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Most people think heart disease is caused by cholesterol—but the real problem is hidden in the foods you eat every day. In this episode, Ben Azadi reveals seven artery-healing superfoods that naturally raise HDL, lower triglycerides, and unclog your arteries—without statins or surgery. You'll also learn the “healthy” food combos that are secretly destroying your heart, and the simple daily habits that boost nitric oxide, reduce inflammation, and protect your cardiovascular system for life. Resources:
Send us a textDr. Josh Wageman is a Clinical Lipid Specialist with multiple doctoral degrees who formerly practiced in Endocrinology. His PhD work focused on cholesterol disturbances in Alzheimer's Disease, and although he also has a Doctorate in Physical Therapy, he is best known for his role in teaching lipid physiology.He serves as an adjunct professor at several medical programs and his goal is to help you, whoever you are, NOT have heart attacks, strokes, and dementia by explaining complicated biochemical concepts in a relatable way!Employing a smorgasbord of metaphors, pictures, and catchphrases, his latest book The Home Security System and the Lipid Neighborhood serves as a valuable reference for clinicians and non-clinicians alike, bringing refreshing relatability to complex biochemical topics. Through a lipid-lens, you'll learn, laugh, and love your way through its pages…and in the end, you'll undoubtedly add “life to your years!”Dr. Josh Wageman is active in Youth Ministries at Heritage Bible Church in Boise, Idaho, and resides there with his family. He also enjoys Crossfit, basketball, Ultimate Frisbee, and all sports that don't involve skates.Find Dr. Wageman at-Amazon- The Home Security System and the Lipid Neighborhood IG- @wagemanjoshLK- @Josh WagemanFind Boundless Body at- myboundlessbody.com Book a session with us here!
Beating Cancer Daily with Saranne Rothberg ~ Stage IV Cancer Survivor
Today on Beating Cancer Daily, Saranne welcomes back functional medicine expert Jacqui Bryan for an in-depth look at berberine—a natural compound generating major buzz as “Nature's Ozempic” on platforms like TikTok. With excitement high from both Saranne and Jacqui, the conversation explores berberine's traditional use in Chinese and Ayurvedic medicine, its modern reputation for supporting blood sugar control, heart health, weight management, cognitive function, and even potential anti-cancer qualities. Saranne highlights the supplement's growing popularity among those seeking natural alternatives to pharmaceuticals and underscores the importance of professional guidance before starting any supplement, especially for those navigating cancer, like survivors who are wary of synthetic drugs or those living with conditions such as Stage IV cancer.Jacqui Bryan is a certified nutrition specialist, whole health educator, certified health coach, and registered nurse. Her multidisciplinary, functional medicine background empowers others to take charge of their health through evidence-based, holistic approaches. Jacqui is passionate about translating the latest research into practical wellness strategies and is known for her ability to make complex topics both accessible and actionable for those managing chronic illness or seeking better overall health.“I love it when we can find things in nature that can improve our health, which I think is a lot of what we've been doing with this podcast.” ~Jacqui BryanToday on Beating Cancer Daily:· Berberine is a natural plant compound with a long history in traditional medicine, now being explored for its impacts on metabolism, blood sugar, and even cancer. · The supplement is often compared to pharmaceuticals like Ozempic and metformin, generating popularity as a “natural” alternative, especially for those hesitant to use synthetic drugs. · Berberine's most studied effects include blood sugar regulation, enhancing insulin sensitivity, and supporting energy production at a cellular level. · Its role in gut health is significant, potentially supporting microbiome diversity, improving digestion, and providing relief for conditions such as SIBO. · Potential heart health benefits include lowering LDL (bad) cholesterol and triglycerides, and possibly increasing HDL cholesterol, though results may be stronger for women. · Proper use—including dosing, timing (typically before meals), and supplement quality, should always be discussed with a healthcare provider, given potential drug interactions and contraindications. · Berberine is not suitable for everyone, especially those who are pregnant, breastfeeding, on statins, or already using GLP-1 medications. · Reevaluating supplement routines regularly and coordinating with medical teams is critical to ensure safety, efficacy, and the avoidance of unnecessary or harmful combinations. 2025 People's Choice Podcast Awards Finalist Ranked the Top 5 Best Cancer Podcasts by CancerCare News in 2024 & 2025, and #1 Rated Cancer Survivor Podcast by FeedSpot in 2024 Beating Cancer Daily is listened to in over 130 countries across 7 continents and features over 390 original daily episodes hosted by Stage IV survivor Saranne Rothberg. To learn more about Host Saranne Rothberg and The ComedyCures Foundation:https://www.comedycures.org/ To write to Saranne or a guest:https://www.comedycures.org/contact-8 To record a message to Saranne or a guest:https://www.speakpipe.com/BCD_Comments_Suggestions To sign up for the free Health Builder Series live on Zoom with Saranne and Jacqui, go to The ComedyCures Foundation's homepage:https://www.comedycures.org/ Please support the creation of more original episodes of Beating Cancer Daily and other free ComedyCures Foundation programs with a tax-deductible contribution:http://bit.ly/ComedyCuresDonate THANK YOU! Please tell a friend whom we may help, and please support us with a beautiful review. Have a blessed day! Saranne
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Suzanne: Thank you for your time in advance. In late 2021, my husband was diagnosed with Stage IV prostate cancer. He underwent six rounds of chemo along with Eligard injections. After his last scans, whole body and bone, we were told the cancer is "stabilized". He is currently on 300 mg of Nubeqa 2x a day (down from 4 x because I asked about it) and Lupron injections every 3 months. We have consciously changed our diet (no added sugar, no alcohol, no processed foods) and he is doing pretty well, although, he does fatigue and sweat easily. My question is whether you believe that taking a couple of your home tests would be beneficial for him? I worry about these powerful drugs he is being given and have noticed a reluctance from the doctor about reducing his drugs any further. Thank you again! Sheena: Hi Dr C! Hope you and your team are well. I recently went for blood work. I fasted for 14 hours and was wondering what your thoughts are specifically regarding my Lipid Panel and Iron Panel. My triglycerides is 1.83, Total 4.05, HDL 1.72 and LDL 1.63 (all mmol/L). For iron my levels are 37 umol/L, iron binding 0.70 umol/L, and ferritin 44 ugL. My Dr says she's concerned with my triglycerides. How can I lower it? And shes concerned with my ferritin and iron levels so shes sending me for a Hemochromatosis blood test to see why the levels are off. (My fasting glucose is 4.9, hbA1c is 5.2, TSH is 1.04 and Auto CBC is 3.8). Would love your thoughts and any food and supplementation recommendations would be appreciated! Love you and all the best to everyone on their health journey! Madhia: Hello My Dr is giving me a hard time to prescribe MRI for my breast exam. Do you have any Dr you can recommend that would help me in greater Los Angeles area? Margie: My son, who is 46 years old has had Alpha-Gal for approximately 10 years. Now his wife has also been diagnosed with it. I am aware it is caused by a tick bite. He constantly has mass cell inflammation including breathing and allergy issues. Could you please explain specifically how this disease affects the body's immune system and which of your protocols should be used to bring the body back into balance. Will that particular protocol bring the body back into balance enough so that it will relieve the mass cell inflammation and they can return to eating mammal meat? Jackie: Hi Dr. Cabral thank you for all that you do. You have made a tremendous impact in my and my clients lives. My husband has just finally been diagnosed after 10 years of misdiagnosis with neurogenic TOS. We have a great rehab team working on the biomechanics and we are exploring Big 5 root causes. I was wondering what natural pain management methods you would recommend during the process pain is 10/10 and conventional medicines wants to basically kill the nerve or put him on Lyrica which neither are an option for us. We are exploring accupuncture, grounding and adrenal sooth/inflammasoothe/cbd protocol. Any other alternative inflammation reduction techniques or devices you would recommend? Could you do a podcast on natural pain management strategies for people with chronic pain? Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3495 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
We've been told to run, bike, and diet our way to lower cholesterol, but what if the real game changer is strength training? In this episode, Amy Hudson and Dr. James Fisher unpack the science behind resistance training and why it might be the best exercise to lower cholesterol. They explore what research actually says about lifting weights, LDL reduction, and long-term heart health — and why it might be time to rethink your approach to fitness. Dr. Fisher defines cholesterol--a waxy, hormone-like substance that your body produces and regulates on its own. While it often gets labeled as “bad,” it plays vital roles in hormone production and cell health. Dr. Fisher highlights that what we call “cholesterol” is actually carried in the blood by lipoproteins. LDL (low-density lipoproteins) can clog arteries, while HDL (high-density lipoproteins) helps remove excess cholesterol from the bloodstream. Amy breaks down how LDL is considered the “bad” cholesterol because it can harden and narrow artery walls. In contrast, HDL acts like a cleanup crew, carrying unused cholesterol back to the liver to be broken down or reused. Dr. Fisher discusses a meta-analysis of 69 studies involving over 2,000 people that showed consistent benefits from strength training. Participants saw reductions in total cholesterol, LDL, and triglycerides, along with increases in HDL and adiponectin levels. Amy points out that participants who strength trained saw an average drop in total cholesterol of about 8.5 mg/dL. That's a significant improvement — and it didn't require any changes to diet. Dr. Fisher emphasizes that these changes happened independently of calorie restriction or food tracking. Amy and Dr. Fisher explain that the cholesterol-lowering effects of strength training were consistent, whether people trained once, twice, or three times a week. Frequency mattered less than simply doing the work. Dr. Fisher breaks down one individual study in the meta-analysis that used six months of full-body strength training. The results showed reduced fat mass, decreased LDL, and increased HDL — all strong markers of better metabolic health. The cholesterol improvements were not just a side effect of losing weight or fat. The act of strength training alone led to these changes, regardless of body composition. Amy challenges the common belief that cholesterol is only affected by food or medication. The data shows strength training is a powerful, underused tool to shift your numbers naturally. Learn how strength training offers more than just physical benefits — it's also a stress reliever. Pushing through a high-effort workout helps unload mental baggage, too. Amy and Dr. Fisher explore how dietary choices still matter — and discuss how eggs, red meat, and even wine influence cholesterol levels. They encourage variety and moderation over strict elimination. Dr. Fisher advises people to “eat the rainbow,” meaning to include colorful, nutrient-dense foods in your diet. He cautions that many Western diets are too dominated by fried and processed foods — and lack the diversity our bodies need. Amy and Dr. Fisher conclude that combining smart dietary choices with consistent strength training may be one of the most effective ways to lower cholesterol naturally. Mentioned in This Episode: The Exercise Coach - Get 2 Free Sessions! Submit your questions at StrengthChangesEverything.com Previous episode - Why Most People Fail in the Gym (And How Supervision With a Personal Trainer Can Help) This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content.
Episode Summary In this powerful solo episode, Jason explores why self-compassion isn't just nice—it's literally the fastest path to transformation. He dismantles the toxic myth of "I should have known better" and reveals why judging your past choices keeps you stuck in old patterns. This episode offers both scientific backing and spiritual wisdom on how accepting that you've always done your best with what you had can free up massive energy for creating your future. Key Takeaways The Myth of "Should Have Known Better" The spiritual poison: When you say "I should have known better," you're arguing with reality The truth: You made the best decision you could with the level of consciousness you had at that time Reality check: You can't upgrade your past with your current software The Science of Self-Compassion Dr. Kristin Neff's research: Self-compassion leads to higher standards and better performance than self-criticism Neurological impact: Self-judgment activates threat detection and shuts down the prefrontal cortex (learning center) Self-compassion benefits: Activates the caregiving system, floods brain with oxytocin, releases neuroplasticity for transformation The Spiritual Dimension Universal law: Consciousness evolves through experience, not judgment Buddhist concept: Beginner's mind—every moment is a fresh start Soul purpose: Your soul didn't incarnate to live a perfect life, but a full life Wisdom creation: Regret is just wisdom trying to be born Generational Healing Breaking chains: When you practice self-compassion, you heal an entire lineage Ancestral patterns: Most patterns you judge yourself for were inherited Radical service: Self-compassion is the most radical act of service you can perform Practical Application: The Three-Step Process Step 1: Catch Yourself in Self-Judgment Ask for help recognizing when you're "shoulding" on yourself Step 2: Ask Three Self-Aware Questions What did I know then? What was my capacity then? What was I dealing with then? Step 3: Use the Sacred Phrase "I did what I knew how to do" Put this on your mirror Carry it in your pocket Say it every time you catch self-judgment Bonus Practice: Get Curious Instead of Judgmental Replace "Why did I do that?" with: "What was this choice trying to teach me?" "What was my soul learning through that experience?" Powerful Quotes from This Episode "You can't know what you don't know until you know it." "Self-judgment is just ego trying to time travel." "You can't punish your past self into being better. You can only love your present self into growing." "The voice that heals you is never the same voice that hurts you." "You can't heal what you judge." "You can only choose victim or victor, but you can't choose both." "Your past doesn't define you, it refines you." Scientific & Spiritual References Dr. Kristin Neff: Self-compassion research and psychological safety Buddhist wisdom: Beginner's mind concept New Testament teaching: "Judge not lest you be judged" Rudolf Steiner: "We're all angels in training" 24-Hour Challenge Every time you catch yourself in self-judgment: Pause and breathe Say: "I did what I knew how to do. I am learning and growing. I'm exactly where I need to be." Connect with HDL Podcast If this episode gave you permission to stop being your own worst enemy, share it with someone who needs to hear it. Remember: you did what you knew how to do—now you know more, now you can do more, but always with compassion for the journey. Listener Action Items Write "I did what I knew how to do" on your mirror Practice the three self-aware questions when judgment arises Share this episode with someone who's being hard on themselves Join the HDL community for deeper discussions on self-compassion This episode aligns with HDL Podcast's mission to provide grounded spirituality for the modern seeker—offering both open-hearted curiosity and critical discernment on the journey of conscious living.
This is a hybrid heart disease risk factor post of a podcast with Prof Bruce Lanphear on lead and a piece I was asked to write for the Washington Post on risk factors for heart disease.First, the podcast. You may have thought the problem with lead exposure was circumscribed to children, but it's a much bigger issue than that. I'll concentrate on the exposure risk to adults in this interview, including the lead-estrogen hypothesis. Bruce has been working on the subject of lead exposure for more than 30 years. Let me emphasize that the problem is not going away, as highlighted in a recent New England Journal of Medicine piece on lead contamination in Milwaukee schools, “The Latest Episode in an Ongoing Toxic Pandemic.”Transcript with links to the audio and citationsEric Topol (00:05):Well, hello. This is Eric Topol with Ground Truths, and I'm very delighted to welcome Professor Bruce Lanphear from Simon Fraser University in British Columbia for a very interesting topic, and that's about lead exposure. We tend to think about lead poisoning with the Flint, Michigan, but there's a lot more to this story. So welcome, Bruce.Bruce Lanphear (00:32):Thank you, Eric. It's great to be here.Eric Topol (00:33):Yeah. So you had a New England Journal of Medicine (NEJM) Review in October last year, which was probably a wake up to me, and I'm sure to many others. We'll link to that, where you reviewed the whole topic, the title is called Lead Poisoning. But of course it's not just about a big dose, but rather chronic exposure. So maybe you could give us a bit of an overview of that review that you wrote for NEJM.Bruce Lanphear (01:05):Yeah, so we really focused on the things where we feel like there's a definitive link. Things like lead and diminished IQ in children, lead and coronary heart disease, lead and chronic renal disease. As you mentioned, we've typically thought of lead as sort of the overt lead poisoning where somebody becomes acutely ill. But over the past century what we've learned is that lead is one of those toxic chemicals where it's the chronic wear and tear on our bodies that catches up and it's at the root of many of these chronic diseases that are causing problems today.Eric Topol (01:43):Yeah, it's pretty striking. The one that grabbed me and kind of almost fell out of my chair was that in 2019 when I guess the most recent data there is 5.5 million cardiovascular deaths ascribed to relatively low levels, or I guess there is no safe level of lead exposure, that's really striking. That's a lot of people dying from something that cardiology and medical community is not really aware of. And there's a figure 3 [BELOW] that we will also show in the transcript, where you show the level where you start to see a takeoff. It starts very low and by 50 μg/liter, you're seeing a twofold risk and there's no threshold, it keeps going up. How many of us do you think are exposed to that type of level as adults, Bruce?Bruce Lanphear (02:39):Well, as adults, if we go back in time, all of us. If you go back to the 1970s when lead was still in gasoline, the median blood lead level of Americans was about 13 to 15 µg/dL. So we've all been exposed historically to those levels, and part of the reason we've begun to see a striking decline in coronary heart disease, which peaked in 1968. And by 1978, there was a 20% decline, 190,000 more people were alive than expected. So even in that first decade, there was this striking decline in coronary heart disease. And so, in addition to the prospective studies that have found this link between an increase in lead exposure and death from cardiovascular disease and more specifically coronary heart disease. We can look back in time and see how the decline in leaded gasoline led to a decline in heart disease and hypertension.Eric Topol (03:41):Yeah, but it looks like it's still a problem. And you have a phenomenal graph that's encouraging, where you see this 95% reduction in the lead exposure from the 1970s. And as you said, the factors that can be ascribed to like getting rid of lead from gasoline and others. But what is troubling is that we still have a lot of people that this could be a problem. Now, one of the things that was fascinating is that you get into that herbal supplements could be a risk factor. That we don't do screening, of course, should we do screening? And there's certain people that particularly that you consider at high risk that should get screened. So I wasn't aware, I mean the one type of supplements that you zoomed in on, how do you say it? Ayurvedic?Supplements With LeadBruce Lanphear (04:39):Oh yeah. So this is Ayurvedic medicine and in fact, I just was on a Zoom call three weeks ago with a husband and wife who live in India. The young woman had taken Ayurvedic medicine and because of that, her blood lead levels increased to 70 µg/dL, and several months later she was pregnant, and she was trying to figure out what to do with this. Ayurvedic medicine is not well regulated. And so, that's one of the most important sources when we think about India, for example. And I think you pointed out a really important thing is number one, we don't know that there's any safe level even though blood lead levels in the United States and Europe, for example, have come down by over 95%. The levels that we're exposed to and especially the levels in our bones are 10 to 100 times higher than our pre-industrial ancestors.Bruce Lanphear (05:36):So we haven't yet reached those levels that our ancestors were exposed to. Are there effects at even lower and lower levels? Everything would suggest, we should assume that there is, but we don't know down below, let's say one microgram per deciliter or that's the equivalent of 10 parts per billion of lead and blood. What we also know though is when leaded gasoline was restricted in the United States and Canada and elsewhere, the companies turned to the industrializing countries and started to market it there. And so, we saw first the epidemic of coronary heart disease in the United States, Canada, Europe. Then that's come down over the past 50 years. At the same time, it was rising in low to middle income countries. So today over 95% of the burden of disease from lead including heart disease is found in industrializing countries.Eric Topol (06:34):Right. Now, it's pretty striking, of course. Is it true that airlines fuel is still with lead today?Bruce Lanphear (06:45):Well, not commercial airlines. It's going to be a small single piston aircraft. So for example, when we did a study down around the Santa Clara County Airport, Reid-Hillview, and we can see that the children who live within a half mile of the airport had blood lead levels about 10% higher than children that live further away. And the children who live downwind, 25% higher still. Now, nobody's mapped out the health effects, but one of the things that's particularly troubling about emissions from small aircraft is that the particle size of lead is extraordinarily small, and we know how nanoparticles because they have larger surface area can be more problematic. They also can probably go straight up into the brain or across the pulmonary tissues, and so those small particles we should be particularly worried about. But it's been such a long journey to try to figure out how to get that out of aircraft. It's a problem. The EPA recognized it. They said it's an endangerment, but the industry is still pushing back.Eric Topol (07:55):Yeah, I mean, it's interesting that we still have these problems, and I am going to in a minute ask you what we can do to just eradicate lead as much as possible, but we're not there yet. But one study that seemed to be hard to believe that you cited in the review. A year after a ban leaded fuel in NASCAR races, mortality from coronary heart disease declined significantly in communities near racetracks. Can you talk about that one because it's a little bit like the one you just mentioned with the airports?Bruce Lanphear (08:30):Yeah. Now that study particularly, this was by Alex Hollingsworth, was particularly looking at people over 65. And we're working on a follow-up study that will look at people below 65, but it was quite striking. When NASCAR took lead out of their fuel, he compared the rates of coronary heart disease of people that live nearby compared to a control group populations that live further away. And he did see a pretty striking reduction. One of the things we also want to look at in our follow-up is how quickly does that risk begin to taper off? That's going to be really important in terms of trying to develop a strategy around preventing lead poisoning. How quickly do we expect to see it fall? I think it's probably going to be within 12 to 24 months that we'll see benefits.Eric Topol (09:20):That's interesting because as you show in a really nice graphic in adults, which are the people who would be listening to this podcast. Of course, they ought to be concerned too about children and all and reproductive health. But the point about the skeleton, 95% of the lead is there and the main organs, which we haven't mentioned the kidney and the kidney injury that occurs no less the cardiovascular, the blood pressure elevation. So these are really, and you mentioned not necessarily highlighted in that graphic, but potential cognitive hit as well. You also wrote about how people who have symptoms of abdominal pain, memory impairment, and high blood pressure that's unexplained, maybe they should get a blood level screening. I assume those are easy to get, right?Bruce Lanphear (10:17):Oh yeah, absolutely. You can get those in any hospital, any clinic across the country. We're still struggling with having those available where it's most needed in the industrializing countries, but certainly available here. Now, we don't expect that for most people who have those symptoms, lead poisoning is going to be the cause, right. It'd still be unusual unless you work in an industry, for example, smelting batteries to recycle them. We don't expect it to be real common, and we're not even sure, Eric, whether we should be doing widespread screening. If I looked at this as a population scientist, the real focus should be on identifying the sources. We mostly know where those are here and radically moving it down. Getting rid of the lead service lines, which was such a big part of what President Biden was doing, and it was perfect. For every dollar invested to reduce lead exposure from those lead service lines. Ronnie Levin at Harvard said there'd be a 35-fold return in cost, benefits really, and this has always been true, that reducing lead exposure throughout the past 40 years has always been shown to be amazingly cost beneficial. The problem is operating within a free market health system, even though there's tremendous social benefits, that benefit isn't going to be monetized or privatized. And so, who's going to make those decisions? We hope our government is, but that doesn't always play out.Eric Topol (11:52):Well. What's interesting is, as opposed to the problems we have today that are prominent such as the microplastic, nanoplastics, the air pollution, the forever chemicals, that just keep getting worse, I mean, they are just cumulative. This one, there was tremendous improvement, but it's still not enough. And I guess you're zooming in on the lead lines. That'd be the most important thing to work on today. Another thing that has come up, there's been trials, as you may I'm sure, because all over this field of chelation, there's a trial that was run by the NIH, supported by NH that looked at chelation to prevent coronary disease. Is there any evidence that people who have a problem with lead would benefit from chelation therapy?Bruce Lanphear (12:44):Well, there's two major studies that have been done, and Tony Lamas was in charge of both of them. The first one Trial to Assess Chelation Therapy (TACT) study, it was a randomized controlled trial, not intended specifically to focus on lead, but rather it was to look at sort of this alternative therapy. They found significant benefits about an 18% reduction in subsequent cardiac events. That led to a second study that was just published last year, and it was focused on people who had diabetes. They saw some benefit, but it wasn't significant. So whether that's because there wasn't enough variability and exposure, it's not entirely clear, but we've seen this with lead in IQ deficits in kids where we can show that we can reduce blood lead levels. But ultimately what tends to happen is once you've taken lead out of the blood, some of it's released again from the bone, but you still have all that lead in the bone that's there. You get some of it out, but you're not going to get the bulk of it out.The Lead-Estrogen HypothesisEric Topol (13:47):Right. It's a reservoir that's hard to reckon with. Yeah. Now another thing, you have a Substack that is called Plagues, Pollution & Poverty, and you wrote a really provocative piece in that earlier and April called How Estrogen Keeps Lead - and Heart Attacks - in Check, and basically you got into the lead estrogen hypothesis.Eric Topol (14:10):Can you enlighten us about that?Bruce Lanphear (14:12):Yeah. A lot of the seminal work in this area was done by Ellen Silbergeld, who's a brilliant and somewhat peculiar toxicologist and Ellen for years, I focused on childhood lead exposure, and for years Ellen would tell me, almost demolish me for not studying adults. And because she had found back in 1988 that as women go into menopause, their blood lead levels spike increased by about 30%, and that's where most of our lead is stored is in our bone. And so, as I was thinking about this, it all became clear because blood lead levels in boys and girls is about the same. It's comparable up until menarche, and then girls young women's blood leads fall by about 20%. And they stay 20% lower throughout the reproductive years until menopause. And especially during those first few years around menopause, perimenopause, you see fairly striking increases in the weakening of the bone and blood lead levels.Bruce Lanphear (15:19):So that might very well help to explain why estrogen is protected, because what happens is throughout the reproductive life, women are losing a little bit of lead every month. And estrogen is at its lowest during that time, and that's going to be when blood lead is at its highest because estrogen pushes lead into the bone. Not only that, women lose lead into the developing fetus when they're pregnant. So what Ellen found is that there was less of a spike around menopause for the women that had three or four pregnancies because they had offloaded that into their babies. So all of this, if you put it together, and this is of course in a very short note of it, you can see that lead increases dyslipidemia, it leads to tears in the endothelium of the arterial wall, it's going to increase thrombosis. All of these things that we think of as the classic atherosclerosis. Well, what estrogen does is the opposite of those. It decreases dyslipidemia, it repairs the arterial endothelial wall. So how much of it is that estrogen is protective, and how much is it that it's moving lead out of the system, making it less biologically available?Eric Topol (16:46):Yeah, I know. It's really interesting. Quite provocative. Should be followed up on, for sure. Just getting to you, you're a physician and epidemiologist, MD MPH, and you have spent your career on this sort of thing, right? I mean, is your middle name lead or what do you work on all the time?Bruce Lanphear (17:09):Yeah, I've been doing this for about 30 years, and one of my mentors, Herb Needleman spent 40 years of his career on it. And in some ways, Eric, it seems to me particularly in these very difficult entrenched problems like lead, we don't have any pharmaceutical company reaching out to us to promote what we do. We've got industry trying to squash what we do.Bruce Lanphear (17:35):It really does take a career to really make a dent in this stuff. And in a way, you can look at my trajectory and it is really following up on what Herb Needleman did and what Clare Patterson did, and that was finding the effects at lower and lower levels. Because what we do with lead and most other toxic chemicals, the ones that don't cause cancer, is we assume that there's a safe level or threshold until we prove otherwise. And yet when you look at the evidence, whether it's about asbestos and mesothelioma, air pollution and cardiovascular mortality, lead and cardiovascular mortality, benzene and leukemia, none of those exhibit a threshold. In some cases, the risks are steepest proportionately at the lowest measurable levels, and that really raises some tremendous challenges, right? Because how are we going to bring air pollution or lead down to zero? But at the same time, it also provides these tremendous opportunities because we know that they're causing disease. We know what the sources are. If we could only bring about the political will to address them, we could prevent a lot of death, disease, and disability. I mean, about 20% of deaths around the world every year are from air pollution, lead, and other toxic chemicals, and yet the amount of money we invest in them is just paltry compared to what we invest in other things. Which is not to pit one against the other, but it's to say we haven't invested enough in these.Eric Topol (19:14):No, absolutely. I think your point, just to make sure that it's clear, is that even at low levels, this is of course where most of the population exposure would be, and that's why that's so incriminating. Now, one of the things I just want to end up with is that we know that these are tiny, tiny particles of lead, and then the question is how they can synergize and find particulate matter of air pollution in the nanoplastic, microplastic story and binding to forever chemicals, PFAS. How do you process all that? Because it's not just a single hit here, it's also the fact that there's ability to have binding to the other environmental toxins that are not going away.Bruce Lanphear (20:10):That's right. And in a way, when we talk about lead playing this tremendous role in the rise and decline of coronary heart disease, we can't entirely separate it out, for example, from air pollution or cigarette smoke for that matter, nor plastic. So for example, with air pollution, if we look at air pollution over the past century, up until the 1980s, even into the 1990s, it was leaded, right? So you couldn't separate them. If you look at cigarette smoke, cigarette tobacco in the 1940s and 1950s was grown in fields where they used lead arsenic as an insecticide. So smokers even today have blood lead levels that are 20% higher than non-smokers, and people who are not smokers but exposed to secondhand smoke have blood lead levels 20% higher than non-smokers who aren't exposed to secondhand smoke. So in a way, we should try to tease apart these differences, but it's going to be really challenging. In a way we can almost think about them as a spectrum of exposures. Now with plastics, you can really think of plastics as a form of pollution because it's not just one thing. There's all these additives, whether it's the PFAS chemicals or lead, which is used as a stabilizer. And so, all of them really are kind of integrated into each other, which again, maybe there's some opportunity there if we really were ready to tackle.Eric Topol (21:40):And interestingly, just yesterday, it was announced by the current administration that they're stopping all the prior efforts on the forever chemicals that were initiated in the water supply. And I mean, if there's one takeaway from our discussion, it's that we have to get all over this and we're not paying enough attention to our environmental exposures. You've really highlighted spotlighted the lead story. And obviously there are others that are, instead of getting somewhat better, they're actually going in the opposite direction. And they're all tied together that's what is so striking here, and they all do many bad things to our bodies. So I don't know how, I'm obviously really interested in promoting healthy aging, and unless we get on this, we're chasing our tails, right?Bruce Lanphear (22:31):Well, I think that's right, Eric. And I was reading the tips that you'd written about in preparation for your book release, and you focused understandably on what each of us can do, how we can modify our own lifestyles. We almost need six tips about what our government should do in order to make it harder for us to become sick, or to encourage those healthy behaviors that you talked about. That's a big part of it as well. One of the things we're celebrating the hundredth anniversary. This is not really something to celebrate, but we are. The hundredth anniversary of the addition of tetraethyl lead to gasoline. And one of the key things about that addition, there was this debate because when it was being manufactured, 80% of the workers at a plant in New Jersey suffered from severe lead poisoning, and five died, and it was enough that New York City, Philadelphia and New Jersey banned tetraethyl lead.Bruce Lanphear (23:31):Then there was this convening by the US Surgeon General to determine whether it was safe to add tetraethyl lead to gasoline. One scientist, Yandell Henderson said, absolutely not. You're going to create a scourge worse than tuberculosis with slow lead poisoning and hardening of your arteries. Robert Kehoe, who represented the industry said, we know lead is toxic, but until you've shown that it's toxic when added to gasoline, you have no right to prohibit us from using it. So that is now known as the Kehoe rule, and it's relevant not only for lead, but for PFAS, for air pollution, for all these other things, because what it set as a precedent, until you've shown that these chemicals or pollution is toxic when used in commerce, you have no right to prohibit industry from using it. And that's the fix we're in.Eric Topol (24:27):Well, it sounds too much like the tobacco story and so many other things that were missed opportunities to promote public health. Now, is Canada doing any better than us on this stuff?Bruce Lanphear (24:40):In some ways, but not in others. And one of the interesting thing is we don't have standards, we have guidelines. And amazingly, the cities generally try to conform to those guidance levels. With water lead, we're down to five parts per billion. The US is sticking around with ten parts per billion, but it's not even really very, it's not enforced very well. So we are doing better in some ways, not so good in other ways. The European Union, generally speaking, is doing much better than North America.Eric Topol (25:15):Yeah, well, it doesn't look very encouraging at the moment, but hopefully someday we'll get there. Bruce, this has been a really fascinating discussion. I think we all should be thankful to you for dedicating your career to a topic that a lot of us are not up on, and you hopefully are getting us all into a state of awareness. And congratulations on that review, which was masterful and keep up the great work. Thank you.Bruce Lanphear (25:42):Thank you, Eric. I appreciate it.________________________________________________My Recommendations for Preventing Heart Disease (Markedly Truncated from Text and Graphics Provided in SUPER AGERS)Recently the Washington Post asked me for a listicle of 10 ways to prevent heart disease. I generally avoid making such lists but many people have de-subscribed to this newspaper, never subscribed, or missed the post, so here it is with links to citations:Guest column by Eric Topol, MDThe buildup of cholesterol and other substances in the wall of our arteries, known as atherosclerosis, is common. It can lead to severe plaques that narrow the artery and limit blood flow, or to a crack in the artery wall that can trigger blood clot formation, resulting in a heart attack.While we've seen some major advances in treating heart disease, it remains the leading killer in the United States, even though about 80 percent of cases are considered preventable. There are evidence-based steps you can take to stave it off. As a cardiologist, here's what I recommend to my patients.1. Do both aerobic and resistance exerciseThis is considered the single most effective medical intervention to protect against atherosclerosis and promote healthy aging. Physical activity lowers inflammation in the body. Evidence has shown that both aerobic and strength training forms of exercise are important. But only 1 in 4 Americans meet the two activity guidelines from the American Heart Association: aerobic exercise of 150 minutes per week of at least moderate physical activity, such as walking, bicycling on level ground, dancing or gardening, and strength training for at least two sessions per week, which typically translates to 60 minutes weekly.The protective benefit of exercise is seen with even relatively low levels of activity, such as around 2,500 steps per day (via sustained physical activity, not starting and stopping), and generally increases proportionately with more activity. It used to be thought that people who exercise only on the weekend — known as “weekend warriors” — put themselves in danger, but recent data shows the benefits of exercise can be derived from weekend-only workouts, too.2. Follow an anti-inflammatory dietA predominantly plant-based diet — high in fiber and rich in vegetables, fruits and whole grains, as seen with the Mediterranean diet — has considerable evidence from large-scale observational and randomized trials for reducing body-wide inflammation and improving cardiovascular outcomes.Foods rich in omega-3 fatty acids, such as salmon, also form part of a diet that suppresses inflammation. On the other hand, red meat and ultra-processed foods are pro-inflammatory, and you should limit your consumption. High protein intake of more than 1.4 grams per kilogram of body weight per day — around 95 grams for someone who is 150 pounds — has also been linked to promoting inflammation and to atherosclerosis in experimental models. That is particularly related to animal-based proteins and the role of leucine, an essential amino acid that is obtained only by diet.3. Maintain a healthy weightBeing overweight or obese indicates an excess of white adipose tissue. This kind of tissue can increase the risk of heart disease because it stores fat cells, known as adipocytes, which release substances that contribute to inflammation.In studies, we've seen that glucagon-like peptide (GLP-1) drugs can reduce inflammation with weight loss, and a significant reduction of heart attacks and strokes among high-risk patients treated for obesity. Lean body weight also helps protect against atrial fibrillation, the most common heart rhythm abnormality.4. Know and avoid metabolic syndrome and prediabetesTied into obesity, in part, is the problem of insulin resistance and metabolic syndrome. Two out of three people with obesity have this syndrome, which is defined as having three out of five features: high fasting blood glucose, high fasting triglycerides, high blood pressure, low high-density lipoprotein (HDL) and central adiposity (waist circumference of more than 40 inches in men, 35 inches in women).Metabolic syndrome is also present in a high proportion of people without obesity, about 50 million Americans. Prediabetes often overlaps with it. Prediabetes is defined as a hemoglobin A1c (a measure of how much glucose is stuck to your red blood cells) between 5.7 and 6.4 percent, or a fasting glucose between 100 and 125 milligrams per deciliter.Both metabolic syndrome and prediabetes carry an increased risk of heart disease and can be prevented — and countered — by weight loss, exercise and an optimal diet.As the glucagon-like peptide drug family moves to pills and less expense in the future, these medications may prove helpful for reducing risk in people with metabolic syndrome and prediabetes. For those with Type 2 diabetes, the goal is optimizing glucose management and maximal attention to lifestyle factors.5. Keep your blood pressure in a healthy rangeHypertension is an important risk factor for heart disease and is exceptionally common as we age. The optimal blood pressure is 120/80 mm Hg or lower. But with aging, there is often an elevation of systolic blood pressure to about 130 mm Hg, related to stiffening of arteries. While common, it is still considered elevated.Ideally, everyone should monitor their blood pressure with a home device to make sure they haven't developed hypertension. A mild abnormality of blood pressure will typically improve with lifestyle changes, but more substantial elevations will probably require medications.6. Find out your genetic riskWe now have the means of determining your genetic risk of coronary artery disease with what is known as a polygenic risk score, derived from a gene chip. The term polygenic refers to hundreds of DNA variants in the genome that are linked to risk of heart disease. This is very different from a family history, because we're a product of both our mother's and father's genomes, and the way the DNA variants come together in each of us can vary considerably for combinations of variants.That means you could have high or low risk for heart disease that is different from your familial pattern. People with a high polygenic risk score benefit the most from medications to lower cholesterol, such as statins. A polygenic risk score can be obtained from a number of commercial companies, though it isn't typically covered by insurance.I don't recommend getting a calcium score of your coronary arteries via a computed tomography (CT) scan. This test is overused and often induces overwhelming anxiety in patients with a high calcium score but without symptoms or bona fide risk. If you have symptoms suggestive of coronary artery disease, such as chest discomfort with exercise, then a CT angiogram may be helpful to map the coronary arteries. It is much more informative than a calcium score.7. Check your blood lipidsThe main lipid abnormality that requires attention is low-density cholesterol (LDL), which is often high and for people with increased risk of heart disease should certainly be addressed. While lifestyle improvements can help, significant elevation typically requires medications such as a statin; ezetimibe; bempedoic acid; or injectables such as evolocumab (Repatha), alirocumab (Praluent) or inclisiran (Leqvio). The higher the risk, the more aggressive LDL lowering may be considered.It should be noted that the use of potent statins, such as rosuvastatin or atorvastatin, especially at high doses, is linked to inducing glucose intolerance and risk of Type 2 diabetes. While this is not a common side effect, it requires attention since it is often missed from lack of awareness.A low high-density lipoprotein (HDL) cholesterol often responds to weight loss and exercise. We used to think that high HDL was indicative of “good cholesterol,” but more recent evidence suggests that is not the case and it may reflect increased risk when very high.To get a comprehensive assessment of risk via your blood lipids, it's important to get the apolipoprotein B (apoB) test at least once because about 20 percent of people have normal LDL and a high apoB.Like low HDL, high fasting triglycerides may indicate insulin resistance as part of the metabolic syndrome and will often respond to lifestyle factors.The lipoprotein known as Lp(a) should also be assessed at least once because it indicates risk when elevated. The good news is scientists are on the cusp of finally having medications to lower it, with five different drugs in late-stage clinical trials.8. Reduce exposure to environmental pollutantsIn recent years, we've learned a lot about the substantial pro-inflammatory effects of air pollution, microplastics and forever chemicals, all of which have been linked to a higher risk of heart disease. In one study, microplastics or nanoplastics in the artery wall were found in about 60 percent of more than 300 people. Researchers found a vicious inflammatory response around the plastics, and a four- to fivefold risk of heart attacks or strokes during three years of follow-up.While we need policy changes to address these toxic substances in the environment, risk can be reduced by paying attention to air and water quality using filtration or purification devices, less use of plastic water bottles and plastic storage, and, in general, being much more aware and wary of our pervasive use of plastics.9. Don't smoke This point, it should be well known that cigarette smoking is a potent risk factor for coronary artery disease and should be completely avoided.10. Get Good SleepAlthough we tend to connect sleep health with brain and cognitive function, there's evidence that sleep regularity and quality are associated with less risk of heart disease. Regularity means adhering to a routine schedule as much as possible, and its benefit may be due to our body's preference for maintaining its circadian rhythm. Sleep quality — meaning with fewer interruptions — and maximal deep sleep can be tracked with smartwatches, fitness bands, rings or mattress sensors.Sleep apnea, when breathing stops and starts during sleep, is fairly common and often unsuspected. So if you're having trouble sleeping or you snore loudly, talk to your doctor about ruling out the condition. Testing for sleep apnea can involve checking for good oxygen saturation throughout one's sleep. That can be done through a sleep study or at home using rings or smartwatches that include oxygen saturation in their sensors and body movement algorithms that pick up disturbed breathing.Eric Topol, MD, is a cardiologist, professor and executive vice president of Scripps Research in San Diego. He is the author of “Super Agers: An Evidence-Based Approach to Longevity” and the author of Ground Truths on Substack.*********************°°°°°°°°°°°°°°°°°°°°Thanks to many of you Ground Truths subscribers who helped put SUPER AGERS on the NYT bestseller list for 4 weeks.Here are 2 recent, informative, and fun conversations I had on the topicMichael Shermer, The SkepticRuss Roberts, EconTalk I'm also very appreciative for your reading and subscribing to Ground Truths.If you found this interesting PLEASE share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past three years. Just a week ago we just had nearly 50 interns (high school, college and medical students) present posters of the work they did over the summer and it was exhilarating! Some photos below Get full access to Ground Truths at erictopol.substack.com/subscribe
Josh Wageman is a board-certified Clinical Lipid Specialist dedicated to transforming the way we understand and treat heart disease. With a deep expertise in cholesterol, metabolic health, and cardiovascular risk, he helps patients cut through the noise and take control of their health using evidence-based, personalized strategies. Known for translating complex science into actionable steps, Josh is passionate about prevention and proving that heart disease doesn't have to be inevitable. In this episode, Dr. Brian and Josh talk about… (00:00) Intro (00:32) Josh's interesting and varied career path (04:31) Understanding cardiovascular disease in a nutshell (8:15) Understanding lipoproteins (10:10) Why lipids are controversial and what we can all agree on (12:28) LDL and HDL particles (19:35) Endurance athletes and coronary calcium (29:54) Atherosclerosis, carnivore, and gut dysbiosis (39:46) Advanced lipid panels (40:29) Statins and LDL (44:13) Pros and cons of statins (49:54) Supplements that may be helpful for cardiovascular health (52:44) Rapping and singing about lipids and heart health (55:09) Science and faith; physical health and spiritual health (01:02:25) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Josh Wageman: IG: https://www.instagram.com/wagemanjosh/ Book: https://www.amazon.com/Security-System-Lipid-Neighborhood-Complicating/dp/B0DTJ1HJ4Y Dr. Brian Lenzkes: Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian: Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro Instagram: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together. Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more. Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888 Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/
Visit https://longevitybuilders.com/to discover the book and The Longevity Builder Health Lab.Key ConceptsThe Workshop Analogy: Knowledge requires tools. The Longevity Builder Health Lab is introduced as a digital "workshop" for health, inspired by his son's physical woodworking workshop.VO2 Max & Hazard Ratio: A low VO2 Max (your body's oxygen efficiency score) has a Hazard Ratio of 5.0—a 400% increased risk of premature death, making it the most powerful predictor of longevity.Hypoxic Training: This involves exercising in a low-oxygen environment that mimics high altitude, forcing your body to adapt and improve its oxygen efficiency.Shane uses analogies to simplify the benefits:Cardiovascular Overhaul: Your heart's main pumping chamber gets bigger, increasing its capacity (stroke volume). This lowers your resting heart rate. (Analogy: A standard car engine is swapped for a powerful V8.) Blood flow improves, stimulating Nitric Oxide production, which widens arteries and lowers blood pressure. (Analogy: A city planner widening roads.) HDL cholesterol increases, acting like a cleanup crew that removes plaque. (Analogy: An elite hazmat crew cleaning a toxic spill.)Metabolic Upgrade: Exercise creates an insulin-independent pathway for cells to absorb glucose, combating insulin resistance. (Analogy: A high-security building with a secret VIP back door for fuel deliveries.)Cellular Enhancements: Hypoxic training builds new, more efficient mitochondria (cellular power plants) and recycles old ones. (Analogy: A city upgrading its power grid.) It also increases red blood cells, enhancing oxygen transport. (Analogy: A logistics company upgrading its fleet of vans to semi-trucks.)Brain Health: The process releases BDNF ("Miracle-Gro for the brain"), which supports neuron growth and connections. It also improves deep, restorative sleep, during which the brain flushes out toxins. (Analogy: A library's A-Team and an elite overnight restoration crew.)Shane ends with a powerful personal story about his father, who died at 46 from a preventable heart attack, and emphasizes the importance of a personal "why" for building longevity. He encourages listeners to find an altitude exercise class and visit longevitybuilders.com for a free tracking tool.The Science Behind the UpgradeThe Final Message
This episode is brought to you by the Primal Tallow Balms.Dr Kendrick emphasizes the lack of scientific evidence linking high cholesterol to heart disease and argues that a higher fat diet can have positive effects on health. The discussion also covers the complexities of LDL cholesterol, the importance of understanding various health markers, and the potential effects of adopting a high-fat diet. In this conversation, Dr. Malcolm Kendrick discusses the complexities of heart health, focusing on the role of blood clots, the impact of diet on cardiovascular health, and the misconceptions surrounding cholesterol and statins. He emphasizes the importance of understanding the glycocalyx and its protective role in blood vessels, the benefits of a high-fat diet, and the potential for plaque regression. Kendrick also critiques the use of statins, arguing that their benefits are often overstated and come with significant side effects. Takeaways* Cholesterol is often misunderstood in relation to heart disease.* Changing medical opinions is challenging due to entrenched beliefs.* High-fat diets can have positive health impacts.* LDL cholesterol is often mischaracterized as harmful.* The relationship between dietary fat and heart health is complex.* Markers like triglycerides and HDL are important for assessing heart health.* Insulin resistance is a key factor in heart disease risk.* The disease process in arteries can take decades to develop.* LDL levels can be influenced by carbohydrate intake, not just fat.* Understanding the nuances of cholesterol can empower patients. Blood clots form on artery walls and can lead to heart disease.* A high-fat diet can improve blood sugar levels and overall health.* The glycocalyx is crucial for protecting blood vessels from damage.* Diabetes damages the glycocalyx, increasing heart disease risk.* A 30-day high-fat diet can lead to significant health improvements.* Stopping the progression of plaque is more important than regression.* Statins may increase nitric oxide but have many adverse effects.* The average increase in life expectancy from statins is minimal.* Challenging your doctor about statin use can be beneficial.* Understanding the true causes of heart disease is essential for prevention.
In this solo episode, I delve deep into a topic that could revolutionise your understanding of cardiovascular health. The focus shifts from the conventional marker, LDL cholesterol, to a more predictive measure that has been right under our noses. Prepare to have your mind blown as I unpack decades of research, dismantles myths, and unveil practical steps for a healthier life. What You'll Learn: The Real Marker of Risk: Discover a much stronger predictor of cardiovascular and metabolic disease risk than LDL cholesterol. Challenging Norms: Understand why relying solely on LDL cholesterol is like flipping a coin when assessing heart disease risk. A Game-Changer: Learn about the Framingham study's revelation that this measure is 3 to 5 times more predictive of heart attack risk. Impacts Beyond Heart Health: Find out how this ratio also predicts risk for metabolic diseases like type 2 diabetes. Practical Steps: Explore dietary and lifestyle changes that can improve your key ratio, enhancing overall metabolic health. Key Takeaways: The triglyceride to HDL ratio offers a more accurate risk assessment than focusing solely on LDL cholesterol. Maximising heart and metabolic health involves more than just medication; lifestyle changes play a crucial role. Understanding your body's response to carbohydrates is key to optimising your lipid profile. The medical community's focus on LDL cholesterol is outdated—empower yourself with current research to guide your health decisions. Simple changes such as low-carb diets, exercise, and intermittent fasting can significantly impact your health outcomes. Support the Podcast: If you enjoyed this episode, consider subscribing and leaving a review on your preferred podcast platform. Your support helps us bring valuable conversations like this one to a wider audience. If this perspective on heart health was enlightening, consider sharing it with friends and family. Encourage them to rethink traditional markers of health and embrace more comprehensive measures. Stay connected with the evolving world of cardiovascular research and empower yourself with knowledge for a healthier, longer life. Final Thoughts: Embrace the shift towards a more nuanced understanding of heart health. As we grow more informed, the tools to live healthier, longer lives are within our grasp—let's use them to navigate our health journey intelligently. 00:00 Introduction and Podcast Name Change 01:31 Today's Topic: Cardiovascular Disease and LDL Cholesterol 03:54 The Limitations of LDL Cholesterol 07:52 The Game Changer Ratio 09:01 Research and Studies on this alternative Ratio 17:20 Practical Applications and Lifestyle Changes 29:32 Medications and Advanced Research 41:25 Conclusion and Key TakeawaysSee omnystudio.com/listener for privacy information.
In this episode, Brent sits down with Dr. Richard Maurer, a naturopathic doctor and author of The Blood Code, a book about metabolic health. They discuss markers like A1C, LDL, HDL, triglycerides, and how these impact risks for conditions such as diabetes and heart disease. Dr. Maurer shares his personal journey of reversing prediabetes and provides actionable insights on diet, exercise, and maintaining a balance between endurance and weight training to optimize health. The conversation then shifts to Dr. Maurer's approach to his Parkinson's diagnosis. With a focus on information, community, and proactive measures, he details how he has adapted his lifestyle to slow the progression of this neurodegenerative disease. Hope you enjoy.
Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]
Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]
Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]
Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]
As a PhD nutritionist and registered dietitian, I'm breaking down 7 powerful foods that naturally lower bad cholesterol—no statins required. Learn how these foods reduce inflammation, improve HDL, and support heart health, all backed by science and real client results.GET A CUSTOMIZED WEIGHT LOSS PLAN: Have a free 1-on-1 call with our Expert Nutritionists
Welcome to Protecting Your Nest with Dr. Tony Hampton. Raymond Nazon is a carnivore coach and the inventor of the priming concept for the carnivore diet. The list of issues he was experiencing prior to carnivore includes: pre-diabetes, plantar fasciitis, waist size of 44, rosacea, mid-back pain, arthritic knee and finger joints, heel spurs, poor libido, high triglycerides, low HDL, blood pressure, pre-hypertension, snoring, dandruff, acne, diminishing eyesight, poor wound-healing, irritable bowel disease, chronic constipation, constant brain fog, insomnia and more. Now, after following a carnivore diet since 2017, Raymond has been set free to do and be so much more than he ever thought possible. In this discussion, Dr. Tony and Raymond talk about: (00:00) Intro (04:30) Raymond's carnivore journey—why he started and what he has learned along the way (12:21) How Raymond has been able to stay consistent with his diet over the years (15:19) The concept of ‘priming' for the carnivore diet (19:39) The emotional challenges people face when switching to carnivore (24:46) Spices and seasonings on the carnivore diet (28:28) Non-scale victories Raymond has had following a carnivore diet (31:33) Orange Theory, Karate, Jiu Jitsu, hiking, and running (35:41) Why Raymond shares his message with others (38:57) A truly ASTOUNDING carnivore success story (42:29) Fasting and the carnivore diet (47:40) How Raymond's family has benefited from the carnivore diet (50:15) Increased libido on carnivore (52:38) The MYTH about carnivore and heart disease (55:34) Outro Thank you for listening to Protecting Your Nest. For additional resources and information, please see the links below. Links: Resources Mentioned in this Episode: The Steak and Butter Gang: https://sbg-s-meat-up.mn.co Dr. Tony's video on Carnivore Priming: https://www.youtube.com/watch?v=6IL6KsHgtTU Raymond Nazon: YouTube: https://www.youtube.com/channel/UC8l7xBJzug3R6lDYz1dhigw FB: https://www.facebook.com/rnazon/ IG: https://www.instagram.com/raymondnazon/?hl=en Email: rnazon@gmail.com 90 Day Challenge: https://sbg-s-meat-up.mn.co/plans/316276?bundle_token Dr. Tony Hampton: Linktree: https://linktr.ee/drtonyhampton Instagram Account: https://www.instagram.com/drtonyhampton/ LinkedIn Account: https://www.linkedin.com/in/drtonyhampton/ Ritmos Negros Podcast: https://podcasts.apple.com/us/podcast/ritmos-negros/id1534043495 Q Med: https://qmedcme.com Symposium for Metabolic Health Lectures: https://www.lowcarbusa.org/smhp-symposiums/san-diego-2022/ How Waking Up Every Day at 4:30 Can Change Your Life: https://www.youtube.com/watch?v=qOEB1Fr0_MM • • Keto Mojo: https://keto-mojo.com/speakers/tony-hampton/
On this episode of Crazy Wisdom, Stewart Alsop talks with Larry Diamond, co-founder of Healing with the Diamonds, about his journey from severe metabolic illness to vibrant health and his work helping others do the same. They explore topics like heart-brain coherence, the alchemical journey, insulin resistance, seed oils, and the deeper spiritual dimensions of healing, weaving in references to David Hawkins, Rupert Sheldrake, and the lost wisdom of the divine feminine. Larry shares insights on metabolic testing, ancestral eating, and the importance of authentic living, while also touching on the role of parasites—his term for the forces keeping humanity in fear and incoherence. You can find more about Larry and his work, as well as access his consulting, at healingwiththediamonds.com, on Instagram and Facebook at Healing with the Diamonds, or listen in iTunes to his upcoming podcast.Check out this GPT we trained on the conversationTimestamps00:00 Stewart Alsop introduces Larry Diamond of Healing with the Diamonds; they discuss his healing journey, health coaching, and the meaning of heart-brain coherence.05:00 Alchemical journey, crystals, the hero's journey, integrating masculine and feminine energies, and the idea of parasites feeding on fear.10:00 Kindness vs niceness, morphic fields, Rupert Sheldrake's theories, and quantum entanglement as evidence of interconnectedness.15:00 Scientism vs true science, metabolic illness, citizen science, Larry's 2013 health transformation.20:00 Metabolic syndrome, C-reactive protein, fasting insulin, insulin resistance, and Larry's weight loss story.25:00 Seed oils, refined carbs, ultra-processed foods, and strategies for restoring metabolic health.30:00 Carb cycling, primal eating, intuitive healing, and ancestral wisdom.35:00 Spirituality beyond religion, Yeshua vs Jesus, divine feminine, and writing your own gospel.40:00 Living authentically, kindness in daily life, and finding healing in sovereignty and connection.Key InsightsLarry Diamond shares how his journey from severe metabolic illness to vibrant health became the foundation for Healing with the Diamonds. He explains how hitting rock bottom in 2013 inspired him to reject mainstream dietary advice and embrace a primal, whole foods approach that reversed his insulin resistance and helped him lose over 100 pounds.A major theme of the conversation is heart-brain coherence, which Larry describes as essential for true wisdom and discernment. He connects this to ancient teachings, referencing Yeshua's “sword of discernment” and suggesting that Western culture intentionally suppressed this knowledge to keep people in fear and mental fragmentation.The episode explores the alchemical journey as a metaphor for inner transformation, likening it to Joseph Campbell's hero's journey. Larry emphasizes integrating masculine and feminine energies and overcoming ego as key steps in remembering our divine nature and embodying authenticity.Larry critiques scientism, which he calls the inversion of true science, and encourages listeners to reclaim citizen science as a path to health sovereignty. He shares practical tools like testing for C-reactive protein, A1C, fasting insulin, and using triglycerides-to-HDL ratios to assess metabolic health.He identifies the “Big Four” dietary culprits—seed oils, refined carbs, ultra-processed foods, and sugar—as drivers of chronic illness and advocates returning to ancestral foods rich in natural fats and nutrients. He stresses that flavor and enjoyment are critical for sustainable healing.On the spiritual side, Larry reframes the Abrahamic religions as distortions of deeper wisdom traditions, contrasting the figure of Yeshua (aligned with love and sovereignty) with the institutionalized Jesus narrative. He highlights the divine feminine, Sophia, as a source of intuition and co-creation with the cosmos.Finally, Larry encourages listeners to “write your own gospel and live your own myth,” seeing authentic, kind, and sovereign living as both a spiritual and practical act of resistance to what he calls the parasite class—forces of fear and manipulation seeking to block human awakening.
Found My Fitness - Rhonda Patrick Key Takeaways To some degree, insulin resistance is a common root cause for most chronic diseases A low-carb diet may offer a metabolic advantage by reducing insulin levels, which enhances metabolic flexibility and improves energy regulationFat tissue has a much higher metabolic rate when insulin levels are lowSince there is much more metabolic uncoupling, the body's engine revs up to burn energy just to create heat How to reverse a diabetes diagnosis in 90 days Control carbs – focus on whole fruits and vegetables, limiting sugary or starchy choices like bananas, pineapples, and mangoes Prioritize protein and do not fear fat – eat protein-rich foods regularly, and do not worry too much about naturally occurring fats Time meals and exercise – Eat more calories earlier in the day, avoid late-night eating, and take short walks after your biggest meals to reduce blood sugar spikesEating an evening snack spikes your blood sugar and ramps up the sympathetic nervous system, thus increasing body temperature and increasing the likelihood of insomnia and poor sleep; so do not eat within the 3-4 hours before bed Muscle is a great glucose consumer: The more muscle you have, the more metabolic wiggle room you have because muscle serves as a glucose sink Blood-sugar-lowering supplements that work:magnesium,alpha lipoic acid (ALA),berberine, andapple cider vinegar Eating too much linoleic acid (from seed oils) can lead to the production of a toxic substance (4H&E) that prevents your body from creating new small fat cells, and instead forces existing fat cells to just swell upConcerning GLP-1 dosing, caution is warranted; it is probably better to microdose these powerful drugs and think of them as short-term behavioral modification tools instead of lifelong prescriptions The top biomarkers to measure to determine metabolic health and aging:(1) fasting insulin; want below 6 µIU/mL), (2) Triglyceride-to-HDL ratio; want ratio under 1.5, and (3) Uric acid; want lower levels generallyLower your insulin by starting with tomorrow's breakfast: Either fast through breakfast and drink coffee, tea, or yerba mateOr if you do want to eat, then choose low-glycemic-load vegetables and berries, and consume more protein and fat Do whatever you can to keep your insulin in check for as long as possible throughout the day; the longer the insulin is low, the more you will improve your insulin sensitivity Read the full notes @ podcastnotes.org Get access to 130 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunction and highlights actionable, evidence-based tactics for improving metabolic health. Ben also addresses pressing questions about popular weight loss medications like Ozempic and other GLP-1 agonists: Are they groundbreaking solutions, or shortcuts with hidden metabolic consequences? Timestamps: (0:00) Introduction (4:51) Can you be insulin resistant with normal glucose levels? (8:30) Can glucose monitors detect hidden insulin resistance? (10:01) What your skin reveals about insulin resistance (11:25) Why is insulin resistance behind so many chronic diseases? (15:46) Does obesity cause insulin resistance—or vice versa? (22:38) Insulin's surprising roles beyond blood sugar control (23:36) What's driving weight gain—insulin or calories? (30:30) Do saturated fats cause insulin resistance? (37:02) Why refined carbs amplify risks from saturated fat (40:04) Fructose vs. refined sugar—which spikes insulin more? (41:01) High-carb vs. keto—which diet controls hunger better? (45:27) Why low-carb diets might provide a metabolic advantage (47:36) Does exercise give you metabolic ‘wiggle room'? (52:00) Why strength training beats cardio for insulin sensitivity (54:03) Should you lower insulin before cutting calories? (57:12) Does meal frequency drive insulin resistance? (1:00:32) Is nighttime snacking giving you insomnia? (1:02:24) Can a sugary breakfast lead to overeating later? (1:07:19) Does late-night eating disrupt sleep more than blue light? (1:08:59) Can one bad night's sleep trigger insulin resistance? (1:12:23) Can air pollution cause weight gain? (1:16:15) Vaping vs. smoking—which is worse for metabolic health? (1:17:40) Can statins and antidepressants trigger weight gain? (1:20:22) How to reverse insulin resistance in 90 days (1:26:59) Does apple cider vinegar really lower blood sugar? (1:30:54) Ketone supplements—are the metabolic benefits real? (1:36:34) Why some ethnicities get diabetes without obesity (1:44:28) How oversized fat cells trigger metabolic chaos (1:49:28) Do seed oils silently promote insulin resistance? (1:52:44) Seed oils—always harmful or only when heated? (1:58:35) Fat, muscle, or liver—where does insulin resistance start? (2:04:21) Do fat cells shrink or disappear with weight loss? (2:07:05) Are shrunken fat cells still insulin resistant? (2:08:15) Can exercise and cold therapy specifically shrink visceral fat? (2:09:40) Injecting insulin for muscle—are the risks worth it? (2:12:45) Are drugs like Ozempic a shortcut or solution for obesity? (2:19:12) Are current GLP-1 agonist doses too high? (2:20:02) Microdosing GLP-1 drugs—a solution for carb cravings? (2:26:01) Do these medications cause muscle loss—or is it poor nutrition? (2:28:30) Do GLP-1 agonist benefits extend beyond weight loss? (2:30:41) Could these treatments actually promote longevity? (2:36:12) The dark side of GLP-1 drugs—can they trigger depression? (2:39:31) Insulin vs. glucose—what really drives accelerated aging? (2:44:34) How high glucose levels damage cells—from glycolysis to sorbitol (2:46:40) How insulin shuts down your body's stress defenses (2:51:15) Which biomarkers best predict biological aging? (2:55:05) One simple breakfast change to lower insulin (2:57:19) Does eating dinner early improve insulin sensitivity? Show notes, transcript, and summary are available by clicking here Watch this episode on YouTube
Optimiza tu LDL Colesterol e interpreta tu analítica o las de tus pacientes hoy, sin fármacos, aplicando estrategias nutricionales y suplementos clave con dosis y ciencia. Accede aquí:https://philhugo.com/producto/ldl-colesterol/ ¡Te espero dentro!Los suplementos be levels mencionados que formulo personalmente: Tu código de descuento: INTERGALACTICOBerberina: https://shop.belevels.com/products/berberine?sca_ref=745165.uf0cpcacla Omega 3: https://belevels.com/products/omega3?sca_ref=745165.uf0cpcaclaTriple Magnesio: https://belevels.com/products/magnesium?variant=47417739379012.uf0cpcacla Dosis y los demás explicados en el curso de Control Absoluto del LDL Colesterol.¿Sigues una dieta cetogénica estricta y tu LDL se ha disparado a niveles que asustarían a cualquier médico? No estás solo. En este episodio, desentrañamos la fisiología del Lean Mass Hyperresponder (LMHR): un perfil metabólico donde el colesterol LDL se eleva no por enfermedad, sino por eficiencia energética. Aprende cómo tu hígado, en ausencia de glucosa, convierte grasa en combustible a través de VLDL y LDL. Descubre por qué un LDL de 300 mg/dL puede ser normal si tu HDL está alto, tus triglicéridos bajos y tu inflamación es cero. Estudio a estudio, desmonto los miedos injustificados y propone estrategias clínicas reales para modular tu LDL si es necesario, desde el aumento de carbohidratos limpios hasta la optimización tiroidea y muscular. Este episodio no es para quien se conforma con los rangos de laboratorio estándar. Es para quien quiere entender su cuerpo desde la lógica metabólica y tomar decisiones con ciencia, no con miedo.ReferenciasApoB es biomarcador y posible diana terapéutica cardiovascular. Behbodikhah, Jennifer et al. “Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.” Metabolites vol. 11,10 690. 8 Oct. 2021LDL sube mucho en "lean mass hyper-responders" con dieta baja en carbohidratos. Norwitz, Nicholas G et al. “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype.” Current developments in nutrition vol. 6,1 nzab144. 30 Nov. 2021Marcadores tiroideos y composición corporal predicen cambios en LDL con dieta cetogénica. Cooper, Isabella D et al. “Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.” Frontiers in endocrinology vol. 14 1326768. 21 Dec. 2023Omega-3 mejora dislipidemia en relación dosis-respuesta. Wang, Tianjiao et al. “Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.” Journal of the American Heart Association vol. 12,11 (2023): e029512.Omega-3 de prescripción tiene efectos lipídicos beneficiosos. Bays, Harold E et al. “Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications.” Expert review of cardiovascular therapy vol. 6,3 (2008): 391-409La berberina reduce lípidos, sola o combinada. Koppen, Laura M et al. “Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review.” Journal of evidence-based complementary & alternative medicine vol. 22,4 (2017): 956-968.Niacina baja lipoproteína(a) según fenotipo de apo(a). Artemeva, N V et al. “Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype.” Atherosclerosis. Supplements vol. 18 (2015): 53-8
Story at-a-glance Dragon fruit delivers antioxidant protection, gut support, and metabolic benefits, making it an easy way to upgrade your fruit intake Research shows that 100 grams of dragon fruit, about 1/2 cup, daily lowers LDL cholesterol by up to 69%, raises HDL by over 60%, and reduces triglycerides within weeks Bioactive compounds in the flesh, seeds, and even peel help fight inflammation, protect your liver, and feed beneficial gut bacteria like Akkermansia and Lactobacillus Dragon fruit's natural sugars provide steady energy without blood sugar crashes, making it an ideal pre-workout snack or midday pick-me-up It's especially helpful for pregnancy, digestive sluggishness, and skin repair, thanks to its folate content, natural hydration, and collagen-boosting vitamin C
Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the importance of understanding cholesterol in his podcast. He explains that cholesterol is crucial for cell membranes, hormone formation, and vitamin transport, and that LDL and HDL are transport vehicles for cholesterol. Dr. Bishop clarifies that cholesterol's impact on heart health is complex, as high LDL doesn't always indicate artery plaque, and low cholesterol doesn't always mean healthy arteries. He emphasizes the importance of coronary artery calcium scoring, particle numbers, and other factors in assessing artery health and predicting risk. For secondary prevention, lowering cholesterol is crucial, while primary prevention requires a personalized approach, considering individual risk factors and imaging.
In this episode of Proven Health Alternatives, I sit down with Dr. Darren Schmidt to explore one of the most promising tools in functional medicine today: the MVX Plus test. Launched in 2025, this next-gen blood panel goes far beyond standard labs—offering a deeper lens into chronic inflammation, mitochondrial dysfunction, nutrient deficiencies, and more. Dr. Schmidt breaks down the six core markers—from GlycA to citrate to branched-chain amino acids—and explains how they uncover hidden vulnerabilities affecting your healthspan. We also dive into practical insights, like the importance of vitamin B1, the dangers of ultra-processed diets, and how MVX can detect issues even when standard tests look “normal.” If you're serious about optimizing longevity, identifying root causes, or catching problems before they escalate—this episode is packed with the clinical gold you've been waiting for. Key Takeaways: Understanding MVX Plus: MVX Plus measures pivotal factors like Glyc A, small HDL particles, and branched-chain amino acids to offer a nuanced assessment of chronic diseases and longevity. Importance of B1: Dr. Schmidt underscores the critical role of Vitamin B1 in managing metabolic health and shares his dramatic recovery story from a gas leak-induced health crisis. Seven-Step Program: This comprehensive framework targets diet, energy, and detoxification to systematically improve health outcomes as indicated by MVX Plus results. Clinical Implications: Real-world examples emphasize how timely intervention based on MVX test results can dramatically affect a patient's health trajectory. Holistic Health: The episode advocates for a return to holistic practices and the understated value of nutrition, particularly protein-rich diets, in combating malnutrition. More About Dr. Darren Schmidt: Dr. Darren Schmidt, D.C. is the founder of the Nutritional Healing Center of Ann Arbor, the largest non-insurance nutrition clinic in the U.S. His 7-Step Blueprint to Optimal Health and MVX Plus blood test position him as a leader in root-cause foundational nutrition. He began practicing in 1997 and was early to adopt low-carb, keto, and carnivore—while always focusing on detox, nourishment, and restoring function. In 2005, he stopped accepting insurance to ensure clinical results weren't compromised. He has delivered over 100 seminars to 10,000+ healthcare professionals and continues to advance natural solutions for chronic disease. Website Instagram How MVX Can Help YouTube Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more!
Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses key health topics related to heart disease, which significantly impacts Australia. He emphasizes the importance of understanding blood pressure, weight, and cholesterol to improve health outcomes. The discussion highlights high-density lipoprotein (HDL), often labeled as "good cholesterol," noting that while higher levels are generally protective, some individuals with genetically high HDL may actually face increased heart disease risk if the HDL is not functional.
Story at-a-glance A study found that vegetarians who ate plant-based fake meat are 42% more likely to experience depression than those who don't, even when factors like age, BMI, and lifestyle are taken into account Eating fake meat leads to higher levels of C-reactive protein (CRP), a marker of systemic inflammation linked to chronic diseases like heart disease, diabetes, and autoimmune disorders Triglycerides were elevated and HDL cholesterol was lower in those eating fake meat, increasing their long-term risk for cardiovascular disease The body reacts to fake meat not because of its nutrients, but because of ultraprocessed ingredients and additives that disrupt immune signaling and metabolic function Even when blood nutrient levels appear normal, the deeper immune system activity reveals that fake meat is pushing your body toward inflammation and oxidative stress
PhD in synthetic chemistry, the Product Formulator for Supplement Needs, and fitness industry renowned Pharmacologist for his no-nonsense approach in bodybuildingThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program: https://www.nylenaygafitness.com2:19 Bodybuilding Pharmacology and Dosing4:53 Brain Health and Long-Term Risks7:29 Muscle Building and Genetic Factors10:03 Cholesterol and LDL Impacts12:14 Podcast Setup and Equipment Upgrades14:34 Hair Transplant Journey24:23 Hair Loss Causes and Treatments34:59 Post-Transplant Recovery and Rebound39:31 Epigenetics and Muscle Memory43:04 Ethical Questions on Genetic Enhancement45:40 Enhanced Games Debate50:09 Dosing Challenges in Enhanced Sports52:32 Data Collection and Human Experimentation55:16 Genetic Variance and Elite Athletes59:04 Neurodegeneration and PEDs1:07:08 Oxidative Stress in Bodybuilding1:09:37 Sleep and Brain Detox1:18:01 Nutrition for Oxidative Stress1:19:02 Melatonin as an Antioxidant1:21:13 Melatonin Dosing and Effects1:24:51 Melatonin and Sleep Support Supplements1:28:22 Magnesium and Sleep Health1:31:23 Sleep Apnea and Neural Health1:36:30 Frequent Urination at Night1:46:33 Overheating During Sleep1:59:14 Wrapping Up Oxidative Stress2:00:33 Neuron Loss and Neurotransmitters2:02:04 Boosting Brain Health with BDNF2:04:08 Peptides for Neural Growth2:09:14 Oxidative Stress and Supplements2:12:34 Neuroprotection Strategies2:19:56 EMF and Environmental Stressors2:22:12 Mitochondrial Dysfunction and Aging2:24:55 Balancing Oxidative Stress2:28:32 Steroids and Muscle Growth Rates2:38:54 HDL and LDL Control Ancillaries2:41:34 Statins and LDL Oxidation2:47:36 Antioxidants and Plaque Formation2:54:10 Balancing Cholesterol Levels2:58:35 CT Scans for Heart Health3:03:54 Heart Health Supplements3:06:48 Mitochondrial Stack Under 303:16:27 Balanced Diet in Prep3:20:24 Omega-3 and Fish Oil Quality3:23:36 Podcast Wrap-Up
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3012: Dr. Neal breaks down the role of genetics in cholesterol levels and explains how even those with a family history of heart disease can benefit from targeted lifestyle changes. From diet tweaks to exercise strategies, his practical tips empower listeners to take control of their heart health, no matter their DNA. Quotes to ponder: "HDL actually helps the body clear LDL from the arteries, which is why it's good." "One of the most effective ways to lower blood cholesterol and blood pressure quickly is weight loss." "Fiber is so helpful because it helps bind to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids (NIH Office of Dietary Supplements): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer USDA FoodData Central: https://fdc.nal.usda.gov/ National Heart, Lung, and Blood Institute: https://www.nhlbi.nih.gov Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3012: Dr. Neal breaks down the role of genetics in cholesterol levels and explains how even those with a family history of heart disease can benefit from targeted lifestyle changes. From diet tweaks to exercise strategies, his practical tips empower listeners to take control of their heart health, no matter their DNA. Quotes to ponder: "HDL actually helps the body clear LDL from the arteries, which is why it's good." "One of the most effective ways to lower blood cholesterol and blood pressure quickly is weight loss." "Fiber is so helpful because it helps bind to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids (NIH Office of Dietary Supplements): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer USDA FoodData Central: https://fdc.nal.usda.gov/ National Heart, Lung, and Blood Institute: https://www.nhlbi.nih.gov Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, Dr. Carolyn Moyers breaks down the latest original research from the April 2025 issue of Obstetrics & Gynecology, focusing on the long-term cardiovascular biomarker changes in women who participated in the Women's Health Initiative Hormone Therapy Trials. What does this mean for real-life patients considering hormone therapy? Are there age-related risks? What's the deal with triglycerides?Dr. Moyers explores the clinical relevance of these findings, limitations of the data, and the questions that still remain—offering an evidence-based, patient-centered perspective for women navigating menopause and their heart health.
Too busy to read the Lens? Listen to our weekly summary here! In this week's episode we discuss:Both high and low levels of HDL were associated with increased risk of AMD, though the mechanism for this remains unclear.A majority of ophthalmic subspecialists practice in urban areas, and this trend has increased over the last decade.Study compares 5 modern toric IOL formulas for cataract patients with astigmatism.Systemic GLP-1 inhibitor treatment was found to reduce size and leakage of CNVM lesions in mouse models.
Send us a textDr. Ankur Verma, an emergency medicine specialist from New Delhi and host of The DESI EM Project podcast, shares his compelling journey from a carb-heavy Indian diet to embracing a carnivore lifestyle after facing severe metabolic health issues. By adopting a meat-based diet, he reversed his own metabolic syndrome and witnessed remarkable health improvements in others, including his uncle's reversal of 25 years of diabetes. Dr. Verma challenges conventional nutritional wisdom by emphasizing the importance of biomarkers like triglyceride-to-HDL ratio and homocysteine levels over traditional cholesterol metrics. Through his podcast, he delves into topics such as emergency medicine, nutrition, and the influence of pharmaceutical interests on medical education, advocating for a root-cause approach to health. Follow his insights on Instagram @thecarnivore.epConnect with Ankur:@thecarnivore.epDesi EM Project - Spotify Desi EM Project - Apple Support the showPRIMAL FOUNDATIONS PODCAST-Instagram: @Tony_PrimalFoundationsWebsite: Primalfoundations.com The Strength Kollective: Download Kettlebell Programs (Click Here)Book a free 30 minutes consultation (Click Here)
Te explico todo sobre la famosa "triada cetogénica": colesterol LDL elevado, triglicéridos bajos y HDL alto, un patrón común en quienes siguen una nutrición cetogénica bien ejecutada. Detallo cómo esta triada, lejos de ser peligrosa, puede reflejar un estado metabólicamente saludable, especialmente cuando se acompaña de un bajo porcentaje de grasa corporal, buenos hábitos y una dieta rica en omega-3 y verduras. También hablo de los errores más comunes en la interpretación de analíticas y el uso excesivo de estatinas sin evaluar el contexto clínico del paciente.
Story at-a-glance Cholesterol is essential for hormone production, brain function, and cell health, and about 80% of it is made by your body — not consumed in food. High triglycerides, not total cholesterol, pose a stronger risk for heart attack — raising risk by 80% — making triglyceride-to-HDL ratio a better heart disease predictor Newer science shows chronic inflammation — not LDL alone — may be the real cause of plaque buildup in arteries, shifting focus to markers like ApoB and CRP Natural options like garlic, artichoke, bergamot, plant sterols, green tea, and oats have been shown in clinical studies to lower LDL cholesterol and improve heart markers Red yeast rice can lower LDL by up to 33%, but it contains a statin-like compound with the same side effects and potential kidney toxins like citrinin Lifestyle changes like cutting sugar, walking daily, and sleeping well can activate the Pareto Principle — where 20% of effort yields 80% of results in lowering cholesterol. Exercise improves five key metabolic biomarkers — glucose, HDL, triglycerides, blood pressure, and waist size — each linked to long-term cardiovascular health
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Kellie: Hi Dr. Cabral! I have been with your program for almost 6 months now. I have completed the Vit-Tox tests and have gone through the FM Detox twice and now going through the CBO Protocol. I just turned 38 years old and I feel like my joints are of an 80 year old. I have played soccer since age 5 and still play on a competitive coed league to this day. I have played many other team/contact sports in the past. I have had past ankle, knee, and hip injuries due to sports and I do see possible knee and hip replacements in my future. When I do my daily workouts or go up/down stairs my ankles, knees, hips, and back crack or pop so easily and so much. I don't see glucosamine chondroitin as a supplement in your shop. Are there any suggestions you may have to keep my joints healthier? Thank you!! Jon: Hey Dr Cabral, looking for advice and i feel like there's a population that struggles with this same topic. My Dr is recommending a statin due to my high LDL-C of 230. My LDL has gone up after cleaning up my diet in the last 7 months however ALL of my markers tested for have improved. Triglycerides have gone from over 200 to 100, HDL is up to 60, VLDL has dropped from 30 to 15, A1C is 5.2, blood pressure is normal for the first time ever, and so onr. My personal opinion is that i'm healthier than ever and i can't imagine having to go on what seems like a lifetime drug due to one marker being off and i don't buy the story that LDL alone is a concern for me. Curious on your opinion here and if you think i have something to worry about. Thanks!! Annette: I've been diagnosed with nephrocalcinosis by conventional doctors who say the cause is genetic. I have adjusted my diet to low sodium, low oxalate foods. The doctors say my next step is to try to get on the kidney transplant list before I need dialysis. I take potassium citrate and a calcitriol. Is there anything I can do to improve my kidney function? Summer: Hi Dr. Cabral! I heard you say that it's best to replace aluminum cookware, but not necessary, and instead to use parchment paper as a barrier. Doesn't the aluminum off gas when heated? How does parchment paper prevent the aluminum from getting into the food? Thanks! By the way, to all my fellow listeners: please contact your state representatives and let them know you do not consent to geo-engineering in your skies. Several states have now banned it. We could all live healthier lives if we could work toward eliminating toxins and heavy metals including aluminum that are regularly being sprayed into our air. Ann: Thank you Dr Cabral- you are changing SO many lives - thank you for all of your wisdom and teachings:) I have a question about Magnesium. My cortisol was high at my last lab test, and I took Full Spectrum magnesium for 12 weeks, and now I take Cal Mag daily. I also understand that I can take Calming Magnesium and CBD at night to help with sleep.I don't want to take too much for too long for my body, but I still think I need the help for my cortisol levels/ sleep. What combination of the above do you recommend? Is there a length of time that is too long to be on Full Spectrum Magnesium? PS. I do the 3-2-1 protocol, take Adrenal Soothe and will be repeating my big 5 this fall. Thank you again! Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/3396 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Send us a textDr. Adrian Soto-Mota is a returning guest on our show! Be sure to check out episode 138 of Boundles Body Radio, which was part of a special series we did, featuring Dr. Nick Norwitz as the guest host!We also hosted Dr. Soto-Mota on episode 340, episode 419, and episode 599 of our show!Dr. Soto-Mota is a MD PhD & Specialist in Internal Medicine and Data Science researcher at the Unidad de Investigación de Emfermedades Metabólicas! Dr. Soto-Mota is passionate about studying low carbohydrate and ketogenic diets, and how they impact human metabolism.Dr. Soto-Mota earned his MD from the Universidad Nacional Autónoma de México, and earned his Ph.D. at Oxford. He has created many resources to help people successfully implement a low carbohydrate diet, and provides that help for both English and Spanish speaking individuals.He is the co-author of a 2022 paper titled The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets, and the co-author of the recent paper titled Plaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025, both of which were also co-authored by former guests Dr. Norwitz and Dave Feldman, who we hosted in episode 109 of Boundless Body Radio!Find Dr. Soto-Mota at-TW- @AdrianSotoMotaPlaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025Keto Cholesterol study SHOCKS scientific community | LMHRs & heart disease from the Nutrition Made Simple YouTube ChannelAnalyzing the KETO-CTA Study with Dr. Gil Carvalho 813 on Boundless Body Radio!Discussing Keto-CTA with Darius Sharpe with Dave Feldman and Darius SharpeFind Boundless Body at- myboundlessbody.com Book a session with us here!
It's another week of answering listener questions! In this episode, we discuss: If carb depletion before a big race has any ground What it means if you have low HDL and what might be causing it Why you may be feeling nauseous mid-race and how to fix it Tips for avoiding all kinds of GI issues during training and racing Want to be featured on the show? Email us (written or an audio file!) at fuelforthesolepodcast@gmail.com. This episode is fueled by ASICS and RNWY!Head over to ASICS.com and sign up for a OneASICS account. It's completely free and when you sign up you will receive 10% off your first purchase. You also gain access to exclusive colorways on ASICS.com, free standard shipping, special birthday month discounts and more.We've been using RNWY collagen, protein and pre workout and loving it. Head over to https://rnwy.life/ and use code FEATHERS15 for 15% off your purchase. Disclaimer: This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Overview In this profoundly evocative episode of Higher Density Living, Jason Rigby welcomes Mary Reynolds Thompson, transformational coach and author of The Way of the Wild Soul Woman. Together, they traverse the barren landscapes and lush forests of the feminine psyche—inviting listeners into a mythic journey through the five sacred archetypes: Desert Woman, Forest Woman, Ocean/River Woman, Mountain Woman, and Grassland Woman. Mary masterfully unpacks how patriarchal systems fractured women's ancient bond with the Earth—and how reconnecting with nature's rhythms heals not only personal trauma but our planet itself. From honoring the barren stillness of solitude to embracing the spiraling growth of forest paths, this episode is a luminous guide for women and men alike to reclaim lost wisdom and embodied wholeness. Whether you feel disoriented in a hyper-masculine world or curious about the power of archetypes, this is a compass pointing home to your primal, untamed self. Timestamps 00:00 – Invitation to the Wild: Jason introduces Mary and the core premise of rewilding soul through Earth-based archetypes. 01:18 – What is the Wild Soul Story?: Mary defines a soul narrative rooted in Earth's psyche, inspired by Thomas Berry. 03:02 – Women & Earth: Shared Wounds: Discussion on patriarchal suppression of feminine and environmental wisdom. 08:15 – Desert Woman: The first archetype of solitude, silence, and shedding cultural roles. 13:12 – Forest Woman: Entering the spiral path of mystery, gestation, and inner transformation. 19:30 – Ocean & River Woman: Surrendering to emotion and trusting the current of longing. 26:06 – Mountain Woman: Manifesting bold purpose from inner knowing, unafraid of being seen. 29:47 – Grassland Woman: Re-entering the world with gifts and medicine, navigating return and reintegration. Quotes “We are not separate from nature—we are nature.” – Mary Reynolds Thompson “Stillness is rebellion in a culture of overdoing.” – Mary Reynolds Thompson “Your soul's longing is sacred—it's the compass back to your wild truth.” – Jason Rigby Resources Internal Higher Density Living Website HDL Meditation Archives Previous HDL Episode: “Earth Is Our Ancestor” External Mary Reynolds Thompson's Website Book: The Way of the Wild Soul Woman Book: Reclaiming the Wild Soul Thomas Berry's The Dream of the Earth Call to Action Feeling disconnected from your essence? It's time to rewild your soul. Subscribe to HDL, share this episode with someone craving reconnection, and explore Mary's meditations and writings. The Earth remembers who you are—return to her.
Exam Room Nutrition: Nutrition Education for Health Professionals
You've probably said it a hundred times: HDL is the "good" cholesterol, LDL is the "bad" cholesterol.But what if that explanation is oversimplified—and leading patients (and providers) to miss hidden risks?In this episode, I sit down with Dr. Josh Wageman—a Clinical Lipid Specialist, PhD researcher, and author of The Home Security System and the Lipid Neighborhood—to break down why the old-school lipid model isn't enough anymore, what a standard panel won't tell you, and how you can explain heart disease risk in a way that actually sticks with patients.If you've ever felt shaky explaining lipid panels, cardiovascular risk, or how diet ties in, this episode will give you a clearer framework—and practical tools you can use immediately with your patients.Resources:Buy the Book The Home Security System and the Lipid NeighborhoodConnect with Josh Episode 38 | Love Your HeartAny Questions? Send Me a MessageSupport the showConnect with Colleen:InstagramLinkedInSign up for my FREE Newsletter - Nutrition hot-topics delivered to your inbox each week. Disclaimer: This podcast is a collection of ideas, strategies, and opinions of the author(s). Its goal is to provide useful information on each of the topics shared within. It is not intended to provide medical, health, or professional consultation or to diagnosis-specific weight or feeding challenges. The author(s) advises the reader to always consult with appropriate health, medical, and professional consultants for support for individual children and family situations. The author(s) do not take responsibility for the personal or other risks, loss, or liability incurred as a direct or indirect consequence of the application or use of information provided. All opinions stated in this podcast are my own and do not reflect the opinions of my employer.
Your blueprint for navigating hormone shifts in your 30s, 40s, & 50s! In today's episode, integrative medicine physician Dr. Taz Bhatia talks about how to optimize hormones in your late 30s, what to do to support your liver and estrogen detoxification during perimenopause, and everything you need to know about starting hormone replacement therapy. We also answer your questions about lab work, signs of specific hormone imbalances, and unexplained midlife weight gain. This one has it all! Timestamps:[1:38] Noelle Intro[3:35] Welcome Dr. Taz [4:00] What's the latest research saying about women's health and hormones and what are you seeing actually work with your patients? [10:31] In your experience, what are the top things that women can do in their 30's to set themselves up for success in perimenopause?[14:40] Should we be looking at our numbers from testing and using that information to “optimize” them?[21:04] What's are the differences between the many hormonal shifts in our 30's?[26:47] What's a good repletion plan once we've been depleted due to stress, pregnancy or other things?[35:05] Do you think that women, as they enter perimenopause, should be regularly supporting the liver with herbs?[40:23] In perimenopause, what should I consider taking and what are the must dos? How do we know when it's time to start HRT?[42:12] Can you talk about the symptoms of low and high estrogen and progesterone? [44:35] How do you find a doctor that actually prescribes HRT? [45:25] I'm curious about when the right time is to get on HRT. Should I start it as a preventative measure or wait until I start experiencing symptoms? [46:39] What about HRT for people with the MTHFR mutation? [48:33] The change in body proportions have really played with my head. It's hard to feel healthy with an increase in midsection fat. How do I address this? [51:07] Is there any way to lower slightly elevated LDL cholesterol in perimenopause, even if HDL cholesterol is great? [51:30] Why do I feel terrible during ovulation? Episode Links:Hol+Follow Dr. Taz on InstagramThe Hormone Shift: Balance Your Body and Thrive Through Midlife and Menopause Super Woman Rx: Unlock the Secrets to Lasting Health, Your Perfect Weight, Energy, and Passion with Dr. Taz's Power Type PlansThe 21-Day Belly Fix: The Doctor-Designed Diet Plan for a Clean Gut and a Slimmer Waist Sponsors:Go to https://thisisneeded.com/ and use coupon code WELLFED for 20% off your first order.Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.Go to http://mdlogichealth.com/immuno and use coupon code WELLFED for 10% off.Go to wellminerals.us/chill and use code WELLFED to get 10% off your order.
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2972: Dr. Neal Malik breaks down the cholesterol puzzle, explaining the difference between "good" and "bad" cholesterol, and why not all dietary fats, or even dietary cholesterol, are created equal. Learn the six simple lifestyle changes that can naturally improve your cholesterol profile and reduce long-term health risks. Quotes to ponder: "Cholesterol actually acts as a transporter in the body, the precious cargo in this case: fat." "Fiber is like HDL's sidekick, it helps the body get rid of that lousy or lethal LDL cholesterol." "High intensity activity in particular seems to help increase the happy or healthy HDL levels in the blood." Episode references: American Heart Association - Cholesterol: https://www.heart.org/en/health-topics/cholesterol Learn more about your ad choices. Visit megaphone.fm/adchoices
Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2972: Dr. Neal Malik breaks down the cholesterol puzzle, explaining the difference between "good" and "bad" cholesterol, and why not all dietary fats, or even dietary cholesterol, are created equal. Learn the six simple lifestyle changes that can naturally improve your cholesterol profile and reduce long-term health risks. Quotes to ponder: "Cholesterol actually acts as a transporter in the body, the precious cargo in this case: fat." "Fiber is like HDL's sidekick, it helps the body get rid of that lousy or lethal LDL cholesterol." "High intensity activity in particular seems to help increase the happy or healthy HDL levels in the blood." Episode references: American Heart Association - Cholesterol: https://www.heart.org/en/health-topics/cholesterol Learn more about your ad choices. Visit megaphone.fm/adchoices
Presentación del caso – Motivo de consulta y contexto personalUna mujer de 42 años acude a consulta preocupada por su colesterol alto. Viene derivada tras una analítica en la que han detectado hipercolesterolemia leve, y ella cree que puede deberse a los “picoteos” que tiene por la tarde, que últimamente han ido a más. También quería trabajar su relación con la comida. Decía que por las tardes tenía una ansiedad desbordante, que se comía lo que fuera, sin hambre real. Se culpaba constantemente, se sentía fuera de control y con una enorme frustración porque siempre había sido muy consciente de su alimentación. Me cuenta que no entiende por qué le pasa, porque siempre ha comido bien, lleva una alimentación bastante equilibrada, y aunque no hace mucho deporte, se mantiene activa.Trabaja como administrativa en una empresa de seguros. Tiene dos hijos adolescentes, poco tiempo para ella y la sensación constante de que va a mil. Me explica que a media tarde llega a casa, cansada y con ansiedad, y que ahí es cuando arrasa con lo que pilla.Dice que duerme mal desde hace unos meses, que se despierta de madrugada sin motivo, que se nota más irritable y que últimamente le cuesta más concentrarse en el trabajo. También ha notado que su cuerpo ha cambiado: “Estoy más hinchada, me noto más barriga, aunque coma igual”, comenta.Le pregunto por su menstruación, y me dice algo muy típico: “Siempre la he tenido irregular, así que no sé… a veces me viene cada 40 días, a veces se me salta un mes entero, pero esto me pasa desde siempre”.Por eso, ni se plantea que lo que le está pasando pueda tener que ver con la menopausia.Desarrollo del caso – Qué vimos en consultaRevisamos su analítica.Efectivamente, hay una hipercolesterolemia, pero también aparecen otros datos que me llaman la atención:Déficit de vitamina D,Ferritina un poco baja,Magnesio en el límite inferior,Glucosa en ayunas un poco elevada,Y un perfil lipídico alterado, con un LDL elevado y HDL algo bajo.Con todo esto, y teniendo en cuenta la edad, los síntomas, el insomnio, el cambio en la distribución de la grasa corporal, la irritabilidad, la niebla mental y el déficit de vitamina D, empiezo a pensar en una posible perimenopausia.Se lo planteo, y se sorprende. “¿Tan pronto? Si todavía tengo la regla…”, me dice. Le explico que esta etapa puede comenzar años antes de la menopausia como tal, y que lo que le está pasando encaja perfectamente con ese perfil.Intervención – Cómo lo trabajamosEn consulta decidimos abordar el caso desde varios frentes:Alimentación:Adaptamos su pauta para favorecer el control del colesterol, pero también para mejorar su saciedad y estabilidad energética por la tarde.Añadimos más proteína en desayuno y comida.Trabajamos el equilibrio en las meriendas para prevenir los atracones y redujimos los azúcares simples.Incorporamos alimentos ricos en fitoestrógenos y omega 3.Relación con la comida:Exploramos el papel del picoteo como vía de escape ante el cansancio y la frustración.Introducimos estrategias de autocuidado emocional que no pasaran por la comida.Le ayudé a dejar de culpabilizarse y a comprender que no era falta de voluntad: era su cuerpo atravesando una transición.Ejercicio físico:Le recomendé ejercicios de fuerza dos veces por semana, empezando por rutinas sencillas en casa.Incluimos también caminatas diarias para mejorar su metabolismo, descanso y ánimo.Sueño y descanso:Ajustes de hábitos antes de dormir.Rutinas de relajación y revisión del entorno del sueño.Consideramos junto con su médico la suplementación con melatonina.Suplementación:Vitamina D, por el déficit evidente.Magnesio por sus beneficios en esta etapa (descanso, estado de ánimo, regulación hormonal).Omega 3 por perfil lipídico y efecto antiinflamatorio.Evolución y resultadosA las 4 semanas, ya notaba cambios:El picoteo por la tarde se redujo drásticamente.Dormía mejor.Tenía más energía durante el día.Se sentía menos culpable y más conectada con su cuerpo.Y lo más importante: empezó a reconciliarse con esta etapa, entendiendo que no era una enfermedad ni una derrota, sino un proceso natural que, con el enfoque adecuado, podía atravesar con bienestar.A los 3 meses, la analítica mejoró notablemente:Bajó el colesterol total y el LDL.Subió el HDL.Vitamina D dentro de rango.Y, además, había recuperado el control sobre su alimentación sin necesidad de restringir ni contar calorías.ConclusiónMuchas mujeres llegan a consulta preocupadas por su colesterol, su peso o su ansiedad por la comida, sin saber que lo que de verdad está ocurriendo es que han entrado en la perimenopausia.Y como no se lo han explicado, lo viven con culpa, confusión y soledad.Este caso nos recuerda la importancia de mirar más allá del síntoma y de acompañar esta etapa desde la comprensión, el respeto al cuerpo y un enfoque integral.Porque cuando entendemos lo que nos pasa, es mucho más fácil cuidarnos.Conviértete en un seguidor de este podcast: https://www.spreaker.com/podcast/comiendo-con-maria-nutricion--2497272/support.
Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the complexities of HDL cholesterol, often referred to as "good" cholesterol. He explains the roles of different types of cholesterol, specifically Apo B proteins associated with LDL cholesterol, which contribute to plaque formation and cardiovascular risk. While HDL is involved in transporting cholesterol back to the liver, its protective role is more complicated than previously thought.
Why You Should Listen: In this episode, you will learn about Metabolic Vulnerability Index (MVX) as an indicator of mortality and longevity. About My Guest: My guest for this episode is Dr. Darren Schmidt. Darren Schmidt, DC is the Founder of The Nutritional Healing Center of Ann Arbor which is the largest non-insurance nutrition clinic in the country. His purpose is to bankrupt pharmaceutical companies by teaching doctors how to improve health rather than treat symptoms. He uses new and old clinical discoveries to solve complex chronic illness with only diet and supplements. He uses MVX Plus, the best lab test to measure longevity and health, and it also directs the treatment plan. Key Takeaways: What is MVX? What are the 6 factors and 3 indices that are explored with MVX? How might MVX be a better metric for mortality than many conventionally-used metrics today? Can MVX be extrapolated to be used as a measure of health and longevity? What is GlycA? What drives it? What tools can be used to lower GlycA? What is the connection between GlycA and hypercoagulation? Why is eGFR and kidney health often used on the context of predicting mortality? What is small HDL particle number? How can it be optimized? What is the Inflammation Vulnerability Index? What is citrate? What tools can be used to lower it when elevated? What is the connection between citrate and mitochondrial function? What is lactic acidosis? What is learned from looking at valine, leucine, and isoleucine? What steps may be taken if they are high? If they are low? What is the Metabolic Malnutrition Index? When might a keto diet be appropriate? What does the Metabolic Vulnerability Index tell us? Is MVX impacted by genetics or epigenetics? What is the 7 Step Blueprint to Optimal Health? How do the 7 steps overlap with the 6 MVX factors? Connect With My Guest: TheNutritionalHealingCenter.com Related Resources: To see the resources in the Show Notes, visit https://BetterHealthGuy.com/Episode216. Interview Date: April 21, 2025 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode216. Additional Information: To learn more, visit https://BetterHealthGuy.com. Follow Me on Social Media: Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.
In today's episode of Barbell Shrugged you will learn: What are lipids What is cholesterol The difference between HDL and LDL cholesterol Why there is no such thing as “good” or “bad” cholesterol What are the bloodwork numbers for optimal cholesterol What is the perfect ratio of HDL and LDL Ratios for Triglycerides to HDL for optimal health Mechanisms for regulating cholesterol in the liver Why saturated fats are not bad and how your body uses them Cholesterols role in testosterone production To learn more, please go to https://rapidhealthoptimization.com Connect with our guests: Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram Dan Garner on Instagram
You hit 38, and all of the sudden the same stuff isn't working like it used to! So, what's going on? Dr. Mariza tackles the science behind weight changes in midlife, and how to build metabolic resilience and insulin sensitivity as you age. We also talk through lab work and how to make changes based on your blood work and symptoms. Perimenopause doesn't have to suck, and small shifts can completely change your life in the decades to come!Timestamps:[3:12] Interview with Dr. Mariza[3:26] What was the moment you knew you were in perimenopause? [7:03] What is happening to our hormones mid-life?[16:20] Where should women realistically start?[19:33] Are you ok with getting baseline markers in a blood test or is there a better way? [30:48] Is it normal for testosterone to be low and decline as women are in their upper 30s?[34:07] What is metabolic flexibility and how do you know if you actually have it?[37:03] Is there really a thing as being “in balance” with your hormones?[39:02] I'm curious about when the right time is to get on HRT - should I start it as a preventative measure or wait until I experience symptoms?[40:44] What should you test or do when you're doing everything right and still gaining weight? [47:16] How does blood glucose drive a change in fat storage and how can we improve that? [53:14] I am 41 and the same weight as last year but my middle is different - no change in diet or exercise, in fact I'm more disciplined than I've ever been. Help! [57:06] How do we combat burnout on all things “life” when there's no choice but to keep going?[1:04:34] Are you more sensitive to cortisol in mid-life and perimenopause and, if so, how?Episode Links:Visit Dr. Mariza's WebsitePerimenopause Survival GuideLab tests to run:Complete blood countComprehensive metabolic panel (should have fasting glucose included)Vitamin D3 – Needs to be 50+Fasting insulin - 5 or belowFasting blood glucose - 85 ml or lowerHemoglobin A1CC-Reactive Protein (CRP): Under 1Lipid panel: HDL above 50Apo B Test - under 85Uric acidHormonesCortisolFull testosterone panelFull thyroid panel Estradiol Progesterone Sponsors:Go to wellminerals.us/creatine and use code WELLFED to get 10% off your order. Launching April 1st!Go to http://mdlogichealth.com/mc and use coupon code WELLFED for 10% off.Go to https://thisisneeded.com/ and use coupon code WELLFED for 20% off your first order.Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.
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