Podcasts about hdl

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Strength Changes Everything
The Best Exercises to Lower Cholesterol – The Science Behind Strength Training

Strength Changes Everything

Play Episode Listen Later Aug 19, 2025 19:39


We've been told to run, bike, and diet our way to lower cholesterol, but what if the real game changer is strength training? In this episode, Amy Hudson and Dr. James Fisher unpack the science behind resistance training and why it might be the best exercise to lower cholesterol. They explore what research actually says about lifting weights, LDL reduction, and long-term heart health — and why it might be time to rethink your approach to fitness. Dr. Fisher defines cholesterol--a waxy, hormone-like substance that your body produces and regulates on its own. While it often gets labeled as “bad,” it plays vital roles in hormone production and cell health. Dr. Fisher highlights that what we call “cholesterol” is actually carried in the blood by lipoproteins. LDL (low-density lipoproteins) can clog arteries, while HDL (high-density lipoproteins) helps remove excess cholesterol from the bloodstream. Amy breaks down how LDL is considered the “bad” cholesterol because it can harden and narrow artery walls. In contrast, HDL acts like a cleanup crew, carrying unused cholesterol back to the liver to be broken down or reused. Dr. Fisher discusses a meta-analysis of 69 studies involving over 2,000 people that showed consistent benefits from strength training. Participants saw reductions in total cholesterol, LDL, and triglycerides, along with increases in HDL and adiponectin levels. Amy points out that participants who strength trained saw an average drop in total cholesterol of about 8.5 mg/dL. That's a significant improvement — and it didn't require any changes to diet. Dr. Fisher emphasizes that these changes happened independently of calorie restriction or food tracking. Amy and Dr. Fisher explain that the cholesterol-lowering effects of strength training were consistent, whether people trained once, twice, or three times a week. Frequency mattered less than simply doing the work. Dr. Fisher breaks down one individual study in the meta-analysis that used six months of full-body strength training. The results showed reduced fat mass, decreased LDL, and increased HDL — all strong markers of better metabolic health. The cholesterol improvements were not just a side effect of losing weight or fat. The act of strength training alone led to these changes, regardless of body composition. Amy challenges the common belief that cholesterol is only affected by food or medication. The data shows strength training is a powerful, underused tool to shift your numbers naturally. Learn how strength training offers more than just physical benefits — it's also a stress reliever. Pushing through a high-effort workout helps unload mental baggage, too. Amy and Dr. Fisher explore how dietary choices still matter — and discuss how eggs, red meat, and even wine influence cholesterol levels. They encourage variety and moderation over strict elimination. Dr. Fisher advises people to “eat the rainbow,” meaning to include colorful, nutrient-dense foods in your diet. He cautions that many Western diets are too dominated by fried and processed foods — and lack the diversity our bodies need. Amy and Dr. Fisher conclude that combining smart dietary choices with consistent strength training may be one of the most effective ways to lower cholesterol naturally.     Mentioned in This Episode: The Exercise Coach - Get 2 Free Sessions! Submit your questions at StrengthChangesEverything.com Previous episode - Why Most People Fail in the Gym (And How Supervision With a Personal Trainer Can Help)     This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content.

Higher Density Living Podcast
Your Past Mistakes Are Actually Spiritual Gold - Here's Why (Consciousness Breakthrough)

Higher Density Living Podcast

Play Episode Listen Later Aug 19, 2025 18:50


Episode Summary   In this powerful solo episode, Jason explores why self-compassion isn't just nice—it's literally the fastest path to transformation. He dismantles the toxic myth of "I should have known better" and reveals why judging your past choices keeps you stuck in old patterns. This episode offers both scientific backing and spiritual wisdom on how accepting that you've always done your best with what you had can free up massive energy for creating your future.   Key Takeaways The Myth of "Should Have Known Better" The spiritual poison: When you say "I should have known better," you're arguing with reality The truth: You made the best decision you could with the level of consciousness you had at that time Reality check: You can't upgrade your past with your current software   The Science of Self-Compassion Dr. Kristin Neff's research: Self-compassion leads to higher standards and better performance than self-criticism Neurological impact: Self-judgment activates threat detection and shuts down the prefrontal cortex (learning center) Self-compassion benefits: Activates the caregiving system, floods brain with oxytocin, releases neuroplasticity for transformation   The Spiritual Dimension Universal law: Consciousness evolves through experience, not judgment Buddhist concept: Beginner's mind—every moment is a fresh start Soul purpose: Your soul didn't incarnate to live a perfect life, but a full life Wisdom creation: Regret is just wisdom trying to be born   Generational Healing Breaking chains: When you practice self-compassion, you heal an entire lineage Ancestral patterns: Most patterns you judge yourself for were inherited Radical service: Self-compassion is the most radical act of service you can perform   Practical Application: The Three-Step Process   Step 1: Catch Yourself in Self-Judgment   Ask for help recognizing when you're "shoulding" on yourself   Step 2: Ask Three Self-Aware Questions What did I know then? What was my capacity then? What was I dealing with then?   Step 3: Use the Sacred Phrase   "I did what I knew how to do" Put this on your mirror Carry it in your pocket Say it every time you catch self-judgment   Bonus Practice: Get Curious Instead of Judgmental   Replace "Why did I do that?" with: "What was this choice trying to teach me?" "What was my soul learning through that experience?"   Powerful Quotes from This Episode "You can't know what you don't know until you know it." "Self-judgment is just ego trying to time travel." "You can't punish your past self into being better. You can only love your present self into growing." "The voice that heals you is never the same voice that hurts you." "You can't heal what you judge." "You can only choose victim or victor, but you can't choose both." "Your past doesn't define you, it refines you."   Scientific & Spiritual References Dr. Kristin Neff: Self-compassion research and psychological safety Buddhist wisdom: Beginner's mind concept New Testament teaching: "Judge not lest you be judged" Rudolf Steiner: "We're all angels in training"   24-Hour Challenge   Every time you catch yourself in self-judgment: Pause and breathe Say: "I did what I knew how to do. I am learning and growing. I'm exactly where I need to be."   Connect with HDL Podcast   If this episode gave you permission to stop being your own worst enemy, share it with someone who needs to hear it. Remember: you did what you knew how to do—now you know more, now you can do more, but always with compassion for the journey.   Listener Action Items Write "I did what I knew how to do" on your mirror Practice the three self-aware questions when judgment arises Share this episode with someone who's being hard on themselves Join the HDL community for deeper discussions on self-compassion   This episode aligns with HDL Podcast's mission to provide grounded spirituality for the modern seeker—offering both open-hearted curiosity and critical discernment on the journey of conscious living.  

Low Carb MD Podcast
Un-Complicating Cholesterol and Cardiovascular Disease | Josh Wageman - E407

Low Carb MD Podcast

Play Episode Listen Later Aug 11, 2025 62:56


Josh Wageman is a board-certified Clinical Lipid Specialist dedicated to transforming the way we understand and treat heart disease. With a deep expertise in cholesterol, metabolic health, and cardiovascular risk, he helps patients cut through the noise and take control of their health using evidence-based, personalized strategies. Known for translating complex science into actionable steps, Josh is passionate about prevention and proving that heart disease doesn't have to be inevitable. In this episode, Dr. Brian and Josh talk about… (00:00) Intro (00:32) Josh's interesting and varied career path (04:31) Understanding cardiovascular disease in a nutshell (8:15) Understanding lipoproteins (10:10) Why lipids are controversial and what we can all agree on (12:28) LDL and HDL particles (19:35) Endurance athletes and coronary calcium (29:54) Atherosclerosis, carnivore, and gut dysbiosis (39:46) Advanced lipid panels (40:29) Statins and LDL (44:13) Pros and cons of statins (49:54) Supplements that may be helpful for cardiovascular health (52:44) Rapping and singing about lipids and heart health (55:09) Science and faith; physical health and spiritual health (01:02:25) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Josh Wageman: IG: https://www.instagram.com/wagemanjosh/ Book: https://www.amazon.com/Security-System-Lipid-Neighborhood-Complicating/dp/B0DTJ1HJ4Y Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro Instagram: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

Carnivore Diet
Ep 129 - Dr Kendrick | Eat HIGH FAT for 30 Days: Fix Your Heart (Shocking Effect on LDL Cholesterol)

Carnivore Diet

Play Episode Listen Later Aug 9, 2025 93:57


This episode is brought to you by the ⁠⁠⁠Primal Tallow Balms⁠⁠⁠.Dr Kendrick emphasizes the lack of scientific evidence linking high cholesterol to heart disease and argues that a higher fat diet can have positive effects on health. The discussion also covers the complexities of LDL cholesterol, the importance of understanding various health markers, and the potential effects of adopting a high-fat diet. In this conversation, Dr. Malcolm Kendrick discusses the complexities of heart health, focusing on the role of blood clots, the impact of diet on cardiovascular health, and the misconceptions surrounding cholesterol and statins. He emphasizes the importance of understanding the glycocalyx and its protective role in blood vessels, the benefits of a high-fat diet, and the potential for plaque regression. Kendrick also critiques the use of statins, arguing that their benefits are often overstated and come with significant side effects. Takeaways* Cholesterol is often misunderstood in relation to heart disease.* Changing medical opinions is challenging due to entrenched beliefs.* High-fat diets can have positive health impacts.* LDL cholesterol is often mischaracterized as harmful.* The relationship between dietary fat and heart health is complex.* Markers like triglycerides and HDL are important for assessing heart health.* Insulin resistance is a key factor in heart disease risk.* The disease process in arteries can take decades to develop.* LDL levels can be influenced by carbohydrate intake, not just fat.* Understanding the nuances of cholesterol can empower patients. Blood clots form on artery walls and can lead to heart disease.* A high-fat diet can improve blood sugar levels and overall health.* The glycocalyx is crucial for protecting blood vessels from damage.* Diabetes damages the glycocalyx, increasing heart disease risk.* A 30-day high-fat diet can lead to significant health improvements.* Stopping the progression of plaque is more important than regression.* Statins may increase nitric oxide but have many adverse effects.* The average increase in life expectancy from statins is minimal.* Challenging your doctor about statin use can be beneficial.* Understanding the true causes of heart disease is essential for prevention.

The MindBodyBrain Project
Why your LDL cholesterol is not the best predictor of heart disease risk - and what is!

The MindBodyBrain Project

Play Episode Listen Later Aug 8, 2025 42:29 Transcription Available


In this solo episode, I delve deep into a topic that could revolutionise your understanding of cardiovascular health. The focus shifts from the conventional marker, LDL cholesterol, to a more predictive measure that has been right under our noses. Prepare to have your mind blown as I unpack decades of research, dismantles myths, and unveil practical steps for a healthier life. What You'll Learn: The Real Marker of Risk: Discover a much stronger predictor of cardiovascular and metabolic disease risk than LDL cholesterol. Challenging Norms: Understand why relying solely on LDL cholesterol is like flipping a coin when assessing heart disease risk. A Game-Changer: Learn about the Framingham study's revelation that this measure is 3 to 5 times more predictive of heart attack risk. Impacts Beyond Heart Health: Find out how this ratio also predicts risk for metabolic diseases like type 2 diabetes. Practical Steps: Explore dietary and lifestyle changes that can improve your key ratio, enhancing overall metabolic health. Key Takeaways: The triglyceride to HDL ratio offers a more accurate risk assessment than focusing solely on LDL cholesterol. Maximising heart and metabolic health involves more than just medication; lifestyle changes play a crucial role. Understanding your body's response to carbohydrates is key to optimising your lipid profile. The medical community's focus on LDL cholesterol is outdated—empower yourself with current research to guide your health decisions. Simple changes such as low-carb diets, exercise, and intermittent fasting can significantly impact your health outcomes. Support the Podcast: If you enjoyed this episode, consider subscribing and leaving a review on your preferred podcast platform. Your support helps us bring valuable conversations like this one to a wider audience. If this perspective on heart health was enlightening, consider sharing it with friends and family. Encourage them to rethink traditional markers of health and embrace more comprehensive measures. Stay connected with the evolving world of cardiovascular research and empower yourself with knowledge for a healthier, longer life. Final Thoughts: Embrace the shift towards a more nuanced understanding of heart health. As we grow more informed, the tools to live healthier, longer lives are within our grasp—let's use them to navigate our health journey intelligently. 00:00 Introduction and Podcast Name Change 01:31 Today's Topic: Cardiovascular Disease and LDL Cholesterol 03:54 The Limitations of LDL Cholesterol 07:52 The Game Changer Ratio 09:01 Research and Studies on this alternative Ratio 17:20 Practical Applications and Lifestyle Changes 29:32 Medications and Advanced Research 41:25 Conclusion and Key TakeawaysSee omnystudio.com/listener for privacy information.

The Most Days Show
Managing Parkinson's and Pre-Diabetes with Dr. Richard Maurer

The Most Days Show

Play Episode Listen Later Aug 8, 2025 50:25


In this episode, Brent sits down with Dr. Richard Maurer, a naturopathic doctor and author of The Blood Code, a book about metabolic health. They discuss markers like A1C, LDL, HDL, triglycerides, and how these impact risks for conditions such as diabetes and heart disease. Dr. Maurer shares his personal journey of reversing prediabetes and provides actionable insights on diet, exercise, and maintaining a balance between endurance and weight training to optimize health. The conversation then shifts to Dr. Maurer's approach to his Parkinson's diagnosis. With a focus on information, community, and proactive measures, he details how he has adapted his lifestyle to slow the progression of this neurodegenerative disease. Hope you enjoy.

Health and Medicine (Video)
Managing Lipid Disorders Like High Cholesterol

Health and Medicine (Video)

Play Episode Listen Later Aug 1, 2025 58:34


Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Cardiology (Video)
Managing Lipid Disorders Like High Cholesterol

Cardiology (Video)

Play Episode Listen Later Aug 1, 2025 58:34


Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

University of California Audio Podcasts (Audio)
Managing Lipid Disorders Like High Cholesterol

University of California Audio Podcasts (Audio)

Play Episode Listen Later Aug 1, 2025 58:34


Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

Health and Medicine (Audio)
Managing Lipid Disorders Like High Cholesterol

Health and Medicine (Audio)

Play Episode Listen Later Aug 1, 2025 58:34


Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

The Dr. Ashley Show
108. 7 Foods That Naturally Lower Bad Cholesterol (No Statins Needed)

The Dr. Ashley Show

Play Episode Listen Later Jul 29, 2025 15:03


As a PhD nutritionist and registered dietitian, I'm breaking down 7 powerful foods that naturally lower bad cholesterol—no statins required. Learn how these foods reduce inflammation, improve HDL, and support heart health, all backed by science and real client results.GET A CUSTOMIZED WEIGHT LOSS PLAN: Have a free 1-on-1 call with our Expert Nutritionists 

Protecting Your NEST with Dr. Tony Hampton
Episode 236: Priming for Health: How Raymond Nazon Beat Disease with a Carnivore Diet

Protecting Your NEST with Dr. Tony Hampton

Play Episode Listen Later Jul 25, 2025 63:36


Welcome to Protecting Your Nest with Dr. Tony Hampton. Raymond Nazon is a carnivore coach and the inventor of the priming concept for the carnivore diet. The list of issues he was experiencing prior to carnivore includes: pre-diabetes, plantar fasciitis, waist size of 44, rosacea, mid-back pain, arthritic knee and finger joints, heel spurs, poor libido, high triglycerides, low HDL, blood pressure, pre-hypertension, snoring, dandruff, acne, diminishing eyesight, poor wound-healing, irritable bowel disease, chronic constipation, constant brain fog, insomnia and more. Now, after following a carnivore diet since 2017, Raymond has been set free to do and be so much more than he ever thought possible.   In this discussion, Dr. Tony and Raymond talk about: (00:00) Intro (04:30) Raymond's carnivore journey—why he started and what he has learned along the way (12:21) How Raymond has been able to stay consistent with his diet over the years (15:19) The concept of ‘priming' for the carnivore diet (19:39) The emotional challenges people face when switching to carnivore (24:46) Spices and seasonings on the carnivore diet (28:28) Non-scale victories Raymond has had following a carnivore diet (31:33) Orange Theory, Karate, Jiu Jitsu, hiking, and running (35:41) Why Raymond shares his message with others (38:57) A truly ASTOUNDING carnivore success story (42:29) Fasting and the carnivore diet (47:40) How Raymond's family has benefited from the carnivore diet (50:15) Increased libido on carnivore (52:38) The MYTH about carnivore and heart disease (55:34) Outro Thank you for listening to Protecting Your Nest. For additional resources and information, please see the links below.   Links:   Resources Mentioned in this Episode: The Steak and Butter Gang: https://sbg-s-meat-up.mn.co Dr. Tony's video on Carnivore Priming: https://www.youtube.com/watch?v=6IL6KsHgtTU   Raymond Nazon: YouTube: https://www.youtube.com/channel/UC8l7xBJzug3R6lDYz1dhigw FB: https://www.facebook.com/rnazon/ IG: https://www.instagram.com/raymondnazon/?hl=en Email: rnazon@gmail.com 90 Day Challenge: https://sbg-s-meat-up.mn.co/plans/316276?bundle_token   Dr. Tony Hampton: Linktree: https://linktr.ee/drtonyhampton Instagram Account: https://www.instagram.com/drtonyhampton/ LinkedIn Account: https://www.linkedin.com/in/drtonyhampton/ Ritmos Negros Podcast: https://podcasts.apple.com/us/podcast/ritmos-negros/id1534043495 Q Med: https://qmedcme.com Symposium for Metabolic Health Lectures: https://www.lowcarbusa.org/smhp-symposiums/san-diego-2022/ How Waking Up Every Day at 4:30 Can Change Your Life: https://www.youtube.com/watch?v=qOEB1Fr0_MM • • Keto Mojo: https://keto-mojo.com/speakers/tony-hampton/

Crazy Wisdom
Episode #473: Breaking the Parasite Spell: Metabolic Healing and Remembering Who We Are

Crazy Wisdom

Play Episode Listen Later Jul 21, 2025 58:12


On this episode of Crazy Wisdom, Stewart Alsop talks with Larry Diamond, co-founder of Healing with the Diamonds, about his journey from severe metabolic illness to vibrant health and his work helping others do the same. They explore topics like heart-brain coherence, the alchemical journey, insulin resistance, seed oils, and the deeper spiritual dimensions of healing, weaving in references to David Hawkins, Rupert Sheldrake, and the lost wisdom of the divine feminine. Larry shares insights on metabolic testing, ancestral eating, and the importance of authentic living, while also touching on the role of parasites—his term for the forces keeping humanity in fear and incoherence. You can find more about Larry and his work, as well as access his consulting, at healingwiththediamonds.com, on Instagram and Facebook at Healing with the Diamonds, or listen in iTunes to his upcoming podcast.Check out this GPT we trained on the conversationTimestamps00:00 Stewart Alsop introduces Larry Diamond of Healing with the Diamonds; they discuss his healing journey, health coaching, and the meaning of heart-brain coherence.05:00 Alchemical journey, crystals, the hero's journey, integrating masculine and feminine energies, and the idea of parasites feeding on fear.10:00 Kindness vs niceness, morphic fields, Rupert Sheldrake's theories, and quantum entanglement as evidence of interconnectedness.15:00 Scientism vs true science, metabolic illness, citizen science, Larry's 2013 health transformation.20:00 Metabolic syndrome, C-reactive protein, fasting insulin, insulin resistance, and Larry's weight loss story.25:00 Seed oils, refined carbs, ultra-processed foods, and strategies for restoring metabolic health.30:00 Carb cycling, primal eating, intuitive healing, and ancestral wisdom.35:00 Spirituality beyond religion, Yeshua vs Jesus, divine feminine, and writing your own gospel.40:00 Living authentically, kindness in daily life, and finding healing in sovereignty and connection.Key InsightsLarry Diamond shares how his journey from severe metabolic illness to vibrant health became the foundation for Healing with the Diamonds. He explains how hitting rock bottom in 2013 inspired him to reject mainstream dietary advice and embrace a primal, whole foods approach that reversed his insulin resistance and helped him lose over 100 pounds.A major theme of the conversation is heart-brain coherence, which Larry describes as essential for true wisdom and discernment. He connects this to ancient teachings, referencing Yeshua's “sword of discernment” and suggesting that Western culture intentionally suppressed this knowledge to keep people in fear and mental fragmentation.The episode explores the alchemical journey as a metaphor for inner transformation, likening it to Joseph Campbell's hero's journey. Larry emphasizes integrating masculine and feminine energies and overcoming ego as key steps in remembering our divine nature and embodying authenticity.Larry critiques scientism, which he calls the inversion of true science, and encourages listeners to reclaim citizen science as a path to health sovereignty. He shares practical tools like testing for C-reactive protein, A1C, fasting insulin, and using triglycerides-to-HDL ratios to assess metabolic health.He identifies the “Big Four” dietary culprits—seed oils, refined carbs, ultra-processed foods, and sugar—as drivers of chronic illness and advocates returning to ancestral foods rich in natural fats and nutrients. He stresses that flavor and enjoyment are critical for sustainable healing.On the spiritual side, Larry reframes the Abrahamic religions as distortions of deeper wisdom traditions, contrasting the figure of Yeshua (aligned with love and sovereignty) with the institutionalized Jesus narrative. He highlights the divine feminine, Sophia, as a source of intuition and co-creation with the cosmos.Finally, Larry encourages listeners to “write your own gospel and live your own myth,” seeing authentic, kind, and sovereign living as both a spiritual and practical act of resistance to what he calls the parasite class—forces of fear and manipulation seeking to block human awakening.

Podcast Notes Playlist: Nutrition
#104 Dr. Ben Bikman: How To Reverse Insulin Resistance Through Diet, Exercise, & Sleep

Podcast Notes Playlist: Nutrition

Play Episode Listen Later Jul 19, 2025 181:02


Found My Fitness - Rhonda Patrick Key Takeaways  To some degree, insulin resistance is a common root cause for most chronic diseases A low-carb diet may offer a metabolic advantage by reducing insulin levels, which enhances metabolic flexibility and improves energy regulationFat tissue has a much higher metabolic rate when insulin levels are lowSince there is much more metabolic uncoupling, the body's engine revs up to burn energy just to create heat   How to reverse a diabetes diagnosis in 90 days Control carbs – focus on whole fruits and vegetables, limiting sugary or starchy choices like bananas, pineapples, and mangoes Prioritize protein and do not fear fat – eat protein-rich foods regularly, and do not worry too much about naturally occurring fats Time meals and exercise – Eat more calories earlier in the day, avoid late-night eating, and take short walks after your biggest meals to reduce blood sugar spikesEating an evening snack spikes your blood sugar and ramps up the sympathetic nervous system, thus increasing body temperature and increasing the likelihood of insomnia and poor sleep; so do not eat within the 3-4 hours before bed Muscle is a great glucose consumer: The more muscle you have, the more metabolic wiggle room you have because muscle serves as a glucose sink Blood-sugar-lowering supplements that work:magnesium,alpha lipoic acid (ALA),berberine, andapple cider vinegar Eating too much linoleic acid (from seed oils) can lead to the production of a toxic substance (4H&E) that prevents your body from creating new small fat cells, and instead forces existing fat cells to just swell upConcerning GLP-1 dosing, caution is warranted; it is probably better to microdose these powerful drugs and think of them as short-term behavioral modification tools instead of lifelong prescriptions  The top biomarkers to measure to determine metabolic health and aging:(1) fasting insulin; want below 6 µIU/mL), (2) Triglyceride-to-HDL ratio; want ratio under 1.5, and (3) Uric acid; want lower levels generallyLower your insulin by starting with tomorrow's breakfast: Either fast through breakfast and drink coffee, tea, or yerba mateOr if you do want to eat, then choose low-glycemic-load vegetables and berries, and consume more protein and fat  Do whatever you can to keep your insulin in check for as long as possible throughout the day; the longer the insulin is low, the more you will improve your insulin sensitivity Read the full notes @ podcastnotes.org Get access to 130 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunction and highlights actionable, evidence-based tactics for improving metabolic health. Ben also addresses pressing questions about popular weight loss medications like Ozempic and other GLP-1 agonists: Are they groundbreaking solutions, or shortcuts with hidden metabolic consequences? Timestamps: (0:00) Introduction (4:51) Can you be insulin resistant with normal glucose levels? (8:30) Can glucose monitors detect hidden insulin resistance? (10:01) What your skin reveals about insulin resistance (11:25) Why is insulin resistance behind so many chronic diseases? (15:46) Does obesity cause insulin resistance—or vice versa? (22:38) Insulin's surprising roles beyond blood sugar control (23:36) What's driving weight gain—insulin or calories? (30:30) Do saturated fats cause insulin resistance? (37:02) Why refined carbs amplify risks from saturated fat (40:04) Fructose vs. refined sugar—which spikes insulin more? (41:01) High-carb vs. keto—which diet controls hunger better? (45:27) Why low-carb diets might provide a metabolic advantage (47:36) Does exercise give you metabolic ‘wiggle room'? (52:00) Why strength training beats cardio for insulin sensitivity (54:03) Should you lower insulin before cutting calories? (57:12) Does meal frequency drive insulin resistance? (1:00:32) Is nighttime snacking giving you insomnia? (1:02:24) Can a sugary breakfast lead to overeating later? (1:07:19) Does late-night eating disrupt sleep more than blue light? (1:08:59) Can one bad night's sleep trigger insulin resistance? (1:12:23) Can air pollution cause weight gain? (1:16:15) Vaping vs. smoking—which is worse for metabolic health? (1:17:40) Can statins and antidepressants trigger weight gain? (1:20:22) How to reverse insulin resistance in 90 days (1:26:59) Does apple cider vinegar really lower blood sugar? (1:30:54) Ketone supplements—are the metabolic benefits real? (1:36:34) Why some ethnicities get diabetes without obesity (1:44:28) How oversized fat cells trigger metabolic chaos (1:49:28) Do seed oils silently promote insulin resistance? (1:52:44) Seed oils—always harmful or only when heated? (1:58:35) Fat, muscle, or liver—where does insulin resistance start? (2:04:21) Do fat cells shrink or disappear with weight loss? (2:07:05) Are shrunken fat cells still insulin resistant? (2:08:15) Can exercise and cold therapy specifically shrink visceral fat? (2:09:40) Injecting insulin for muscle—are the risks worth it? (2:12:45) Are drugs like Ozempic a shortcut or solution for obesity? (2:19:12) Are current GLP-1 agonist doses too high? (2:20:02) Microdosing GLP-1 drugs—a solution for carb cravings? (2:26:01) Do these medications cause muscle loss—or is it poor nutrition? (2:28:30) Do GLP-1 agonist benefits extend beyond weight loss? (2:30:41) Could these treatments actually promote longevity? (2:36:12) The dark side of GLP-1 drugs—can they trigger depression? (2:39:31) Insulin vs. glucose—what really drives accelerated aging? (2:44:34) How high glucose levels damage cells—from glycolysis to sorbitol (2:46:40) How insulin shuts down your body's stress defenses (2:51:15) Which biomarkers best predict biological aging? (2:55:05) One simple breakfast change to lower insulin (2:57:19) Does eating dinner early improve insulin sensitivity? Show notes, transcript, and summary are available by clicking here Watch this episode on YouTube

Phil Hugo Fitness and Mindset Podcast ESPAÑA
PHFM236 Lean Mass Hyperresponders: el fenotipo que desafía a la cardiología clásica

Phil Hugo Fitness and Mindset Podcast ESPAÑA

Play Episode Listen Later Jul 13, 2025 31:34


Optimiza tu LDL Colesterol e interpreta tu analítica o las de tus pacientes hoy, sin fármacos, aplicando estrategias nutricionales y suplementos clave con dosis y ciencia. Accede aquí:https://philhugo.com/producto/ldl-colesterol/  ¡Te espero dentro!Los suplementos be levels mencionados que formulo personalmente: Tu código de descuento: INTERGALACTICOBerberina: https://shop.belevels.com/products/berberine?sca_ref=745165.uf0cpcacla Omega 3: https://belevels.com/products/omega3?sca_ref=745165.uf0cpcaclaTriple Magnesio: https://belevels.com/products/magnesium?variant=47417739379012.uf0cpcacla Dosis y los demás explicados en el curso de Control Absoluto del LDL Colesterol.¿Sigues una dieta cetogénica estricta y tu LDL se ha disparado a niveles que asustarían a cualquier médico? No estás solo. En este episodio, desentrañamos la fisiología del Lean Mass Hyperresponder (LMHR): un perfil metabólico donde el colesterol LDL se eleva no por enfermedad, sino por eficiencia energética. Aprende cómo tu hígado, en ausencia de glucosa, convierte grasa en combustible a través de VLDL y LDL. Descubre por qué un LDL de 300 mg/dL puede ser normal si tu HDL está alto, tus triglicéridos bajos y tu inflamación es cero. Estudio a estudio, desmonto los miedos injustificados y propone estrategias clínicas reales para modular tu LDL si es necesario, desde el aumento de carbohidratos limpios hasta la optimización tiroidea y muscular. Este episodio no es para quien se conforma con los rangos de laboratorio estándar. Es para quien quiere entender su cuerpo desde la lógica metabólica y tomar decisiones con ciencia, no con miedo.ReferenciasApoB es biomarcador y posible diana terapéutica cardiovascular. Behbodikhah, Jennifer et al. “Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.” Metabolites vol. 11,10 690. 8 Oct. 2021LDL sube mucho en "lean mass hyper-responders" con dieta baja en carbohidratos. Norwitz, Nicholas G et al. “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype.” Current developments in nutrition vol. 6,1 nzab144. 30 Nov. 2021Marcadores tiroideos y composición corporal predicen cambios en LDL con dieta cetogénica. Cooper, Isabella D et al. “Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.” Frontiers in endocrinology vol. 14 1326768. 21 Dec. 2023Omega-3 mejora dislipidemia en relación dosis-respuesta. Wang, Tianjiao et al. “Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.” Journal of the American Heart Association vol. 12,11 (2023): e029512.Omega-3 de prescripción tiene efectos lipídicos beneficiosos. Bays, Harold E et al. “Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications.” Expert review of cardiovascular therapy vol. 6,3 (2008): 391-409La berberina reduce lípidos, sola o combinada. Koppen, Laura M et al. “Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review.” Journal of evidence-based complementary & alternative medicine vol. 22,4 (2017): 956-968.Niacina baja lipoproteína(a) según fenotipo de apo(a). Artemeva, N V et al. “Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype.” Atherosclerosis. Supplements vol. 18 (2015): 53-8

Dr. Joseph Mercola - Take Control of Your Health
The Fruit That Transforms Your Gut in Weeks - AI Podcast

Dr. Joseph Mercola - Take Control of Your Health

Play Episode Listen Later Jul 12, 2025 7:39


Story at-a-glance Dragon fruit delivers antioxidant protection, gut support, and metabolic benefits, making it an easy way to upgrade your fruit intake Research shows that 100 grams of dragon fruit, about 1/2 cup, daily lowers LDL cholesterol by up to 69%, raises HDL by over 60%, and reduces triglycerides within weeks Bioactive compounds in the flesh, seeds, and even peel help fight inflammation, protect your liver, and feed beneficial gut bacteria like Akkermansia and Lactobacillus Dragon fruit's natural sugars provide steady energy without blood sugar crashes, making it an ideal pre-workout snack or midday pick-me-up It's especially helpful for pregnancy, digestive sluggishness, and skin repair, thanks to its folate content, natural hydration, and collagen-boosting vitamin C

Doctor Warrick
EP394: The REAL Truth About Cholesterol

Doctor Warrick

Play Episode Listen Later Jul 12, 2025 10:45


Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the importance of understanding cholesterol in his podcast. He explains that cholesterol is crucial for cell membranes, hormone formation, and vitamin transport, and that LDL and HDL are transport vehicles for cholesterol. Dr. Bishop clarifies that cholesterol's impact on heart health is complex, as high LDL doesn't always indicate artery plaque, and low cholesterol doesn't always mean healthy arteries. He emphasizes the importance of coronary artery calcium scoring, particle numbers, and other factors in assessing artery health and predicting risk. For secondary prevention, lowering cholesterol is crucial, while primary prevention requires a personalized approach, considering individual risk factors and imaging.

Proven Health Alternatives
Decoding Your Metabolic Health: A Deep Dive into MVX Testing

Proven Health Alternatives

Play Episode Listen Later Jul 3, 2025 40:42


In this episode of Proven Health Alternatives, I sit down with Dr. Darren Schmidt to explore one of the most promising tools in functional medicine today: the MVX Plus test. Launched in 2025, this next-gen blood panel goes far beyond standard labs—offering a deeper lens into chronic inflammation, mitochondrial dysfunction, nutrient deficiencies, and more. Dr. Schmidt breaks down the six core markers—from GlycA to citrate to branched-chain amino acids—and explains how they uncover hidden vulnerabilities affecting your healthspan. We also dive into practical insights, like the importance of vitamin B1, the dangers of ultra-processed diets, and how MVX can detect issues even when standard tests look “normal.” If you're serious about optimizing longevity, identifying root causes, or catching problems before they escalate—this episode is packed with the clinical gold you've been waiting for. Key Takeaways: Understanding MVX Plus: MVX Plus measures pivotal factors like Glyc A, small HDL particles, and branched-chain amino acids to offer a nuanced assessment of chronic diseases and longevity. Importance of B1: Dr. Schmidt underscores the critical role of Vitamin B1 in managing metabolic health and shares his dramatic recovery story from a gas leak-induced health crisis. Seven-Step Program: This comprehensive framework targets diet, energy, and detoxification to systematically improve health outcomes as indicated by MVX Plus results. Clinical Implications: Real-world examples emphasize how timely intervention based on MVX test results can dramatically affect a patient's health trajectory. Holistic Health: The episode advocates for a return to holistic practices and the understated value of nutrition, particularly protein-rich diets, in combating malnutrition. More About Dr. Darren Schmidt: Dr. Darren Schmidt, D.C. is the founder of the Nutritional Healing Center of Ann Arbor, the largest non-insurance nutrition clinic in the U.S. His 7-Step Blueprint to Optimal Health and MVX Plus blood test position him as a leader in root-cause foundational nutrition. He began practicing in 1997 and was early to adopt low-carb, keto, and carnivore—while always focusing on detox, nourishment, and restoring function. In 2005, he stopped accepting insurance to ensure clinical results weren't compromised. He has delivered over 100 seminars to 10,000+ healthcare professionals and continues to advance natural solutions for chronic disease. Website Instagram How MVX Can Help YouTube Connect with me! Website Instagram Facebook YouTube This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more!

Doctor Warrick
EP392: HDL, Vitamin D, and Triglycerides

Doctor Warrick

Play Episode Listen Later Jun 28, 2025 13:47


Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses key health topics related to heart disease, which significantly impacts Australia. He emphasizes the importance of understanding blood pressure, weight, and cholesterol to improve health outcomes. The discussion highlights high-density lipoprotein (HDL), often labeled as "good cholesterol," noting that while higher levels are generally protective, some individuals with genetically high HDL may actually face increased heart disease risk if the HDL is not functional.

Dr. Joseph Mercola - Take Control of Your Health
Your Brain on Fake Meat: The Link to Depression - AI Podcast

Dr. Joseph Mercola - Take Control of Your Health

Play Episode Listen Later Jun 19, 2025 9:21


Story at-a-glance A study found that vegetarians who ate plant-based fake meat are 42% more likely to experience depression than those who don't, even when factors like age, BMI, and lifestyle are taken into account Eating fake meat leads to higher levels of C-reactive protein (CRP), a marker of systemic inflammation linked to chronic diseases like heart disease, diabetes, and autoimmune disorders Triglycerides were elevated and HDL cholesterol was lower in those eating fake meat, increasing their long-term risk for cardiovascular disease The body reacts to fake meat not because of its nutrients, but because of ultraprocessed ingredients and additives that disrupt immune signaling and metabolic function Even when blood nutrient levels appear normal, the deeper immune system activity reveals that fake meat is pushing your body toward inflammation and oxidative stress

Trensparent with Nyle Nayga
Dr. Dean: Health & Steroids - Avoiding Death to Sleep to Hair Restoration

Trensparent with Nyle Nayga

Play Episode Listen Later Jun 15, 2025 203:25


PhD in synthetic chemistry, the Product Formulator for Supplement Needs, and fitness industry renowned Pharmacologist for his no-nonsense approach in bodybuildingThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com2:19 Bodybuilding Pharmacology and Dosing4:53 Brain Health and Long-Term Risks7:29 Muscle Building and Genetic Factors10:03 Cholesterol and LDL Impacts12:14 Podcast Setup and Equipment Upgrades14:34 Hair Transplant Journey24:23 Hair Loss Causes and Treatments34:59 Post-Transplant Recovery and Rebound39:31 Epigenetics and Muscle Memory43:04 Ethical Questions on Genetic Enhancement45:40 Enhanced Games Debate50:09 Dosing Challenges in Enhanced Sports52:32 Data Collection and Human Experimentation55:16 Genetic Variance and Elite Athletes59:04 Neurodegeneration and PEDs1:07:08 Oxidative Stress in Bodybuilding1:09:37 Sleep and Brain Detox1:18:01 Nutrition for Oxidative Stress1:19:02 Melatonin as an Antioxidant1:21:13 Melatonin Dosing and Effects1:24:51 Melatonin and Sleep Support Supplements1:28:22 Magnesium and Sleep Health1:31:23 Sleep Apnea and Neural Health1:36:30 Frequent Urination at Night1:46:33 Overheating During Sleep1:59:14 Wrapping Up Oxidative Stress2:00:33 Neuron Loss and Neurotransmitters2:02:04 Boosting Brain Health with BDNF2:04:08 Peptides for Neural Growth2:09:14 Oxidative Stress and Supplements2:12:34 Neuroprotection Strategies2:19:56 EMF and Environmental Stressors2:22:12 Mitochondrial Dysfunction and Aging2:24:55 Balancing Oxidative Stress2:28:32 Steroids and Muscle Growth Rates2:38:54 HDL and LDL Control Ancillaries2:41:34 Statins and LDL Oxidation2:47:36 Antioxidants and Plaque Formation2:54:10 Balancing Cholesterol Levels2:58:35 CT Scans for Heart Health3:03:54 Heart Health Supplements3:06:48 Mitochondrial Stack Under 303:16:27 Balanced Diet in Prep3:20:24 Omega-3 and Fish Oil Quality3:23:36 Podcast Wrap-Up

Optimal Health Daily
3012: How Genetics Impact HDL and LDL Cholesterol and Targeted Lifestyle Strategies to Improve Wellbeing

Optimal Health Daily

Play Episode Listen Later Jun 13, 2025 13:55


Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3012: Dr. Neal breaks down the role of genetics in cholesterol levels and explains how even those with a family history of heart disease can benefit from targeted lifestyle changes. From diet tweaks to exercise strategies, his practical tips empower listeners to take control of their heart health, no matter their DNA. Quotes to ponder: "HDL actually helps the body clear LDL from the arteries, which is why it's good." "One of the most effective ways to lower blood cholesterol and blood pressure quickly is weight loss." "Fiber is so helpful because it helps bind to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids (NIH Office of Dietary Supplements): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer USDA FoodData Central: https://fdc.nal.usda.gov/ National Heart, Lung, and Blood Institute: https://www.nhlbi.nih.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

Optimal Health Daily - ARCHIVE 1 - Episodes 1-300 ONLY
3012: How Genetics Impact HDL and LDL Cholesterol and Targeted Lifestyle Strategies to Improve Wellbeing

Optimal Health Daily - ARCHIVE 1 - Episodes 1-300 ONLY

Play Episode Listen Later Jun 13, 2025 13:55


Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3012: Dr. Neal breaks down the role of genetics in cholesterol levels and explains how even those with a family history of heart disease can benefit from targeted lifestyle changes. From diet tweaks to exercise strategies, his practical tips empower listeners to take control of their heart health, no matter their DNA. Quotes to ponder: "HDL actually helps the body clear LDL from the arteries, which is why it's good." "One of the most effective ways to lower blood cholesterol and blood pressure quickly is weight loss." "Fiber is so helpful because it helps bind to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids (NIH Office of Dietary Supplements): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer USDA FoodData Central: https://fdc.nal.usda.gov/ National Heart, Lung, and Blood Institute: https://www.nhlbi.nih.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

Sky Women
Episode 208: New WHI Data: Hormone Therapy Shows Favorable Long-Term Heart Effects

Sky Women

Play Episode Listen Later Jun 8, 2025 9:25


In this episode, Dr. Carolyn Moyers breaks down the latest original research from the April 2025 issue of Obstetrics & Gynecology, focusing on the long-term cardiovascular biomarker changes in women who participated in the Women's Health Initiative Hormone Therapy Trials. What does this mean for real-life patients considering hormone therapy? Are there age-related risks? What's the deal with triglycerides?Dr. Moyers explores the clinical relevance of these findings, limitations of the data, and the questions that still remain—offering an evidence-based, patient-centered perspective for women navigating menopause and their heart health.

The Lens Pod
The Lens Newsletter: June 4, 2025

The Lens Pod

Play Episode Listen Later Jun 4, 2025 9:14


Too busy to read the Lens? Listen to our weekly summary here! In this week's episode we discuss:Both high and low levels of HDL were associated with increased risk of AMD, though the mechanism for this remains unclear.A majority of ophthalmic subspecialists practice in urban areas, and this trend has increased over the last decade.Study compares 5 modern toric IOL formulas for cataract patients with astigmatism.Systemic GLP-1 inhibitor treatment was found to reduce size and leakage of CNVM lesions in mouse models.

Primal Foundations Podcast
Episode 55: Beyond the Prescription - The Carnivore Diet with Ankur Verma

Primal Foundations Podcast

Play Episode Listen Later Jun 1, 2025 58:08 Transcription Available


Send us a textDr. Ankur Verma, an emergency medicine specialist from New Delhi and host of The DESI EM Project podcast, shares his compelling journey from a carb-heavy Indian diet to embracing a carnivore lifestyle after facing severe metabolic health issues. By adopting a meat-based diet, he reversed his own metabolic syndrome and witnessed remarkable health improvements in others, including his uncle's reversal of 25 years of diabetes. Dr. Verma challenges conventional nutritional wisdom by emphasizing the importance of biomarkers like triglyceride-to-HDL ratio and homocysteine levels over traditional cholesterol metrics. Through his podcast, he delves into topics such as emergency medicine, nutrition, and the influence of pharmaceutical interests on medical education, advocating for a root-cause approach to health. Follow his insights on Instagram @thecarnivore.epConnect with Ankur:@thecarnivore.epDesi EM Project - Spotify Desi EM Project - Apple  Support the showPRIMAL FOUNDATIONS PODCAST-Instagram: @Tony_PrimalFoundationsWebsite: Primalfoundations.com The Strength Kollective: Download Kettlebell Programs (Click Here)Book a free 30 minutes consultation (Click Here)

Phil Hugo Fitness and Mindset Podcast ESPAÑA
PHFM231 Mi colesterol subió a 270 en KETO y esto fue lo que pasó

Phil Hugo Fitness and Mindset Podcast ESPAÑA

Play Episode Listen Later Jun 1, 2025 11:39


Te explico todo sobre la famosa "triada cetogénica": colesterol LDL elevado, triglicéridos bajos y HDL alto, un patrón común en quienes siguen una nutrición cetogénica bien ejecutada. Detallo cómo esta triada, lejos de ser peligrosa, puede reflejar un estado metabólicamente saludable, especialmente cuando se acompaña de un bajo porcentaje de grasa corporal, buenos hábitos y una dieta rica en omega-3 y verduras. También hablo de los errores más comunes en la interpretación de analíticas y el uso excesivo de estatinas sin evaluar el contexto clínico del paciente.

Dr. Joseph Mercola - Take Control of Your Health
Beyond Statins: Lowering Cholesterol Naturally and Safely - AI Podcast

Dr. Joseph Mercola - Take Control of Your Health

Play Episode Listen Later May 28, 2025 6:20


Story at-a-glance Cholesterol is essential for hormone production, brain function, and cell health, and about 80% of it is made by your body — not consumed in food. High triglycerides, not total cholesterol, pose a stronger risk for heart attack — raising risk by 80% — making triglyceride-to-HDL ratio a better heart disease predictor Newer science shows chronic inflammation — not LDL alone — may be the real cause of plaque buildup in arteries, shifting focus to markers like ApoB and CRP Natural options like garlic, artichoke, bergamot, plant sterols, green tea, and oats have been shown in clinical studies to lower LDL cholesterol and improve heart markers Red yeast rice can lower LDL by up to 33%, but it contains a statin-like compound with the same side effects and potential kidney toxins like citrinin Lifestyle changes like cutting sugar, walking daily, and sleeping well can activate the Pareto Principle — where 20% of effort yields 80% of results in lowering cholesterol. Exercise improves five key metabolic biomarkers — glucose, HDL, triglycerides, blood pressure, and waist size — each linked to long-term cardiovascular health

The Cabral Concept
3396: Healthier Joints, High LDL & Statins, Improving Kidney Function, Reducing Aluminum, Magnesium & Cortisol (HouseCall)

The Cabral Concept

Play Episode Listen Later May 24, 2025 17:17


Welcome back to our weekend Cabral HouseCall shows!   This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track!   Check out today's questions:     Kellie: Hi Dr. Cabral! I have been with your program for almost 6 months now. I have completed the Vit-Tox tests and have gone through the FM Detox twice and now going through the CBO Protocol. I just turned 38 years old and I feel like my joints are of an 80 year old. I have played soccer since age 5 and still play on a competitive coed league to this day. I have played many other team/contact sports in the past. I have had past ankle, knee, and hip injuries due to sports and I do see possible knee and hip replacements in my future. When I do my daily workouts or go up/down stairs my ankles, knees, hips, and back crack or pop so easily and so much. I don't see glucosamine chondroitin as a supplement in your shop. Are there any suggestions you may have to keep my joints healthier? Thank you!!              Jon: Hey Dr Cabral, looking for advice and i feel like there's a population that struggles with this same topic. My Dr is recommending a statin due to my high LDL-C of 230. My LDL has gone up after cleaning up my diet in the last 7 months however ALL of my markers tested for have improved. Triglycerides have gone from over 200 to 100, HDL is up to 60, VLDL has dropped from 30 to 15, A1C is 5.2, blood pressure is normal for the first time ever, and so onr. My personal opinion is that i'm healthier than ever and i can't imagine having to go on what seems like a lifetime drug due to one marker being off and i don't buy the story that LDL alone is a concern for me. Curious on your opinion here and if you think i have something to worry about. Thanks!!                                                                                                                            Annette: I've been diagnosed with nephrocalcinosis by conventional doctors who say the cause is genetic. I have adjusted my diet to low sodium, low oxalate foods. The doctors say my next step is to try to get on the kidney transplant list before I need dialysis. I take potassium citrate and a calcitriol. Is there anything I can do to improve my kidney function?                                                                                                  Summer: Hi Dr. Cabral! I heard you say that it's best to replace aluminum cookware, but not necessary, and instead to use parchment paper as a barrier. Doesn't the aluminum off gas when heated? How does parchment paper prevent the aluminum from getting into the food? Thanks! By the way, to all my fellow listeners: please contact your state representatives and let them know you do not consent to geo-engineering in your skies. Several states have now banned it. We could all live healthier lives if we could work toward eliminating toxins and heavy metals including aluminum that are regularly being sprayed into our air.                                                                                                                                                Ann: Thank you Dr Cabral- you are changing SO many lives - thank you for all of your wisdom and teachings:) I have a question about Magnesium. My cortisol was high at my last lab test, and I took Full Spectrum magnesium for 12 weeks, and now I take Cal Mag daily. I also understand that I can take Calming Magnesium and CBD at night to help with sleep.I don't want to take too much for too long for my body, but I still think I need the help for my cortisol levels/ sleep. What combination of the above do you recommend? Is there a length of time that is too long to be on Full Spectrum Magnesium? PS. I do the 3-2-1 protocol, take Adrenal Soothe and will be repeating my big 5 this fall. Thank you again!           Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!      - - - Show Notes and Resources: StephenCabral.com/3396 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

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Boundless Body Radio
Clarifying the KETO-CTA Study with Dr. Adrian Soto-Mota, PhD!

Boundless Body Radio

Play Episode Listen Later May 21, 2025 67:02


Send us a textDr. Adrian Soto-Mota is a returning guest on our show! Be sure to check out episode 138 of Boundles Body Radio, which was part of a special series we did, featuring Dr. Nick Norwitz as the guest host!We also hosted Dr. Soto-Mota on episode 340, episode 419, and episode 599 of our show!Dr. Soto-Mota is a MD PhD & Specialist in Internal Medicine and Data Science researcher at the Unidad de Investigación de Emfermedades Metabólicas! Dr. Soto-Mota is passionate about studying low carbohydrate and ketogenic diets, and how they impact human metabolism.Dr. Soto-Mota earned his MD from the Universidad Nacional Autónoma de México, and earned his Ph.D. at Oxford. He has created many resources to help people successfully implement a low carbohydrate diet, and provides that help for both English and Spanish speaking individuals.He is the co-author of a 2022 paper titled The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets, and the co-author of the recent paper titled Plaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025, both of which were also co-authored by former guests Dr. Norwitz and Dave Feldman, who we hosted in episode 109 of Boundless Body Radio!Find Dr. Soto-Mota at-TW- @AdrianSotoMotaPlaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025Keto Cholesterol study SHOCKS scientific community | LMHRs & heart disease from the Nutrition Made Simple YouTube ChannelAnalyzing the KETO-CTA Study with Dr. Gil Carvalho 813 on Boundless Body Radio!Discussing Keto-CTA with Darius Sharpe with Dave Feldman and Darius SharpeFind Boundless Body at- myboundlessbody.com Book a session with us here!

Fuel for the Sole
106 | Carb depletion theories, increasing HDL (the "good" cholesterol), and GI issues while running

Fuel for the Sole

Play Episode Listen Later May 20, 2025 46:14


It's another week of answering listener questions! In this episode, we discuss: If carb depletion before a big race has any ground  What it means if you have low HDL and what might be causing it Why you may be feeling nauseous mid-race and how to fix it Tips for avoiding all kinds of GI issues during training and racing Want to be featured on the show? Email us (written or an audio file!) at⁠ fuelforthesolepodcast@gmail.com⁠. This episode is fueled by ASICS and RNWY!Head over to⁠ ASICS.com⁠ and sign up for a OneASICS account. It's completely free and when you sign up you will receive 10% off your first purchase. You also gain access to exclusive colorways on ASICS.com, free standard shipping, special birthday month discounts and more.We've been using RNWY collagen, protein and pre workout and loving it. Head over to ⁠https://rnwy.life/⁠ and use code FEATHERS15 for 15% off your purchase. Disclaimer: This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Higher Density Living Podcast
Rewild Your Soul: The Ancient Feminine Wisdom We Forgot

Higher Density Living Podcast

Play Episode Listen Later May 20, 2025 33:35


Overview   In this profoundly evocative episode of Higher Density Living, Jason Rigby welcomes Mary Reynolds Thompson, transformational coach and author of The Way of the Wild Soul Woman. Together, they traverse the barren landscapes and lush forests of the feminine psyche—inviting listeners into a mythic journey through the five sacred archetypes: Desert Woman, Forest Woman, Ocean/River Woman, Mountain Woman, and Grassland Woman. Mary masterfully unpacks how patriarchal systems fractured women's ancient bond with the Earth—and how reconnecting with nature's rhythms heals not only personal trauma but our planet itself. From honoring the barren stillness of solitude to embracing the spiraling growth of forest paths, this episode is a luminous guide for women and men alike to reclaim lost wisdom and embodied wholeness.   Whether you feel disoriented in a hyper-masculine world or curious about the power of archetypes, this is a compass pointing home to your primal, untamed self.   Timestamps 00:00 – Invitation to the Wild: Jason introduces Mary and the core premise of rewilding soul through Earth-based archetypes. 01:18 – What is the Wild Soul Story?: Mary defines a soul narrative rooted in Earth's psyche, inspired by Thomas Berry. 03:02 – Women & Earth: Shared Wounds: Discussion on patriarchal suppression of feminine and environmental wisdom. 08:15 – Desert Woman: The first archetype of solitude, silence, and shedding cultural roles. 13:12 – Forest Woman: Entering the spiral path of mystery, gestation, and inner transformation. 19:30 – Ocean & River Woman: Surrendering to emotion and trusting the current of longing. 26:06 – Mountain Woman: Manifesting bold purpose from inner knowing, unafraid of being seen. 29:47 – Grassland Woman: Re-entering the world with gifts and medicine, navigating return and reintegration.   Quotes “We are not separate from nature—we are nature.” – Mary Reynolds Thompson “Stillness is rebellion in a culture of overdoing.” – Mary Reynolds Thompson “Your soul's longing is sacred—it's the compass back to your wild truth.” – Jason Rigby   Resources   Internal Higher Density Living Website HDL Meditation Archives Previous HDL Episode: “Earth Is Our Ancestor” External Mary Reynolds Thompson's Website Book: The Way of the Wild Soul Woman Book: Reclaiming the Wild Soul Thomas Berry's The Dream of the Earth   Call to Action   Feeling disconnected from your essence? It's time to rewild your soul. Subscribe to HDL, share this episode with someone craving reconnection, and explore Mary's meditations and writings. The Earth remembers who you are—return to her.  

earth soul invitation ancient forgot spiritual awakening divine feminine hdl feminine power rewild feminine wisdom thomas berry mountain woman mary reynolds thompson jason rigby wild soul story higher density living
Exam Room Nutrition: Nutrition Education for Health Professionals
111 | HDL = Good, LDL = Bad? It's Not That Simple.

Exam Room Nutrition: Nutrition Education for Health Professionals

Play Episode Listen Later May 14, 2025 33:14


You've probably said it a hundred times: HDL is the "good" cholesterol, LDL is the "bad" cholesterol.But what if that explanation is oversimplified—and leading patients (and providers) to miss hidden risks?In this episode, I sit down with Dr. Josh Wageman—a Clinical Lipid Specialist, PhD researcher, and author of The Home Security System and the Lipid Neighborhood—to break down why the old-school lipid model isn't enough anymore, what a standard panel won't tell you, and how you can explain heart disease risk in a way that actually sticks with patients.If you've ever felt shaky explaining lipid panels, cardiovascular risk, or how diet ties in, this episode will give you a clearer framework—and practical tools you can use immediately with your patients.Resources:Buy the Book The Home Security System and the Lipid NeighborhoodConnect with Josh Episode 38 | Love Your HeartAny Questions? Send Me a MessageSupport the showConnect with Colleen:InstagramLinkedInSign up for my FREE Newsletter - Nutrition hot-topics delivered to your inbox each week. Disclaimer: This podcast is a collection of ideas, strategies, and opinions of the author(s). Its goal is to provide useful information on each of the topics shared within. It is not intended to provide medical, health, or professional consultation or to diagnosis-specific weight or feeding challenges. The author(s) advises the reader to always consult with appropriate health, medical, and professional consultants for support for individual children and family situations. The author(s) do not take responsibility for the personal or other risks, loss, or liability incurred as a direct or indirect consequence of the application or use of information provided. All opinions stated in this podcast are my own and do not reflect the opinions of my employer.

Well-Fed Women
Navigating Hormone Shifts in Your 30s, 40s, & 50s with Dr. Taz Bhatia

Well-Fed Women

Play Episode Listen Later May 13, 2025 54:40


Your blueprint for navigating hormone shifts in your 30s, 40s, & 50s! In today's episode, integrative medicine physician Dr. Taz Bhatia talks about how to optimize hormones in your late 30s, what to do to support your liver and estrogen detoxification during perimenopause, and everything you need to know about starting hormone replacement therapy. We also answer your questions about lab work, signs of specific hormone imbalances, and unexplained midlife weight gain. This one has it all! Timestamps:[1:38] Noelle Intro[3:35] Welcome Dr. Taz [4:00] What's the latest research saying about women's health and hormones and what are you seeing actually work with your patients? [10:31] In your experience, what are the top things that women can do in their 30's to set themselves up for success in perimenopause?[14:40] Should we be looking at our numbers from testing and using that information to “optimize” them?[21:04] What's are the differences between the many hormonal shifts in our 30's?[26:47] What's a good repletion plan once we've been depleted due to stress, pregnancy or other things?[35:05] Do you think that women, as they enter perimenopause, should be regularly supporting the liver with herbs?[40:23] In perimenopause, what should I consider taking and what are the must dos? How do we know when it's time to start HRT?[42:12] Can you talk about the symptoms of low and high estrogen and progesterone? [44:35] How do you find a doctor that actually prescribes HRT? [45:25] I'm curious about when the right time is to get on HRT. Should I start it as a preventative measure or wait until I start experiencing symptoms? [46:39] What about HRT for people with the MTHFR mutation? [48:33] The change in body proportions have really played with my head. It's hard to feel healthy with an increase in midsection fat. How do I address this? [51:07] Is there any way to lower slightly elevated LDL cholesterol in perimenopause, even if HDL cholesterol is great? [51:30] Why do I feel terrible during ovulation? Episode Links:Hol+Follow Dr. Taz on InstagramThe Hormone Shift: Balance Your Body and Thrive Through Midlife and Menopause Super Woman Rx: Unlock the Secrets to Lasting Health, Your Perfect Weight, Energy, and Passion with Dr. Taz's Power Type PlansThe 21-Day Belly Fix: The Doctor-Designed Diet Plan for a Clean Gut and a Slimmer Waist Sponsors:Go to https://thisisneeded.com/  and use coupon code WELLFED for 20% off your first order.Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.Go to http://mdlogichealth.com/immuno and use coupon code WELLFED for 10% off.Go to wellminerals.us/chill and use code WELLFED to get 10% off your order.

Optimal Health Daily
2972: Lowering Cholesterol Naturally Through Diet and Exercise

Optimal Health Daily

Play Episode Listen Later May 9, 2025 12:23


Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2972: Dr. Neal Malik breaks down the cholesterol puzzle, explaining the difference between "good" and "bad" cholesterol, and why not all dietary fats, or even dietary cholesterol, are created equal. Learn the six simple lifestyle changes that can naturally improve your cholesterol profile and reduce long-term health risks. Quotes to ponder: "Cholesterol actually acts as a transporter in the body, the precious cargo in this case: fat." "Fiber is like HDL's sidekick, it helps the body get rid of that lousy or lethal LDL cholesterol." "High intensity activity in particular seems to help increase the happy or healthy HDL levels in the blood." Episode references: American Heart Association - Cholesterol: https://www.heart.org/en/health-topics/cholesterol Learn more about your ad choices. Visit megaphone.fm/adchoices

Optimal Health Daily - ARCHIVE 1 - Episodes 1-300 ONLY
2972: Lowering Cholesterol Naturally Through Diet and Exercise

Optimal Health Daily - ARCHIVE 1 - Episodes 1-300 ONLY

Play Episode Listen Later May 9, 2025 12:23


Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2972: Dr. Neal Malik breaks down the cholesterol puzzle, explaining the difference between "good" and "bad" cholesterol, and why not all dietary fats, or even dietary cholesterol, are created equal. Learn the six simple lifestyle changes that can naturally improve your cholesterol profile and reduce long-term health risks. Quotes to ponder: "Cholesterol actually acts as a transporter in the body, the precious cargo in this case: fat." "Fiber is like HDL's sidekick, it helps the body get rid of that lousy or lethal LDL cholesterol." "High intensity activity in particular seems to help increase the happy or healthy HDL levels in the blood." Episode references: American Heart Association - Cholesterol: https://www.heart.org/en/health-topics/cholesterol Learn more about your ad choices. Visit megaphone.fm/adchoices

Higher Density Living Podcast
The Spiritual Alchemy of Fatherhood: Creation, Innocence, and Evolution

Higher Density Living Podcast

Play Episode Listen Later May 8, 2025 12:22


Introduction   Welcome back to Higher Density Living! After a brief hiatus, hosts Alexander McCaig and Jason Rigby reunite in the studio, buzzing with life's latest revelations. Jason returns from a European adventure, while Alexander steps into fatherhood with the birth of his son, Gabrael. Together, they unpack the profound alchemy of parenting—blending raw spiritual awe with biological evolution. This episode, Part 1 of a two-part series, invites listeners to explore creation's edge, where innocence meets potential and exhaustion reveals divinity.   Hosts Bio Alexander McCaig: Co-host of HDL, a consciousness seeker and new father, sharing transformative insights from his journey into parenthood. Jason Rigby: Co-host, spiritual guide, and father, back from a European trip, weaving travel tales with deep reflections on the human condition.   Key Discussion Points 1. The Return and Life Updates Jason kicks off: “We're back! My gosh, it's been some time. You've really been gone—you've been busy.” Alexander: “I've been gone ‘cause I had a newborn recently—one of the most transformational experiences of my entire life.” Jason: “You were in Europe too—Napoleon, Corsica. But yeah, we're both fathers now. Kind of wow, right?”   2. Fatherhood as Creation's Mirror Alexander: “The power of creation at the human level—another human growing inside a human because two came together. It's not just physical, it's deeply spiritual.” Jason: “It's a symbolization of creation growth—innocence and potential, that's all that's there.” A renewal moment: The newborn reflects creation's essence—pure, unfiltered, and brimming with possibility.   3. Innocence and Potential in Newborns Jason: “What I love from a spiritual perspective is seeing innocence and potential—so beautiful, we forget it.” Alexander: “They're helpless, needing 100% of your attention—like tending the most delicate crops.” Jason: “They're not desensitized like us—they see the world fresh, and we can't limit that.”   4. The Responsibility of Self-Awareness Alexander: “You need self-control and self-awareness to not impress your stifled energy onto the child.” Jason: “Everything you bring to their care opens their potential—or stifles it. There's two options.” Alexander: “You'd want the maximum and the best—hoping they take your best and step above you. That's evolution's point.”   5. Biological Evolution in Parents Jason: “Parents undergo shocking transformations—gray matter increases, prefrontal cortex and hypothalamus grow for bonding.” Alexander: “Oxytocin's through the roof—your senses max out, supercharging your brain.” Jason: “Evolution doesn't stop; having a kid accelerates it for both parent and child.”   6. Sanctification Through Chaos Jason: “Sleepless nights and constant care—it's sanctifying, a space for divine presence.” Alexander: “Try this: Use the newborn as a candle—gaze into their eyes silently. You'll be shocked how long they hold your attention.” Jason: “It's pure connection—a meditation.”   7. The Energy of Naming (Gabrael's Story) Alexander explains naming his son Gabrael Rowin: “Energy in names matters—spelling and meaning align with creation's patterns.” Why “Gabrael” (AEL spelling): “An older, primordial form meaning ‘might of creation,' synced with birth timing and Chaldean numerology.” Rowan: “‘One who lives in righteousness'—congruent energy for his potential.” Jason: “I love that—it's not just a name, it's intentional energy.”   8. Awe and Exhaustion as Spiritual Gifts Jason: “Why do we feel awe in exhaustion after birth?” Alexander: “It's creation reminding you of true purpose—a visceral truth you've ignored, demanding your attention.” Alexander: “You could feel this awe every moment if you paid attention, but the baby forces it. Look at the raw power and beauty.”   Memorable Quotes “The power of creation at the human level—it's a renewal.” – Alexander “Innocence and potential—that's all that's there in a newborn.” – Jason “Your brain evolves as much as the child's—evolution doesn't stop.” – Jason “Creation wakes you up: Look at the raw power and beauty of this.” – Alexander   Resources Mentioned HDL Podcast Archives: Explore all episodes at higherdensityliving.com Coming Soon: Part 2 of this fatherhood series—stay tuned!   Call to Action Subscribe to Higher Density Living for Part 2 and more consciousness explorations. Share your thoughts: How has creation touched your life? Comment below! Visit higherdensityliving.com to browse past episodes and awaken your potential.   Closing Thoughts   Jason and Alexander close Part 1 with excitement for a deeper dive in Part 2, leaving listeners with a powerful reflection: Fatherhood isn't just raising a child—it's a spiritual and evolutionary catalyst. From Gabrael's energy to the awe of exhaustion, this episode beckons you to look within and embrace creation's edge.   Connect with HDL:    Facebook: https://www.facebook.com/highdensityliving Instagram: https://www.instagram.com/hdlspiritualpodcast/ YouTube: https://www.youtube.com/@HigherDensityLiving TikTok: https://www.tiktok.com/@higherdensityliving   Subscribe: Join Alexander and Jason for more journeys into the unseen.  

Comiendo con María (Nutrición)
2027. Caso real. Vino por el colesterol, pero ese no era el problema.

Comiendo con María (Nutrición)

Play Episode Listen Later May 5, 2025 29:17


Presentación del caso – Motivo de consulta y contexto personalUna mujer de 42 años acude a consulta preocupada por su colesterol alto. Viene derivada tras una analítica en la que han detectado hipercolesterolemia leve, y ella cree que puede deberse a los “picoteos” que tiene por la tarde, que últimamente han ido a más. También quería trabajar su relación con la comida. Decía que por las tardes tenía una ansiedad desbordante, que se comía lo que fuera, sin hambre real. Se culpaba constantemente, se sentía fuera de control y con una enorme frustración porque siempre había sido muy consciente de su alimentación. Me cuenta que no entiende por qué le pasa, porque siempre ha comido bien, lleva una alimentación bastante equilibrada, y aunque no hace mucho deporte, se mantiene activa.Trabaja como administrativa en una empresa de seguros. Tiene dos hijos adolescentes, poco tiempo para ella y la sensación constante de que va a mil. Me explica que a media tarde llega a casa, cansada y con ansiedad, y que ahí es cuando arrasa con lo que pilla.Dice que duerme mal desde hace unos meses, que se despierta de madrugada sin motivo, que se nota más irritable y que últimamente le cuesta más concentrarse en el trabajo. También ha notado que su cuerpo ha cambiado: “Estoy más hinchada, me noto más barriga, aunque coma igual”, comenta.Le pregunto por su menstruación, y me dice algo muy típico: “Siempre la he tenido irregular, así que no sé… a veces me viene cada 40 días, a veces se me salta un mes entero, pero esto me pasa desde siempre”.Por eso, ni se plantea que lo que le está pasando pueda tener que ver con la menopausia.Desarrollo del caso – Qué vimos en consultaRevisamos su analítica.Efectivamente, hay una hipercolesterolemia, pero también aparecen otros datos que me llaman la atención:Déficit de vitamina D,Ferritina un poco baja,Magnesio en el límite inferior,Glucosa en ayunas un poco elevada,Y un perfil lipídico alterado, con un LDL elevado y HDL algo bajo.Con todo esto, y teniendo en cuenta la edad, los síntomas, el insomnio, el cambio en la distribución de la grasa corporal, la irritabilidad, la niebla mental y el déficit de vitamina D, empiezo a pensar en una posible perimenopausia.Se lo planteo, y se sorprende. “¿Tan pronto? Si todavía tengo la regla…”, me dice. Le explico que esta etapa puede comenzar años antes de la menopausia como tal, y que lo que le está pasando encaja perfectamente con ese perfil.Intervención – Cómo lo trabajamosEn consulta decidimos abordar el caso desde varios frentes:Alimentación:Adaptamos su pauta para favorecer el control del colesterol, pero también para mejorar su saciedad y estabilidad energética por la tarde.Añadimos más proteína en desayuno y comida.Trabajamos el equilibrio en las meriendas para prevenir los atracones y redujimos los azúcares simples.Incorporamos alimentos ricos en fitoestrógenos y omega 3.Relación con la comida:Exploramos el papel del picoteo como vía de escape ante el cansancio y la frustración.Introducimos estrategias de autocuidado emocional que no pasaran por la comida.Le ayudé a dejar de culpabilizarse y a comprender que no era falta de voluntad: era su cuerpo atravesando una transición.Ejercicio físico:Le recomendé ejercicios de fuerza dos veces por semana, empezando por rutinas sencillas en casa.Incluimos también caminatas diarias para mejorar su metabolismo, descanso y ánimo.Sueño y descanso:Ajustes de hábitos antes de dormir.Rutinas de relajación y revisión del entorno del sueño.Consideramos junto con su médico la suplementación con melatonina.Suplementación:Vitamina D, por el déficit evidente.Magnesio por sus beneficios en esta etapa (descanso, estado de ánimo, regulación hormonal).Omega 3 por perfil lipídico y efecto antiinflamatorio.Evolución y resultadosA las 4 semanas, ya notaba cambios:El picoteo por la tarde se redujo drásticamente.Dormía mejor.Tenía más energía durante el día.Se sentía menos culpable y más conectada con su cuerpo.Y lo más importante: empezó a reconciliarse con esta etapa, entendiendo que no era una enfermedad ni una derrota, sino un proceso natural que, con el enfoque adecuado, podía atravesar con bienestar.A los 3 meses, la analítica mejoró notablemente:Bajó el colesterol total y el LDL.Subió el HDL.Vitamina D dentro de rango.Y, además, había recuperado el control sobre su alimentación sin necesidad de restringir ni contar calorías.ConclusiónMuchas mujeres llegan a consulta preocupadas por su colesterol, su peso o su ansiedad por la comida, sin saber que lo que de verdad está ocurriendo es que han entrado en la perimenopausia.Y como no se lo han explicado, lo viven con culpa, confusión y soledad.Este caso nos recuerda la importancia de mirar más allá del síntoma y de acompañar esta etapa desde la comprensión, el respeto al cuerpo y un enfoque integral.Porque cuando entendemos lo que nos pasa, es mucho más fácil cuidarnos.Conviértete en un seguidor de este podcast: https://www.spreaker.com/podcast/comiendo-con-maria-nutricion--2497272/support.

Doctor Warrick
EP384: Will Your HDL Save You?

Doctor Warrick

Play Episode Listen Later May 3, 2025 12:10


Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the complexities of HDL cholesterol, often referred to as "good" cholesterol. He explains the roles of different types of cholesterol, specifically Apo B proteins associated with LDL cholesterol, which contribute to plaque formation and cardiovascular risk. While HDL is involved in transporting cholesterol back to the liver, its protective role is more complicated than previously thought.

BetterHealthGuy Blogcasts
Episode #216: Metabolic Vulnerability Index with Dr. Darren Schmidt, DC

BetterHealthGuy Blogcasts

Play Episode Listen Later Apr 28, 2025 103:23


Why You Should Listen:  In this episode, you will learn about Metabolic Vulnerability Index (MVX) as an indicator of mortality and longevity. About My Guest: My guest for this episode is Dr. Darren Schmidt.  Darren Schmidt, DC is the Founder of The Nutritional Healing Center of Ann Arbor which is the largest non-insurance nutrition clinic in the country.  His purpose is to bankrupt pharmaceutical companies by teaching doctors how to improve health rather than treat symptoms.  He uses new and old clinical discoveries to solve complex chronic illness with only diet and supplements.  He uses MVX Plus, the best lab test to measure longevity and health, and it also directs the treatment plan. Key Takeaways: What is MVX? What are the 6 factors and 3 indices that are explored with MVX? How might MVX be a better metric for mortality than many conventionally-used metrics today? Can MVX be extrapolated to be used as a measure of health and longevity? What is GlycA?  What drives it? What tools can be used to lower GlycA? What is the connection between GlycA and hypercoagulation? Why is eGFR and kidney health often used on the context of predicting mortality? What is small HDL particle number?  How can it be optimized? What is the Inflammation Vulnerability Index? What is citrate?  What tools can be used to lower it when elevated? What is the connection between citrate and mitochondrial function? What is lactic acidosis? What is learned from looking at valine, leucine, and isoleucine? What steps may be taken if they are high?  If they are low? What is the Metabolic Malnutrition Index? When might a keto diet be appropriate? What does the Metabolic Vulnerability Index tell us? Is MVX impacted by genetics or epigenetics? What is the 7 Step Blueprint to Optimal Health? How do the 7 steps overlap with the 6 MVX factors? Connect With My Guest:  TheNutritionalHealingCenter.com Related Resources: To see the resources in the Show Notes, visit https://BetterHealthGuy.com/Episode216. Interview Date: April 21, 2025 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode216. Additional Information: To learn more, visit https://BetterHealthGuy.com. Follow Me on Social Media: Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy Disclaimer:  The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority. 

Fat Science
Blood Fats: The Good, the Bad & the Ugly

Fat Science

Play Episode Listen Later Apr 21, 2025 37:15


This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright dive into the world of blood fats—unpacking what cholesterol numbers really mean for your health. They break down HDL (the “good” cholesterol), LDL (the “bad” cholesterol), triglycerides, and spotlight the often-overlooked lipoprotein(a), a genetic risk marker with significant consequences for heart health. The team dispels myths about fats in our diet, covers the impact of lifestyle and genetics, and explores how advanced testing can reveal hidden risks. You'll come away understanding which fats matter most, why particle size counts, and what actions can help manage your numbers and protect your heart.Key Takeaways:Blood fats, specifically HDL, LDL, and triglycerides, are critical indicators of cardiovascular risk. Advanced testing can identify dangerous subtypes and genetic markers like lipoprotein(a) that standard panels miss.HDL has benefits, but high numbers don't cancel out high LDL; LDL particle size and count are crucial—small, dense particles are more harmful.Lipoprotein(a) is a major genetic risk factor for heart disease and stroke that isn't modifiable by diet or exercise; new treatments are in development.Plant-based monounsaturated fats (like olive oil and avocados), resistant starches, and soluble fiber offer metabolic and heart-health benefits, but even perfect diets may not lower genetic cholesterol risks.Lifestyle factors—exercise, avoiding smoking, quality sleep, and managing conditions like diabetes—are critical for reducing cardiovascular risk, especially if you have inherited risk markers.Heart health isn't just about body size—“looking healthy” doesn't guarantee healthy arteries; everyone should know their numbers and consider advanced heart scans as needed.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Mind & Matter
Ketogenic Diet: Cholesterol, Plaque & Heart Heart | Matthew Budoff | 223

Mind & Matter

Play Episode Listen Later Apr 19, 2025 58:44


Send us a textShort Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher.About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Matthew Budoff discusses cholesterol, heart disease, and his study on the ketogenic diet's impact on lean, metabolically healthy individuals with high LDL cholesterol. He explains LDL, HDL, and triglycerides, debunking myths about their direct link to heart disease, and emphasizes the importance of coronary calcium scans to assess plaque buildup. Budoff also covers statins, dietary cholesterol, and personalized heart health strategies.Key Takeaways:LDL cholesterol is not a definitive predictor of heart disease; plaque buildup, assessed via coronary calcium scans, is a better indicator.Lean metabolically healthy people on a ketogenic diet may have high LDL without increased plaque progression after one year.Coronary calcium scans, costing ~$100, are recommended for men around age 40 and women around 45-50 to evaluate heart disease risk.Statins effectively lower LDL and can reverse soft plaque, but may be overprescribed for those without plaque buildup.Dietary cholesterol has minimal impact on blood cholesterol, as the liver produces ~85% of it.Ketogenic diet can aid weight loss & diabetes control but may cause high LDL in some lean individuals, known as lean mass hyper-responders.Plaque progression depends more on existing plaque than LDL levels in metabolically healthy ketogenic diet followers.Heart health varies widely due to genetics and other unknown factors, underscoring the need for personalized assessments.Related episode:M&M #158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'AgoSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Dietitian Dad
Ep 72: The “Lipid” Episode

Dietitian Dad

Play Episode Listen Later Apr 14, 2025 17:58


Are you aware of your lipid profile? You need to be..and Dietitian Dad (Mike) explains why in this informative episode. He looks at the latest studies on how to raise HDL (good cholesterol) levels as well as other recent studies around fat/cholesterol. Plus: a new restaurant just opened in his area and this set off a nerve..get ready for a rant! Enjoy and don't forget to leave a review!!

Barbell Shrugged
Physiology Friday: [Cholesterol] How to Read Bloodwork for Lipids, Triglycerides, and Fatty Acids w/ Anders Varner, Doug Larson, and Dan Garner Barbell Shrugged

Barbell Shrugged

Play Episode Listen Later Apr 11, 2025 44:22


In today's episode of Barbell Shrugged you will learn: What are lipids What is cholesterol The difference between HDL and LDL cholesterol Why there is no such thing as “good” or “bad” cholesterol What are the bloodwork numbers for optimal cholesterol What is the perfect ratio of HDL and LDL Ratios for Triglycerides to HDL for optimal health Mechanisms for regulating cholesterol in the liver Why saturated fats are not bad and how your body uses them Cholesterols role in testosterone production To learn more, please go to https://rapidhealthoptimization.com Connect with our guests: Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram Dan Garner on Instagram

Dr. Chapa’s Clinical Pearls.
PCOS, Mood, and Metformin: New Data on MetSyn.

Dr. Chapa’s Clinical Pearls.

Play Episode Listen Later Mar 28, 2025 33:08


Metabolic syndrome (MetSyn) is a cluster of conditions, such as increase in waist circumference, dyslipidemia (elevated triglyceride levels and reduced HDL), increased blood pressure, and increased fasting blood sugar levels that is related to insulin resistance, diabetes, and elevated risk of cardiovascular disease. Women with PCOS have a significantly higher prevalence of metabolic syndrome (MetS) compared to the general population, with studies indicating a prevalence of around 43-47% in PCOS women. PLUS, there is a high prevalence of moderate to severe depressive symptoms and depression in adults and adolescents with PCOS; therefore, screening for depression in all adults and adolescents with PCOS is encouraged. In this episode, we will review a new publication for the J Clinical Endo & Metabolism discussing this combination (PCOS and depression/anxiety) and the MetSyn, and we will review the EXPANDED indications for metformin for metabolic syndrome prevention/treatment according to the 2023 PCOS updated guidance.

Well-Fed Women
How to Manage Hormone Changes, Weight Gain, and Metabolic Function in Midlife with Dr. Mariza Snyder

Well-Fed Women

Play Episode Listen Later Mar 11, 2025 69:17


You hit 38, and all of the sudden the same stuff isn't working like it used to! So, what's going on? Dr. Mariza tackles the science behind weight changes in midlife, and how to build metabolic resilience and insulin sensitivity as you age. We also talk through lab work and how to make changes based on your blood work and symptoms. Perimenopause doesn't have to suck, and small shifts can completely change your life in the decades to come!Timestamps:[3:12] Interview with Dr. Mariza[3:26] What was the moment you knew you were in perimenopause? [7:03] What is happening to our hormones mid-life?[16:20] Where should women realistically start?[19:33] Are you ok with getting baseline markers in a blood test or is there a better way? [30:48] Is it normal for testosterone to be low and decline as women are in their upper 30s?[34:07] What is metabolic flexibility and how do you know if you actually have it?[37:03] Is there really a thing as being “in balance” with your hormones?[39:02] I'm curious about when the right time is to get on HRT - should I start it as a preventative measure or wait until I experience symptoms?[40:44] What should you test or do when you're doing everything right and still gaining weight? [47:16] How does blood glucose drive a change in fat storage and how can we improve that? [53:14] I am 41 and the same weight as last year but my middle is different - no change in diet or exercise, in fact I'm more disciplined than I've ever been. Help! [57:06] How do we combat burnout on all things “life” when there's no choice but to keep going?[1:04:34] Are you more sensitive to cortisol in mid-life and perimenopause and, if so, how?Episode Links:Visit Dr. Mariza's WebsitePerimenopause Survival GuideLab tests to run:Complete blood countComprehensive metabolic panel (should have fasting glucose included)Vitamin D3 – Needs to be 50+Fasting insulin - 5 or belowFasting blood glucose - 85 ml or lowerHemoglobin A1CC-Reactive Protein (CRP): Under 1Lipid panel: HDL above 50Apo B Test - under 85Uric acidHormonesCortisolFull testosterone panelFull thyroid panel Estradiol Progesterone Sponsors:Go to wellminerals.us/creatine and use code WELLFED to get 10% off your order. Launching April 1st!Go to http://mdlogichealth.com/mc  and use coupon code WELLFED for 10% off.Go to https://thisisneeded.com/  and use coupon code WELLFED for 20% off your first order.Go to boncharge.com/WELLFED and use coupon code WELLFED to save 15% off any order.

Behind The Knife: The Surgery Podcast
Journal Review in Bariatric Surgery: Pediatric Bariatric Surgery

Behind The Knife: The Surgery Podcast

Play Episode Listen Later Feb 24, 2025 34:34


Join the Behind the Knife Bariatric Surgery Team as they kick off 2025 with a crucial discussion on pediatric and adolescent bariatric surgery. Drs. Matt Martin, Adrian Dan and Katherine Cironi delve into the latest ASMBS guidelines, comparing long-term outcomes of gastric bypass and sleeve gastrectomy in adolescents versus adults. They explore key comorbidities, including type 2 diabetes, hypertension, and orthopedic issues, and emphasize the importance of early intervention. This episode also tackles the complex ethical considerations surrounding surgery in this vulnerable population, including consent, multidisciplinary care, and the evolving role of medical therapies like GLP-1 agonists. Show Hosts: - Matthew Martin - Adrian Dan - Katherine Cironi Learning Objectives:  ·  Identify the current ASMBS guidelines for pediatric and adolescent bariatric surgery, including BMI thresholds and associated comorbidities.  ·  Describe common comorbidities seen in the pediatric population eligible for bariatric surgery, such as type 2 diabetes, hypertension, and orthopedic issues.  ·  Compare and contrast long-term outcomes of bariatric surgery (gastric bypass and sleeve gastrectomy) in adolescents and adults, including remission rates of comorbidities and reoperation rates.  ·  Discuss the importance of a multidisciplinary approach, including psychological and ethical considerations, when evaluating adolescent patients for bariatric surgery.  ·  Explain the ethical framework used in evaluating adolescents for bariatric surgery, including consent/assent, parental involvement, and addressing potential coercion.  ·  Recognize the evolving role of medical management (e.g., GLP-1 agonists) in conjunction with or as an alternative to bariatric surgery in adolescents. Article #1: Inge 2019 – Five-year outcomes of gastric bypass in adolescents as compared with adults https://pubmed.ncbi.nlm.nih.gov/31461610/ - The cumulative effect of sustained severe obesity (BMI >35) from adolescence into adulthood increases the likelihood of diabetes, hypertension, respiratory conditions, kidney dysfunction, walking limitations, and venous edema in legs/feet (when compared to adults that did not report severe obesity in adolescence) - American Society for Metabolic and Bariatric Surgery (ASMBS) guidelines for adolescents who should be considered for bariatric surgery: BMI is ≥35 with a co-morbidity or if they have a BMI ≥40 (class 3 obesity, 140% of the 95th percentile) - This article utilizes the Teen-Longitudinal Assessment of Bariatric Surgery (TEENS LAB) and LABS (adults) databases to evaluate the outcomes of adolescents vs. adults who underwent bariatric surgery Roux-en-Y gastric bypass (2006-2009) - 161 adolescents (13-19 at the time of surgery) with severe obesity (BMI>35) vs 396 adults (25-50 years old at the time of surgery) who have remained obese (BMI>30) since adolescence  - Both groups had the gastric bypass procedure as their primary bariatric operation  - Both groups had unadjusted similar demographics, however, BMI was higher in adolescence (54) when compared to adults (51)  - Results were analyzed using linear mixed and Poisson mixed models to analyze weight and coexisting conditions - After surgery, adolescents were significantly more likely than adults to have remission of type 2 diabetes and hypertension - Increased likelihood of remission of diabetes due to the shorter duration of diabetes, lower baseline glycated Hgb, less use of medications, and increased baseline C-peptide levels  - Increased vascular stiffness in adults along with a longer duration of hypertension make the cessation of hypertension less responsive with surgery in adults  - No significant difference in percent weight changes between adolescents and adults 5 years after surgery  - Both adults and adolescent groups had decreased rates of hypertriglyceridemia and low HDL levels, albeit not significantly different when comparing the two groups  - Of note, the rate of abdominal reoperations was significantly higher among adolescents (20%) than among adults (16%) with cholecystectomy representing nearly half the procedures in both groups - Limitations - At baseline, adults had a high prevalence of both diabetes and hypertension - only 14% of adolescents had diabetes vs 31% of adults  - Only 30% of adolescents had hypertension vs 61% of adults  Article #2: Ryder 2024 – Ten-year outcomes after bariatric surgery in adolescents  https://pubmed.ncbi.nlm.nih.gov/39476348/ - The goal is to discuss the long-term durability of weight loss and remission of coexisting conditions in adolescents after bariatric surgery  - This article utilizes the Teen-Longitudinal Assessment of Bariatric Surgery (TEENS LABS) database to evaluate the 10-year outcomes in adolescents who underwent gastric bypass or sleeve gastrectomy  - 260 adolescents with an average age of 17 years old at the time of surgery (ages ranged from 13-19 years old) - 161 adolescents underwent gastric bypass, 99 adolescents underwent sleeve gastrectomy  - Results were analyzed using propensity score-adjusted linear and generalized mixed models  - At 10 years, the average BMI had decreased significantly with both groups experiencing about a 20% change in BMI on average - To assess comorbidities, both groups were analyzed together -  55% of patients who had DM2 at baseline, were in remission at 10 years - 57% of patients who had HTN at baseline, were in remission at 10 years -  54% of patients who had dyslipidemia at baseline, were in remission at 10 years - Limitations  - Neither of these studies compare surgery to medical management. GLP-1s have shown promise for weight loss management but we need more data in terms of long-term outcomes in co-morbidities like diabetes, hypertension, dyslipidemia  - Highlighted Outcomes  - Metabolic bariatric surgery is quite effective in the adolescent population  - Adolescents tend to have weight loss that is similar to that of adults and improved resolution of comorbid conditions (DM2, HTN, dyslipidemia) Article #3: Moore 2020 – Development and application of an ethical framework for pediatric metabolic and bariatric surgery evaluation https://pubmed.ncbi.nlm.nih.gov/33191162/ - The purpose of this paper is to describe the ethical framework that supports the use of metabolic & bariatric surgery (MBS) on the principle of justice, and how providers can conduct a thorough evaluation of patients presenting for these surgeries - Highlights adolescents with intellectual and developmental disabilities (IDD) and preadolescent children who pose more ethical questions before considering surgery  - This article utilizes the bariatric surgery center at one children's hospital and the institution's ethics consult service to develop an ethical framework to evaluate pediatric patients seeking bariatric surgery – using the national ASMBS guidelines  - This ethical framework utilized 4 central ethical questions 1.     Should any patients be automatically excluded from evaluation for MBS? 2.     How should it be determined that the benefits of MBS outweigh the risks? 3.     How do we ensure the patient fully understands and is capable of cooperating with the surgery and follow-up care? 4.     How do we make sure the decision to have surgery is truly voluntary, and not coerced by family or others? - Results: this ethical framework was discussed in depth in two case studies  - Overview of framework: an ethical question would arise from the bariatric team they would review & apply the ethical framework. The question is either resolved by the bariatric team OR ethics consult, continue pre-operative workup vs no surgery - Case 1: 17M (BMI 42) with a history of autism spectrum disorder, pre-DM, depression with behavior challenges, HTN, dyslipidemia. Testing at school demonstrates intellectual functioning at a fourth-grade level. Pt lives with mom and 11-year-old sister. Mom endorses food insecurity (on supplemental nutrition assistance benefits) and struggles with her son's large intake of food.  1.     Co-morbidities should not be exclusionary, but pt should undergo a comprehensive psychosocial evaluation with attention to family dynamics and support and the patient's decision-making capacity  2.     Discuss benefits vs risks. Benefits – decreased progression of DM2, HTN, hyperlipidemia, cardiometabolic dx. Risks – gastric leak, infection, bleeding, dumping syndrome, etc.  3.     Can assess decision-making capacity with the surgical team or if need be other teams. In this case, the pt had limited decision-making capacity  - His level of understanding remained stable during the pre-op visits, and he gave assent to surgery - The mom identified a second source of support (extended family) - The team talked to both the patient and mother alone and then, together, found that the patient developed an independent desire for surgery, and thus moved forward.  - Case 2: 8F (BMI 50) with a history of mod OSA, L slipped capital femoral epiphysis s/p surgical stabilization (6 mos prior). The patient is neurotypical & excels in school, and lives with mom & dad. Referred by mom & dad (mom with a recent history of sleeve gastrectomy).  1.     An 8-year-old should not be discriminated against based solely on age, but the patient should be offered more conservative/less invasive options before OR.  a.     In this case, the family had not yet been offered these nonsurgical approaches (structured weight management program, physical support, dietician) 2.     Discuss benefits vs risks. Benefits – preventing progression of hip disease, improvement of OSA, decreased risk of cardiometabolic dx. Risks – anatomic/infectious/nutrition risks  3.     Decision-making capacity was assessed. Found that the parents were more advocating for the surgery saying she has a poor quality of life physically and socially. When the patient was separated from her parents, she said she could lose weight if she had healthier foods at home and someone to exercise with. The patient had decision-making capacity & did not assent to surgery.  4.     When the ethics team interviewed the patient and parents, the parents had a strong preference toward surgery vs patient was scared of surgery and wanted to try other approaches first  a.      Decided that the child's dissent outweighed the medical necessity for surgery and that there were conservative treatment options still available to try  - Highlighted Outcomes  - ASMBS guidelines give us good direction on who qualifies for surgery and emphasize an interdisciplinary approach to decision-making. The decision to pursue surgery should always weigh the benefits and risks and should be made collaboratively with the patient, family, and care team ***SPECIALTY TEAM APPLICATION LINK: https://docs.google.com/forms/d/e/1FAIpQLSdX2a_zsiyaz-NwxKuUUa5cUFolWhOw3945ZRFoRcJR1wjZ4w/viewform?usp=sharing Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.

The Peter Attia Drive
#334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D.

The Peter Attia Drive

Play Episode Listen Later Feb 3, 2025 137:37


View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Tom Dayspring is a world-renowned expert in clinical lipidology and a previous guest on The Drive. In this episode, Tom explores the foundations of atherosclerosis and why atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide for both men and women. He examines how the disease develops from a pathological perspective and discusses key risk factors, including often-overlooked contributors such as insulin resistance and chronic kidney disease. He breaks down the complexities of cholesterol and lipoproteins—including LDL, VLDL, IDL, and HDL—with an in-depth discussion on the critical role of apolipoprotein B (apoB) in the development of atherosclerosis. Additionally, he covers the importance of testing various biomarkers, the impact of nutrition on lipid levels, and the vital role of cholesterol in brain health, including how cholesterol is synthesized and managed in the brain, how it differs from cholesterol regulation in the rest of the body, and how pharmacological interventions can influence brain cholesterol metabolism. We discuss: Defining atherosclerotic cardiovascular disease (ASCVD): development, risks, and physiological impact [2:45]; The pathogenesis of ASCVD: the silent development over decades, and the importance of early detection for prevention of adverse outcomes [10:45]; Risk factors versus risk markers for ASCVD, and how insulin resistance and chronic kidney disease contribute to atherosclerosis [17:30]; How hyperinsulinemia elevates cardiovascular risk [24:00]; How apoB-containing lipoproteins contribute to atherosclerosis, and why measuring apoB is a superior indicator of cardiovascular risk compared to LDL cholesterol [29:45]; The challenges of detecting early-stage atherosclerosis before calcification appears [46:15]; Lp(a): structure, genetic basis, and significant risks associated with elevated Lp(a) [55:30]; How aging and lifestyle factors contribute to rising apoB and LDL cholesterol levels, and the lifestyle changes that can lower it [59:45]; How elevated triglycerides, driven by insulin resistance, increase apoB particle concentration and promote atherosclerosis [1:08:00]; How LDL particle size, remnant lipoproteins, Lp(a), and non-HDL cholesterol contribute to cardiovascular risk beyond apoB levels [1:21:45]; The limitations of using HDL cholesterol as a marker for heart health [1:29:00]; The critical role of cholesterol in brain function and how the brain manages its cholesterol supply [1:36:30]; The impact of ApoE genotype on brain health and Alzheimer's disease risk [1:46:00]; How the brain manages cholesterol through specialized pathways, and biomarkers to track cholesterol health of the brain [1:50:30]; How statins might affect brain cholesterol synthesis and cognitive function, and alternative lipid-lowering strategies for high-risk individuals [1:57:30]; Exciting advancements in therapeutics, diagnostics, and biomarkers coming in the next few years [2:09:30]; Recent consensus statements on apoB and Lp(a) from the National Lipid Association (NLA) [2:12:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube