POPULARITY
Categories
In this episode, I sit down with Doug Evans to make the case for the humble sprout as one of the most underrated foods for your heart. Most people push sprouts to the side of the plate as a garnish. Doug and I think that's a mistake.We talk about broccoli sprouts and sulforaphane, the plant compound that research has tied to the NRF2 pathway, glutathione production, and your body's own antioxidant and detox defenses. For me, that matters because oxidative stress and the health of your endothelium sit closer to the root of heart disease than the LDL and HDL numbers most cardiologists chase.Doug also walks through the practical side: which seeds to start with, why three-day-old sprouts are the most potent, how to tell healthy root hairs from mold, and why growing your own runs about a fifth of the grocery-store price. If you want one simple daily habit that lines up with how your body was actually designed to heal, this conversation is worth your time.- - - - -About the Guest:Doug Evans is the co-founder of The Sprouting Company and the author of The Sprout Book, a top-100 Amazon bestseller. A longtime pioneer in the natural-food world, he has spent more than thirty years championing whole, plant-based foods. After moving to the Mojave Desert and landing in a literal food desert, Doug began sprouting nearly all of his own food and turned that experience into a mission to make countertop sprouting simple, affordable, and accessible. He designed The Sprouting Company's growing kit and tracked down high-glucoraphanin broccoli seeds so anyone can grow nutrient-dense sprouts at home in days, without soil, sunshine, or fertilizer.Website: thesproutingcompany.comInstagram: @dougevans | @thesproutingcompanyBook: The Sprout Book- - - - -Jack Wolfson, DO, FACCWebsites: https://drjackwolfson.com/; https://naturalheartdoctor.com/LinkedIn: https://www.linkedin.com/in/drjackwolfsonReady to move past the confusion and fear of typical heart health approaches? Visit naturalheartdoctor.com/discovery to schedule your free discovery call and start your journey toward a 100-year heart with real, evidence-based answers.- - - - -PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/
Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Spike Proteins with Dr. Glenn, Beyond Cholesterol & Better Heart Testing with Dr. Dearing [0:00:00] – Intro: Brian Johnson, Longevity & Oxalates + Farmers Market Light banter about: Ed coining the term “peak span” and using it in interviews. Ed's social media success (8.3 million views in 90 days). Joking about Ed doing a shirtless video and his bodybuilding competition and carb loading. Ed talks about Brian Johnson (longevity guru who spends ~$2M/year trying to live to 120): Johnson recently announced an autoimmune condition where his stomach is “eating its own stomach.” Ed admires his data and “Blueprint” protocol but believes two key factors in Johnson's regimen contributed to this issue. Ed teases that one factor is excess oxalate-rich foods; the other factor is left as a teaser for Ed's social media video. Ed announces a weekly farmers market at Nutrition World: Every Wednesday, inside the store, morning to mid-afternoon. Run by a young family with clean farming practices and minimal chemicals. Nutrition World does not profit from it; framed as a service to the community and support for small farmers. [0:05:04] – Upcoming Guests, Ed's E‑Books & Podcasts Ed previews two interviews for this episode: Dr. Glenn – testing and managing spike proteins. Dr. Curt Dearing – discussing his new book “Beyond Cholesterol” and non-traditional views on cardiovascular risk. Ed's e‑books: Six e‑books available on theholisticnavigator.com, including: Quality sleep Oxalates and pain “Are You Sick and Tired?” (diet & overall health) Oral health Immune system “Core Four” foundational supplements Podcasts: Ed mentions his Holistic Navigator podcast Clint promotes Nooga Podcasts (noogapodcasts.com) – a network of 20+ podcasts. [0:09:26] – Interview with Dr. Glenn: What Are Spike Proteins & Why They Matter Dr. Glenn defines spike proteins: Discovered in the 1960s, normally part of viruses from nature. Our immune system usually recognizes and dissolves natural spike proteins. For COVID-era, lab-made spike proteins: They are not recognized properly by the body. They can persist and are not efficiently eliminated. Mechanism (simplified): Spike proteins interact with ACE2 receptors (“locks” on the cell door). They unlock and open the cell doors, enter the cells, and damage/destroy cells from the inside. Clint notes he never heard the term “spike protein” before COVID; Dr. Glenn explains: Previously, they weren't an issue because the body just handled them. This is the first time in history we've dealt with lab-made spike proteins at scale. Dr. Glenn stresses this is not simply vaccinated vs. unvaccinated: mRNA vaccines were designed to produce spike proteins. But unvaccinated people with bad cases of COVID can also carry very high spike levels. His personal story: Got severe COVID in Jan 2020, pre-official naming: 2 weeks very ill on couch/bed. 3 months to feel “recovered,” but that was just the start of long-term issues. Over the next 3+ years, progressive cellular damage accumulated, leading to a broad set of symptoms. Dr. Glenn's symptoms when spikes were very high: Whites of eyes turned gray, with burning eyes all day (constant eye drops). Tinnitus (ringing in ears). Cyclical rashes under armpits. Burning nerves in quads; needed leg massage devices nightly to sleep. Gout attacks (kidneys not handling uric acid well). Venous congestion in lower left leg. Severe fatigue, getting sick frequently despite doing everything “right.” Developed endocarditis (inflammation of heart and valves); resting heart rate jumped from 55–60 to 80–105. Subtle Bell's palsy–type weakness on left side of face and brain symptoms. Laboratory findings: Test: SARS‑CoV‑2 spike protein antibody test (semi-quantitative). Thresholds: 1000: likely too high, potential cell damage. 5000: “a whole other level of danger.” His highest result: 11,694 (measured around Oct 28, 2023). Progress over four tests: 11,694 → 11,087 → ~9,950 → 8,905 (as of June 30, current year). Many symptoms have significantly improved, though: Heart rate better but not back to baseline. Tinnitus persists. Spike level is still high, so work remains. Symptoms can vary dramatically from person to person: Because spikes can enter different “doors” (cells/tissues) in different bodies. One person's profile may be mostly neurological; another's cardiovascular, etc. Dr. Glenn's clinic policy: He will not work with someone on issues like hormones, gut, or cognitive problems without a spike antibody test, because: Otherwise they may be “paddling upstream” against ongoing spike-related damage. Observation: Many patients say: “My doctor says my bloodwork is fine,” yet they feel terrible. Conventional doctors rarely order spike protein antibody tests [0:23:01] – Managing High Spike Proteins: Testing, Risk & Protocol Who Should Test & How: Ed notes frequent COVID infections (he's had it six times) and that many people have unexplained symptoms. Both Ed and Dr. Glenn suggest: Spike antibody testing should be considered for anyone with mysterious chronic symptoms, regardless of age or vaccination status. Testing can be done through labs like Be Well Labs (which Nutrition World works with) or other local options. Reference values: < 0.08 means essentially no exposure to COVID. Out of ~130 tests Dr. Glenn has reviewed, only one person was
Imagine que o nosso corpo é como uma pequena cidade.Nessa cidade existem alguns personagens que, quando aparecem em excesso, podem causar problemas. Entre eles estão o colesterol ruim, o LDL, e os triglicerídeos. Eles acabam dificultando o trânsito nas nossas artérias, que são as estradas por onde o sangue circula.E bem no centro dessa cidade está o coração. É ele que mantém tudo funcionando.A boa notícia é que o nosso organismo também conta com um grande aliado: o HDL, conhecido como colesterol bom. Ele ajuda a retirar parte desse excesso de gordura da circulação e leva até o fígado, onde pode ser eliminado pelo organismo.Mas existe um jeito simples de fortalecer esse aliado.Mexa-se. Caminhe.Uma caminhada hoje pode parecer pequena, mas, feita com regularidade, ajuda a proteger o coração, melhora a circulação, contribui para o controle do colesterol, da pressão arterial, da glicose e ainda faz bem para a mente.Não precisa começar correndo. Comece no seu ritmo. O importante é começar.E junto com a caminhada, algumas escolhas fazem toda a diferença: diminuir o consumo de sal, açúcar, alimentos ultraprocessados e farinhas refinadas. Em compensação, colocar mais frutas, verduras, legumes, feijão, castanhas e alimentos naturais no prato.E a saúde não depende só da alimentação.Vale a pena cuidar também daquilo que alimenta a alma.Sorria mais.Valorize a família e os amigos.Cultive pensamentos positivos.Beba água antes de sentir sede.Descanse quando o corpo pedir.Faça seus exames regularmente.Tenha fé em Deus e nunca deixe de acreditar em você.Porque viver mais é importante.Mas viver bem é ainda melhor.Cuide do seu coração. Cuide da sua saúde. E, sempre que puder, dê o primeiro passo. Seu corpo agradece.
Imagine que o nosso corpo é como uma pequena cidade.Nessa cidade existem alguns personagens que, quando aparecem em excesso, podem causar problemas. Entre eles estão o colesterol ruim, o LDL, e os triglicerídeos. Eles acabam dificultando o trânsito nas nossas artérias, que são as estradas por onde o sangue circula.E bem no centro dessa cidade está o coração. É ele que mantém tudo funcionando.A boa notícia é que o nosso organismo também conta com um grande aliado: o HDL, conhecido como colesterol bom. Ele ajuda a retirar parte desse excesso de gordura da circulação e leva até o fígado, onde pode ser eliminado pelo organismo.Mas existe um jeito simples de fortalecer esse aliado.Mexa-se. Caminhe.Uma caminhada hoje pode parecer pequena, mas, feita com regularidade, ajuda a proteger o coração, melhora a circulação, contribui para o controle do colesterol, da pressão arterial, da glicose e ainda faz bem para a mente.Não precisa começar correndo. Comece no seu ritmo. O importante é começar.E junto com a caminhada, algumas escolhas fazem toda a diferença: diminuir o consumo de sal, açúcar, alimentos ultraprocessados e farinhas refinadas. Em compensação, colocar mais frutas, verduras, legumes, feijão, castanhas e alimentos naturais no prato.E a saúde não depende só da alimentação.Vale a pena cuidar também daquilo que alimenta a alma.Sorria mais.Valorize a família e os amigos.Cultive pensamentos positivos.Beba água antes de sentir sede.Descanse quando o corpo pedir.Faça seus exames regularmente.Tenha fé em Deus e nunca deixe de acreditar em você.Porque viver mais é importante.Mas viver bem é ainda melhor.Cuide do seu coração. Cuide da sua saúde. E, sempre que puder, dê o primeiro passo. Seu corpo agradece.
Welcome to a most informative and inspiring show about the amazing ancient superfood of cacao! This episode will give you everything you need to know about its remarkable health benefits, healing properties, and how to choose the most sustainable, eco-friendly, fair-trade bean-to-bar products. You will learn about the fascinating history of cacao as a sacred food, currency, and medicine, why it remains one of the most highly regarded superfoods on the planet, and how the food industry took this extraordinary raw material, stripped out everything useful, and transformed it into little more than a heavily sugared version of the original. Along the way, I explain the science in plain English—from the powerful polyphenols that support your heart, brain, blood pressure, gut microbiome, metabolism, and mood, to why cacao may be the single most antioxidant-rich food you can eat. I also reveal the disturbing reality behind much of today's commercial chocolate industry, including how mainstream processing destroys many of cacao's most valuable compounds and why ethical sourcing matters. You'll learn the difference between raw cacao powder, cacao nibs, and high-percentage dark chocolate, how to identify truly high-quality bean-to-bar chocolate, why I became a dark chocolate connoisseur, and the artisan brands I recommend. When this episode is over, you're never going to look at a chocolate bar the same way again, and you'll be fully armed to make the best product purchasing decisions and obtain the maximum benefits from consuming foods high in nutritious cacao. TIMESTAMPS: Cacao is one of the most highly regarded superfoods on the planet. [00:56] When you are finished listening to this episode, you will never look at a chocolate bar the same way again. [02:28] The best way to enjoy chocolate is to put it on your tongue and allow the flavor to dissolve in your mouth. [06:38] The history of cacao is fascinating. It is one of the most nutrient dense, biologically active foods in all of human history. [08:10] Early civilationa learned to ferment, roast, and grind cacao beans into a drink. It was more than a flavoring agent, it was very much a spriitual centerpiece as well as used for medicinal purposes. [10:11] After the Europeans added sugar to cacao, it lost some of its medicinal purpose, although it still is a good source of antioxidants. [12:29] There are many cardiovascular benefits from cacao. It improves platelet function. [18:17] Cacao has been shown in studies to produce meaningful reductions in both systolic and diastolic blood pressure. It is also known to help boost levels of HDL (high density lipoproteins.) [20:55] Cacao consumption improves your overall lipid profiles, including helping with healthy triglyceride levels. [27:24] Does cacao help with weight loss goals? [28:27] Cacao has an impact on brain function and mood. [31:37] In contrast to the powerful, hard and fast effects of caffeine, theobromine in cacao works more slowly. It has a gentler mechanism and a longer half life. [35:08] Studies show wonderful benefits from cacao on the gut. It has been identified as a potent prebiotic which is what feed probiotics to flourish in the intestinal tract. [38:59] Reasearch shows cacao has properties protecting you from UV damage from sunburn. [46:35] Just how damaging to health is mainstream modern chocolate processing? One of the terrible aspects of the low-priced chocolate is because of the support of child slave labor harvesting these beans. [50:02] Look for the designation of "bean to bar" on the product. It should also have cacao beans as the first ingredient. [55:05] In mainstream processing of the beans, they have to use super high temperatures which degrades the polyphenol. [57:17] There are three categories of products which can deliver these wonderful health benefits. [01:00:07] When the bar is above 80%, this is where most of the research showing cardiovascular cognitive benefits was conducted. The words "cacao beans" should be the first ingredient on the label. [01:05:53] Brad lists his recommendations for good chocolate bars. [01:19:44] How much chocolate should one consume? [[01:29:06] Do not refrigerate high quality dark chocolate. [01:32:50] LINKS: Brad Kearns.com BradNutrition.com B.rad Whey Protein Superfuel - The Best Protein on The Planet! Brad’s Shopping Page BornToWalkBook.com B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes B.rad Podcast – All Episodes Peluva Five-Toe Minimalist Shoes Burn The Primal Blueprint Podcast with Shawn Askinosie (Chocolate) Podcast with Todd White (Dry Farm Wine) Dry Farm Wines Askinosie Chocolate Chocovivo Cocoa Runners Nomosu Pump Street Chocolate Puna Chocolate Ranger Chocolate Rausch Spring and Mulberry We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn’t occupy this revered space. Seriously, I won’t promote anything that I don't absolutely love and use in daily life: B.rad Nutrition: Premium quality, all-natural supplements for peak performance, recovery, and longevity; including the world's highest quality whey protein! Get 20% OFF your first order! Peluva: Comfortable, functional, stylish five-toe minimalist shoe to reawaken optimal foot function. Use code BRADPODCAST for 15% off! Jaspr Air Scrubber: Ultra high-performance air purifier - blows other air filters away! Save $200 on your unit with code BRAD. Get Stride: Advanced DNA, methylation profile, microbiome & blood at-home testing. Hit your stride the right way, with cutting-edge technology and customized programming. Save 10% with the code BRAD. Online educational courses: Numerous great offerings for an immersive home-study educational experience Primal Fitness Expert Certification: The most comprehensive online course on all aspects of traditional fitness programming and a total immersion fitness lifestyle. Save 25% on tuition with code BRAD! #bradpodcastSee omnystudio.com/listener for privacy information.
If you've ever been told your high cholesterol is "just genetic" and there's nothing you can do but take medication, this episode is for you. I'm sharing the exact, research-backed changes that helped me drop my total cholesterol by 35 points, LDL by 27 points, and triglycerides by 80 points in 12 months, no medication required. As a Registered Dietitian and mom of 3, I'm breaking down the biggest high cholesterol myths (starting with the dietary cholesterol myth, yes, eggs are fine!) and walking through the lifestyle and nutrition shifts that actually move the needle on cholesterol naturally. In this episode, you'll learn: Why eating cholesterol-containing foods like eggs and shrimp isn't the real problem The truth about genetics and high cholesterol, predisposition isn't destiny How strength training and walking impact LDL, HDL, and triglycerides Why added sugar (not dietary fat) is one of the biggest drivers of high cholesterol The role of fiber in naturally lowering LDL cholesterol Cholesterol-supportive supplements to ask your doctor about: omega-3s, vitamin D, berberine, turmeric/ginger, plant sterols How blood sugar regulation ties directly into healthy cholesterol levels My personal before-and-after lab numbers after one year of consistency Disclaimer: This episode is for educational purposes and isn't a substitute for medical advice. Always talk to your doctor before starting supplements or adjusting cholesterol medication. Want pre-balanced meals that support healthy cholesterol without tracking or giving up your favorite foods? Join us inside Busy Mom Meals Come hang out with me on Instagram @nutrition.for.mamas
"The idea of metabolic scoring is to take guilt out of the picture. Because this is not anyone's fault. It's basically a cosmic shift in just our whole lifestyle here in Western civilization." — Dr. Ron HunninghakeIn this episode of the Real Health Podcast, Dr. Ron Hunninghake and Dr. Drew Rose discuss the complexities of metabolic syndrome, its prevalence in the Western world, and the lifestyle factors contributing to it. They emphasize the importance of identifying root causes and implementing personalized health strategies to combat this growing epidemic.
Wylecz Insulinooporność!---Witamy serdecznie w kolejnym odcinku! Przed Wami program pod patronatem Polskiego Towarzystwa Leczenia Insulinoporności, a nasz cel jest jeden: edukacja, bo zdrowie zaczyna się od wiedzy! W tym odcinku: · Błędne koło metaboliczne – jak nadmiar insuliny niszczy naczynia krwionośne, prowadząc bezpośrednio do nadciśnienia i miażdżycy.· 3 proste wskaźniki (Zamiast cholesterolu) – jak za pomocą HOMA-IR, trójglicerydów i HDL realnie ocenić ryzyko zawału.· Insulina a nowotwory – w jaki sposób hiperinsulinemia karmi guzy, stymuluje ich wzrost i przyspiesza starzenie komórkowe.· Pułapka lekowa (Ważne!) – dlaczego nagłe przejście na keto przy lekach na cukrzycę (np. Jardiance) wymaga ogromnej ostrożności i wiedzy. Wskakuj na naszą stronę https://braciarodzen.pl/wakacje-z-bracmi-rodzen/ i zapisz się do tej akcji czeka na Ciebie mnóstwo wiedzy slajdy oraz praktyczne prezenty. Słuchajcie nas regularnie we wtorki, środy i czwartki o 21:00. Subskrybujcie podcast, zostawcie łapkę w górę, udostępniajcie i do zobaczenia w kolejnym odcinku!--- Akcja Wylecz Insulinooporność! - pod patronatem: Polskiego Towarzystwa Leczenia Insulinooporności!https://ptli.pl/ ====Ważne: Nasz podcast może być emitowany z opóźnieniem w stosunku do odcinków na żywo. Promocje i informacje o wydarzeniach mogą być nieaktualne. Aktualne informacje znajdziesz na naszej stronie lub innych kanałach – linki poniżej.====Jeśli to, co robimy, jest dla Ciebie wartościowe, spraw, aby inni mogli to odkryć – udostępnij ten podcast i zostaw ocenę! ⭐⭐⭐⭐⭐ Twoja opinia ma znaczenie i pomaga nam docierać do kolejnych osób, które potrzebują tej wiedzy. Dziękujemy za Twoje wsparcie!Dołącz do NIEZALEŻNIE MYŚLĄCEJ i pięknie żyjącej społeczności
Get the 200+ Page Optimal Living Daily Workbook (PDF) — Free. Want to turn today's episode into an actionable plan? Join the Optimal Living Weekly newsletter and I'll send you our 200-page digital workbook immediately. It's packed with the best takeaways from the show, formatted for easy reading and implementation at home. Get your free PDF workbook here: https://oldpodcast.eo.page/join Discover all of the podcasts in our network, search for specific episodes and learn more at: OLDPodcast.com. Episode 3456: Sophie Szczudlo explores why foods like açaí, kale, quinoa, and chia seeds have earned the “superfood” label and explains that many ordinary whole foods offer similar nutritional benefits. Rather than chasing trendy ingredients, she emphasizes that a varied diet of fresh, minimally processed foods is what truly supports long-term health. Read along with the original article(s) here: https://idealnutrition.com.au/the-hype-about-superfoods/ Quotes to ponder: "The key is to eat a variety of fresh wholefoods so that all food groups can work in synergy to benefit your overall health." "Goji berries are allegedly able to boost immunity and brain activity and protect against cancer." "Omega-3 can aid in fighting inflammation and can help reduce the risk of developing cardiovascular disease by raising the HDL or the ‘good cholesterol' in our blood." Learn more about your ad choices. Visit megaphone.fm/adchoices
Get the 200+ Page Optimal Living Daily Workbook (PDF) — Free. Want to turn today's episode into an actionable plan? Join the Optimal Living Weekly newsletter and I'll send you our 200-page digital workbook immediately. It's packed with the best takeaways from the show, formatted for easy reading and implementation at home. Get your free PDF workbook here: https://oldpodcast.eo.page/join Discover all of the podcasts in our network, search for specific episodes and learn more at: OLDPodcast.com. Episode 3456: Sophie Szczudlo explores why foods like açaí, kale, quinoa, and chia seeds have earned the “superfood” label and explains that many ordinary whole foods offer similar nutritional benefits. Rather than chasing trendy ingredients, she emphasizes that a varied diet of fresh, minimally processed foods is what truly supports long-term health. Read along with the original article(s) here: https://idealnutrition.com.au/the-hype-about-superfoods/ Quotes to ponder: "The key is to eat a variety of fresh wholefoods so that all food groups can work in synergy to benefit your overall health." "Goji berries are allegedly able to boost immunity and brain activity and protect against cancer." "Omega-3 can aid in fighting inflammation and can help reduce the risk of developing cardiovascular disease by raising the HDL or the ‘good cholesterol' in our blood." Learn more about your ad choices. Visit megaphone.fm/adchoices
GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption. Source: https://www.nature.com/articles/s43856-026-01566-x ~~ GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy. Sources: https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498 https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds ~~ Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk. Source: https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn ~~ Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost. Sources: https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/ https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/ ~~ Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations. Source: https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/ ~~ New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, and in mouse studies, strawberries reduced colitis activity only in mice with an intact microbiome. Host Dave Asprey explains why the plant itself isn't the active ingredient, your bacteria are, and connects the findings to this year's Environmental Working Group Dirty Dozen and Clean Fifteen lists to help listeners decide where organic actually matters. Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC12768975/ https://www.eurekalert.org/news-releases/1108351 https://www.nature.com/articles/s41564-025-02197-z ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into the gut-brain axis, an underreported GLP-1 side effect, a global parasite hiding in plain sight, the real ROI of exercise on mental health, consolidation in the supplement industry, and how your microbiome determines what your produce actually does for you. Host Dave Asprey connects clinical research, large cohort studies, mechanistic biology, and industry news into practical frameworks for improving gut health, brain performance, and long-term resilience. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: plasma acetate gut brain axis, short chain fatty acids, gut microbiome cognition, GLP-1 smell taste disturbances, anosmia parosmia GLP-1, semaglutide side effects, toxoplasmosis neglected tropical disease, Toxoplasma gondii health risks, congenital toxoplasmosis, exercise mental health study, exercise versus income happiness, overtraining mental health, Unilever Thorne acquisition, supplement industry consolidation, phytonutrient gut bacteria enzymes, polyphenol metabolism microbiome, Dirty Dozen Clean Fifteen 2026, pesticide residue produce, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Story #1: Acetate & Gut-Brain Health 01:57 – Story #2: GLP-1s & Smell/Taste Loss 03:22 – Story #3: Toxoplasmosis Risks 04:33 – Story #4: Exercise vs Income 05:53 – Story #5: Phytonutrients & Gut Enzymes 07:45 – Dirty Dozen & Clean Fifteen 08:46 – Story #6: Thorne Acquisition 09:49 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dr. Leah Petrucelli, a family medicine physician at Jamaica Hospital Medical Center with training in integrative medicine and nutrition, breaks down LDL, HDL, cholesterol testing, and cardiovascular risk in plain language. Learn about cholesterol management, lifestyle changes, cholesterol diet basics, and when a cholesterol test or statin might be recommended. For appointments or more resources, visit jamaicahospital.org.
Brian has been on a carnivore diet for almost 4 years. He was very overweight most of his adult life. In 2018, he developed A-Fib, and was having 2-3 paroxsymal A-Fib episodes per week before starting carnivore. Lower back and hip pain were so bad that he couldn't sleep longer than a couple of hours in bed at night. Brian also struggled with low energy, mild depression, joint pain, arthritis in his big toe, high triglycerides, low HDL, and low vitamin D. Within a few weeks on carnivore Brian was sleeping all night in bed, joint pain was going away, and he noticed A-Fib episodes were not happening. He lost 60 pounds in the first 3 months and 85 pounds over the first year and has maintained that weight loss since starting carnivore in July of 2022. Brian has gone over 3 1/2 years without a single A-Fib episode. His cardiologist has had him wear a heart monitor multiple times, including once for 30 days, and participate in a stress test and ultrasounds, showing no evidence of going into A-Fib anymore. In November of 2025 Brian had a CAC scan and it was 0. His HDL is improved and triglycerides are way down. His Vitamin D level is normal, and no longer has issues with joint pain or arthritis in the big toe. Starting carnivore at age 48, Brian is now 52 years old and feeling better than he did in his 30's. Socials: YouTube - @wickivore Timestamps: 00:00 Trailer 00:22 Introduction 05:52 Increasing joint flare-ups 08:07 First heart diagnosis 09:41 Struggles with restrictive dieting 12:49 Discovering the Carnivore Diet 15:58 Discussing keto-friendly foods 20:48 Carnivore diet and joint health 24:30 Finding a flexible doctor 28:35 Personal transformation and health concerns 32:09 Positive changes after diet switch 35:13 Early days of carnivore diet 37:54 Carnivore diet's growing popularity 41:45 Impact of Joe Rogan on Diet Trends 43:41 Avoiding unhealthy products Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs #Revero #ReveroHealth #shawnbaker #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.
It's In the News - a look at the top diabetes headlines and stories happening now. Our top stories: More information about type 1 and COVID, including the vaccine, why is the latest GLP-1 medication, not yet FDA approved, showing up all over the place, what table sugar and vinegar could mean for drug costs, a new inhaled insulin study and much more I'll see you at Friends for Life next week. Come find me at Table T18 Learn more about our in-person events here: https://diabetes-connections.com/events/ Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Transcript & links: Okay.. our top story this week: XX A large Swedish study found that the increased risk of being diagnosed with type 1 diabetes after COVID-19 infection is mostly limited to the first 30 days after infection and does not continue long term. Researchers followed nearly the entire Swedish population under age 80 from 2020 through 2023 and found that while SARS-CoV-2 infection was linked to a temporary rise in new type 1 diabetes diagnoses, the risk declined over time. The study also found no evidence that COVID-19 vaccination increases the long-term risk of developing type 1 diabetes. Vaccination did not significantly change the relationship between COVID-19 infection and diabetes risk, and any small increase in diagnoses seen among adults shortly after a first vaccine dose was not seen after later doses or during longer follow-up. The researchers concluded that their findings do not support changing current COVID-19 vaccination recommendations because of concerns about type 1 diabetes risk. https://www.infectiousdiseaseadvisor.com/news/covid19-infection-may-increase-short-term-type-1-diabetes-risk/ XX Two new studies are challenging the traditional view that type 1 diabetes develops solely because the immune system attacks insulin-producing beta cells. Researchers from Indiana University found evidence that beta cells themselves may play an active role in determining whether they survive or succumb to the stresses that lead to type 1 diabetes. In the first study, scientists discovered that some healthy human beta cells can quickly activate an antiviral defense system when exposed to interferon-alpha, an immune signal often produced during viral infections. This response relies on molecules called reactive oxygen species (ROS), which are usually associated with cell damage but, in this case, appeared to help switch on protective antiviral genes. Researchers found this defense program in healthy cells and in people at risk for type 1 diabetes, but not in beta cells from people who already had the disease. The findings suggest that losing this built-in defense mechanism may make beta cells more vulnerable during the development of type 1 diabetes. The second study focused on autophagy, the process cells use to recycle damaged or worn-out components. Using a new imaging technique, researchers observed that beta cells in a mouse model of type 1 diabetes showed defects in autophagy before blood sugar levels began to rise and even before a full immune attack was underway. This suggests that problems inside the beta cells may occur early in the disease process rather than being caused entirely by the immune system. Together, the studies point to a more complex picture of type 1 diabetes. While they do not show that beta-cell defects cause the disease, they suggest that differences in how beta cells respond to stress, viral signals, and cellular damage may influence who develops type 1 diabetes and how the disease progresses. https://medicalxpress.com/news/2026-06-beta-cells-players-diabetes.html XX Researchers have created the most detailed map yet of how the human pancreas develops during childhood, offering new clues about why children are especially vulnerable to developing diabetes. The study, published in Nature Communications, examined pancreatic tissue from 123 children without diabetes, ranging from newborns through age 10. Using advanced imaging techniques, scientists tracked how insulin-producing islet cells grow and mature during the first decade of life. The researchers found that pancreas size varies dramatically at birth, with some infants having pancreases nearly four times larger than others. They also discovered that insulin-producing beta cells grow more slowly after birth than previously thought, suggesting that much of a person's lifelong beta cell capacity may be established before birth and during early childhood. Other findings showed that insulin-producing cells mature earlier than glucagon-producing cells and that new hormone-producing cells may continue to form after birth. The researchers hope this new understanding of pancreas development will help scientists identify diabetes risk earlier and develop better strategies for prevention and treatment in children. https://news.vumc.org/2026/06/29/unlocking-diabetes-secrets-pediatric-organ-donors-help-map-a-path-to-a-cure-and-prevention/ XX At the American Diabetes Association annual meeting, 2-year results from the SUPPRESS-EARLY trial showed that initiating tirzepatide (Mounjaro, Zepbound) early in the course of type 2 diabetes led to substantially higher rates of near-normal glycemic control and also led to broader metabolic improvements compared with intensive conventional therapy. In this MedPage Today video, investigator Stefano Del Prato, MD, of the University of Pisa in Italy, discusses the findings. Following is a transcript of his remarks: What happened is that in the tirzepatide-treated arm, 85% of the population at the end of the second year was on the maximum dose of tirzepatide 15 mg. And then the remaining 15 with the different doses. Interestingly, in the population that had been treated with the intensive conventional approach, 85% of them ended up to have, on top of metformin, a GLP-1 receptor agonist, mainly represented by subcutaneous semaglutide [Ozempic, Wegovy], 60+%, another 15% on oral semaglutide [Rybelsus], and the remaining on dulaglutide [Trulicity]. And I have to say that maybe the recommendation to really push along the line to try to achieve and to strive to achieve [glycemic] control was successful in these individuals. Because the population that had been recruited in the study started off with a baseline A1C of 7.8% and it went down to 6.3% in the conventionally intensive treatment, which is not bad at all, on average is below the target of 6.5%. However, when we look at the effect of tirzepatide, the final level of A1C at the end of the second year was 5.6%, which is on average below the upper limit of the normal range for A1C, 5.7%. This also translates into more people not only achieving normal glycemia, if we can define normal glycemia as A1C below 5.7%, greater than what we observed in conventionally treated individuals. So it was around three times more people achieving an A1C of 5.7%, in the range of around 65%, as compared to 28% with people on a conventional optimized treatment. Now, this is not surprising knowing the potency of tirzepatide. But again, going back to the rationale of the design, can we change what is the natural history of the disease? This seems to be at least of interest and it's possibly changing the trajectory of the disease for glycemic control, as I mentioned, but also in terms of the body weight and waist circumference because both body weight and waist circumference went much lower with tirzepatide compared to the conventional treatment. Tirzepatide also was associated with an improvement in the lipid profile, in particular with the LDL, triglycerides, and the triglyceride concentration and non-HDL cholesterol, and also with a statistically significantly lower systolic blood pressure with a numerical reduction in the diastolic blood pressure. And also the other thing that probably will ... become more apparent with the study continuing is that the investigators were allowed to add on any other treatment ... needed to achieve their target. So tirzepatide was just metformin and tirzepatide. In the control group, there was already 10% of people who were receiving two drugs on top of the metformin. So another potential result of the trial is that it's possible to achieve and maintain better glycemic or better metabolic control over the time without really needing to increase the number of medications in order to achieve that goal. And we know that type 2 diabetes is a progressive condition often requiring intensification of the treatment. So these initial results really stand for a great opportunity with tirzepatide. Of course, we need to wait for the 4 years just to confirm that this is indeed the case, but the initial result seems to point along that line. https://www.medpagetoday.com/meetingcoverage/adavideopearls/121967 XX A study from the University of Virginia found that high blood pressure is extremely common among people with diabetes, even among those who believe their blood pressure is under control. Researchers measured blood pressure in 172 adults with type 1 or type 2 diabetes during routine eye clinic visits and found that only 8% had normal readings. About half had stage 2 hypertension, and more than 10% had blood pressure levels high enough to be considered a medical emergency. The study also revealed that many patients were unaware of how serious their blood pressure problems were. Among those who thought their hypertension was well controlled, more than half still had stage 2 hypertension. Nearly 60% of participants were advised to contact their primary care provider, and one patient required an emergency department referral. Most patients supported blood pressure screening during eye exams, leading researchers to suggest that routine blood pressure checks in ophthalmology clinics could help identify undiagnosed or poorly controlled hypertension before it leads to serious complications such as heart attack, stroke, or worsening diabetic eye disease. https://medicalxpress.com/news/2026-06-routine-eye-exams-reveal-stage.html XX What is going on with retatrutide? This is the next generation GLP-1 but it's not authorized outside of clinical trials. Big investigation by CBS shows retatrutide is for sale all over the internet, a phenomenon they say has no modern precedent. CBS News identified more than 120 websites selling or promoting retatrutide, including more than 50 clinics staffed by licensed medical professionals. After being contacted by CBS News, at least 21 clinics abruptly removed retatrutide from their websites or changed the language to state they don't offer it. Others defended prescribing it, saying they're confident enough in results from clinical trials sponsored by drugmaker Eli Lilly that they didn't need to wait for the FDA's independent, rigorous review. An FDA spokesperson said retatrutide "has not been found safe or effective for any condition," adding that it "cannot be manufactured or distributed except for investigational use." The Justice Department is prosecuting two cases – in Utah and Florida – involving the sale and prescription of retatrutide. But the first line of enforcement is often at the state level. Ohio's Board of Pharmacy has taken action against several pharmacies and clinics providing retatrutide, and just last month, Alabama's Medical Board warned physicians against prescribing research-grade medications. The FDA has sent 14 warning letters to companies that have advertised retatrutide since 2024. Of these, at least six have continued to offer it online, including a business called Pink Pony Peptides. A TikTok account associated with the firm responded to the warning in April by taunting the FDA, boasting that the business "just had the best 24 hours ever." In May, Eli Lilly announced that participants in a large clinical trial taking the highest dose of retatrutide lost an average of 28% of their body weight over 80 weeks. Side effects – including nausea, diarrhea, constipation and vomiting – were comparable to similar therapies, the company said. "Anyone purporting to sell retatrutide to consumers is breaking the law," an Eli Lilly spokesperson said https://www.cbsnews.com/projects/2026/experimental-weight-loss-drug/ XX Pioneering research has developed a new way of creating carbohydrate-based medicines, which could ultimately replace costly drugs for common health conditions, using two cheap basic ingredients – table sugar and vinegar. These medications include SGLT2 inhibitors, widely prescribed drugs used to treat type 2 diabetes, heart failure and chronic kidney disease. Co-lead author Professor Phil Baran, Dr. Richard A. Lerner Endowed Chair at Scripps Research, in San Diego, California, said: "The point of this is to show that anyone in a garage can make an SGLT2 inhibitor with reagents that are widely available. We have not patented this method, so we welcome any generic drug company – or anyone else – who wants to use it to help bring costs down for patients." https://www.newswise.com/articles/new-study-shows-table-sugar-could-hold-a-cheaper-quicker-key-to-making-vital-drugs-for-diabetes-heart-failure-and-chronic-kidney-disease XX England and Wales approve teplizumab to slow progression of T1D. At the moment, the Scottish Medicines Consortium does not have an appraisal of Tzield on the go, so, there is likely to be a disparity in access within the UK for the time being. In Northern Ireland, access will depend on a review and adoption of NICE guidance. Sanofi is expecting to see an uptick in momentum thanks to two subsequent FDA approvals, one in children as young as one with stage 2 T1D, and a second to delay the decline in endogenous insulin production in children aged eight to 17 years recently diagnosed with stage 3 T1D. btw you might here more people referring to stage 4 diabetes. They've added that to include people diagnosed with type 1 who've been on insulin for a longer period of time – basically long enough to not be eligible for the current guidelines for Tzield. https://www.bbc.com/news/articles/ce8mzd94r76oXX XX Obesity Association, a division of the American Diabetes Association® (the association), announced the next section in the Standards of Care in Overweight and Obesity, "Screening, Diagnosis, Evaluation, and Staging of Obesity in Adults," published in Diabetes, Obesity, and CardioMetabolic CARE® and BMJ Open Diabetes Research & Care. Key highlights of the guidance: Early screening: Annual BMI screening with emphasis on tracking weight trends to identify risk earlier, including a longitudinal life-event weight graph tool for standardized assessment. Enhanced diagnosis: Combines BMI with waist measurements and population-specific thresholds to improve accuracy. Notably, the guidelines recommend that BMI in the overweight range together with central adiposity measurements warrant a formal obesity diagnosis. Comprehensive evaluation: Holistic assessment including medical, behavioral, and social factors. Offers a fully integrated obesity diagnostic algorithm. Risk stratification: Use of tools like the Edmonton Obesity Staging System to guide care. Chronic care approach: Ongoing monitoring and follow-up to support long-term management. Reducing bias: Promotes person-centered, non-stigmatizing care and system-level improvements at the clinical workflow level and encourages screening for prior weight bias/stigma experiences. https://www.prnewswire.com/news-releases/new-standards-of-care-in-overweight-and-obesity-section-screening-diagnosis-evaluation-and-staging-of-obesity-in-adults-302809670.html XX Dexcom (Nadsaq:DXCM) today announced the launch of its fully reimagined Stelo over-the-counter (OTC) sensor app experience. San Diego-based Dexcom plans to formally begin the new app rollout in July for Apple iPhone and Android users in the U.S. Dexcom said its reimagined app aims to make glucose insights easier to understand and act on. It hopes to help build awareness of how food, activity, sleep and stress influence overall wellbeing. The company also reiterated plans to launch Stelo internationally. It expects to bring the sensor to the UK, Australia, New Zealand and South Korea later this year, continuing into 2027. https://www.drugdeliverybusiness.com/dexcom-launches-enhanced-stelo-app/ XX MannKind Corporation recently announced it received a grant from Breakthrough T1D to support the INHALE-1 clinical study of Afrezza, its ultra rapid-acting inhaled insulin, in newly diagnosed pediatric type 1 diabetes patients aged 10 to under 18 years. This external funding for a trial focused on early use of Afrezza in children highlights growing third-party support for inhaled insulin in pediatric diabetes care. https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-mnkd/mannkind/news/afrezza-pediatric-trial-grant-might-change-the-case-for-inve XX Alexander Zverev heads into Wimbledon with plenty of momentum. The French Open champion returns to the All England Club looking to build on his first Grand Slam title and gain ground on Carlos Alcaraz in the race for the No. 2 spot in the ATP rankings. Zverev has an opportunity to make up points quickly after a first-round exit at Wimbledon last year. But his final tune-up before Wimbledon came with an unexpected challenge. During his semifinal loss to Taylor Fritz at the Halle Open, Zverev said a malfunctioning glucose sensor led to serious diabetes management issues on court. The sensor incorrectly showed his blood sugar was high when it was actually low, causing him to take more insulin than needed. "I had huge problems with the sugar because the sensor I use gave me a completely incorrect reading," Zverev said after the match. "During the match, or rather during the first 45 minutes, I had to consume about 350 grams of sugar. I felt absolutely terrible." Despite feeling unwell, Zverev pushed the match to three sets before falling 6-7(4), 6-4, 7-5 to Fritz. He credited his opponent with playing the better match and said the diabetes-related issue was not an excuse for the result. Zverev, who was diagnosed with type 1 diabetes at age 4, uses Medtronic diabetes technology to help manage his glucose levels while competing on the ATP Tour. He said the sensor error was the first major problem he has experienced after nearly a decade of using the technology. The German said the incident should not affect his Wimbledon preparations. With the sensor issue behind him, Zverev will begin his Wimbledon campaign focused on adding another strong result to what has already been a breakthrough season. https://www.reuters.com/sports/tennis/zverev-says-glucose-sensor-malfunction-affected-halle-semi-final-loss-fritz-2026-06-21/
“Physical activity is really such a linchpin in being able to change the trajectory of how you age.” — Dr. Susan Brian “Resistance training is probably your most proactive tool under your control for trying to reduce your risk of developing metabolic syndrome.” — Dr. Jocelyn Wittstein Key Links & Resources Subscribe to Age Better Cheat Sheet on Substack HERE Follow Barbara Hannah Grufferman on Instagram HERE Follow Dr. Susan Brian on Instagram HERE Follow Dr. Jocelyn Wittstein on Instagram HERE Episode Summary Metabolic syndrome is not one single disease. It's a cluster of warning signs — including waist size, blood pressure, triglycerides, HDL cholesterol, and blood sugar — that together can tell a much bigger story about your health. And for women in their 60s, this matters because metabolic syndrome is not just about lab numbers. It can affect your risk for type 2 diabetes, heart disease, fatty liver disease, sleep apnea, inflammation, bone health, muscle quality, mobility, and physical capacity. In this episode of AGE BETTER, I talk with two leading physicians: Dr. Susan Brian, a board-certified endocrinologist and menopause specialist, and Dr. Jocelyn Wittstein, an orthopedic surgeon and sports medicine specialist at Duke. Together, they explain why metabolic syndrome becomes more common after menopause, how visceral fat and insulin resistance can affect the body, and why this issue is deeply connected to how strong, mobile, energetic, and independent you feel as you age. You'll learn: What metabolic syndrome is and why having three of the five key markers matters Why insulin resistance is often at the center of the pattern How menopause can shift fat storage toward more visceral belly fat Why metabolic health and musculoskeletal health are closely connected How metabolic syndrome can affect muscle, bone, joints, stamina, and frailty risk Why muscle is so important for blood sugar control Why walking, strength training, and “starting somewhere” can make a real difference What to ask your clinician if you think you may have metabolic syndrome or be heading in that direction Where GLP-1 medications may fit for some women — and why strength training matters if weight loss is part of the plan The big takeaway: metabolic syndrome is not just about weight. It's about how your body is functioning — and the earlier you recognize the pattern, the more opportunity you have to change the trajectory. Dr. Brian encourages women to know their numbers, advocate for themselves, and figure out what kind of physical activity they can do consistently. Dr. Wittstein emphasizes resistance training, starting where you are, and building the right team around you — because protecting muscle, bone, mobility, and strength is central to aging better. Calls to Action If this episode helped you, please follow or subscribe to AGE BETTER wherever you listen to podcasts. Share this episode with a friend, sister, partner, or anyone who wants to stay strong, healthy, and independent as they get older. And make sure you subscribe to Age Better Cheat Sheet on Substack, where I go deeper into the newest research on healthy aging and break down what it means for you. Have an idea for a future episode or a question you want answered? Email me at agebetterpodcast@gmail.com.
Are you worried about your cholesterol levels on your labs continuing to climb? While conventional medicine bloodwork typically focuses on total cholesterol, LDL, and HDL, these markers don't always provide a complete picture of cardiovascular risk. The good news is there's a more accurate marker called ApoB that can offer deeper insight. On today's show, I want to break down what ApoB is, why it matters more than traditional cholesterol markers, and the 7 most effective ways you can naturally lower it. Tune into today's Cabral Concept 3786 to learn how to lower your ApoB naturally and support long-term heart health through simple, foundational lifestyle changes. Enjoy the show, and let me know your thoughts! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3786 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Most of us assume that if we look healthy on the outside, our heart is fine on the inside, but today, preventive cardiology dietitian Michelle Routhenstein explains why that's exactly the assumption that gets women into trouble, especially through perimenopause and beyond. We get into the two numbers your doctor probably isn't checking, ApoB and Lp(a), the first five diet changes Michelle makes with clients to bring down high cholesterol numbers, why stretching may be doing as much for your arteries as it does for your joints, and why blood pressure, not HRV, deserves far more of your attention as you move through this life stage. WHAT YOU'LL LEARN ● Why heart disease can silently progress in women who look and feel healthy ● What ApoB and Lp(a) actually measure, and why they matter more than LDL and HDL alone ● The first five diet changes to lower high ApoB or non HDL cholesterol ● Why saturated fat, fiber, and gut health all influence your cholesterol numbers ● Why blood pressure, not HRV, deserves more of your attention in perimenopause ● How menopause hormone therapy really affects your cardiovascular risk ● The minerals your heart needs to keep beating and pumping properly TIMESTAMPS 00:00 Heart Disease Risk in Women: ApoB, Lp(a), and the Tests Your Doctor Isn't Running 10:18 The Hidden Inflammation Driving Your Heart Disease Risk (And How to Test for It) 19:29 The Truth About Saturated Fat and Cholesterol After 40 22:19 The First Five Diet Changes to Lower High ApoB or Non HDL Cholesterol 29:24 Bloating, Gut Health and Thyroid: The Hidden Heart Disease Risks in Perimenopause 39:41 Why Stretching Might Be Protecting Your Arteries, Not Just Your Joints 51:48 Does Menopause Hormone Therapy Actually Protect Your Heart? VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.
Are you worried about your cholesterol levels on your labs continuing to climb? While conventional medicine bloodwork typically focuses on total cholesterol, LDL, and HDL, these markers don't always provide a complete picture of cardiovascular risk. The good news is there's a more accurate marker called ApoB that can offer deeper insight. On today's show, I want to break down what ApoB is, why it matters more than traditional cholesterol markers, and the 7 most effective ways you can naturally lower it. Tune into today's Cabral Concept 3786 to learn how to lower your ApoB naturally and support long-term heart health through simple, foundational lifestyle changes. Enjoy the show, and let me know your thoughts! - - - For Everything Mentioned In Today's Show: StephenCabral.com/3786 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Are eggs bad for you because they may raise cholesterol?It's one of the most common nutrition questions in cardiology, and one of the most misunderstood. The reality is that raising cholesterol and harming your health aren't always the same thing, and when it comes to eggs, the data tells a much more nuanced and reassuring story than most people have been led to believe.In this conversation, Dr. Bret Scher walks through the science of eggs, cholesterol, and cardiovascular risk, cutting through decades of nutritional confusion to help you understand what it actually means for your individual dietary choices.You'll learn:Why the original "eggs cause heart disease" logic doesn't hold up under scientific scrutinyWhat happens to LDL and HDL when most people eat whole eggsWho the "egg hyper responders" are and what genetics has to do with itWhy hazard ratios in observational egg studies are often clinically unhelpfulWhat the American Heart Association now says about eggs and cardiovascular riskWhy eggs are one of the most nutrient dense whole foods availableHow to think about egg quality, quantity, and individual responseThe takeaway: eggs can be part of a healthy whole foods dietary pattern for most people. Context, metabolic health, and the totality of your diet often matter far more than any single food.
Matthew "Oki" O'Connor is the CEO of Scientific Affairs at Cyclarity Therapeutics, a clinical-stage biotech building a new class of medicines designed not to slow the accumulation of vascular damage but to reverse it. Oki and Chris first crossed paths as postdocs at Lawrence Berkeley National Lab in the mid-2000s — Oki was in Irina Conboy's lab, not far from the late Judy Campisi's group, where Chris was then working on cellular senescence. After Berkeley, Oki spent nearly a decade running the research program at the SENS Research Foundation, the organization most identified with the "damage repair" framing of aging biology, before co-founding Cyclarity (then known as Underdog Pharmaceuticals) in 2019 to translate one of SENS's most drug-tractable ideas into an actual molecule.When Oki was last on the show in March of 2023 (Episode 36), Cyclarity was deep in IND-enabling work and its lead asset, UDP-003, had only ever seen the inside of a mouse artery. At the end of that conversation, Chris asked what Oki hoped to be discussing the next time he visited. He answered, bluntly, that he wanted to be presenting human data. Last month, at the AHA Vascular Discovery Sessions, Cyclarity reported the results of their first-in-human Phase 1 trial of UDP-003 — a designed cyclodextrin that selectively binds 7-ketocholesterol, the oxidized cholesterol species that drives foam cell formation and arterial plaque. He's back to discuss what the drug actually did when it went hunting for 7KC inside a living human being.In this episode, Chris and Oki cover the unmet need that lipid-lowering drugs — statins, PCSK9 inhibitors, the coming Lp(a) agents — still don't address: none of them remove the damage already sitting in an artery wall. Oki explains the basic chemistry of 7-ketocholesterol and why macrophages, lacking the machinery to recycle it, collapse into foam cells and seed the necrotic core of advanced plaque. They walk through the engineering of UDP-003 as a dimeric beta-cyclodextrin "double cone" tuned for a single oxidized cholesterol species, the design of the 72-volunteer Australian Phase 1, and the exploratory pharmacodynamic readout that has the field's attention: dose-dependent urinary excretion of 7KC, stoichiometric with drug, cleared within a day. The conversation then turns to the 150-patient Phase 2 plan in coronary artery disease patients with plaque imaging as the primary biological readout, the funding math that stands between Cyclarity and that trial, the platform's reach into NASH, vascular dementia, AMD, and aging itself, and how all of this descends from the SENS damage-repair philosophy that Oki has been carrying since LBL.The Finer Details:- Why current standard of care is not enough — statins, PCSK9 inhibitors, GLP-1s, and the soon-to-arrive Lp(a) lowering agents all act by slowing the accumulation of arterial damage, not by reversing what's already there; despite 30 years on the market, statins have never demonstrated an all-cause mortality benefit in a clinical trial, and even the best statin imaging data shows only 1–2% plaque volume regression at very high doses in a subset of patients- The scale of the problem — atherosclerosis is estimated to contribute to roughly 40% of all human deaths once heart attack, stroke, and a surprisingly large COPD contribution are risk-adjusted in, on top of an enormous morbidity tail that includes angina, peripheral artery disease (up to and including amputation), and a growing case for vascular dementia as an undercounted driver of cognitive decline- The biology of 7-ketocholesterol — when an oxygen free radical reacts with cholesterol, it preferentially attacks the 7 position, and a second oxidation step locks the molecule into 7KC, a stable toxic species cells were essentially never equipped to recycle; it builds up in long-lived cells like macrophages, eventually shutting down their ability to traffic lipids back to the liver via HDL and converting them into foam cells that seed soft plaque and, over years, the necrotic core of advanced lesions- The molecular design of UDP-003 — cyclodextrins are naturally occurring carbohydrate rings; the beta size fits half a cholesterol molecule, and Cyclarity's in silico work showed that two beta-cyclodextrins facing wide-side to wide-side form a "double cone" that can fully encapsulate a single cholesterol; engineered correctly, that wrapper can be made selective for 7KC over native membrane cholesterol, which is what gives the drug its therapeutic window- The Phase 1 trial design and result — a traditional 72-volunteer safety study in Australia, split between single ascending dose and multiple ascending dose arms, escalating up to six doses at what Cyclarity believes will be the efficacious level; no serious adverse events, no bioaccumulation, drug excreted essentially completely in the urine (as predicted preclinically), and — the headline exploratory endpoint — dose-dependent urinary 7-ketocholesterol appearing on the same timescale as the drug, consistent with one molecule of UDP-003 binding one molecule of 7KC and leaving the body together- What the urinary 7KC readout can and cannot tell you — the easiest 7KC to mobilize is the free pool in circulation, but there is not nearly enough of it floating in the bloodstream to account for what came out in urine, which means the drug is reaching deeper compartments; how much is coming from vessel wall plaque versus liver versus other peripheral tissues will require the imaging endpoints of Phase 2 to answer- The Phase 2 plan — 150 coronary artery disease patients (the coronary being, as Oki puts it, the artery most likely to kill you), with baseline plaque imaging, a year of dosing, and a repeat scan; safety and PK continue, inflammatory biomarkers come on, and plaque volume change is the prize — for context, a 1% change in plaque volume is associated with roughly a 20% change in next-year risk of heart attack or stroke- The funding math and the platform — Cyclarity has raised $33M to date and needs roughly $45M more to run the Phase 2, with Phase 3 cardiovascular outcomes trials running into the hundreds of millions and likely requiring a pharma partner; beyond atherosclerosis, 7KC is elevated in NASH livers, in Alzheimer's brains, and in the retinal cells that die in age-related macular degeneration, and the underlying chemistry — designed binders that drag a specific toxic molecule out of the body — is meant to generalize into a pipeline against other accumulated damage species, the direct intellectual descendant of the SENS damage-repair programQuotes:"Atherosclerosis, or the plaque that builds up in your blood vessels in your arteries, is estimated to cause approximately 40% of all human death.""When [the macrophage] eats up too much oxidized cholesterol, it just accumulates it… And that's when you get this transition to these kind of monster blob cells called foam cells.""One molecule of our drug is supposed to bind one molecule of 7-ketocholesterol and then go away and never be seen again. You excrete both of them together.""A 1% change in plaque volume is associated with a 20% risk in the next year of your probability of having a heart attack or a stroke.""You pick one target at a time, you do it well, and you take it all the way to the clinic and hopefully prove that you can actually cure patients, help them get better, help their plaque shrink away, and prove that this approach can work."Links:Cyclarity Therapeutics: https://cyclarity.com
Send us Fan MailNearly a decade after the last major cholesterol guidelines were released, the new 2026 Multi-Specialty Lipid Guidelines introduce significant changes in how cardiovascular risk is assessed and managed. In this episode, Albert Lopez, DO, FACP, FASPC, explains why LDL cholesterol treatment goals have returned, how newer markers such as ApoB and Lipoprotein(a) are reshaping risk assessment, and why earlier, more aggressive treatment may help reduce the world's leading cause of death, cardiovascular disease.Dr. Al Lopez, DO, discusses the role of statins, non-HDL cholesterol, triglycerides, genetic cholesterol disorders, screening recommendations for children and older adults, and the importance of a team-based approach to prevention. Whether you're a healthcare professional or someone interested in protecting your heart health, this episode provides a practical overview of the latest evidence-based recommendations for preventing heart disease.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!
In this eye-opening episode, Dr. Scott Watier and Tommy Welling challenge the idea that the number on the scale is the best measure of metabolic progress, revealing why fasting is less about making the scale move and more about why it's moving. They break down the critical difference between being metabolically healthy at a higher weight versus metabolically at-risk at a normal weight, and why BMI alone misses the full picture. The hosts walk through five key markers to track alongside fasting — waist circumference, fasting glucose and insulin, triglyceride-to-HDL ratio, blood pressure, and visceral fat indicators — and explain how each one reflects real metabolic healing that the scale simply can't show. Listeners will come away understanding why consistency with fasting windows and simplified, protein-forward food choices accelerates cellular healing far more than chasing a daily weigh-in number. As a challenge this week, Dr. Scott and Tommy encourage listeners to measure their waist-to-height ratio, pull their most recent labs, and set one new scoreboard metric to track their true metabolic progress. Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting! Resources and Downloads: SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! SLEEP GUIDE DIRECT DOWNLOAD DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE! Partner Links: Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 25% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Our Community: Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://www.levels.com/blog/what-can-weight-tell-you-about-your-metabolic-health
This week we talk about LDL, HDL, and cardiovascular issues.We also discuss one-time therapies, statins, and pharmaceutical economics.Recommended Book: Blood by Dr. Jen GunterTranscriptCholesterol is the most common type of what's called a sterol, which is a type of steroid, but also structurally technically an alcohol. But functionally, and classified by scientists, cholesterol is a lipid, which in this case is similar to a fat in all but how the body uses it. Cholesterol is the type of sterol most commonly found in animals—other types are found in plants and fungi—and its function, and this is where it varies from fats, which are used to store energy, is to basically help hold the cell membrane together, and it also serves as an intracellular messenger.Cholesterol is especially prevalent in the brain and spinal cord of animals, but it's found throughout their bodily tissues, as well, and again, it's vital for holding everything together and helping things communicate, in addition to being a precursor for vitamin D, steroid hormones, and bile.You want to have cholesterol, then, as without it you would be dead.Too much cholesterol in the blood, however, can also make you dead, especially when it's bound to what's called low-density lipoprotein, or LDL, as that contributes to cardiovascular disease like heart attacks and aneurysms, which can massively impact one's overall wellness and quality of life, and at extremes lead to the whole system shutting down as a consequence of heart attack, stroke, and the like.A lot of things can contribute to the development of cardiovascular disease, including habits like smoking, genetic predisposition, and the enthusiastic consumption of alcohol and unhealthy foods. But high blood cholesterol, of the LDL variety, is one of the top contributors, as these low-density clusters of lipoprotein can clog the pathways that blood takes throughout our bodies. Other, denser types of lipoproteins, HDLs, can clear it, like a heavier, denser substance pushing through clogs of less-dense materials that are gumming up a pipe, but LDL is at times accumulated as a result of consuming delicious but unhealthy foods, which are hard to avoid, and for some people the only consistently available and affordable foods; and for other people LDL accumulates as a result of their genetic predispositions—two things that are devilishly difficult to change.What I'd like to talk about today is a new type of therapy that may be very good news for people who struggle with the accumulation of LDL, and why this is being seen as very good news more broadly, at the scale of entire nations, as well.—Pharmaceutical company Eli Lilly is testing a new, experimental drug called VERVE-102 which is a one-time infusion that is currently administered over the course of about four hours, and once completed, it turns off a gene called PCSK9, which is responsible for making a protein that regulates cholesterol levels in humans.As I said, this drug is still being tested, so these are early results. But in a study of 35 people with high cholesterol levels, high levels of LDL or LDL-C, which is short for lipoprotein cholesterol, they found that this infusion, which again, is a one-time treatment, so get it once and then theoretically at least you never have to get anything done ever again, it reduced those LDL and LDL-C levels by as much as 62%, and that reduction was maintained a year and a half after the infusion; that's how far out they're retested so far, and the hope is that each retest will continue to show the same.On the strength of those very promising results, a Phase 2 study has been planned by the end of 2026, and the US Food and Drug Administration, the FDA, previously fast-tracked this existing study, because of the promise and potential this drug already demonstrated in early studies; all of which is considered to be very significant progress and possibility.To understand that significance, though, it's useful to know some health stats. And I'm going to focus on the US here, as that's where this drug is being developed, but many wealthy countries have similar stats, at least in terms of cardiovascular disease struggles.As of 2024, which is the last year we had good, cohesive data on this in the US, it was estimated that about 11-12% of the US adult population has high cholesterol levels. This typically doesn't come with any symptoms, but it can contribute a higher risk for all those cardiovascular diseases, including heart attack and stroke. A further 86 million US adults have borderline or elevated cholesterol levels, which can easily tip higher, but also, even in that existing, elevated state, contribute to negative cardiovascular outcomes.There are treatments for high cholesterol, the most common of category of which are called statins, which reduce the production of LDL by inhibiting an enzyme that produces cholesterol in the body.Unfortunately, these drugs do come with some usually minor side effects, which can cause patients to stop using them, and they have to be taken daily, ideally at the same time each day. That necessity for consistency leads to a lot of incorrect or incomplete usage, which reduces the effectiveness of these drugs. But it's also estimated that only about 54.5% of US adults who would benefit from statins are currently taking one—so that's people who could benefit and who have it prescribed, and then within that number are all the people who are taking this drug incorrectly or incompletely, reducing the effectiveness. So a relatively small number of people who should probably be on these things are getting the full benefit they offer because of the nature of the drug.And that's not great, because in the US alone, heart disease is the leading cause of death for pretty much every adult demographic; men, women, people of most racial and ethnic and economic groups, you name it, heart disease is the biggest threat to their lives.One US citizen dies every 34 seconds of some kind of cardiovascular condition, and as of 2023, 1 in every 3 deaths in the US was caused by the same, adding up to just over 919,000 people that year.Between 2021 and 2022, alone, the cost of services and medications related to heart disease added up to more than $168 billion; again, that's just in that period, and just in the US.And once more, these are ailments that are caused or heavily influenced by high levels of cholesterol, which are themselves amplified by common lifestyle choices, environmental factors that are hard for many people to avoid, and just by raw, dumb luck because of genetics.This treatment category, then, is being seen as a pretty big deal because a one-time infusion means those who receive it don't have to remember to take a pill every day at the same time, and won't experience those statin-based side-effects.It also means that people who are currently costing the medical system a bunch of money each year, because they need treatments for all the issues they suffer as a result of high cholesterol, will suddenly cost the system a lot less money, for treatments and medications. Not for nothing, their health and quality of life will likely improve as well. So in addition to having better, healthier outcomes personally, their cost to healthcare systems will drop.Eli Lilly's drug isn't the only one currently working its way through clinical trials, either.Amgen is working on a similar treatment, and Novartis and Ionis Pharmaceuticals have drugs that are even further along in the process, their medicines that cut heart attacks, strokes, and cardiovascular deaths could be approved by the FDA as soon as next year.There are a lot of caveats worth noting here, including that the science is still out as to whether this approach, silencing proteins that lead to the creation of more LDL and a similar substance called Lp(a)—which is more dangerous because it's stickier and thus more likely to get stuck in important blood pathways, and it's also more likely to be caused by genetics than lifestyle—the word is still out on whether reducing these things in the body actually reduces hearth attacks and stroke.Some people have had this particular risk variable dramatically reduced, but have still suffered from cardiovascular events, which raises the question of whether this path is the right one to take in trying to reduce this category of health issues; the correlation between LDL and heart attacks and strokes might not be a clear-cut as long assumed.There's also the issue of price. Drug-makers are economically incentivized to sell treatments over cures, because that means they can continue selling their product over time, potentially for the life of the patient, and a cure, in contrast, is a one-time hit that in theory should alleviate the need for future treatment.There's a chance, then, that the drug-makers will decide they need to make these one-hit treatments really, really expensive in order to make their R&D dollars back and to make the kinds of profits their investors expect from them. That could then reduce the potential audience for these treatments, even if they are effective, and could further slow their deployment and future research in this space.If these trials continue to go well, though, there's a good chance that this combination of similar but distinct treatment types will provide a more sustainable alternative to current options, and that, like the recent bogglingly rapid and widespread deployment of GLP-1 treatments for all sorts of issues, could lead to a new paradigm in this facet of the medical world.Show Noteshttps://en.wikipedia.org/wiki/Cholesterolhttps://en.wikipedia.org/wiki/Cardiovascular_diseasehttps://en.wikipedia.org/wiki/High_cholesterolhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10982736/https://www.cdc.gov/heart-disease/data-research/facts-stats/index.htmlhttps://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1https://www.ama-assn.org/public-health/chronic-diseases/what-doctors-want-patients-know-about-high-cholesterolhttps://en.wikipedia.org/wiki/Statinhttps://pubmed.ncbi.nlm.nih.gov/42187087/https://abcnews.com/GMA/Wellness/new-drug-game-changer-people-high-cholesterol/story This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe
Hosts: Ed Jones (Owner of Nutrition World) & Clint Powell A variety of topics all to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: All about Eggs & Pasture Raised Chickens with Kristy, Deprescribing & “De-Supplementing” with Dr. Curt Dearing [0:00:00] Intro, Nutrition World Updates, and Ed's Bodybuilding Prep Ed announces a new partnership with Azure: Bringing ~100 new holistic food items into Nutrition World. Examples: maple syrup, coconut oil, apple cider vinegar, organic chicken breast, cheeses, farm butters. Ed shares he's preparing for the Chattanooga Fitness Bodybuilding Contest (his 4th year): Being coached by Matt Davis (Train Station gym). Current approach: high protein, ~40% fewer calories, focused fat loss. Matt had him do a high-carb refeed day (~300g carbs vs his usual 50g) which dramatically improved his energy and look. [0:9:11] Protein, Longevity, and Why Ed Focuses on Eggs Ed emphasizes a higher-protein diet, especially for aging, muscle maintenance, and longevity. Core diet elements he advocates: Higher protein Healthy fats Colorful vegetables (in smaller but consistent amounts) Notes many women under-consume protein, which accelerates muscle loss and impacts longevity. Introduces guest Kristy, a long-time friend and staff member who homesteads and raises eggs that Ed eats 12–18 per week. [0:11:04] Homesteading with Kristy: How She Raises Chickens and Protects the Flock Kristy's setup: Around 100 chickens, plus goats, dogs, cats, and a donkey (Bradford). Lives “on the prairie” (rural, wooded property). Uses no chemicals on the property (no weed killers, pest sprays, etc.). She wants chickens to “do chicken things”—roam, peck, eat bugs, move soil—rather than be treated like pets or indoor animals. Predator control: No perimeter fence; previously lost some chickens to a fox attack. Now uses Bradford the donkey and a Great Pyrenees dog for protection: Donkey alerts and deters daytime predators like hawks and owls (stomping and loud calls). Pyrenees patrols at night, primarily deterring coyotes. Roosters herd hens into cover when threats appear. Motivator: Kristy's passion for knowing where her food comes from, and controlling at least part of her family's food system. [0:15:09] Structured Water, and Animal Hydration Kristy filters all animal water with a high-grade system (not just a basic fridge filter): Removes contaminants without completely stripping all minerals (not full RO). Then she “restructures” the water with a swirling device (structure unit): Mimics water flowing over rocks in nature, believed to add “life” and energy back to the water. She and Ed both report feeling better hydration from structured water (less persistent thirst). All of her animals receive this filtered/structured water. [0:17:26] Egg Production, Breeds, and Why Yolk Color Matters Kristy keeps multiple chicken breeds: Shell color = breed, not nutrition (white, brown, cream, etc., are just different breeds). Example: White Leghorn → white eggs, Rhode Island Red → darker brown eggs. Key nutritional indicator: yolk color She aims for deep orange yolks. Pale yellow yolks signal lower nutrient density, especially protein and nutrient intake from the chickens' diet. Production basics: Most hens lay about 5–6 eggs per week, especially in their first 3 years. Ed and Clint estimate she's getting hundreds of eggs per week in total. Kristy's flock policy: She has a “no-kill” policy for older hens, keeping them for tick and bug control and the social flock structure. Acknowledges some people cull flocks after 2–3 years, but she tends to keep productive, healthy hens past 4 years. [0:19:37] Industrial Eggs vs. Pasture-Raised: Animal Welfare and Nutrition Ed contrasts Kristy's setup with CAFO operations (Concentrated Animal Feeding Operations): Chickens crowded in small cages, poor conditions, bad feed. Notes such operations often use antibiotics—partly for disease, but also because they fatten animals. Kristy's holistic management: No antibiotics; uses natural anti-parasite and immune support: Pumpkin seeds for worms Homegrown herbs like oregano and rosemary She builds a strong “terrain” (internal environment) in the animals so they resist disease better. Discussion that what chickens eat (seed oils, moldy grains, etc. in industrial systems) ultimately affects the nutritional quality of the eggs humans eat. Nutritional highlights of eggs: Choline in yolks (brain and cognitive health). A “perfect protein” with high biological value and broad micronutrients. Eggs historically rank at the top for turning dietary protein into muscle due to a complete amino acid profile. Cholesterol discussion: Ed challenges the blanket fear of cholesterol: Cholesterol supports hormone production and brain function. Notes that the real risk markers are advanced lipoproteins like ApoB and Lp(a), not total cholesterol alone. Personal example: Ed eats 12–18 eggs per week. & his cholesterol is extremely low by clinical standards. Conclusion: Quality eggs are encouraged, especially from pasture-based systems like Kristy's, or higher-quality options in stores. [0:23:15] “Organic” vs. “Pasture-Raised” and Misleading Egg Labels “Organic eggs”: fed organic feed but may still be confined indoors with no outdoor access. “Pasture-raised”: hens are outdoors on pasture, doing natural chicken behaviors; often superior in welfare and nutrition. Both agree: If forced to choose, pasture-raised is preferable to organic-only. They call out labels bragging about “vegetarian-fed” hens as misleading: Chickens are not natural vegetarians; they're omnivores that eat bugs. Forcing a vegetarian diet moves them away from their natural food and may reduce egg quality. Kristy shares a quirky but natural behavior: Chickens love scrambled eggs as a treat. She feeds them scrambled eggs and crushed shells. Rationale: Eggshells are rich in calcium, which hens need to build strong new shells. She simply cracks and throws shells; no elaborate processing.. [0:27:25] Refrigeration vs. Room-Temperature Egg Storage Kristy's explanation: Freshly laid eggs have a “bloom” or natural protective coating that makes them shelf-stable if not washed. Unwashed farm eggs can sit at room temperature for ~6 weeks or more. Store-bought eggs are washed and must be refrigerated, because washing removes that protective coating. You cannot safely leave standard grocery-store eggs on the counter. Ed highlights this as another example of nature's built-in protective design. [0:32:28] Deprescribing and “De-Supplementing” with Dr. Curt Dearing Ed reintroduces Dr. Curt Dearing to expand on a prior show about deprescribing (reducing excessive medications). Common scenario Curt sees: People on many prescription meds plus a large number of supplements, overwhelmed and confused. They want to simplify, optimize, and know what really matters. Curt's consult approach: Review all meds and all supplements, then: Remove what isn't necessary. Emphasize foundational lifestyle and core supplements. They warn about a false sense of security: Some people think “I'm taking a pill, so I don't have to change my habits.” This applies to both pharmaceuticals and nutraceuticals. [0:36:00] The Core Four, Lifestyle First, and Limits of Medication-Only Approaches Ed references his “Core Four” foundational supplements (detailed in a free ebook on The Holistic Navigator): Designed as tier 1 essentials vs. lower-tier “nice-to-have” supplements. Curt's stance: Diet and exercise are the primary pillars. Supplements should support, not replace, healthy habits. Example: People on metformin or berberine may keep eating poorly yet feel “covered” because their blood sugar numbers look better. This is managing symptoms, not addressing root causes. [37:15] “Beyond Cholesterol” and Advanced Heart Risk Testing Curt mentions his upcoming ebook “Beyond Cholesterol” (targeting Amazon release): Argues standard lipid panels (total cholesterol, LDL, HDL) are not enough. Advocates for advanced tests like ApoB, Lp(a), and coronary calcium scores. Example case: A patient with LDL of 212 on atorvastatin. Curt notes that LDL alone can be “dangerous or harmless” depending on the underlying particle types and inflammation. Coronary Calcium Score: Patient's score is 0, which is reassuring but not a free pass. Calcium score detects calcified plaque, not soft plaque, and doesn't capture inflammation. Curt emphasizes HS-CRP (high-sensitivity C-reactive protein) as a marker of systemic inflammation, which drives soft plaque formation. [0:40:22] Medications in the Case Study: Statin, Nexium, Amlodipine, Zoloft Curt walks through a specific patient on multiple meds: Atorvastatin (statin) Curt questions its necessity given: Calcium score of 0 Lipid values that don't look catastrophic Recommends advanced lipid testing and provides patients with evidence-based reasons to discuss with their provider if they want to stop. Nexium (PPI) Discusses risks of long-term proton pump inhibitor use: Impaired absorption of magnesium, calcium, micronutrients Possible cognitive, kidney, and bone issues. Insists on a taper, not cold turkey, due to rebound reflux. Amlodipine (blood pressure med) Often can be tapered fairly quickly, especially when: Lifestyle changes are implemented (diet, exercise). Magnesium intake is optimized (many people take too little magnesium). Curt's view: conventional medicine often drives blood pressure too low in older adults; some elevation is physiologically adaptive. Zoloft (SSRI) Must be tapered, like most psychiatric meds, to avoid withdrawal and symptom flare. [0:46:10] Magnesium, Omega-3s, and Simplifying the Supplement Stack Curt reviews the patient's supplement list and simplifies: Multivitamin: Advocates a high-quality multi (not basic synthetics like Centrum). Prefers one that already includes CoQ10 (e.g., 100 mg), so separate CoQ10 can be discontinued. Vitamin D: Should be taken with vitamin K to direct calcium into bone and away from arteries and organs. Omega-3s: Many people take half the necessary dose. Recommends triglyceride-form omega-3s like DHA Extra (~960 mg DHA) for inflammation and blood pressure. Magnesium: Suggests glycinate or taurate forms for better absorption and blood pressure benefits. Probiotics: Curt suggests taking breaks (e.g., a month off) and rotating brands/strains, including spore-based types. Seasonal products: The patient takes quercetin + stinging nettle for allergies. Curt recommends seasonal use only for seasonal allergies, saving money and reducing pill fatigue. For lipids and blood sugar, Curt favors BerberCol (berberine + bergamot) to: Improve numbers (to satisfy doctors). More meaningfully affect ApoB and related risk markers. Weight & energy: Patient had been using weight-loss products. Curt shifts focus to fixing sleep and overall lifestyle rather than stacking more “fat burners.” Saffron: He distinguishes between saffron extracts for mood vs. saffron for weight management—formulation details matter. [0:54:57] Closing: Funding for Alternative Health and Supplement Tax Benefits Ed shares policy/legislative updates: Alternative health funding preserved in the federal budget. Initial fear that support would be cut; instead, it was kept in the proposed budget. The Dietary Supplement Access Act proposal: Would classify dietary supplements as a qualified medical expense in the IRS code. Allow individuals to claim up to $500/year (and $250 for married filing separately) for supplements. Could apply to common products like multivitamins, vitamin D, etc. if/when finalized. The post Radio Show / Podcast – June 14, 2026 first appeared on Vital Health Radio.
Could you have metabolic dysfunction even at a normal weight?This episode challenges everything we've been taught about weight and health. Dr. Cooper reveals that up to 25% of normal-weight people have metabolic syndrome, yet they're rarely screened because doctors assume they're healthy based on appearance alone.KEY TAKEAWAYSWeight and metabolic health are not the same thing - you can be metabolically unhealthy at any sizeNormal weight people with metabolic dysfunction are often overlooked and undertreated by healthcare providersKey screening tests include fasting glucose, insulin, HbA1c, triglycerides, HDL cholesterol, blood pressure, and inflammatory markers like HSCRPMetabolic dysfunction can start in your 20s and take decades to develop into serious diseaseBoth normal weight and higher weight patients face bias - normal weight people aren't screened enough, while higher weight people have everything blamed on their weightEarly screening and treatment can prevent catastrophic health outcomes later in lifeThe liver plays a crucial role in metabolism and can become insulin resistant regardless of body weightNOTABLE QUOTE"You cannot tell anything about someone's health from their outside, what they look like or what, even what they're doing necessarily, but definitely not their body size. So you can be healthy or unhealthy at any size body, and I think that's what's overlooked quite a bit." — Dr. Emily CooperLinks & ResourcesPodcast Home: fatsciencepodcast.comCooper Center for Metabolism: coopermetabolic.comResources from Dr. Cooper: coopermetabolic.com/resourcesJoin Our Community: patreon.com/cw/FatSciencePodcastSubmit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comAppendix: Key ReferencesPrimary literature supporting this episode• Wang et al. Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes. Journal of Clinical Endocrinology & Metabolism, 2023.• Review: Beyond BMI — Rethinking Obesity Metrics and Cardiovascular Risk in the Era of Precision Medicine. Journal of Clinical Medicine, December 2025.• Korean meta-analyses on metabolic dysfunction phenotypes and cardiometabolic risk, Cardiovascular and Metabolic Sciences Journal review, 2024.• Frontiers in Nutrition, January 2026. Associations of metabolic heterogeneity with the progression of cardiometabolic multimorbidity.• International Journal of Obesity, September 2025. Cardiovascular risk factors associated with metabolic health phenotypes.Mechanism references• MASLD — metabolic dysfunction-associated steatotic liver disease — nomenclature and clinical framework. AASLD/EASL consensus, 2023.• Insulin signaling, adipose tissue dysfunction, and ectopic fat deposition — reviews on the upstream-downstream relationship.• Epicardial adipose tissue and cardiovascular dysfunction — Frontiers in Cardiovascular Medicine, January 2026.Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Matt: Hi Dr Cabral, I'm constantly trying to improve my sleep but can rarely ever get more than 6 to 6 1/2 hours consistently. If I go to bed earlier, I wake up earlier ready to go. Right now I'm taking 2g of taurine, balanced zinc, 500mg magnesium, 100mg theanine, 50mg Apagenin and 3g of glycine. I have no problem falling asleep but consistently wake up around 3-4am. I recently added some Inositol to help get back to sleep but I can't really remember the last time I went to sleep and woke up the next morning by my alarm clock. Just to note, I'm 45 with 3 kids that also like to pop in our room in the middle of the night. Any tips to help get that 7-8 hours I need? Tricia: Hello Dr C! I'm 57 and I tested my estrogen and progesterone. I'm of course estrogen dominant. I started taking your progesterone support and gosh it is amazing! My sleep has gotten even better! My question is do you think I should take the estrogen supplement too to help balance the two? Are these usually lifetime supplements for post menopausal women? Thanks Kevin: Just received my annual labs back for annual physical and total Cholesterol is 299, Triglycerides 70, HDL 105, LDL 180, ratio 3.8, and LDL Direct at 182. I have Hashimoto disease, candida for past couple of years and mycotoxins from mold exposure. I cant afford to move out of house so I'm still exposed. I had a functional doctor but can no longer afford the out of pocket expenses. I was on cholestramine powder along with binders but stopped doing them last year because not helping. I'm really worried about having stroke or heart attack. I don't know where to start anymore and been told without moving nothings going to work. What do you recommend I do.? I plan on purchasing Proteolytic Enzymes with Nattokinase to hopefully reduce plaque. What tests do you think would be best for me? Sienna: Hi Dr. Cabral - hoping you can help! In a country where FM labs aren't an option + entering into mid-40's, surrounded by Perimenopause "fear". I have done your hormone HRA + apart from feeling like I get TRIGGERED a lot easier, I don't have more of the common symptoms (ie night sweats). My cycle the last 2 months was slightly longer but don't want to over think it. I am wondering if there are bloods that can help outline where we are in terms of our hormones (I know saliva is preferable)... I really want to support my hormones, and know you say we can do this naturally well into later life ie 60's! I know estrogen declines + ED is common - would appreciate markers to look at, ranges + if your wife couldn't test what you'd recommend for her :) Thank you for ALL you do! Sienna Rianna: Hi Dr. Cabral! Sleep it's an area I am REALLY focused on supporting - we know when we are tired everything is harder ;-) & I am all about energy as I move towards my mid-40's.. I track my sleep on Garmin + know you mention Deep Sleep (90 mins) + Rem Sleep (2+ hours) as ideals, but I am no where near there consistently. The only time I get quite close is during my detox. My HRV has improved considerably (almost doubled) since Jan(through substantially reducing alcohol intake + focusing on sleep hygiene). I average on 7 - 7.5 hours sleep, mostly right through or brief wake, + mostly feel great/rested. My REM sleep this morning was 0 minutes (??) - is that reall even possible? 80 mins deep, 6.5 hrs"light" - how much attention would you give it if you feel recharged? Tips? Thx for all you do! Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3782 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
This episode is brought to you by The Primal Skincare. Vascular surgeon Dr. Lily Johnston breaks down the definitive science of heart attack prevention and evaluates how modern diet and lifestyle choices directly accelerate or mitigate your cardiovascular risk. We explore the complex biological mechanisms underlying plaque formation and arterial rupture, moving beyond outdated dogmas to examine the real drivers of vascular disease: chronic inflammation, metabolic dysfunction, and the direct effects of insulin and glucose on your endothelial lining. Whether you are navigating the nuances of cholesterol management or looking for the most accurate diagnostic testing, this episode provides an authoritative, evidence-based roadmap to optimize your heart health and protect your arteries.In This Episode, We Reveal:The Pathophysiology of Plaque: How arterial plaque forms, why it ruptures, and the crucial clinical distinction between volatile soft plaque and stable calcified plaque.The Metabolic Drivers: The profound impact of chronic glucose and insulin elevation on arterial degradation.Advanced Diagnostics: Why standard lipid panels fail to show the whole picture, and how advanced imaging tools can detect early-stage disease.The Cholesterol Matrix: A scientific contextualization of LDL, the complexities of HDL, and whether elevated markers are a true risk factor on low-carbohydrate diets.Dietary Realities: A medical critique of common foods, the cardiovascular impact of processed ingredients, and the evidence supporting the Mediterranean diet.Scientific Resources & Dr. Johnston's Work:Dr. Lily Johnston (YouTube): https://www.youtube.com/@lilyjohnstonmdCleerly Health: https://cleerlyhealth.com/CardioRisk Ultrasound Testing: https://cardiorisk.com/HeartFlow CT Analysis: https://www.heartflow.com/
In this episode the guys break down the four biggest fitness traps of 2026 — over-reliance on wearables and tech, the GLP-1 shortcut and muscle loss crisis, chasing longevity fads over basics, and aesthetics over everything. They also get into the alien.gov website reveal (spoiler: not what anyone expected), the black market GLP-1 side hustle spreading through social circles, a new study showing resistance training beats cardio for fat loss head to head, and Doug's 30-day Dose liver enzyme experiment update. Then they coach live callers submitted through mplivecaller.com — Aidan from Kansas on lingering strength and nerve issues after mono, Jamie from Oklahoma on rebuilding her relationship with food and training after anorexia and overtraining, and Caleb from Pennsylvania who shares an inspiring 18-month reverse diet success story before getting help with chronic forearm pain. MAPS Summer Sale — https://mapsfitnessproducts.com Code: SUMMER40 — 40% off everything (programs, bundles, mods & guides) — June 1–14 only SPONSORS Vuori — https://vuoriclothing.com/mindpump 20% off first order — no code needed, automatically applied Dose (liver & cholesterol support) — https://dosedaily.co/MINDPUMP Code: MINDPUMP — 25% off first month subscription. Clinically backed, all-natural liquid supplement. Supports liver enzymes, LDL, HDL and skin health. Fatty15 (C15 essential fatty acid) — https://fatty15.com/MINDPUMP Code: MINDPUMP — additional 15% off the 90-day Starter Kit subscription. C15 has been shown to have 3x more cellular benefits than omega-3. LINKS Submit a live caller question: https://mplivecaller.com Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 2:12 - Fitness trap #1: Over-reliance on wearables and tech — when data becomes a stressor 8:21 - Fitness trap #2: GLP-1 and the muscle loss crisis — what nobody is telling you 16:36 - Fitness trap #3: Chasing longevity fads while ignoring the basics 20:56 - Fitness trap #4: Aesthetics over everything — why chasing the look kills the look 33:23 - Vuori — the random guy at the park who wouldn't stop complimenting Sal's joggers 44:57 - Resistance training vs. cardio for fat loss — new head to head study 47:57 - Dose liver supplement — skin benefits and Doug's 30-day cholesterol experiment 55:43 - Alien.gov — the government website reveal nobody saw coming 59:33 - Caller: Aidan (Kansas) — college swimmer, post-mono nerve issues, lost 100lbs on bench 1:13:13 - Caller: Jamie (Oklahoma) — anorexia history, overtraining, inner thigh pain, gets a coach 1:27:24 - Caller: Caleb (Pennsylvania) — 18-month reverse diet success story, now dealing with forearm pain
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginning with the fundamentals of cholesterol transport before exploring why the brain's cholesterol system operates almost entirely independently from the rest of the body. Tom examines the roles of apoB, apoA-I, and especially apoE in cholesterol homeostasis, discusses how APOE genotype influences Alzheimer's disease risk, and unpacks the complex links between cholesterol metabolism, amyloid, and tau pathology. He also reviews what is currently known—and still uncertain—about the effects of statins, ezetimibe, omega-3 fatty acids, and emerging CETP inhibitors on brain health and neurodegenerative disease risk. Although highly technical, this conversation provides an essential framework for understanding the nuanced relationship between lipid-lowering therapies, cardiovascular disease prevention, and neurodegenerative diseases in an area often clouded by misinformation. We discuss: The fundamentals of cholesterol transport in the body, and how peripheral cholesterol metabolism differs from cholesterol handling in the brain [2:45]; How cholesterol is transported through plasma and stored within cells, and why lowering LDL cholesterol does not deplete the body or brain of cholesterol [11:45]; How apoB particles drive atherosclerosis, why lowering lipids matters, and the factors that influence individual cardiovascular risk [20:00]; How the brain produces and transports its own cholesterol using apoE lipoproteins independently of circulating cholesterol and apoB-containing lipoproteins [29:00]; How apoB structure influences LDL receptor binding and LDL clearance [39:00]; How neurons acquire cholesterol from apoE-containing lipoproteins and why desmosterol serves as a unique marker of cholesterol synthesis in the brain [41:45]; The difference between the APOE gene and the apoE protein, the major APOE genotypes found in humans, and how APOE4 influences Alzheimer's disease risk [48:45]; HDL function beyond cholesterol: immune function, protein cargo, and communication with the brain [53:30]; How APOE4-associated defects in brain cholesterol transport may promote Alzheimer's disease: amyloid production, neuronal cholesterol homeostasis, and cholesterol clearance [58:00]; Statins and brain health: reviewing the evidence of the potential impact of statins on cognition and Alzheimer's disease risk [1:09:00]; Desmosterol and 24S-hydroxycholesterol as biomarkers of brain cholesterol metabolism and statin effects [1:17:15]; Possible cognitive benefits of ezetimibe beyond lowering apoB [1:19:30]; EPA, DHA, and the evidence for omega-3 fatty acids in brain health [1:23:15]; Obicetrapib: an emerging CETP inhibitor with potential implications for both cardiovascular and brain health [1:31:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
In this fascinating episode of the Optimal Protein Podcast, Vanessa Spina is joined by Dr. Fernando Naclerio, Professor in Strength Training and Sports Nutrition at the University of Greenwich and Centre Lead for the Centre for Exercise Activity and Rehabilitation. Vanessa and Dr. Naclerio dive into a brand new meta-analysis comparing higher-carb and lower-carb diets when calories and protein are matched. While both approaches improved body composition, the low-carb diets produced greater reductions in fat mass, fasting glucose, fasting insulin, and triglycerides, along with increases in HDL. This conversation explores why not all weight loss is fat loss — and why consuming too many carbohydrates during a calorie deficit may, in certain conditions, shift the body toward burning more lean mass instead of body fat. They also discuss how to structure protein, carbohydrates, and fats for better body composition, why carbohydrate tolerance depends on activity level, the importance of resistance training, keto adaptation, meal timing, fasting, protein distribution, and why protecting muscle should be the priority during fat loss. The PSMF Library is officially live
In this episode of Everyday Epigenetics: Raw. Real. Relatable., Susan Robbins is joined by renowned expert lipidologist Dr. Tom Dayspring for Part 1 of a special two-part series on genetically driven lipid disorders. Together, they explore phytosterolemia (formerly known as sitosterolemia), a little-known but potentially serious genetic condition that affects how the body absorbs and processes plant sterols. While often overlooked in conventional healthcare, this disorder can contribute to elevated cholesterol markers, cardiovascular risk, xanthomas, kidney issues, and other health concerns when left undetected.Dr. Dayspring breaks down the complex science of cholesterol absorption, plant sterols, and the ABCG5 and ABCG8 genes in a way that is easy to understand. Susan shares what she has observed through years of genetic testing and coaching, including how frequently she is seeing these gene variants appear in practice and why many people are being missed by standard testing. This conversation highlights the importance of personalized medicine, advanced lipid testing, and understanding the unique ways genetics can influence long-term health outcomes.In this episode:What phytosterolemia is and why it is often missedThe difference between cholesterol and plant sterolsHow the ABCG5 and ABCG8 genes regulate sterol absorptionWhy some people absorb significantly more cholesterol than othersThe connection between plant sterol hyper-absorption and cardiovascular disease riskWhy standard cholesterol testing may miss important cluesThe role of sitosterol and campesterol testingHow phytosterols can impact cell membranes, kidneys, joints, blood cells, and other tissuesThe difference between heterozygous and homozygous loss-of-function gene variantsWhy many patients are told their cholesterol is "fine" when deeper issues may existThe importance of ApoB, non-HDL cholesterol, and advanced lipid testingWhy some cholesterol-lowering therapies work better than others depending on geneticsHow lifestyle, nutrition, and personalized interventions can support lipid healthWhen to consider working with a lipid specialistIf you have a family history of heart disease, unexplained cholesterol elevations, or have been told your numbers are "normal" despite ongoing concerns, or if use of statins hasn't helped yu, this episode offers valuable insight into a genetic factor that is rarely discussed but can have a significant impact on long-term health.Learn more about Dr. Tom Dayspring on the website shownotes!https://healthyawakening.co/2026/06/08/episode127/RESOURCES:Connect with Dr. Tom DayspringX: https://x.com/drlipidhttps://healthyawakening.co/2026/06/08/episode127/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast
This podcast is listener-supported. To receive new posts and support my work, consider becoming a free or paid subscriber.When we think about staying healthy, we naturally focus on daily habits like a balanced diet, exercise, and stress management. But there is a critical, often overlooked window into our body's internal workings that tells us exactly how those efforts are paying off: regular blood work.In this episode, I dive deep into the world of biomarkers and explore why tracking these numbers is the most powerful tool we have for detecting potential health issues before they ever show physical symptoms.I break down what is actually being measured in standard lipid and metabolic panels, debunk common misconceptions about “optimal” cholesterol levels, and look at the real-life numbers from my own recent blood work for reference. Whether you are curious about how a plant-based diet impacts your numbers or want to know which hidden tests you need to request at your next checkup, this episode serves as your comprehensive guide to owning your health.CAMBODIA 2027: Join me on an unforgettable journey from the breathtaking temples of Angkor to the vibrant streets of Phnom Penh. Join us for Culture, Cuisine & Conservation. Enter JOYFULVEGAN when booking to redeem the special offer of a one-on-one or private cooking class with me.In this episode we cover:* Why serious cardiovascular issues can develop silently without physical symptoms, and how early screening acts as a lifesaver* A simple “garbage truck” analogy to easily understand the differing roles of LDL and HDL cholesterol in your bloodstream* What clinical data reveals about the ideal total cholesterol threshold for eliminating heart attack risk* The chemical difference between animal-based saturated fats and plant-based options like coconut oil* The biological differences between Type 1 and Type 2 diabetes, and how to prevent insulin resistance naturally* How to meet your iron requirements effortlessly on a plant-based diet without unnecessary and dangerous supplementation* Key vitamins, minerals, and inflammation markers that are omitted from standard panels but are vital to request* A look at my own recent blood numbers and a personal story regarding hair thinning, perimenopause, zinc, and B12.
Equip Foods grass-fed beef protein (20% off with Ben's link): https://bit.ly/3RKCzhW — use code BENAZADI Pre-order Keto Flex Revised and get free bonuses: https://bit.ly/4wKG1sM Ben Azadi spent 90 straight days eating nothing but beef, eggs, butter, salt, and organ meat. No vegetables, no fruit, no fiber, no carbs. Then he tested everything. His cholesterol numbers would have sent most doctors into a panic. His total cholesterol hit 434. His LDL hit 350. But when one of the world's top heart surgeons reviewed the full panel, the verdict was clear: his cardiovascular risk had actually improved. Then the gut results came in. After 90 days of zero plants and zero fiber, his gut microbiome diversity went up. Not down. Up. In this episode, Ben walks through everything: the adaptation period, the body composition changes, the full blood work breakdown with board-certified cardiothoracic surgeon Dr. Philip Ovadia, the gut microbiome reveal with Dr. Will DiPaolo and Dr. Daniel Pompa, and what the science actually says about cholesterol, red meat, and the human body. If you've ever been told that saturated fat will kill you, that LDL is the enemy, or that you need fiber to have a healthy gut, this episode will make you question all of it. Key takeaways: Lost 16 pounds and 6% body fat in 60 days Heart rate variability, sleep quality, and glucose all improved Triglyceride-to-HDL ratio hit 1.0, a marker of near-zero insulin resistance Gut diversity, keystone bacteria, and core bacteria all increased on zero plants LDL on its own is one of the worst predictors of actual cardiovascular risk Find All The Ben Azadi Show Sponsorship Deals https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices
Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.
Are your daily habits negatively impacting your hormones and your overall health? And when it comes to hormones, are you focusing on only your sex hormones? It turns out other hormones are running the show! This episode breaks down common hormone dealbreakers and practical steps you can take to avoid them and reclaim your health.On this episode of Salad with a Side of Fries, host Jenn Trepeck is joined by Robin Nielsen, board-certified integrative nutritionist and founder of Natural Hormone Solution, to unpack the hidden hormone dealbreakers quietly sabotaging your health. From the real role of cortisol rhythm to the truth about cholesterol and sex hormones, xenoestrogens in your face cream, and why your to-do list is wrecking your endocrine system, this conversation is a masterclass in natural hormone balance for women at every stage of life.What You Will Learn in This Episode:✅ Why cortisol and insulin are your two most important hormones and how their dysregulation drives symptoms that are often misread as perimenopause or aging.✅ How environmental xenoestrogens found in face creams, shampoos, and household cleaners silently disrupt your estrogen balance and what to do about it.✅ The critical connection between eating for hormone balance, meal timing, and why skipping breakfast and over-exercising are two of the most damaging habits for women's hormonal health.✅ How cholesterol actually serves as the building block for all your steroid hormones, and why lowering it too aggressively may be making your symptoms worse.The Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS:00:00 Jenn introduces Robin Nielsen, founder of Natural Hormone Solution and integrative nutritionist04:57 Robin shares her personal story: decades of weight gain, cystic acne, and digestive health issues09:18 Why common symptoms are not normal: hormone imbalance signs you may be ignoring11:27 Your sex hormones aren't the only ones linked to your overall health and wellness15:41 Cortisol rhythm explained: how your brain responds to daily stress and excess cortisol21:14 Hormone dealbreaker one: how negative thoughts and low serotonin levels disrupt cortisol23:24 Hormone dealbreaker two: xenoestrogens, environmental toxins, and harmful body care products27:47 The importance of eating breakfast and the benefits of walking33:19 Discussion of cholesterol levels and balancing HDL and LDL numbers38:12 The surprising hormone dealbreaker hiding in plain sight: your to-do list and nervous system healthKEY TAKEAWAYS:
Iron Radio: Do Supplements Beat Food for Vitamin Status? Wearable Food-Tracking Glasses + HDL, Exercise & Depression On Iron Radio, hosts Dr. Lonnie Lowery, Dr. Mike T. Nelson, and Coach Phil Stevens discuss Nelson's Flex Diet Certification and how supplementation topics are integrated due to time constraints, plus his creatine research PDF. They review a new NHANES-based paper (Sternberg et al., May 2026) suggesting supplement use explains more variability in vitamin biomarkers (R² ~3–21%) than reported dietary intake (~0.8–8.8%), while noting limitations like recall bias, low explained variance, and imperfect biomarkers. They then examine a 2021 AIM2 wearable device that detects eating episodes and captures food images with ~83% accuracy, debating research benefits versus privacy and data-broker concerns. Finally, they critique a 2026 cross-sectional study linking physical activity, HDL cholesterol, and lower depression odds, arguing the effect is associative and likely non-causal, and expand into broader concerns about interpreting lipids in athletic populations and medical risk models. 00:00 Show Intro and Hosts 01:05 Flex Diet Cert and Supplements 03:23 Brevity in Science Talks 05:34 Talk Tactics and Backup Slides 08:22 Supplements vs Food Biomarkers 14:04 Vitamin D and Biomarker Limits 15:21 Iron Radio Feed Update 16:32 Newsletter and Book Plug 18:21 Wearable Food Tracking Glasses 21:00 Privacy and Data Broker Fears 23:21 VR Ads and Escape 23:53 Food Illusions and Conditioning 24:27 Research Uses vs Privacy 26:20 Testing Dietary Recall Accuracy 27:39 HDL Exercise and Depression Study 30:29 Is HDL Really Causal 33:21 Selling Results in Titles 35:02 HDL Drugs and High HDL Debate 37:08 Statins Risk Models and Exercise 40:15 Athlete Labs and Wrap Up Donate to the show via PayPal HERE.You can also join Dr Mike's Insider Newsletter for more info on how to add muscle, improve your performance and body comp - all without destroying your health, go to www.ironradiodrmike.com Thank you!Phil, Jerrell, Mike T, and Lonnie
Eat this every single day to help prevent clogged arteries and support heart health. Focus on heart attack prevention by addressing the real cause of artery plaque buildup in the first place.
In this episode I look at blood tests that tell us about what's going on with our biological processes in terms of our long term metabolic health and the blood markers are relevant.Hba1c control: https://pmc.ncbi.nlm.nih.gov/articles/PMC4933534/Fasting insulin: https://pubmed.ncbi.nlm.nih.gov/11118012/Vitamin D: https://pmc.ncbi.nlm.nih.gov/articles/PMC10002864/AST/ALT: https://pmc.ncbi.nlm.nih.gov/articles/PMC10346959/Triglycerides and HDL ratio: https://pmc.ncbi.nlm.nih.gov/articles/PMC11493158/ApoB: https://pmc.ncbi.nlm.nih.gov/articles/PMC11219008/HDL cholesterol: https://pmc.ncbi.nlm.nih.gov/articles/PMC6077683/Hs-CRP: https://pmc.ncbi.nlm.nih.gov/articles/PMC9650935/Homocysteine: https://pmc.ncbi.nlm.nih.gov/articles/PMC12564181/Uric Acid: https://pmc.ncbi.nlm.nih.gov/articles/PMC8624633/Do Health: https://dohealth.co/what-we-measure#wwm-step-1Save your life in slow motion and those of others by subscribing now and sharing. Thank you for listening and for your support. It means a lot to me. Hosted on Acast. See acast.com/privacy for more information.
Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) testedWhat a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person datasetWhy the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat aloneThe simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular riskBy the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.Thank you to our sponsors:OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYONBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Kevin Maki at:Midwest Biomedical Research: https://www.mbclinicalresearch.com/ LinkedIn: / kevin-c-maki-phd-497ba34 Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction00:31 - Dr. Kevin Maki and the National Lipid Association01:04 - New dietary guidelines and the LDL confusion02:04 - What raises and lowers LDL cholesterol03:51 - Cholesterol levels from birth through puberty05:11 - The lipid panel kids should get before age 1106:42 - Lp(a): the test only 2% of people get08:18 - ApoB and the three risky particle types11:35 - Do we have evidence for "lower is better"?14:09 - The FLASH-GLICK risk factor framework17:10 - The 10% saturated fat guideline explained19:36 - Many dietary patterns can be healthy24:50 - Beef vs. chicken: identical LDL results27:10 - The balance of fatty acids that matters29:24 - Olive oil vs. corn oil feeding study31:00 - Lower for longer: 40-year risk reduction34:15 - Genetic cholesterol disorders and risk40:33 - The omega-3 index and why it matters49:10 - Are seed oils really driving inflammation?53:11 - How seed oils are processed and refined1:07:48 - Inherited beliefs and outdated nutrition science1:08:54 - Butter vs. cheese and high-fat dairy surprises1:14:48 - Exercise effects on HDL and triglycerides1:21:20 - The ABCs of reducing cardiovascular riskIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
Health/lifestyle consultant, 14-year carnivore and drummer Phil Escott got chronically ill as a vegetarian, and his body revolted with psoriatic arthritis and other autoimmune conditions in 2010, leaving him unable to move without severe pain, let alone drum or exercise, and he had to throw out all his existing “expertise” and start from scratch. Phil's eventual combination of a carnivore diet with EMF and artificial light avoidance, cold thermogenesis and a range of other health enhancing practices reversed the “incurable” diseases that he suffered from. His book “Arthritis, The Best Thing That Ever Happened to Me” gained a foreword by Dr. Jack Kruse and has become an Amazon Kindle bestseller and is now available in print. Phil talks from personal experience about contemporary lifestyle and diet choices, disconnects from our ancestral heritage, emotional balancing and the simple but often misunderstood nature of spiritual awakening. He now consults with clients worldwide helping them to reverse their metabolic and autoimmune issues and runs The Big Fat Challenge with Ben Hunt as his main project. His latest book, the "Red Pill Revolution" is awesome. Melissa Lim is a Canadian American Pharmacist and volleyball player/enthusiast. She was inspired by a previous episode with "meat militia" member Phil Escott and leader Dr Bart Kay. Her journey on completely overhauling her diet has had life changing results, from getting rid of Acne she has had since age 9, to an energy level and clarity that is shooting through the roof. The chronological path of paying it forward continues. 02:39 - Melissa's journey to carnivorism, the ailments the journey, the right path, Phils tells his journey of the same that led to his first book 26:23 - Why carnivorism is now a growing culture, not a diet but a species appropriate way of life, how to maintain sources of vitamin C, discussing the notion that athletes "need" carbohydrates or not, the glycemic chart and how to use it 39:33 - Having the difficult discussion with loved ones on the benefits or health changes, perhaps best to lead by example and show the results, first-hand, understanding that the opposition is not monolithic, the division between the stubborn, the willfully ignorant, and how the sales pitch can help people or turn them off 50:01 - Getting rid of foods that are addictive and diminishing your quality of life, who needs this more than most and how to help 1:12:33 - The silly notion of this being a "grift" (the censorship, the loss of reputation, the amount of work being done for free), the perfect "stool" lol, the attack by General Mills on our breakfast index, and why none of it was scientific 1:23:42 - Meds that help and meds that kick the can down the road, the leaky gut, inflammation, HDL and LDL and how people misinterpret it, what you are being told to do, vs the one who has to live with the results (you), plus, what feeds the gut Biome? 1:37:39 - HDL and LDL and how people misinterpret it, seed oils, and throwing away the meat for the sins of the bun, plus, new events, retreats, seminars and getaways
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Jacquie: My 65-year-old mom was diagnosed with osteoporosis via DEXA (spine -2, hip -3). She's had a hip replacement & later suffered a fall that fractured her femur near the implant. Listened to your other podcasts & I wonder are there cases where the body can't rebuild bone without conventional intervention? Is there research on this? Her doctor recommended injections, saying vitamins alone won't restore bone to the needed level—how valid is that? She does quarterly detoxes & takes DNS, omega3s, vitamin D/K2 drops, & CalMag. She plans to add Daily Bone Support, reduce inflammatory foods & alcohol & increase weight-bearing exercise as able. Testing suggests she follow a limited CBO protocol. Not giving medical advice, what would you do/look into if this was your family member? Thank you! Lynne: I don't see eggs on the food list. Is it ok to eat eggs after the detox? If so, how often. I can get fresh eggs from a local farm and I love them. Drew: Dr Cabral, I heard on another podcast (Rhonda Patrick) there was a research study that showed high speed blenders like Blentech and Vitamix can expose you to microplastic due to ingredients hitting the side of the plastic container. this is increased if using frozen ingredients such as blueberries or ice. i have been making a smoothie for breakfast for almost ten years. i would love to get your take on this. if this is true? should my highspeed blender be replaced (Blentech does not have a Stainless steel or glass container option). should someone who may have been exposed take any extra steps to detox? thank you so much Lisa: I seen your post on berberine and was wondering when is the best time of day to take it? Should I take it with every meal or just once a day? Should I take it before eating or after? You said it can help with fat burning even while sleeping so should I take before bed? Should I avoid taking it with my pre workout meal? Thank you in advance Lisa Jill: Hello, thank you for your informative and educational emails. Looking for the best applications of using Proteolytic Enzymes vs. Niacin for lowering cholesterol and triglycerides and increasing HDL if calcium score is zero. What would the recommended doses be of each? Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3754 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Planck, Einstein, Bohr, Heisenberg, Schrödinger, Dirac… Son algunos de los científicos más brillantes del siglo XX que alumbraron la mecánica cuántica. En la actualidad, es la base fundamental de nuestra tecnología y sociedad de la información, aunque fue muy difícil de aceptar al principio porque desafiaba la intuición clásica y el determinismo científico. El desarrollo de la bomba atómica fue la prueba experimental más cruda y aterradora de aquellas teorías. Del desarrollo de esta rama de la física, con sus protagonistas y sus complicados conceptos hemos hablado con Sonia Fernández Vidal, autora de “La sombra de los dos soles” (Destino) y comisaria de la exposición “Revolución Cuántica” en el Espacio Fundación Telefónica. Pilar Quijada nos ha informado de una nueva estrategia contra la celiaquía desarrollada por científicos del CSIC y la universidad de Barcelona. Se trata de una enzima obtenida a partir de una molécula presente en una planta carnívora, que es capaz de degradar el gluten en condiciones muy ácidas, como las del estómago. Con testimonios de Xavier Gómis-Rüth (IBMB/CSIC), Marina Girbal-González (UB) y Francisco Pérez Cano (INSA/UB). Álvaro Martínez del Pozo nos ha hablado de las lipoproteínas, moléculas que se encargan de transportar en sangre grasas insolubles como el colesterol, y entre las que se encuentran las famosas LDL y HDL. En nuestro recorrido por el grupo de los halógenos pesados en la Tabla Periódica, Bernardo Herradón nos ha contado como se obtuvieron en laboratorio los elementos químicos astato y teneso y quienes fueron los descubridores del bromo y el iodo y los métodos empleados. Hemos informado del Premio Prince Asturias a los pioneros de la secuenciación rápida de ADN, los químicos británicos David Klenerman y Shankar Balasubramanian y el biofísico francés Pascal Mayer; y del Premio CSIC-Fundación BBVA de Comunicación Científica en la categoría de investigadores a Carlos Briones, del Centro de Astrobiología y colaborador de nuestro programa. También ha sido premiado Josep Corbella, redactor de La Vanguardia, en la categoría de periodistas. Escuchar audio
This week on The AGEIST Podcast, Dr. Florence Comite, clinician-scientist, and author of Invincible: Defy Your Genetic Destiny to Live Better, Longer, explains why “normal” lab results can miss the early signals that shape long-term health. Learn how sugar, insulin, A1C, cholesterol patterns, HDL, and free testosterone can reveal metabolic changes before a conventional diagnosis appears. She makes the case for tools like CGMs, deeper family history, better sleep, strength training, and hormone awareness as practical ways to understand what is happening beneath the surface. The episode gives the audience a clear framework for asking better questions, acting earlier, and taking more precise ownership of the next decades of their health.Are you competing in the Super Age Games? Join us at the first longevity fitness competition on Nov 7, 2026. Visit games.superage.com to learn more.Special Thanks to Our SponsorsTimeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners can now get 20% off their first Timeline purchase by using the code “AGEIST” at checkout at TimelineNutrition.com/ageist.LMNT Electrolytes: Our #1 electrolyte brand for optimal hydration, and their new 12oz sparkling cans are officially for sale online! Get a free Sample Pack of LMNT's most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.Key Moments“I want everyone to own their future health destiny.”“The first phrase that's completely wrong is you're in the normal range and everybody relaxes.”“Aging is not a disease, it's a gift.”Connect with Dr. ComiteWebsiteComiteMDInvincible: Defy Your Genetic Destiny to Live Better, LongerConnect with AGEISTNewsletterInstagramWebsiteLinkedInClick Here for the full interview transcript.Say hi to the AGEIST team!
A gene mutation that reduces ketone production in the fasted state is associated with sudden infant death in modern populations. But in the ancestral context where it evolved alongside an omega-3-rich diet, it may have been part of what kept infants alive.Dr. Gideon Mailer and Nicola Hale join The Metabolic Link to present their hypothesis that the CPT1A L479 Arctic variant is not anti-ketogenic but pro-metabolic flexibility, conserving glucose by upregulating ketosis at the fed-state threshold. Their work explains why SIDS rates are dramatically elevated in modern Inuit communities no longer eating the ancestral Inuit diet, and how omega-3 fatty acids counteract the downregulation the mutation produces.The clinical picture extends beyond infancy. Modern carriers of the variant show lower triglycerides, lower VLDL, slightly higher HDL, and a "healthy obesity" phenotype with favorable fat distribution. But the health advantages seen in traditional Inuit populations disappear with Western diet adoption, as cardiovascular disease and diabetes rates rise to match the general population.Questions Answered in This Episode:How is the mutation associated with SIDS, and why is there a detrimental effect in modern populations?How prevalent is the CPT1A Arctic variant in the U.S. population, and does partial Inuit ancestry carry metabolic consequences?How do omega-3 fatty acids physically upregulate CPT1A activity and concentration within cell membranes?What metabolic markers distinguish carriers of the L479 variant from non-carriers?What happens to cardiovascular disease rates in Inuit populations that adopt Western diets?What should people take away from the Arctic variant story for their own metabolic health?A sobering case study in what happens when ancestral genetic adaptations collide with modern dietary environments, and what can be recovered when they are realigned.Special thanks to the sponsors of this episode:✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here✅ ZocDoc - Find and instantly book a top-rated doctor hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In Episode 196 of the Fit Mother Project Podcast, Dr. Anthony Balduzzi sits down with board-certified cardiac surgeon Dr. Philip Ovadia for a deep, myth-busting conversation on the real root causes of heart disease.Dr. Ovadia has operated on thousands of patients, transformed his own health by losing nearly 100 pounds, and now dedicates his work to keeping people off the operating table entirely.Together, they challenge decades of conventional medical thinking around cholesterol, statins, and dietary fat, and replace it with a clearer, more empowering framework built around insulin resistance and inflammation.Dr. Ovadia shares the five key steps to reversing insulin resistance, the five basic metabolic markers everyone should know, what advanced lipid testing can reveal that a standard panel misses, and how to build a diet centered on whole, real food. He also explains where statins genuinely help, where they fall short, and why the standard American approach to heart disease prevention simply has not worked. If you want to understand what is actually driving heart disease — and what you can do about it starting today — this conversation delivers both the science and the practical tools to take action.Rate & Review - If this episode encouraged you, please rate and review the Fit Mother Project Podcast. Your support helps more women over 40 find empowering, practical guidance for building lifelong health and strength.Join the Fit Mother Community - If you want support putting these ideas into practice, come join the Fit Mother community. We are here to help you build strength, confidence, energy, and sustainable health in every season of life. Fit Mother ProjectKey Takeaways:The real root causes of heart disease: inflammation and insulin resistanceWhy 50 years of focusing on cholesterol has not reduced heart diseaseHow plaque builds up and what actually triggers itDietary cholesterol vs. blood cholesterol (what the difference means for you)Lipoproteins explained: HDL, LDL, VLDL and why not all are harmfulWhy LDL cholesterol is only half the storyLarge fluffy vs. small dense LDL particles (why particle quality matters more than quantity)88–93% of American adults have some degree of insulin resistanceThe five-step plan to reverse insulin resistanceWhole real food as the foundation of a heart-healthy dietHow carbohydrate reduction supports metabolic healthCarbohydrate targets: under 20g for diabetics, up to 100g for insulin-sensitive individualsWhy keto and carnivore diets can be heart-healthy approachesThe role of muscle mass in protecting against insulin resistanceSleep as an underrated pillar of metabolic healthWhole fruit, fiber, and polyphenols (how to include them wisely)The five basic metabolic health markers you can measure yourselfWaist circumference targets: under 40 inches for men, under 35 inches for womenBlood pressure, fasting glucose, triglycerides, and HDL targets explainedHow to know if you are insulin resistant before your doctor tells youAdvanced lipid panels and NMR testing (what to ask for and why)When statins help — and when they offer no benefit at allPCSK9 inhibitors and the evidence for metabolically healthy patientsRed meat as a nutrient-dense, bioavailable foundation foodDr. Ovadia's personal journey: from morbidly obese cardiac surgeon to optimal health at 52Patient empowerment — why your health should not be outsourced to the healthcare systemOverview of Stay Off My Kitchen Table — Dr. Ovadia's new bookWant To Change Your Life? Check Out Foundations!Foundations is a simple, sustainable, and specific weight loss program designed especially for busy women over 40. With short metabolic training workouts, an easy-to-follow meal plan, and an accountability team there for you every step of the way, Foundations can help you lose weight, regain energy and vitality, and live life to the fullest. Click here to see everything you get when you join Foundations. Subscribe to our YouTube Channel and check out our blog, and follow us on Instagram, TikTok, Facebook, Twitter, LinkedIn, and Threads.*Please know that weight loss results and health changes/improvements vary individually; you may not achieve similar results. Always consult with your doctor before making health decisions. This is not medical advice. This is simply very well-researched information on longevity training, muscle health, and healthy aging.
In this episode of the Fit Father Project Podcast, Dr. Anthony Balduzzi sits down with cardiac surgeon Dr. Philip Ovadia for a deep dive into the nutritional side of heart disease.Dr. Ovadia shares how his own journey from morbid obesity and pre-diabetes to optimal health at 52 completely transformed his approach to medicine, and why he now dedicates his life to keeping people off his operating table.Together, they dismantle decades of conventional wisdom around cholesterol, statins, and dietary fat, and reframe heart disease prevention around its true root causes: inflammation and insulin resistance. Dr. Ovadia explains how atherosclerotic plaque actually forms, why LDL cholesterol is far more nuanced than most doctors acknowledge, and exactly which tests you should be requesting to get a real picture of your metabolic health.He also walks through his top five strategies to reverse insulin resistance, specific carbohydrate targets for different individuals, why red meat may be the most nutrient-dense food a human can eat, and how intermittent fasting fits into a heart-healthy lifestyle.If you want to understand what truly drives heart disease and what you can do about it through food and lifestyle, this episode is essential listening.It is also a great one to share with anyone who has been told their cholesterol is too high or has a family history of heart disease.Rate & Review — If this episode helped you see heart health and nutrition in a new light, please take a minute to rate and review the Fit Father Project Podcast.Your review helps more men discover the show and get the tools they need to live stronger, healthier, and longer.Join the Fit Father Community — Want support from other men working to get stronger, leaner, and healthier after 40?Join the Fit Father Project and surround yourself with people who are committed to living with more strength, energy, and purpose.Key Takeawayswhat actually causes heart diseaseatherosclerotic plaque formation explainedwhy cholesterol alone is not the root causeinflammation and insulin resistance as the true driversdietary cholesterol vs. blood cholesterolHDL, LDL, and VLDL differences explainedlipoproteins and why particle quality matterslarge fluffy vs. small dense LDL particleswhy statins fall short for metabolically healthy peoplePCSK9 inhibitors and the metabolic health nuancefive strategies to reverse insulin resistancewhole real food as the non-negotiable foundationreducing carbohydrates for insulin resistancemuscle building as metabolic protectionsleep and its direct impact on insulin sensitivityberries and whole fruit in the right contextketo and carnivore as legitimate heart-healthy approachescarb targets based on your metabolic statusfive accessible tests to assess insulin resistancewaist circumference guidelines for men and womenblood pressure targets without medicationfasting blood glucose and what the numbers meantriglycerides and HDL as key metabolic markersadvanced lipid panel and NMR testing explainedhow to ask your doctor for better, more actionable labspatient empowerment in a changing medical landscapered meat as the most nutrient-dense foodanimal protein as the dietary foundationnutrient density and bioavailability compared across foodsanti-nutrients in plant foods and who they affectintermittent fasting benefits for heart and metabolic healthDr. Ovadia's simple daily meals and eating approachvegetables, oxalates, and gut health considerationsoverview of Stay Off My Kitchen TableWant To Change Your Life? Check Out Foundations!Foundations is a simple, sustainable, and specific weight loss program designed especially for busy men over 40.With short metabolic training workouts, an easy-to-follow meal plan, and an accountability team there for you every step of the way, Foundations can help you lose weight, regain energy and vitality, and live life to the fullest.Click here to see everything you get when you join Foundations, subscribe to our YouTube Channel, check out our blog, and follow us on Instagram, TikTok, Facebook, Twitter, LinkedIn, and Threads.Please know that weight loss results and health changes/improvements vary individually; you may not achieve similar results. Always consult with your doctor before making health decisions. This is not medical advice — simply very well-researched information on heart disease, cholesterol, insulin resistance, and nutritional strategies for cardiovascular health.
In this episode, I want to talk about something that confuses a lot of people: cholesterol. What it actually is, why your body needs it, and why the LDL number on your lab report doesn't tell the whole story.A new documentary that just came out in April 2026 called The Cholesterol Code got me thinking. It follows Dave Feldman, an engineer who went low-carb, stabilized his blood sugar, felt great, but then saw his LDL go up, and decided to find out why. What he discovered is turning a lot of what we thought we knew about cholesterol and heart disease upside down.Because here's the thing — what if LDL cholesterol isn't really the villain we've been told it is? What if the real problem is chronically elevated insulin?In this episode, I ask the questions:What is cholesterol? And why is it essential?What is the difference between LDL and HDL?How could sugary foods, insulin resistance, and inflammation be risk factors for heart disease?What can you ask your doctor if your cholesterol has changed since cutting sugar?Science is about asking questions, and these ones may challenge 50 years of conventional wisdom about cholesterol, statins, insulin, and heart disease.To get personalized guidance to stop emotional eating and break free from sugar cravings, plus support and accountability... apply here to join the 90-day program, Freedom from Cravings Formula TODAY.Do the Cravings Quiz and take the first step to get rid of your cravings! Struggling with cravings? Download your 5 tips HERE to discover how you can get rid of cravings... even when you feel tired or stressed.To rate and review this podcast:scroll down in your podcast player on your phone and click on the stars. To leave a review, scroll down a little more and click on "Write a Review". Once you've finished, select “Send” or “Save” in the top-right corner. If you've never left a podcast review before, enter a nickname. Your nickname will be displayed on your review.After selecting a nickname, tap OK. Your review may not be immediately visible, but it should be posted soon. Thank you! - NettaDisclaimer: Information provided by Life After Sugar is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. This is general information for educational purposes only. The information provided is not a substitute for medical or professional care. Life After Sugar is not liable or responsible for any advice, information, services or product you obtain through Life After Sugar. You should always seek the adv...
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Bettina: Hello Dr. Cabral, I would like your opinion on an EFSA warning about three supplements: Ashwagandha Intenso, Brain Life, and Curcumin C3 Complex. EFSA reports that ashwagandha may affect the immune system and thyroid function, while curcumin may impact the liver, the GI system, and, during pregnancy, contribute to lower birth weight. EFSA sets the maximum daily intake of curcumin at 210 mg for a 70‑kg adult. Brain Life contains 600 mg, and Curcumin C3 Complex contains 1000 mg, which both exceed this limit. I would appreciate your assessment of the safety of these dosages. Justin: Hello Dr. Stephen Cabral. I just want to start off and say I think you are the most genuine and honest person people can follow right now and I love what you do. I'm about to start the 21 day detox and then plan on moving to the CBO protocol. I'm an ectomorph body type and I work out 3-4 days a week. I know in previous podcasts you have said that my body type needs lots of carbs and protein before and after a heavy lifting workout. I want to continue to try and get some workouts in during this time to keep up my strength and was wondering what you recommend since the meals are separated by 3.5 hours. I know not to workout during the shake fast days and I'm only doing those on the first 2 days since I'm not trying to loose weight. Thanks! Tricia: Hi Dr. Cabral - At different times of our lives, we all go through very stressful life events. As I've gotten older, I really don't handle stress as well. I'm 56 years old. My father is 95-years old, doing great but I see I'm doing more and more and eventually I will be doing more care giving and running between two houses. I'm preparing my cabinet with your best supplements which all have been amazing and work just like you say they do! So, thank you! I do take the Sleep Support supplement once in a while as needed. During stressful events, would you recommend your Adrenal Soothe at dinner along with full spectrum magnesium then the sleep support at bed? I know how important our sleep is and I just can't turn off my mind when life gets to be too much sometimes. Thank you! Sienna: Hi Dr. Cabral - thanks for ALL you do! I ran an omega 3 test, apparently I came back in the top 1% lol AA/EPA ratio: 4.3:1 Omega 6:3 ratio is 4.5:1 (it says the ideal is 3.1 - 3.9) Trans Fat index: 0.18% Omega 3 index: 8.33% I did run my cholesterol markers recently: Total Cholesterol 4.8 optimal HDL 1.4 (low-opt) LDL 3.3 (mild elev) Trig: 0.62 (excellent) Ratio: 3.4 (good) Also, TSH 1.1, FT4: 16 BUT FT3 2.3.... HELP! LOW Ferritin (21) I know you explain we dont look at one marker in isolation, but if it were you what would you be looking at (min effort, max dose) I do psyllium husk daily (about 10g) and Omega-3 Support as well as the foundations (DESTRESS) Any concerns with cholesterol? 43, Active, healthy, Female :) (Cant run EL labs) x Stephanie: Hi Dr Cabral! I was diagnosed with sjogrens and lupus this year and my dr started me on plaquenil. I am 33 years old and I do not want to be on this medication forever but with being child bearing age and looking to start a family in the next year, they require me to be on it during pregnancy. I have been following your podcast for years and use all of equilife's supplements, follow the quarterly detox, etc. I do the daily foundational protocol and the immunity supplements I use are histpro and mushroom supplement. My understanding of autoimmunity is the immune system is overactive. Are these supplements activating my immune system too much? What are your suggestions I do to help be able to put my autoimmune into remission? I deal with mostly fatigue, joint/muscle pain. Thank you. Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/3725 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!