health. While statins dominate the conversation, groundbreaking research suggests cholesterol isn't the true villain—and your body actually needs it to thrive. If you're tired of feeling powerless over your health choices or overwhelmed by conflicting advice, this episode with Dr. Ben Schwartz is your game-changer. From prevention to disease reversal to treatment, we discuss it all, and with heart disease being the #1 killer of Amerians, you can't afford to stay uninformed.Timestamps:00:00 - Welcome and episode overview on heart health02:00 - Why heart disease remains the leading killer in America04:00 - Limitations of standard cholesterol tests and the need for advanced panels06:00 - How inflammation influences cardiovascular risk08:00 - Lifestyle factors: diet, sleep, stress management10:00 - Debunking cholesterol myths and the protective role of LDL12:00 - When statins may cause more harm than good15:00 - Natural supplements: red yeast rice and other alternatives18:00 - The significance of inflammation markers like APO-B, CRP20:00 - How emotional stress impacts the heart22:00 - The emerging science of infrared saunas and heat therapy25:00 - Recognizing early signs of a heart attack: symptoms and actions30:00 - How integrative medicine approaches can supplement conventional care35:00 - The importance of personalized risk assessment40:00 - Challenging the stories of the “big pharma” and industry influence44:00 - Practical steps to optimize heart health today50:00 - Resources, books, and tools for deeper understanding55:00 - Final encouragement: take ownership, be proactive, and stay informedResources & Links:Benton Integrative - www.bentonintegrative.com"First Do No Pharm" Film — nopharmfilm.comInfrared Sauna - www.Relaxsaunas.com (Use code: justthink200 for discount)

In this episode of Sisterhood of S.W.E.A.T., Linda Mitchell sits down with Dr. John Osborne, board-certified cardiologist, lipidologist, and founder of Clear Cardio, to challenge conventional thinking around cholesterol and heart disease. Dr. Osborne explains why LDL cholesterol alone is not a reliable standalone marker for cardiovascular disease and why focusing only on traditional lab numbers can create a false sense of security. He shares how plaque can quietly develop for decades before symptoms appear — and why the first symptom for many people is a heart attack or sudden cardiac event. The conversation explores the evolution of cardiac imaging, the role of ApoB and lipoprotein(a) in risk assessment, and how advanced cardiac CT combined with artificial intelligence now allows physicians to detect, measure, and track plaque in ways that were previously impossible. This episode reframes heart disease as something that can be identified early — and potentially prevented — when the right tools are used. What We Talk About in This Episode Why LDL cholesterol alone does not tell the full story The difference between risk factors and actual disease How ApoB improves cardiovascular risk assessment Why lipoprotein(a) is genetic and should be tested at least once The limits of traditional stress testing How plaque forms in the arterial wall decades before symptoms Calcium scoring versus full cardiac CT imaging How AI is transforming plaque detection and measurement Whether arterial plaque can be slowed or reversed The real role of statins and other cholesterol-lowering tools Why you cannot out-train genetics The one scan adults over 40 should consider Quotes from This Episode Cholesterol floating in your bloodstream does not tell me if it is sticking. Risk is not disease. The first question should be: do you have plaque? Half of men and two-thirds of women, their first symptom of heart disease is a heart attack or death. The problem is not that we cannot treat plaque. The problem is that we are not looking for it early enough. Early detection for heart disease should be as routine as screening for cancer. Connect with Dr. John Osborne Clear Cardio https://clearcardio.com Clear Cardio – Powers of Prevention YouTube Channel https://www.youtube.com/@ClearCardio Learn more about Cardiac CT and AI plaque analysis https://clearcardio.com/services/ Contact and Locations (Texas, Chicago, expanding to New York) https://clearcardio.com/contact/  

HEALTH NEWS A Simple Diet Change Could Slow Liver Cancer Brief, intensive exercise helps patients with panic disorder more than standard care Lucid dreaming could be used for mental health therapy, new study says US cancer institute studying ivermectin's ‘ability to kill cancer cells Too many saturated fats may be more harmful than too many refined carbohydrates.    Clips   Andrew Bridgen - https://x.com/ABridgen/status/2020573528571977993?s=20 MAHA Alliance Mike Tyson Super Bowl Commercial - https://www.youtube.com/watch?v=jg1SjFt1a_U   KETO DIET RISKS    The rationale for Keto Diet by its advocates Restricting carbohydrates, suppressing insulin and ketosis will lead to better metabolic heath, increase weight loss, reduce inflammation, and protect from chronic diseases.   Keto Claim: Carbohydrates raise insulin leading to fat storage – keto lowers insulin and burns body fat better Debunking: Ketosis is a metabolic state and not a health outcome. For example ketones can be elevated by very long fasting, starvation, different illnesses and uncontrolled diabetes.   Keto Claim: By minimizing carbs keto stabilizes blood sugar, reduce insulin spikes, and improve insulin sensitivity that benefits those with type 2 diabetes Debunked: This claim contradicts the evidence of induced hepatic insulin resistance and glucose intolerance in longer-term studies. In animal models, keto diets impair blood sugar regulation within several days, which shows harm for metabolic health.   Keto Claim: Ketones are seen as “clean” fuel that advocates claim are anti inflammatory and neuroprotective. Believe that this along with ketosis lowers triglycerides, raises HDL cholesterol, and improves lipid profiles. They argue that the increase in LDL cholesterol is benign. Claim saturated fats are harmless if carbs are low Debunked:  This claim is undermined by the increased LDL cholesterol, triglycerides, and cardiovascular risks from saturated fats in animal products. Meta-analyses show no long-term lipid improvements from keto diets. Rather this is the risk in elevated low-density lipoprotein and very-low-density lipoproteins that increase cardiovascular disease  Also, insulin reduction does not override the quality of fat. LDL cholesterol and ApoB, as well as atherosclerosis, increase significantly on an animal based diet. Saturated fat still remains a causal factor for cardiovascular disease.   Keto Claim: High protein and fat increases satiety and therefore reduces hunger Debunking: Weight loss is primarily from reduced intake due to satiety, not fat-burning efficiency. Long-term keto adherence often leads to weight regain with no significant sustained benefits for visceral fat or appetite control. hort term weight loss is not same as long term benefits. A study shows that weight loss at 3-6 months on a keto diet disappears by 12 months   Keto Claim: It enhances brain function and energy that then improves mental clarity and mood. Argue that animal products like eggs and organ meats provides choline and other nutrients for brain health. Debunked: There is no strong evidence for this claim. In fact keto's nutrient deficiencies and lack of fiber in the long term can lead to fatigue, constipation and in women neural tubal defects. Keto's claims are only based on short term trials.    Keto Claim: Use the evolutionary argument that humans evolved eating meat and fat – same argument the paleo folks used. Therefore, they believe keto diets align with human biology Debunked: A big study in Science in 2025 analyzed tooth enamel from skeletons of some of our oldest human ancestors, 3.5 million years ago, and found they ate predominately a plant based diet with no substantial sigh of mammalian meat. The isotopes matched herbivores (fruits, leaves and grasses, tubers, nuts, other vegetation) not carnivores.     Keto Diet Risks   It is worth noting, according to the Northwestern University Health site, there is a sizable drop out rate of participants in keto trials.   Although, there are studies that show keto does what it claims in the short term, there are no long-term human data to support their claims that an animal-based diet does this efficiently.   Important, research leans in the direction to indicate that keto's benefits – especially weight loss and glucose reduction, are transient and may not be directly related to animal food consumption itself but rather to calorie reduction and limiting glycogen.   Long term prospective studies and systematic meta analysis evaluations consistently show high red meat consumption, full-fat dairy and animal fats are associated with the following medical conditions. This is true even when carbohydrate intake is low   A good thorough study in JAMA shows that unprocessed red meat mildly increases all cause mortality – about 3-5% per 100 grams meat per day   High red and processed meat consumption increases carcinogenic N-nitroso compounds and heterocyclic amines that raise cancer risks by up to 18% per 50-100 grams/day – from meta analysis in the European Journal of Epidemiology   Dairy increases IGF-1 levels thereby too much calcium also suppressing Vitamin D and elevating prostate cancer risks by 79% per 400 gram dairy per day. Worse for processed meats that inreases risk by 21% per 20 grams/day – American Journal of Epidemiology   Red meat is linked to hormonal disruptions and carcinogens contributing breast cancer – European Journal of Cancer   Total unprocessed red meat consumption shows a modest 5% risk in pancreatic cancer per 100 grams/day. – From journal Clinical Nutrition   Many meta-analyses on meats have a relationship to stomach/gastric cancer, but processed meats are worse than unprocessed red meat. From study in Nutrients – 24 studies showed unprocessed red meat associated with gastric cancer by about 25% increase risk for every 100 grams/day.   Unprocessed red meat is linked to an 11% higher risk in overall cardiovascular disease risk due to inflammation and endothelial dysfunction. – from European Heart Journal   Saturated fats in meats increases non-HDL cholesterol and blood pressure and raises the risks of ischemic heart disease by 119% per 100 grams/day red meat – from American J Clinical Nutrition   Red meat diets reduce LDL Cholesterol much less than plant proteins and thereby increase atherosclerosis risks – from the journal Circulation   Red meats (an processed meats also in this study) contributes to insulin resistance via heme iron and raises Type 2 diabetes risks by up to 51% per 50 grams/day – International Journal Environmental Research in Public Health   Saturated fats in unprocessed red meat has a modest positive 12% increase with stroke risk – From  European Heart Journal Unprocessed poultry consumption shows a modest 4% increase in incident cardiovascular events per 100 grams/day. This is believed to be due to arachidonic acid poultry – in JAMA   Red meat contributes to sodium and saturated fat intact raising hypertension conditions by 14% per 50-100 gram/day – from journal Advanced Nutrition   Saturated fats from animal products cause lipotoxicity and insulin resistance, that promotes hepatic fat accumulation leading to non-alcoholic fatty liver disease – from Cardiovascular Development and Disease   High animal protein increases urinary calcium and acid overload leading to the formation of kidney stones – from the journal Nutrient   Animal-heavy diets have low fiber and micronutrient intake that contribute to nutrient deficiencies. Also causes constipation that can lead to immune system issues. – from the journal Nutrients   Red meat, dairy, and eggs disrupts the gut metabolism of carnitine and choline. This promotes TMAO plaque formation and inflammation that leads to atherosclerosis. – from Journal of Cardiovascular Development.   Although unprocessed meat consumption has not been adequately associated with dementia and Alzheimer's – yes, processed meats do – there are studies showing red meat is associated with “subjective cognitive decline” (SCD) which is related to precursors to dementia and Alzheimer's. A study in journal Neurology  links unprocessed red meat eaten at 1 or more servings per day to 16% higher risk in SCD.   High caloric density from saturated animal fats displaces fiber that contributes to weight gain obesity. From Neal Barnard in the American Journal of Clinical Nutrition   Animal products transmit prions that are associated with neurodegenerative disorders.  Proinflammatory compounds like TMAO are linked to neurological risks. – in International Journal of Molecular Science

Subscribe to AGE BETTER CHEAT SHEET Newsletter on Substack HERE   PRINT THIS AND TAKE IT WITH YOU TO YOUR NEXT ANNUAL PHYSICAL EXAM:   ESSENTIAL BLOOD WORK SCREENING TESTS CHEAT SHEET   February is AMERICAN HEART MONTH, so we're replaying this solo episode where I dive into the essential blood tests and health screenings every postmenopausal woman should ask about during your annual physical. Drawing on expert insights from past episodes, I talk through why it's crucial to go beyond routine tests and discuss additional screenings that can help detect potential health risks early.   WHAT I COVER IN THIS EPISODE:   - The importance of the lipid panel for understanding heart health.   - How the Apolipoprotein B (ApoB) test provides a more accurate cardiovascular risk assessment.   - Why high levels of C-reactive Protein (CrP) can indicate dangerous inflammation levels.   - The critical role of Vitamin D for bone and immune health, especially in midlife women.   - How regular blood glucose testing can help catch diabetes early.   - The significance of blood pressure monitoring for heart disease prevention.   - Why women should prioritize bone density tests to prevent osteoporosis.   - The importance of monitoring  waist circumference as an indicator of health risks.   - The need for regular cancer screenings, including Pap smears, mammograms, and colonoscopies, for early detection.   - Regular cancer screenings are essential for early detection.   KEY LINKS TO LEARN MORE:  Learn more about the ApoB test HERE  Learn more about the LP(a) test HERE    Learn more about inflammation HERE   Learn more about heart health and atrial fibrillation HERE   Learn more about blood glucose and insulin resistance HERE   CONNECT WITH ME:  Instagram: @BarbaraHannahGrufferman     X/Twitter: @BGrufferman   Facebook: @BarbaraHannahGruffermanAuthor   Please Rate & Review the Show!     If you enjoyed today's episode, please consider leaving a review or sharing it with someone who would benefit from these essential health tips.   Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife health is about far more than a single lab value. In this episode, we talked about how hormones, muscle mass, cholesterol, and inflammation influence long term heart and metabolic health. If you've ever felt overwhelmed or confused by what to focus on, we're bringing the clarity and direction to make it easier on you!Timestamps:[1:50] Welcome[11:52] I saw a post that said muscles in our legs help us have longevity and our calf muscles are like the second heart in the body. I'm assuming there's some truth, but does that just mean to continue to strike train and to walk?[24:56] How do you know if you're in peri-menopause? I feel like everything is a symptom.[37:24] What are the pros and cons of muscle splits vs. whole body workouts?[45:25] What dietary guidance do you have for lowering high total cholesterol? Episode Links:Kicking Back Cognitive Aging: Leg Power Predicts Cognitive Aging after 10 Years in Older Female TwinsSeeking Health DAO enzymeSeeking Health Histamine ProbioticThyroid Markers to check: TSH, Free T4, Free T3, Thyroid peroxidase antibodies (TPO), Thyroglobulin antibodies (TGAb)Additional cholesterol markers to check: ApoB, LDL-P, hs-CRP, fasting insulinSponsors:Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.Go to getkion.com/wellfed to get 20% off your order. Go to http://mdlogichealth.com/wfcolostrum , and use coupon code WFC15 for 15% off. You can also use code WELLFED for 10% off site wide on all MD Logic Products. Go to wellminerals.us/vitaminc and use code WELLFED to get 10% off your order.

Dr. Will Haas, MD, MBA is redefining what it means to age well. He is the Founder and CEO of VYVE Wellness in Charlotte, NC, where he helps high-achieving professionals reclaim energy, focus, and vitality through cellular optimization. Board-certified in Integrative and Family Medicine, Dr. Haas blends advanced therapies—IV nutrient infusions, therapeutic peptides, hyperbaric oxygen, and red light therapy—to deliver measurable results that help patients feel decades younger. Beyond VYVE, he co-founded OvulifeMD, creating natural fertility protocols, and serves as Chief Medical Officer at Infusive, supporting wellness practices nationwide. His expertise has been featured in Men'sJournal, Daily Mail, Yahoo Life, and Woman's World Magazine. Passionate about bridging science with practical results, Dr. Haas empowers high-performers who want more than just longevity—they want their best years ahead of them. Dr. Will Haas Vroom Vroom Veer Summary Journey to Integrative Medicine William shared his journey from medical school to finding his passion in integrative medicine, which focuses on using a variety of healing modalities to optimize health. He initially struggled with the conventional approach to medicine, which primarily focuses on treating diseases, and decided to pursue business studies during his medical training. However, a personal loss led him to fulfill his father's dying wish to complete his medical degree. William eventually found his calling in integrative medicine, which he believes should be the standard approach to healthcare, combining the best of conventional and alternative treatments. Cellular Optimization and Health Strategies Jeffery and William discussed the concept of cellular optimization and the importance of addressing toxins and oxidative stress in the body. They explored how factors like poor diet, lack of sleep, and environmental exposure can contribute to cellular damage and reduced energy levels. Jeffery shared his personal experience of reducing sugar and processed foods intake, which led to improved health and well-being. They also touched on the idea of getting a CT scan for a calcium score as part of a proactive approach to prevent heart attacks. Cardiovascular Health Assessment Strategies Jeffery and William discussed cardiovascular health, diagnostic tests, and therapeutic peptides. William explained the importance of assessing inflammation levels, homocysteine, and other markers to evaluate heart attack risk. They talked about the benefits of advanced lipid panels and the role of Apo B and oxidized LDL in predicting cardiovascular events. William shared a success story of a patient who improved his health through dietary changes, gut healing, and IV nutrient therapies. They also briefly discussed the potential of therapeutic peptides under medical supervision. Connections Website

We have another short-form, live YouTube episode today, where I dive into questions from listeners. Recently, the most frequently asked questions have been about cholesterol, likely because I often reference my podcast series with Dr. Tom Dayspring, a renowned lipidologist and menopause expert. Join me today to clear away some more of the confusion surrounding cholesterol. IN THIS EPISODE, YOU WILL LEARN: Why comprehensive lipid testing rather than standard testing is essential, post-menopause How menopause impacts women's lipid and triglyceride levels The roles APO B and Lp(a) play in assessing cardiac risk How the cardiac risk of women increases as estrogen declines The cardiac health benefits of monitoring lipids and considering HRT within the first six years of menopause What research studies reveal about how menopause influences cardiovascular risk Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Episodes with Dr. Thomas Dayspring: Episode 336: Lipid Masterclass: An Introduction to Lipids and Cholesterol with Dr. Thomas Dayspring Episode 344: Lipid Masterclass: A Deep Dive into Our Cardiovascular Needs with Thomas Dayspring Episode 352: Lipid Masterclass: Apo-B, Labs and Women's Heart Health with Thomas Dayspring Episode 495: Are You At Risk for Dementia? – The Most Overlooked Cholesterol Marker You Need to Know with Dr. Thomas Dayspring

In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your perimenopausal years can make all the difference for long-term health. Dr. Shepard shares the essential labs she runs on patients including ApoB, HbA1c, and thyroid optimization, plus the longevity metrics women should be tracking.We also get into supplement recommendations including why she recommends 10 grams of creatine daily, the role of inflammation in aging, and how estrogen is naturally anti-inflammatory which is why women see increased cardiovascular risk and metabolic dysfunction after menopause.Kayla's social + website:Instagram:  kaylabarnesTikTok:  femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comSpotify: https://open.spotify.com/show/4OLWWn2...Apple: https://podcasts.apple.com/us/podcast...Follow Her Female Protocol: https://www.protocol.kaylabarnes.comDr. Jessica Shepherd's social + website:Website: https://www.jessicashepherdmd.com/Instagram: https://www.instagram.com/jessicashepherdmd/Transform Your Health: https://eudemonia.net/?utm_source=podcast&utm_medium=kayla-podcast&utm_campaign=jessica-shepherd

Show notes: (0:00) Intro (0:49) Dr. Shah's background and personal health crisis (4:55) The most important biomarkers: hs-CRP, A1C, ApoB (7:46) How to track inflammation and metabolic health (13:00) Home tools: bioimpedance scale, grip strength meter (21:09) Nutrition basics: just cut ultra-processed foods (27:09) Hidden toxins in your air, water, and skincare (34:37) Longevity circuit: sauna, cryotherapy, hyperbaric oxygen (38:11) Therapeutic plasma exchange and next-gen biohacking (40:01) Dr. Shah's top 3 health tips anyone can start today (41:18) Where to find Dr. Shah (42:11) Outro Who is Dr. Darshan Shah?   Darshan Shah, MD is a health and wellness specialist, well-known, board-certified surgeon, published author, tech entrepreneur, and founder and CEO of Beautologie and Next Health. As an expert on all body systems, he has performed over 10,000 surgical procedures, including trauma surgery, general surgery and plastic/reconstructive procedures. As a health and wellness specialist, he has advised thousands of patients on how to optimize their well-being and extend their lifespan, culminating in the creation of Next Health, the first health optimization and longevity center to offer life-extending and enhancing technology and treatments in a beautiful, welcoming environment.   Connect with Dr. Shah Website: https://www.drshah.com/ LinkedIn: https://www.linkedin.com/in/darshanshahmd IG: https://www.instagram.com/darshanshahmd/   Grab your free Biomarker guide: https://www.drshah.com/biomarkers   Tune in: https://www.drshah.com/extend Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram

In this episode of Wellness at the Speed of Light, Dr. Stefano Sinicropi speaks with Dr. Michael Richman, a double board-certified cardiothoracic surgeon with deep expertise in lipidology and cardiovascular prevention. They unpack why cardiovascular disease remains the leading cause of death for both men and women, and why many people labeled “low risk” are still vulnerable to heart attack or stroke. This audio conversation focuses on how atherosclerosis develops over time, the major drivers of cardiovascular risk, and why genetics play a larger role than most people realize. Dr. Richman explains the practical difference between standard cholesterol testing and particle-based measurements such as LDL-P and ApoB, and why these tests can help identify risk earlier and more accurately. They also address the nocebo effect and the way health misinformation shapes patient beliefs and decision-making. The discussion covers the evidence behind statins, including plaque stabilization and inflammation, as well as common questions about omega-3 fatty acids, niacin, red yeast rice, and calcium scoring. The goal is to give listeners a clearer framework for understanding cardiovascular risk, asking better questions in clinical settings, and taking informed, prevention-focused steps without relying on hype or trends. Guest: Dr. Michael Richman, MD, double board-certified cardiothoracic surgeon and lipidology expert.

Extreme diets dominate social media, but what actually happens inside your body when you follow them? In this episode, registered dietitian Andres Ayesta shares the results of a 60-day self-experiment comparing a carnivore diet with a whole-foods, minimally processed approach. Using lab testing, DEXA scans, and behavioral science, he reveals what truly changes—and what doesn't—when it comes to weight, body composition, energy, and long-term health as we age. Andres Ayesta is a registered dietitian, sports nutritionist, and founder of Planos Nutrition. With over 12 years of experience, he helps busy professionals over 30 lose fat, improve energy, and build sustainable habits using evidence-based nutrition and behavior change strategies. His work bridges clinical science with real-world practicality.  Episode Timeline 00:00 — Introduction and why this experiment matters  03:10 — Carnivore vs whole foods: defining the diets  08:45 — Designing a real-world, controlled self-experiment  15:30 — Energy, hunger, and the keto adaptation phase  21:30 — Lab results: cholesterol, ApoB, and liver markers  27:45 — DEXA scan findings and body composition truth  33:30 — Sustainability, behavior, and why diets fail  38:30 — The Core Five habits for lasting lifestyle change  44:00 — One action step listeners can start this week   Action Steps:  Download Guide to Nature's Coloful Antioxidants  Subscribe to Growing Older Living Younger on your favorite podcast platform and leave a review to help others discover the show.  Join the Growing Older Living Younger Community Connect with Dr. Gillian Lockitch at ASKDRGILL Connect with the Guest Instagram: https://www.instagram.com/andresayesta YouTube: https://www.youtube.com/@andresayesta TikTok: https://www.tiktok.com/@andresthedietitian LinkedIn: https://www.linkedin.com/in/andresayesta Website: https://planosnutrition.com/  

A dislipidemia deixou de ser um tema restrito a “colesterol alto” e a Diretriz Brasileira de 2025 veio para deixar bem claro que o foco é prevenção da aterosclerose e suas repercussões em desfechos cardiovasculares!No DozeCast #208, Victor Bemfica e Diandro Mota discutem os principais destaques da nova diretriz e o que, de fato, muda na prática clínica.Falamos sobre:• Atualizações na estratificação de risco e tomada de decisão clínica• Metas lipídicas e marcadores adicionais (não-HDL, ApoB, Lp(a))• Estratégias de tratamento: intensificação precoce e terapias combinadas quando indicado• Papel das terapias hipolipemiantes modernas: anti-PCSK9, inclisiran, ácido bempedoico, entre outras • Condutas em populações específicas (diabetes, DRC, idosos e alto risco)

Today, I'm joined by the deeply thoughtful and refreshingly honest Dr. Sanjay Bhojraj, a self-described "curious cardiologist" who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it?   Episode Timestamps: Welcome to Longevity & episode setup … 00:00:00 Dr. Bhojraj's shift from ER cardiology to prevention … 00:06:30 Why most heart attacks aren't caused by big blockages … 00:09:15 Stress, nervous system load & heart attack risk … 00:13:10 CIMT explained: what it measures (and what it misses) … 00:26:40 Calcium scores vs CT angiograms … 00:35:45 CLEERLY scan: seeing dangerous soft plaque … 00:38:45 Can plaque actually regress? … 00:41:55 When heart scans make patients less afraid … 00:44:05 When should you test — even without symptoms? … 00:45:50 Why age 45 is a major cardiovascular inflection point … 00:47:10 Hormones, estrogen loss & women's heart risk … 00:50:10 Why cardiology still misunderstands women … 00:54:30 Small dense LDL, ApoB & oxidized cholesterol … 01:02:00 Why fixing inflammation matters more than numbers … 01:05:50   Our Amazing Sponsors: Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25%   Mitopure® Longevity Gummies are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at Timeline.com/Nat2026 *Special deal through January 2026.   PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Feeling “fine” is not a plan. We sit down with Dr Sandeep Palakodeti —an Ivy League–trained internist who left elite institutions—to unpack why so much of healthcare reacts to disease instead of building durable health, and how treating your body like your ultimate asset can change the arc of your life. We dig into the core four foundations (sleep, diet, exercise, relationships), the hidden risks behind “normal for your age” labs, and the personalized strategies that help you extend your prime years, not just your lifespan.Sandeep explains the gaps in standard panels and why markers like lipoprotein(a), ApoB, and early insulin resistance can quietly raise cardiovascular risk for decades. He shares a practical framework for advanced therapies—rapamycin, peptides, red light, hyperbaric oxygen—rooted in evidence, safety, access, and intent, with explicit stop criteria to avoid blind experimentation. We talk through what it takes to turn vague advice into precise action: strength training as a glucose sink, protein targets, VO2 max, and sleep protocols tailored to your biology and lifestyle.We also explore the evolutionary case for a longer, more productive middle life. Wisdom tends to peak in the 50s and 60s, exactly when chronic disease often accelerates. With the right diagnostics, coaching, and accountability, it's possible to keep the energy of a 30-year-old while preserving the judgment of a seasoned leader. From there, we shift to AI's growing role in medicine: clinical copilots that surface patterns, agentic systems that handle routine care, and how empathy at scale could emerge alongside human guidance for high-stakes decisions.If you're ready to manage health with the same rigor as your wealth, this conversation offers a roadmap: better measurement, longer conversations, smarter tools, and a clear strategy that compounds over time. Subscribe, share with a friend, and tell us—what metric will you start tracking this week?https://www.velocityhealthclinic.com/Continue this conversation on SubStack: https://robertlufkinmd.substack.com Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: https://www.facebook.com/robertlufkinmd Blu...

Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠In today's episode, I'm finally circling back to one of my favorite research compounds that I don't talk about nearly enough: Cardarine (GW501516). I've used it for years in a cycled on, cycled off way, because when it works, it really works. The two big reasons people care about Cardarine are simple. Endurance and lipids.I break down why endurance athletes love it, why it makes cardio feel almost effortless for me within a week or two, and why it's not “a stimulant fat burner,” but can still absolutely support a fat loss phase when your training and diet are dialed in. Then we get into the science. I walk you through the background, how it was developed as an “exercise in a pill,” and the human trial data showing improvements in HDL, triglycerides, ApoB, liver fat, and insulin markers.And yes, we address the elephant in the room: the rodent cancer findings, the lack of long-term human data, and how I personally think about risk, dosing, and cycling. I'm not here to tell you what to do. I'm here to give you the data, how I interpret it, and let you make an informed decision.Also, at the end, I tease another compound you may want me to cover next: GW0742.

When Dave Feldman first walked into a LowCarbUSA® event in 2016 carrying a laptop full of lab results, few people could have predicted where that moment would lead.  "I'm approaching everyone with my computer," Feldman recalls, "because I'm doing these self-experiments—getting blood work—and I'm trying to figure out why my cholesterol numbers were doing what they were doing."  What started as a personal puzzle became The Cholesterol Code, a global research effort, a nonprofit scientific foundation, and now a forthcoming documentary film. In this episode of the LowCarbUSA Podcast, host Doug Reynolds sits down with Feldman to trace that journey—and to explain why the next chapter will take center stage at the Symposium for Metabolic Health in Boca Raton, January 23–25, 2026 The Question That Wouldn't Go Away Dave's original question was deceptively simple: Why do some metabolically healthy, lean people see their LDL cholesterol rise dramatically on a ketogenic diet?  Over time, he noticed a consistent pattern. These individuals didn't just have high LDL—they also tended to have high HDL, low triglycerides, and excellent metabolic health. In 2017, he coined a name for this group: Lean Mass Hyper-Responders (LMHRs). But identifying a pattern wasn't enough.  "Even if the lipid energy model proves correct," Dave explains, "does that mean having higher LDL on a ketogenic diet carries higher cardiovascular risk?"  Answering that question required something far more difficult than a blog post or a hypothesis: a prospective imaging study. Building a Study When No One Will Fund One Dave spent years trying—and failing—to convince established institutions to study this population.  "There's not a lot of funding to study metabolically healthy people with sky-high LDL," he says dryly. "The interest is usually in people who already have multiple cardiovascular risk factors—which confounds everything."  So in 2019, he made a radical decision. He founded the Citizen Science Foundation, a public charity created for a single purpose: to fund independent research, with no money going to salaries or overhead.  "We raised $200,000,"Dave says, "and paid a research center to do the study."  By late 2021, recruitment was underway. One hundred lean, metabolically healthy ketogenic individuals underwent coronary CT angiography (CTA) scans to assess plaque in their coronary arteries, with follow-up scans roughly one year later. What the Data Actually Showed The early findings were striking.  When Dave's cohort was matched against participants from the Miami Heart Study, there was no statistically significant difference in coronary plaque, despite Dave's group having LDL levels less than twice as high.  "In fact," he notes, "our group trended toward lower plaque." But the most important finding emerged as more analyses were completed:  "There was no association between ApoB or LDL and plaque progression," Dave says. "Whatever your LDL level was, it did not correspond with how plaque developed."  What did matter? Baseline plaque. "Whether you're low-carb or not," he explains, "the more plaque you have at baseline, the more likely you are to see progression. That's consistent with the existing literature." When One Dataset Didn't Make Sense Then came the controversy.  An AI-based quantitative analysis from a company called Cleerly showed plaque progression that appeared inconsistent—not only with Dave's other data, but with decades of prior research.  "All of the scans showed progression," he says. "No regression. Not even noise."  For an engineer, that raised immediate red flags.  "If a bathroom scale is off by a quarter pound," Dave explains, "you expect wobble.  Below the noise floor, measurements go up and down.  But this dataset showed only one direction." Later, when Dave gained access to the anonymized data, he identified multiple anomalies and requested a blinded quality-control reanalysis.  That request was declined.  "I don't assume wrongdoing," he emphasizes. "But when something looks implausible, the response should be course correction."  Instead, he sought independent confirmation.  A second AI company, HeartFlow, conducted a fully blinded analysis—and its results aligned with every other analysis except Cleerly's.  "Three out of four analyses agree," he says. "Cleerly is the outlier." Why This Matters Beyond One Study The implications extend far beyond a single dataset.  Dave believes this episode exposes a deeper issue in nutrition and cardiovascular science: how dominant theories shape interpretation.  "The lipid hypothesis has a gravitational pull," he says. "It affects what people expect to see—and what they question."  As I put it, Dave has repeatedly taken the LowCarbUSA stage to announce findings that challenge assumptions—and each time, the conversation moves forward.  "If we want better answers," Dave says, "we have to do better science." The Documentary—and What Comes Next All of this has reshaped his upcoming documentary, The Cholesterol Code. Originally slated for release last year, the film has been expanded to include the scientific and human story behind these findings.  "We couldn't release it without covering what happened," he explains. "It's part of the truth."  For the first time anywhere, the official trailer for the film will be shown at the LowCarbUSA Symposium in Boca, immediately following Dave's talk.  Attendees will also be invited to help bring the film to live screenings around the world.  "The world premiere of the trailer will be at your conference," Dave told me.  "That alone is worth coming for." Why You'll Want to Be There One full day of the Boca symposium is dedicated to cardiovascular health, and Dave is one of the central voices shaping that conversation. Whether you attend in person or via live stream, this is a rare opportunity to engage directly with research that is still unfolding—and with the scientist who helped drive it. As Dave puts it: "The work just needs to get done,  and in Boca, it will." Learn more and reserve your in-person or virtual seat for the Boca Symposium for Metabolic Health (January 23–25, 2026)

The guys kick things off with some classic pre-show chaos (storms, Starlink, “Wicked” talk, hay and horses) before shifting into a real conversation about health and fitness in the fire service. Freddy frames it as a “new year” topic—less about resolutions and more about lifestyle consistency—and Matt shares his on-duty heart attack story as a reminder that being “in shape” doesn't automatically equal being protected. They dig into nutrition habits, added sugar, energy drinks, sleep, accountability apps, and the idea that the goal isn't a number on the scale—it's being capable on the worst call of your career.Key Topics & MomentsWeather, Starlink, and Farm LifeWind gusts, Starlink shifting in the yard, and the dream of stable internet for streaming youth sports.Doug's day includes hay pickup and a farrier visit (hoof care)—Matt learns a new word.Quick ShoutoutHappy Birthday to “GG” (the outro celebrity) — the crew encourages listeners to comment birthday wishes.Patreon UpdatesThe crew thanks new and ongoing Patreon supporters and starts a “virtual turnout drill” segment:Subscriber spotlight questions like sunrise vs sunset, favorite sandwich, and bucket list.Merch store is still live, with the tease that Patreon members may get exclusive items.SponsorsUnkie's SeasoningTom / The Burnbox (including mention of their latest box and the “calendar”)Main Topic — Fitness, Diet, and Being ReadyFreddy sets the tone: our job isn't compatible with “fitness rollercoasters.” Staying ready matters because you never know which run will test you.Matt's On-Duty Heart Attack (Oct 18, 2022)Matt shares he had a heart attack on duty with no warning signs, despite being active and in good shape.He believes his fitness level helped him survive and recover.He talks about how it changed his mindset around diet, sugar, lifestyle, and annual health checkups.He mentions deeper cholesterol metrics like ApoB and Lp(a) and encourages listeners to talk with their cardiologist—especially with family history.The “Skinny but Unhealthy” TrapMatt describes being the “fattest skinny guy you ever met” (lots of sugar, sweets, and junk).Discussion of insulin resistance as something worth learning about and paying attention to.Freddy's Reset: Sleep, Energy Drinks, Added SugarFreddy shares his own weight swings and what derailed him: school schedules, stress, poor sleep, energy drinks.He's rebuilding with:30 minutes of daily movementZone 2 cardioCutting energy drinks and sodaReducing added sugarsUsing protein powder in coffee as a “mocha” hackDaily pushups + squats challenge (and the struggle of wanting instant results)Doug's Take: Whole Foods > Processed FoodsDoug leans into the “back to basics” approach:More whole foods, fewer lab-made processed foodsWater over sodaBlack coffee and cutting sugar where possibleHe gives a nod to Megan at RescueRD as a resource for nutrition guidance (and suggests having her back on).Apps & Tools MentionedBevel (Freddy): fitness tracking, calories/macros, accountabilityMyFitnessPal (Freddy): previous trackerYuka (Matt): barcode scanner that rates foods and highlights additives/ingredientsEncouragement to take advantage of wellness programs: labs, ECG, treadmill, etc.Snail Mail HighlightsListener Zach shares his 2026 word(s): Seek and Trust (faith, academy prep, baby #3, trusting the process).Colt shares appreciation for the ICS conversation and downloads What3Words after the episode.Quotes to Pull for Clips“This job isn't compatible with rollercoasters. You've gotta stay ready.”“Make it a lifestyle. If you stop, you feel off.”“I was the fattest skinny guy you ever met.”“If you've got family history—get a cardiologist. Once a year.”“You were treating the monitor, not the patient.”Call to ActionWhat lifestyle change are you making in 2026?Not a “resolution”—a real, achievable shift that makes you better for your department, your family, and yourself.Drop yours in the comments.

This week, Brent speaks with his personal physician, Dr. Todd Dorfman, for an update on his own health journey. Using Brent as a real-world case study, they walk through the discovery of an anomalous coronary artery, the risks and benefits of advanced cardiac diagnostics, and why more testing isn't always better. The conversation then shifts to prevention. Dr. Dorfman shares how he thinks about cholesterol, ApoB, Alzheimer's risk, statins, PCSK9 inhibitors, GLP-1 drugs, and other emerging therapies when you don't have disease but want to stay ahead of it. As always, Dr. Dorfman is a wonderful guest. Hope you enjoy.

Go to my sponsor https://trylco.com/liveleanheart and use code LiveLeanHeart to get 20% off the Comprehensive Heart Health and other select tests. Get the insights you need to live a healthier life. Heart disease is the #1 cause of death, and most people don't realize their risk is building silently for decades, even if their cholesterol test looks “normal.” In this episode of Live Lean TV, I break down why your standard cholesterol panel is missing the most important heart disease markers, and what Dr. Peter Attia actually recommends tracking for long-term cardiovascular health and longevity. According to Dr. Peter Attia, your total cholesterol number is only slightly more relevant to heart disease risk than your eye color. Instead, the real predictors are ApoB and Lp(a), two blood markers most people never test. ► Free 7 Day Trial To My Workout App: https://www.liveleantv.com ► Live Lean Body Quiz: https://www.liveleantv.com/quiz ► Free 7 Day Meal Plan And Recipes: https://www.liveleantv.com/free-stuff ⏱️ Table of Contents 00:00 Intro 00:59 Why You Need To Be Aware Of Cardiovascular Disease In Your 30's and 40's 01:32 ApoB: Your Cholesterol Test Is Missing This Heart Disease Marker 02:16 Why Lp(a) Testing Is Important For Cardiovascular Disease Risk 04:31 The Truth About Dietary Cholesterol And Heart Disease 05:53 HDL vs LDL Cholesterol Levels: What's The Difference In this video, you'll learn: ► Why heart disease risk starts building in your 30s and 40s ► What ApoB is and why it matters more than LDL cholesterol ► Why Lp(a) is a genetic risk factor you should test at least once ► The truth about dietary cholesterol, saturated fat, and heart disease ► HDL vs LDL explained in simple terms ► Why standard cholesterol tests can give a false sense of security ► The exact blood markers I personally track for heart health and longevity Subscribe Here! http://bit.ly/SubLiveLeanTV Check Out Our Top Videos! http://bit.ly/LiveLeanTVTopVideos Read the blog here: https://www.liveleantv.com/blog Listen to the podcast here: https://www.liveleantv.com/podcast WANT MORE DAILY TIPS ON HOW TO LIVE LEAN?: ► INSTAGRAM: http://www.instagram.com/bradgouthro ► INSTAGRAM: http://www.instagram.com/JessicaGouthroFitness ► INSTAGRAM: http://www.instagram.com/LiveLeanTV ► SNAPCHAT: https://www.snapchat.com/add/bradgouthro ► FACEBOOK: https://www.facebook.com/LiveLeanTV ► TWITTER: https://www.twitter.com/bradgouthro ► TWITTER: https://www.twitter.com/LiveLeanTV ► TIK-TOK: https://www.tiktok.com/@bradgouthro ► TIK-TOK: https://www.tiktok.com/@liveleantv #cholesterol #hearthealth #LiveLeanTV About Live Lean TV: Welcome to Live Lean TV. The online fitness and nutrition show, hosted by Brad and Jessica Gouthro, teaching you how to LIVE THE LEAN LIFESTYLE 365 days a year. Watch hundreds of fat blasting & muscle building workouts, easy and delicious recipes, as well as fitness and nutrition tips to get you your dream body (and maintain it 365 days a year). Make sure you click the SUBSCRIBE button for new fitness and nutrition episodes every week! Business Enquiries: info@LiveLeanTV.com Why Your Cholesterol Test Is Lying to You (ApoB, Lp(a), & Heart Disease Explained) https://youtu.be/bmALZ2tKGBA Live Lean TV https://www.youtube.com/LiveLeanTV

What if the most powerful health checkup you ever had happened at your kitchen table, not a clinic? We sit down with Dr. Natasha Milinkovic, a UK physician who moved from the front lines of vascular surgery and emergency medicine to the leading edge of preventive care, to explore how lab‑grade at‑home blood testing and intelligent coaching can change outcomes before a crisis hits.We start with the problem he saw repeatedly: people arriving late with preventable chronic disease. That urgency drives a practical roadmap for what to measure and why. You'll hear a clear breakdown of high‑value biomarkers—HbA1c for glucose trends, ApoB and the ApoB to ApoA1 ratio for cardiovascular risk, and thyroid markers for therapy tuning—and why total cholesterol alone often misleads. Tosh explains how accuracy is maintained through CLIA‑accredited labs and transparent methods, addressing trust in a post‑Theranos world. We also dig into biological age: how markers like hs‑CRP, HbA1c, and sex hormones push it up or down, and the specific lifestyle levers that can nudge it younger over the next 90 days.Then we open the hood on Sai, an AI longevity expert trained on a clinician‑curated knowledge base. Instead of scraping the noisy web, Sai reads your longitudinal labs, medications, and context to deliver personalized, evidence‑based guidance. Think trend detection for creeping glucose, stubborn ApoB, or hidden inflammation—and concrete next steps that you can take today. Looking ahead, Tosh shares what's next: home hardware that brings instant panels into your routine and a vision of predictive health where alerts trigger action long before symptoms do.If you want to cut through hype, track the markers that matter, and pair credible data with smart coaching, this conversation will give you the playbook. Subscribe, share with a friend who's optimizing their health, and leave a review with the one biomarker you plan to track this year.Note: I am an advisor to Siphox but I only advise those companies whose products I would use for myself and family.https://siphoxhealth.com/lufkinFASTING CHALLENGE: https://robert-lufkin.mykajabi.com/fast?ref=RLLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

Modern anxiety isn't just emotional. It's chemical — and it's being triggered and sustained by the way we're living, consuming, and overstimulating ourselves every single day. In this powerful, personal episode, Elizabeth pulls back the curtain on what's really happening when we feel anxious for "no reason" — and shares the neurochemical truth about dopamine, oxytocin, cortisol, and inflammation. If you're constantly in your head, overwhelmed, overstimulated, or one step away from panic — this conversation will shift everything. You'll also hear the exact strategy Elizabeth is using to reclaim peace and presence in her everyday life — without deleting her business, becoming a monk, or pretending life isn't loud and full.

In this episode, Ben Azadi reveals the real reason arteries clog and it's not age, genetics, or cholesterol. The true driver of heart disease is chronic inflammation and metabolic dysfunction. Ben breaks down five science-backed drinks proven in human studies to reduce arterial plaque, lower inflammation, improve insulin sensitivity, boost nitric oxide, and support long-term cardiovascular health. You'll learn how simple ingredients like pomegranate juice, high-quality coffee, raw cacao, apple cider vinegar, and turmeric can dramatically improve markers like ApoB, CRP, triglycerides, fasting insulin, and blood pressure. Ben also explains how to rotate these drinks for maximum benefit, which options are best for keto or diabetes, and how quickly you can expect to see results in your lab work. This episode empowers you with practical, natural tools your doctor likely never mentioned, helping you take control of your metabolic and heart health starting today. FREE GUIDE: 5 Vegetables You Must Avoid To Lose Weight & Belly Fat   - https://bit.ly/3L6xMo0 

In this Deep Dive episode of The Trip Lab, we unpack hyperlipidemia (high cholesterol) beyond the oversimplified “LDL bad, HDL good” narrative. We also take a clear-eyed look at the most common concerns people have about statins, what the evidence actually shows, and where these medications fit—and don't fit—within a thoughtful, individualized approach to cardiovascular risk.From there, we explore integrative strategies for managing elevated cholesterol and why, for many patients, lifestyle, metabolic health, and inflammation-targeted interventions may be more effective than medications alone.In this episode, we discuss:Why cholesterol is biologically essential and not inherently pathologicalThe limitations of relying on LDL alone to assess cardiovascular riskHow inflammation, insulin resistance, genetics, hormones, and lifestyle influence lipid metabolismWhen elevated cholesterol truly signals disease—and when it may reflect a compensatory or adaptive responseThe role of advanced markers such as ApoB, Lp(a), hsCRP and CAC scoresWhy risk stratification—not fear-based medicine—should guide clinical decision-makingWhat statins can (and cannot do) and we break down the concerns people have with themWhy integrative approaches (nutrition, exercise, herbal options and mind-body medicine) truly treat the root cause of diseaseThis episode is for clinicians, patients, and anyone looking to move beyond simplistic cholesterol narratives toward a more nuanced, evidence-based understanding of cardiovascular health.

Welcome to part two of our Best of 2025 series - the moments that changed how our listeners think about their health and what they do on a day-to-day basis. In this episode, we delve into simple questions with profound impact. Is it safe to experiment with your own health? Does cheese really cause bad dreams? Why do some breakfasts leave you tired and hungry, while others don't?  If you're looking for practical, science-led ideas you can take into the year ahead, this episode brings together the insights listeners found most useful, surprising, and worth returning to. Unwrap the truth about your food

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter tackles a wide-ranging set of listener questions spanning lifespan interventions, exercise, cardiovascular risk reduction, time-restricted eating, blood pressure management, hormone therapy, diagnostics, and more. Peter reveals the single most important lever for extending healthspan and lifespan, and explains how he motivates midlife patients using the Centenarian Decathlon framework. He discusses the importance of addressing high apoB and cholesterol even in metabolically healthy individuals with calcium scores of zero, how to manage high blood pressure, and how to accurately evaluate metabolic health beyond HbA1c. Additional topics include time-restricted eating, practical considerations around ultra-processed foods, nuanced approaches to HRT for women and TRT for men, and why early and expanded screening for chronic disease—colonoscopy, PSA, coronary imaging, low-dose CT—can be lifesaving. He also offers insights into treating prediabetes, crafting exercise programs for those short on time, and safely incorporating high-intensity training in older adults. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #78 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Introducing a wide-ranging AMA: practical perspectives on lifespan interventions, metabolic health, diet, hormones, diagnostics, and more [2:45]; Why exercise is the most powerful single intervention for lifespan and healthspan [4:15]; How Peter motivates midlife patients to prioritize exercise [6:00]; Why lifespan and healthspan should not be treated as competing priorities and how choosing sustainable interventions benefits both [9:30]; Why high apoB deserves treatment even in a metabolically healthy patient with a CAC score of zero [14:00]; Managing hypertension: ideal targets for blood pressure, lifestyle levers, and why early pharmacology matters [18:15]; Assessing metabolic health beyond HbA1c: fasting insulin, triglycerides, lactate, zone 2, and more [23:30]; How to avoid common self-sabotaging patterns by choosing sustainable habits over extreme health interventions [26:00]; Time-restricted eating: minimal effect beyond calorie control, implications for protein intake, and practical considerations for implementing it [28:00]; Ultra-processed foods: definitions, real-world risks, and practical guidelines for smarter consumption [30:30]; How women should prepare for menopause and think about hormone replacement therapy: early planning, symptom awareness, and guidance on HRT [36:45]; Testosterone replacement for aging men: indications, benefits, and safe clinical management [39:45]; Why Peter recommends earlier and more aggressive screening tests than guidelines suggest: colonoscopies, coronary imaging, PSA, Lp(a), and low-dose CT scans, and more [43:30]; Full-body MRI screening: benefits, limitations, potential false positives, and the importance of physician oversight [47:15]; Prediabetes: individualized treatment strategies using tailored combinations of nutrition, sleep, and training interventions [51:00]; Time-efficient training plans for people with only 30 minutes per day to exercise [53:00]; How to safely introduce high-intensity exercise for older adults [55:00]; Timed dead hangs and ripping phone books: a playful look at Peter's early attempts to impress his wife [57:15]; Peter's carve out: The Four Kings documentary about a golden era of boxing [1:01:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Master cardiovascular disease prevention! Learn how to apply the new PREVENT risk calculator, use the CPR framework for risk reclassification, and interpret ApoB and Lp(a) in modern lipid management. We're joined by Dr. Laurence Sperling to break down what's new in ASCVD risk assessment and prevention. Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments Intro Case 1 from Kashlak  Risk assessment framework ApoB and Non-HDL cholesterol Lipoprotein(a) and its importance The PREVENT risk score and its implications Statins and other lipid lowering therapies The role of diet and lifestyle in lipid management Case 2 from Kashlak Familial Hypercholesterolemia diagnosis and management Key takeaways Outro Credits Producer, Writer, Shownotes, Infographic, and Cover art: Ben Furman, MPH  Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Leah Witt, MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Laurence Sperling, MD  Disclosures Dr. Sperling reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures. Sponsor: Bucksbaum-Siegler Institute If you want to learn more about what the Bucksbaum-Siegler Institute is doing and to nominate someone for the Clinical Excellence Award—you can check them out today. Visit bucksbauminstitute.uchicago.edu. Sponsor: Grammarly  Sign up for FREE and experience how Grammarly can elevate your professional writing from start to finish. Visit Grammarly.com/podcast.  Sponsor: Continuing Education Company Use promo code Curb30 to get 30% off all online courses and webcast. Visit CMEmeeting.org/curbsiders to learn more. Sponsor: Freed Use code: CURB50 to get $50 off your first month when you subscribe!

I am honored to have Dr. Tom Dayspring join me again today for another AMA session. He and I have done eight podcasts before, and this is a continuation of our last Ask Me Anything episode.  Dr Dayspring is an esteemed expert on internal medicine and clinical lipidology. He is likely one of the most influential worldwide lipid experts, so I am thrilled to have him back with me to dive into various topics related to listener questions, including the impact of hormone replacement therapy on lipid changes, methods of administration, and why bioidentical hormone replacement therapy is preferable for managing both menopausal symptoms and lipid health. We discuss medications, including PCSK9 inhibitors and GLP-1s, as well as intermittent fasting, lipids, and cardiovascular disease risk. We also examine how heart disease develops gradually, over time, the impact of stress and lifestyle, and Dr. Dayspring shares the labs he recommends beyond traditional lipids, ApoB, and LpA. In our discussion, Dr. Dayspring noted that he was not in a position to speak about GLP-1 therapies or microdosing. Since I received many questions from listeners on those topics, I will host a future solo AMA to address some of their concerns. Today's conversation with Dr. Tom Dayspring is truly invaluable, and I trust you will walk away with valuable insights you can share with your healthcare providers. We created a PDF - cynthiathurlow.com/lipids -  specifically for listeners that outlines key labs to discuss with your providers and questions to ask them to help you advocate for your own health and your family members' health. IN THIS EPISODE, YOU WILL LEARN: Why being physically fit does not always eliminate the risk of heart problems arising How ApoB and cholesterol contribute to heart disease over decades Why the early testing of risk factors is essential How chronic stress increases the risk of heart disease  How high cortisol affects insulin sensitivity and glucose regulation How stress impacts endothelial and nitric oxide function The link between low Omega-3 levels and heart problems How insulin resistance degrades heart health How high homocysteine levels can impair endothelial function and contribute to cardiovascular problems Connect with Cynthia Thurlow   Follow on⁠ X⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia's⁠ website⁠ Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community ⁠(The Midlife Pause/Cynthia Thurlow⁠)⁠ ⁠ Cynthia's⁠ Menopause Gut Book⁠ is on presale now! Cynthia's⁠ Intermittent Fasting Transformation⁠ Book ⁠The Midlife Pause supplement line⁠ Connect with Dr. Thomas Dayspring On X (@DrLipid) On LinkedIn

In this episode, Ben Azadi breaks down five science-backed metabolic drinks that naturally reduce arterial plaque, boost nitric oxide, lower inflammation, and support metabolic health — without medications or side effects. You'll learn: • Why arterial inflammation — not cholesterol — is the real silent killer• How pomegranate juice reversed arterial plaque by 30% in human studies• The surprising cardiovascular benefits of high-quality coffee with butter, olive oil, and salt• Why raw cacao improves arterial flexibility by up to 400% (Harvard study)• How apple cider vinegar and cinnamon lower fasting glucose, HbA1c, and triglycerides• The anti-inflammatory power of turmeric + black pepper and how it calms the arteries Ben also explains:• Which drink is best for diabetics• How to rotate the drinks weekly for maximum benefit• What markers to test before and after 30 days to measure progress (ApoB, CRP, fasting insulin, triglycerides, HDL, CAC score, and more) Plus, he shares a free guide revealing the five vegetables silently inflaming your gut and slowing your metabolism — and what to eat instead. A simple daily cup could dramatically upgrade your cardiovascular and metabolic health. FREE GUIDE: 5 Vegetables You Must Avoid To Lose Weight & Belly Fat - https://bit.ly/48CIprn

Most people assume that normal cholesterol means a healthy heart, but that isn't always the case...     On today's show, we dive into why Apolipoprotein B (ApoB) is one of the most important yet overlooked markers for assessing true cardiovascular risk.     You'll learn why ApoB can reveal hidden plaque formation even when LDL appears normal, the ideal range to aim for, and why inflammation and metabolic health often matter more than total cholesterol alone.     We'll also explore the deeper factors that influence heart health, including insulin resistance, thyroid function, gut permeability, hormonal changes, diet, stress, and sleep.      Join me on today's Cabral Concept 3581 to discover what your cholesterol panel may be missing and how to take a more accurate, proactive approach to protecting your heart.     Enjoy the show!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3581 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

“VO2 max is the best predictor of lifespan,” says Peter Attia, M.D. Peter Attia, M.D., physician, founder of Early Medical, and expert in the applied science of longevity, joins us today to break down the key levers for extending both lifespan and healthspan—from how to train for a higher VO2 max to the biomarkers that truly predict long-term health. - The most powerful habit for longevity (~6:15) - VO2 max (~8:55) - How to increase your VO2 max (~10:08) - Heart rate vs. perceived exertion (~12:35) - Attia's strength training routine (~15:20) - 2 exercises Attia stopped doing (17:00) - Diminishing returns in terms of exercise (~19:55) - His take on wearables (~21:25) - Cardiovascular disease markers (~23:38) - Lowering ApoB (~25:35) - Pharmaceutical interventions for LDL & ApoB (~27:50) - Neuroinflammation markers (~37:25) - Perspectives on statins (~40:45) - The role of nutrition (~42:50) - Potential benefits of GLP-1s (~45:00) - Peptides (~47:50) - The power of exercise (~51:00) Referenced in the episode:  - Follow Attia on Instagram (@peterattiamd) - Listen to his podcast, The Peter Attia Drive  - Check out his website (https://peterattiamd.com/)  - Pick up his book, Outlive: The Science of Art & Longevity  - Take his class on MasterClass (https://www.masterclass.com/series/science-for-a-longer-better-life) - Watch the trailer for his class on MasterClass (youtube.com/watch?v=f_Mz095swls&feature=youtu.be)   We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices