Lauren's website is laurencunningham.co and you can find her ebook directly here. Follow her on Instagram @laur_cunningham.Check out our new website, myimmunesystempod.com, where you can get in contact with Chelsey, listen to old episodes, learn about the RA Warrior Group, buy a signed copy of Chelsey's upcoming book, and apply to be a guest on the show.Don't forget to rate and review the show, and follow us on Instagram and Facebook @myimmunesystempod***Any information discussed in this podcast is strictly my opinion and those of my guests and are for informational purposes only. We are speaking from our personal experiences and you should always consult with your doctor or medical team.
Even though the Chiefs face a daunting task in stopping Derrick Henry and the Titans on Sunday, there are things for Chiefs fans to still be excited and positive about despite the current record. Nate Taylor, Seth Keysor, and Joshua Brisco dive into reasons why Patrick Mahomes, Travis Kelce and the offense are trending UP, some recent improvements in the secondary, a gameplan than might work against Tennessee and more on Time's Ours. Learn more about your ad choices. Visit megaphone.fm/adchoices
Secondary principals in South Auckland say the government's plans for reopening schools will be too late for many of their students. Students in years 11, 12 and 13 will be allowed back to school in alert level three areas next Tuesday.The Principal of Tangaroa College in Otara Davida Suasua, says nearly 40 per cent of her Year 13 students are now working full time as essential workers to support their families. She says many of these students had planned to go to university next year, but that will now not happen. She speaks to Kathryn along with Pete Jones, Principal of Manurewa High School.
The move to reopen schools for senior students at the start of next week poses a significant risk for increasing case numbers, says a government adviser. Secondary school students in Years 11-13 who live in alert level 3 areas will be able to return to the classroom from next Tuesday. Dr Dion O'Neale is a physicist and contagion modeller with Te Pūnaha Matatini, a group of experts funded to provide advice on the Covid-19 response. He says that while reopening for students presents opportunities for some, it risks making things worse for others. He spoke to Susie Ferguson.
Ryan, Graham, and Joe are here to answer your listener questions! Hurrah! From a new World Cup tournament for the nearly-rans, to the intricacies behind obtaining coaching badges, we have you covered! -Instead of a World Cup every two years, what about a 2nd World Cup with nations that just missed the main World Cup? -Do you think that the new Newcastle owners are being overly outwardly ambitious? -What are coaching badges and how do you obtain them? -Why aren't South American club soccer leagues more popular in the USA? -Why did they change the offside rule to negate an offside if a defender makes a defensive play on the ball? -The US plays its home matches all over the country. In England, all or nearly all of their home matches are at Wembley. Is one or the other more common in international soccer, particularly among the best teams? -I heard that many Rangers fans would rather cheer for England than Scotland (and many Celtic fans cheer for Ireland). Is there any truth to this? Sponsors! BetterHelp! Get 10% off your first month of customized online therapy by going to BetterHelp.com/theathletic! Sonos! Are you looking for some high-quality audio? Head to Sonos.com to find exactly what you're looking for. Harry's! You can get a 5-blade razor, a weighted handle, foaming shave gel, and a travel cover, all for just $3 when you go to Harrys.com/TSS! American Giant! Explore American Giant's collection of durable essentials at american-giant.com and use promo code TSS at checkout to get 20% off! Helix Sleep! Helix is offering up to $200 off all mattress orders and two free pillows to TSS listeners who visit HelixSleep.com/TSS! Papa & Barkley! Go to PapaandBarkleyCBD.com/TSS to get 20% off your first purchase! Learn more about your ad choices. Visit megaphone.fm/adchoices
To support this ministry financially, visit: https://www.oneplace.com/donate/1085/29 What's the difference between a golf ball and your tired old car that needs a few thousand dollars in repairs? You can still drive a golf ball 200 yards! Today on MoneyWise, Rob West answers the question of how to know when it's time to pay for repairs or replace your car. If you've tried to buy a used car recently, you probably noticed the high prices. Why are they high? Demand for cars has risen while the supply of new cars has fallen. People who might normally buy new cars aren't able to find them, which leads them to buying dependable used cars. This increased demand in used cars has caused prices to rise. Rob mentioned some of the reasons the new car supply has fallen: There is a computer chip shortage, due to a fire at a factory in Japan. This caused a worldwide shortage of chips used to regulate modern vehicle engines and transmissions. No new chips mean no new cars. Auto manufacturing plants are having a difficult time keeping their workforce up due to the COVID-19 pandemic. This further decreases production. Secondary manufactures are dealing with the same issues, creating a shortage of the thousands of parts needed to assemble cars. Some automakers have ceased operations temporarily. Vehicle wholesaler Manheim, which also monitors and scores used car values, said they're the highest they've ever been. The upward trend in used car values has started to level out just a bit, but prices are still way above last year's numbers. Cars.com says used-car prices are still going up, but the rate of climb in prices has started to taper off in recent months. Their used car median listing price in August was $24,000, up almost 35% from last year. So does all of this mean you should wait until used vehicle prices get back to what we remember as normal? That depends on how much life is left in the vehicle you're trying to replace. Experts who've been monitoring the chip shortage and other supply chain problems say it will take time for new car inventories to increase. That means used car prices won't drop anytime soon. So in this inflated market, how do you know if it's worth it to repair your current vehicle? Consumer expert Clark Howard recently tackled that question. He suggests: If the repairs cost less than half of the car's value, go ahead and have the work done. If the repairs cost between half and the full value of the car, have the work done only if that means you'll get another year out of the vehicle. Bottom line, if you can afford to wait until prices decline you'll more than likely come out ahead. Next, Rob answered a few listener questions including the following: I received a $14,000 settlement due to an injury. Do I tithe on the whole amount or on the amount after expenses? I have around $170,000 in debt including a mortgage, auto loan and credit card. We have enough to pay off these debts with around $65,000 left over. Should we pay them off all at once with our savings or take them on one at a time? Do savings accounts have a Payable on Death feature allowing me to designate a beneficiary for that account so that it avoids probate? I'm getting married soon, what is a good place to start as a married couple to be good stewards of God's money? Remember, you can call in to ask your questions 24/7 at (800) 525-7000 or email them to Questions@MoneyWise.org. Also, visit our website at MoneyWise.org where you can listen to past programs, connect with a MoneyWise Coach, and even download free, helpful resources like the free MoneyWise app. Like and follow us on Facebook at MoneyWise Media for the very latest discussion! And remember that it's your prayerful and financial support that keeps MoneyWise on the air. Help us continue this outreach by clicking the Donate tab on our website or in our app.
Monica Irelan Karas - Veteran's Benefits Attorney with Tabak Law Firm based out of Milwaukee Wisconsin with Offices located across the USA
The Tampa Bay Buccaneers defeated the Philadelphia Eagles on Thursday night football, but it wasn't without more problems. The Buccaneers lost cornerback Richard Sherman to a hamstring injury and we have a caller on the show that voices his concern about the secondary continuing to be battered and bruised. Normally we give our biggest takeaways on Tuesdays but we dive into those now. For starters, with the coaching upheaval in Las Vegas, there are some names on the Bucs staff that could become top targets and candidates for the Las Vegas Raiders' Head Coach position after the 2021 season. What if we told you that Mike Evans was no longer the top wide receiver on the team? The numbers are pretty revealing that what James told you about starting in August is beginning to come to fruition - and with no signs of slowing down. Even with one fewer game played than Evans or Chris Godwin, Antonio Brown is now leading the team in targets for Tom Brady. All three receivers are close in terms of receptions and yards, but AB seems to be Brady's go-to guy when he's on the field. Ronald Jones may be looking out for his future after the season and it isn't out of the realm of possibility that 2021 will be the last season we see RoJo in a Buccaneers uniform. The more Leonard Fournette asserts himself as the top guy, the more likely it is that RoJo is out the door. Forget the Arizona Cardinals being undefeated or the Buffalo Bills looking to be unstoppable - the Bucs are still the best team in football and it isn't particularly close. The Locked On Bucs Podcast explains why. Follow & Subscribe to the Locked On Bucs Podcast on these platforms… Apple: https://apple.co/3iOePFk Spotify: https://spoti.fi/3BwlScY Audacy: https://bit.ly/3FAcIhV Google: https://bit.ly/2X0IEdS Megaphone: https://bit.ly/3uZOcSo Follow Locked On Podcast Network on Twitter: https://twitter.com/LockedOnNetwork Check out all of our NFL Coverage: linktr.ee/lockedonnfl Follow James on Twitter: https://twitter.com/JYarcho_BUCS Follow David on Twitter: https://twitter.com/DHarrison82 Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Amid the early season struggles of 2021, Locked On Dolphins takes a look at which secondary players should be considered long-term building blocks. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Samantha Bunten, Senior NFL Analyst and Content Director for NBC Sports and Sunday Night Football, tells Mike "Chico" Bormann she is most scared of the Browns secondary against the Cardinals offense as they look over Cleveland's concerns against the last undefeated team in the NFL Friday night on "Chico After Dark." See omnystudio.com/listener for privacy information.
Paper discussed in today's episode:An Association Between Positive Airway Pressure (PAP) Device Manufacturer and Incident Cancer?: A Secondary Data Analysis
Usayd Koshul and Joseph Herff are back to breakdown the Bears win over the Las Vegas Raiders, how apparent Justin Fields growth has been, how running back Khalil Herbert fits the Bears offense, Khalil Mack's revenge game, and some quick talk regarding the Bears-Packers matchup set for Sunday afternoon. Follow Fireside Bears on Twitter, YouTube, Tik Tok, Facebook, and Instagram: @FiresideBears See omnystudio.com/listener for privacy information.
A school principal says they may face teacher shortages in some areas if even a small number refuse to be vaccinated. By the start of next year all school staff who have contact with students must be fully vaccinated. Macleans College principal Steve Hargreaves told Morning Report the vast majority of his 240 staff are willing. "I have asked gently around the senior staff, what have they heard and my feeling is that we're going to have a very good uptake, and we have already," he said. "We've got 240 staff, and on the law of averages, we're going to have somebody who's a bit reluctant, maybe for medical reason, or they just need more information, or perhaps they're wondering how it relates to their particular job in school. "I can anticipate there'll be some discussions around those issues with certain staff, and it might only be three or four or five, but, you know, we've got a teaching shortage in some subjects, and if it means that somebody leaves then that could cause problems." Hargreaves, who's also the president of the Auckland Secondary School Principals Association, will meet with the Ministry of Education today.
Hour 3: The Packers were able to beat the Bengals despite missing several key players. Did you see enough from the Packers' secondary on Sunday to give you confidence in life without Jaire Alexander? See omnystudio.com/listener for privacy information.
Please join author Milton Packer and Associate Editor Justin Ezekowitz as they discuss the Perspective "Heart Failure and a Preserved Ejection Fraction: A Side-by-Side Examination of the PARAGON-HF and EMPEROR-Preserved Trials." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the Journal and its editors. We're your co-hosts. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center. Dr. Greg Hundley: And I'm Dr. Greg Hundley, associate editor, director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Greg, it really is so great to be back with you chatting about the papers here in the Journal. Thank you for going solo and for just being the greatest partner on earth. Thank you for that. For everyone listening in, we are back with some gusto and especially with this feature discussion today. You are not going to want to miss it. We are talking to Dr. Milton Packer as well as Dr. Justin Ezekowitz. We are going to compare PARAGON and EMPEROR-Preserved trials in heart failure with preserved ejection fraction. A really interesting discussion you're not going to want to miss, but now let's start with some papers in today's issue. I'd like to start, please. Dr. Greg Hundley: You bet. Dr. Carolyn Lam: Greg, you know the optimal duration of antiplatelet therapy in patients with high bleeding risk with or without oral anticoagulation after coronary stenting? Well, that still remains a question. Today's paper is a pre-specified subgroup analysis of the MASTER DAPT trial and reports on the outcomes of patients with or without an oral anticoagulation indication in this study. Dr. Greg Hundley: Right, Carolyn. Remind us. What was the MASTER DAPT trial? What did it test? Dr. Carolyn Lam: Ah. MASTER DAPT investigated an abbreviated or one-month versus a non-abbreviated or three to 12-month dual antiplatelet therapy and a stopping of antiplatelet therapy at six months strategy after coronary stenting in an all-comer population at high bleeding risk. Dr. Greg Hundley: Carolyn, what did this subgroup analysis of outcomes in patients with and without oral anticoagulation show? Dr. Carolyn Lam: At 12 months of follow-up, ischemic and net risk did not differ with abbreviated versus non-abbreviated anti-platelet regimens in both subgroups, although significantly fewer clinically relevant bleeding events occurred in the group without an oral anticoagulation indication. Whereas only numerically fewer bleeding events occurred in the group with an oral anticoagulation indication that did not reach statistical significance. This subgroup analysis from the MASTER DAPT trial really adds additional evidence that dual antiplatelet therapy beyond one month in patients with or without an indication for oral anticoagulation really has no benefit and only increases bleeding risk. Dr. Greg Hundley: Oh, very important finding, Carolyn. Great research. Well, Carolyn, how the extracellular matrix microenvironment modulates the contractile phenotype of vascular smooth muscle cells and confers vascular homeostasis really remains elusive. Thus, these investigators led by Professor Wei Kong at Peking University applied protein-protein interaction network analysis to explore novel extracellular matrix proteins associated with the vascular smooth muscle cell phenotype. Dr. Carolyn Lam: Huh. Interesting. What did they find, Greg? Dr. Greg Hundley: Right, Carolyn. By combining an in-vitro and an in-vivo genetic mice vascular injury model, they identified nidogen-2, a basement membrane glycoprotein, as a key extracellular matrix protein for maintenance of vascular smooth muscle cell identity. Nidogen-2 exerted its protective function via direct interaction and modulation of Jagged1-Notch3 signaling. Dr. Carolyn Lam: Wow! Nidogen-2 and Jagged1-Notch3. I always learn so much. What are the clinical implications, Greg? Dr. Greg Hundley: Right, Carolyn. Perhaps targeting nidogen-2 to precisely modulate Jagged1-Notch3 signaling, well, that may provide novel therapeutic strategy for atherosclerosis and post-injury restenosis. Dr. Carolyn Lam: Very nice. Well, in the next paper, we discuss inflammation in heart failure. We know that inflammation contributes to the pathogenesis of heart failure, but there is limited understanding of inflammation's potential benefits. Interesting, huh? Well, these authors, Dr. Wollert and colleagues from Hannover Medical School in Germany, identified an adaptive crosstalk between inflammatory cells and cardiomyocytes that protects against persistent afterload stress-induced heart failure in mice. Monocytes and macrophages produced myeloid-derived growth factor in the pressure overloaded myocardium to augment SERCA2a expression in cardiomyocyte's calcium cycling and contractility. Myeloid-derived growth factor plasma concentrations were also found to be elevated in patients with aortic stenosis and to decline after aortic valve implantation indicating that pressure overload also triggers myeloid-derived growth factor release in humans. Dr. Greg Hundley: Carolyn, really informative preclinical science, but what are the clinical implications? Dr. Carolyn Lam: Ah. These observations molecularly defined a feature of the inflammatory response to hemodynamic overload that protects against heart failure development. Inflammation's beneficial trade therefore need to be considered when developing inflammation as a therapeutic target in heart failure. All of this is really discussed in a lovely editorial entitled Inflammation and Heart Failure: Friend or Foe? That's by Drs. Hajjar and Leopold. Dr. Greg Hundley: Great job, Carolyn. Well, my next paper focuses on resistant hypertension. Carolyn, although lifestyle modifications generally are effective in lowering blood pressure among patients with unmedicated hypertension or those treated with one to two antihypertensive agents, the value of exercise and diet for lowering blood pressure in patients with resistant hypertension is unknown. To address this, Professor James Blumenthal and co-authors at Duke University Medical Center enrolled 140 patients with resistant hypertension with an average age of 63 years, 48% women, 59% black, 31% diabetes, and 21% with chronic kidney disease and randomly assigned them to A, a four-month cardiac rehab center-based program of lifestyle modification. We're going to call that C-LIFE, consisting of dietary counseling, behavior and weight management, and exercise. Or number 2 or the B, a single counseling session providing standardized education and physician advice. We'll call that SEPA. Dr. Greg Hundley: The primary endpoint was clinic measured systolic blood pressure. Secondary endpoints included 24-hour ambulatory blood pressure and selective cardiovascular disease biomarkers including baroreflex sensitivity to quantify the influence of baroreflex on heart rate; high-frequency heart rate variability to assess vagally-mediated modulation of heart rate; flow-mediated dilation to evaluate endothelial function; and pulse wave velocity to assess arterial stiffness; and then finally left ventricular mass to characterize left ventricular structure and remodeling. Dr. Carolyn Lam: Wow! That is a very, first of all, important clinical question. Then also, just very intricate methodology in assessing this. What did they find? Dr. Greg Hundley: Right, Carolyn. Between-group comparisons revealed that the reduction in clinic systolic blood pressure was greater in C-LIFE compared with SEPA. Next, 24-hour ambulatory systolic blood pressure also was reduced in C-LIFE with no change in SEPA. Then next, compared with SEPA, C-LIFE resulted in greater improvements in baroreflex sensitivity, high-frequency heart rate variability, and flow-mediated dilation. There was no between-group differences in pulse wave velocity or LV mass. Dr. Greg Hundley: Carolyn, diet and exercise can lower blood pressure in patients with resistant hypertension. When delivered in a cardiac rehabilitation setting, a four-month program of diet and exercise as adjunctive therapy, results in a significant reduction in clinic and ambulatory blood pressure, and improvement in selected cardiovascular disease biomarkers. Dr. Carolyn Lam: Wow! Really nice, Greg. Okay. Well, looks like we're all going to round up already with what else there is in today's issue. Let me start. There's an exchange of letters between Drs. Fang and Vinceti regarding the article Blood Pressure Effects on Sodium Reduction: Dose-Response Meta-analysis of Experimental Studies. Dr. Greg Hundley: Right, Carolyn. I've got a few things in the mail bag. First, Professor Anker has a Research Letter regarding the Kidney Function After Initiation and Discontinuation of Empagliflozin in Heart Failure Patients With and Without Type 2 Diabetes: Insights From the EMPERIAL Trials. Dr. Gerstenfeld has an ECG challenge entitled Atrioventricular Block with Narrow and Wide QRS: The Pause That Refreshes. Then lastly, Dr. Donald Lloyd-Jones has an AHA update regarding the American Heart Association's focus on primordial prevention. Well, Carolyn, I can't wait to hear this fantastic feature discussion with you and Dr. Packer. How about we jump to that? Dr. Carolyn Lam: Great. Let's go, Greg. Dr. Carolyn Lam: Because side-by-side exam of PARAGON and EMPEROR is like side-by-side of... Dr. Justin Ezekowitz: You can compare our new and our old prime minister much like your paper did. Dr. Milton Packer: Yeah, yeah. Dr. Justin Ezekowitz: There are [crosstalk] and it could be viewed until they perform in the broader world how it goes. You don't quite know. Dr. Milton Packer: The only problem is you can't do a head-to-head comparison of the old prime minister and the new prime minister. Dr. Justin Ezekowitz: That is true except that the head-to-head comparison includes excellent care by both the new and the old. I think that comparison's going to be pretty equal. I think we can case-control that one. Dr. Carolyn Lam: I really liked that that was politically correct because we are recording. Everybody, welcome to the feature discussion. I am here with Dr. Milton Packer from Baylor and he really needs no introduction. We're discussing heart failure with preserved ejection fraction. As well as our associate editor, Dr. Justin Ezekowitz from University of Alberta. Hence, in case anybody's wondering, we were talking about the Canadian elections. Let's just launch straight into it, a side-by-side comparison of PARAGON and EMPEROR-Preserved. Dr. Packer... Milton, if I may, what in the world drove you to do this? Dr. Milton Packer: My God. Oh, my God. Yes. Dr. Carolyn Lam: Tell us about what drove you to do this and please, if you could just summarize the results. Dr. Milton Packer: Well, let me just say from the outset that this was a commentary, not an original research article. Dr. Carolyn Lam: Yes. Dr. Milton Packer: The commentary was motivated by two very straightforward observations. We had two large scale outcome trials of two different drugs in heart failure with a preserved ejection fraction. I was privileged to serve as you were, Carolyn, on the leadership committees of both trials. It's not as if we have involvement in only one trial. We have involvement in both trials and we are very proud of that involvement. Dr. Milton Packer: One trial came in with a effect size of about 13% on its primary endpoint with a borderline P-value. A second trial, EMPEROR-Preserved, came in with a 21% reduction and its primary endpoint with a really small and persuasive P-value. The two patient populations in the two trials were really amazingly similar. We wanted to understand why it was 21% in one trial and persuasively so and why it appeared to be smaller in the PARAGON trial with sacubitril/valsartan. We thought, well, maybe that difference was related to how endpoints were defined or maybe that difference was related to the influence of ejection fraction. The reason we got excited about that was that as almost everyone knows, PARAGON found an influence of ejection fraction on the effect of sacubitril/valsartan in patients with HFpEF. We found an influence of ejection fraction on the effect of empagliflozin in HFpEF in EMPEROR-Preserved. We wanted to understand whether that influence was similar in the two trials. Dr. Milton Packer: Just to make life simple, PARAGON had created certain cut points for ejection fraction. They had presented and previously published in Circulation endpoints based on those cut points of ejection fraction. All we did was we used their endpoints and their cut points, and we put the two trials side by side. We did not do a statistical comparison of the effect size. There're actually no P-values in the whole commentary. But what we wanted to see was: Was the shape of the ejection fraction influence relationship similar or different in the two trials? Well, very simple. In PARAGON, as has been reported, there was a linear relationship: as ejection fraction increased, the effect of sacubitril/valsartan got smaller. In EMPEROR-Preserved, there was also an attenuation at a highest ejection fraction, but the relationship wasn't linear. It was like a hockey stick. It was flat and then went up at an ejection fraction over 62.5, which was the cut point that PARAGON used. Dr. Milton Packer: When we compared patients between the low 40s and the low 60s, the effect size in empagliflozin appeared to be larger than the effect size of sacubitril/valsartan in that ejection fraction group using the same endpoints. In fact, for hospitalizations for heart failure, which is really what SGLT2 inhibitors do, it was twice as great with empagliflozin in EMPEROR-Preserved than with sacubitril/valsartan in PARAGON-HF. We thought this was really interesting. We put the pictures up side by side. We wrote a commentary and Circulation was so kind to accept it. Dr. Carolyn Lam: Oh, but Milton, you were very, honestly as always, very clever to have done this analysis. But if I could reiterate a few things for the audience, which is very important. First of all, as you rightly first pointed out, it's a perspective piece. It is not a head-on comparison with P-values. It could not be. Let's just also give the audience a bit of background in that PARAGON included patients with an ejection fraction of 45% and above. EMPEROR-Preserved was above 40. PARAGON looked at total heart failure hospitalizations and cardiovascular death as a primary outcome. EMPEROR looked at first cardiovascular death or heart failure hospitalization. Dr. Carolyn Lam: Let's just remember the designs were different. Of course in the comparison, PARAGON compared sacubitril/valsartan versus valsartan. I like the way you very carefully wrote in your study that it was more a study of neprilysin inhibition since it's sacubitril/valsartan against valsartan and it was empagliflozin versus placebo. We know that it's important to state that as a basis. Then really important to say to everybody out there, pick up our journal. You must look at this bigger. I myself have already cited it at least twice already, Milton, because people will just naturally ask that. "Are the results different because of ejection fraction or different endpoints?" What you did there in that beautiful figure is that you tried as best as you can to match it up in terms of ejection fraction bins and match it up in terms of hospitalizations. There. I just wanted to state those few things, but I'm really- Dr. Milton Packer: Oh, no. No. Carolyn, you're 100% right. That's why there are couple of things. I just want to underscore what you said because I think your points were spot on. First of all, we really lined up the endpoints and the ejection fraction. We tried our best to compare apples and apples. It would not have been a useful exercise for us to compare different endpoints and different ejection fraction subgroups. But I just want to make sure that everyone understands: I'm a big fan of sacubitril/valsartan and I'm a big fan of neprilysin inhibition. As you know, both PARADIGM-HF and PARAGON-HF weren't really tests of sacubitril/valsartan; they were tests of neprilysin inhibition. They were great tests at that. PARAGON in particular was a great test of that. We're comparing neprilysin inhibition and SGLT2 inhibition. Dr. Milton Packer: But here's my most important point: we do not want people to choose one over the other. That was not the intent. We think that there are data in patients with certain ejection fractions, let's say between 40 and 60, I'm just creating a range, where both interventions are appropriate. Now I understand there are cost considerations and I don't want to minimize that, but we are not suggesting that anyone prefer one drug over the other. All we wanted to do was we wanted to ask the question: Since the effect size in one trial seemed to be different than the effect size in the other trial, what were the ejection fraction subgroups that represented that difference? We found that the patients with ejection fractions greater than 60, 65% did not contribute to that difference. It was the patients with lower ejection fractions that contributed to the difference. I hope that's helpful. Dr. Carolyn Lam: Ah. That's wonderful. Justin, have you recovered from the talk about the Canadian elections? Dr. Justin Ezekowitz: Oh. I have indeed. Dr. Carolyn Lam: I'm on swinging. Dr. Justin Ezekowitz: I have indeed. Thanks for recognizing that Canada just had a major election we carried out in six weeks. But, Milton, I really enjoyed reading this. Maybe I can just ask you about two elements within this perspective piece, which is number 1, what's incredibly concordant is a lack of difference across cardiovascular death for both agents in both trials regardless of the trial differences and the potential differences in patient populations recruited; that's number 1. It's incredibly flat for cardiovascular death. Dr. Justin Ezekowitz: But number 2 is there is a danger in comparing trials even non-statistically. That's often a pitfall we get into, but we have to put some frame of reference on that. What is the one or two key things you think differ between PARAGON and EMPEROR-Preserved that you say, "You really need to look at these trials differently"? Those two questions came to mind when looking at this great figure that you produced. Dr. Milton Packer: Okay. The first question is so much easier and that is that these drugs don't reduce cardiovascular deaths. Full stop. It's really interesting because sacubitril/valsartan reduces cardiovascular death in people with ejection fractions of 40% or less, but not in patients with ejection fraction greater than that. The primary effect is heart failure hospitalizations. Empagliflozin didn't reduce cardiovascular death even in patients with the ejection fraction less than 40% or greater than 40%. What we're really, really talking about two drugs where the major effect is a reduction in heart failure hospitalizations. That comes out whether you do the analysis as time-to-first-event or total heart failure hospitalizations. Dr. Milton Packer: Of course, we're looking forward to the DELIVER trial with dapagliflozin. My own personal expectation is they're going to come out with a very striking effect on heart failure hospitalizations and not on cardiovascular deaths. Cardiovascular deaths in patients with HFpEF is really... It's a hard goal because only half of the deaths are cardiovascular. These patients have so many comorbidities that influence prognosis. The other thing, which is really important, is that heart failure hospitalizations only represented 18% of all hospitalizations in these patients; it's really small. I think of empagliflozin as being a treatment of the heart failure of HFpEF, not a treatment for HFpEF. I hope that makes sense. Justin, what was your second question? Dr. Justin Ezekowitz: Absolutely. Dr. Milton Packer: Oh, the differences between- Dr. Justin Ezekowitz: Yeah. Thank you, Milton. Dr. Milton Packer: Okay. There's always differences between two trials. As I said before, Carol and I were involved in both trials. They were done slightly at different times. They didn't overlap. Remember that the cut points in the two trials, one was 40%, one was 45%, really didn't matter to our analysis because we corrected for that in our ejection fraction subgroups. I was actually really much more impressed by the similarities than by the differences, but here's the catch. HFpEF is an incredibly heterogeneous disease. When we look at baseline characteristics, we're looking at means, medians, percentages. We're not picking up on any heterogeneity and there's a lot of heterogeneity. I actually think that HFrEF is a reasonably homogeneous disease. I think HFpEF is an incredibly diverse disease with a whole host of different disorders. What I'm amazed by is that we actually got an effect size that was greater than 20% in an all-comers HFpEF analysis. Dr. Milton Packer: But in all honesty, Justin, it wasn't really all-comers. We excluded people with BMIs over 45. There are a lot of patients who are obese and had BMIs greater than 45 who have HFpEF. By the way, especially in Texas. I didn't say that. We didn't enroll those patients. In all honesty, if I had to do it all over again, I would have. By the way, PARAGON didn't enroll them either. Dr. Carolyn Lam: Well, this is an incredible conversation. I know that we could just do a whole hour of chatting about what this implies for the higher ejection fraction, what this implies for how we should be treating heart failure. I don't even dare to ask for some last words maybe from both Justin and Milton, but recognizing that the time is short, anything else to add? Dr. Milton Packer: I think Justin should do last words. Dr. Justin Ezekowitz: Well, let me summarize by saying there is a hockey stick. We love hockey sticks in Canada. A simple and an excellent comparison. I think people should really look at that figure to understand it, but do not undertreat your patients with HFpEF and look at these with a grain of salt. Thanks for joining us, Milton. Thanks, Carolyn. Dr. Milton Packer: Thank you so much. Dr. Carolyn Lam: On behalf of Greg and I, you've been listening to Circulation on the Run. Thank you so much for joining us today and don't forget to tune in again next week. Dr. Greg Hundley: This program is copyright of the American Heart Association 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors, or of the American Heart Association. For more, visit ahajournals.org.
Guy and Eitan talk about various topics related to SQL Server, including upcoming virtual events, interesting new scripts from our toolbox, and more! Relevant links: SQL Server 2016 SP3: Last Service Pack for SQL Server SQL Server Release Dates and Product Lifecycle PASS Data Community Summit - November 8-12, 2021 Development Lifecycle Basics for DBAs Group By Conference 2021 SSDT Methodologies & Features for DB DevOps Level up your skills with Bicep! TRY/CATCH and Transactions in SQL Server: TRY...CATCH (Transact-SQL) @@TRANCOUNT (Transact-SQL) XACT_STATE (Transact-SQL) SET XACT_ABORT (Transact-SQL) Today's Madeira Toolbox Round-Up: Table and Index High Unused Space.sql DBCC CLEANTABLE (Transact-SQL) DatabaseIntegrityCheck - Minimal check on PRIMARY, Full check on SECONDARY.sql DatabaseIntegrityCheck by Ola Hallengren Shrink_Database_File_in_Specified_Increments.sql SARGability Week by Erik Darling
(0:00) The second hour opens up with the callers weighing in on agenda free friday. (14:58) Bob Socci joins the show to discuss the Patriots. (23:14) The callers weigh in on agenda free Friday! (31:48) Looking at the Patriots secondary
Summary: The supply chain has raised a lot of concerns, especially in consideration of the upcoming holiday season. Carl Gould comes on the podcast to talk about this, and to give advice on what we can do to compensate for these disruptions. If you see something that you know you're going to need, it's probably wise to get it now—especially if it's trendy, or comes from a manufacturer overseas. Tune in to get advice on how to adjust to some of these changes in preparation for the coming months. Highlights: -The supply chain has been affecting all aspects of life lately—if you see something you want now, it's best to go ahead and get it -Especially in consideration of the holiday season, it's important to start thinking about purchasing things soon since the supply chain is so far behind -Popular and trendy items will be especially hard to get ahold of at this point -The category of item will likely be available, but not the specific item itself -We don't have the labor force to load/unload ships and ships are leaving without being fully loaded -Secondary markets are equally robust, and worth considering (i.e. Ebay, Facebook Marketplace, Poshmark, etc.) -The supply chain disruption affects many areas of your life -Anything coming from overseas, especially apparel, is going to require a long wait -Europe is going to have disruptions as well -It may be a good year to give things that are experiential rather than tangible Useful Links: Financial Survival Network 7 Stages Advisors
On this episode of the Write.Publish.Market podcast Jodi is talking about your book's secondary audiences. Now you might be thinking, “What the heck is a secondary audience?” and Jodi is sharing what it is and why you need to be thinking about them. For your book, when it comes to your book marketing, your goal, of course, is to reach that primary audience (the audience that you have defined when you've done all of your market research). When it comes to reaching that primary audience, you need to think about secondary audiences for your book. And what Jodi means by that are those people who are a bridge between you and that primary audience that you've set. Jodi is giving you some examples in this episode of who those secondary audiences might be AND how you can bridge the gap from your secondary to your primary audience. Head here for the full transcript.
Which is better, to invest in a major market or in a secondary? Join Pat and learn 3 reasons to invest in a major market, and three other reasons to invest in a secondary market.As always you can email Pat at Pat@MaraPoling.com
Rick Stroud and Steve Versnick on the mounting injuries in the Buccaneers secondary where it looks like 1 starter will be available on Sunday vs. the Dolphins. Plus where the Bucs stand after 4 games and why things aren't so bad despite not playing well the last 2 weeks. Also the Red Sox host the Yankees tonight with the winner taking on the Rays so who would you rather play? See acast.com/privacy for privacy and opt-out information.
In hour 1 of The Herd, Nick Wright gives his take on Belichick and his lack of belief in Mac Jones. Kicking FG was the deterrent... Cowboys look good! Nailing draft picks / Zeke had best game in 3 years. Tampa Bay may be exposed by this season due to injuries plaguing the secondary. Jimmy Johnson then joins the show to talk more on the future of the Cowboys this season. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com
Bourbon Secondary Market AKA BSM. For the right price you can have anything you want shipped to your door. Is it worth it? How does it work? Should it be shut down? In this episode we address all this and more! Please Share With Your Whiskey Friends, Subscribe, Review, Like, and Comment!
Scott and Jon react to the big news of the Bucs signing Richard Sherman for episode 416. They discuss how he can fit into this defense or if he even can at this point of his career. The guys also break down his press conference from today, plus the impact his veteran leadership and experience can help the rest of the secondary. Hear it all on the Pewter Report Podcast, energized by CELSIUS.
See omnystudio.com/listener for privacy information.
Ask your financial planner and they will agree that long-term real estate is almost always a good investment as long as the timing is right for you. Even in California where average home prices are notoriously high can real estate be a sound investment; you just need to be more cautious of the type of investment you make. While primary residences are still a hot commodity up and down the state, the pockets of investment areas are quickly shriveling up. Are there any decent areas left to invest in inside California or are those days already behind us? Joe Cucchiara explains why he believes the opportunity for investible non-owner-occupied properties has come and passed in California. To learn more, simply visit www.RERadioLive.com. All the information in this podcast is broadcast in good faith and for general information purpose only. We do not make any warranties about the completeness, reliability and accuracy of this information. Any action you take upon the information on our website is strictly at your own risk. We will not be liable for any losses and damages in connection with the use of associated information. www.reradiolive.com All Rights Reserved. Copyright 2015. Joe Cucchiara MLO 273084 This is not a commitment to lend. Our team fully supports the principles of the Fair Housing Act and the Equal Opportunity Act. For more information, please visit: http://portal.hud.gov/.
On this episode of the East Meets West Hunt podcast, Beau Martonik is joined by Jake Bush. Jake currently resides in southern Ohio and is known for capitalizing on some giant big woods bucks in the early season. We discuss the story of his mammoth 2019 Ohio buck, scouting plans for early season, secondary food sources, wind mapping, thermals and hunting hub systems. Topics: Jake's background and story Story of his mammoth 2019 buck Scouting plan for early season Secondary food sources Wind mapping and thermals Hunting hub systems Resources: Instagram: @eastmeetswesthunt @beau.martonik @jake_bush_solo Facebook: East Meets West Outdoors https://www.eastmeetswesthunt.com/ YouTube: Beau Martonik - https://www.youtube.com/channel/UCQJon93sYfu9HUMKpCMps3w Shop new apparel! https://www.eastmeetswesthunt.com/shop Amazon Influencer Page https://www.amazon.com/shop/beau.martonik Partners: Spartan Forge Forged in combat and tailored for hunters, Spartan Forge stands at the nexus of Machine Learning and White-tailed Deer hunting to deliver truly intuitive and science based products that save the hunter time spent scouting, planning and executing their hunts. Check out the Outfitter for deer movement predictions based on millions of data points for your area! Save 25% with coupon code eastmeetswest www.spartanforge.ai GoWild GoWild is a free social community built by hunters, for hunters. Use the code EASTMEETSWEST to save 10% off of all hunting gear on the website. https://timetogowild.com/share/eastmeetswest Heather's Choice Healthy, great tasting, dehydrated meals for the backcountry. Use code eastmeetswest to get free shipping on ALL orders. http://lddy.no/7og2 Maven Optics Top quality binoculars, spotting scopes and rifle scopes for your hunts from east to west. Use the code eastmeetswest-gift get a free gift with your next order! https://mavenbuilt.com/ MTN OPS MTN OPS is the leader in providing science based supplements to help you train inside and conquer more outside. Use the code BEAUFREESHIP for free shipping on all orders. https://glnk.io/mw0/beaumartonik TETHRD The Tethrd Team has created the ultimate tree saddle hunting setup. The Phantom Saddle and Predator Platform system is truly the culmination of ideas & input from thousands of dedicated tree saddle hunting fanatics around the world. https://tethrdnation.com/
Hosts Peter Kennedy and Pat Boyle recap the biggest matchups in week 3 including Chargers v Chiefs, Buccs v Rams, & Packers v 49ers. Do the Chiefs have real problems on their hands or are the Chargers just legit? Are the Rams the best team in the NFL? Buccs two glaring weaknesses, Run Game & Secondary, cost them in week 3 - will it continue to do so? The Packers came out firing but the 49ers nearly completed the come back. Is Aaron Rodgers 'back'? Plus, whos the worst franchise the Giants or Jets? The last 5 seasons may show us the answer is simply yes... Lastly, we go over No Regrets - our segment recapping our week of football takes, picks, and thoughts bouncing around the league to decide if we made bad calls or end up regretting nothing. Jets, Vikings, Ravens, Bills, Overs, Patriots, and more. @SubwaySportsTalk on IG and Tik Tok and @SubwaySportsTlk on twitter.
Gregg Bell of the Tacoma News Tribune joins Dave Softy Mahler and Dick Fain to discuss the Seahawks loss in Minnesota to the Vikings including the cornerback coverage schemes that DJ Reed and Tre Flowers are playing, the offensive issues in the second half and injury concerns on that side of the ball, Russell Wilson's running decisions, and how much trouble the team is in.
Injuries to Jessie Bates and Chidobe Awuzie have made the secondary thin, we get you notes from theJackson Carman rewatch, and discuss the trap game potential as heavy favorites in Week 4. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Nathan King is joined by former Auburn cornerback Jerraud Powers to break down Auburn's secondary from the Penn State game, how the Tigers will rebound, his thoughts on Bryan Harsin and more. Learn more about your ad choices. Visit megaphone.fm/adchoices
The first threat you see might not be the only threat you deal with.Unfortunately, military personnel, police officers, and concealed carry holders have been killed by secondary attacks that follow the initial attack they sought to deal with.In the episode we cover:What are primary and secondary attacks?Is this really a concern for CCW's?How do we train to protect ourselves against it?And more!Also, we take your questions:Should you change your EDC in response to weather and other changes?Semi-automatic vs. Revolver: Which is better?Ear Pro Selection: foam vs. muffsIt's all inside this episode of Pearl Snap Tactical!If you would like to support this podcast, please consider giving us a boost at:https://www.buymeacoffee.com/pearlsnapLink up with us:Website: www.BarritusDefense.comInstagram: https://www.instagram.com/thebarritus/Facebook: https://www.facebook.com/TheBarritus/Support the show (https://www.buymeacoffee.com/pearlsnap)
On this episode we discuss how the movie Let it Ride is the original speculation meme - long before Wall Street Bets was cool. We talk about why Greg's panicked about fires. And of course, we talk markets – finding those markets where the secondary market can be bigger than the primary market. How this is all leading to the fractionalizing of shares; and the eventual need for a regulatory framework. We close with the figurative fires of how much is happening around consumer and business behavior, particularly post COVID, and Greg's search for great teams in what he calls the “founder-market fit” Guest - Greg Bettinelli, Partner at Upfront Ventures howardlindzon.com, upfront.com Twitter: @howardlindzon, @gregbettinelli, @upfrontvc, @knutjensen linkedin.com/in/gregbettinelli #fintech #invest #investment #venturecapital #stockmarket #finance
Welcome to the Beared Down YT Channel! We are a multimedia brand devoted to all things Chicago Bears. We are excited to bring you fans Bears news, opinions, podcasts, and more!-2021-22 Season Partners MyBookie: Head to https://mybookie.ag today and use our promo code “BD” and instantly receive double your first deposit, that's double your funds, to double your winnings. Bet anything, anytime, and anywhere with MyBookie this NFL season! -Today (E. 251), we are back with another episode of the Beared Down podcast! The boys are back sharing their three key matchups in Bears vs. Browns! Can Justin Fields dice up a spotty Browns secondary? Can the Bears be the first team to put a stop to Nick Chubb? Tune in to hear Chris and Parth share the most important positional matchups in Week 3! -For more content from the crew including articles, opinions, and more, head to BearedDown.com
The Chargers lost to the Dallas Cowboys on Sunday and the guys breakdown all the important storylines from the Chargers first victory including: · The refs/penalties · Was the Chargers offense that bad? · Kyzir White's stock is up and Kenneth Murray's stock is down · The secondary has been the unsung heroes · Getting the ground game going · Mike Williams expanded role · The red zone inefficiency Plus, they also share what they want to takeback or apologize for from AFTER HOURS. Learn more about your ad choices. Visit podcastchoices.com/adchoices
James Yarcho and David Harrison host the top-ranked podcast on the Apple Podcast charts focused on the Tampa Bay Buccaneers and their pursuit for another Super Bowl title in the 2021-2022 NFL Season; voted by fans and listeners as the best Buccaneers focused podcast two years in a row! It's WTSP Wednesday and you know what that means - James is joined by WTSP's Evan Closky to get his thoughts on the win over the Falcons and they begin their preview of the upcoming contest against the Los Angeles Rams. Evan and James also discuss the possible addition of Richard Sherman and what the corresponding roster move could be, but they also respond to a listener call that proposes maybe the Buccaneers should look to Jacksonville and their cornerback C.J. Henderson for the answer in the secondary. Be sure to check out Evan's coverage of all things Tampa Bay sports at WTSP.com Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Manscaped Fellas, don't gamble on shaving your balls with the wrong tools! Choose MANSCAPED™, Your Balls Will Thank You™! Get 20% off + free shipping with the code LOCKEDON at manscaped.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Two weeks into the season, the Chicago Bears have a better sense of how their weaknesses are coming along. Locked on Bears host Lorin Cox checks in on the offensive line progress, struggles for a young secondary and too many penalties. Subscribe to Locked On Bears on YouTube: https://www.youtube.com/channel/UCXCnRo-iwMsS4iC1SobeGHA Follow @LockedOnBears on Twitter: https://twitter.com/lockedonbears Like Locked on Bears on Facebook: https://www.facebook.com/LockedOnBears Support Us By Supporting Our Sponsors! Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Manscaped Fellas, don't gamble on shaving your balls with the wrong tools! Choose MANSCAPED™, Your Balls Will Thank You™! Get 20% off + free shipping with the code LOCKEDON at manscaped.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices
For nearly 20 months, COVID-19 has been top of mind. The pandemic, however, has created another troubling development. People are now putting off addressing general health concerns that could be better managed by routine check ups or general well visits. To curb this trend, Philadelphia family practitioner Dr. Vicki Bralow says simply pick up your phone, call your doctor, and check in. She joins KYW Newsradio's Matt Leon on In Depth. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Alex and Anthony discuss why the Giants might not being using Kadarius Toney, hi backlash to the media, and the defense's struggles through two weeks. See omnystudio.com/listener for privacy information.
Heeeeey homebrewer! Welcome back to another fun-filled episode of our Homebrew Happy Hour podcast… the podcast where we answer all of your home brewing questions and discuss anything related to craft beer! A SUBTLE REMINDER: If you appreciate the things we do here at Homebrew Happy Hour, consider joining our Trub Club! Not only will you […]
The Tennessee Titans let down Seahawks fans this past weekend by losing at home to the Arizona Cardinals. The Titans offensive line did not account for Chandler Jones nearly well enough in their game and he was able to dominate--leading to an early defensive score. There are questions on whether or not the Titans offensive line will be able to protect Tannehill going forward and block well enough so Derrick Henry isn't getting hit in the backfield. One defense, the secondary is almost made up of entirely new names and could offer DK Metcalf and Tyler Lockett the ability to have a big game on Sunday. Subscribe to the Field Gulls Podcast via: Apple Podcasts | Google Podcasts | Spotify |Overcast | Pocket Casts | Stitcher | Castbox | Subscribe on Android | PlayerFM | RSS Help support the show with a yearly or recurring monthly donation: patreon.com/flock Learn more about your ad choices. Visit podcastchoices.com/adchoices
The Dolphins announced on Tuesday that Raekwon Davis will go to the IR. Damn. But here's how Miami can make due until he's back. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Chris Carter, NFL and NCAAF analyst, is joined by Tony Serino to analyze the Steelers' defensive backs and what went right about their performance against the Bills Sunday. The guys dig into the snap counts and film to see what made this group look deeper than what we expected early in the season. They'll also talk about Mike Tomlin's coaching, halftime adjustments and the state of the AFC North. Follow Chris Carter on Twitter: @CarterCritiques. Theme music is 'Soul Kick' by Ceddy P, and 'Too Easy' by Nerdboy. Both from their label Renaissance Music. Find more from their label here. This show is part of the Locked on Podcast Network. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Rick Stroud and Steve Versnick answer your mailbag questions about the Bucs 31-29 win over the Cowboys, should there be concern over the running backs and secondary, why OJ Howard didn't play in the 2nd half, will Urban Meyer succeed as an NFL Coach, is this new Jameis Winston here to stay, are Clemson and Ohio State already about of the College Football Playoff, what concerns should we have about the Rays pitching staff, who wins between Florida State and USF and who gets a new stadium first, the Rays or USF. See acast.com/privacy for privacy and opt-out information.
On today's episode of Locked On Colts, Evan is joined by Stampede Blue's Stephen Reed to recap the Indianapolis Colts' 28-16 loss to the Seattle Seahawks. Wheat were the biggest takeaways from this one? Indy's offensive line and defensive backs were major disappointments, while Carson Wentz looked very in control of Frank Reich's offense once more. We talk the game from every angle in a recap format, so stay tuned for more analysis plus previewing their Week 2 matchup against the Los Angeles Rams throughout this week! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dave Caban overviews Week 1 WR/TE vs CB/S matchups... The RotoViz Fantasy Football Show is powered by RotoViz Radio. HOSTS Dave Caban (@davecabanff) – RotoViz Co-Owner Curtis Patrick (@CPatricknfl) – RotoViz Co-Owner The RotoViz Fantasy Football Show A RotoViz podcast covering all things fantasy football, hosted by Dave Caban and Curtis Patrick SPONSORS RotoViz- RotoViz Radio listeners can save 10% off of a 1-year RotoViz subscription at RotoViz.com/podcast or by applying the discount code 'rvradio2021' at checkout. SHOW NOTES Email: RotoVizFFshow@gmail.com Voice Mail: (978)-615-9214 Learn more about your ad choices. Visit podcastchoices.com/adchoices
Ohio State head coach Ryan Day declined to comment on the status of defensive backs Josh Proctor, Sevyn Banks and Cameron Brown when meeting with the media on Tuesday. We know all three players are dealing with injuries, but are they severe? How concerned should we be about this situation? Matt Baxendell joins Dave Biddle to discuss that, plus: * Thoughts on the Buckeyes' big game against visiting Oregon this Saturday. * Regarding the defensive issues against Minnesota last week, what was the biggest factor: OSU's personnel, OSU's coaching, or Minnesota being good? * Who will lead the team in rushing this season? Miyan Williams or TreVeyon Henderson? All of that and more is coming your way on the Wednesday 5ish. Learn more about your ad choices. Visit megaphone.fm/adchoices