Podcasts about atii

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oin CryptoMom2 as she speaks with the Anti-Human Trafficking Intelligence Initiative team about what you need to know as a company and as an individual to be proactive in supporting change within our community. The Blockchain Legal Institute supports the mission of the Anti-Human Trafficking Intelligence Initiative (ATII). In partnership, we are sharing this information so you can also support the global initiative. The ATII helps financial institutions promote corporate social responsibility through increasing awareness, facilitating intelligence integration & technology advancement, and encouraging strategic data collaboration – to combat human trafficking. To reach them visit https://followmoneyfightslavery.org/. For those interested in learning about blockchain topics, law, internships and free educational digital workshops & summits, visit www.BLI.Tools. By joining www.BLI.Tools with the courtesy code of ATII20. you will benefit from a 20% discount and ATII will receive a donation as well. About Jacqueline Cooper: With a rich background spanning business, education, and law, Jacqueline found her true calling in the realm of creative technology. Her mission is to empower individuals with the knowledge and tools necessary for confident decision-making in this rapidly evolving sector. She is the CEO of the Blockchain Legal Institute (www.BLI.Tools) As the author of 'The Best 5 Minute Crypto Wealth Organizer' and 'The Bitcoin Cinderella & Her Adventures on the Blockchain', the first-ever Web3 fairytale series, Jacqueline beautifully blends the complex world of blockchain with engaging narratives. Not stopping at just writing, she also founded CryptoMom2 Consulting, a comprehensive consultancy firm committed to fostering success within the blockchain industry through education and provision of ongoing resources. Her formidable educational background underpins her expertise: a B.A. from Vassar College (NY), a J.D. from UC Law SF (CA), and an M.A. in Leadership in Teaching from Notre Dame of Maryland University (MD). Moreover, as a National Board Certified Special Education Consultant (NBCT), she has a keen eye for creating inclusive and effective educational experiences. With her unique blend of experiences, Jacqui Cooper is a powerful voice in the world of blockchain and crypto education, constantly pushing boundaries and helping others to do the same. Follow CryptoMom2 here! Instagram: cryptomom2_bitcoincinderella Twitter: @CryptoMom2Show LinkedIn: www.linkedin.com/in/-cooper-jd-cryptomom2-talkshow Unearth the treasures of 'The Bitcoin Cinderella Initiative' by visiting: www.bitcoincinderellashop.com For enlightening reads penned by CryptoMom2, check out: www.bitcoincinderella.com 'The Bitcoin Cinderella' awaits you in English, Spanish, and Creole. Other compelling titles include 'The Bitcoin Cinderella & The 7 Dwarves', 'How To Use Digital Assets To Fundraise For Your Non-Profit', and 'Best 5 Minute Crypto Wealth Organizer: For You, Your Family, Tax Planners & Estate Planning'. Expand your crypto knowledge and join our subscriber community today!

This week, I discuss which patients respond best to ATII and when to start it (hint: it's earlier than you think)Follow HERE! References:All references for Episode 91 are found on my Read by QxMD collectionSupport the showFind ER-Rx: - On Instagram: @ERRxPodcast - On the website: errxpodcast.com - On YouTube Disclaimer: The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.12.523571v1?rss=1 Authors: Iezza, D., Predella, C., NI, K., Murray, J. W., Liu, H.-Y., Saqi, A., Glasser, S. W., Dorrello, N. V. Abstract: Childhood interstitial lung disease (chILD) secondary to pulmonary surfactant deficiency is a devastating chronic lung disease in children. Clinical presentation includes mild to severe respiratory failure and fibrosis. There is no specific treatment, except lung transplantation, which is hampered by a severe shortage of donor organs, especially for young patients. Repair of lungs with chILD represents a longstanding therapeutic challenge but cellular therapy is a promising strategy. As surfactant is produced by alveolar type II epithelial (ATII) cells, engraftment with normal or gene-corrected ATII cells might provide an avenue to cure. Here we used a chILD disease-like model, Sftpc-/- mice, to provide proof-of-principle for this approach. Sftpc-/- mice developed chronic interstitial lung disease with age and were hypersensitive to bleomycin. We could engraft wild-type ATII cells after low dose bleomycin conditioning. Transplanted ATII cells produced mature SPC and attenuated bleomycin-induced lung injury up to four months post-transplant. This study demonstrates that partial replacement of mutant ATII cells can promote lung repair in a mouse model of chILD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The Anti-Human Trafficking Intelligence Initiative (ATII) combats global human trafficking by promoting corporate social responsibility through increasing awareness, facilitating intelligence integration and technology advancement, and encouraging strategic data collaboration. The post 137 Anti human trafficking ATII appeared first on Thoughts On The Social World.

Aaron Kahler is the Founder and CEO of the Anti-human Trafficking Intelligence Initiative (ATII). Contact Aaron: Aaron@followmoneyfightslavery.orgLinks: Main webpage ATII LinkedIn (please like and share!) Red Flags and Indicators Applicable to Sex Trafficking & Forced Labor ATII Video Library Anti-Human Trafficking Retail Consortium Membership Flyer Other ATII Downloadable Resources Full link tree About the ATII:The combination of the ATII team, along with the resources from our many important strategic partners has proven to be successful in combating labor and sex trafficking by hitting slave profiteers where they'll hurt most. We do this by sharing information and reporting activity to combat human trafficking through our relationships with the cryptocurrency community, regulatory officers and law enforcement personnel. We aspire to bring necessary change in the approach to trafficking prevention, detection, reporting, and collaboration to achieve social justice and save lives by disrupting the illicit economics of human trafficking.

ATII stands for the Anti Human Traffiking Intelligence Initiative .http://www.Follow the Money Fight Slavery.org  a non profit organisation promoting corporate responsibility,awareness raising,intelligence integration,technical advancement and data collaboration. Sam Graber is the chief Communications Officer of ATII The post 115 Human Traffiking. Follow the Money. appeared first on Thoughts On The Social World.

Guest of the podcast in episode 23 is Aaron Kahler - the founder of the Anti-Human Trafficking Intelligence Initiative (ATII). Aaron has more than 15 years experience in the Financial Crimes & Regulatory Compliance Advisory space. The Anti-Human Trafficking Intelligence Initiative (ATII) is a nonprofit that encourages financial institutions and companies globally to practice corporate social responsibility and implement anti-human trafficking programs within their organizations (such as policies & procedures, training-live/eLearning, red flags & indicators, high risk trafficking data, and more). The organization addresses gaps in the detection, prevention and reporting of corporations & financial institutions around human trafficking in comparison to how other financial crime prevention is prioritized.  They also have partnerships with Federal, State & local law enforcement in the US, as well as agencies and NGO's to support investigations around trafficking, child exploitation, and missing persons. We are very happy to share with you news about an upcoming event! This January, ATII will organize its first virtual summit.  In this webinar conference, you can hear more from BSA Officers, Financial Crime Investigators, Regulators & more to promote corporate social responsibility through increasing awareness, facilitating intelligence integration and using strategic data collaboration.Reserve your FREE ticket now, and follow ATII on LinkedIn - you can find links in the show notes.Register for the Summit here: https://followmoneyfightslavery.org/SUMMIT/ ; ATII's LinkedIn page: https://www.linkedin.com/groups/1841687/ ;Aaron's LinkedIn page: https://www.linkedin.com/in/aaronmkahler/ ATII's Blog: https://followmoneyfightslavery.org/blog/

In Part 2 of this "Mini Grand Rounds" series, we discuss important side effects of ATII including thrombosis, especially in the setting of COVID. References:Celi A, Cianchetti S, Dell'Omo G, Pedrinelli R. Angiotensin II, tissue factor and the thrombotic paradox of hypertension. Expert Review Cardiovasc Therapy. 2010. 8 (12)Senchenkova EY, Russell J, Almeida-Paula LD, et al. Angiotensin II-mediated microvascular thrombosis. Hypertension. 2010; 56 (6): 1089-1095Zhang P, Zhu L, Cai J, et al. Association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circ Res. 2020: 126 (12): 1671-1681Tralhao A, Moita LF, Povoa P. Potential benefits of angiotensin II in COVID-19 patients: beyond reasonable doubt? Crit Care. 2020; 243 (324)Zangrillo A, Landoni G, Beretta L, et al. Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series. Crit Care. 2020; 24: 227Want H, Das S, Wieruszewski PM, et al. Unexpected BP sensitivity to angiotensin II in a patient with coronavirus disease 19, ARDS, and septic shock. CHEST. 2020; 158 (2): e55-58

Guarantee of More Blessing to ComeEphesians 1:13-14 August 9, 2020 I. Introduction:A. I love things that come with a guarantee, especially if it is a lifetime guarantee.1. For example, I had a foundation crack in our house fixed many years ago andthe person who did it gave me a lifetime guarantee to fix it if it ever happenedagain. It did happen again a few years ago, I gave him a call and he cameand fixed it at no cost.2. There are all kinds of guarantees, both those that protect us from anythinghappening to what we have – those give us a sense of security and guaranteesthat promise us that there is something we will get in the future – they give usa sense of assurance and hope.3. In one sense, a down payment on a loan is a guarantee that I give to the bank.A sizable amount of money given to the bank to show my seriousness inpaying the rest! It is the first installment of more payments to come!B. This kind of guarantee are pledges! Sometimes pledges can be made with ourwords as we solemnly promise to do something, sometime pledges carry evenmore weight as you give something to someone as a way to show that you willkeep your promise!1. Bill Chibe, who works in banking and mortgages, said to me that they refer toa down payment as a person having “skin in the game!”2. Today’s passage teaches us God has given us something as a pledge, His wayto show us that He will keep all His other promises to us!3. Turn in your Bibles to Ephesians 1:13-14C. The structure of the passage is very simple1. v13 tells us what happened to us, what God did to us when we first believedthe gospel message and put our faith in Jesus Christ2. v14 tells us why this happened to us D. Before I read this passage, I am going to tell you what I believe the heart of thiswhole passage says, “The blessing of the Holy spirit guarantees more blessing tocome!”1. Repeat! You repeat with me! Now say it as if you were going to preach it!2. Read!• Let’s start by looking atII. The blessing of the Holy SpiritA. Again we see at the start of this verse that what follows took place when we putour faith in the gospel message about Jesus ChristB. What happened is we were sealed in Christ!1. We seal things all kinds of different things all the time – for instance watchme seal this envelope!2. To seal something means to close something to make it secure and tamperproof. Often back then, when they sealed something there was a symbol ofwho was doing the sealing to identify them as the owner of what was in thething sealed!3. We have been sealed in Christ with the Holy Spirita) Illustrate with envelope – Jesus, piece of paper – believer - seal – HolySpiritb) We are now enclosed in Christ, secure and tamper proof because theHoly Spirit is the seal, an indication that God owns us!C. Note at the end here it says the Holy Spirit of promise1. In the Old Testament, many promises were made about the day when HolySpirit would come and live in God’s people. We especially see that in thenew covenant in Ezekiel 36 where He says He will give them a new heart anda new spirit to live inside of that heart.2. Jesus referred to these promises in Luke 24:49 when he spoke to His disciplesabout the coming of the Holy Spirit upon them soon.D. What a gift, what a blessing the Holy Spirit is to us: He indwells us so thepresence of God is right inside of us, He is the one through whom God fills ourlives with love, joy, peace, patience, kindness, goodness, gentleness, faithfulnessand self-control. He leads us, restrains us, breaks down the work of the flesh inlives and fills us with the resurrected life of Jesus. He equips us with everything we need to do god’s will in a way that is pleasing to him. The list goes on and on.The promise of the Holy Spirit is truly a huge blessing in our lives!• So the blessing of the Holy Spirit is God’sIII. Guarantee of more blessings to come!A. Read v14aB. He is given as a pledge! We already talked about that in the intro to this message.The Holy Spirit is God’s guarantee, His first instalment, His down payment, Hispledge, and His skin in the game!C. But what is He a pledge of? Our inheritance1. Reread v14a2. In particular our future inheritance. Read 14a-c “with a view to”D. Let me remind you of three things we have already learned as we put this part ofthe verse together!1. Inheritance – we learned last week that bottom line our inheritance is made ofall of God’s blessings that He has promised to us! –a) That is why the word promise is so important in v13b) The Holy Spirit was the first of many more promises yet to come! Ourfuture promised blessings!2. Redemption –a) We learned that there are three aspects to redemption – someone is inbondage, a price is paid and the result of this is someone is deliveredfrom that bondageb) We also learned there is a past, present and future aspect to ourredemption – past – set free from the penalty of sin, present – set freefrom the power of sin, future set free from the – presence of sinc) This passage is talking about our future deliverance from the presence ofsin in our bodies and our environment3. The third thing we learned just a few minutes ago was that a seal is a sign ofownership - read v14d – that’s us!E. So as I reread these verses note that, “the blessing of the Holy Spirit guaranteesmore blessing to come!” Read v13-14a-c F. So why has God blessed us with the Holy Spirit? Why is He guaranteeing thesefuture blessings? Why is He going to bless us in the future? Why all thesepromises? Why all these blessings? Why all this inheritance?1. Read 14d and read 2:72. This is all about God’s grace, the great glory of His grace, and bringingpraise to Him because of it!3. Last week it talked about our being, our entire existence and everything weare and do being to the praise of His glory. Here it talks about us praisingGod.4. This section of spiritual blessings starts with saying the very nature of Goddemands that we bless and praise Him especially for all the spiritual blessingsHe has given us in Christ. Now He closes this section with telling us that allof this is so we will praise the glory of His grace. • So to prepare us to praise God. Let meIV. Remind us of these promised blessings the Holy Spirit guarantees for us!A. Read 1 Peter 1:3-5 1. In the future when we receive this inheritance, when we are delivered fromthe presence of sin both in our bodies and in our environment. When weexperience all of God’s future promised blessing. Listen to my summary ofwhat life will be like as I try to summarize the heart of Scripture regardingthis!2. In the eternal aspect of the kingdom in the new heaven and new eartha) There will be no more funerals graveyards, or tearful goodbyes, no moreemotional pain and depression over rejection, separation, abuse or loss.No more hospitals or cancer or deformities or diseases, no more migraineheadaches or need for painkillers and no more health insurance. Nomore food pantries or food stamps. No more sin to affect people, theirrelationships, their work or the earth. The earth will be fully productiveand beautiful.b) That means we will never again suffer persecution, mocking or conflictof beliefs or values with those who are unbelievers. Nothing shameful,vile, detestable, unpleasant will be there, no news reports telling us aboutmurders that happened in the big cities, we can walk the streets safely and without fear. No more adultery, rape or sexual abuse, no moredemonic influence through witchcraft or drugs. You can trust anythingand everything that is said. There will be no shaky deals ormisrepresentations. God will be the greatest love of everyone that isthere. No one will ever put anything or anyone above God and His willfor them. They will love Him with all their heart, all their soul, all theirmind and strength, and they will love their neighbor as themselves.B. This is what receiving the Holy Spirit guarantees for us! Let’s praise the glory ofGod’s grace!

Mange går rundt med litt høyt blodtrykk, og trenger behandling for å redusere dette. Ta vanlige grupper medisiner som gjør dette, virker på samme system som kalles renin-angiotensin-aldosteron-systemet, eller RAAS. Hva er så alt dette?

Author: Aaron Lessen, M.D. Educational Pearls Icatibant was introduced to treat ACE-inhibitor induced angioendema. This type of angioedema is refractory to epinephrine and antihistamines, and is likely mediated by elevated bradykinin.(which is inactivated by ATII and ACE). Icatibant initially was shown to reduce facial swelling and airway obstruction in the setting of ACE-I angioedema, but later, better-powered studies showed that it had no benefit compared to standard treatment. References: Sinert R et al. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. J Allergy Clin Immunol Pract 2017. PMID: 28552382  

Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible loss of lung function and is one of the most prevalent and severe diseases world-wide. A major feature of COPD is emphysema- a long-term, progressive condition. The hallmark of emphysema includes the destruction of alveolar structures leading to enlarged air spaces and reduced surface area. Experimental evidence suggests that emphysema development is driven by accelerated senescence of lung cells but the underlying mechanism of senescence is yet to be fully elucidated. Protein arginine methyltransferases (PRMTs) are important for cellular processes, such as the regulation of senescence, cell proliferation, differentiation and apoptosis. The PRMT family includes 11 members classified as type I, II or III enzymes depending on their methylation pattern (asymmetric dimethylation, symmetric dimethylation or monomethylation, respectively). One member of this family is PRMT4, a type I enzyme, which is also called coactivator associated arginine methyltransferase 1 (CARM1). It was originally identified as a coactivator for steroid hormone receptors. CARM1 is known to methylate histone H3 and various non-histone proteins that play essential roles in transcriptional regulation, RNA splicing, and metabolism. Most importantly, complete loss of CARM1 leads to disrupted differentiation and maturation of alveolar epithelial type-II cells (ATII). Furthermore, CARM1 also plays a role in regulating cellular senescence via CARM1-dependent methylation. Based on these reports, we hypothesized that CARM1 regulates the development and progression of emphysema. To address this, we investigated the contribution of CARM1 to alveolar rarefication using the mouse model of elastase-induced emphysema in vivo and siRNA-mediated knockdown in ATII-like LA4 cells in vitro. We monitored emphysema progression for 161 days in mice treated with a single oropharyngeal application of elastase. The progression was manifested by the decline in lung function parameters. The mean chord length (Lm) confirmed a time dependent airspace enlargement and was directly correlated with a significant increase in dynamic lung compliance. We also observed that at later time points (day 56 and 161), emphysema progression was inflammation-independent. We demonstrated that emphysema advancement was associated with a time-dependent downregulation of CARM1, specifically in alveolar epithelial cells. Furthermore, the global CARM1 activity was also reduced as reflected by an elevated level of CARM1 phosphorylation in the lung. Most importantly, elastase-treated CARM1 haploinsufficient mice showed significantly increased airspace enlargement (52.5±9.6 µm vs. 38.8±5.5 µm, p

Background: Idiopathic Pulmonary Fibrosis (IPF) is an unresolved clinical issue. Phosphodiesterases (PDEs) are known therapeutic targets for various proliferative lung diseases. Lung PDE6 expression and function has received little or no attention. The present study aimed to characterize (i) PDE6 subunits expression in human lung, (ii) PDE6 subunits expression and alteration in IPF and (iii) functionality of the specific PDE6D subunit in alveolar epithelial cells (AECs). Methodology/Principal Findings: PDE6 subunits expression in transplant donor (n = 6) and IPF (n = 6) lungs was demonstrated by real-time quantitative (q)RT-PCR and immunoblotting analysis. PDE6D mRNA and protein levels and PDE6G/H protein levels were significantly down-regulated in the IPF lungs. Immunohistochemical analysis showed alveolar epithelial localization of the PDE6 subunits. This was confirmed by qRT-PCR from human primary alveolar type (AT)II cells, demonstrating the down-regulation pattern of PDE6D in IPF-derived ATII cells. In vitro, PDE6D protein depletion was provoked by transforming growth factor (TGF)-beta 1 in A549 AECs. PDE6D siRNA-mediated knockdown and an ectopic expression of PDE6D modified the proliferation rate of A549 AECs. These effects were mediated by increased intracellular cGMP levels and decreased ERK phosphorylation. Conclusions/Significance: Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D and PDE6G/H subunits in IPF lungs and characterize the functional role of PDE6D in AEC proliferation.

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterised by accumulation of activated (myo)fibroblasts and excessive extracellular matrix deposition. The enhanced accumulation of (myo)fibroblasts may be attributed, in part, to the process of transforming growth factor textgreekb1 (TGFtextgreekb1)-induced epithelial--mesenchymal transition (EMT), the phenotypic switching of epithelial to fibroblast-like cells. Although alveolar epithelial type II (ATII) cells have been shown to undergo EMT, the precise mediators and mechanisms remain to be resolved. The objective of this study is to investigate the role of SNAI transcription factors in the process of EMT and in IPF.Methods: Using quantitative reverse transcription-PCR (RT-PCR), immunofluorescence, immunohistochemistry, western blotting, as well as gain- and loss-of-function studies and functional assays, the role of SNAI1 and SNAI2 in TGFtextgreekb1-induced EMT in ATII cells in vitro was assessed; and the expression of SNAI transcription factors was analysed in experimental and human IPF in vivo.Results: TGFtextgreekb1 treatment increased the expression and nuclear accumulation of SNAI1 and SNAI2, in concert with induction of EMT in ATII cells. SNAI overexpression was sufficient to induce EMT, and small interfering RNA (siRNA)-mediated SNAI depletion attenuated TGFtextgreekb1-induced ATII cell migration and EMT. SNAI expression was elevated in experimental and human IPF and localised to hyperplastic ATII cells in vivo.Conclusions: The results demonstrate that TGFtextgreekb1-induced EMT in ATII cells is essentially controlled by the expression and nuclear translocation of SNAI transcription factors. Increased SNAI1 and SNAI2 expression in experimental and human IPF in vivo suggests that SNAI-mediated EMT may contribute to the fibroblast pool in idiopathic pulmonary fibrosis.