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Matt Crawford speaks with author Dr. Neal Baer about his book, The Promise and the Peril of CRISPR. Scientists and genetic engineers are becoming increasingly adept at editing the human genome. How far can—and should—they go in editing future generations? In The Promise and Peril of CRISPR, editor Neal Baer brings together a timely collection of essays by influential bioethicists, philosophers, and geneticists to explore the moral, ethical, and policy challenges posed by CRISPR technology. We are at a technological and ethical crossroads in grappling with the impacts of genetic editing. Gene-editing technology holds the promise of curing more than 7,000 known genetic diseases. Yet with that promise comes the peril of using CRISPR to edit the human genome, which could not only lead to manipulating human evolution, but also to creating and releasing pathogens capable of wreaking havoc on human, animal, and plant life. Although CRISPR has already cured several genetic diseases, it could also be used to design biological weapons or to edit the embryos of people who can afford to purchase genetic "enhancements" for their children. What role can and should the public play in discussing the far-reaching implications of gene editing? What oversights should be put in place to prevent a rogue scientist from engineering another baby – as was recently done with twins in China? Essay contributors offer informed predictions and guidelines for how the uses of CRISPR today will affect life in the future. Decisions we make now may have unpredictable consequences for future generations. For anyone concerned about the uses and potential abuses of gene editing, these essays provide a critical and comprehensive discussion of the central issues surrounding CRISPR technology. Contributors: Florence Ashley, R. Alta Charo, Marcy Darnovsky, Kevin Doxzen, Rosemarie Garland-Thomson, Gigi Kwik Gronvall, Jodi Halpern, Katie Hasson, Andrew C. Heinrich, Jacqueline Humphries, J. Benjamin Hurlbut, Ellen D. Jorgensen, Peter F. R. Mills, Carol Padden, Marcus Schultz-Bergin, Robert Sparrow, Sandra Sufian, Krystal Tsosie, Ethan Weiss, Rachel M. West
Guest: ✨ Dr. Neal Baer, Co-Director, Master's Degree Program in Media, Medicine, and Health, Harvard Medical SchoolOn LinkedIn | https://www.linkedin.com/in/neal-baer/On Twitter | https://x.com/NealBaerOn Facebook | https://www.facebook.com/neal.baer.75/On Instagram | https://www.instagram.com/nealbaer/____________________________Host: Marco Ciappelli, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining Society PodcastOn ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/marco-ciappelli_____________________________This Episode's SponsorsBlackCloak
In 2018, Chinese scientist He Jianku sent shockwaves through the world's medical and scientific world when he claimed to have made two children immune to HIV using a powerful gene-editing technology called “CRISPR”. After a three-year prison sentence, Jianku is back in the lab, but should he be experimenting with human genes? Ray Suarez talks with Dr. Alta Charo, the Warren P. Knowles Professor Emerita of Law and Bioethics at the University of Wisconsin at Madison, about the ethics of CRISPR, and the opportunities and risks of the technology. Guest: Dr. Alta Charo, the Warren P. Knowles Professor Emerita of Law and Bioethics at the University of Wisconsin at Madison Host: Ray Suarez, host of World Affairs If you appreciate this episode and want to support the work we do, please consider making a donation to World Affairs. We cannot do this work without your help. Thank you.
R. Alta Charo is a professor emerita of law and bioethics at the University of Wisconsin at Madison. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. R.A. Charo. Back to the Future in Alabama. N Engl J Med 2024;390:1253-1255.
A lawyer and bioethicist by training, Alta Charo has decades of experience in helping to formulate and inform science policy on new and emerging technologies, including stem cells, cloning, CRISPR, and chimeras. The Warren P. Knowles Professor Emerita of Law and Bioethics at the University of Wisconsin at Madison, she served on President Clinton's National Bioethics Advisory Commission, was a member of President Obama's transition team, was an advisor for the Food and Drug Administration, and served on more than a dozen study committees for the National Academies of Sciences, Engineering, and Medicine. In the fourth episode of our Science Policy IRL series, Alta joins Issues contributing editor Molly Galvin to explore how science policy can and does impact people's lives in real and profound ways. She also describes what it's like to be one of the only non-scientists at the science policy table, how helping a close friend who died of ALS continues to inspire her work, and why science policy can help us become techno optimists. Is there something about science policy you'd like us to explore? Let us know by emailing us at podcast@issues.org, or by tagging us on social media with the hashtag #SciencePolicyIRL. Resources: National Academies Collection on Stem Cell Research Institute of Medicine. 2005. Review of the HIVNET 012 Perinatal HIV Prevention Study National Academies of Sciences, Engineering, and Medicine and National Academy of Medicine. 2023. Toward Equitable Innovation in Health and Medicine: A Framework National Academies of Sciences, Engineering, and Medicine. 2017. Human Genome Editing: Science, Ethics, and Governance The Issues Interview: Alta Charo Previous episodes of Science Policy IRL Zach Pirtle Explores Ethics for Mars Landings Apurva Dave Builds Connections Between National Security and Climate Quinn Spadola Develops Nanotechnology With Soft Power
Grey Mirror: MIT Media Lab’s Digital Currency Initiative on Technology, Society, and Ethics
Alta is a Professor Emerita of Law and Bioethics at the University of Wisconsin at Madison. She's been focused on bioethics for a few decades across government, academia, and industry. She was featured in the Netflix documentary on CRISPR, Human Nature. https://law.wisc.edu/profiles/racharo https://en.wikipedia.org/wiki/Alta_Charo https://www.patreon.com/rhyslindmark https://www.roote.co/
Prof. R. Alta Charo is a professor emerita of law and bioethics at the University of Wisconsin at Madison. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. R.A. Charo. Vigilante Injustice — Deputizing and Weaponizing the Public to Stop Abortions. N Engl J Med 2021;385:1441-1443.
An interview with R. Alta Charo, the Warren P. Knowles Professor of Law and Bioethics at the University of Wisconsin. Prof. Charo discusses the development of COVID-19 treatments and vaccines and the procedures and legal issues that surround each.
Alta CharoShe recommends checking out the documentary “Human Nature,” in which she appears.Learn about CRISPR gene editingRevive & Restore, the organization working on “genetic rescue” of endangered and extinct species.The controversy over He Jiankui’s genetic modification of human embryosVisit CASBS on the webVisit CASBS on TwitterCASBS staff member Jason Gonzales read this episode's opening line. Woohoo!
Recognizing that CRISPR and other genome editing technologies have rapidly outpaced standard textbook knowledge, Lab Out Loud reached out to R. Alta Charo, professor of Law and Bioethics at the University of Wisconsin-Madison. Alta joins co-hosts Brian Bartel and Dale Basler to talk about the ethics of CRISPR and genome editing, what current students and parents might need to know about biotechnological advances in genome editing, and the increasing importance of careers at the intersection of science, policy and law. Show notes at: https://laboutloud.com/2018/09/episode-191-bioethics-of-crispr/
Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
To paraphrase Ian Malcolm in Jurassic Park, scientists tend to focus on whether they can do something, not whether they should. Questions of what we should do tend to wander away from the pristine beauty of science into the messy worlds of ethics and the law. But with the ongoing revolutions in biology, we can’t avoid facing up to some difficult should-questions. Alta Charo is a world expert in a gamut of these issues, working as a law professor and government official specializing in bioethics. We hit all the big questions: designer babies, birth control, abortion, religious exemptions, stem cells, end of life care, and more. This episode will give you the context necessary to think about a host of looming questions from a legal as well as a moral perspective. Alta Charo is currently the Warren P. Knowles Professor of Law and Bioethics at the University of Wisconsin–Madison. She earned a B.A. in Biology from Harvard, and went on to receive her J.D. from Columbia University. Charo served as a bioethics advisor on the Obama Administration transition team, as well as working as a senior policy advisor at the Food and Drug Administration. She has been a Fulbright Scholar, is a member of the National Academy of Medicine, and was awarded the Chancellor’s Distinguished Teaching Award at UW-Madison.
Prof. R. Alta Charo is a professor of law and bioethics at the University of Wisconsin at Madison. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. R.A. Charo. Alternative Science and Human Reproduction. N Engl J Med 2017;377:309-11.
Earlier this month the National Academy of Sciences and the National Academy of Medicine issued a report that considered the scientific, ethical, and governance issues surrounding human genome editing. The report comes as new gene editing technologies have reduced the cost and increased the ease of manipulating the human genome. We spoke to Alta Charo, co-chair of the study committee that wrote the report and professor of Law and Bioethics at University of Wisconsin-Madison, about the study, the potential for this science, and where the committee thought limits should be imposed.
R. Alta Charo is a professor of law and bioethics at the University of Wisconsin at Madison. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. R.A. Charo. Whole Women’s Victory - or Not? N Engl J Med 2016;375:809-11.
Prof. R. Alta Charo is a professor of law and bioethics at the University of Wisconsin-Madison. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. R.A. Charo. On the Road (to a Cure?) - Stem-Cell Tourism and Lessons for Gene Editing. N Engl J Med 2016;374:901-3.
Prof. R. Alta Charo is a Professor of Law and Bioethics at the University of Wisconsin. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. R.A. Charo. Physicians and the (Woman's) Body Politic. N Engl J Med 2014;370:193-5.
Alta Charo from the University of Wisconsin discusses her recent work with Hank Greely.
Prof. R. Alta Charo is a professor of law and bioethics at the University of Wisconsin at Madison. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. K. White, D. Grossman, K. Hopkins, and J.E. Potter. Cutting Family Planning in Texas. N Engl J Med 2012;367:1179-81.