Podcasts about hdl

Let’s talk about testosterone testing and other important blood tests you can track for your overall health, wellness, vitality, and longevity. I recorded this show on the occasion of my first visit to the blood lab after signing up for Vitals Vault’s premium program, and I talk about some of my favorite markers while pedaling home from the lab. I focus a lot on testosterone because I believe it’s a great proxy for overall wellness, vitality, recovery, and resilience to stress. I share my own numbers, which have ranged from 562 to 1,004, and explain why I’m so intent on keeping testosterone levels high as I age. I also get into the roughly 1% annual decline in average male testosterone levels since the 1980s, vitamin D and the widespread fear of the sun, why looking beyond LDL can give you a better picture of your lipid panel, and the lifestyle practices that can help optimize testosterone—from sleep and diet to avoiding chronic cardio, lifting heavy things, sprinting once in a while, and even maintaining a winning relationship. TIMESTAMPS: Testosterone testing is the best proxy for your overall state of wellness, vitality, and recovery or resilience to stress. [00:51] Brad checks his testosterone level frequently because it is his way of monitoring the stress impact from his training. [5:41] Triglycerides to HDL ratio is a premier indicator of your heart disease risk factor. It is much better than looking at total LDL cholesterol. [06:42] In 2017 they lowered the ideal level of testosterone due to the widespread decline of testosterone among males around the world. [09:02] If you are not optimizing your sleep, including down and rest time, you cannot reduce your stress. [12:13] Get the junk out of your diet. If you are in that chronic cardio pattern in your exercise, you may be tanking your testosterone. [12:37] If there is arguing and other dysfunctional patterns in your relationship, it will tank your testosterone as well as shorten your lifespan. [13:34] Vitamin D comes from sun exposure more than from your diet or pills. [14:30] LINKS: Brad Kearns.com BradNutrition.com B.rad Whey Protein Superfuel - The Best Protein on The Planet! B.rad Superdrink – Hydrates 28% Faster than Water—Creatine-Charged Hydration for Next-Level Power, Focus, and Recovery NEW: B.rad Real Rad Gummies - Creatine + Nootropics for Focus, Motivation, Performance, and Recovery! Brad’s Shopping Page BornToWalkBook.com B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes Vitals Vault The Vitamin D. Solution We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. Seriously, I won’t promote anything that I don't absolutely love and use in daily life: Recover Faster: B.rad Superfuel helps with fat loss, longevity, immune function and athletic performance with a potent combo of grassfed whey protein and creatine. A five-star bestseller on Amazon, or order direct and save! Get 20% OFF your first order with code BRAD20 Strengthen Your Feet: Peluva five-toe minimalist shoes naturally strengthen and realign your feet to perform better, relieve pain, and achieve full functionality. Use code BRADPODCAST for 10% off Online Education: Immersive learning to transform your diet in 21 days, endurance train the right way, prepare Paleo meals for the whole week, get started the right way the therapeutic cold exposure, and custom-design a morning movement routine. Clean Your Indoor Air!: The Jaspr Air Scrubber is an ultra high-performance, automatic-sensor unit that will address the often-disregarded health concern of indoor air quality. Save $200 on your unit with code BRAD Explore B.rad Nutrition, online courses, and my favorite gear at: BradKearns.com/Shop Enjoying the podcast?Please leave a quick review on Apple Podcasts—it helps more people discover the show. Thanks for your support! #bradpodcastSee omnystudio.com/listener for privacy information.

After performing thousands of open-heart surgeries, Dr. Philip Ovadia recognized that the vast majority were preventable…if his patients had improved their metabolic health in the first place. In this episode, Dr. Chris Motley sat down with heart surgeon, author and podcaster Dr. Philip Ovadia to learn about the underrated relationship between insulin resistance and heart disease, and what you need to know to arm yourself at home and in the doctor's office.  If heart disease has been the number one killer for so long, isn't it possible that we're tackling it the wrong way? Dr. Ovadia's belief is that our emphasis on cholesterol has done us a disservice when it comes to heart health.  If you have a family history of heart issues, or a heart condition yourself, learn how Dr. Ovadia believes you can stay off his operating table.  In this episode you will learn: Why cholesterol and LDLs are not the real enemy of the heart and how sugar is the real culprit when it comes to heart disease.  Why 70 years of cholesterol-focused medicine hasn't reduced heart disease — and what the data actually shows about LDL's role in cardiac events The Craft Test: how Dr. Joseph Craft discovered in the 1970s that 95% of heart disease patients had insulin resistance — compared to only 50% with elevated cholesterol Why your fasting insulin level is the most important number most doctors never order — and how to get it tested for around $10 What exactly to ask your doctor about insulin resistance, and signs and symptoms for it: waist circumference, blood pressure, fasting glucose, HDL cholesterol and triglycerides. How stress plays a role in heart conditions, and how emotional support can make a difference in patients' outcomes. Why statin drugs can be problematic, in that they hide the symptom rather than attacking the root of the problem.  The single question to ask your doctor that will immediately reveal whether they understand metabolic heart disease: "Am I insulin resistant?" Why skin tags, belly fat, rounded face, low energy and high blood pressure are early warning signs of insulin resistance — years before chest pain or shortness of breath appear Dr. Ovadia's recommendations for diet and lifestyle changes to keep you off the operating table: processed food needs to go, and we must move more. If you have a desk-job, try a standing desk or simply get up and move around once an hour.  Meat is medicine. Dr. Ovadia advocates for the nutritional density of meat, yes, even red meat, and suggests that a low-fat diet has not prevented heart disease as promised.  Vitamin K2 and CoQ10 feed the mitochondria our hearts need for energy.  The effects of common viruses like strep on the heart valves. What role genetics plays in heart disease versus habits.  Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. ------  Follow Doctor Motley! Instagram Facebook Website Follow Dr. Philip Ovadia https://www.instagram.com/ifixhearts/ https://ifixhearts.com/team/ https://www.youtube.com/@IFixHearts Buy his books: https://ovadiahearthealth.com/books/ ------  *Head to www.beamminerals.com/DRMOTLEY and enter code DRMOTLEY for 20% off your mineral replenishment order. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here https://www.doctormotley.com/15

HEALTH NEWS   Chamomile Rinse Matches Chlorhexidine in Reducing Plaque and Gum Inflammation, Trial Finds A few minutes of sprinting could make a bigger impact than 90 minutes of moderate running Ultra-processed foods linked to higher prostate cancer risk in men Cinnamon Supplementation Associated With Lower Blood Sugar and Cholesterol in Review of 21 Meta-Analyses Healthy lifestyle cuts hearing impairment risk by 14%, metabolism is key driver     Chamomile Rinse Matches Chlorhexidine in Reducing Plaque and Gum Inflammation, Trial Finds Western University of Arad (Romania), August 12 2026  (Natural News)   A chamomile herbal rinse reduced plaque buildup and gum inflammation on par with chlorhexidine. Researchers enrolled 175 healthy adults and divided them into five groups: chamomile, sage, ginger, placebo, or chlorhexidine rinses, the report stated.   Over twelve weeks, researchers tracked plaque accumulation and gingival inflammation using standardized dental indexes. Participants rinsed daily with their assigned solution, and measurements were recorded at intervals across the study period.    Chamomile's effect relies on plant compounds including apigenin and chamazulene, which act through anti-inflammatory pathways, while chlorhexidine works through strong antimicrobial action, researchers said. Chamomile flower material contains acylated derivatives of apigenin 7-O-glucoside. Every active rinse, including chamomile, produced significant reductions compared to placebo. Chamomile performed statistically on par with chlorhexidine, the rinse most dentists reach for first.  Chlorhexidine is a prescription-strength antiseptic that dentists consider the gold standard for controlling plaque. Long-term chlorhexidine use commonly causes tooth staining, taste changes, and irritation of soft tissue inside the mouth.   A few minutes of sprinting could make a bigger impact than 90 minutes of moderate running Rockefeller University, August 13 2026 (Eurekalert) Three minutes of sprinting can do something that 90 minutes of moderate exercise apparently cannot: dramatically reshape the molecular contents of the bloodstream. Rockefeller researchers comparing different intensities of exercise found that six sets of 30-second, all-out sprints altered nearly a quarter of the proteins measured immediately afterward. Moderate, continuous cycling for 90 minutes altered fewer than one-quarter of one percent. And while moderate running on a treadmill changed more proteins than cycling, it still altered far fewer than a quick sprint. Sprinting triggered changes in more than 200 metabolites. It also caused an immediate surge of proteins involved in blood-vessel growth, tissue remodeling, and hormonal signaling. Some of these proteins appear to enter the bloodstream through an expedited cell signaling process known as ectodomain shedding—rather than being newly made and secreted, portions of proteins already sitting on the cell surface were cleaved off and rapidly released into circulation. The researchers also found that human fat cells exposed to blood collected after sprinting underwent extensive changes in gene activity, shifting how the cells process fuel, respond to hormones, and sense nutrient availability. Not so with moderate exercise which produced a more modest response. It was not until three hours after completing that exercise that a meaningful wave of the fatty acids and liver-derived proteins that typically appear in response to the demands of endurance exercise were found in the bloodstream.    Ultra-processed foods linked to higher prostate cancer risk in men Florida Atlantic University, August 12 2026 (News-Medical)     Ultra-processed foods (UPFs) account for nearly 60% of adults' and 70% of children's energy intake in the United States.  New research from Florida Atlantic University provides evidence that men with higher consumption of UPFs have increased risks of prostate cancer.  Published in The American Journal of Medicine, the study provides analyses from a large and nationally representative data from 17,024 U.S. men ages 18 and older. Researchers used two 24-hour dietary recalls to calculate the percentage of daily calories participants consumed from UPFs.  Men in the three higher-consumption groups of UPFs had a 29% greater risk of prostate cancer, while those in the two highest-consumption groups had a 30% greater risk, compared to those in the lowest consumption group. After adjustments, the increased risk remained significant, ranging from 24% to 31%. Men with the highest UPF intake alone had a possible 34% higher risk, although the finding did not reach statistical significance, potentially reflecting the smaller number of prostate cancer cases in that group.     Cinnamon Supplementation Associated With Lower Blood Sugar and Cholesterol in Review of 21 Meta-Analyses Lanzhou University Second Clinical Medical College (China), August 11 2026 (Natural News) A pooled analysis of 21 meta-analyses, including 139 placebo-controlled comparisons, found cinnamon supplementation associated with lower HbA1c, total cholesterol, LDL cholesterol, and blood pressure, according to a report published in Frontiers in Nutrition. The report stated that the strongest effects occurred at daily amounts above 1.5 grams, or roughly three-quarters of a teaspoon, for periods of two months or less. Compared with placebo, cinnamon supplementation was tied to a measurable reduction in HbA1c, the blood test doctors use to track blood sugar control over the previous several months, the article stated. Total cholesterol and LDL cholesterol also declined, and blood pressure readings improved, according to the analysis. Ceylon cinnamon, sometimes labeled 'true cinnamon,' contains only trace amounts of coumarin, while Cassia cinnamon, the variety commonly found on supermarket shelves, contains higher levels, according to the article. For daily use, experts cited in the report recommend limiting Cassia cinnamon to about one teaspoon or less, with occasional larger amounts considered unlikely to cause harm.   Healthy lifestyle cuts hearing impairment risk by 14%, metabolism is key driver Fudan University (Japan), August 12 2026 (News-Medical)     Hearing impairment ranks as the third largest contributor to global disability among sensory disorders, with prevalence rising across younger and middle-aged populations alongside older adults.  The Fudan University team conducted an analysis of 441,844 UK Biobank participants aged 40 to 69 at baseline, with a median follow-up of 14.22 years. The researchers constructed a comprehensive lifestyle score spanning seven behaviors: smoking status, alcohol consumption, physical activity, sleep duration, sedentary time, social engagement, and dietary supplement use. Over the study period, 20,743 incident cases of hearing impairment were documented.  Participants with an ideal lifestyle had a 14% lower risk of developing hearing impairment than those with a poor lifestyle. Among individual factors, smoking cessation offered the greatest preventive benefit, followed by reduced sedentary time; dietary supplement use showed no protective effect, and social contact frequency was not significantly associated with hearing risk. The study's core insight emerges from its quantitative mediation analysis, which revealed metabolic dysfunction as the dominant biological pathway linking lifestyle to auditory health. Metabolic biomarkers–most notably BMI and HDL-c–mediated approximately 16.5% and 14.0% of the total lifestyle–hearing association respectively. In contrast, each inflammatory marker contributed less than 6% of the effect, playing only a secondary role. 

Does lower cholesterol equal less plaque? The answer may surprise you. On this episode of Vitality Radio, Jared explores emerging research on nattokinase, a systemic enzyme derived from fermented soybeans, and its potential role in supporting cardiovascular health. He reviews a 2017 clinical trial comparing nattokinase with a commonly prescribed statin, discusses why imaging studies of arterial plaque may offer a different perspective than cholesterol markers alone, and explains how fibrin may influence plaque structure. Jared also breaks down the importance of dosage, why many studies suggest higher amounts may produce different results than standard servings, and how systemic enzymes fit into a broader heart health strategy. As always, he encourages listeners to understand the research, ask better questions, and work with qualified healthcare professionals when making decisions about their cardiovascular health.Products:NattokinaseFibrenza Systemic EnzymesSun Nutrition Vascular Defense Systemic Enzyme & N.O. BlendVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.This podcast is produced by DrTalks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/

"It [cardiovascular disease]  becomes an issue in middle age because that's when they start looking, not because that's when it starts." —Dr. Daniel Chong Heart disease and midlife are more connected than most people — or their doctors — realize, and this episode of Essential Ingredients pulls that connection into the open. Justine Reichman sits down with naturopathic physician Dr. Daniel Chong and returning co-host Dr. Lisa Brent to unpack why cardiovascular risk quietly rises for both men and women in midlife, and why so few people are told to watch for it until it's already underway. This conversation is for anyone in perimenopause, menopause, or andropause who's been handed a cholesterol number without context, or who's simply never been told when to start paying attention. Dr. Chong breaks down lipid testing, arterial plaque, nitric oxide, and even the surprising role your dentist plays in your heart health — all in plain, usable language. By the end, you'll understand that cardiovascular disease isn't a midlife event — it's a decades-long process that just happens to get noticed in midlife, and that the actions you take starting this week can change its trajectory. Key Takeaways: Plaque development in the arteries can begin in childhood or even before birth, so family history matters far more than age when deciding when to start testing. A single elevated LDL reading isn't enough to justify a statin prescription — triglyceride-to-HDL ratios and more detailed testing give a fuller picture. Gum disease and harsh antibacterial mouthwash can disrupt oral bacteria needed to produce nitric oxide, which directly affects artery health. Dark leafy greens, berries, garlic, and onions support nitric oxide production and should be eaten daily, regardless of what else is on the plate. Movement spread throughout the day — not just a single workout — meaningfully lowers cardiovascular risk on its own. Around age 35–40 is a reasonable starting point for a fasting lipid panel if there's no strong family history pushing that number younger. Listen to the full episode for the complete breakdown of lab testing, imaging, and diet strategy Dr. Chong uses with his patients:  https://tinyurl.com/Essential-Ingredients-Podcast  Meet Daniel:  An expert in cardiovascular health, Dr. Daniel Chong is a licensed naturopathic physician with over two decades of experience. He earned his doctorate from the National University of Natural Medicine in 2000. Dr. Chong specializes in preventing and reversing cardiovascular disease using drug-free strategies, defining himself as a "nutritional angiologist." He holds advanced certifications in cardiometabolic medicine and the Bale-Doneen Method for heart attack prevention. Dr. Chong helps patients optimize arterial health through advanced risk assessment, lifestyle medicine, and nutrition at his Vital Human telehealth practice and Portland clinic.  Website Facebook  LinkedIn Instagram Meet Lisa:  Dr. Lisa Brent is a licensed naturopathic doctor and acupuncturist specializing in women's health. With a commitment to holistic and patient-centered care, she integrates primary care training with expertise in lifestyle medicine, nutrition, bioidentical hormone therapy, and gut health. Dr. Brent is dedicated to empowering her patients through education, individualized wellness strategies, and compassionate support. She is the founder of Be Well Natural Medicine, hosts educational events such as the Women's Health Symposium, and provides care both in-person and via telehealth. Website Instagram Facebook Connect with NextGen Purpose: Website Facebook Instagram LinkedIn YouTube Podcast Chapters: 00:32 The #1 Cause of Death for Women Nobody Talks About 02:14 Meet Dr. Daniel Chong: Cardiovascular Expert 04:17 Why Heart Disease Risk Rises in Midlife 06:02 When Should You Start Checking Your Cholesterol? 09:02 How Long Elevated Lipids Matter More Than the Number 11:44 The Hormone Mistake Most People Make 17:21 What to Actually Ask Your Doctor 18:42 Why One Lipid Panel Isn't Enough for a Diagnosis 24:05 The Surprising Link Between Dental Health and Heart Disease 28:37 The Diet Pattern That Actually Protects Your Heart 37:17 One Change to Make This Week   THE PRIMES  ✨ You're more capable than you have ever been, and somehow more invisible than ever. You keep handing out advice you do not take yourself. You keep saying 'after this next thing' to your own life, and the people around you have no idea because, from the outside, everything looks fine— that is exactly what The Primes was built for.

You felt fine this morning. You went to the gym, ate your usual, told yourself you were healthy. But your blood work is telling a completely different story, and by the time your body starts shouting, the damage has been years in the making. In this episode, I read Alex's full lab panel live and show him exactly where "normal" was quietly hiding a real problem. Get Ben's new book Keto Flex here → https://bit.ly/4wKG1sM What we get into: Why "in range" on your labs is not the same as healthy, and how the reference range is built on the average of an unhealthy population The markerbiohacksasic yearly panel skips: triglyceride-to-HDL ratio, LP(a), homocysteine, fasting insulin, and free testosterone How Alex felt totally fine while sitting at pre-diabetic blood sugar, a testosterone of 225, and a cardiovascular risk ratio of 8.2 The simple swaps that move the needle: killing seed oils, cutting the sugar hiding in green juices, and mastering the foundations before the fancy biohacks Remember this: If you treat your health casually, you will end up a casualty. Find All The Ben Azadi Show Sponsorship Deals → https://www.ketokamp.com/sponsorship-deals Ben's website → http://www.benazadi.com

Cholesterol has been one of the most confusing topics in the wellness world for decades. Is cholesterol actually the villain we've been told it is? What do LDL, HDL, and triglycerides really mean? And how much does the food on your plate actually affect your numbers?In this episode, Lisa breaks down the cholesterol conversation in a way that's easier to understand, from what your lipid panel is actually measuring to how nutrition, movement, stress, hormones, and everyday habits can influence your cardiovascular health.We'll also talk about how cholesterol and metabolism can change throughout different stages of life, including perimenopause and beyond, and how you can use the Healthi app to become more intentional about the quality of the foods you're eating.No fear. No food guilt. Just a conversation designed to help you feel more informed and confident about your health. ❤️

Can you lower LDL cholesterol by changing the foods you eat?   Dr. David Jenkins, the pioneering nutrition researcher behind the Portfolio Diet, joins Chuck Carroll to explain how a carefully selected combination of foods may help bring cholesterol under control.   Dr. Jenkins reveals why oats and barley may be particularly effective for lowering cholesterol, how their sticky soluble fiber interacts with bile acids, and why simply telling someone to "eat more fiber" may not be specific enough.   You'll also learn: The difference between LDL and HDL cholesterol Whether dietary cholesterol is necessary for good health How the Portfolio Diet was developed Why soy may lower LDL while replacing less healthy proteins The difference between fats from plants and animals Why nuts can be beneficial despite being high in fat and calories What extra-virgin olive oil may offer beyond unsaturated fat How plant-based eating can benefit human and planetary health Why partial dietary changes can still be meaningful How diet may be used alongside cholesterol-lowering medication   Dr. Jenkins is a professor of medicine and nutritional sciences at the University of Toronto and one of the world's leading researchers on diet, cholesterol, diabetes, plant protein, and soluble fiber.   Hear more from Dr. Jenkins at the International Conference on Nutrition in Medicine, Aug. 13–15, 2026, in Washington, D.C.  

A rash baffled 25 years of dermatologists. It disappeared in a week once Dr. Steven Zodkoy traced it to a childhood memory. Here's what that case, and the concept of a "biofilm," has to do with your migraines and your bladder. Dr. Chris Motley sits down with Dr. Steven Zodkoy, a chiropractor and applied kinesiologist who became the first in his field to pass the American College of Nutrition exam, a credential previously reserved for MDs and PhDs. Thirty-five years into practice, Dr. Zodkoy specializes in the patient conventional medicine gave up on: the migraine sufferer, the "recurring UTI" patient who never actually had a UTI, the chronic fatigue case with a normal bloodwork panel. His framework rests on one idea most doctors do not test for: the biofilm, a sticky protective layer that bacteria, viruses, mold, and parasites lay down to hide from the immune system and from treatment. Once one pathogen builds a biofilm, Zodkoy argues, it invites others in, which is why a "cured" infection so often resurfaces as something else entirely, chronic sinusitis becoming Lyme-like fatigue, a bladder infection becoming a lifetime of unexplained pelvic tightness, a resistant childhood strain becoming an adult autoimmune diagnosis.  Key Takeaways Biofilms are why a "cleared" infection keeps coming back as something else. A biofilm is the mucous-like shield a bacterium, virus, parasite, or mold colony builds to hide from the immune system and from antibiotics. Once it's there, he says, it invites other pathogens to shelter in it too, which can explain why chronic sinusitis, Lyme-linked fatigue, and mold exposure so often show up in the same patient.  Interstitial cystitis is frequently a tight-bladder problem being treated as a recurrent UTI. Dr. Zodkoy's read: stress and anxiety tighten the bladder, it never fully empties, and what's left behind gets infected, so the antibiotic treats a symptom while the muscle stays tight and the infections keep returning. His protocol adjusts the pelvic floor and pubic symphysis, then layers in biofilm-breaking supplements and emotional work.  A 25-year rash resolved after one round of Neuro-Emotional Technique tied to an age-seven memory. Every physical test on this patient, mold, yeast, parasites, heavy metals, came back clean. Emotional testing didn't.  His migraine protocol runs liver support first, nervous system second, emotional work third, in that order, on purpose. Dr. Zodkoy's 1992 theory ties migraines to a slow-functioning liver overloaded by chemical exposure, hormones, or diet. He walks us through his 8-week liver protocol, 16 weeks including autonomic nervous system support, and a 96% success rate once emotional work is added. You cannot do deep detox or trauma work on a nervous system that has nothing left. There's no point moving to detox, biofilm-clearing, or emotional release until a patient's self-rated energy crosses roughly 50 to 60 out of 100.  [00:00:00] Cold open: migraines, interstitial cystitis, chronic fatigue, and the biofilm nobody explains  [00:02:02] Origin story: "doctor, lawyer, doctor" and practicing three months before 25  [00:04:04] Why he became a nutritionist first: the autonomic nervous system as the missing piece  [00:06:08] Finding a hidden emotion: the six-minute visit versus a real history  [00:09:37] The HPA axis toolkit: DHEA, GABA, adaptogens, and a gut bacterium built for stress  [00:11:27] NET, emotion code, and generational trauma: "it doesn't have to be real, it has to be believed"  [00:14:36] The 25-year rash: a muscle test, a forgotten age seven, and a mother's confession  [00:19:04] Migraines: the 1992 liver theory, the 80/20 split, and a claimed 96% success rate  [00:23:43] Interstitial cystitis is not a UTI: the tight bladder nobody is treating [00:27:06]  Killing the biofilm: natokinase, antimicrobials, and cranial electrotherapy stimulation  [00:31:29] The sympathetic-parasympathetic seesaw, and why healing collapses without it  [00:34:59] The "oomph" scale: testing cortisol at home and in the office  [00:36:27] The protocol in order: glandulars, adaptogens, and parasympathetic support, dosed on purpose  [00:43:30] Chronic fatigue, sinus biofilms, and the "house party" that becomes Lyme, EBV, and mold  [00:47:19] Parasites in America, and the TG/HDL ratio he says predicts heart risk  [01:00:02] Closing: where to find Dr. Zodkoy, and a teed-up follow-up on the healthcare system Resources Mentioned Tools & Products Biofilm Clear: Zodkoy's stated favorite combination product for breaking down biofilms, made up of natokinase, serrapeptase, lumbrokinase, and bromelain. He describes dosing at 2000 IU for patients under 50 and up to 4000 IU for patients over 50 with abnormal bloodwork. CP2305 (referenced in audio as "PC2305"): a Lactobacillus gasseri probiotic strain studied for stress and HPA-axis effects. True Laser: a home low-level laser device Zodkoy places over the vagus nerve. Cranial electrotherapy stimulation (CES) units: clip-on-the-ear devices Zodkoy uses for anxiety, sleep, depression, and (with pads placed over the bladder) interstitial cystitis relief. Adrenal glandular products (brand examples given: Adrenal Complex from Designs for Health, Adrenal from Orthomolecular, Cortex from Thorne Research), used at a fraction of label dose, one pill in the morning only, per Zodkoy's protocol. Adaptogens referenced: ashwagandha, holy basil, rhodiola, cordyceps. • Nervous-system support referenced: DHEA, L-theanine, GABA, phosphatidylserine, adrenoglandulars. Antimicrobials referenced for biofilm-associated infections: berberine, olive leaf, oregano. Nutrients referenced for liver-support migraine protocol: B vitamins, glutathione, NAC. Concepts referenced: HPA axis (hypothalamus-pituitary-adrenal): the stress-response pathway Zodkoy targets before any other intervention. Applied kinesiology: manual muscle testing Zodkoy uses to distinguish emotional, physical, biochemical, parasitic, fungal, or toxic causes of a symptom. NET (Neuro-Emotional Technique), Emotion Code, Body Code: hands-on techniques used to locate and release stored emotional triggers. Sympathetic and parasympathetic nervous system balance: the "seesaw" framework underlying his treatment sequencing. • Triglyceride-to-HDL ratio: Zodkoy's preferred cardiovascular risk marker over total cholestero Want more of The Ancient Health Podcast? Subscribe to the YouTube channel. ------  Follow Doctor Motley! Instagram TikTok Facebook Website Follow Dr. Steven Zodkoy https://www.instagram.com/drstevenzodkoy/ ------  *You can get cell support in gummy form: Mitopure now starts at $79, when you go to timeline.com/DRMOTLEY. *Join Doctor Motley's newsletter for TCM insights and regular podcast updates https://www.doctormotley.com/ *Do you have a ton more in-depth questions for Doctor Motley? Check out his course on emotions and the body in his membership. You'll find other courses full of his expertise and clinical wisdom, plus bring all your questions to his weekly lives! To try risk-free for 15 days click here https://www.doctormotley.com/15

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Lower HDL doesn't mean worse. Esselstyn explains how inflammation flips HDL's role—and why plants still win. #HDLCholesterol #Inflammation #PlantBasedScience #HealthTalks

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Jim Otvos is a biophysical chemist who pioneered the use of nuclear magnetic resonance (NMR) spectroscopy to measure lipoprotein particles and developed the first FDA-cleared method for directly quantifying LDL particle number (LDL-P), a technology that has since expanded to provide broader insights into metabolic health, inflammation, insulin resistance, and mortality risk. In this episode, Jim recounts the unlikely story of transforming a flawed cancer test into a new way of measuring lipoproteins, explains what standard cholesterol tests can miss and why LDL-P and apoB can inform treatment decisions beyond LDL cholesterol alone, and dispels the misconception that large, "fluffy" LDL particles are benign. He also explores how NMR can reveal insulin resistance before blood sugar rises, GlycA as a marker of chronic low-grade inflammation, and the metabolic vulnerability index (MVX) as a potential measure of frailty, resilience, and mortality risk across the lifespan. Finally, Jim explains why NMR diagnostics remain underused despite the wealth of information they can extract from a single blood test. We discuss: How investigating a flawed 1986 cancer test led to the development of NMR (nuclear magnetic resonance) lipoprotein testing [3:30]; How standard lipid panels measure cholesterol and triglycerides, and why LDL cholesterol is estimated rather than directly measured [15:15]; How NMR spectroscopy measures lipoprotein particle size and concentration [20:30]; Why LDL particle number matters more than particle size, and why large, "fluffy" LDL is not benign [28:45]; Discordance between LDL cholesterol and LDL particle number: which measure better reflects cardiovascular risk? [36:30]; How metabolic syndrome and lipid-lowering treatment contribute to the discordance between LDL-C and LDL-P, and the value of particle number for managing risk [45:30]; Using the NMR-derived LP-IR score to detect insulin resistance and predict type 2 diabetes before glucose rises [51:15]; The development, commercialization, and uncertain future of the Vantera NMR Analyzer and NMR-based diagnostics [1:04:45]; The analytical efficiency of NMR testing and the data-driven development of the Metabolic Vulnerability Index (MVX) [1:16:00]; GlycA as an NMR-derived marker of systemic inflammation: its discovery, biological basis, and advantages over hs-CRP [1:25:45]; Developing the Metabolic Vulnerability Index (MVX): biomarkers of inflammation, malnutrition, muscle wasting, and mortality risk [1:34:00]; What MVX can tell us about longevity and mortality [1:44:15]; How MVX may reveal metabolic frailty and predict premature mortality decades in advance in young, healthy adults [1:50:30]; Potential applications of MVX for predicting treatment response, surgical resilience, and clinical trial outcomes, and the barriers to broader use [2:00:00]; ApoB versus LDL-P: their clinical similarities, the additional information provided by NMR, and barriers to broader adoption [2:07:30]; Interpreting the effects of the CETP inhibitor, obicetrapib, on LDL-P, apoB, and small HDL particles [2:13:00]; The future of NMR diagnostics and MVX: translating scientific potential into broader clinical use [2:20:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Lowering ApoB and non-HDL cholesterol starts with improving how your body clears cholesterol. Michelle recommends reducing saturated fat, replacing it with healthy unsaturated fats, gradually increasing soluble fibre, staying well hydrated, and supporting gut health. As oestrogen declines in perimenopause, maintaining nitric oxide production and healthy blood vessels also becomes increasingly important. KEY TAKEAWAYS Reduce saturated fat intake. Replace with omega-3-rich and other unsaturated fats. Increase fibre gradually to avoid bloating. Prioritise soluble fibre (oats, raspberries, chia seeds). Stay hydrated to support cholesterol excretion. Support nitric oxide production with foods like beets and leafy greens. Maintain gut health to support both heart health and fibre tolerance. Want to go deeper? Start here: Fresh Start Sundays Newsletter Your weekly 3-minute guide to creating the healthiest, most vibrant version of you. Each Monday, get one simple habit to boost energy, balance hormones, and enhance longevity - joined by 25,000+ women worldwide. https://angelafosterperformance.com/ The 21-Day Hormone Reset Doing everything right but still don't feel like yourself? The 21-Day Hormone Reset helps you understand your hormones, restore your energy, and start working with your body instead of against it. https://www.highperformance-health.com/ The Ultimate Guide to Creatine for Women https://academy.angelafosterperformance.com/ 10 Habits That Helped Me Reverse My Biological Age by 25 Years During Perimenopause https://academy.angelafosterperformance.com/ About Angela Foster Angela Foster is a corporate lawyer turned health and performance coach, keynote speaker, and creator of the BioSyncing® Method. She is the host of the High Performance Health Podcast, featuring over 500 conversations with world-leading experts in longevity, hormones, neuroscience, nutrition, and female performance. Angela's mission is to help one million ambitious women optimise their hormones, energy, cognitive performance, and longevity—so they never have to choose between success and their health. If you enjoyed this episode, please subscribe, leave a review, and share it with someone who would benefit from it. Follow Angela for daily health and performance tips: Instagram: @angelasfoster Facebook: @AngelaFosterPerformance

Millionen Menschen nehmen täglich Medikamente gegen zu hohes Cholesterin – und trotzdem reicht es bei vielen nicht aus. Jetzt wurde in Amerika ein neues Mittel zugelassen, das LDL, also den bösen Cholesterinwert, um bis zu 60 Prozent senken kann.In dieser Folge sprechen wir darüber, was schlechtes Cholesterin im Körper anrichtet, warum ein niedriger Wert nicht immer besser ist – und wann dieses Medikament auch bei uns zu erwarten ist.Es geht um Schaumzellen, B-Zell-Margarine und PCSK9.02:24 HDL und LDL04:30 Statin09:09 Ernährung als Hebel13:10 „Edel-Klinik“

Disclaimer: This article is for educational purposes only and is not a substitute for individualized medical advice. Talk to your own physician before making decisions about cancer screening, testing, or treatment.TL;DR* A healthy 58-year-old gets a routine full-body scan, finds a “cancer” that would never have hurt him, and ends up with permanent incontinence from unnecessary treatment. This is more common than most people realize.* Dr. H. Gilbert Welch, a Dartmouth-trained cancer epidemiologist, spent 30 years documenting overdiagnosis — the discovery of cancers that meet the technical definition but would never have caused harm. His estimate: roughly 60% of PSA-detected prostate cancers and 25% of mammography-detected breast cancers fall into this category.* The “5-year survival rate” you hear cited as proof screening saves lives is often distorted by lead-time bias — finding a cancer earlier can make survival numbers look better without adding a single day to anyone's life.* Not all screening is suspect. Colonoscopy, low-dose CT for high-risk smokers, and cervical cancer screening (Pap/HPV) have strong randomized-trial evidence behind them.* The piece conventional screening misses: metabolic health. A 2026 Nature Communications study using machine learning on UK biobank data linked insulin resistance to increased risk across at least 12 cancer types — independent of body weight — and standard checkups rarely test for it.* Want a personalized look at your own metabolic terrain? Book a Metabolic Audit Call — link in show notes, spots limited weekly.The Test That Didn't Save His LifePicture a 58-year-old man. Healthy weight, active, doesn't smoke, feels completely fine. He goes in for a routine total-body scan — the kind now available at imaging centers with no doctor's referral required. Two hours later, a radiologist flags a small spot on his prostate.Six months, two biopsies, and one surgery later, he has a diagnosis: permanent incontinence. And the cancer itself? “Clinically insignificant.” It almost certainly would never have caused him harm. He would have lived out a full life and died of something else entirely, never knowing it was there.The test didn't save his life. It changed it — for the worse.This scenario happens thousands of times a year, and it's exactly what Dr. H. Gilbert Welch — a general internist, cancer epidemiologist, and senior researcher at Brigham and Women's Hospital — spent his career warning about. His book, Should I Be Tested for Cancer?, makes a case that runs against decades of public health messaging: more testing is not automatically better testing, and early detection does not automatically mean lives saved.This article unpacks what Welch got right, where his argument leaves a gap, and what a more complete, proactive approach to cancer risk actually looks like.The Cancer Reservoir: Why Finding More Doesn't Mean Saving MoreFor decades, the operating assumption in medicine has been simple: catch cancer early, save the life. No asterisk, no nuance.Welch's research complicates that. His central idea is the cancer reservoir — the observation that most people carry small clusters of abnormal cells somewhere in their bodies right now. In the prostate, thyroid, breast, or lung. Under a microscope, these cells look like cancer. But many of them will never grow, never spread, and never threaten a life. A person could carry one for thirty years and die at 87 of heart disease, never knowing it existed.The problem is that increasingly sensitive tools — full-body scans, PSA tests, low-dose CT — are very good at finding these dormant clusters. And once something is found and labeled “cancer,” the medical system is built to treat it.Welch's numbers, drawn from randomized trial data, are striking: approximately 60% of PSA-detected prostate cancers are overdiagnosed, meaning they meet the technical definition of cancer but would never have caused symptoms or death. For mammography-detected breast cancers, the estimate is around 25% — meaning roughly one in four women treated for a screen-detected breast cancer may never have needed that treatment: the chemotherapy, the radiation, the surgery, the fear, the financial cost.This isn't an anti-medicine argument. It's a call for a conversation that rarely happens: here's the case for this test, and here's the case against it — here's what we might find that helps you, and here's what we might find that sets off a chain reaction you'll spend years managing. For most patients, that conversation never occurs.The 5-Year Survival Stat Is Misleading YouFive-year survival rates for cancer are often cited as evidence that screening works — and they sound like exactly that. But Welch shows why the number can be deceptive, and it comes down to lead-time bias.Here's the mechanism. Imagine a woman whose cancer will kill her at 65, regardless of when it's found. If screening catches it at 62, she lives three years with the diagnosis before dying at 65 — a five-year survival rate under five years. But if that same cancer isn't found until symptoms appear at 64, she lives one year with the diagnosis and dies at 65 — a five-year survival rate of zero.Same woman. Same cancer. Same date of death. But the version of her found earlier through screening appears, statistically, to have “survived longer.” Screening didn't add a single day to her life — it just moved up the start date of her diagnosis. It's the equivalent of claiming a win in a race because someone moved your starting line 200 meters ahead of everyone else's: you didn't run faster, you just started earlier. The finish line never moved.Now layer in overdiagnosis. If 1,000 people are diagnosed with cancers that would never have hurt them, and all 1,000 are alive five years later — which they would have been regardless — the survival statistics look dramatically better without a single life actually being saved. Welch's research shows that 5-year survival rates can climb while actual cancer death rates stay flat. More survivors on paper. Same number of people dying.None of this means medicine isn't making genuine progress in some cancers — colon cancer being a clear example, discussed below. It does mean that 5-year survival statistics, on their own, are not proof that a screening program is saving lives.Where the Evidence for Screening Is Actually StrongIt would be a mistake to leave this discussion thinking all screening is suspect. Welch himself is careful to draw a distinction, and there are tests with solid, randomized-trial evidence behind them.Colonoscopy for colorectal cancer is arguably the strongest case for screening that exists. It's unique because it doesn't just detect cancer — it can prevent it, by removing precancerous polyps before they ever become malignant. Colon cancer incidence and mortality have both dropped measurably in populations with high screening rates. If you're 45 or older, or have a family history, this is worth a serious conversation with your doctor.Low-dose CT for lung cancer, in high-risk individuals specifically, showed a 15–20% reduction in lung cancer deaths in the National Lung Screening Trial — but only among heavy smokers (roughly a pack a day for 20+ years). The risk-benefit math works because the baseline risk in that population is high.Cervical cancer screening — Pap smears and HPV testing — is a genuine public health success story. Rates have dropped dramatically since routine screening began, because cervical cancer has a long, slow, detectable precancerous stage that can be caught before it turns invasive.The common thread: these screenings either catch a long, slow precancerous process, or they target a population where the risk is already high enough that the math clearly favors testing. That's the question worth bringing to your doctor: given my specific risk factors, does the math on this test work in my favor?By contrast, the evidence is much weaker for consumer-marketed total-body scans, full-body MRI as a general “optimization” tool, universal PSA screening in all men over 50, and mammography in average-risk women in their 40s. These aren't mandates — they're conversations, and informed consent means understanding both sides before deciding.The Harms Nobody Talks AboutHealthcare marketing tends to present testing as one-sided: test early, catch it early, save your life. Welch's research catalogs the costs that rarely make it into that pitch.False positives. A mammogram flags a shadow. It isn't cancer — but you don't know that yet. Six weeks of follow-up imaging, maybe a biopsy, and the stress hormones flooding your body during that stretch are a real physiological cost, even when the final answer is “you're fine.”Unnecessary treatment. When a cancer that would never have caused harm is treated anyway — with surgery, radiation, or chemotherapy — the harm is real and the benefit is zero.The cancer label itself. Research shows that being labeled a cancer patient, even for a cancer that's never actively treated, changes a person's psychology, relationships, insurability, and life trajectory. Welch identifies this as a form of harm medicine rarely accounts for.Radiation exposure. Repeated CT scans carry cumulative radiation risk. A full-body scan can expose a person to the radiation equivalent of hundreds of chest X-rays — a real risk added to the body in pursuit of a cancer that may never develop.Welch's central reframe: the question isn't “should I get tested,” it's “given my risk factors, my age, my family history, and my values, does the math on this specific test work in my favor?” That's informed consent — and most people never get that conversation.The Missing Piece: Your Metabolism Is an Early Warning SystemWelch's work is thorough on what not to do. Where it leaves a gap is the proactive question: if blanket screening of healthy people isn't the answer, what is?The answer lies in the years — sometimes decades — before a tumor ever forms. Cancer doesn't appear overnight. The cellular environment that allows it to take root and grow develops gradually, and it leaves metabolic fingerprints long before any scan could detect a tumor.The clearest evidence for this comes from a 2026 study published in Nature Communications, which used machine learning on a massive UK database and linked insulin resistance to a significantly increased risk of at least 12 types of cancer. Pancreatic cancer risk was elevated by roughly 29%, colon cancer by 18%, and breast cancer by 13% — and critically, this risk showed up independent of body weight. A person at a healthy weight can still be carrying the metabolic dysfunction that drives cancer risk, and a standard annual physical would miss it entirely, because most doctors check fasting glucose, not fasting insulin. By the time glucose is elevated, insulin regulation has often been off for years.Layer in chronic inflammation (measured by hs-CRP), elevated ferritin, low vitamin D, rising homocysteine, and a poor triglyceride-to-HDL ratio, and what emerges is a picture of a metabolic environment that is increasingly hospitable to cancer. Think of it as soil: a healthy garden doesn't grow weeds easily, but depleted, imbalanced soil invites them. Cancer is the weed. Metabolic dysfunction is the depleted soil. The strategy, then, is to work on the soil rather than wait to spot the weed.What to Actually Do About ItPath A: Testing to ask your provider forThese tests build a real metabolic picture — the kind that shows soil quality before any weed appears.* Fasting insulin + HOMA-IR — not just fasting glucose. This is likely the single most important test most doctors aren't ordering.* Hemoglobin A1c — your 3-month blood sugar average.* hs-CRP — a high-sensitivity marker of systemic inflammation.* Full lipid panel, including TG/HDL ratio — a ratio above 3 is a strong metabolic red flag.* Ferritin — elevated levels are increasingly linked to inflammatory cancer environments.* Vitamin D (25-OH) — low levels are associated with higher cancer risk across multiple types; optimal is 60–80 ng/mL, not just “in range.”* Homocysteine — a methylation marker that, when elevated, signals oxidative stress.* LDH (Lactate Dehydrogenase) — rises when cells are under metabolic stress.For a deeper look, consider a comprehensive nutrient and organic acids panel (NutrEval), a gut microbiome panel (GI-MAP) — the gut-cancer connection is real — and a full hormone panel including cortisol, estrogen, testosterone, and SHBG.Path B: Lifestyle changes to start today* Eat in this order: protein and fat first, vegetables second, starches last. This alone can meaningfully blunt post-meal blood sugar spikes.* Cut refined sugars and seed oils — the two most direct dietary drivers of insulin resistance and inflammation.* Move daily. At minimum, 150 minutes of moderate activity per week, resistance training twice a week, and even a 10-minute walk after meals to improve glucose metabolism.* Prioritize sleep. Poor sleep disrupts glucose metabolism after a single bad night. Seven to nine hours is non-negotiable for metabolic health.* Manage stress. Chronic cortisol elevation drives insulin resistance — this is biochemistry, not soft advice.You don't need to do all of this at once. Pick one test to ask for at your next appointment, and one lifestyle change to start this week.Summary & Next StepDr. Welch's research makes an uncomfortable but important case: early detection is not automatically synonymous with lives saved, the 5-year survival statistic can be misleading, and testing healthy people carries real costs — false positives, unnecessary treatment, radiation exposure, and the psychological weight of a cancer label. At the same time, some screenings — colonoscopy, cervical cancer screening, low-dose CT for high-risk smokers — have strong evidence behind them and are worth pursuing for the right person.What's missing from that picture is a proactive strategy, and that's where metabolic health comes in. Insulin resistance, chronic inflammation, and blood sugar dysregulation show up years before cancer does, and unlike a full-body scan, they're both measurable and fixable.If you want a clear picture of where your own metabolic terrain stands — and what your highest-leverage next steps are — book a Metabolic Audit Call. It's a complementary 45-minute session where we review your current labs, symptoms, health history, and goals together. Spots are limited each week; the link is in the show notes.References* Welch, H.G. Should I Be Tested for Cancer? Maybe Not and Here's Why. University of California Press.* National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening.* Nature Communications (2026). Machine learning analysis of UK biobank data linking insulin resistance to increased risk across 12 cancer types, independent of body weight.* Thrive 120 Podcast, Episode 126: “Should I Be Tested for Cancer? What Dr. Welch Got Right — And What He Missed,” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit tripleplaydoc.substack.com/subscribe

In this episode of Nurah Speaks, I continue my Know Your Numbers series by focusing on one of the most important health markers we often overlook: cholesterol.After discussing blood sugar and blood pressure in previous episodes, I explain what cholesterol is, why our bodies need it and why it's so important to know your cholesterol numbers before they become a serious health issue.I also encourage all of us—especially within the Black community—to prioritize annual physicals, review our lab results and take advantage of free health screenings if health insurance is a barrier. Prevention and early detection can save lives.In this episode, I discuss:• Why knowing your cholesterol numbers matters• What cholesterol is and the role your liver plays• The difference between LDL ("bad") cholesterol and HDL ("good") cholesterol• How high cholesterol contributes to plaque buildup in the arteries• The connection between high cholesterol, heart disease, heart attacks and stroke• Simple lifestyle changes that can naturally improve cholesterol levels without medications.Please subscribe to Nurah Speaks on YouTube and follow the podcast on your favorite streaming platform.  Be sure to like, share and leave a comment. I would love to hear your thoughts on this conversation.You can follow Nurah Speaks on X, Instagram and Facebook @NurahSpeaks.

In this episode, I sit down with Doug Evans to make the case for the humble sprout as one of the most underrated foods for your heart. Most people push sprouts to the side of the plate as a garnish. Doug and I think that's a mistake.We talk about broccoli sprouts and sulforaphane, the plant compound that research has tied to the NRF2 pathway, glutathione production, and your body's own antioxidant and detox defenses. For me, that matters because oxidative stress and the health of your endothelium sit closer to the root of heart disease than the LDL and HDL numbers most cardiologists chase.Doug also walks through the practical side: which seeds to start with, why three-day-old sprouts are the most potent, how to tell healthy root hairs from mold, and why growing your own runs about a fifth of the grocery-store price. If you want one simple daily habit that lines up with how your body was actually designed to heal, this conversation is worth your time.- - - - -About the Guest:Doug Evans is the co-founder of The Sprouting Company and the author of The Sprout Book, a top-100 Amazon bestseller. A longtime pioneer in the natural-food world, he has spent more than thirty years championing whole, plant-based foods. After moving to the Mojave Desert and landing in a literal food desert, Doug began sprouting nearly all of his own food and turned that experience into a mission to make countertop sprouting simple, affordable, and accessible. He designed The Sprouting Company's growing kit and tracked down high-glucoraphanin broccoli seeds so anyone can grow nutrient-dense sprouts at home in days, without soil, sunshine, or fertilizer.Website: thesproutingcompany.comInstagram: @dougevans | @thesproutingcompanyBook: The Sprout Book- - - - -Jack Wolfson, DO, FACCWebsites: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drjackwolfson.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠; ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://naturalheartdoctor.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/in/drjackwolfson⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ready to move past the confusion and fear of typical heart health approaches? Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠naturalheartdoctor.com/discovery⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to schedule your free discovery call and start your journey toward a 100-year heart with real, evidence-based answers.- - - - -PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Spike Proteins with Dr. Glenn, Beyond Cholesterol & Better Heart Testing with Dr. Dearing [0:00:00] – Intro: Brian Johnson, Longevity & Oxalates + Farmers Market Light banter about: Ed coining the term “peak span” and using it in interviews. Ed's social media success (8.3 million views in 90 days). Joking about Ed doing a shirtless video and his bodybuilding competition and carb loading. Ed talks about Brian Johnson (longevity guru who spends ~$2M/year trying to live to 120): Johnson recently announced an autoimmune condition where his stomach is “eating its own stomach.” Ed admires his data and “Blueprint” protocol but believes two key factors in Johnson's regimen contributed to this issue. Ed teases that one factor is excess oxalate-rich foods; the other factor is left as a teaser for Ed's social media video. Ed announces a weekly farmers market at Nutrition World: Every Wednesday, inside the store, morning to mid-afternoon. Run by a young family with clean farming practices and minimal chemicals. Nutrition World does not profit from it; framed as a service to the community and support for small farmers. [0:05:04] – Upcoming Guests, Ed's E‑Books & Podcasts Ed previews two interviews for this episode: Dr. Glenn – testing and managing spike proteins. Dr. Curt Dearing – discussing his new book “Beyond Cholesterol” and non-traditional views on cardiovascular risk. Ed's e‑books: Six e‑books available on theholisticnavigator.com, including: Quality sleep Oxalates and pain “Are You Sick and Tired?” (diet & overall health) Oral health Immune system “Core Four” foundational supplements Podcasts: Ed mentions his Holistic Navigator podcast Clint promotes Nooga Podcasts (noogapodcasts.com) – a network of 20+ podcasts. [0:09:26] – Interview with Dr. Glenn: What Are Spike Proteins & Why They Matter Dr. Glenn defines spike proteins: Discovered in the 1960s, normally part of viruses from nature. Our immune system usually recognizes and dissolves natural spike proteins. For COVID-era, lab-made spike proteins: They are not recognized properly by the body. They can persist and are not efficiently eliminated. Mechanism (simplified): Spike proteins interact with ACE2 receptors (“locks” on the cell door). They unlock and open the cell doors, enter the cells, and damage/destroy cells from the inside. Clint notes he never heard the term “spike protein” before COVID; Dr. Glenn explains: Previously, they weren't an issue because the body just handled them. This is the first time in history we've dealt with lab-made spike proteins at scale. Dr. Glenn stresses this is not simply vaccinated vs. unvaccinated: mRNA vaccines were designed to produce spike proteins. But unvaccinated people with bad cases of COVID can also carry very high spike levels. His personal story: Got severe COVID in Jan 2020, pre-official naming: 2 weeks very ill on couch/bed. 3 months to feel “recovered,” but that was just the start of long-term issues. Over the next 3+ years, progressive cellular damage accumulated, leading to a broad set of symptoms. Dr. Glenn's symptoms when spikes were very high: Whites of eyes turned gray, with burning eyes all day (constant eye drops). Tinnitus (ringing in ears). Cyclical rashes under armpits. Burning nerves in quads; needed leg massage devices nightly to sleep. Gout attacks (kidneys not handling uric acid well). Venous congestion in lower left leg. Severe fatigue, getting sick frequently despite doing everything “right.” Developed endocarditis (inflammation of heart and valves); resting heart rate jumped from 55–60 to 80–105. Subtle Bell's palsy–type weakness on left side of face and brain symptoms. Laboratory findings: Test: SARS‑CoV‑2 spike protein antibody test (semi-quantitative). Thresholds: 1000: likely too high, potential cell damage. 5000: “a whole other level of danger.” His highest result: 11,694 (measured around Oct 28, 2023). Progress over four tests: 11,694 → 11,087 → ~9,950 → 8,905 (as of June 30, current year). Many symptoms have significantly improved, though: Heart rate better but not back to baseline. Tinnitus persists. Spike level is still high, so work remains. Symptoms can vary dramatically from person to person: Because spikes can enter different “doors” (cells/tissues) in different bodies. One person's profile may be mostly neurological; another's cardiovascular, etc. Dr. Glenn's clinic policy: He will not work with someone on issues like hormones, gut, or cognitive problems without a spike antibody test, because: Otherwise they may be “paddling upstream” against ongoing spike-related damage. Observation: Many patients say: “My doctor says my bloodwork is fine,” yet they feel terrible. Conventional doctors rarely order spike protein antibody tests [0:23:01] – Managing High Spike Proteins: Testing, Risk & Protocol Who Should Test & How: Ed notes frequent COVID infections (he's had it six times) and that many people have unexplained symptoms. Both Ed and Dr. Glenn suggest: Spike antibody testing should be considered for anyone with mysterious chronic symptoms, regardless of age or vaccination status. Testing can be done through labs like Be Well Labs (which Nutrition World works with) or other local options. Reference values: < 0.08 means essentially no exposure to COVID. Out of ~130 tests Dr. Glenn has reviewed, only one person was

Welcome to a most informative and inspiring show about the amazing ancient superfood of cacao! This episode will give you everything you need to know about its remarkable health benefits, healing properties, and how to choose the most sustainable, eco-friendly, fair-trade bean-to-bar products. You will learn about the fascinating history of cacao as a sacred food, currency, and medicine, why it remains one of the most highly regarded superfoods on the planet, and how the food industry took this extraordinary raw material, stripped out everything useful, and transformed it into little more than a heavily sugared version of the original. Along the way, I explain the science in plain English—from the powerful polyphenols that support your heart, brain, blood pressure, gut microbiome, metabolism, and mood, to why cacao may be the single most antioxidant-rich food you can eat. I also reveal the disturbing reality behind much of today's commercial chocolate industry, including how mainstream processing destroys many of cacao's most valuable compounds and why ethical sourcing matters. You'll learn the difference between raw cacao powder, cacao nibs, and high-percentage dark chocolate, how to identify truly high-quality bean-to-bar chocolate, why I became a dark chocolate connoisseur, and the artisan brands I recommend. When this episode is over, you're never going to look at a chocolate bar the same way again, and you'll be fully armed to make the best product purchasing decisions and obtain the maximum benefits from consuming foods high in nutritious cacao. TIMESTAMPS: Cacao is one of the most highly regarded superfoods on the planet. [00:56] When you are finished listening to this episode, you will never look at a chocolate bar the same way again. [02:28] The best way to enjoy chocolate is to put it on your tongue and allow the flavor to dissolve in your mouth. [06:38] The history of cacao is fascinating. It is one of the most nutrient dense, biologically active foods in all of human history. [08:10] Early civilationa learned to ferment, roast, and grind cacao beans into a drink. It was more than a flavoring agent, it was very much a spriitual centerpiece as well as used for medicinal purposes. [10:11] After the Europeans added sugar to cacao, it lost some of its medicinal purpose, although it still is a good source of antioxidants. [12:29] There are many cardiovascular benefits from cacao. It improves platelet function. [18:17] Cacao has been shown in studies to produce meaningful reductions in both systolic and diastolic blood pressure. It is also known to help boost levels of HDL (high density lipoproteins.) [20:55] Cacao consumption improves your overall lipid profiles, including helping with healthy triglyceride levels. [27:24] Does cacao help with weight loss goals? [28:27] Cacao has an impact on brain function and mood. [31:37] In contrast to the powerful, hard and fast effects of caffeine, theobromine in cacao works more slowly. It has a gentler mechanism and a longer half life. [35:08] Studies show wonderful benefits from cacao on the gut. It has been identified as a potent prebiotic which is what feed probiotics to flourish in the intestinal tract. [38:59] Reasearch shows cacao has properties protecting you from UV damage from sunburn. [46:35] Just how damaging to health is mainstream modern chocolate processing? One of the terrible aspects of the low-priced chocolate is because of the support of child slave labor harvesting these beans. [50:02] Look for the designation of "bean to bar" on the product. It should also have cacao beans as the first ingredient. [55:05] In mainstream processing of the beans, they have to use super high temperatures which degrades the polyphenol. [57:17] There are three categories of products which can deliver these wonderful health benefits. [01:00:07] When the bar is above 80%, this is where most of the research showing cardiovascular cognitive benefits was conducted. The words "cacao beans" should be the first ingredient on the label. [01:05:53] Brad lists his recommendations for good chocolate bars. [01:19:44] How much chocolate should one consume? [[01:29:06] Do not refrigerate high quality dark chocolate. [01:32:50] LINKS: Brad Kearns.com BradNutrition.com B.rad Whey Protein Superfuel - The Best Protein on The Planet! Brad’s Shopping Page BornToWalkBook.com B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes Burn The Primal Blueprint Podcast with Shawn Askinosie (Chocolate) Podcast with Todd White (Dry Farm Wine) Dry Farm Wines Askinosie Chocolate Chocovivo Cocoa Runners Nomosu Pump Street Chocolate Puna Chocolate Ranger Chocolate Rausch Spring and Mulberry We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. Seriously, I won’t promote anything that I don't absolutely love and use in daily life: B.rad Nutrition: Premium quality, all-natural supplements for peak performance, recovery, and longevity; including the world's highest quality whey protein! Get 20% OFF your first order! Peluva: Comfortable, functional, stylish five-toe minimalist shoe to reawaken optimal foot function. Use code BRADPODCAST for 15% off! Jaspr Air Scrubber: Ultra high-performance air purifier - blows other air filters away! Save $200 on your unit with code BRAD. Get Stride: Advanced DNA, methylation profile, microbiome & blood at-home testing. Hit your stride the right way, with cutting-edge technology and customized programming. Save 10% with the code BRAD. Online educational courses: Numerous great offerings for an immersive home-study educational experience Primal Fitness Expert Certification: The most comprehensive online course on all aspects of traditional fitness programming and a total immersion fitness lifestyle. Save 25% on tuition with code BRAD! #bradpodcastSee omnystudio.com/listener for privacy information.

If you've ever been told your high cholesterol is "just genetic" and there's nothing you can do but take medication, this episode is for you. I'm sharing the exact, research-backed changes that helped me drop my total cholesterol by 35 points, LDL by 27 points, and triglycerides by 80 points in 12 months, no medication required. As a Registered Dietitian and mom of 3, I'm breaking down the biggest high cholesterol myths (starting with the dietary cholesterol myth, yes, eggs are fine!) and walking through the lifestyle and nutrition shifts that actually move the needle on cholesterol naturally. In this episode, you'll learn: Why eating cholesterol-containing foods like eggs and shrimp isn't the real problem The truth about genetics and high cholesterol, predisposition isn't destiny How strength training and walking impact LDL, HDL, and triglycerides Why added sugar (not dietary fat) is one of the biggest drivers of high cholesterol The role of fiber in naturally lowering LDL cholesterol Cholesterol-supportive supplements to ask your doctor about: omega-3s, vitamin D, berberine, turmeric/ginger, plant sterols How blood sugar regulation ties directly into healthy cholesterol levels My personal before-and-after lab numbers after one year of consistency Disclaimer: This episode is for educational purposes and isn't a substitute for medical advice. Always talk to your doctor before starting supplements or adjusting cholesterol medication. Want pre-balanced meals that support healthy cholesterol without tracking or giving up your favorite foods? Join us inside Busy Mom Meals  Come hang out with me on Instagram @nutrition.for.mamas

In today's episode, Randy Vawdrey dives into cardiovascular prevention with a special focus on coronary artery calcium (CAC) testing. He guides us through why traditional cardiovascular risk factors like LDL cholesterol, HDL, and BMI may not be as predictive of heart attack risk as once thought, and how CAC scores can provide a much clearer picture.You'll hear about the latest research, practical steps for interpreting CAC scores, and the lifestyle and supplemental interventions that can help halt the progression of cardiovascular disease. Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardioTIMESTAMPS: 00:00 Discussing cardiac risk assessment factors05:50 Predictive value of CAC scores07:17 Understanding Agatston scores10:22 Boulder cardiologist's health tips13:52 Discussing methylfolic acid and statins16:42 Managing stress with coronary scores20:17 Podcast sponsor shout-out and disclaimersSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

"The idea of metabolic scoring is to take guilt out of the picture. Because this is not anyone's fault. It's basically a cosmic shift in just our whole lifestyle here in Western civilization." — Dr. Ron HunninghakeIn this episode of the Real Health Podcast, Dr. Ron Hunninghake and Dr. Drew Rose discuss the complexities of metabolic syndrome, its prevalence in the Western world, and the lifestyle factors contributing to it. They emphasize the importance of identifying root causes and implementing personalized health strategies to combat this growing epidemic.

Wylecz Insulinooporność!---Witamy serdecznie w kolejnym odcinku! Przed Wami program pod patronatem Polskiego Towarzystwa Leczenia Insulinoporności, a nasz cel jest jeden: edukacja, bo zdrowie zaczyna się od wiedzy!  W tym odcinku: ·       Błędne koło metaboliczne – jak nadmiar insuliny niszczy naczynia krwionośne, prowadząc bezpośrednio do nadciśnienia i miażdżycy.·       3 proste wskaźniki (Zamiast cholesterolu) – jak za pomocą HOMA-IR, trójglicerydów i HDL realnie ocenić ryzyko zawału.·       Insulina a nowotwory – w jaki sposób hiperinsulinemia karmi guzy, stymuluje ich wzrost i przyspiesza starzenie komórkowe.·       Pułapka lekowa (Ważne!) – dlaczego nagłe przejście na keto przy lekach na cukrzycę (np. Jardiance) wymaga ogromnej ostrożności i wiedzy.  Wskakuj na naszą stronę https://braciarodzen.pl/wakacje-z-bracmi-rodzen/ i zapisz się do tej akcji czeka na Ciebie mnóstwo wiedzy slajdy oraz praktyczne prezenty. Słuchajcie nas regularnie we wtorki, środy i czwartki o 21:00. Subskrybujcie podcast, zostawcie łapkę w górę, udostępniajcie i do zobaczenia w kolejnym odcinku!--- Akcja Wylecz Insulinooporność! -  pod patronatem: Polskiego Towarzystwa Leczenia Insulinooporności!https://ptli.pl/ ====Ważne: Nasz podcast może być emitowany z opóźnieniem w stosunku do odcinków na żywo. Promocje i informacje o wydarzeniach mogą być nieaktualne. Aktualne informacje znajdziesz na naszej stronie lub innych kanałach – linki poniżej.====Jeśli to, co robimy, jest dla Ciebie wartościowe, spraw, aby inni mogli to odkryć – udostępnij ten podcast i zostaw ocenę! ⭐⭐⭐⭐⭐ Twoja opinia ma znaczenie i pomaga nam docierać do kolejnych osób, które potrzebują tej wiedzy. Dziękujemy za Twoje wsparcie!Dołącz do NIEZALEŻNIE MYŚLĄCEJ i pięknie żyjącej społeczności

Get the 200+ Page Optimal Living Daily Workbook (PDF) — Free. Want to turn today's episode into an actionable plan? Join the Optimal Living Weekly newsletter and I'll send you our 200-page digital workbook immediately. It's packed with the best takeaways from the show, formatted for easy reading and implementation at home. Get your free PDF workbook here: ⁠https://oldpodcast.eo.page/join⁠ Discover all of the podcasts in our network, search for specific episodes and learn more at:⁠ OLDPodcast.com⁠. Episode 3456: Sophie Szczudlo explores why foods like açaí, kale, quinoa, and chia seeds have earned the “superfood” label and explains that many ordinary whole foods offer similar nutritional benefits. Rather than chasing trendy ingredients, she emphasizes that a varied diet of fresh, minimally processed foods is what truly supports long-term health. Read along with the original article(s) here: https://idealnutrition.com.au/the-hype-about-superfoods/ Quotes to ponder: "The key is to eat a variety of fresh wholefoods so that all food groups can work in synergy to benefit your overall health." "Goji berries are allegedly able to boost immunity and brain activity and protect against cancer." "Omega-3 can aid in fighting inflammation and can help reduce the risk of developing cardiovascular disease by raising the HDL or the ‘good cholesterol' in our blood." Learn more about your ad choices. Visit megaphone.fm/adchoices

Get the 200+ Page Optimal Living Daily Workbook (PDF) — Free. Want to turn today's episode into an actionable plan? Join the Optimal Living Weekly newsletter and I'll send you our 200-page digital workbook immediately. It's packed with the best takeaways from the show, formatted for easy reading and implementation at home. Get your free PDF workbook here: ⁠https://oldpodcast.eo.page/join⁠ Discover all of the podcasts in our network, search for specific episodes and learn more at:⁠ OLDPodcast.com⁠. Episode 3456: Sophie Szczudlo explores why foods like açaí, kale, quinoa, and chia seeds have earned the “superfood” label and explains that many ordinary whole foods offer similar nutritional benefits. Rather than chasing trendy ingredients, she emphasizes that a varied diet of fresh, minimally processed foods is what truly supports long-term health. Read along with the original article(s) here: https://idealnutrition.com.au/the-hype-about-superfoods/ Quotes to ponder: "The key is to eat a variety of fresh wholefoods so that all food groups can work in synergy to benefit your overall health." "Goji berries are allegedly able to boost immunity and brain activity and protect against cancer." "Omega-3 can aid in fighting inflammation and can help reduce the risk of developing cardiovascular disease by raising the HDL or the ‘good cholesterol' in our blood." Learn more about your ad choices. Visit megaphone.fm/adchoices

GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption. Source: https://www.nature.com/articles/s43856-026-01566-x ~~ GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy. Sources: https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498 https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds ~~ Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk. Source: https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn ~~ Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost. Sources: https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/ https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/ ~~ Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations. Source: https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/ ~~ New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, and in mouse studies, strawberries reduced colitis activity only in mice with an intact microbiome. Host Dave Asprey explains why the plant itself isn't the active ingredient, your bacteria are, and connects the findings to this year's Environmental Working Group Dirty Dozen and Clean Fifteen lists to help listeners decide where organic actually matters. Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC12768975/ https://www.eurekalert.org/news-releases/1108351 https://www.nature.com/articles/s41564-025-02197-z ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into the gut-brain axis, an underreported GLP-1 side effect, a global parasite hiding in plain sight, the real ROI of exercise on mental health, consolidation in the supplement industry, and how your microbiome determines what your produce actually does for you. Host Dave Asprey connects clinical research, large cohort studies, mechanistic biology, and industry news into practical frameworks for improving gut health, brain performance, and long-term resilience. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: plasma acetate gut brain axis, short chain fatty acids, gut microbiome cognition, GLP-1 smell taste disturbances, anosmia parosmia GLP-1, semaglutide side effects, toxoplasmosis neglected tropical disease, Toxoplasma gondii health risks, congenital toxoplasmosis, exercise mental health study, exercise versus income happiness, overtraining mental health, Unilever Thorne acquisition, supplement industry consolidation, phytonutrient gut bacteria enzymes, polyphenol metabolism microbiome, Dirty Dozen Clean Fifteen 2026, pesticide residue produce, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Story #1: Acetate & Gut-Brain Health 01:57 – Story #2: GLP-1s & Smell/Taste Loss 03:22 – Story #3: Toxoplasmosis Risks 04:33 – Story #4: Exercise vs Income 05:53 – Story #5: Phytonutrients & Gut Enzymes 07:45 – Dirty Dozen & Clean Fifteen 08:46 – Story #6: Thorne Acquisition 09:49 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Brian has been on a carnivore diet for almost 4 years. He was very overweight most of his adult life. In 2018, he developed A-Fib, and was having 2-3 paroxsymal A-Fib episodes per week before starting carnivore. Lower back and hip pain were so bad that he couldn't sleep longer than a couple of hours in bed at night. Brian also struggled with low energy, mild depression, joint pain, arthritis in his big toe, high triglycerides, low HDL, and low vitamin D. Within a few weeks on carnivore Brian was sleeping all night in bed, joint pain was going away, and he noticed A-Fib episodes were not happening. He lost 60 pounds in the first 3 months and 85 pounds over the first year and has maintained that weight loss since starting carnivore in July of 2022. Brian has gone over 3 1/2 years without a single A-Fib episode. His cardiologist has had him wear a heart monitor multiple times, including once for 30 days, and participate in a stress test and ultrasounds, showing no evidence of going into A-Fib anymore.  In November of 2025 Brian had a CAC scan and it was 0. His HDL is improved and triglycerides are way down. His Vitamin D level is normal, and no longer has issues with joint pain or arthritis in the big toe. Starting carnivore at age 48, Brian is now 52 years old and feeling better than he did in his 30's. Socials: YouTube - @wickivore Timestamps: 00:00 Trailer 00:22 Introduction 05:52 Increasing joint flare-ups 08:07 First heart diagnosis 09:41 Struggles with restrictive dieting 12:49 Discovering the Carnivore Diet 15:58 Discussing keto-friendly foods 20:48 Carnivore diet and joint health 24:30 Finding a flexible doctor 28:35 Personal transformation and health concerns 32:09 Positive changes after diet switch 35:13 Early days of carnivore diet 37:54 Carnivore diet's growing popularity 41:45 Impact of Joe Rogan on Diet Trends 43:41 Avoiding unhealthy products Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

It's In the News - a look at the top diabetes headlines and stories happening now. Our top stories: More information about type 1 and COVID, including the vaccine, why is the latest GLP-1 medication, not yet FDA approved, showing up all over the place, what table sugar and vinegar could mean for drug costs, a new inhaled insulin study and much more  I'll see you at Friends for Life next week. Come find me at Table T18 Learn more about our in-person events here: https://diabetes-connections.com/events/ Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Transcript & links:    Okay.. our top story this week: XX A large Swedish study found that the increased risk of being diagnosed with type 1 diabetes after COVID-19 infection is mostly limited to the first 30 days after infection and does not continue long term. Researchers followed nearly the entire Swedish population under age 80 from 2020 through 2023 and found that while SARS-CoV-2 infection was linked to a temporary rise in new type 1 diabetes diagnoses, the risk declined over time. The study also found no evidence that COVID-19 vaccination increases the long-term risk of developing type 1 diabetes. Vaccination did not significantly change the relationship between COVID-19 infection and diabetes risk, and any small increase in diagnoses seen among adults shortly after a first vaccine dose was not seen after later doses or during longer follow-up. The researchers concluded that their findings do not support changing current COVID-19 vaccination recommendations because of concerns about type 1 diabetes risk. https://www.infectiousdiseaseadvisor.com/news/covid19-infection-may-increase-short-term-type-1-diabetes-risk/ XX Two new studies are challenging the traditional view that type 1 diabetes develops solely because the immune system attacks insulin-producing beta cells. Researchers from Indiana University found evidence that beta cells themselves may play an active role in determining whether they survive or succumb to the stresses that lead to type 1 diabetes. In the first study, scientists discovered that some healthy human beta cells can quickly activate an antiviral defense system when exposed to interferon-alpha, an immune signal often produced during viral infections. This response relies on molecules called reactive oxygen species (ROS), which are usually associated with cell damage but, in this case, appeared to help switch on protective antiviral genes. Researchers found this defense program in healthy cells and in people at risk for type 1 diabetes, but not in beta cells from people who already had the disease. The findings suggest that losing this built-in defense mechanism may make beta cells more vulnerable during the development of type 1 diabetes. The second study focused on autophagy, the process cells use to recycle damaged or worn-out components. Using a new imaging technique, researchers observed that beta cells in a mouse model of type 1 diabetes showed defects in autophagy before blood sugar levels began to rise and even before a full immune attack was underway. This suggests that problems inside the beta cells may occur early in the disease process rather than being caused entirely by the immune system. Together, the studies point to a more complex picture of type 1 diabetes. While they do not show that beta-cell defects cause the disease, they suggest that differences in how beta cells respond to stress, viral signals, and cellular damage may influence who develops type 1 diabetes and how the disease progresses. https://medicalxpress.com/news/2026-06-beta-cells-players-diabetes.html XX Researchers have created the most detailed map yet of how the human pancreas develops during childhood, offering new clues about why children are especially vulnerable to developing diabetes. The study, published in Nature Communications, examined pancreatic tissue from 123 children without diabetes, ranging from newborns through age 10. Using advanced imaging techniques, scientists tracked how insulin-producing islet cells grow and mature during the first decade of life. The researchers found that pancreas size varies dramatically at birth, with some infants having pancreases nearly four times larger than others. They also discovered that insulin-producing beta cells grow more slowly after birth than previously thought, suggesting that much of a person's lifelong beta cell capacity may be established before birth and during early childhood. Other findings showed that insulin-producing cells mature earlier than glucagon-producing cells and that new hormone-producing cells may continue to form after birth. The researchers hope this new understanding of pancreas development will help scientists identify diabetes risk earlier and develop better strategies for prevention and treatment in children. https://news.vumc.org/2026/06/29/unlocking-diabetes-secrets-pediatric-organ-donors-help-map-a-path-to-a-cure-and-prevention/   XX At the American Diabetes Association annual meeting, 2-year results from the SUPPRESS-EARLY trial showed that initiating tirzepatide (Mounjaro, Zepbound) early in the course of type 2 diabetes led to substantially higher rates of near-normal glycemic control and also led to broader metabolic improvements compared with intensive conventional therapy.   In this MedPage Today video, investigator Stefano Del Prato, MD, of the University of Pisa in Italy, discusses the findings.     Following is a transcript of his remarks:   What happened is that in the tirzepatide-treated arm, 85% of the population at the end of the second year was on the maximum dose of tirzepatide 15 mg. And then the remaining 15 with the different doses.   Interestingly, in the population that had been treated with the intensive conventional approach, 85% of them ended up to have, on top of metformin, a GLP-1 receptor agonist, mainly represented by subcutaneous semaglutide [Ozempic, Wegovy], 60+%, another 15% on oral semaglutide [Rybelsus], and the remaining on dulaglutide [Trulicity].   And I have to say that maybe the recommendation to really push along the line to try to achieve and to strive to achieve [glycemic] control was successful in these individuals. Because the population that had been recruited in the study started off with a baseline A1C of 7.8% and it went down to 6.3% in the conventionally intensive treatment, which is not bad at all, on average is below the target of 6.5%.     However, when we look at the effect of tirzepatide, the final level of A1C at the end of the second year was 5.6%, which is on average below the upper limit of the normal range for A1C, 5.7%. This also translates into more people not only achieving normal glycemia, if we can define normal glycemia as A1C below 5.7%, greater than what we observed in conventionally treated individuals. So it was around three times more people achieving an A1C of 5.7%, in the range of around 65%, as compared to 28% with people on a conventional optimized treatment.   Now, this is not surprising knowing the potency of tirzepatide. But again, going back to the rationale of the design, can we change what is the natural history of the disease? This seems to be at least of interest and it's possibly changing the trajectory of the disease for glycemic control, as I mentioned, but also in terms of the body weight and waist circumference because both body weight and waist circumference went much lower with tirzepatide compared to the conventional treatment.   Tirzepatide also was associated with an improvement in the lipid profile, in particular with the LDL, triglycerides, and the triglyceride concentration and non-HDL cholesterol, and also with a statistically significantly lower systolic blood pressure with a numerical reduction in the diastolic blood pressure.   And also the other thing that probably will ... become more apparent with the study continuing is that the investigators were allowed to add on any other treatment ... needed to achieve their target. So tirzepatide was just metformin and tirzepatide. In the control group, there was already 10% of people who were receiving two drugs on top of the metformin.   So another potential result of the trial is that it's possible to achieve and maintain better glycemic or better metabolic control over the time without really needing to increase the number of medications in order to achieve that goal. And we know that type 2 diabetes is a progressive condition often requiring intensification of the treatment.   So these initial results really stand for a great opportunity with tirzepatide. Of course, we need to wait for the 4 years just to confirm that this is indeed the case, but the initial result seems to point along that line. https://www.medpagetoday.com/meetingcoverage/adavideopearls/121967 XX A study from the University of Virginia found that high blood pressure is extremely common among people with diabetes, even among those who believe their blood pressure is under control. Researchers measured blood pressure in 172 adults with type 1 or type 2 diabetes during routine eye clinic visits and found that only 8% had normal readings. About half had stage 2 hypertension, and more than 10% had blood pressure levels high enough to be considered a medical emergency. The study also revealed that many patients were unaware of how serious their blood pressure problems were. Among those who thought their hypertension was well controlled, more than half still had stage 2 hypertension. Nearly 60% of participants were advised to contact their primary care provider, and one patient required an emergency department referral. Most patients supported blood pressure screening during eye exams, leading researchers to suggest that routine blood pressure checks in ophthalmology clinics could help identify undiagnosed or poorly controlled hypertension before it leads to serious complications such as heart attack, stroke, or worsening diabetic eye disease. https://medicalxpress.com/news/2026-06-routine-eye-exams-reveal-stage.html XX What is going on with retatrutide? This is the next generation GLP-1 but it's not authorized outside of clinical trials. Big investigation by CBS shows retatrutide is for sale all over the internet, a phenomenon they say has no modern precedent. CBS News identified more than 120 websites selling or promoting retatrutide, including more than 50 clinics staffed by licensed medical professionals. After being contacted by CBS News, at least 21 clinics abruptly removed retatrutide from their websites or changed the language to state they don't offer it. Others defended prescribing it, saying they're confident enough in results from clinical trials sponsored by drugmaker Eli Lilly that they didn't need to wait for the FDA's independent, rigorous review. An FDA spokesperson said retatrutide "has not been found safe or effective for any condition," adding that it "cannot be manufactured or distributed except for investigational use." The Justice Department is prosecuting two cases – in Utah and Florida – involving the sale and prescription of retatrutide. But the first line of enforcement is often at the state level. Ohio's Board of Pharmacy has taken action against several pharmacies and clinics providing retatrutide, and just last month, Alabama's Medical Board warned physicians against prescribing research-grade medications. The FDA has sent 14 warning letters to companies that have advertised retatrutide since 2024. Of these, at least six have continued to offer it online, including a business called Pink Pony Peptides. A TikTok account associated with the firm responded to the warning in April by taunting the FDA, boasting that the business "just had the best 24 hours ever." In May, Eli Lilly announced that participants in a large clinical trial taking the highest dose of retatrutide lost an average of 28% of their body weight over 80 weeks. Side effects – including nausea, diarrhea, constipation and vomiting – were comparable to similar therapies, the company said. "Anyone purporting to sell retatrutide to consumers is breaking the law," an Eli Lilly spokesperson said https://www.cbsnews.com/projects/2026/experimental-weight-loss-drug/ XX Pioneering research has developed a new way of creating carbohydrate-based medicines, which could ultimately replace costly drugs for common health conditions, using two cheap basic ingredients – table sugar and vinegar. These medications include SGLT2 inhibitors, widely prescribed drugs used to treat type 2 diabetes, heart failure and chronic kidney disease. Co-lead author Professor Phil Baran, Dr. Richard A. Lerner Endowed Chair at Scripps Research, in San Diego, California, said: "The point of this is to show that anyone in a garage can make an SGLT2 inhibitor with reagents that are widely available. We have not patented this method, so we welcome any generic drug company – or anyone else – who wants to use it to help bring costs down for patients." https://www.newswise.com/articles/new-study-shows-table-sugar-could-hold-a-cheaper-quicker-key-to-making-vital-drugs-for-diabetes-heart-failure-and-chronic-kidney-disease XX England and Wales approve teplizumab to slow progression of T1D. At the moment, the Scottish Medicines Consortium does not have an appraisal of Tzield on the go, so, there is likely to be a disparity in access within the UK for the time being. In Northern Ireland, access will depend on a review and adoption of NICE guidance.  Sanofi is expecting to see an uptick in momentum thanks to two subsequent FDA approvals, one in children as young as one with stage 2 T1D, and a second to delay the decline in endogenous insulin production in children aged eight to 17 years recently diagnosed with stage 3 T1D. btw you might here more people referring to stage 4 diabetes. They've added that to include people diagnosed with type 1 who've been on insulin for a longer period of time – basically long enough to not be eligible for the current guidelines for Tzield. https://www.bbc.com/news/articles/ce8mzd94r76oXX XX Obesity Association, a division of the American Diabetes Association® (the association), announced the next section in the Standards of Care in Overweight and Obesity, "Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults," published in Diabetes, Obesity, and CardioMetabolic CARE® and BMJ Open Diabetes Research & Care.  Key highlights of the guidance: Early screening: Annual BMI screening with emphasis on tracking weight trends to identify risk earlier, including a longitudinal life-event weight graph tool for standardized assessment. Enhanced diagnosis: Combines BMI with waist measurements and population-specific thresholds to improve accuracy. Notably, the guidelines recommend that BMI in the overweight range together with central adiposity measurements warrant a formal obesity diagnosis. Comprehensive evaluation: Holistic assessment including medical, behavioral, and social factors. Offers a fully integrated obesity diagnostic algorithm. Risk stratification: Use of tools like the Edmonton Obesity Staging System to guide care. Chronic care approach: Ongoing monitoring and follow-up to support long-term management. Reducing bias: Promotes person-centered, non-stigmatizing care and system-level improvements at the clinical workflow level and encourages screening for prior weight bias/stigma experiences. https://www.prnewswire.com/news-releases/new-standards-of-care-in-overweight-and-obesity-section-screening-diagnosis-evaluation-and-staging-of-obesity-in-adults-302809670.html XX Dexcom (Nadsaq:DXCM) today announced the launch of its fully reimagined Stelo over-the-counter (OTC) sensor app experience. San Diego-based Dexcom plans to formally begin the new app rollout in July for Apple iPhone and Android users in the U.S. Dexcom said its reimagined app aims to make glucose insights easier to understand and act on. It hopes to help build awareness of how food, activity, sleep and stress influence overall wellbeing.   The company also reiterated plans to launch Stelo internationally. It expects to bring the sensor to the UK, Australia, New Zealand and South Korea later this year, continuing into 2027. https://www.drugdeliverybusiness.com/dexcom-launches-enhanced-stelo-app/ XX MannKind Corporation recently announced it received a grant from Breakthrough T1D to support the INHALE-1 clinical study of Afrezza, its ultra rapid-acting inhaled insulin, in newly diagnosed pediatric type 1 diabetes patients aged 10 to under 18 years. This external funding for a trial focused on early use of Afrezza in children highlights growing third-party support for inhaled insulin in pediatric diabetes care. https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-mnkd/mannkind/news/afrezza-pediatric-trial-grant-might-change-the-case-for-inve XX Alexander Zverev heads into Wimbledon with plenty of momentum. The French Open champion returns to the All England Club looking to build on his first Grand Slam title and gain ground on Carlos Alcaraz in the race for the No. 2 spot in the ATP rankings. Zverev has an opportunity to make up points quickly after a first-round exit at Wimbledon last year. But his final tune-up before Wimbledon came with an unexpected challenge. During his semifinal loss to Taylor Fritz at the Halle Open, Zverev said a malfunctioning glucose sensor led to serious diabetes management issues on court. The sensor incorrectly showed his blood sugar was high when it was actually low, causing him to take more insulin than needed. "I had huge problems with the sugar because the sensor I use gave me a completely incorrect reading," Zverev said after the match. "During the match, or rather during the first 45 minutes, I had to consume about 350 grams of sugar. I felt absolutely terrible." Despite feeling unwell, Zverev pushed the match to three sets before falling 6-7(4), 6-4, 7-5 to Fritz. He credited his opponent with playing the better match and said the diabetes-related issue was not an excuse for the result. Zverev, who was diagnosed with type 1 diabetes at age 4, uses Medtronic diabetes technology to help manage his glucose levels while competing on the ATP Tour. He said the sensor error was the first major problem he has experienced after nearly a decade of using the technology. The German said the incident should not affect his Wimbledon preparations. With the sensor issue behind him, Zverev will begin his Wimbledon campaign focused on adding another strong result to what has already been a breakthrough season.   https://www.reuters.com/sports/tennis/zverev-says-glucose-sensor-malfunction-affected-halle-semi-final-loss-fritz-2026-06-21/

“Physical activity is really such a linchpin in being able to change the trajectory of how you age.” — Dr. Susan Brian  “Resistance training is probably your most proactive tool under your control for trying to reduce your risk of developing metabolic syndrome.” — Dr. Jocelyn Wittstein  Key Links & Resources  Subscribe to Age Better Cheat Sheet on Substack HERE  Follow Barbara Hannah Grufferman on Instagram HERE  Follow Dr. Susan Brian on Instagram HERE  Follow Dr. Jocelyn Wittstein on Instagram HERE    Episode Summary  Metabolic syndrome is not one single disease. It's a cluster of warning signs — including waist size, blood pressure, triglycerides, HDL cholesterol, and blood sugar — that together can tell a much bigger story about your health.  And for women in their 60s, this matters because metabolic syndrome is not just about lab numbers. It can affect your risk for type 2 diabetes, heart disease, fatty liver disease, sleep apnea, inflammation, bone health, muscle quality, mobility, and physical capacity.  In this episode of AGE BETTER, I talk with two leading physicians: Dr. Susan Brian, a board-certified endocrinologist and menopause specialist, and Dr. Jocelyn Wittstein, an orthopedic surgeon and sports medicine specialist at Duke.  Together, they explain why metabolic syndrome becomes more common after menopause, how visceral fat and insulin resistance can affect the body, and why this issue is deeply connected to how strong, mobile, energetic, and independent you feel as you age.  You'll learn:  What metabolic syndrome is and why having three of the five key markers matters  Why insulin resistance is often at the center of the pattern  How menopause can shift fat storage toward more visceral belly fat  Why metabolic health and musculoskeletal health are closely connected  How metabolic syndrome can affect muscle, bone, joints, stamina, and frailty risk  Why muscle is so important for blood sugar control  Why walking, strength training, and “starting somewhere” can make a real difference  What to ask your clinician if you think you may have metabolic syndrome or be heading in that direction  Where GLP-1 medications may fit for some women — and why strength training matters if weight loss is part of the plan  The big takeaway: metabolic syndrome is not just about weight. It's about how your body is functioning — and the earlier you recognize the pattern, the more opportunity you have to change the trajectory.  Dr. Brian encourages women to know their numbers, advocate for themselves, and figure out what kind of physical activity they can do consistently.  Dr. Wittstein emphasizes resistance training, starting where you are, and building the right team around you — because protecting muscle, bone, mobility, and strength is central to aging better.  Calls to Action  If this episode helped you, please follow or subscribe to AGE BETTER wherever you listen to podcasts.  Share this episode with a friend, sister, partner, or anyone who wants to stay strong, healthy, and independent as they get older.  And make sure you subscribe to Age Better Cheat Sheet on Substack, where I go deeper into the newest research on healthy aging and break down what it means for you.  Have an idea for a future episode or a question you want answered? Email me at agebetterpodcast@gmail.com.  

Most of us assume that if we look healthy on the outside, our heart is fine on the inside, but today, preventive cardiology dietitian Michelle Routhenstein explains why that's exactly the assumption that gets women into trouble, especially through perimenopause and beyond. We get into the two numbers your doctor probably isn't checking, ApoB and Lp(a), the first five diet changes Michelle makes with clients to bring down high cholesterol numbers, why stretching may be doing as much for your arteries as it does for your joints, and why blood pressure, not HRV, deserves far more of your attention as you move through this life stage. WHAT YOU'LL LEARN ●      Why heart disease can silently progress in women who look and feel healthy ●      What ApoB and Lp(a) actually measure, and why they matter more than LDL and HDL alone ●      The first five diet changes to lower high ApoB or non HDL cholesterol ●      Why saturated fat, fiber, and gut health all influence your cholesterol numbers ●      Why blood pressure, not HRV, deserves more of your attention in perimenopause ●      How menopause hormone therapy really affects your cardiovascular risk ●      The minerals your heart needs to keep beating and pumping properly TIMESTAMPS 00:00 Heart Disease Risk in Women: ApoB, Lp(a), and the Tests Your Doctor Isn't Running 10:18 The Hidden Inflammation Driving Your Heart Disease Risk (And How to Test for It) 19:29 The Truth About Saturated Fat and Cholesterol After 40 22:19 The First Five Diet Changes to Lower High ApoB or Non HDL Cholesterol 29:24 Bloating, Gut Health and Thyroid: The Hidden Heart Disease Risks in Perimenopause 39:41 Why Stretching Might Be Protecting Your Arteries, Not Just Your Joints 51:48 Does Menopause Hormone Therapy Actually Protect Your Heart? VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.

Are you worried about your cholesterol levels on your labs continuing to climb?     While conventional medicine bloodwork typically focuses on total cholesterol, LDL, and HDL, these markers don't always provide a complete picture of cardiovascular risk.     The good news is there's a more accurate marker called ApoB that can offer deeper insight. On today's show, I want to break down what ApoB is, why it matters more than traditional cholesterol markers, and the 7 most effective ways you can naturally lower it.     Tune into today's Cabral Concept 3786 to learn how to lower your ApoB naturally and support long-term heart health through simple, foundational lifestyle changes.     Enjoy the show, and let me know your thoughts!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3786 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Are eggs bad for you because they may raise cholesterol?It's one of the most common nutrition questions in cardiology, and one of the most misunderstood. The reality is that raising cholesterol and harming your health aren't always the same thing, and when it comes to eggs, the data tells a much more nuanced and reassuring story than most people have been led to believe.In this conversation, Dr. Bret Scher walks through the science of eggs, cholesterol, and cardiovascular risk, cutting through decades of nutritional confusion to help you understand what it actually means for your individual dietary choices.You'll learn:Why the original "eggs cause heart disease" logic doesn't hold up under scientific scrutinyWhat happens to LDL and HDL when most people eat whole eggsWho the "egg hyper responders" are and what genetics has to do with itWhy hazard ratios in observational egg studies are often clinically unhelpfulWhat the American Heart Association now says about eggs and cardiovascular riskWhy eggs are one of the most nutrient dense whole foods availableHow to think about egg quality, quantity, and individual responseThe takeaway: eggs can be part of a healthy whole foods dietary pattern for most people. Context, metabolic health, and the totality of your diet often matter far more than any single food.

Matthew "Oki" O'Connor is the CEO of Scientific Affairs at Cyclarity Therapeutics, a clinical-stage biotech building a new class of medicines designed not to slow the accumulation of vascular damage but to reverse it. Oki and Chris first crossed paths as postdocs at Lawrence Berkeley National Lab in the mid-2000s — Oki was in Irina Conboy's lab, not far from the late Judy Campisi's group, where Chris was then working on cellular senescence. After Berkeley, Oki spent nearly a decade running the research program at the SENS Research Foundation, the organization most identified with the "damage repair" framing of aging biology, before co-founding Cyclarity (then known as Underdog Pharmaceuticals) in 2019 to translate one of SENS's most drug-tractable ideas into an actual molecule.When Oki was last on the show in March of 2023 (Episode 36), Cyclarity was deep in IND-enabling work and its lead asset, UDP-003, had only ever seen the inside of a mouse artery. At the end of that conversation, Chris asked what Oki hoped to be discussing the next time he visited. He answered, bluntly, that he wanted to be presenting human data. Last month, at the AHA Vascular Discovery Sessions, Cyclarity reported the results of their first-in-human Phase 1 trial of UDP-003 — a designed cyclodextrin that selectively binds 7-ketocholesterol, the oxidized cholesterol species that drives foam cell formation and arterial plaque. He's back to discuss what the drug actually did when it went hunting for 7KC inside a living human being.In this episode, Chris and Oki cover the unmet need that lipid-lowering drugs — statins, PCSK9 inhibitors, the coming Lp(a) agents — still don't address: none of them remove the damage already sitting in an artery wall. Oki explains the basic chemistry of 7-ketocholesterol and why macrophages, lacking the machinery to recycle it, collapse into foam cells and seed the necrotic core of advanced plaque. They walk through the engineering of UDP-003 as a dimeric beta-cyclodextrin "double cone" tuned for a single oxidized cholesterol species, the design of the 72-volunteer Australian Phase 1, and the exploratory pharmacodynamic readout that has the field's attention: dose-dependent urinary excretion of 7KC, stoichiometric with drug, cleared within a day. The conversation then turns to the 150-patient Phase 2 plan in coronary artery disease patients with plaque imaging as the primary biological readout, the funding math that stands between Cyclarity and that trial, the platform's reach into NASH, vascular dementia, AMD, and aging itself, and how all of this descends from the SENS damage-repair philosophy that Oki has been carrying since LBL.The Finer Details:- Why current standard of care is not enough — statins, PCSK9 inhibitors, GLP-1s, and the soon-to-arrive Lp(a) lowering agents all act by slowing the accumulation of arterial damage, not by reversing what's already there; despite 30 years on the market, statins have never demonstrated an all-cause mortality benefit in a clinical trial, and even the best statin imaging data shows only 1–2% plaque volume regression at very high doses in a subset of patients- The scale of the problem — atherosclerosis is estimated to contribute to roughly 40% of all human deaths once heart attack, stroke, and a surprisingly large COPD contribution are risk-adjusted in, on top of an enormous morbidity tail that includes angina, peripheral artery disease (up to and including amputation), and a growing case for vascular dementia as an undercounted driver of cognitive decline- The biology of 7-ketocholesterol — when an oxygen free radical reacts with cholesterol, it preferentially attacks the 7 position, and a second oxidation step locks the molecule into 7KC, a stable toxic species cells were essentially never equipped to recycle; it builds up in long-lived cells like macrophages, eventually shutting down their ability to traffic lipids back to the liver via HDL and converting them into foam cells that seed soft plaque and, over years, the necrotic core of advanced lesions- The molecular design of UDP-003 — cyclodextrins are naturally occurring carbohydrate rings; the beta size fits half a cholesterol molecule, and Cyclarity's in silico work showed that two beta-cyclodextrins facing wide-side to wide-side form a "double cone" that can fully encapsulate a single cholesterol; engineered correctly, that wrapper can be made selective for 7KC over native membrane cholesterol, which is what gives the drug its therapeutic window- The Phase 1 trial design and result — a traditional 72-volunteer safety study in Australia, split between single ascending dose and multiple ascending dose arms, escalating up to six doses at what Cyclarity believes will be the efficacious level; no serious adverse events, no bioaccumulation, drug excreted essentially completely in the urine (as predicted preclinically), and — the headline exploratory endpoint — dose-dependent urinary 7-ketocholesterol appearing on the same timescale as the drug, consistent with one molecule of UDP-003 binding one molecule of 7KC and leaving the body together- What the urinary 7KC readout can and cannot tell you — the easiest 7KC to mobilize is the free pool in circulation, but there is not nearly enough of it floating in the bloodstream to account for what came out in urine, which means the drug is reaching deeper compartments; how much is coming from vessel wall plaque versus liver versus other peripheral tissues will require the imaging endpoints of Phase 2 to answer- The Phase 2 plan — 150 coronary artery disease patients (the coronary being, as Oki puts it, the artery most likely to kill you), with baseline plaque imaging, a year of dosing, and a repeat scan; safety and PK continue, inflammatory biomarkers come on, and plaque volume change is the prize — for context, a 1% change in plaque volume is associated with roughly a 20% change in next-year risk of heart attack or stroke- The funding math and the platform — Cyclarity has raised $33M to date and needs roughly $45M more to run the Phase 2, with Phase 3 cardiovascular outcomes trials running into the hundreds of millions and likely requiring a pharma partner; beyond atherosclerosis, 7KC is elevated in NASH livers, in Alzheimer's brains, and in the retinal cells that die in age-related macular degeneration, and the underlying chemistry — designed binders that drag a specific toxic molecule out of the body — is meant to generalize into a pipeline against other accumulated damage species, the direct intellectual descendant of the SENS damage-repair programQuotes:"Atherosclerosis, or the plaque that builds up in your blood vessels in your arteries, is estimated to cause approximately 40% of all human death.""When [the macrophage] eats up too much oxidized cholesterol, it just accumulates it… And that's when you get this transition to these kind of monster blob cells called foam cells.""One molecule of our drug is supposed to bind one molecule of 7-ketocholesterol and then go away and never be seen again. You excrete both of them together.""A 1% change in plaque volume is associated with a 20% risk in the next year of your probability of having a heart attack or a stroke.""You pick one target at a time, you do it well, and you take it all the way to the clinic and hopefully prove that you can actually cure patients, help them get better, help their plaque shrink away, and prove that this approach can work."Links:Cyclarity Therapeutics: https://cyclarity.com

In this eye-opening episode, Dr. Scott Watier and Tommy Welling challenge the idea that the number on the scale is the best measure of metabolic progress, revealing why fasting is less about making the scale move and more about why it's moving. They break down the critical difference between being metabolically healthy at a higher weight versus metabolically at-risk at a normal weight, and why BMI alone misses the full picture. The hosts walk through five key markers to track alongside fasting — waist circumference, fasting glucose and insulin, triglyceride-to-HDL ratio, blood pressure, and visceral fat indicators — and explain how each one reflects real metabolic healing that the scale simply can't show. Listeners will come away understanding why consistency with fasting windows and simplified, protein-forward food choices accelerates cellular healing far more than chasing a daily weigh-in number. As a challenge this week, Dr. Scott and Tommy encourage listeners to measure their waist-to-height ratio, pull their most recent labs, and set one new scoreboard metric to track their true metabolic progress. ⁠Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Resources and Downloads: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠SLEEP GUIDE DIRECT DOWNLOAD⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Partner Links: Get your⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ FREE BOX OF LMNT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Get ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠25% off a Keto-Mojo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ blood glucose and ketone monitor (discount shown at checkout)! ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Click here!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Our Community: Let's continue the conversation. Click the link below to JOIN the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fasting For Life Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://www.levels.com/blog/what-can-weight-tell-you-about-your-metabolic-health

This week we talk about LDL, HDL, and cardiovascular issues.We also discuss one-time therapies, statins, and pharmaceutical economics.Recommended Book: Blood by Dr. Jen GunterTranscriptCholesterol is the most common type of what's called a sterol, which is a type of steroid, but also structurally technically an alcohol. But functionally, and classified by scientists, cholesterol is a lipid, which in this case is similar to a fat in all but how the body uses it. Cholesterol is the type of sterol most commonly found in animals—other types are found in plants and fungi—and its function, and this is where it varies from fats, which are used to store energy, is to basically help hold the cell membrane together, and it also serves as an intracellular messenger.Cholesterol is especially prevalent in the brain and spinal cord of animals, but it's found throughout their bodily tissues, as well, and again, it's vital for holding everything together and helping things communicate, in addition to being a precursor for vitamin D, steroid hormones, and bile.You want to have cholesterol, then, as without it you would be dead.Too much cholesterol in the blood, however, can also make you dead, especially when it's bound to what's called low-density lipoprotein, or LDL, as that contributes to cardiovascular disease like heart attacks and aneurysms, which can massively impact one's overall wellness and quality of life, and at extremes lead to the whole system shutting down as a consequence of heart attack, stroke, and the like.A lot of things can contribute to the development of cardiovascular disease, including habits like smoking, genetic predisposition, and the enthusiastic consumption of alcohol and unhealthy foods. But high blood cholesterol, of the LDL variety, is one of the top contributors, as these low-density clusters of lipoprotein can clog the pathways that blood takes throughout our bodies. Other, denser types of lipoproteins, HDLs, can clear it, like a heavier, denser substance pushing through clogs of less-dense materials that are gumming up a pipe, but LDL is at times accumulated as a result of consuming delicious but unhealthy foods, which are hard to avoid, and for some people the only consistently available and affordable foods; and for other people LDL accumulates as a result of their genetic predispositions—two things that are devilishly difficult to change.What I'd like to talk about today is a new type of therapy that may be very good news for people who struggle with the accumulation of LDL, and why this is being seen as very good news more broadly, at the scale of entire nations, as well.—Pharmaceutical company Eli Lilly is testing a new, experimental drug called VERVE-102 which is a one-time infusion that is currently administered over the course of about four hours, and once completed, it turns off a gene called PCSK9, which is responsible for making a protein that regulates cholesterol levels in humans.As I said, this drug is still being tested, so these are early results. But in a study of 35 people with high cholesterol levels, high levels of LDL or LDL-C, which is short for lipoprotein cholesterol, they found that this infusion, which again, is a one-time treatment, so get it once and then theoretically at least you never have to get anything done ever again, it reduced those LDL and LDL-C levels by as much as 62%, and that reduction was maintained a year and a half after the infusion; that's how far out they're retested so far, and the hope is that each retest will continue to show the same.On the strength of those very promising results, a Phase 2 study has been planned by the end of 2026, and the US Food and Drug Administration, the FDA, previously fast-tracked this existing study, because of the promise and potential this drug already demonstrated in early studies; all of which is considered to be very significant progress and possibility.To understand that significance, though, it's useful to know some health stats. And I'm going to focus on the US here, as that's where this drug is being developed, but many wealthy countries have similar stats, at least in terms of cardiovascular disease struggles.As of 2024, which is the last year we had good, cohesive data on this in the US, it was estimated that about 11-12% of the US adult population has high cholesterol levels. This typically doesn't come with any symptoms, but it can contribute a higher risk for all those cardiovascular diseases, including heart attack and stroke. A further 86 million US adults have borderline or elevated cholesterol levels, which can easily tip higher, but also, even in that existing, elevated state, contribute to negative cardiovascular outcomes.There are treatments for high cholesterol, the most common of category of which are called statins, which reduce the production of LDL by inhibiting an enzyme that produces cholesterol in the body.Unfortunately, these drugs do come with some usually minor side effects, which can cause patients to stop using them, and they have to be taken daily, ideally at the same time each day. That necessity for consistency leads to a lot of incorrect or incomplete usage, which reduces the effectiveness of these drugs. But it's also estimated that only about 54.5% of US adults who would benefit from statins are currently taking one—so that's people who could benefit and who have it prescribed, and then within that number are all the people who are taking this drug incorrectly or incompletely, reducing the effectiveness. So a relatively small number of people who should probably be on these things are getting the full benefit they offer because of the nature of the drug.And that's not great, because in the US alone, heart disease is the leading cause of death for pretty much every adult demographic; men, women, people of most racial and ethnic and economic groups, you name it, heart disease is the biggest threat to their lives.One US citizen dies every 34 seconds of some kind of cardiovascular condition, and as of 2023, 1 in every 3 deaths in the US was caused by the same, adding up to just over 919,000 people that year.Between 2021 and 2022, alone, the cost of services and medications related to heart disease added up to more than $168 billion; again, that's just in that period, and just in the US.And once more, these are ailments that are caused or heavily influenced by high levels of cholesterol, which are themselves amplified by common lifestyle choices, environmental factors that are hard for many people to avoid, and just by raw, dumb luck because of genetics.This treatment category, then, is being seen as a pretty big deal because a one-time infusion means those who receive it don't have to remember to take a pill every day at the same time, and won't experience those statin-based side-effects.It also means that people who are currently costing the medical system a bunch of money each year, because they need treatments for all the issues they suffer as a result of high cholesterol, will suddenly cost the system a lot less money, for treatments and medications. Not for nothing, their health and quality of life will likely improve as well. So in addition to having better, healthier outcomes personally, their cost to healthcare systems will drop.Eli Lilly's drug isn't the only one currently working its way through clinical trials, either.Amgen is working on a similar treatment, and Novartis and Ionis Pharmaceuticals have drugs that are even further along in the process, their medicines that cut heart attacks, strokes, and cardiovascular deaths could be approved by the FDA as soon as next year.There are a lot of caveats worth noting here, including that the science is still out as to whether this approach, silencing proteins that lead to the creation of more LDL and a similar substance called Lp(a)—which is more dangerous because it's stickier and thus more likely to get stuck in important blood pathways, and it's also more likely to be caused by genetics than lifestyle—the word is still out on whether reducing these things in the body actually reduces hearth attacks and stroke.Some people have had this particular risk variable dramatically reduced, but have still suffered from cardiovascular events, which raises the question of whether this path is the right one to take in trying to reduce this category of health issues; the correlation between LDL and heart attacks and strokes might not be a clear-cut as long assumed.There's also the issue of price. Drug-makers are economically incentivized to sell treatments over cures, because that means they can continue selling their product over time, potentially for the life of the patient, and a cure, in contrast, is a one-time hit that in theory should alleviate the need for future treatment.There's a chance, then, that the drug-makers will decide they need to make these one-hit treatments really, really expensive in order to make their R&D dollars back and to make the kinds of profits their investors expect from them. That could then reduce the potential audience for these treatments, even if they are effective, and could further slow their deployment and future research in this space.If these trials continue to go well, though, there's a good chance that this combination of similar but distinct treatment types will provide a more sustainable alternative to current options, and that, like the recent bogglingly rapid and widespread deployment of GLP-1 treatments for all sorts of issues, could lead to a new paradigm in this facet of the medical world.Show Noteshttps://en.wikipedia.org/wiki/Cholesterolhttps://en.wikipedia.org/wiki/Cardiovascular_diseasehttps://en.wikipedia.org/wiki/High_cholesterolhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10982736/https://www.cdc.gov/heart-disease/data-research/facts-stats/index.htmlhttps://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1https://www.ama-assn.org/public-health/chronic-diseases/what-doctors-want-patients-know-about-high-cholesterolhttps://en.wikipedia.org/wiki/Statinhttps://pubmed.ncbi.nlm.nih.gov/42187087/https://abcnews.com/GMA/Wellness/new-drug-game-changer-people-high-cholesterol/story This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe

Could you have metabolic dysfunction even at a normal weight?This episode challenges everything we've been taught about weight and health. Dr. Cooper reveals that up to 25% of normal-weight people have metabolic syndrome, yet they're rarely screened because doctors assume they're healthy based on appearance alone.KEY TAKEAWAYSWeight and metabolic health are not the same thing - you can be metabolically unhealthy at any sizeNormal weight people with metabolic dysfunction are often overlooked and undertreated by healthcare providersKey screening tests include fasting glucose, insulin, HbA1c, triglycerides, HDL cholesterol, blood pressure, and inflammatory markers like HSCRPMetabolic dysfunction can start in your 20s and take decades to develop into serious diseaseBoth normal weight and higher weight patients face bias - normal weight people aren't screened enough, while higher weight people have everything blamed on their weightEarly screening and treatment can prevent catastrophic health outcomes later in lifeThe liver plays a crucial role in metabolism and can become insulin resistant regardless of body weightNOTABLE QUOTE"You cannot tell anything about someone's health from their outside, what they look like or what, even what they're doing necessarily, but definitely not their body size. So you can be healthy or unhealthy at any size body, and I think that's what's overlooked quite a bit." — Dr. Emily CooperLinks & ResourcesPodcast Home: fatsciencepodcast.comCooper Center for Metabolism: coopermetabolic.comResources from Dr. Cooper: coopermetabolic.com/resourcesJoin Our Community: patreon.com/cw/FatSciencePodcastSubmit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comAppendix: Key ReferencesPrimary literature supporting this episode•       Wang et al. Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes. Journal of Clinical Endocrinology & Metabolism, 2023.•       Review: Beyond BMI — Rethinking Obesity Metrics and Cardiovascular Risk in the Era of Precision Medicine. Journal of Clinical Medicine, December 2025.•       Korean meta-analyses on metabolic dysfunction phenotypes and cardiometabolic risk, Cardiovascular and Metabolic Sciences Journal review, 2024.•       Frontiers in Nutrition, January 2026. Associations of metabolic heterogeneity with the progression of cardiometabolic multimorbidity.•       International Journal of Obesity, September 2025. Cardiovascular risk factors associated with metabolic health phenotypes.Mechanism references•       MASLD — metabolic dysfunction-associated steatotic liver disease — nomenclature and clinical framework. AASLD/EASL consensus, 2023.•       Insulin signaling, adipose tissue dysfunction, and ectopic fat deposition — reviews on the upstream-downstream relationship.•       Epicardial adipose tissue and cardiovascular dysfunction — Frontiers in Cardiovascular Medicine, January 2026.Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Matt: Hi Dr Cabral, I'm constantly trying to improve my sleep but can rarely ever get more than 6 to 6 1/2 hours consistently. If I go to bed earlier, I wake up earlier ready to go. Right now I'm taking 2g of taurine, balanced zinc, 500mg magnesium, 100mg theanine, 50mg Apagenin and 3g of glycine. I have no problem falling asleep but consistently wake up around 3-4am. I recently added some Inositol to help get back to sleep but I can't really remember the last time I went to sleep and woke up the next morning by my alarm clock. Just to note, I'm 45 with 3 kids that also like to pop in our room in the middle of the night. Any tips to help get that 7-8 hours I need?       Tricia: Hello Dr C! I'm 57 and I tested my estrogen and progesterone. I'm of course estrogen dominant. I started taking your progesterone support and gosh it is amazing! My sleep has gotten even better! My question is do you think I should take the estrogen supplement too to help balance the two? Are these usually lifetime supplements for post menopausal women? Thanks     Kevin: Just received my annual labs back for annual physical and total Cholesterol is 299, Triglycerides 70, HDL 105, LDL 180, ratio 3.8, and LDL Direct at 182. I have Hashimoto disease, candida for past couple of years and mycotoxins from mold exposure. I cant afford to move out of house so I'm still exposed. I had a functional doctor but can no longer afford the out of pocket expenses. I was on cholestramine powder along with binders but stopped doing them last year because not helping. I'm really worried about having stroke or heart attack. I don't know where to start anymore and been told without moving nothings going to work. What do you recommend I do.? I plan on purchasing Proteolytic Enzymes with Nattokinase to hopefully reduce plaque. What tests do you think would be best for me?       Sienna: Hi Dr. Cabral - hoping you can help! In a country where FM labs aren't an option + entering into mid-40's, surrounded by Perimenopause "fear". I have done your hormone HRA + apart from feeling like I get TRIGGERED a lot easier, I don't have more of the common symptoms (ie night sweats). My cycle the last 2 months was slightly longer but don't want to over think it. I am wondering if there are bloods that can help outline where we are in terms of our hormones (I know saliva is preferable)... I really want to support my hormones, and know you say we can do this naturally well into later life ie 60's! I know estrogen declines + ED is common - would appreciate markers to look at, ranges + if your wife couldn't test what you'd recommend for her :) Thank you for ALL you do! Sienna       Rianna: Hi Dr. Cabral! Sleep it's an area I am REALLY focused on supporting - we know when we are tired everything is harder ;-) & I am all about energy as I move towards my mid-40's.. I track my sleep on Garmin + know you mention Deep Sleep (90 mins) + Rem Sleep (2+ hours) as ideals, but I am no where near there consistently. The only time I get quite close is during my detox. My HRV has improved considerably (almost doubled) since Jan(through substantially reducing alcohol intake + focusing on sleep hygiene). I average on 7 - 7.5 hours sleep, mostly right through or brief wake, + mostly feel great/rested. My REM sleep this morning was 0 minutes (??) - is that reall even possible? 80 mins deep, 6.5 hrs"light" - how much attention would you give it if you feel recharged? Tips? Thx for all you do!     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3782 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

In this episode the guys break down the four biggest fitness traps of 2026 — over-reliance on wearables and tech, the GLP-1 shortcut and muscle loss crisis, chasing longevity fads over basics, and aesthetics over everything. They also get into the alien.gov website reveal (spoiler: not what anyone expected), the black market GLP-1 side hustle spreading through social circles, a new study showing resistance training beats cardio for fat loss head to head, and Doug's 30-day Dose liver enzyme experiment update. Then they coach live callers submitted through mplivecaller.com — Aidan from Kansas on lingering strength and nerve issues after mono, Jamie from Oklahoma on rebuilding her relationship with food and training after anorexia and overtraining, and Caleb from Pennsylvania who shares an inspiring 18-month reverse diet success story before getting help with chronic forearm pain. MAPS Summer Sale — https://mapsfitnessproducts.com Code: SUMMER40 — 40% off everything (programs, bundles, mods & guides) — June 1–14 only SPONSORS Vuori — https://vuoriclothing.com/mindpump 20% off first order — no code needed, automatically applied Dose (liver & cholesterol support) — https://dosedaily.co/MINDPUMP Code: MINDPUMP — 25% off first month subscription. Clinically backed, all-natural liquid supplement. Supports liver enzymes, LDL, HDL and skin health. Fatty15 (C15 essential fatty acid) — https://fatty15.com/MINDPUMP Code: MINDPUMP — additional 15% off the 90-day Starter Kit subscription. C15 has been shown to have 3x more cellular benefits than omega-3. LINKS Submit a live caller question: https://mplivecaller.com  Mind Pump Store: https://mindpumpstore.com  Maps Fitness Products: https://mapsfitnessproducts.com  Instagram: @mindpumpmedia 0:00 - Intro 2:12 - Fitness trap #1: Over-reliance on wearables and tech — when data becomes a stressor 8:21 - Fitness trap #2: GLP-1 and the muscle loss crisis — what nobody is telling you 16:36 - Fitness trap #3: Chasing longevity fads while ignoring the basics 20:56 - Fitness trap #4: Aesthetics over everything — why chasing the look kills the look 33:23 - Vuori — the random guy at the park who wouldn't stop complimenting Sal's joggers 44:57 - Resistance training vs. cardio for fat loss — new head to head study 47:57 - Dose liver supplement — skin benefits and Doug's 30-day cholesterol experiment 55:43 - Alien.gov — the government website reveal nobody saw coming 59:33 - Caller: Aidan (Kansas) — college swimmer, post-mono nerve issues, lost 100lbs on bench 1:13:13 - Caller: Jamie (Oklahoma) — anorexia history, overtraining, inner thigh pain, gets a coach 1:27:24 - Caller: Caleb (Pennsylvania) — 18-month reverse diet success story, now dealing with forearm pain  

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

In this fascinating episode of the Optimal Protein Podcast, Vanessa Spina is joined by Dr. Fernando Naclerio, Professor in Strength Training and Sports Nutrition at the University of Greenwich and Centre Lead for the Centre for Exercise Activity and Rehabilitation. Vanessa and Dr. Naclerio dive into a brand new meta-analysis comparing higher-carb and lower-carb diets when calories and protein are matched. While both approaches improved body composition, the low-carb diets produced greater reductions in fat mass, fasting glucose, fasting insulin, and triglycerides, along with increases in HDL. This conversation explores why not all weight loss is fat loss — and why consuming too many carbohydrates during a calorie deficit may, in certain conditions, shift the body toward burning more lean mass instead of body fat. They also discuss how to structure protein, carbohydrates, and fats for better body composition, why carbohydrate tolerance depends on activity level, the importance of resistance training, keto adaptation, meal timing, fasting, protein distribution, and why protecting muscle should be the priority during fat loss. The PSMF Library is officially live

This podcast is listener-supported. To receive new posts and support my work, consider becoming a free or paid subscriber.When we think about staying healthy, we naturally focus on daily habits like a balanced diet, exercise, and stress management. But there is a critical, often overlooked window into our body's internal workings that tells us exactly how those efforts are paying off: regular blood work.In this episode, I dive deep into the world of biomarkers and explore why tracking these numbers is the most powerful tool we have for detecting potential health issues before they ever show physical symptoms.I break down what is actually being measured in standard lipid and metabolic panels, debunk common misconceptions about “optimal” cholesterol levels, and look at the real-life numbers from my own recent blood work for reference. Whether you are curious about how a plant-based diet impacts your numbers or want to know which hidden tests you need to request at your next checkup, this episode serves as your comprehensive guide to owning your health.CAMBODIA 2027: Join me on an unforgettable journey from the breathtaking temples of Angkor to the vibrant streets of Phnom Penh. Join us for Culture, Cuisine & Conservation. Enter JOYFULVEGAN when booking to redeem the special offer of a one-on-one or private cooking class with me.In this episode we cover:* Why serious cardiovascular issues can develop silently without physical symptoms, and how early screening acts as a lifesaver* A simple “garbage truck” analogy to easily understand the differing roles of LDL and HDL cholesterol in your bloodstream* What clinical data reveals about the ideal total cholesterol threshold for eliminating heart attack risk* The chemical difference between animal-based saturated fats and plant-based options like coconut oil* The biological differences between Type 1 and Type 2 diabetes, and how to prevent insulin resistance naturally* How to meet your iron requirements effortlessly on a plant-based diet without unnecessary and dangerous supplementation* Key vitamins, minerals, and inflammation markers that are omitted from standard panels but are vital to request* A look at my own recent blood numbers and a personal story regarding hair thinning, perimenopause, zinc, and B12.

Equip Foods grass-fed beef protein (20% off with Ben's link):  https://bit.ly/3RKCzhW — use code BENAZADI Pre-order Keto Flex Revised and get free bonuses: https://bit.ly/4wKG1sM    Ben Azadi spent 90 straight days eating nothing but beef, eggs, butter, salt, and organ meat. No vegetables, no fruit, no fiber, no carbs. Then he tested everything. His cholesterol numbers would have sent most doctors into a panic. His total cholesterol hit 434. His LDL hit 350. But when one of the world's top heart surgeons reviewed the full panel, the verdict was clear: his cardiovascular risk had actually improved. Then the gut results came in. After 90 days of zero plants and zero fiber, his gut microbiome diversity went up. Not down. Up. In this episode, Ben walks through everything: the adaptation period, the body composition changes, the full blood work breakdown with board-certified cardiothoracic surgeon Dr. Philip Ovadia, the gut microbiome reveal with Dr. Will DiPaolo and Dr. Daniel Pompa, and what the science actually says about cholesterol, red meat, and the human body. If you've ever been told that saturated fat will kill you, that LDL is the enemy, or that you need fiber to have a healthy gut, this episode will make you question all of it. Key takeaways: Lost 16 pounds and 6% body fat in 60 days Heart rate variability, sleep quality, and glucose all improved Triglyceride-to-HDL ratio hit 1.0, a marker of near-zero insulin resistance Gut diversity, keystone bacteria, and core bacteria all increased on zero plants LDL on its own is one of the worst predictors of actual cardiovascular risk Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

Are your daily habits negatively impacting your hormones and your overall health? And when it comes to hormones, are you focusing on only your sex hormones? It turns out other hormones are running the show! This episode breaks down common hormone dealbreakers and practical steps you can take to avoid them and reclaim your health.On this episode of Salad with a Side of Fries, host Jenn Trepeck is joined by Robin Nielsen, board-certified integrative nutritionist and founder of Natural Hormone Solution, to unpack the hidden hormone dealbreakers quietly sabotaging your health. From the real role of cortisol rhythm to the truth about cholesterol and sex hormones, xenoestrogens in your face cream, and why your to-do list is wrecking your endocrine system, this conversation is a masterclass in natural hormone balance for women at every stage of life.What You Will Learn in This Episode:✅ Why cortisol and insulin are your two most important hormones and how their dysregulation drives symptoms that are often misread as perimenopause or aging.✅ How environmental xenoestrogens found in face creams, shampoos, and household cleaners silently disrupt your estrogen balance and what to do about it.✅ The critical connection between eating for hormone balance, meal timing, and why skipping breakfast and over-exercising are two of the most damaging habits for women's hormonal health.✅ How cholesterol actually serves as the building block for all your steroid hormones, and why lowering it too aggressively may be making your symptoms worse.The Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Jenn introduces Robin Nielsen, founder of Natural Hormone Solution and integrative nutritionist04:57 Robin shares her personal story: decades of weight gain, cystic acne, and digestive health issues09:18 Why common symptoms are not normal: hormone imbalance signs you may be ignoring11:27 Your sex hormones aren't the only ones linked to your overall health and wellness15:41 Cortisol rhythm explained: how your brain responds to daily stress and excess cortisol21:14 Hormone dealbreaker one: how negative thoughts and low serotonin levels disrupt cortisol23:24 Hormone dealbreaker two: xenoestrogens, environmental toxins, and harmful body care products27:47 The importance of eating breakfast and the benefits of walking33:19 Discussion of cholesterol levels and balancing HDL and LDL numbers38:12 The surprising hormone dealbreaker hiding in plain sight: your to-do list and nervous system healthKEY TAKEAWAYS:

Eat this every single day to help prevent clogged arteries and support heart health. Focus on heart attack prevention by addressing the real cause of artery plaque buildup in the first place.

Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) testedWhat a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person datasetWhy the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat aloneThe simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular riskBy the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.Thank you to our sponsors:OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYONBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Kevin Maki at:Midwest Biomedical Research: https://www.mbclinicalresearch.com/ LinkedIn: / kevin-c-maki-phd-497ba34 Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction00:31 - Dr. Kevin Maki and the National Lipid Association01:04 - New dietary guidelines and the LDL confusion02:04 - What raises and lowers LDL cholesterol03:51 - Cholesterol levels from birth through puberty05:11 - The lipid panel kids should get before age 1106:42 - Lp(a): the test only 2% of people get08:18 - ApoB and the three risky particle types11:35 - Do we have evidence for "lower is better"?14:09 - The FLASH-GLICK risk factor framework17:10 - The 10% saturated fat guideline explained19:36 - Many dietary patterns can be healthy24:50 - Beef vs. chicken: identical LDL results27:10 - The balance of fatty acids that matters29:24 - Olive oil vs. corn oil feeding study31:00 - Lower for longer: 40-year risk reduction34:15 - Genetic cholesterol disorders and risk40:33 - The omega-3 index and why it matters49:10 - Are seed oils really driving inflammation?53:11 - How seed oils are processed and refined1:07:48 - Inherited beliefs and outdated nutrition science1:08:54 - Butter vs. cheese and high-fat dairy surprises1:14:48 - Exercise effects on HDL and triglycerides1:21:20 - The ABCs of reducing cardiovascular riskIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Jacquie: My 65-year-old mom was diagnosed with osteoporosis via DEXA (spine -2, hip -3). She's had a hip replacement & later suffered a fall that fractured her femur near the implant. Listened to your other podcasts & I wonder are there cases where the body can't rebuild bone without conventional intervention? Is there research on this? Her doctor recommended injections, saying vitamins alone won't restore bone to the needed level—how valid is that? She does quarterly detoxes & takes DNS, omega3s, vitamin D/K2 drops, & CalMag. She plans to add Daily Bone Support, reduce inflammatory foods & alcohol & increase weight-bearing exercise as able. Testing suggests she follow a limited CBO protocol. Not giving medical advice, what would you do/look into if this was your family member? Thank you!      Lynne: I don't see eggs on the food list. Is it ok to eat eggs after the detox? If so, how often. I can get fresh eggs from a local farm and I love them.      Drew: Dr Cabral, I heard on another podcast (Rhonda Patrick) there was a research study that showed high speed blenders like Blentech and Vitamix can expose you to microplastic due to ingredients hitting the side of the plastic container. this is increased if using frozen ingredients such as blueberries or ice. i have been making a smoothie for breakfast for almost ten years. i would love to get your take on this. if this is true? should my highspeed blender be replaced (Blentech does not have a Stainless steel or glass container option). should someone who may have been exposed take any extra steps to detox? thank you so much     Lisa: I seen your post on berberine and was wondering when is the best time of day to take it? Should I take it with every meal or just once a day? Should I take it before eating or after? You said it can help with fat burning even while sleeping so should I take before bed? Should I avoid taking it with my pre workout meal? Thank you in advance Lisa      Jill: Hello, thank you for your informative and educational emails. Looking for the best applications of using Proteolytic Enzymes vs. Niacin for lowering cholesterol and triglycerides and increasing HDL if calcium score is zero. What would the recommended doses be of each?    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3754 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!