Podcasts about tgab

You've got to listen to this episode, I'm breaking down everything you didn't know you needed to know about Hashimoto's, hypothyroidism, and those mysterious antibody labs called TPO and TGAb. If you've ever found yourself confused about the difference between Hashimoto's and plain-old hypothyroidism, or if you've heard the words “thyroid peroxidase” and “thyroglobulin antibodies” and immediately tuned out, this one is for you. I'm digging deep into what these antibodies really mean, why having just one out of range is actually a huge deal, and yes, why your thyroid could already be under attack even if you feel fine right now. Knowledge is power, and I'm giving you the tools to become your own patient advocate. But let's not stop at the science, this episode is also packed with my best strategies for putting Hashimoto's into remission, how your lifestyle can make or break your thyroid health, and exactly what NOT to ignore if you don't want to end up in that dreaded autoimmune spiral of fatigue, weight gain, and brain fog. You'll get the inside scoop on what can kick your antibodies into high gear, my favorite supplement hacks for high antibodies and why you should always demand a full antibody panel—no more “just checking TPO.” Jump in and learn why knowing you TPO and TGAb antibodies are so important. Podcast Episode Mentioned: Episode 312: Alternative to LDN for Weight Loss, Inflammation and Lower Antibodies; Black Cumin Seed To the Rescue WHAT DO MY LABS MEAN?! Try the ultimate tool to Decode Your Labs: Understand your thyroid, hormones, and blood sugar numbers to transform your health https://dramie.com/labs/ We prescribe to all 50 states!  When you're ready to FINALLY get the help you deserve… Book a free application call: https://dramie.com/book-a-call/ Shop ALL of Dr. Amie's Fixxr® Supplements: https://betterlifedoctor.com/ EARN CE Credits: "Nurses, hold-on  – here comes the exciting part: you can earn nursing CE credits by listening to our podcasts! That's right—RNegade has teamed up with podcast hosts like me who are delivering amazing content that doesn't limit you to “thinking outside-the box,” it challenges you to BLOW-UP the box by learning from innovators, pioneers, and RENEGADES in the field of health and medicine WHILE EARNING YOUR CEs!” https://rnegade.thinkific.com/?ref=4d98d0 RATE, REVIEW AND FOLLOW ON APPLE PODCASTS If you made it this far I'm impressed! That means you really love the show and I love you for that!  So I'm going to ask you for a favor. Would you please leave a quick review or even 5⭐️. I DO read them and can't tell you how much I appreciate it! Thank you in advance!❤️  Just click here it's quick and easy : https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263,  Ok ONE MORE favor…would you please subscribe and follow the show? This is a win-win! It tells the podcast powers that be that you like The Thyroid Fixer Podcast AND it lets you catch all the new episodes that come out every week. Follow with this link: https://podcasts.apple.com/us/podcast/the-thyroid-fixer/id1529800263 and never miss out on a moment of the journey! CONNECT WITH ME ON SOCIAL MEDIA: Want to get your labs reviewed and your questions answered LIVE by me? Join my exclusive Facebook group, Just Fix Your Thyroid – a supportive and empowering community designed to give you the tools, guidance, and HOPE you need on your thyroid and hormone journey.

This week on ReInvent Healthcare, I go over the biggest mistakes that doctors make when they test the thyroid. I also go over other types of tests that can be done in order to get to the root cause of clients' dysfunctions. IN THIS EPISODE:Reliance on TSH as the Sole IndicatorDoctors often rely solely on testing Thyroid Stimulating Hormone (TSH) levels to diagnose thyroid dysfunction. However, TSH levels might fall within the medically accepted "normal" range, even when a patient exhibits clear symptoms of thyroid dysfunction like dry skin, constipation, high cholesterol, depression, exhaustion, and weight issues. This over-reliance on TSH can lead to misdiagnosis or the dismissal of thyroid-related problems. Incomplete Testing and Ignoring SymptomsNot considering a comprehensive thyroid panel. While TSH is important, it should be complemented with tests for total T4, free T4, and free T3 levels. Additionally, antibodies such as thyroid peroxidase (TPO) and antithyroid globulin (TgAB) should be tested to identify autoimmune thyroid conditions. Doctors often ignore a patient's symptoms when conventional tests come back within the "normal" range, rather than considering whether the tests themselves might be inadequate or if other underlying issues are present.Neglecting Receptor Function and Root CausesDoctors frequently overlook the importance of receptors that allow thyroid hormones to enter cells and take action. Factors like high homocysteine levels, low vitamin A, stress-induced cortisol imbalances, and toxic exposures can disrupt receptor function and the effectiveness of thyroid hormones. Rather than addressing these root causes, patients are often prescribed medications for individual symptoms without considering the thyroid's underlying dysfunction.References:Get our FREE Guide to Taking a Detailed Health History that gets you to root causes.Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training. Check out other episodes on Thyroid here. Here's the free guide for you to help Optimize Thyroid Function.

Welcome to this week's episode of Thyroid Strong where I give you a roadmap of what Hashimoto's remission looks like from my own journey and the collaborative approach of my doctor. Listen in to find sound bites you can incorporate into your lifestyle. Key Takeaways Going into Hashimoto's remission is possible. First, find a great doctor that will work with you in creating a hierarchical framework of what to treat first instead of treating everything simultaneously. Second, change your diet, change your sleep, change your workout to a Thyroid Strong style of working out and then address the root causes that can trigger your autoimmune condition. How Do You Know When You're in Hashimoto's Remission? Of women with Hashimoto's, about 20% can go into remission. Those that go into remission have minimal destruction to the thyroid gland and exhibit their thyroid hormones within optimal range on a blood draw, no presence of thyroid antibodies specifically TGAB and TPO, and no presence of Hashimoto's symptoms. Three Changes to Make On Your Journey to Hashimoto's Remission First, change your diet. Start eliminating gluten, dairy, and alcohol. Second, change your sleep pattern. Instead of going to bed at the same time everyday, start waking up at the same time everyday and getting into the habit of a new circadian rhythm. Lastly, address the root causes of your Hashimoto's and adjust your lifestyle further including your workout. In This Episode Destruction of the thyroid gland [1:34] Three components to going into remission with Hashimoto's [1:52] First changes I made when first getting diagnosed with Hashimoto's [4:34] Address the root cause of my Hashimoto's [7:48] How to work out without burning out with Hashimoto's [11:08] Quotes “So I was one of those 20% of women who went into remission. One of the aspects was catching the diagnosis early and taking the steps to make the changes.” [4:10] “Prioritize protein 30 grams minimum to stimulate muscle protein synthesis, aka muscle growth and not only prioritize every single meal, but especially the first meal.” [9:20] “One of the things that's really important is working with a great, great doctor, for a collaborative approach to addressing some of the root causes of your Hashimotos in addition to managing your medication.” [12:24] DISCLAIMER THIS PODCAST/WEBSITE/COACHING SERVICE DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to text, graphics, images, and other material contained, are for informational purposes only. NO material on this show/website/coaching practice/or special guests are intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of YOUR physician or another qualified health provider with any questions you may have regarding medical treatment. Never delay seeking medical advice because of something you read/hear/see on our show/website/or coaching practice. Listen to the episode on https://podcasts.apple.com/us/podcast/thyroid-strong/id1425627401 (Apple Podcasts), https://open.spotify.com/show/1EkTBDKRscaAoZ0Ixwa8nY (Spotify), https://www.stitcher.com/show/muscle-medicine-debunking-myths-around-nutrition-exercise (Stitcher), or on your favorite podcast platform.  Topics Covered: What Hashimoto's remission looks like The first steps to changing your lifestyle to improve your Hashimoto's symptoms Importance of finding a great doctor in treating your Hashimoto's How to address the root causes of your Hashimoto's How to change your diet, sleep, and exercise to help treat your Hashimoto's Resources Mentioned: https://foodbymars.com/ (Foodbymars.com) https://ouraring.com/ (Oura Ring) https://trk.chilisleep.com/SH95 (OOLER Sleep System) Follow Dr. Emily Kiberd: https://dremilykiberd.com/ (Thyroid Strong Website) http://instagram.com/dremilykiberd (Instagram) https://www.facebook.com/groups/thyroidstrong/ (Facebook)...

Hosted By: Keda Hubbard Jay Giles Keda and Jay going down memory lane in the world of WCW The Great American Bash, For the next couple of weeks they will be discussing some of The Great American Bash PPV Matches, Last one up 1999-2000 TGAB matches and a whole lot more!! ====================================== Next up Check out Hood Movie Sessions newest episode 8/31/21 for download. Before the movie review comes out watch The Night in Compton https://www.youtube.com/watch?v=uo6GRLmhgms ======================================= KedaNJayShow Check out the list!! Summertime episodes for KedaNJayShow available on friday's at 12 noon ET We Talk Next episodes are available for download on sunday's Once a month Hood Movie Sessions at the end of each month 30th or 31st More details on KedaNJayShow website https://www.kedanjayshow.com/ ============================================== Social Media Twitter @kedanjayshow @wtnpodcast @TheJayGiles @yeahuknowit1991 @MoneyMakerChris =========================== Listen live or Download https://www.kedanjayshow.com/ Mixlr: http://mixlr.com/kedanjayshow/ Stitcher: http://www.stitcher.com/s?fid=76371 Apple Podcast: https://itunes.apple.com/us/podcast/kedanjay-show/id1052532214?mt=2 Patreon: https://www.patreon.com/KedaNJayshow ============================= Shoutouts Wrestlebread Podcast @Wrestlebread | Linktree The Wrestling Court https://www.podomatic.com/podcasts/thewrestlingcourt TVZone Podcast Network https://www.podpage.com/the-tvzonepodcastnetworks-podcast/

Hosted By: Keda Hubbard Jay Giles Keda and Jay going down memory lane in the world of WCW The Great American Bash, For the next couple of weeks they will be discussing some of The Great American Bash PPV Matches, Second up 1995-1998 TGAB matches and a whole lot more!! ====================================== The Great American Bash Next episode matches are Kevin Nash vs Randy Savage(1999), Jeff Jarrett vs Kevin Nash(2000) ======================================= KedaNJayShow Check out the list!! Summertime episodes for KedaNJayShow available on friday's at 12 noon ET We Talk Next episodes are available for download on sunday's Once a month Hood Movie Sessions at the end of each month 30th or 31st More details on KedaNJayShow ============================================== Social Media Twitter @kedanjayshow @wtnpodcast @TheJayGiles @yeahuknowit1991 @MoneyMakerChris =========================== Listen live or Download https://www.kedanjayshow.com/ Mixlr: http://mixlr.com/kedanjayshow/ Stitcher: http://www.stitcher.com/s?fid=76371 Apple Podcast: https://itunes.apple.com/us/podcast/kedanjay-show/id1052532214?mt=2 Patreon: https://www.patreon.com/KedaNJayshow ============================= Shoutouts Wrestlebread Podcast @Wrestlebread | Linktree The Wrestling Court https://www.podomatic.com/podcasts/thewrestlingcourt TVZone Podcast Network https://www.podpage.com/the-tvzonepodcastnetworks-podcast/

Hosted By: Keda Hubbard Jay Giles Keda and Jay going down memory lane in the world of WCW The Great American Bash, For the next couple of weeks they will be discussing some of The Great American Bash PPV Matches, First up 1989-1992 TGAB and a whole lot more!! ====================================== Great American Bash Next episode matches are Flair vs Savage(1995), Lex Luger vs The Giant(1996), The Outsiders vs Flair/Piper(1997),Sting vs The Giant(1998) ======================================= KedaNJayShow Check out the list!! Summertime episodes for KedaNJayShow available on friday's at 12 noon ET We Talk Next episodes are available for download on sunday's Once a month Hood Movie Sessions at the end of each month 30th or 31st More details on KedaNJayShow ============================================== Social Media Twitter @kedanjayshow @wtnpodcast @TheJayGiles @yeahuknowit1991 @MoneyMakerChris =========================== Listen live or Download https://www.kedanjayshow.com/ Mixlr: http://mixlr.com/kedanjayshow/ Stitcher: http://www.stitcher.com/s?fid=76371 Apple Podcast: https://itunes.apple.com/us/podcast/kedanjay-show/id1052532214?mt=2 Patreon: https://www.patreon.com/KedaNJayshow ============================= Shoutouts Wrestlebread Podcast @Wrestlebread | Linktree The Wrestling Court https://www.podomatic.com/podcasts/thewrestlingcourt TVZone Podcast Network https://www.podpage.com/the-tvzonepodcastnetworks-podcast/

A What's Next ripercorriamo i fatti accaduti durante The Great American Bash e Road Rager, gli show che hanno infiammato la settimana appena trascorsa

KNJS EP. 251| END OF THE LINE PPVs PART 6 TGAB 09 by KedaNJayShow

Hosted By: Keda Hubbard & Jay Giles Episode 250: Keda & Jay going down memory in the world of The Great American Bash series. For the next 2 months they will be discussing TGAB PPVs, On this episode they discuss TGAB 08 and a whole lot more!! ====================================== Check out our shows live on Mixlr http://mixlr.com/kedanjayshow/ =============== #PodernFamily Want to join a great community of indie podcasters? Use the hashtag #PodernFamily on Twitter, and retweet others who use it! Simple as that! Since Keda and Jay's schedule is crazy at times, if you want to listen live follow them on Mixlr for random shows. All episodes will be available for download every Sunday. Subscribe to Kedanjayshow/WTN Podcast on: Itunes, Stitcher Radio, Player.FM, Satchel, Tunein and listen live on Mixlr. Twitter/Follow: @WTNPodcast @KedaNjayshow @TheJayGiles @JayMovieTalk Leave a Voicemail 202-827-5456 Thank you for listening comment, like and Share!

Hosted By: Keda Hubbard & Jay Giles Episode 249: Keda & Jay going down memory in the world of The Great American Bash series. For the next 2 months they will be discussing TGAB PPVs, On this episode they discuss TGAB 07 and a whole lot more!! ====================================== Check out our shows live on Mixlr http://mixlr.com/kedanjayshow/ =============== #PodernFamily Want to join a great community of indie podcasters? Use the hashtag #PodernFamily on Twitter, and retweet others who use it! Simple as that! Since Keda and Jay's schedule is crazy at times, if you want to listen live follow them on Mixlr for random shows. All episodes will be available for download every Sunday. Subscribe to Kedanjayshow/WTN Podcast on: Itunes, Stitcher Radio, Player.FM, Satchel, Tunein and listen live on Mixlr. Twitter/Follow: @WTNPodcast @KedaNjayshow @TheJayGiles @JayMovieTalk Leave a Voicemail 202-827-5456 Thank you for listening comment, like and Share!

Hosted By: Keda Hubbard & Jay Giles Episode 247: Keda & Jay going down memory in the world of The Great American Bash series. For the next 2 months they will be discussing TGAB PPVs, On this episode they discuss TGAB 05, and a whole lot more!! ====================================== Check out our shows live on Mixlr http://mixlr.com/kedanjayshow/ =============== #PodernFamily Want to join a great community of indie podcasters? Use the hashtag #PodernFamily on Twitter, and retweet others who use it! Simple as that! Since Keda and Jay's schedule is crazy at times, if you want to listen live follow them on Mixlr for random shows. All episodes will be available for download every Sunday. Subscribe to Kedanjayshow/WTN Podcast on: Itunes, Stitcher Radio, Player.FM, Satchel, Tunein and listen live on Mixlr. Twitter/Follow: @WTNPodcast @KedaNjayshow @TheJayGiles @JayMovieTalk Leave a Voicemail 202-827-5456 Thank you for listening comment, like and Share!

Hosted By: Keda Hubbard & Jay Giles Episode 246: Keda & Jay going down memory in the world of The Great American Bash series. For the next 2 months they will be discussing TGAB PPVs, On this episode they discuss TGAB 04, and a whole lot more!! ====================================== Check out our shows live on Mixlr http://mixlr.com/kedanjayshow/ =============== #PodernFamily Want to join a great community of indie podcasters? Use the hashtag #PodernFamily on Twitter, and retweet others who use it! Simple as that! Since Keda and Jay's schedule is crazy at times, if you want to listen live follow them on Mixlr for random shows. All episodes will be available for download every Sunday. Subscribe to Kedanjayshow/WTN Podcast on: Itunes, Stitcher Radio, Player.FM, Satchel, Tunein and listen live on Mixlr. Twitter/Follow: @WTNPodcast @KedaNjayshow @TheJayGiles @JayMovieTalk Leave a Voicemail 202-827-5456 Thank you for listening comment, like and Share!

Hosted By: Keda Hubbard & Jay Giles Episode 248: Keda & Jay going down memory in the world of The Great American Bash series. For the next 2 months they will be discussing TGAB PPVs, On this episode they discuss TGAB 06, and a whole lot more!! ====================================== Check out our shows live on Mixlr http://mixlr.com/kedanjayshow/ =============== #PodernFamily Want to join a great community of indie podcasters? Use the hashtag #PodernFamily on Twitter, and retweet others who use it! Simple as that! Since Keda and Jay's schedule is crazy at times, if you want to listen live follow them on Mixlr for random shows. All episodes will be available for download every Sunday. Subscribe to Kedanjayshow/WTN Podcast on: Itunes, Stitcher Radio, Player.FM, Satchel, Tunein and listen live on Mixlr. Twitter/Follow: @WTNPodcast @KedaNjayshow @TheJayGiles @JayMovieTalk Leave a Voicemail 202-827-5456 Thank you for listening comment, like and Share!

  Rachel  Hill is an author, writer, thyroid patient advocate, and creator of the award-winning website, The Invisible Hypothyroidism. Diagnosed with hypothyroidism and Hashimoto’s disease, she talks openly and honestly about what it’s like to have these diagnoses, as well as what has helped her and many others to recover their health and to thrive. She is passionate about helping those with hypothyroidism and giving them a voice, and is recognized as a valuable contributor to the thyroid community.  Listen in as Rachel shares…  - how she was first diagnosed with hypothyroidism as a teenager  - that before her diagnosis with Hashimoto’s (at 21), she had two severe flus, as well as symptoms that included uncontrolled loss of weight, migraines, irregular periods, acne, acid reflux, bloating, contact dermatitis, eczema, and the loss of about 80% of her hair  - how common thyroid disease is – and how few of us are talking about it  - that her symptoms left her bed-bound and immobile many days, and forced her to reduce her work commitments  - that she was originally prescribed T4 (Synthroid/levothyroxine) only, and this didn’t’ help – but she started researching alternate options and found a thyroid community  - that based on her research, she decided she wanted to try NDT (natural desiccated thyroid), which she had to self-source because no doctors in the NHS would prescribe it  - that not only has she struggled to get doctors to believe her, but many of the fellow thyroid patients she hears from have been in the same boat (including Lauren)  - the emotional toll of not being believed as a patient  - the importance of becoming an active participant in your own healthcare – in other words, becoming your own advocate  - how risky self-sourcing medications can be  - how important it is to always keep your doctors in the loop with regard to medications and treatments  - the best tests for thyroid function, and what they teach us: TSH, free T3, free T4, thyroid peroxidase antibodies (TPO), thyroglobulin antibodies (TgAb), and reverse T3 (which can often be the most difficult to obtain)  - why TSH isn’t enough of a test on its own in order to fully understand our thyroid function  - that Hashimoto’s and hypothyroidism are not mutually exclusive diagnoses  - that her husband, Adam, has acted as an advocate for her in medical settings  - that, disappointing as it may sound, female patients often find they are taken more seriously by doctors when they bring a male advocate with them to their appointments  - that her husband’s advocacy has brought them closer together – so much so that they have now written a book together!  - that her husband truly understood what she was experiencing when she explained Spoon Theory to him  - that fatigue and brain fog always troubled her when she was sick, and made her worry that she might have early-onset dementia  - that she now avoids gluten; when she does accidentally consume it, she can be knocked down for a few days  - the importance of making your workplace as comfortable and accommodating as possible for your needs when you have chronic illness  - the importance of conserving energy, even in small ways, when you live with chronic illness  - how her book, Be Your Own Thyroid Advocate, was designed to help thyroid patients – and was born from her blog, The Invisible Hypothyroidism  - info about her newest book with hubby Adam: You, Me, & Hypothyroidism, which charts both patient and loved-one POVs on navigating chronic illness  - how she started her award-winning blog  - that while the NHS is wonderful, it has let Rachel down as a thyroid patient – she wasn’t tested for hypothyroidism until she’d had symptoms for 4+ years  - how common thyroid disease is – 1 in 20 in the UK live with it, but as much as 60% of cases are undiagnosed  - the fact that although so many people likely have thyroid disease, it’s not commonly screened in the UK  - that UK doctors are forced to jump through additional hoops to screen and medicate thyroid disorders  - the importance of power in numbers to create change 

One of the main priorities in my practice is to stay on top of the latest cutting-edge research in Hashimoto’s disease and thyroid disorders. My latest round of research reviews involved six clinical studies that examined inositol and selenium and how they conferred major benefits in those with Hashimoto’s disease and subclinical hypothyroidism. The highlights of each study are summarized in a table at the end of this article for ease of reference. What are Inositol and Selenium? Before we get started, let’s do a quick review on the supplements inositol and selenium. Inositol is referred to as Vitamin B8 but is not actually a vitamin but a sugar. It naturally occurs in foods such as fruits (especially citrus), beans, grains and nuts. It helps provide structure to your cells and also affects the hormone insulin and how chemical messengers work in your brain. Some of you may wonder if myo-inositol and inositol are the same thing and the answer is yes. So if you buy a product that is just called “inositol”, this is the myo-inositol form. D-chiro-inositol is another form that works equally as well as myo-inositol, but the d-chiro-inositol has a slight edge in reducing excessive androgen levels in PCOS whereas the myo form is better with insulin resistance. I have mainly used inositol over the years with excellent results for the following: Polycystic ovarian syndrome (PCOS) Insomnia Anxiety Insulin resistance PMS Depression Fibrocystic breast disease Uterine fibroids Selenium is a trace element that is essential to well-being. It plays a role in the immune response, cell growth and viral defense as discussed in previous research including the studies of Huang et al. and Brownand and Arthur. Selenium also plays a huge part in the synthesis and function of thyroid hormones. It has antioxidant and anti-inflammatory properties and has been shown in previous investigations including those headed by Gartner et al., Landucci et al. and van Zuuren et al. to reduce an inflammatory condition in patients with Hashimoto’s thyroiditis. The first study I’d like to cover on inositol, selenium, and Hashimoto's disease came out of Italy in 2017 by Nordio and Basciani. That study was published in the European Review for Medical and Pharmacological Sciences entitled “Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism.” In that study, 168 patients ages 22 to 62 years had a TSH level between 3-6 mIU/L, elevated thyroid peroxidase antibody (TPO) and/or thyroglobulin antibodies (TgAb) and normal free T4 and T3 levels. They were randomized into two groups and were given either 83 mcg of selenium or a combination of 600 mg of myo-inositol and 83 mcg of selenium for six months. After six months of taking these supplements, all participants taking myo-inositol and selenium showed improvements in their TSH, free T4, thyroid peroxidase antibody (TPO) and thyroglobulin antibody (TgAb). The group taking only selenium had a decrease in TPO levels which we have known for a while now based on previous research. Thyroglobulin levels, however, decreased only in the inositol+selenium group. Additionally, subjects filled out a symptom questionnaire before and after which showed significant improvement in their thyroid-related symptoms. In 2013, the research team of Nordio and Pajalich examined the effects of supplementation with myo-inositol and selenomethionine on patients with subclinical hypothyroidism. Their article was published in Journal of Thyroid Research and was entitled, “Combined Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Subclinical Hypothyroidism Patients with Autoimmune Thyroiditis.” This study recruited 48 women with autoimmune thyroiditis with blood levels of thyroglobulin (Tg) and thyroid peroxidase (TPO) antibodies above 350 IU/L and TSH levels that were elevated between 4.01 mIU/L and 9.

We have never had any good studies looking at how food allergies, or more specifically food intolerances, affect Hashimoto’s disease. A recent paper, however, did show that people following a gluten-free diet can help heal Hashimoto’s disease.  In this article, Dr. Hedberg answers the question if food intolerances affect Hashimoto's disease? I was excited to find a new paper just published last month that looked specifically at food intolerances and Hashimoto’s disease. The paper was published in the Journal of the American College of Nutrition and it was entitled, “Evaluation of Correlations Between Food-Specific Antibodies and Clinical Aspects of Hashimoto’s Thyroiditis.” Let’s break down the study and see what food intolerances may be connected to Hashimoto’s disease. The authors do point out a previous study that showed TSH levels improved in people with Hashimoto’s disease who were lactose intolerant when they avoided consuming lactose. The aim of this study was to evaluate whether testing IgG antibodies for specific foods show differences in people with Hashimoto’s disease compared to those without Hashimoto’s disease. The authors wanted to find out if there were any specific foods connected to Hashimoto’s disease so that those individuals would know what to avoid to help their condition. How was the study done? 74 patients, 91.9% being female, with Hashimoto’s disease had blood testing done for 125 IgG food antibodies. Some of them were taking thyroid medication and some were not (28.17%). They also performed a thyroid ultrasound and tested them for thyroid-stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin antibodies (TgAb). Additional markers included body mass index (BMI), height, weight, blood pressure, and asked them how many symptoms they had. I was pleased to see a control group of 245 subject of which 54.7% were women. The control group was also tested for the same 125 IgG food antigens. To test the food antibodies they used enzyme-linked immunosorbent assay or ELISA which is a very popular technique for testing food intolerances. They broke the food intolerances down into these categories: Milk products Eggs Grains Legumes Nuts Fruits Vegetables Fish Seafood Meat Coffee and Tea They also took into account all the differences of the above blood markers, biomarkers, medication, and symptoms to see if they could find any correlations. They even looked at how frequently the subjects were eating specific food groups. What were the results? They found increased IgG antibody responses in 12 foods that were significant but these were elevated in both groups. Of the 12, only plum was significantly elevated in the Hashimoto’s group with egg white and barley showing borderline significance. Interestingly, almond was actually significantly less reactive in the group with Hashimoto’s disease compared to controls. Looking at the proportion of positive results however, only plum and barley were higher in those with Hashimoto’s disease but no significant difference with egg whites. Anti-gliadin IgG antibodies which are specific for gluten were tested but they did not find any differences between the two groups. The authors did not find any correlation with IgG food antibodies and symptoms of Hashimoto’s disease and hypothyroidism. The magnitude of reactivity from strongest to lowest in both groups was: Milk products and eggs > Grains > Nuts > Legumes > Fruits > Vegetables > Fish > Seafood > Meat > Coffee and Tea. Author Discussion The authors conclude that only plum was significant between the two groups with barley and egg white to a lesser extent. They did however find significant connections with thyroid volume and almond-specific IgG levels as well as for nuts, meat, and fish in those taking thyroid medication.

In this episode, Dr. Spencer, Professor of Medicine at University of Southern California, discusses the importance of testing for thyroglobulin-antibodies and thyroglobulin.   Important notes from this interview include: only 10% of nodules are malignant. when getting blood panels each six months, it is very the important to of measure TgAb every time.   consistency is important in blood tests, meaning, use the same laboratory and manufacturer's method every time. the most reliable method of testing TgAb is the machine manufactured by Kronus (RSR) or Roche.  When getting blood tests, be sure to request either of these manufacturers for TgAb results, each of these manufacturers are 100% sensitive. Beckman is  the most commonly used manufacturer, but only is 79% sensitive to TgAb results. always use the same Tg and TgAb methods and the same laboratory.   Dr. Spencer's major areas of research interest are thyroid physiology and pathology, thyroglobulin and thyroid cancer, immunoassay techniques, thyroid hormone metabolism, and the cost-effective use of thyroid tests. Her current research includes clinical significance of Tg and TgAb in patients with thyroid cancers, parameters for optimizing thyroid hormone suppression of TSH for DTC. Studies on hypothalamic/pituitary mechanisms for regulating TSH, and testing for thyroid dysfunction during pregnancy. Dr. Spencer earned her PhD from Glasgow University in Scotland. She then went on to complete two fellowships, one in Clinical Biochemistry at Glasgow, and the other at the National Academy of Clinical Biochemistry.     resources: www.thyroidlab.com/updates

Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease: human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). Methods: The aim of the present study was to investigate the role of the rs1990760 polymorphism within the IFIH1 gene in German patients with GD (n = 258), Hashimoto's thyroiditis (HT, n = 106), Addison's disease (AD, n = 195) and healthy controls (HC, n = 227) as well as in 55 GD families (165 individuals, German) and 100 HT families (300 individuals, Italian). Furthermore, the interaction between rs1990760 polymorphism with human leukocyte antigen (HLA) risk haplotype DQ2(DQA*0501-DQB*0201), the risk haplotypes DQ2/DQ8 (DQA*0301-DQB*0302) and the status of thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) in patients and families were analysed. Results: No significant differences were found between the allele and genotype frequencies for rs1990760 IFIH1 polymorphism in patients with GD, HT, AD and HC. Also no differences were observed when stratifying the IFIH1 rs1990760 polymorphism for gender, presence or absence of thyroid antibodies (GD: TRAb and HT:TPOAb/TgAb) and HLA risk haplotypes (DQ2: for GD and HT, DQ2/DQ8: for AD). Furthermore the transmission analysis in GD and HT families revealed no differences in alleles transmission for rs1990760 IFIH1 from parents with or without HLA risk haplotype DQ2 to the affected offspring. In contrast, by dividing the HT parents according to the presence or absence of thyroid Ab titers, mothers and fathers both positive for TPOAb/TgAb overtransmitted the allele A of IFIH1 rs1990760 to their HT affected offspring (61.8% vs 38.2%; p = 0.05; corrected p [pc] = 0.1). However, these associations did not remain statistically significant after correction of the p-values. Conclusion: In conclusion, our data suggest, no contribution from IFIH1 rs1990760 polymorphism to the pathogenesis of either Graves' disease, Hashimoto's thyroiditis or Addison's disease in our study populations. However, in order to exclude a possible influence of the studied polymorphism in specified subgroups within patients with autoimmune thyroid disease, further investigations in larger populations are needed.

Selenium Supplementation in Patients with Autoimmue Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations ROLAND GÄRTNER, BARBARA C. H. GASNIER, JOHANNES W. DIETRICH, BJARNE KREBS, AND MATTHIAS W. A. ANGSTWURM Departement of Endocrinology, Medizinische Klinik Innenstadt, University of Munich, D-80336 Munich, Germany In areas with severe selenium deficiency there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells. Selenium-dependent enzymes also have several modifying effects on the immune system. Therefore, even mild selenium deficiency may contribute to the developpement and maintenance of autoimmune thyroid dideases. We performed a blinded, placebo-controlled, prospective study in female patients (n = 70; mean age, 47.5 + 0.7 yr) with autoimmune thyroiditis and thyroid peroxidase antibodies (TPOAb) and/or Tg antibodies (TgAb) above 350 IU/ml. The primary end point of the study was the change of TPOAb concentrations. Secondary end points were changes in TgAb, TSH, and free thyroid hormone levels as well as ultrasound pattern of the thyroid and quality of life estimation. Patients were randomized into 2 age- and antibody (TPOAb)-matched groups; 36 patients received 200 µg (2.53 µmol) sodium selenite/d, orally, for 3 months, and 34 patients recieved placebo. All patients were substituted with L-T4 to maintain TSH within the normal range. TPOAb, TgAb, TSH, and free thyroid hormones were determined by commercial assays. The echogenicity of the thyroid was monitored with high resolution ultrasound. The mean TPOAb concentration decreased significantly to 63.6% (P = 0.013) in the selenium group vs. 88% (P = 0.95) in the placebo group. A subgroup analysis of those patients with TPOAb greater than 1200 IU/ml revealed a mean 40% reduction in the selenium-treated patients compared to a 10% increase in TPOAb in the placebo group. TgAb concentrations were lower in the placebo group at the beginning af the study and significantly further decreased (P = 0.018), but were unchanged in the selenium group. Nine patients in the selenium-treated group had completely normalized antibody concentrations, in contrast to two patients in the placebo group (by x2 test, P = 0.01). Ultrasound of the thyroid showed normalized echogenicity in these patients. The mean TSH, free T4, and free T3 levels were unchanged in both groups. We conclude that selenium substitution may improve the inflammatory activity in patients with autoimmune thyroiditis, especilally in those with high activity. Whether this effect is specific for autoimmune thyroiditis or may also be effective in other endocrine autoimmune diseases has yet to be investigated. (J Clin Endocrinol Metab 87: 1687-1691, 2002)