Podcasts about Human reproduction

Procreative biological processes of humanity

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Human reproduction

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Best podcasts about Human reproduction

Latest podcast episodes about Human reproduction

Get Pregnant Naturally
Told It Was Unexplained? 9 Tests Your Miscarriage Workup Skipped

Get Pregnant Naturally

Play Episode Listen Later Jun 22, 2026 18:45


You were told to try again. Maybe you were told it was bad luck, or to wait until it happened a third time before anyone would look. Here is what changed this year. In 2026, the American Society for Reproductive Medicine updated its definition of recurrent pregnancy loss for the first time since 2012. Two losses now meet the definition, not three, and a positive test that ended early counts. The old number kept women waiting for a third loss before the investigation even started. Here is the part no one tells you. Meeting the definition gets you a workup. It does not guarantee the workup is complete. After two or more losses, up to half of couples are told the same word. Unexplained. The losses are real. What gets called a complete workup is the question. This episode is the 9 specific things we most often find that are rarely checked before a woman is told her losses were unexplained or simply bad luck. Pull it up. Take notes. Bring it to your next appointment. The 9 patterns: Thyroid, the full panel and antibodies, not just TSH Antiphospholipid antibodies, tested correctly Chronic endometritis The reproductive microbiome, vaginal and seminal The gut, hidden gluten, and inflammation Sperm DNA fragmentation The male partner's full bloodwork Blood sugar and metabolic patterns The nervous system and progesterone These are the areas that sit outside a standard miscarriage workup. A 2012 meta-analysis in Human Reproduction, pooling sixteen studies and nearly three thousand couples, found miscarriage rates rose with sperm DNA damage, with about twice the relative risk. Unexplained rarely means there is nothing to find. It usually means the search stopped at the karyotype, one antiphospholipid test, the anatomy, and a TSH. For the full breakdown of every pattern, read the companion article, Recurrent Pregnancy Loss: The Functional Fertility Approach, at https://fabfertile.com/blogs/learn/recurrent-pregnancy-loss WHAT YOUR CLINIC MISSED The companion guide walks through all 9 of these patterns in more detail, so you can take it to your next appointment and ask the questions. Email hello@fabfertile.ca, subject line MISSED, and we will send you the guide. FUNCTIONAL FERTILITY SECOND OPINION A free 45-minute call where I review your labs, your history, your losses, and your partner's results with you. You leave knowing what your biology has been telling you and what your next decision could be. Email hello@fabfertile.ca, subject line FERTILE, or book here. ABOUT THE HOST I'm Sarah Clark, founder of Fab Fertile and host of Get Pregnant Naturally, a podcast with over one million downloads. My functional fertility team works with couples navigating low AMH and failed IVF, reviewing functional lab results, gut microbiome, food sensitivity, vaginal microbiome, nutrigenomics, HTMA, DUTCH, toxin testing, and bloodwork alongside nervous system work, to help identify patterns that may not have been considered. We work alongside your medical team, not instead of them. Sarah Clark, founder of Fab Fertile, host of Get Pregnant Naturally (1M+ downloads), and author of Fabulously Fertile. If this episode helped, leave a review on Apple Podcasts. It is how other women find this work. TIMESTAMPS 00:00 What "Unexplained" Means and What the 2026 Guideline Changed 01:30 Who's Reviewing Your Case at Fab Fertile 04:00 Thyroid: The Full Panel, Not Just TSH 05:50 Antiphospholipid Antibodies, Tested Correctly 06:30 Chronic Endometritis 07:30 The Reproductive Microbiome 08:30 The Gut, Hidden Gluten, and Inflammation 10:30 What Your Clinic Missed Guide 11:00 Sperm DNA Fragmentation 12:30 The Male Partner's Full Bloodwork 13:50 Blood Sugar and Metabolic Patterns 15:20 The Nervous System and Progesterone 16:30 What "Unexplained" Really Means 17:20 The Functional Fertility Second Opinion

Everyday Wellness
Ep. 605 "What Happens When You Stop the Pill in Midlife?" | Oral Contraceptives, Menopause, Perimenopause, Hormones

Everyday Wellness

Play Episode Listen Later Jun 11, 2026 37:52


Welcome to the latest Midlife Minute. Today, I'm taking a closer look at oral contraceptive use in perimenopause and menopause, exploring how oral contraceptives work, how they suppress or blunt perimenopausal and menopausal symptoms, alter hormone signaling and testing, what women may experience when they stop taking them, and why the gut microbiome is an essential part of the conversation. IN THIS EPISODE, YOU WILL LEARN: How oral contraceptives suppress certain key signaling hormones, making it difficult to assess women's menopausal status accurately What women may experience when transitioning off oral contraceptives How long-term oral contraceptive use can alter gut microbial function and inflammatory pathways The association between long-term oral contraceptive use and nutrient depletion Why the standard reproductive hormone markers used to assess menopause (especially FSH/LH) are unreliable while on the pill How the microbiome changes that occur as women age may compound the effects of previous oral contraceptive use Helpful dietary, microbiome, and lifestyle strategies to support women navigating the post-pill transition Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Resources:  Sitruk-Ware R, Nath A. Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills. Best Practice and Research: Clinical Endocrinology and Metabolism. 2013;27(1):13–24. doi:10.1016/j.beem.2012.09.004 Schaffir J, Worly BL, Gur TL. Combined hormonal contraception and its effects on mood: a critical review. European Journal of Contraception and Reproductive Health Care. 2016;21(5):347–355. doi:10.1080/13625187.2016.1217327 Panzer C, Wise S, Fantini G, Kang D, Munarriz R, Guay A, Goldstein I. Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: a retrospective study in women with sexual dysfunction. Journal of Sexual Medicine. 2006;3(1):104–113. doi:10.1111/j.1743-6109.2005.00198.x Palmery M, Saraceno A, Vaiarelli A, Carlomagno G. Oral contraceptives and changes in nutritional requirements. European Review for Medical and Pharmacological Sciences. 2013;17(13):1804–1813. PMID:23852908 Khalili H, Higuchi LM, Ananthakrishnan AN, Richter JM, Feskanich D, Fuchs CS, Chan AT. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut. 2013;62(8):1153–1159. doi:10.1136/gutjnl-2012-302362 Flores R, Shi J, Fuhrman B, Xu X, Veenstra TD, Gail MH, Gajer P, Ravel J, Goedert JJ. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. Journal of Translational Medicine. 2012;10:253. doi:10.1186/1479-5876-10-253 Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: physiological and clinical implications. Maturitas. 2017;103:45–53. doi:10.1016/j.maturitas.2017.06.025 Hua X, Cao Y, Morgan DM, Miller K, Chin SM, Bellavance D, Khalili H. Longitudinal analysis of the impact of oral contraceptive use on the gut microbiome. Journal of Medical Microbiology. 2022;71(4):001512. doi:10.1099/jmm.0.001512 Mihajlovic J, Leutner M, Hausmann B, Kohl G, Schwarz J, et al. Combined hormonal contraceptives are associated with minor changes in composition and diversity in gut microbiota of healthy women. Environmental Microbiology. 2021;23(6):3037–3047. doi:10.1111/1462-2920.15461 Seelig MS. Increased magnesium need with use of combined oestrogen and calcium supplementation. Magnesium Research. 1990;3(3):197–215. PMID:2133742 Donders GGG, Bellen G, Mendling W. Management of recurrent vulvo-vaginal candidosis as a chronic illness. Gynecologic and Obstetric Investigation. 2010;70(4):306–321. doi:10.1159/000314022 Krog MC, Hugerth LW, Fransson E, et al. The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle. Human Reproduction. 2022;37(7):1525–1543. doi:10.1093/humrep/deac094

Misconceptions
71. Envisioning What's Next: When It's Time to End Infertility Treatment

Misconceptions

Play Episode Listen Later May 29, 2026 51:12


Julia T. Woodward, Ph.D. is a Professor in the Departments of Psychiatry & Behavioral Sciences and Obstetrics & Gynecology in the Duke University Health System. She has directed the Patient Support Program at the Duke Fertility Center for over 20 years. Clinically, she specializes in working with patients facing infertility, pregnancy loss, third-party reproduction, fertility preservation, and perinatal mood disorders. She trains Clinical Psychology PhD students, Predoctoral Interns, and Postdoctoral Fellows as well as REI Fellows and OBGYN residents in the psychosocial aspects of reproductive medicine. She has held multiple committee leadership positions in the Mental Health Professional Group of the American Society for Reproductive Medicine, is the current Chair of the Scientific Development Committee and previously served on the Executive Council for the Society for Assisted Reproductive Technology (SART). She serves as an Associate Editor for Human Reproduction. She publishes regularly and lectures internationally on the psychosocial aspects of reproductive medicine, integration of mental health services into fertility care teams, and later-life parenting. CONNECT WITH DVORA ENTIN: Website: https://www.dvoraentin.com/ Instagram: https://www.instagram.com/dvoraentin YouTube: https://www.youtube.com/@misconceptionspodcast  

Inside Reproductive Health Podcast
283 Proof of Concept. IVF Lab Automation. Drs. Jason Barritt & Jacques Cohen

Inside Reproductive Health Podcast

Play Episode Listen Later Mar 29, 2026 56:32


The results are in: 5 healthy babies born, 64.3% fertilization rate, zero eggs damaged across hundreds of oocytes.Lab automation in IVF is no longer theoretical, it's been proven.Chief Scientific Officers Jason Barritt of Kindbody and Jacques Cohen of Conceivable Life Sciences join the episode to discuss a recent study published in Human Reproduction examining AURA, the robotic lab system developed by Conceivable Life Sciences.We dive into:What “proof of concept” actually means in IVF lab automationWhy this study matters (And where it falls short of current standards)The role of automation as a testing ground for new lab technologiesWhat a fully automated IVF lab could unlockWhether “hub and spoke” models in fertility have been misunderstood (and what they could actually become)If automation continues to progress, the scale of what's possible in fertility care may look very different than it does today.

Talking Away the Taboo with Dr. Aimee Baron
197. Carrying for Family: A Cousin's Gift of Surrogacy with Andrea Syrtash, Elana Syrtash-Ochs, and Aliza Abrams Konig

Talking Away the Taboo with Dr. Aimee Baron

Play Episode Listen Later Mar 19, 2026 44:01


In this episode, IWSTHAB's Surrogacy Support Consultant Aliza Abrams Konig sits down with Andrea Syrtash, a relationship expert and founder of Pregnantish, and her cousin Elana Syrtash-Ochs, an early childhood educator and enentrepreneur, to discuss their shared journey through gestational surrogacy. The conversation explores the profound emotional shift that occurs when a family member steps in after years of infertility, loss, and the heartbreak of being ghosted by a previous surrogate. Andrea reflects on her winding path to parenthood, marked by endometriosis, multiple miscarriages, and the eventual realization that she needed a gestational carrier. After a devastating experience with a surrogate who disappeared mid-process, Elana moved the family toward healing by offering to carry Andrea's baby herself. Together, they navigate the unique dynamics of intrafamily surrogacy, discussing how they set healthy boundaries, managed the curiosity of young children, and even educated hospital staff on how to respectfully handle a surrogacy birth. Their story is a powerful testament to trust, "beshert" timing, and the strength of family bonds. If you are navigating the complexities of surrogacy this episode offers a roadmap of honesty and hope. View additional surrogacy resources: here More about Andrea Syrtash: Andrea Syrtash is a relationships and sexual health author, fertility advocate, and founder of Pregnantish—the first media platform exclusively dedicated to helping people navigate fertility treatments and infertility. She is also the founder of the World Fertility Awards, the first global, consumer-facing event recognizing and celebrating assisted reproductive technology and the future of family. Andrea is passionate about supporting the 1 in 6 diagnosed with infertility worldwide, as well as the many more who lack access to the care and information they need to build their families. She is the author of multiple books published by Penguin Random House, including He's Just Not Your Type (And That's a Good Thing) and Cheat on Your Husband (With Your Husband) She has hosted television programs for Oprah's OWN (Canada), Discovery Network, and Fox, and regularly appears as a guest expert in global media including Good Morning America, Women's Health, The Times of India, Forbes Brazil and NHK Japan. Andrea hosts the Pregnantish podcast, which explores the extraordinary lengths people go to create their families through science and was recently named a New York Times–recommended listen. As Editor-in-Chief of pregnantish, Andrea authored and helped lead one of the largest studies on fertility patient retention, "Why I Left My Fertility Clinic for Another ART Provider," published in Human Reproduction (2022). Originally from Toronto, Andrea lives in Brooklyn with her husband and daughter, who was born via gestational surrogacy after many years of fertility treatment. She remains deeply committed to breaking the stigma around infertility and elevating conversations about modern family-building. Connect with Andrea: - Check out Andrea's Instagram - Visit her website here - Send her an email More about Elana Syrtash-Ochs, M.Ed: Originally from Toronto, Canada, Elana (Syrtash) Ochs has been involved in children's programming for over 20 years. Elana is the owner and director of Kol Chaverim Preschool in Fair Lawn, NJ which was founded in 2012 as well as KC Kids Aftercare program at Yeshivat He'Atid, in Teaneck, NJ, founded in 2016. Elana also created Gan Yavneh Daycare and served as Yavneh Academy's Preschool Director and Manager for 3 years from its inception in 2017. Elana has several years of experience as an educator, preschool director, camp director and consulting director for programs all around NY & NJ. Elana ran her swim program, Morah Elana's Swim, in Englewood from 2012-2022 and was the Program Director & Host at Upscale Getaways Passover Program in Niagara Falls, Canada for several years as well. Elana graduated from Yeshiva University with a B.A. in English Literature, a Minor in Music and an A.A. in Judaic Studies. She also earned a dual Masters degree in Early Childhood Education and Special Education at Touro College, NY. Prior to working as a Preschool Director, Elana worked as an EMT in New York. She was also the Head Lifeguard at the camp run by the Hebrew Academy for Special Children (HASC) for 2 years. Elana was selected to join Teach for America in 2008 and served as a special educator and corps member in Harlem and the Bronx. Connect with Elana: - Check out Elana's Instagram and Facebook - Send her an email More about Aliza Abrams Konig, MSW: Aliza Abrams Konig is the Director of Student Leadership at Yeshiva University. Throughout Aliza's career, she has worked within areas of student life, team building, creating curricula, and Experiential Education. Earlier in Aliza's career she served as the YU Director of Alumni Engagement, Assistant Principal at Central, Yeshiva University High School for Girls, Director of Student Life at Stern College, and as the Director of Jewish Service Learning for the University. Aliza is a member of the inaugural Wexner Field Fellows program through the Wexner Foundation. As a sought-after consultant on surrogacy, Aliza is passionate about raising awareness around surrogacy in the Jewish community. She has spoken on podcasts, worldwide in synagogues, community centers, and schools about the contemporary Jewish family, dating, infertility, and surrogacy. Aliza holds a BA in Judaic Studies from Stern College, and a Master's in Social Work from the Wurzweiler School of Social Work and is now a doctoral candidate at Wurzweiler. Aliza, her husband Samuel, and their family live in Riverdale, New York, where they are very involved with their community, synagogue, and other local organizations. Connect with Aliza: - Set up a surrogacy consultation here - Contact her via email - Connect on Instagram Connect with us: -Check out our Website -Follow us on Instagram and send us a message -Watch our TikToks -Follow us on Facebook -Watch us on YouTube -Connect with us on LinkedIn

THIS IS REVOLUTION >podcast
EP. 847: IS HUMAN REPRODUCTION A POLITICAL ACT? ft. EVELINA JOHANSSON WILEN

THIS IS REVOLUTION >podcast

Play Episode Listen Later Feb 26, 2026 49:31


READ EVELINA'S ARTICLE IN JACOBIN HERE: https://jacobin.com/2026/01/birth-rates-children-pronatalism-gender?fbclid=IwY2xjawQKndtleHRuA2FlbQIxMABicmlkETJWZTNiYW9FS21sOUxWT3RXc3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHia0kX_t5tdZE7S92zJhMpKAnSPg6Meo6yMDcxB6ZMkg1Fs3x6mu9JZRf04P_aem_xjDp8eLRvImgXKjZ-ZJXtg Global fertility decline has made reproduction a site of reactionary family policies and moralized childlessness. But a healthy society would let people choose to have children or not without turning that choice into a moral adjudication.   Check out our new bi-weekly series, "The Crisis Papers" here: https://www.patreon.com/bitterlakepresents/shop   Thank you guys again for taking the time to check this out. We appreciate each and everyone of you. If you have the means, and you feel so inclined,   BECOME A PATRON! We're creating patron only programing, you'll get bonus content from many of the episodes, and you get MERCH!   Become a patron now https://www.patreon.com/join/BitterLakePresents?   Please also like, subscribe, and follow us on these platforms as well, (specially YouTube!)   THANKS Y'ALL   YouTube: https://www.youtube.com/channel/UCG9WtLyoP9QU8sxuIfxk3eg Facebook: https://www.facebook.com/Thisisrevolutionpodcast/ Twitter: @TIRShowOakland Instagram: @thisisrevolutionoakland   Substack: https://jmylesoftir.substack.com/.../the-money-will-roll...   Read Jason Myles in Current Affairs Magazine here: https://www.currentaffairs.org/.../donald-trump-is-a-pro... Read Jason Myles in Damage Magazine https://damagemag.com/2023/11/07/the-man-who-sold-the-world/

Dr. Chapa’s Clinical Pearls.
FDA's ENG Label Change: What To Know

Dr. Chapa’s Clinical Pearls.

Play Episode Listen Later Jan 23, 2026 12:45


Implanon (etonogestrel implant) first received FDA approval in 2006, followed by the improved, radiopaque version, Nexplanon, approved by the FDA in 2010, which is now the only contraceptive implant available in the U.S. It was originally FDA approved for a 3-year use duration, although peer reviewed clinical data had demonstrated efficacy through year 5. Now, as of January 2026, the FDA has formally agreed to extend the label for 5-year use. In this episode, we will review the clinical data that prompted the FDA's decision, based on a multicenter, single-arm, open-label study evaluating contraceptive efficacy and safety during years 4 and 5 of implant use.1. https://www.contemporaryobgyn.net/view/fda-approves-5-year-use-for-etonogestrel-implant-68-mg-contraceptive2. Organon announces US Food and Drug Administration approval of supplemental new drug application extending duration of use of NEXPLANON (etonogestrel implant) 68 mg Radiopaque. Organon. Press release. January 16, 2026. Accessed January 19, 2026. https://www.organon.com/news/organon-announces-us-food-and-drug-administration-approval-of-supplemental-new-drug-application-extending-duration-of-use-of-nexplanon-etonogestrel-implant-68-mg-radiopaque/3. Ali M, Akin A, Bahamondes L, et al. Extended Use Up to 5 Years of the Etonogestrel-Releasing Subdermal Contraceptive Implant: Comparison to Levonorgestrel-Releasing Subdermal Implant. Human Reproduction. 2016. 4. McNicholas C, Swor E, Wan L, Peipert JF. Prolonged Use of the Etonogestrel Implant and Levonorgestrel Intrauterine Device: 2 Years Beyond Food and Drug Administration-Approved Duration. American Journal of Obstetrics and Gynecology. 2017. 5. McNicholas C, Maddipati R, Zhao Q, Swor E, Peipert JF. Use of the Etonogestrel Implant and Levonorgestrel Intrauterine Device Beyond the U.S. Food and Drug Administration-Approved Duration. Obstetrics and Gynecology. 2015.

Dr. Brendan McCarthy
Progesterone: The Breakthrough Women Deserve

Dr. Brendan McCarthy

Play Episode Listen Later Dec 4, 2025 26:46


In today's episode, I'm opening the first chapter of what I believe is the most important series I've ever created — a deep dive into progesterone and why it became the heart of my medical practice. For more than 20 years, I've watched this “simple, humble hormone” transform women's lives in ways most conventional medicine overlooks. What started in two small treatment rooms has grown into a 25,000 sq ft facility, and the core of our success comes down to understanding progesterone's impact on the female brain, stress response, and emotional resilience. In this episode, I break down: Why progesterone is far more than a reproductive hormone How it regulates the female stress response (amygdala, hippocampus, prefrontal cortex) Why anxiety, insomnia, irritability, and emotional overwhelm often map directly to progesterone decline Why so many women feel “unraveled” in their 40s — and why it's not their fault The science behind oral vs. sublingual progesterone (and why I use troches) How conventional medicine often misses the root cause The importance of physicians showing their work, their data, and their citations The lived stories and clinical outcomes that changed how I practice medicine If you've ever felt dismissed, unseen, or told that your anxiety or mood changes are “just stress,” this episode is for you. This is the beginning of a 7-part series where I break down the neurobiology, endocrinology, testing, dosing, delivery methods, breast health, perimenopause, and more.   Citations: Brinton, Roberta Diaz, et al. “Neurosteroids and Brain Function.” Steroids, vol. 81, 2014, pp. 61–78. Epperson, C. Neill, et al. “New Insights into Perimenopausal Depression: A Neuroendocrine Vulnerability Framework.” The Lancet Psychiatry, vol. 9, no. 2, 2022, pp. 110–118. Frye, Cheryl A. “Neurosteroids—Endogenous Modulators of GABA_A Receptors.” Pharmacology & Therapeutics, vol. 116, no. 1, 2007, pp. 58–76. Genazzani, Andrea R., et al. “Progesterone, Stress, and the Brain.” Human Reproduction Update, vol. 16, no. 6, 2010, pp. 641–655. Meeker, John D., et al. “Environmental Endocrine Disruptors: Their Effects on Human Reproduction and Development.” Reproductive Toxicology, vol. 25, 2008, pp. 1–7. Mellon, Stanley H. “Neurosteroid Regulation of Central Nervous System Development.” Pharmacology & Therapeutics, vol. 116, 2007, pp. 107–124. Mizrahi, Romy, et al. “The Role of Allopregnanolone in Stress, Mood, and Trauma.” Neurobiology of Stress, vol. 11, 2019, 100198. Paul, Steven M., and Graziano Pinna. “Allopregnanolone: From Molecular Pathways to Therapeutic Applications.” Current Opinion in Neurobiology, vol. 48, 2018, pp. 90–96. Pluchino, Nicoletta, et al. “Progesterone and Allopregnanolone: Effects on the Central Nervous System in the Luteal Phase and in Perimenopause.” Gynecological Endocrinology, vol. 36, no. 6, 2020, pp. 441–445. Rasgon, Natalie L., et al. “Perimenopausal Changes in the Brain and Mood: A Review.” Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 4, 2022, pp. 1120–1134. Reddy, Doodipala Samba. “The Neurosteroid Allopregnanolone and GABA-A Receptor Modulation in Epilepsy and Mood Disorders.” Frontiers in Neuroscience, vol. 12, 2018, 933. Schiller, Crystal E., et al. “The Neuroendocrinology of Perimenopausal Depression.” Trends in Neurosciences, vol. 44, no. 2, 2021, pp. 119–135. Schumacher, Michael, et al. “Neuroprotective Effects of Progesterone and Its Metabolites.” Frontiers in Neuroendocrinology, vol. 33, 2012, pp. 415–439. Selye, Hans. “The General Adaptation Syndrome and the Diseases of Adaptation.” Journal of Clinical Endocrinology, vol. 6, no. 2, 1946, pp. 117–230. Sheng, Jun, and György Buzsáki. “Neuronal Firing and Theta Oscillations in the Amygdala During Fear Conditioning.” Neuron, vol. 53, 2007, pp. 653–667. Smith, Sheryl S. “Progesterone Withdrawal Increases Neuronal Excitability in the Hippocampus: A GABA_A Mechanism.” Journal of Neuroscience, vol. 28, 2008, pp. 10171–10179. Snyder, Jonathan S., et al. “Adult Hippocampal Neurogenesis and Stress Regulation.” Nature Reviews Neuroscience, vol. 12, 2011, pp. 1–9. Stanczyk, Frank Z., and Jerilynn C. Prior. “Progesterone and Progestins: A Review of Pharmacology, PK, and Clinical Use.” Steroids, vol. 82, 2014, pp. 1–8. Tu, Ming-Je, et al. “Oral, Vaginal, and Transdermal Progesterone: PK, Metabolism, and Tissue Distribution.” Drug Metabolism Reviews, vol. 52, no. 2, 2020, pp. 1–28. Wang, Jun, et al. “Stress, Amygdala Plasticity, and the Neuroendocrine Interface.” Nature Neuroscience, vol. 10, 2007, pp. 1093–1100. Weinstock, Marta. “The Hippocampus and Chronic Stress.” Neurochemical Research, vol. 42, 2017, pp. 1–12. World Health Organization. Progesterone and Reproductive Function: Clinical Perspectives. WHO, 2019.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Cork's 96fm Opinion Line
Assisted Human Reproduction (AHR) has been established by the Minister for Health.

Cork's 96fm Opinion Line

Play Episode Listen Later Oct 15, 2025 11:53


Seamus Kearney of Martone Irish Gay Dads joins PJ to discuss the new Assisted Human Reproduction (AHR) Regulatory Authority has been established by the Minister for Health. Hosted on Acast. See acast.com/privacy for more information.

RTÉ - Morning Ireland
Ireland's first Assisted Human Reproduction Regulatory Authority established yesterday

RTÉ - Morning Ireland

Play Episode Listen Later Oct 14, 2025 5:15


Deirdre Madden, Professor of Law at UCC, and first Chair of the Assisted Human Reproduction Regulatory Authority, discusses how AHRRA will operate in the coming months.

Highlights from Newstalk Breakfast
A new 'Assisted Human Reproduction Regulatory Authority'

Highlights from Newstalk Breakfast

Play Episode Listen Later Oct 13, 2025 7:13


Minister for Health Jennifer Carroll MacNeill has today announced the Assisted Human Reproduction Regulatory Authority. It aims to protect the health and legal rights of children born through assisted reproduction or surrogacy, as well as the rights of intending parents and donors involved. We got the details from Dr Brian Tobin, Associate professor at University of Galway and member of the board.

Highlights from The Hard Shoulder
What is in the Assisted Human Reproduction Bill?

Highlights from The Hard Shoulder

Play Episode Listen Later Oct 13, 2025 10:06


Minister for Health Jennifer Carroll MacNeill has today announced the Assisted Human Reproduction Bill, which includes a legal framework for both domestic and international surrogacy. It aims to protect the health and wellbeing of the child, surrogate, and the intended parents of the children born through surrogacy.Joining guest host Jonathan Healy to discuss is Lawyer Annette Hickey.

Newstalk Breakfast Highlights
A new 'Assisted Human Reproduction Regulatory Authority'

Newstalk Breakfast Highlights

Play Episode Listen Later Oct 13, 2025 7:13


Minister for Health Jennifer Carroll MacNeill has today announced the Assisted Human Reproduction Regulatory Authority. It aims to protect the health and legal rights of children born through assisted reproduction or surrogacy, as well as the rights of intending parents and donors involved. We got the details from Dr Brian Tobin, Associate professor at University of Galway and member of the board.

Fertility and Sterility On Air
Fertility and Sterility On Air: Live from the ESHRE 41st Annual Meeting (Part 2)

Fertility and Sterility On Air

Play Episode Listen Later Sep 21, 2025 76:25 Transcription Available


Fertility & Sterility on Air is at the European Society of Human Reproduction and Embryology 41st Annual Meeting in Paris, France (Part 2)! In this episode, our hosts Kate Devine, Eve Feinberg, and Micah Hill cover: Discussing the state of assisted reproductive technology in Brazil with Giuliano Bedoschi (01:01) Whole transcriptome and genome sequencing of standard embryo biopsies can potentially reduce failed euploid transfers with Kaylene Ready and Jeremy Grushcow (09:03)  The use of AI in ovarian stimulation with Eduardo Hariton (19:45)  Modeling embryonic adhesion at cellular resolution within a microfluidic endometrium-on-a-chip platform with Sofia Zaragozano (32:33)  Assessing the ploidy status of atypically fertilised embryos – recovery of embryos for potential clinical use with Sharyn Stock-Myer (40:41)  Role of micronutrients and probiotics supplementation on reproductive outcomes in an oocyte donation program with Sara Maggi and Silvia Bonta (42:47)  Male infertility, life expectancy, and long-term health risks: exploring what can sperm reveal about health with Omar Ammar (58:00) Mitochondrial DNA ‘reversal' is common in children born following meiotic spindle transfer, potentially reducing the efficacy of mitochondrial replacement therapies with Munuse Savash (01:05:57) View Fertility and Sterility at https://www.fertstert.org/  

Fertility and Sterility On Air
Fertility and Sterility On Air: Live from the ESHRE 41st Annual Meeting (Part 1)

Fertility and Sterility On Air

Play Episode Listen Later Sep 14, 2025 57:21 Transcription Available


Fertility & Sterility on Air is at the European Society of Human Reproduction and Embryology 41st Annual Meeting in Paris, France (Part 1)! In this episode, our hosts Kate Devine, Eve Feinberg, and Micah Hill cover:  outcomes from programmed ovulatory frozen embryo transfer cycles vs. modified natural frozen embryo transfer cycles with Philippos Edimiris (0:56), non-invasive preimplantation genetic testing using metabolomics with Sofia Nunes (9:23), optimizing timing of modified natural cycle frozen embryo transfer cycles with Amelie Johansen and Kristine Løssl (17:46), mechanisms and consequences of ovarian aging with Francesca Duncan (27:18), comparing pregnancy loss rates in natural cycle vs. artificial cycle endometrial preparation prior to euploid embryo transfer with Caroline Roelens (38:24), and endometrial health and reproductive outcomes with Shari Mackens(49:44). View Fertility and Sterility at https://www.fertstert.org/  

Sausage of Science
SoS 247: Intergenerational Signals w/ Dr. Haley Ragsdale: A DOHaD Lens on Human Reproduction

Sausage of Science

Play Episode Listen Later Sep 2, 2025 35:52


Chris and Courtney sit down with Dr. Haley Ragsdale to discuss intergenerational signals of matrilineal experience. Haley completed her dissertation in Anthropology at Northwestern University in 2023 under the guidance of Dr. Chris Kuzawa. She is now a postdoctoral researcher in the Anthropology Department at the University of Illinois Chicago, collaborating with Dr. Katie Starkweather on fascinating projects related to maternal and child health among the Shodagor of Bangladesh. Haley's work is deeply rooted in evolutionary theory and the developmental origins of health and disease (DOHaD) framework, with a focus on human reproductive biology. She explores how energetic experiences shape lifetime metabolic strategies and how reproductive investments are influenced by varying environmental contexts. Currently, she's diving into the mechanisms behind intergenerational signals of matrilineal experience and predictive adaptive responses in humans. ------------------------------ Find the paper discussed in this episode: Ragsdale, H. B., Lee, N. R., & Kuzawa, C. W. (2024). Evidence that highly canalized fetal traits are sensitive to intergenerational effects of maternal developmental nutrition. American Journal of Biological Anthropology, 183(4), e24883. https://doi.org/10.1002/ajpa.24883 ------------------------------ Contact Haley: E-mail: hragsd2@uic.edu website: https://haleyragsdale.squarespace.com/; Google Scholar ------------------------------ Contact the Sausage of Science Podcast and Human Biology Association: Facebook: facebook.com/groups/humanbiologyassociation/, Website: humbio.org, Twitter: @HumBioAssoc Chris Lynn, Host Website: cdlynn.people.ua.edu/, E-mail: cdlynn@ua.edu, Twitter:@Chris_Ly Courtney Manthey, Guest-Co-Host, Website: holylaetoli.com/ E-mail: cpierce4@uccs.edu, Twitter: @HolyLaetoli Cristina Gildee, SoS Co-Producer, HBA Junior Fellow Website: cristinagildee.org, E-mail: cgildee@uw.edu,

Fertilidad sin censura
E157 - El futuro de la reproducción asistida

Fertilidad sin censura

Play Episode Listen Later Aug 16, 2025 8:46


¿Sabías que nuestro equipo de especialistas en fertilidad asistió al evento ESHRE 2025 (European Society of Human Reproduction and Embryology)? En este episodio, el Dr. Alfonso Suástegui

The Synchrony Podcast
Ep. 69 Fertility

The Synchrony Podcast

Play Episode Listen Later Jul 28, 2025 71:55


Trigger warning: this is a direct conversation about human anatomy, infertility, and gender-specific challenges to conceiving biological children. Discussions around fertility and age drive so much of who we select as dating partners, but are we basing those assumptions on facts, or myths? We'll dive in and see if we can help clarify how age should and shouldn't play into your assessment of who you should choose to marry and raise children with. See the bottom of the show notes for citations. Singles at SEA 2026: We'll be setting sail February 6-9, 2026 out of Miami, Florida on Wonder of the Seas and visiting The Bahamas! Prices subject to change, but you only need $200 to book a cabin/$100 per person if you book with a friend. Call Chelsea Fennell at 864-901-8233 Email: spinell@dreamvacations.com Get the From Singles, to Shepherds Info Guide Here! https://the-synchrony-project.mykajabi.com/from-singles-to-shepherds Contact: If you want to join the conversation about this topic and give your thoughts, reach out on Instagram, Facebook, YouTube, or at questions@synchronyproject.com. Learn more about our matchmaking services and dating resources at https://synchronyproject.com. Intro/Outro music by: Balloon Planet, "Write Your Own Story," https://artlist.io/royalty-free-music/song/write-your-own-story/135437 Citations for this episode: Prevalence and factors associated with infertility in reproductive-aged women in China Reproductive Health (2021) https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-021-01298-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253726/ Semen quality and aging: systematic review and meta-analysis Asian Journal of Andrology (2018) https://www.sciencedirect.com/science/article/pii/S2090598X18300068 Age-related increase in sperm DNA fragmentation: A prospective study Frontiers in Aging (2025) https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2025.1603916/full Effects of age on semen parameters and ART outcomes: A systematic review Frontiers in Endocrinology (2023) https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1194455/full Semen parameters decline with age in healthy men Human Reproduction (2006) https://academic.oup.com/humrep/article/21/11/2868/2939168 Temporal trends in sperm count: A systematic review and meta-regression analysis Human Reproduction Update (2017) https://academic.oup.com/humupd/article/23/6/646/4035689 Delayed childbearing: More women are having their first child later in life OECD Society at a Glance (2024) https://webfs.oecd.org/els-com/Family_Database/SF_2_3_Age_mothers_childbirth.pdf OECD Society at a Glance 2024 – Fertility Chapter OECD (2024) https://www.oecd.org/en/publications/society-at-a-glance-2024_918d8db3-en/full-report/fertility_748a5055.html Spain has some of the oldest first-time mothers in the world Business Insider (2024) https://www.businessinsider.com/spain-some-oldest-moms-world-babies-born-women-over-40-2024-12 CDC National Health Statistics Reports: Male Fertility in the US (2015–2019) CDC / NCHS https://www.cdc.gov/nchs/data/nhsr/nhsr202.pdf

Choses à Savoir SCIENCES
Pourquoi il y a de plus en plus de jumeaux et jumelles qui naissent en France ?

Choses à Savoir SCIENCES

Play Episode Listen Later Jun 2, 2025 2:16


C'est un phénomène discret mais spectaculaire : depuis les années 1980, la France — comme la plupart des pays développés — connaît une hausse marquée du nombre de naissances de jumeaux et jumelles. On parle même d'un « baby boom des jumeaux ». Selon une étude publiée dans la revue Human Reproduction en 2021, le taux de naissances gémellaires a augmenté de plus de 30 % en quatre décennies dans les pays à revenu élevé. Mais d'où vient cette explosion ? Et surtout, quelles en sont les implications médicales ?PMA, FIV : des jumeaux de laboratoire ?La première cause identifiée, c'est l'essor des techniques de procréation médicalement assistée (PMA), notamment la fécondation in vitro (FIV), depuis les années 1980. Lors d'une FIV, il est courant que plusieurs embryons soient implantés dans l'utérus pour augmenter les chances de réussite. Résultat : les grossesses multiples sont plus fréquentes. Et même lorsque la stimulation ovarienne est utilisée sans FIV, elle peut favoriser la libération de plusieurs ovules, augmentant le risque de conception gémellaire.Des mères plus âgées… et plus grandesMais la technologie ne fait pas tout. Un autre facteur important est l'âge de la mère. À partir de 35 ans, les femmes ont plus souvent des cycles où plusieurs ovocytes sont libérés en même temps. Or, l'âge moyen de la première maternité n'a cessé d'augmenter en France, passant de 26 à près de 31 ans entre 1975 et aujourd'hui.La taille et le poids de la mère jouent également un rôle. Les femmes plus grandes ou ayant un indice de masse corporelle (IMC) plus élevé ont un risque légèrement supérieur d'avoir des jumeaux. Il ne s'agit pas ici de juger ces facteurs, mais de constater une tendance biologique.Et la génétique ?Côté hérédité, les jumeaux dizygotes (issus de deux ovules fécondés séparément) sont plus fréquents dans certaines familles. Si une femme a déjà eu des jumeaux ou si elle a des antécédents familiaux, ses chances en sont augmentées. À l'inverse, les jumeaux monozygotes (issus d'un même ovule divisé en deux) semblent répartis plus aléatoirement dans la population.Une grossesse à risquesMais cette hausse n'est pas sans conséquences : les grossesses gémellaires comportent plus de risques, à la fois pour la mère (hypertension, diabète gestationnel) et pour les bébés (prématurité, faible poids à la naissance). Les médecins recommandent donc un suivi renforcé pour ces grossesses multiples.En somme, le « baby boom des jumeaux » est le fruit d'une rencontre entre progrès médical, évolutions sociales et facteurs biologiques. Une aventure à deux… qui demande parfois deux fois plus de précautions. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Do you really know?
Are twins really telepathic ?

Do you really know?

Play Episode Listen Later Mar 17, 2025 5:01


According to a study published in Human Reproduction in 2021, there are around 1.6 million twins born each year, with an average of one in every 42 newborn children being a twin. The research also revealed that the global twinning rate had increased by a third since the 1980s. It's fair to say that twins have long fascinated scientists, and society as a whole. Some people portray twins as kind of identical clones with supernatural powers. They suggest that twins are capable of communicating telepathically and experiencing each other's emotions, even from great distances.   Do twins really share a special bond ? Have twins similar behaviors ? In under 3 minutes, we answer your questions! To listen to the last episodes, you can click here: Why do people say that black cats bring bad luck? What are the dirtiest objects in your home? Why do we get travel sick? A Bababam Originals podcast written and realised by Joseph Chance. Learn more about your ad choices. Visit megaphone.fm/adchoices

Wissensnachrichten - Deutschlandfunk Nova
Meereis, Spermien, Milliardäre

Wissensnachrichten - Deutschlandfunk Nova

Play Episode Listen Later Mar 6, 2025 5:13


Die Themen in den Wissensnachrichten: +++ Meereis an Nord- und Südpol schrumpft auf historisches Tief +++ Männer mit besserer Sperma-Qualität leben länger +++ Milliardäre in Deutschland sind meistens Männer +++**********Weiterführende Quellen zu dieser Folge:Copernicus: Global sea ice cover at a record low and third-warmest February globally, Copernicus, 5.3.2025Semen quality and lifespan: a study of 78 284 men followed for up to 50 years, Human Reproduction, 5.3.2025Systematic bone tool production at 1.5 million years ago, Nature, 5.3.2025Männer, Milliarden, Macht: Wie die fehlende Besteuerung von Vermögen Geschlechterungleichheit zementiert, Oxfam Deutschland, 6.3.2025Urban highways are barriers to social ties, PNAS, 4.3.2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok auf&ab , TikTok wie_geht und Instagram .

Conscious Fertility
89: Decoding Hormonal Balance: The Power of Progesterone with Dr. Jerilynn Prior

Conscious Fertility

Play Episode Listen Later Dec 30, 2024 58:16


In this episode of Conscious Fertility, host Dr. Lorne Brown engages in an enlightening conversation with Dr. Jerilynn Prior, a trailblazing endocrinologist and professor at the University of British Columbia. Dr. Prior shares her 40+ years of research on the importance of progesterone in women's reproductive health, the reality of hormonal fluctuations during perimenopause, and how understanding ovulatory disturbances can promote lifelong well-being. This episode is a must-listen for women seeking to optimize their fertility, manage perimenopausal symptoms, and gain deeper insights into their menstrual health.Key takeaways:The importance of balancing estrogen with progesterone for reproductive and overall health.Ovulatory disturbances are common and adaptive but need attention when persistent.Perimenopausal symptoms are often linked to fluctuating estrogen levels and insufficient progesterone.Regular ovulation predicts better bone, heart, and lifelong health.Progesterone therapy effectively reduces menopausal symptoms like night sweats and sleep disturbances.Dr. Jerilynn Prior Bio: Jerilynn C. Prior is a 40+ year University of British Columbia Endocrinology Professor. An award-winning Clinician-Scientist (Michael Smith Foundation for Health Research, 2019), her innovative concepts are changing women's reproduction. Progesterone needs to be in balance with estradiol for well-being and fertility during the premenopausal years and for lifelong good health. She founded the UBC Centre for Menstrual Cycle and Ovulation Research (CeMCOR, 2002). Prior is an internationally recognized thought leader on menstrual cycles, ovulation, perimenopause, menopause, osteoporosis prevention and night sweats treatment with an H-Index of 75. Her controlled trials show progesterone decreases menopausal VMS and increases bone formation. Prior grew up in Alaskan fishing villages, got an honors MD from Boston University (1969) and became Canadian (1983) due to her belief in universal health care. Where To Find Dr. Jerilynn Prior: CEMCOR - Center for Menstrual Cycle and Ovulation Research - https://cemcor.ubc.ca/Books: Estrogen's Storm Season - https://www.amazon.ca/dp/B078JSRFKRRESEARCHS: Menstrual cycle, follicular and luteal phase variabilitiesHere's a paper we just published in Human Reproduction—showing that it is nonsense to believe the luteal phase is fixed at 14 days. Henry, Sarah https://doi.org/10.1093/humrep/deae215 Menstrual cramps and ovulation Because menstrual cramps are said to only occur in ovulatory cycles, we analyzed cramps in both groups—women with anovulation had more intense cramps that lasted longer! https://doi:10.2147/JPR.S457484. Very important when discussing perimenopause We showed significantly decreased night sweats and improved sleep, no change in periods and a significant decrease in perimenopausal interference with daily life.Here's the open access link

Mind Love • Modern Mindfulness to Think, Feel, and Live Well
The Heart-Uterus Connection: The Emotional and Physical Links in Fertility with Michelle Oravitz • 371

Mind Love • Modern Mindfulness to Think, Feel, and Live Well

Play Episode Listen Later Oct 22, 2024 59:05


We will learn: How the ancient wisdom of Traditional Chinese Medicine views the connection between the heart and uterus, and why this matters for your fertility journey. The power of conscious creation and how your thoughts and visualizations can influence your reproductive health. Practical techniques to reduce stress and promote the free flow of energy in your body, potentially enhancing your fertility. Have you ever felt like your body has a mind of its own, especially when it comes to fertility? Like no matter how much you plan or hope, your reproductive journey seems to have its own mysterious timeline?Studies have shown that chronic stress can affect everything from our immune system to our hormonal balance. In fact, research published in the journal Human Reproduction found that women with high levels of stress enzymes in their saliva were 29% less likely to get pregnant compared to those with lower levels.What if the key to unlocking our fertility potential lies not just in medical interventions, but in understanding the intricate dance between our mind, body, and spirit?In this episode we're exploring different perspectives, gaining new insights, and discovering tools you can use on your own unique journey.Our guest is Michelle Oravitz. She is an acupuncturist specializing in fertility health. She hosts "The Wholesome Fertility Podcast," a top-rated podcast where she interviews leading experts and best-selling authors and provides her own fertility wellness tips. During her free time, Michelle enjoys spending time with her family, reading, doing yoga, meditating, and painting.Links from the episode: Show Notes: https://mindlove.com/371 Become a Mind Love Member for high-value Masterclasses, Growth Workbooks, Monthly Meditations, and Uninterrupted Listening FREE 5-Days to Purpose Email Course Sign up for The Morning Mind Love for short daily notes to wake up inspired Support Mind Love Sponsors Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mind Love • Modern Mindfulness to Think, Feel, and Live Well
The Heart-Uterus Connection: The Emotional and Physical Links in Fertility with Michelle Oravitz • 371

Mind Love • Modern Mindfulness to Think, Feel, and Live Well

Play Episode Listen Later Oct 22, 2024 64:05


We will learn: How the ancient wisdom of Traditional Chinese Medicine views the connection between the heart and uterus, and why this matters for your fertility journey. The power of conscious creation and how your thoughts and visualizations can influence your reproductive health. Practical techniques to reduce stress and promote the free flow of energy in your body, potentially enhancing your fertility. Have you ever felt like your body has a mind of its own, especially when it comes to fertility? Like no matter how much you plan or hope, your reproductive journey seems to have its own mysterious timeline? Studies have shown that chronic stress can affect everything from our immune system to our hormonal balance. In fact, research published in the journal Human Reproduction found that women with high levels of stress enzymes in their saliva were 29% less likely to get pregnant compared to those with lower levels. What if the key to unlocking our fertility potential lies not just in medical interventions, but in understanding the intricate dance between our mind, body, and spirit? In this episode we're exploring different perspectives, gaining new insights, and discovering tools you can use on your own unique journey. Our guest is Michelle Oravitz. She is an acupuncturist specializing in fertility health. She hosts "The Wholesome Fertility Podcast," a top-rated podcast where she interviews leading experts and best-selling authors and provides her own fertility wellness tips. During her free time, Michelle enjoys spending time with her family, reading, doing yoga, meditating, and painting. Links from the episode: Show Notes: https://mindlove.com/371 Become a Mind Love Member for high-value Masterclasses, Growth Workbooks, Monthly Meditations, and Uninterrupted Listening FREE 5-Days to Purpose Email Course Sign up for The Morning Mind Love for short daily notes to wake up inspired Support Mind Love Sponsors Learn more about your ad choices. Visit megaphone.fm/adchoices

Intelligent Medicine
Leyla Weighs In: Sperm Quality and Diet–The Role of Ultra-Processed Foods

Intelligent Medicine

Play Episode Listen Later Oct 4, 2024 23:20


Nutritionist Leyla Muedin discusses the impact of ultra-processed food (UPF) consumption on sperm quality, referencing a study from the journal Human Reproduction. Findings indicate higher UPF intake is linked to lower sperm count, concentration, and motility in Spanish men. Leyla also explores a study on the effects of a lifelong vegetarian diet on male fertility in Loma Linda's Blue Zone population. She emphasizes that ultra processed foods and higher body mass index (BMI) correlate with deteriorating sperm quality, suggesting whole foods as a healthier dietary choice to improve fertility.

RNZ: Nine To Noon
Predictions for the future of human reproduction

RNZ: Nine To Noon

Play Episode Listen Later Oct 3, 2024 27:07


We've all heard of IVF - invitro fertilisation - but what about IVG ? In vitro gametogenesis involves making human eggs and sperm in the laboratory from any cell in a person's body. This means IVG could see same-sex couples have genetically related children.

FertiliPod: Reproductive Medicine and Fertility podcast for professionals

Recording of live IVIRMA Journal Club. Dr. Nola Herlihy presents a randomized controlled trial recently published in Human Reproduction on the use of platelet-rich plasma (PRP) in patients with poor ovarian response (POR). Drs. Manuel Muñoz and Emre Seli offer expert commentary on the use of PRP from the clinical and research perspectives, followed by Q&A from the audience. Podcast website: https://www.ivi-rmainnovation.com/fertilipod/

Learning With Lowell
Dr. Olivia Lesslar and Dr. Alexander Layendecker: Space Sex, Longevity, & Brain Injuries with – 253

Learning With Lowell

Play Episode Listen Later Aug 13, 2024 114:09


In this episode of the Learning with Lowell podcast, host Lowell Thompson welcomes Olivia Lesslar and Alexander Layendecker, two experts in the fields of space life sciences and medicine. The discussion delves into the challenges and innovations surrounding human health and reproduction in space. Topics covered include the impacts of microgravity and radiation on human physiology, the intersection of longevity research with space sciences, and the potential for space research to address earthly health issues. The conversation also explores cutting-edge advancements in quantum medicine, neuroplasticity, and the role of light and electromagnetism in healing. The episode provides insights into the upcoming symposium on human reproduction in space and emphasizes the importance of holistic approaches to health, both on Earth and in space. PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com Dr. Olivia Lesslar and Dr.Alexander Layendecker linkshttps://www.linkedin.com/in/drolivialesslar/https://www.drolivialesslar.com/https://www.asri.space/ Timestamps00:00 - Introduction and Importance of Subscribing01:00 - Guest Introductions: Olivia and Alex's Backgrounds04:00 - Discussion on Space Life Sciences and Research07:30 - Challenges and Risks of Human Reproduction in Space12:00 - Health Impacts of Microgravity and Radiation16:00 - Overlapping Research in Longevity and Space Sciences19:30 - Environmental Factors and Human Health24:00 - Importance of Sleep and Brain Health28:00 - The Effects of Breathing and Stress on Health33:00 - Rehabilitation and Healing Strategies for Brain Injuries38:00 - Advancements in Quantum Medicine and Mitochondrial Health43:30 - The Intersection of Light, Electromagnetism, and Healing49:00 - Legacy Sciences and Azri's Mission53:00 - Future of Space Travel and Human Adaptation57:00 - The Psychological and Social Impact of Space Exploration1:02:00 - Addressing Challenges on Earth Through Space Research1:07:30 - Symposium on Human Reproduction in Space1:11:00 - Impact of Space Research on Earthly Issues1:15:00 - Audience Engagement and Future Directions1:18:00 - Questions about Human Behavior and Health in Space1:22:00 - Intersection of Historical Perspectives and Modern Issues1:27:00 - Personal Insights and Anecdotes from Olivia and Alex1:32:00 - Final Thoughts on Space Exploration and Its Benefits1:36:00 - Historical and Personal Reflections on War and Conflict1:40:00 - Reflections on Public Perceptions and Social Media's Impact1:44:00 - Ethical Considerations and the Role of Science in Society1:48:00 - Future Projects and Research Initiatives1:52:00 - Engaging the Public and Building Awareness longevity #reproduction #space

Trail Society
Episode 78: New Research Updates on the Impact of the Menstrual Cycle on Performance and Return to Sport After Periods of Low Energy Availability

Trail Society

Play Episode Listen Later Jul 18, 2024 78:34


In this episode, Keely, Corrine, and Hillary discuss various life events and races before delving into recent research. First, they explore the current state of menstrual cycle research, highlighting areas of improvement and those that still have a way to go. They then discuss the impact of menstrual-related symptoms on mental health and spatial performance. As coaches, they share their approaches to addressing the menstrual cycle for athletes who menstruate, including tracking the cycle and adapting training to meet individual athletes' specific needs. Finally, they touch on Low Energy Availability (LEA) and RED-S, highlighting recent research showing that LEA can manifest in as little as 3 days. They also discuss coaching strategies for helping athletes recover from short-term and long-term LEA periods. Disclaimer: This podcast does not provide medical advice, but rather shares recent information in these two areas. Listeners are advised to always discuss their unique needs with a licensed professional.   Sponsors: This episode is brought to you by Freetrail @runfreetrail www.freetrail.com - subscribe and JOIN US IN SLACK & Our Title Sponsor is The Feed!!! Follow the link to get $20 to spend every quarter ($80 every year!): https://thefeed.com/trailsociety + a cool Trail Society water bottle!   Articles Referenced: Menstrual Cycle and Performance: Smith ES, Weakley J, McKay AKA, McCormick R, Tee N, Kuikman MA, Harris R, Minahan C, Buxton S, Skinner J, Ackerman KE, Elliott-Sale KJ, Stellingwerff T, Burke LM. Minimal influence of the menstrual cycle or hormonal contraceptives on performance in female rugby league athletes. Eur J Sport Sci. 2024 Jun 15. doi:10.1002/ejsc.12151. PMID: 38877892.   Menstrual Cycle and Birth Control Nolan, David, et al. “The Effect of Hormonal Contraceptive Use on Skeletal Muscle Hypertrophy, Power and Strength Adaptations to Resistance Exercise Training: A Systematic Review and Multilevel Meta-Analysis.” Sports Medicine (Auckland, N.Z.), 27 Sept. 2023, pubmed.ncbi.nlm.nih.gov/37755666/, https://doi.org/10.1007/s40279-023-01911-3. Accessed 15 Oct. 2023. Ihalainen, Johanna K., et al. “Self-Reported Performance and Hormonal-Cycle-Related Symptoms in Competitive Female Athletes.” Women in Sport and Physical Activity Journal, vol. 32, no. 1, 2 July 2024, journals.humankinetics.com/view/journals/wspaj/32/1/article-wspaj.2023-0102.xml, https://doi.org/10.1123/wspaj.2023-0102.     Menstrual Cycle, Behavioral, and Cognitive Parameters   Ronca,F., et al. Attentional, anticipatory and spatial cognition fluctuate throughout the menstrual cycle: Potential implications for female sport. In- Press. Neuropsychologia 17 May 2024. https://www.sciencedirect.com/science/article/pii/S0028393224001246?via%3Dihub     Kullik, Lisa, et al. “The Prevalence of Menstrual Cycle Symptoms and Their Association with Mental Health and Sleep in German Exercising Women and Athletes.” Journal of Science and Medicine in Sport, 1 Feb. 2024, https://doi.org/10.1016/j.jsams.2024.02.008.   LEA, return to sport, impacts of short-term LEA, and menstrual dysfunction   De Souza, Mary Jane, et al. “Randomised Controlled Trial of the Effects of Increased Energy Intake on Menstrual Recovery in Exercising Women with Menstrual Disturbances: The “REFUEL” Study.” Human Reproduction, vol. 36, no. 8, 24 June 2021, pp. 2285–2297, https://doi.org/10.1093/humrep/deab149. Accessed 25 Nov. 2021. Hutson, Mark J, et al. “High‐Impact Jumping Mitigates the Short‐Term Effects of Low Energy Availability on Bone Resorption but Not Formation in Regularly Menstruating Females: A Randomized Control Trial.” Scandinavian Journal of Medicine & Science in Sports, vol. 33, no. 9, 26 June 2023, pp. 1690–1702, https://doi.org/10.1111/sms.14437. Accessed 7 Dec. 2023. Hutson, Mark J., et al. “Effects of Low Energy Availability on Bone Health in Endurance Athletes and High-Impact Exercise as a Potential Countermeasure: A Narrative Review.” Sports Medicine, vol. 51, no. 3, 21 Dec. 2020, pp. 391–403, https://doi.org/10.1007/s40279-020-01396-4.

Fertility and Sterility On Air
Fertility and Sterility On Air - Seminal Article: Ernest Ng, and Zhi Chen

Fertility and Sterility On Air

Play Episode Listen Later Jun 30, 2024 17:55


Fertility & Sterility on Air brings you a deep dive into the June issue Seminal Contribution: a randomized controlled trial studying the use of progestins for ovulation supression in predicted high responders. With Micah Hill, Ernest Ng, and Zhi Chen. Read the article: https://www.fertstert.org/article/S0015-0282(24)00030-X/abstract View Fertility and Sterility at https://www.fertstert.org/  

FertiliPod: Reproductive Medicine and Fertility podcast for professionals
Journal Club: Machine Learning and Morphokinetics for Embryo Ploidy

FertiliPod: Reproductive Medicine and Fertility podcast for professionals

Play Episode Listen Later Jun 28, 2024 44:10


Recording of live IVIRMA Journal Club. Dr. Belén Aparicio presents an article comparing different machine learning algorithms involving embryo grading and morphokinetics to predict embryo euploidy. Drs. Laura Rienzi and Denny Sakkas comment on the role of artificial intelligence (AI) in IVF and in the embryology lab, followed by Q&A from the audience. Podcast website: https://www.ivi-rmainnovation.com/fertilipod/

RTÉ - Drivetime
Families welcome new laws on assisted human reproduction

RTÉ - Drivetime

Play Episode Listen Later Jun 26, 2024 10:24


The Assisted Human Reproduction Bill, which includes a legal framework for both domestic and international surrogacy, has passed all stages in the Oireachtas. To discuss this further now is Fine Gael Senator Mary Seery Kearney and Cathy Wheatly who is the spokesperson for Irish Families Through Surrogacy.

NGO Soul + Strategy
073. From a hub and spoke to a horizontal network model: Anu Kumar @ Ipas

NGO Soul + Strategy

Play Episode Play 27 sec Highlight Listen Later Mar 31, 2024 55:37


SummaryWhat are the main benefits of a network structure, where power, authority, and leadership are dispersed and shared across regions, from an effectiveness perspective? What are the most important enabling habits, practices and behaviors that go with that, as a change leader?And what are the most valuable network-related frameworks, concepts, resources, and tools at work in moving towards this structure?In this NGO Soul+Strategy podcast episode, I interview Anu Kumar, President and CEO at Ipas, on the why, the what, and the how of changing an organization from a hub and spoke to a horizontal NGO model. Anu's Bio:President and CEO at IpasFormer Chief Strategy and Development Officer as well as Executive Vice President at IpasSenior Program Officer, Program on Global Security and Sustainability, Population and Reproductive Rights, MacArthur FoundationProgram Officer, MacArthur FoundationSocial Scientist in Human Reproduction, WHO We discuss: Ipas is the leading technical org that advocates for access to contraception and abortion services, globallyTraditionally, Ipas has had a hub-and-spoke organizational model, like many traditional NGOsA strategy change – for Ipas to contribute to a sustainable global contraception and abortion access ecosystem – demanded that countries would take over much of the lead in Ipas. So form followed functionIpas started its change towards a network model by defining what decentralization meant for itselfIt then defined shared leadership as its management model, and articulated change behaviors, practices, and management set-up as required next stepsSubsequently, it changed its structure to that of a network in which the US no longer was the primary member, and a Network Leadership Group, a Staff Community Council, and a NetCare group were formed -- the latter nurtures the networkIpas explicitly chose not to become a (con)federated organization and to remain a corporate hierarchical structureAs a next step, it adopted horizontal decision-making for some of its decision-making on budget aspects and recruitmentAdopting a horizontal management approach does *not* mean there is no hierarchy anymore: the CEO, CFO, and a few other executive leaders still have some positional power, but their  realm of decision-making is now reducedDecentralized decision-making means faster decision-making; more cross-country collaboration is also happening that's not involving the US.Role clarity is still an issue to be improved upon. On the other hand, global coherence was facilitated through a codified collaboration agreementIpas' board, still based in the US, retains fiduciary responsibilities, so compliance continues to be important Resources:Anu's LinkedIn ProfileIpas WebsiteLinkedIn article on Ipas change approach by Anu KumarBridgespan consulting group article on Re-imagining Multi-Country NGO Operating ModelsSamantha Slade's book was informative for Ipas's change journey: Going Horizontal YouTube 

Building your family
Getting pregnant over 40 is what these doctors specialize in

Building your family

Play Episode Listen Later Mar 31, 2024 51:30


In this podcast, we frequently delve into the realm of third-party reproduction. However, today we're taking a fresh perspective on the pregnancy journey. Donor conception isn't the perfect fit for everyone, and for some, it simply isn't an option. So, let's explore an alternative approach. Meet Dr. Gleicher and Dr. Barad, partners at the Center for Human Reproduction in New York. Their focus over the years has gravitated towards women categorized as having an "advanced maternal age". In this episode, they generously share insights into the strategies that have brought success to their patients. What's reassuring is their commitment to ensuring informed consent. They steer clear of empty promises and quick fixes. Instead, they lay out the reality, often modest success rates for women in their 40s, empowering patients to make informed decisions about their treatment paths. Despite embracing some unconventional methods, their research garners respect within the medical community. If you, or a loved one, want to attempt pregnancy at an advanced maternal age, you will find this episode very helpful.     If you are interested in any of the topics discussed in this episode... Subscribe to the YouTube channel here: https://www.youtube.com/@thecenterforfamilybuilding You can also find me and lots of great resources at https://familybuilding.net/ Join our community, We would love to have you. https://familybuilding.net/newsletter-sign-up/ Author: Building Your Family; The Complete Guide to Donor Conception https://read.macmillan.com/lp/building-your-family/ Follow me here: Instagram: https://www.instagram.com/thecenterforfamilybuilding/ Facebook: https://www.facebook.com/thecenterforfamilybuilding/ Twitter: https://twitter.com/FamilyBuild TikTok: https://www.tiktok.com/@familybuildingcenter Looking for My Lifebook? https://a.co/d/deSACrM  

Reasonable Faith Podcast
Questions on Human Reproduction, Heaven, and Islam

Reasonable Faith Podcast

Play Episode Listen Later Mar 19, 2024 22:38


Why would God create someone whom he knows will reject him? Will we be bored in heaven if everything is perfect? These and other questions are discussed by Dr. Craig.

Dr. Chapa’s Clinical Pearls.
AMH in PCOS DX: 2023 PCOS Update

Dr. Chapa’s Clinical Pearls.

Play Episode Listen Later Dec 15, 2023 46:01


According to ACOG's CO 773 from 2019, “Currently, serum antimüllerian hormone levels are not part of the accepted diagnostic criteria for polycystic ovary syndrome (PCOS)”. But medicine moves fast, and that statement is no longer valid, at least it isn't valid from the ASRM July 2023 Standpoint. Yep, once considered experimental, AMH has now entered the PCOS diagnostic algorithm. Nonetheless, some important limitations and facts must be understood for its use in this way. In this episode, we will highlight the recommendations from the 2023 international, evidence-based guideline for the assessment and management of polycystic ovary syndrome, focusing on the role of AMH. We will also discuss the condition in adolescents and why this diagnosis is DIFFERENT in this group, and the update to the number of follicles per ovary (FNPO) recommended for the diagnosis. This guideline has been co-published in Fertility and Sterility, Human Reproduction, European Journal of Endocrinology, and The Journal of Clinical Endocrinology and Metabolism.

The Whole Pineapple
Episode 46: The End of Sex with Hank Greely

The Whole Pineapple

Play Episode Listen Later Dec 1, 2023 61:44


Sorry, folks, it's official: it's the end of sex.* Henry “Hank” Greely, Professor by courtesy of Genetics at Stanford School of Medicine, Deane F. and Kate Edelman Johnson Professor of Law, and Director of the Center for Law and the Biosciences, is very interested in how new biomedical technologies impact assisted reproduction. He's authored two books: The End of Sex and the Future of Human Reproduction in 2016, and CRISPR People: The Science and Ethics of Editing Humans, which published in 2021, and is Chair of the Steering Committee of the Center for Biomedical Ethics, among other impressive mouthfuls. In this episode, Ruby, Anne, and Hank dive into the changes that are already happening in human reproduction — and the possible changes to come. In addition to the scientific challenges, what are the ethical and legal questions we'll need to tackle as the landscape changes? Many of us became aware of genetic questions with Dolly the cloned sheep and the controversy over stem cells and how they might be used to repair damaged bodies. But Hank took the question even further, asking, What happens when we can make eggs and sperm from skin cells? Does that signal the end of human reproduction as we know it? Hank can pinpoint the origin of his curiosity to October 19, 2010 in Muenster, Germany — a conference talk on how induced pluripotent stem cells (iPscs) could be used to make other cells, including, the speaker said off-handedly, sperm and eggs. Wait, what? Science fiction? Maybe not. If you're curious about the possible future of fertility (and sex), this is the episode for you. Be sure to check out the book as well. There's not only theory about what the future could hold but also a well-researched history of how we've gotten here  As always, please rate and review, and most of all, share the episode and show with anyone you think could benefit.  *Spoiler: New technologies might mean the end of sex for reproduction and the start of sex purely for pleasure. So the news isn't bad after all.  Learn more about Hank Greely on the Stanford Law School Directory: https://law.stanford.edu/directory/henry-t-greely/ Find more episodes from Ruby and Anne at https://thewholepineapple.com.   Resources mentioned: Purchase the book from the Harvard University Press: https://www.hup.harvard.edu/catalog.php?isbn=9780674984011 Episode 29: My Embryos are Mosaic? https://thewholepineapple.com/episode-29-my-embryos-are-mosaic-interpreting-your-pgt-results/  

The Ben Armstrong Show
Covid Vax is a War Against Human Reproduction Says Dr. Naomi Wolf

The Ben Armstrong Show

Play Episode Listen Later Aug 28, 2023 24:04


Depopulation is a well known belief and goal of the globalists. So why are people shocked when we tell them the vaccine is a bioweapon to depopulate the earth? Watch the video for more. DISCLAIMER: Views and opinions expressed on The Ben Armstrong Show are solely those of the host and do not necessarily represent those of ... The post Covid Vax is a War Against Human Reproduction Says Dr. Naomi Wolf appeared first on The New American.

Frankly Speaking About Family Medicine
Beyond the Prescription Pad: Over-the-Counter Oral Contraceptive Gains FDA Approval - Frankly Speaking Ep 342

Frankly Speaking About Family Medicine

Play Episode Listen Later Aug 21, 2023 11:20


Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-342 Overview: In July of 2023, the FDA made a monumental decision to approve Opill, marking the first time an oral contraceptive will be made available without a prescription. The inaugural over-the-counter oral contraceptive is a progesterone-only pill. Join us to discuss the underlying rationales driving this decision and the prospective implications it might have on medical practice as well as women's health. Episode resource links: Biggs, AM, Ralph, L, Morris, N, Ehrenreich, K, Perritt, J, Kapp, N, Blanchard, K, White, K,  Barar, Grossman, RD. A cross-sectional survey of U.S. abortion patients' interest in obtaining medication abortion over the counter, Contraception, Volume 109, 2022, Pages 25-31, ISSN 0010-7824, https://doi.org/10.1016/j.contraception.2022.01.010.   Chen, Q.J. Xiang, W.P. Zhang, D.K., Wang, R.P. Luo, Y.F. Kang, J.Z. Cheng, L.N. Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial, Human Reproduction, Volume 26, Issue 9, September 2011, Pages 2316–2321, https://doi.org/10.1093/humrep/der181   Raine, TR; Ricciotti, N; Sokoloff, A; Brown, B; Hummel, A; Harper, C. An Over-the-Counter Simulation Study of a Single-Tablet Emergency Contraceptive in Young Females. Obstetrics & Gynecology 119(4):p 772-779, April 2012. | DOI: 10.1097/AOG.0b013e31824c0aed   https://www.fda.gov/news-events/press-announcements/fda-approves-first-nonprescription-daily-oral-contraceptive   https://www.accessdata.fda.gov/drugsatfda_docs/nda/2023/017031Orig1s041SumR.pdf Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Richard Onorato

Pri-Med Podcasts
Beyond the Prescription Pad: Over-the-Counter Oral Contraceptive Gains FDA Approval - Frankly Speaking Ep 342

Pri-Med Podcasts

Play Episode Listen Later Aug 21, 2023 11:20


Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-342 Overview: In July of 2023, the FDA made a monumental decision to approve Opill, marking the first time an oral contraceptive will be made available without a prescription. The inaugural over-the-counter oral contraceptive is a progesterone-only pill. Join us to discuss the underlying rationales driving this decision and the prospective implications it might have on medical practice as well as women's health. Episode resource links: Biggs, AM, Ralph, L, Morris, N, Ehrenreich, K, Perritt, J, Kapp, N, Blanchard, K, White, K,  Barar, Grossman, RD. A cross-sectional survey of U.S. abortion patients' interest in obtaining medication abortion over the counter, Contraception, Volume 109, 2022, Pages 25-31, ISSN 0010-7824, https://doi.org/10.1016/j.contraception.2022.01.010.     Chen, Q.J. Xiang, W.P. Zhang, D.K., Wang, R.P. Luo, Y.F. Kang, J.Z. Cheng, L.N. Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial, Human Reproduction, Volume 26, Issue 9, September 2011, Pages 2316–2321, https://doi.org/10.1093/humrep/der181   Raine, TR; Ricciotti, N; Sokoloff, A; Brown, B; Hummel, A; Harper, C. An Over-the-Counter Simulation Study of a Single-Tablet Emergency Contraceptive in Young Females. Obstetrics & Gynecology 119(4):p 772-779, April 2012. | DOI: 10.1097/AOG.0b013e31824c0aed   https://www.fda.gov/news-events/press-announcements/fda-approves-first-nonprescription-daily-oral-contraceptive   https://www.accessdata.fda.gov/drugsatfda_docs/nda/2023/017031Orig1s041SumR.pdf Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Richard Onorato

The Life Challenges Podcast
Episode 98: The Future of Human Reproduction

The Life Challenges Podcast

Play Episode Play 45 sec Highlight Listen Later Aug 1, 2023 33:10


Join us as we take a look at where reproduction is headed and the important things to remember when thinking about the future.  Support the show

Consider This from NPR
New Research Could Change the Landscape of Human Reproduction

Consider This from NPR

Play Episode Listen Later Jul 18, 2023 12:02


One of the most cutting-edge and controversial fields of biomedical research right now is the quest to create eggs and sperm in the lab for anyone with their own DNA. And now, private companies have jumped into the race to revolutionize the way humans reproduce.In vitro gametogenesis, or IVG, would enable infertile women and men to have children with their own DNA instead of genes from the sperm and eggs of donors. It would also provide queer couples the opportunity to have children biologically related to both partners. NPR health correspondent Rob Stein reports on the excitement and concerns this new technology has fueled.In participating regions, you'll also hear a local news segment to help you make sense of what's going on in your community.Email us at considerthis@npr.org.

IJGC Podcast
Predictors of SLN Mapping Failure with Diego Raimondo and Giulia Rovero

IJGC Podcast

Play Episode Listen Later Jun 5, 2023 25:32


In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Drs. Diego Raimondo and Giulia Rovero. Dr. Raimondo works as medical director and assistant researcher at the Division of Gynecology and Pathophysiology of Human Reproduction, Bologna, Italy, directed by Prof. Renato Seracchioli. He received his PhD on new technologies for endometriosis surgical removal from the University of Bologna in 2021. He is an Advisory Board Member of the ESGE (European Society for Gynaecological Endoscopy) and member of the Special Interest Group in Robotics. His research interests are focused on minimally invasive surgery (laparoscopic, robotic and hysteroscopic) for endometriosis and endometrial cancer. Dr. Giulia Rovero graduated in Medicine in 2017 at the University of Florence. She is currently a fifth-year resident at the Division of Gynecology and Pathophysiology of Human Reproduction, Bologna, Italy, directed by Prof. Renato Seracchioli. In 2022/23 she spent twelve months at the Lariboisiere Hospital in Paris focusing on gynecologic oncology. She is developing her research activity in collaboration with Dr. Raimondo in the field of minimally invasive surgery for endometrial cancer.    Highlights: In endometrial carcinoma (EC) patients, the rate of sentinel lymph node (SLN) mapping failure ranges from 20% to 25%. Pooled data assessing predictive factors of SLN mapping failure in EC patients undergoing SLN biopsy through the cervical injection of indocyanine green (ICG) are lacking. ICG dose 30 kg/m2, menopausal status, adenomyosis) nor surgical history is significantly associated with SLN mapping failure in EC patients. Deep myometrial invasion, FIGO grade 3, non-endometrioid histotype, and lymphovascular space invasion are not significantly associated with SLN mapping failure in EC patients.

IJGC Podcast
Predictors of SLN Mapping Failure with Diego Raimondo and Giulia Rovero

IJGC Podcast

Play Episode Listen Later Jun 2, 2023 25:33


In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Drs. Diego Raimondo and Giulia Rovero. Dr. Raimondo works as medical director and assistant researcher at the Division of Gynecology and Pathophysiology of Human Reproduction, Bologna, Italy, directed by Prof. Renato Seracchioli. He received his PhD on new technologies for endometriosis surgical removal from the University of Bologna in 2021. He is an Advisory Board Member of the ESGE (European Society for Gynaecological Endoscopy) and member of the Special Interest Group in Robotics. His research interests are focused on minimally invasive surgery (laparoscopic, robotic and hysteroscopic) for endometriosis and endometrial cancer. Dr. Giulia Rovero graduated in Medicine in 2017 at the University of Florence. She is currently a fifth-year resident at the Division of Gynecology and Pathophysiology of Human Reproduction, Bologna, Italy, directed by Prof. Renato Seracchioli. In 2022/23 she spent twelve months at the Lariboisiere Hospital in Paris focusing on gynecologic oncology. She is developing her research activity in collaboration with Dr. Raimondo in the field of minimally invasive surgery for endometrial cancer. Highlights: * In endometrial carcinoma (EC) patients, the rate of sentinel lymph node (SLN) mapping failure ranges from 20% to 25%. * Pooled data assessing predictive factors of SLN mapping failure in EC patients undergoing SLN biopsy through the cervical injection of indocyanine green (ICG) are lacking. * ICG dose 30 kg/m2, menopausal status, adenomyosis) nor surgical history is significantly associated with SLN mapping failure in EC patients. * Deep myometrial invasion, FIGO grade 3, non-endometrioid histotype, and lymphovascular space invasion are not significantly associated with SLN mapping failure in EC patients.

Between Two Lips
Stem Cells and 3D Printing - Advances in Pelvic Health with Professor Caroline Gargett

Between Two Lips

Play Episode Listen Later May 31, 2023 37:31


Professor Caroline Gargett, PhD, is a National Health and Medical Research Council of Australia Leadership Fellow, Women's Health Theme Leader and heads the Endometrial Stem Cell Biology Laboratory at the Hudson Institute of Medical Research and an adjunct Professor in the Department of Obstetrics and Gynaecology, Monash University. She discovered endometrial stem/progenitor cells and investigates their role in endometrial biology, endometriosis and is developing a bioengineered cell-based therapy for treating and preventing Pelvic Organ Prolapse using endometrial mesenchymal stem cells and novel biomaterials. Her awards include the Society for Reproductive Investigation President's Achievement Award (2013), the Endometriosis Foundation of America Honoree (2011), Fellow of the Society for Reproductive Biology (2017) and co-recipient of the $1M Magee Prize for a Vaginal Stem Cells Study She is a Director of the National Stem Cell Foundation of Australia and Stem Cells Limited and Scientific Advisory Board member of the Endometriosis Foundation of America, Fondation Pour la Recherche sur Endometriose, France. She was President of the Australasian Society for Stem Cell Research (2013-2014) and Secretary of the Society for Reproductive Biology (2005-2008). She has authored 155 publications. Currently she is an Editorial Board member of Scientific Reports, Reviewing Board Member for Biology of Reproduction and former Editorial Board Member and Associate Editor for Reproductive Sciences. She previously served as Associate Editor for Fertility and Sterility and Human Reproduction. IMPACT OF OUR POP RESEARCHProf Gargett is developing the first cell-based bioengineered therapy for Pelvic Organ Prolapse (POP) using eMSC and new biomaterials. The impact of the knowledge generated in evaluating their new bioengineered therapy in a rat model of “POP” repair (2014) was the initiation of a new line of research in Urogynaecology. She and now others have progressed her pioneering research to large animal vaginal surgery models of POP, nanotechnologies and 3D (bio)printing. She trained 3 gynaecologists in this new technology, one received 3 International awards, was invited to present at a Gordon Research Conference (2016) and leads a research group in Graz, Austria. She secured 3 CIA NHMRC Project, Investigator & SIEF grants for our POP research and given 14 international invited presentations, including The Royal Society, London (2017) and IUGA Clinical Conference (2020, 2019, 2018, 2022) and was invited to join IUGA Steering Committee to create a Basic Science/Translational Research Special Interest Group and presented in the inaugural IUGA Basic Science Symposium in 2020.*******************I recommend checking out my comprehensive pelvic health education and fitness programs on my Buff Muff AppYou can also join my next 28 Day Buff Muff Challenge https://www.vaginacoach.com/buffmuffIf you are feeling social you can connect with me… On Facebook https://www.facebook.com/VagCoachOn Instagram https://www.instagram.com/vaginacoach/On Twitter https://twitter.com/VaginaCoachOn The Web www.vaginacoach.com

Midday
Dr. Jeffrey Kahn: Ethics and the future of human reproduction

Midday

Play Episode Listen Later May 3, 2023 31:05


Today on Midday on Ethics, a discussion about advancements in technology that change the way humans reproduce. Tom's guest is Dr. Jeffrey Kahn, the director of the Johns Hopkins Berman Institute of Bioethics. He is also Professor in the Dept. of Health Policy and Management of the Johns Hopkins Bloomberg School of Public Health. In a 2016 book, a researcher named Henry Greely predicted that in a few decades, most people will make babies by methods other than sex. And a recent article in The New Yorker from writer Emily Witt looks into the booming,multi-billion-dollar industry that's driving advances in reproductive technologies such as in vitro fertilization, or IVF. And now, IVF may eventually give way to a procedure known as IVG, or in vitro gametogenesis. That's just one of several new methods by which babies can be made, and the reproductive clock for women can be extended. Dr. Jeffrey Kahn joins Tom in Studio A.See omnystudio.com/listener for privacy information.

Huberman Lab
How to Optimize Fertility in Males & Females

Huberman Lab

Play Episode Listen Later Jan 23, 2023 262:14


In this episode, I discuss the mechanisms by which human eggs and sperm are generated, the ovulatory/menstrual cycle, the conception process and overall fertility in males and females. I also explain how, regardless of whether you seek to conceive children, optimizing egg and sperm health is directly related to vitality and longevity. I cover the nutrition-based, behavioral, supplement-based and prescription approaches to optimizing egg and sperm health, the ovulatory/menstrual cycle and fertility. In addition, I explain lifestyle choices that greatly assist or harm fertility—several of which are very surprising. I provide science-based protocols for those trying to conceive children. The tools and principles I discuss can also improve overall vitality and longevity in all people, regardless of age.  For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Maui Nui: https://mauinuivenison.com/huberman Eight Sleep: https://eightsleep.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Fertility, Vitality & Longevity (00:04:24) Maui Nui Venison, Eight Sleep, Momentous (00:08:20) Eggs & Sperm, Genes, Fertilization (00:18:28) Puberty: Gonadotropin Releasing Hormone (GnRH), Melatonin & Leptin (00:23:38) Onset Trends of Puberty, Odors Effects (00:31:24) Female Puberty, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) (00:35:25) AG1 (Athletic Greens) (00:36:34) Ovulatory & Menstrual Cycle (00:40:36) Follicular Phase: Egg Maturation & Ovulation, FSH & Estrogen (00:51:09) Luteal Phase: Progesterone & Estrogen, Menstruation (00:58:14) Ovulation & Libido; Luteal Phase & Malaise; Individual Variability (01:03:14) InsideTracker (01:04:18) Sex Chromosomes, Sperm (01:11:40) Tool: Testicular Temperature & Fertility (01:17:22) Sperm Production, Seminal Fluid, Vasectomy (01:24:07) Sperm Cells, Mitochondria & Motility, Intercourse Frequency & Fertilization (01:28:31) Sperm Production, GnRH, FSH, LH & Testosterone (01:36:21) Ejaculate Quality, Sperm Counts, Fertilization, Ectopic Pregnancy (01:44:14) Tool: Sexual Intercourse Frequency & Fertilization (01:53:24) Tools: Tracking Ovulation, Libido, Lubricants (01:56:42) Fecundability: Egg Quality & Woman's Age, Cumulative Pregnancy Rate (02:08:17) Miscarriages, Chromosomal Abnormalities (02:11:23) Female Fertility: Age, Follicle Testing & Anti-Mullerian Hormone (AMH) Testing (02:18:51) Male Fertility: Sperm Analysis, Age (02:24:52) Fertility & Hormone Analysis, Age (02:29:07) Fertility Effects of Sleep, Cortisol/Stress, Cannabis/Nicotine & Alcohol (02:42:40) Fertility, Sexually Transmitted Infections (STIs), Viral Infection & Cystic Fibrosis (02:47:42) Tool: Testicular Temperature & Fertility (02:51:26) Tool: Phones & Sperm Quality (02:58:06) Deliberate Cold Exposure & Fertility, Testicular Temperature, Cortisol/Stress (03:05:43) Fertility, Exercise & Mitochondrial Health; Intermittent Fasting (03:14:46) Testosterone Replacement Therapy & Sperm Production; Supplements (03:20:36) Sex Determination in Offspring, In Vitro Fertilization (IVF), Sperm Fractions (03:32:23) Postcoital Female Position & Fertilization, Sperm Quality (03:36:57) Cannabis & Sperm Motility, Libido, Pregnancy (03:42:33) Acupuncture, Fertility & Pregnancy (03:49:25) Fertility Supplements: L-Carnitine & Allicin, Coenzyme Q10 (03:56:18) Fertility Supplements: Inositol, Omega 3 Fatty Acids (04:02:50) Supplements for Hormones: Tongkat Ali, Shilajit, Zinc (04:13:02) Fertility & Prescription Medications (04:16:44) Human Reproduction & Fertility (04:20:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Title Card Photo Credit: Mike Blabac

Hypno-WHAT?! Modern Hypnobirthing with Claire.

The Estimated Due Date... that magical day your hit 40 weeks and fully expect your baby to arrive then or shortly after. As does everyone you shared the date with. The texts flood in - Have you had the baby yet? How long are they going to let you go? Get a sweep. Eat 14 pineapples.None of it is ill intended but it can sow the seeds of doubt and have you questioning your body - why hasn't it gone in to labour by now?Well today I'm going to talk you through the due date and why you should pay it as little attention as possible. We're going to talk about focussing on The Due Period rather than a single day, on which less than 5% of babies are born.The Hypno-WHAT Podcast now has it's own instagram page! Give it a follow here to keep track of new episodes as they come out! And if you want to have a nosy at what Claire is up to you can find me here.If instagrams not your thing you can also get in touch via email, my address is claire@birthingparentsclub.com. I really do love hearing from you, so whether it's podcast feedback, episode ideas or your birth story please don't hesitate to drop me a line.I hope you are enjoying the soothing sound of Scotland in your ears as your relax during pregnancy; you can now buy more of my hypnobirthing mp3s on my online shop. They are a bargain £4 each and cover topics such as anxiety, confidence building, fear release & preparing to breastfeed. Check it out here! Or to get yourself booked in for private birth prep with me - available online or face to face in Edinburgh & the surrounding.Your feedback is super important to me - it not only tells the podcast gods & goddesses that you are enjoying the show but it helps me to reach more people, spreading the good word of birth far & wide! If you have a couple minutes to drop me a rating & a few words for a review, I would be so grateful - thank you!References:Bull, J.R., Rowland, S.P., Scherwitzl, E.B. et al. Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles. npj Digit. Med. 2, 83 (2019). https://doi.org/10.1038/s41746-019-0152-7A.M. Jukic, D.D. Baird, C.R. Weinberg, D.R. McConnaughey, A.J. Wilcox, Length of human pregnancy and contributors to its natural variation, Human Reproduction, Volume 28, Issue 10, October 2013, Pages 2848–2855, https://doi.org/10.1093/humrep/det297Support this podcast at — https://redcircle.com/hypno-what-modern-hypnobirthing-with-claire/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

The Gary Null Show
The Gary Null Show - 11.03.22

The Gary Null Show

Play Episode Listen Later Nov 3, 2022 63:51 Very Popular


Videos: Did Julian Assange's lawyers just EXPOSE this CIA scheme? Redacted with Natali and Clayton Morris (3:23 to 6:46) EXCLUSIVE: UNDERTAKER EXPLAINS “MYSTERIOUS” CLOTTING PHENOMENON! | Louder with Crowder (8:17 – 26:00)   Green tea and resveratrol reduce Alzheimer's plaques in lab tests Tufts University, November 2, 2022 Tufts researchers are working to understand what might slow progression of Alzheimer's disease. They have tested 21 different compounds in Alzheimer's-afflicted neural cells in the lab, measuring the compounds' effect on the growth of sticky beta amyloid plaques. These plaques develop in the brains of people with Alzheimer's. The researchers found that two common compounds—green tea catechins and resveratrol, found in red wine and other foods—reduced the formation of plaques in those neural cells. And they did so with few or no side effects. The researchers reported their findings in the journal Free Radical Biology and Medicine. Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents—slowing Alzheimer's induced by the herpes virus. But finding a compound “that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer's, you might still see some kind of improvement,” says Dana Cairns, GBS12. Cairns is a research associate in the Kaplan Lab in the School of Engineering and led the research. The initial screen found five compounds had “really robust prevention of these plaques,” she says. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects. “We hoped to find compounds that would be harmless and show some level of efficacy,” she said. Green tea compounds and resveratrol met that standard. “We got lucky that some of these showed some pretty strong efficacy,” Cairns said. “In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week.” The discovery is significant because there is no cure for Alzheimer's or a way to prevent its progression, aside from several potential drugs developed by pharmaceutical companies that are still in trials, Cairns says. Compounds like these two that show some efficacy and are known to be safe and easily accessible could be taken as a supplement or consumed as part of one's diet, she adds. High fiber, yogurt diet associated with lower lung cancer risk Vanderbilt University Medical School, October 28, 2022 A diet high in fiber and yogurt is associated with a reduced risk for lung cancer, according to a study by Vanderbilt University Medical Center researchers published in JAMA Oncology. The benefits of a diet high in fiber and yogurt have already been established for cardiovascular disease and gastrointestinal cancer. The new findings based on an analysis of data from studies involving 1.4 million adults in the United States, Europe and Asia suggest this diet may also protect against lung cancer. Participants were divided into five groups, according to the amount of fiber and yogurt they consumed. Those with the highest yogurt and fiber consumption had a 33% reduced lung cancer risk as compared to the group who did not consume yogurt and consumed the least amount of fiber. “This inverse association was robust, consistently seen across current, past and never smokers, as well as men, women and individuals with different backgrounds,” she added. Shu said the health benefits may be rooted in their prebiotic (nondigestible food that promotes growth of beneficial microorganisms in the intestines) and probiotic properties. The properties may independently or synergistically modulate gut microbiota in a beneficial way. Yoga Practice Beneficial to Patients With COPD All India Institute of Medical Sciences Oct. 28, 2022 Patients with COPD who practice yoga can improve their lung function, according to a study by researchers at the All India Institute of Medical Sciences, Department of Pulmonary Medicine and Sleep Disorders. The study found that lung function, shortness of breath, and inflammation all showed significant improvement after patients completed 12 weeks of training. An estimated 24 million Americans may have COPD, which includes chronic bronchitis, emphysema, or both. Patients with COPD have trouble pushing used air out of their lungs, making it difficult to take in healthy new air. Although there is no cure for COPD, a patient's quality of life can be improved by controlling symptoms, such as shortness of breath. The study included 29 stable patients with COPD who received yoga training in a format that included the use of physical postures (asanas), breathing techniques (pranayama), cleansing techniques, (kriyas), meditation, and a relaxation technique (shavasan) for 1 hour, twice a week, for 4 weeks. Following the 4-week period, patients were trained for 1 hour every 2 weeks, with the remaining sessions completed at home. Patients were evaluated on assessment of lung function, breathing, quality of life, and inflammation status. A repeat assessment was done at the end of the 12-week training session. All parameters showed significant improvement at the end of the 12-week period. “We found that yoga can be a simple, cost-effective method that can help improve quality of life in patients with COPD,” stated Dr. Guleria. Iron proposed as cause of heart failure in many heart attack patients Indiana University School of Medicine, November 2 2022. A study published in Nature Communications revealed the discovery of a cause for chronic heart failure that occurs in approximately half of the people who experience a heart attack. “For the first time, we have identified a root cause of chronic heart failure following a heart attack,” lead researcher Rohan Dharmakumar of Indiana University School of Medicine's Cardiovascular Institute announced. Using large animal models, the research team found that in heart attacks in which bleeding within the heart muscle occurs upon restoration of circulation, scar tissue is gradually replaced by fat. The inability of fat to effectively propel blood from the heart can lead to heart failure in survivors of this type of heart attack. “Using noninvasive imaging, histology and molecular biology techniques, and various other technologies, we have shown that iron from red blood cells is what drives this process,” Dr Dharmakumar reported. “When we removed the iron, we reduced the amount of fat in the heart muscle. This finding establishes a pathway for clinical investigations to remedy or mitigate the effects associated with iron in hemorrhagic myocardial infarction patients.” The finding led to a clinical trial to determine the effect of iron chelation therapy to remove excess iron in patients with hemorrhagic heart attack. “While advances across populations have made survival after a heart attack possible for most, too many survivors suffer long-term complications like heart failure,” Indiana University's Cardiovascular Institute physician director Subha Raman, MD noted. “Dr Dharmakumar's breakthrough science illuminates who is at risk and why and points to an effective way to prevent these complications.” DHEA supplementation associated with improved sexual function in women Center for Human Reproduction (New York), October 6, 2022 A report published in the journal Endocrine revealed improvements in sexual function among older premenopausal women who supplemented with the hormone dehydroepiandrosterone (DHEA). In their introduction to the article, authors Vitaly A. Kushnir of the Center for Human Reproduction in New York and colleagues describe their use of DHEA in the treatment of infertile women who had low levels of androgen hormones. “In the process of treating thousands of so-affected infertile women, we noticed that many spontaneously reported improvements in libido, sexual desire and, sometimes, even pain status, leading to the paradoxical situation of women refusing to discontinue DHEA supplementation once they conceived,” they remarked. “When we, in a review of the literature, were unable to find a study that investigated the effectiveness of DHEA on female sexuality in older premenopausal women, this study was developed.” The study included 50 infertile premenopausal women whose age averaged 41 years. The participants supplemented with oral DHEA for a minimum of six weeks prior to starting any other fertility treatments. Serum androgen hormone levels, including DHEA and testosterone, were shown to increase following DHEA supplementation. In comparison with pretreatment scores, FSFI index scores improved by 7%, including a 17% increase in desire, a 12% increase in arousal, and an 8% increase in lubrication. However, among women whose scores were among the lowest 25% of the group, total FSFI scores increased by 34%, which included a 40% increase in desire, a 46% increase in arousal, and a 33% increase in lubrication. Women in this group also experienced a 54% increase in orgasm, greater satisfaction, and less pain in comparison with pretreatment values. Trauma during childhood triples the risk of suffering a serious mental disorder in adulthood, study finds Hospital del Mar Medical Research Institute (Spain), November 2, 2022 A study led by researchers at the Hospital del Mar Medical Research Institute links psychological trauma in childhood with an increased risk of developing some kind of mental disorder years later. Suffering psychological trauma during childhood significantly increases the risk of developing a mental disorder in adulthood. Specifically, as much as three times, according to a recent study, published in the journal European Archives of Psychiatry and Clinical Neuroscience. The study analyses the fourteen reviews and meta-analyses published to date in specialized journals on this issue, and is the first to take into account the full range of existing mental disorders. In total, the studies analyzed incorporate more than 93,000 cases, revealing a direct link between suffering psychological trauma at a pediatric age and the risk of developing a mental pathology later in life. “It is the strongest evidence to date that psychological trauma really is a risk factor for suffering a mental disorder later on,” says Dr. Benedikt Amann, lead author of the study The most common childhood traumas are emotional, physical and sexual abuse, as well as emotional or physical neglect and bullying, although there are many others. Suffering one of these situations damages the brain, causing physical as well as psychological consequences in the form of various disorders. In the case of emotional abuse, the most frequent trauma is associated with the most prevalent disorder in the population, that of anxiety. But there is also a relationship between childhood trauma and other pathologies, such as psychosis, which is linked to all traumas, obsessive-compulsive disorder or bipolar disorder. The risk of suffering from borderline personality disorder increases up to fifteen times in the case of having experienced trauma during childhood. Trauma in adulthood is also associated with a four-fold increase in the risk of a later mental disorder. The researchers point out, however, that there is less evidence for this type of pathology.

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