Podcasts about Sepsis

Sepsis: Detect. Treat. Survive.   Sepsis remains a major global health threat, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Early recognition, prompt antibiotics, and timely hemodynamic support save lives. ⏱️

Send a textIn this episode of Journal Club, Ben and Daphna review a retrospective cohort study from Pediatrics examining antibiotic duration for uncomplicated Gram-negative bloodstream infections in the NICU. The study, a collaboration between Nationwide Children's Hospital and UT Health San Antonio, compares outcomes between short course (≤8 days) and long course (≥9 days) therapy. The hosts discuss the startling finding that while recurrence rates were similar, the long-duration group had a 14% rate of developing multi-drug resistant (MDR) infections within 90 days, compared to 0% in the short-duration group.----Duration of Antibiotic Therapy for Gram-Negative Bloodstream Infections in the Neonatal Intensive Care Unit. Djordjevich CJ, Magers J, Cantey JB, Prusakov P, Sánchez PJ.J Pediatr. 2026 Jan 17:114993. doi: 10.1016/j.jpeds.2026.114993. Online ahead of print.PMID: 41554433 Free article.Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Samy ist zurück aus dem Urlaub und der erste Dienst startet direkt mit Chaos. Wir feiern zehn Jahre Rettungsdienst und klären eure Fragen. Kann man diesen Job wirklich bis zur Rente durchhalten? Warum fehlen in Hamburg wichtige Medikamente auf dem Rettungswagen? Wir besprechen außerdem einen tragischen Fall von Sepsis nach einer Geburt. Bitte beachtet dazu die Triggerwarnung in der Folge. Zum Schluss gibt es eine witzige Geschichte über einen schlafenden Kollegen im Einsatz. Macht bei unserer Umfrage mit unter retterview.de/umfrage26 Werbung & Support Shopify kostenlos testen: Baue schnell und einfach deinen eigenen Online-Shop und verkaufe über Website, Social Media und Marktplätze → https://www.shopify.de ———

Sepsis: Was hat es mit der neuen Pflichtfortbildung auf sich und was sagt die neue Leitlinie?

In this episode of the Word On Health Podcast, Paul Pennington talks to Consultant neurologist,  Ed Jabbari about PSP & CBD. Dr Ron Daniels joins Paul to talk about Sepsis and, in the final part of this edition,  Paul speaks to Professor Liz Hughes, Medical Director of the cholesterol charity, HEART UK. Support the show

„Bei Sepsis ist nicht die eigentliche Verletzung oder ein Keim das Problem – sondern eine außer Kontrolle geratene Abwehrreaktion des Immunsystems.“ – Sepsis zählt zu den häufigsten Todesursachen weltweit. Jährlich kommt es zu rund 166 Millionen Fällen – über 20 Millionen Menschen sterben daran. Auch in Deutschland sind es jedes Jahr etwa 200.000 Todesfälle, die mit einer Sepsis in Verbindung stehen. Das fatale: Trotz moderner Intensivmedizin wird Sepsis häufig noch immer zu spät erkannt. Was viele als „Blutvergiftung“ bezeichnen, beginnt oft unscheinbar: eine Lungenentzündung, ein Harnwegsinfekt, eine Operation, eine Wunde. Der Körper reagiert mit Entzündung – genau so, wie er es soll. Doch wenn die Balance des Immunsystems zwischen Angriff und Kontrolle kippt, eskaliert das System. Entzündungsbotenstoffe werden massenhaft freigesetzt. Gefäße werden undicht. Der Blutdruck fällt. Mikrogefäße verstopfen. Organe erhalten nicht mehr ausreichend Sauerstoff. Nicht der Erreger richtet den entscheidenden Schaden an – sondern die überschießende Immunreaktion selbst. Sepsis kann sich innerhalb weniger Stunden dramatisch entwickeln. Warnzeichen sind Fieber oder Untertemperatur, Verwirrtheit, schnelle Atmung, Blutdruckabfall oder ein plötzlich stark verschlechterter Allgemeinzustand. Oft entsteht das Gefühl: „Etwas stimmt überhaupt nicht mit mir.“ Und genau das kann lebensentscheidend sein. Selbst nach überstandener Akutphase können Erschöpfung, Muskelschwäche, kognitive Probleme oder eine erhöhte Infektanfälligkeit zurückbleiben – das sogenannte Post-Sepsis-Syndrom. Und das kann ein Leben lang für erhebliche gesundheitliche Probleme und Beeinträchtigungen sorgen. Podcast-Host Felix Moese und Gesundheitswissenschaftler Matthias Baum klären in dieser artgerecht HEALTH NERDS Episode die wichtigsten Fragen: Was genau ist eine Sepsis – und wie unterscheidet sie sich von einer „normalen“ Infektion oder Blutvergiftung? Was passiert im Körper, wenn das Immunsystem außer Kontrolle gerät? Welche Warnzeichen sollte jeder kennen – und ab wann ist es ein Notfall? Wer gehört zu den größten Risikogruppen – und warum? HEALTH NERDS. Mensch, einfach erklärt. Spare 15% auf Deine erste Bestellung auf https://artgerecht.com mit dem Code: HEALTHNERDS15 (im Warenkorb eingeben) Ein ALL EARS ON YOU Original Podcast.

Professor Simon Finfer AO, a global leader in sepsis research and he heads up the Sepsis Research Program at The George Institute, joined Philip Clark on Nightlife.

In this episode of the Pre-Hospital Care Podcast, we're joined by Dr Ron Daniels BEM, one of the most influential voices in the global fight against sepsis. Ron is an NHS Consultant in Intensive Care in Birmingham, the Executive Director of the UK Sepsis Trust, and a key member of the Executive Board of the Global Sepsis Alliance. His work has played a central role in shaping national and international policy, including the WHO's landmark 2017 Resolution on Sepsis.Ron's passion lies in translational medicine, turning evidence into practical actions that save lives. He led the team behind the Sepsis 6, a pathway that has transformed early recognition and treatment across the UK. Thanks to these efforts, more than 80% of patients with suspected sepsis in England now receive timely antimicrobials. Yet challenges remain: striking a balance with antimicrobial stewardship, navigating the intricacies of early shock physiology, and recognising that sepsis in the field is often subtle, evolving, and easily missed.In this conversation, we'll explore how pre-hospital teams can recognise sepsis earlier, act decisively, and integrateseamlessly into wider systems of care. From red flags to real-world barriers, from fluids to future pathways, this episode is packed with essential insights for frontline clinicians.The views and opinions expressed in this podcast are those of the individual speakers and do not necessarily reflect the views, policies, or positions of any affiliated organisations, employers, professional bodies, or regulatory authorities.The content discussed is intended for educational and informational purposes only. It does not constitute medical advice, clinical guidance, or a substitute for formal training, local protocols, or independent clinical judgment.Clinical decisions should always be made in accordance with current evidence, local guidelines, scope of practice, and consultation with appropriately qualified healthcare professionals. Listeners are responsible for ensuring that any application of information discussed is appropriate to their own clinical context.This Podcast is sponsored by World Extreme Medicine.World Extreme Medicine provides internationally recognised education for clinicians and operators working in pre-hospital, remote, expedition, humanitarian, and high-risk environments. Their programmes focus on practical, experience-led learning, equipping professionals with the skills to make sound clinical and operational decisions when resources are limited, evacuation is delayed, and conditions are extreme.With courses covering expedition and wilderness medicine, hostile environments, dive medicine, human performance, leadership, and austere care, World Extreme Medicine brings together a global faculty with real-world experience from some of the most challenging settings on earth. To explore courses, free educational resources, and upcoming webinars, visit: ⁠www.worldextrememedicine.com

In this episode we're hearing from Eleanor about her first pregnancy and birth during lockdown. Having learned lots about birth from her midwife sister and planning for a homebirth, her estimated due date came and went with no sign of labour starting. At nearly 42 weeks she accepted an induction and was able to return home to wait for things to begin. When her contractions became regular, Eleanor and her husband went to the midwife-led unit where she laboured in the pool until concerns were raised about meconium in her waters. After an epidural, a period of rest and infection concerns for both mum and baby, a caesarean was recommended. Eleanor shares the challenges their family faced in the weeks that followed, including being separated from her baby after the birth, navigating visiting hours, pumping and breastfeeding in the NICU and Enid's recovery at home on oxygen. This is a fascinating and really valuable episode about navigating the unexpected and staying strong and positive through it all.   Eleanor's IG: https://www.instagram.com/elebusing/  My website: www.serenalouth.com My IG: https://www.instagram.com/serenalouth/

Noch immer zählt eine Sepsis zu den häufigsten Todesursachen in Deutschland. Ein riesiger Fortschritt im Kampf gegen bakterielle Infektionen waren Penicillin-Antibiotika.

Morse code transcription: vvv vvv Island near Portmeirion is for sale but you may need waders to reach it Macron urges Europe to start acting like world power Chappell Roan leaves talent agency led by Casey Wasserman after Epstein fallout British Museum to keep pendant linked to Henry VIII after campaign Munich Security Conference Trumps world order hangs over Europe Instagram and YouTube owners built addiction machines, trial told More solar farms on the way after record renewables auction Sepsis mistakes killed our daughter we fear it could happen again Ghislaine Maxwell refuses to answer questions about Epstein from Congress Izabela Zablocka death Skilled butcher guilty of murdering, cutting up and burying partner

Morse code transcription: vvv vvv Izabela Zablocka death Skilled butcher guilty of murdering, cutting up and burying partner British Museum to keep pendant linked to Henry VIII after campaign Instagram and YouTube owners built addiction machines, trial told Macron urges Europe to start acting like world power Island near Portmeirion is for sale but you may need waders to reach it Chappell Roan leaves talent agency led by Casey Wasserman after Epstein fallout Munich Security Conference Trumps world order hangs over Europe Sepsis mistakes killed our daughter we fear it could happen again More solar farms on the way after record renewables auction Ghislaine Maxwell refuses to answer questions about Epstein from Congress

Morse code transcription: vvv vvv Munich Security Conference Trumps world order hangs over Europe More solar farms on the way after record renewables auction Instagram and YouTube owners built addiction machines, trial told Ghislaine Maxwell refuses to answer questions about Epstein from Congress British Museum to keep pendant linked to Henry VIII after campaign Chappell Roan leaves talent agency led by Casey Wasserman after Epstein fallout Sepsis mistakes killed our daughter we fear it could happen again Island near Portmeirion is for sale but you may need waders to reach it Macron urges Europe to start acting like world power Izabela Zablocka death Skilled butcher guilty of murdering, cutting up and burying partner

Morse code transcription: vvv vvv Macron urges Europe to start acting like world power Chappell Roan leaves talent agency led by Casey Wasserman after Epstein fallout Ghislaine Maxwell refuses to answer questions about Epstein from Congress More solar farms on the way after record renewables auction Sepsis mistakes killed our daughter we fear it could happen again Munich Security Conference Trumps world order hangs over Europe Izabela Zablocka death Skilled butcher guilty of murdering, cutting up and burying partner Instagram and YouTube owners built addiction machines, trial told Island near Portmeirion is for sale but you may need waders to reach it British Museum to keep pendant linked to Henry VIII after campaign

PJ talks to Doireann O'Mahony of the Irish Sepsis Foundation who give us common and some less common signs of sepsis and reminds us never be afraid to ask Is It Sepsis? See also sepsisfoundation.ie Hosted on Acast. See acast.com/privacy for more information.

Pyritz, Lennart; Gründling, Matthias www.deutschlandfunk.de, Sprechstunde

Send us a textEstamos quase chegando no Carnaval, por isso esse episódio traz a diversificação do desfile de uma escola de samba. Vem com a gente atravessar essa Sapucaí de conhecimento!1.     Hepatitis B Vaccination at Birth: Safety, Effectiveness, and Public Health Benefit - https://pubmed.ncbi.nlm.nih.gov/41639943/2.     Desaturations with or without Bradycardia are Associated with Cerebral and Abdominal Hypoxemia: Secondary Analysis of a Randomized Clinical Trial - https://pubmed.ncbi.nlm.nih.gov/41615858/3.     American Academy of Pediatrics 2022 phototherapy thresholds reduce the hospitalizations and the associated costs - https://pubmed.ncbi.nlm.nih.gov/41591975/4.     Clinical Signs Associated With Mortality and Sepsis in Young Infants A Systematic Review and Meta-Analysis - https://jamanetwork.com/journals/jamapediatrics/article-abstract/2844622 Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Dr. Michael Lanspa chats with Dr. Natasha Spottiswoode and Chaz Langelier about their article, "Host-Microbe Multiomic Profiling Predicts Mortality in Sepsis."

🧭 REBEL Rundown 🗝️ Key Points 💉 Hydrocortisone Saves Lives:The 2023 Cape Cod Trial (NEJM) showed a clear mortality benefit and reduced need for intubation in severe CAP patients treated with hydrocortisone.📊 Guidelines Are Catching Up:The SCCM (2024) and ERS now recommend steroids for severe CAP, while ATS/IDSA updates are still pending.🔥 Redefining “Severe”:Patients requiring high FiO₂ (>50%), noninvasive or mechanical ventilation, or PSI >130 meet criteria for steroid therapy — even outside the ICU.🍬 Main Risk = Hyperglycemia:Elevated glucose was the most consistent adverse effect, but rates of GI bleed and secondary infection were not increased.🧭 Early, Targeted Use Matters:Start hydrocortisone within 24 hours of identifying severity — especially in patients with high CRP (>150) or strong inflammatory response. Click here for Direct Download of the Podcast. 📝 Introduction Corticosteroids have long sparked debate in the treatment of bacterial pneumonia — once viewed with skepticism, now increasingly supported by high-quality evidence. In this episode, Dr. Alex Chapa joins the REBEL Core Cast team to explore how the 2023 Cape Cod Trial (NEJM) reshaped practice and guideline recommendations for severe community-acquired pneumonia (CAP). 📖 Historical Context & Long-Standing Skepticism For decades, the use of steroids in pneumonia was controversial.Early Use: Steroids entered practice in the 1940s and 50s for autoimmune inflammation, but there was immediate hesitation regarding secondary superinfections.Mixed Data: From the 1980s to the 2000s, small studies emerged on severe pneumonia and ARDS, but the data was inconsistent. Different trials used varying definitions of “severe” pneumonia and different C-reactive protein (CRP) cutoffs, making the data “spread” and easy to “cherry pick” to support or deny a benefit.Past Guidelines: This uncertainty was reflected in official guidelines:2007 (ATS/IDSA): The American Thoracic Society and the Infectious Diseases Society of America did not address the topic due to insufficient data.2019 (ATS/IDSA): Pre-COVID, the guidelines recommended against using corticosteroids in severe CAP. They acknowledged no benefit for non-severe pneumonia, but the data for severe pneumonia was considered too weak to endorse.Pre-Trial Consensus: Prior to 2023, the consensus was to avoid steroids in non-severe pneumonia, while severe pneumonia remained a “gray area” with no treatment showing a clear mortality difference. 📜 The Landmark Cape Cod Trial (NEJM 2023) The Cape Cod trial, published in the New England Journal of Medicine in 2023, reignited the discussion by providing robust, positive data.Trial Design: Phase 3, multi-center, double-blind, randomized, controlled trial.Intervention: 800 patients randomized to two groups, Hydrocortisone as a continuous infusion (200mg/day) versus a placebo infusion.Taper: On day 4, clinicians would decide whether to continue the infusion or begin a taper based on clinical response.Population: Patients with severe CAP, defined by meeting at least one of the following criteria:Pneumonia Severity Index (PSI) > 130.O2 by FiO2 ratio < 300.Need for mechanical or non-invasive ventilation (with PEEP ≥ 5).Need for high FiO2 (>50%) via non-rebreather or heated high flow.Primary Outcomes: Death for any cause 6.2% (hydrocortisone) vs 11.9% (placebo)Secondary outcomes:Death from any cause at 90 days 9.3% (hydrocortisone) vs 14.7% (placebo)Endotracheal intubation 18% (hydrocortisone) vs 29% (placebo)Hospital-acquired infections 9.8% (hydrocortisone) vs 11.1% (placebo)Gastrointestinal bleeding 2.3% (hydrocortisone) vs 3.3% (placebo)Vasopressor initiation by day 28 15.3% (hydrocortisone) vs 25.0% (placebo)Key Findings: The trial demonstrated superiority for hydrocortisone 📋 Updated Guidelines & Current Practice The Cape Cod trial, along with subsequent meta-analyses, has begun to change official recommendations.Society of Critical Care Medicine (SCCM): In 2024, an SCCM expert panel, reviewing the Cape Cod trial and 18 others, strongly recommended corticosteroids for severe CAP. They concluded that steroids reduce mortality and the need for mechanical ventilation.Meta-Analysis (Smit et al.): A 2024 meta-analysis in Lancet Respiratory confirmed the 30-day mortality benefit.European Respiratory Society (ERS): The ERS has issued a recommendation to use steroids for severe pneumonia but still urges caution regarding side effects.ATS/IDSA: As of the podcast recording, the ATS/IDSA had not yet updated their 2019 guidelines. 🛠️ Practical Application for Clinicians Defining “Severe” CAP: The key is to identify patients who qualify as “severe”. This can be done using:Scoring Tools: The PSI is the best validated tool for mortality but is cumbersome. Simpler tools like CURB-65 or SMART-COP are practical and acceptable for defining severity. 2023 meta-analysis from by Zaki et al showed both work well, but CURB-65 has better mortality prediction early on.Cape Cod Criteria: Any patient meeting the trial’s inclusion criteria (e.g., high-flow O2, non-invasive ventilation) qualifies, regardless of location (ED, floor, or ICU).Biomarkers: While not required, a CRP level was used in many studies. A CRP > 150 (Cape Cod) or > 204 (Smit meta-analysis) strongly indicates severe inflammation that would benefit from steroids.Clinical Judgment: A patient who looks “sick,” has “soft” blood pressure, or has dense infiltrates and high oxygen needs (e.g., >50% FiO2 on high flow) is a candidate.Adverse Effects:Hyperglycemia: This was the most significant risk identified, with rates between 6-12%. This is a primary concern, especially in patient populations with high BMI.GI Bleed & Secondary Infection: Fears of these side effects, which contributed to historical skepticism, were not borne out in the Cape Cod trial. The data does not support being overly concerned.Other Side Effects: Mood changes, delirium, insomnia, and agitation in the elderly are known side effects of steroids that were not specifically addressed in the trial but remain clinical concerns. 🔄 Clinical Pathway for Steroids in Severe CAP Unanswered Questions & Future Research Possible remaining questions:Biomarkers: Can we find a more precise CRP level to distinguish moderate from severe disease? Could other markers like ferritin or IL-6 be used? Dosing & Tapering: How much immunomodulation is needed, and when is it truly safe to taper?Gender Differences: Early data suggests females may respond better to steroids and experience fewer side effects. The question of female patients with severe CAP require less corticosteroids needs further exploration. 👉 Clinical Bottom Line The current literature, spearheaded by the Cape Cod trial, now supports the use of corticosteroids in severe community-acquired pneumonia. The best evidence currently points to hydrocortisone, started early (within 24 hours) after severity is identified using a validated tool. While hyperglycemia is a risk, the previous fears of GI bleeding and secondary infections were not substantiated in recent, rigorous trials. 📚 References Chapa-Rodriguez A, Abou-Elmagd T, O’Rear C, Narechania S. Do patients with severe community-acquired bacterial pneumonia benefit from systemic corticosteroids?. Cleve Clin J Med. 2025;92(10):600-604. PMID: 41033846Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;388(21):1931-1941. PMID: 36942789Chaudhuri D, Nei AM, Rochwerg B, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e233. PMID: 38240492 Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Alex Chapa, MD PGY 5 Pulmonary Critical Care Fellow Cape Fear Valley Medical Center Fayetteville NC 🔎 Your Deep-Dive Starts Here REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia Corticosteroids have long sparked debate in the treatment of bacterial ... Thoracic and Respiratory Read More The post REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia appeared first on REBEL EM - Emergency Medicine Blog.

In dieser Folge spreche ich mit Prof. Wolfram Ruf, einem der international führenden Forscher auf dem Gebiet der Thromboinflammation. Er ist wissenschaftlicher Direktor des Zentrums für Thrombose und Hämostase am Center for Healthy Aging der Universitätsmedizin Mainz. Wir sprechen darüber, wie Blutgerinnung, Entzündung und Immunsystem miteinander verflochten sind – und warum diese Prozesse im Alter aus dem Gleichgewicht geraten können. Herzinfarkt, Schlaganfall, Krebs, Sepsis oder Covid-19 lassen sich aus dieser Perspektive neu verstehen. Professor Ruf erklärt, wie grundlegende Mechanismen der Blutgerinnung ursprünglich schützen, im Alter aber krankheitsfördernd wirken können – und welche neuen therapeutischen und präventiven Ansätze sich daraus für Healthy Longevity ergeben.In dieser Folge sprechen wir u.a. über folgende Themen: • Wie sind Blutgerinnung und Entzündung biologisch miteinander verknüpft?• Warum steigt das Risiko für Thrombosen mit zunehmendem Alter?• Was genau versteht man unter dem Begriff Thromboinflammation?• Wie entsteht ein Herzinfarkt aus gestörter Blutgerinnung und Entzündung?• Warum sind Krebs und Thrombose so eng miteinander verbunden?• Welche physiologische Aufgabe hat der Tissue Factor im gesunden Körper?• Wie missbrauchen Tumoren Gerinnungsfaktoren für ihr Wachstum?• Welche doppelte Rolle spielen Blutplättchen bei Immunabwehr und Entzündung?• Warum ist Sepsis eine besonders gefährliche thromboinflammatorische Erkrankung?• Was hat Covid-19 über die Verbindung von Virusinfektion, Gerinnung und Entzündung gezeigt?• Wie verändert der Alterungsprozess die Blutbildung im Knochenmark?Weitere Informationen zu Prof. Wolfram Ruf findest du hier: https://www.unimedizin-mainz.de/cth/professuren-arbeitsgruppen-gastwissenschaftler/ruf-wissenschaftlicher-direktor.htmlDu interessierst dich für Gesunde Langlebigkeit (Longevity) und möchtest ein Leben lang gesund und fit bleiben, dann folge mir auch auf den sozialen Kanälen bei Instagram, TikTok, Facebook oder YouTube.https://www.instagram.com/nina.ruge.officialhttps://www.tiktok.com/@nina.ruge.officialhttps://www.facebook.com/NinaRugeOffiziellhttps://www.youtube.com/channel/UCOe2d1hLARB60z2hg039l9g Disclaimer: Ich bin keine Ärztin und meine Inhalte ersetzen keine medizinische Beratung. Bei gesundheitlichen Fragen wende dich bitte an deinen Arzt/deine Ärztin.STY-255

Send us a textDie Wahl des Hypnotikums zur Notfallintubation kritisch kranker Patient:innen ist seit Jahren Gegenstand intensiver Diskussionen. In dieser Episode analysieren wir die RSI-Studie aus dem New England Journal of Medicine, die Ketamin und Etomidat hinsichtlich Mortalität und kardiovaskulärer Komplikationen während der Intubation systematisch vergleicht.Casey JD, Seitz KP, Driver BE, et al.; for the RSI Investigators and the Pragmatic Critical Care Research Group.Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults.New England Journal of Medicine. Published online December 9, 2025.DOI: 10.1056/NEJMoa2511420Die tracheale Intubation kritisch kranker Patient:innen ist mit einer hohen Morbidität und Mortalität assoziiert. Während Etomidat aufgrund seiner hämodynamischen Stabilität eingesetzt wird, bestehen seit Langem Bedenken hinsichtlich einer durch Etomidat induzierten Suppression der Nebennierenfunktion und möglicher negativer Effekte auf das Überleben. Ketamin gilt als Alternative, da es die Kortisolproduktion nicht hemmt, jedoch ebenfalls potenziell hämodynamische Nebenwirkungen aufweist.In einer pragmatischen, multizentrischen, randomisierten Studie wurden 2365 kritisch kranke Erwachsene in 14 Notaufnahmen und Intensivstationen in den USA entweder Ketamin oder Etomidat zur Narkoseeinleitung bei der endotrachealen Intubation zugeteilt. Der primäre Endpunkt war die Gesamtmortalität im Krankenhaus bis Tag 28. Als sekundärer Endpunkt wurde ein kardiovaskulärer Kollaps während der Intubation definiert, bestehend aus schwerer Hypotonie, neuem oder eskaliertem Vasopressorbedarf oder Herzstillstand.Die 28-Tage-Mortalität unterschied sich nicht signifikant zwischen den Gruppen (28,1 % unter Ketamin vs. 29,1 % unter Etomidat). Dieses Ergebnis war konsistent über alle präspezifizierten Subgruppen hinweg, einschließlich Patient:innen mit Sepsis oder septischem Schock, hoher Krankheitslast (APACHE-II-Score ≥ 20) sowie präinterventioneller Vasopressortherapie. Im Gegensatz dazu trat ein kardiovaskulärer Kollaps während der Intubation unter Ketamin signifikant häufiger auf als unter Etomidat, insbesondere bei Patient:innen mit Sepsis oder hoher Erkrankungsschwere.Die Ergebnisse der RSI-Studie zeigen, dass Ketamin im Vergleich zu Etomidat keine Reduktion der kurzzeitigen Mortalität bewirkt, jedoch mit einem erhöhten Risiko hämodynamischer Instabilität während der Intubation einhergeht. Damit liefern die Daten eine wichtige evidenzbasierte Grundlage für die individualisierte Auswahl des Induktionshypnotikums bei kritisch kranken Patient:innen.Weiterführende Literatur:1. Ketamine Versus Etomidate for Rapid Sequence Intubation: A Systematic Review and Meta-Analysis of Randomized Trials. Critical Care Medicine. 2025. Greer A, Hewitt M, Khazaneh PT, et al.2. Readdressing Rapid Sequence Induction and Intubation Using Ketamine or Etomidate: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Medicine. 2025. de Morais LB, Radel-Neto GR, Dos Santos Valsecchi VA, Costa RA, Hueb W.3. Ketamine Versus Etomidate as an Induction Agent for Tracheal Intubation in Critically Ill Adults: A Bayesian Meta-Analysis.Critical Care. 2024. Koroki T, Kotani Y, Yaguchi T, et al.4. Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient. Critical Care Medicine. 2023. Acquisto NM, Mosier JM, Bittner EA, et al.

Eric Chase sits down with Jimmy Apple, aka EMS Avenger, to explore the often-overlooked realities behind emergency medical services. Jimmy breaks down the isolation many providers face, emphasizing the power of genuine relationships and networking in advancing EMS careers. They dive deep into the psychological challenges of frontline care, including the emotional toll of death notifications and the importance of accessible mental health support. With a spotlight on evidence-based practice, Jimmy contrasts the intense focus on cardiac arrest resuscitation with the relative neglect of sepsis recognition and treatment, urging a shift in EMS training priorities. Drawing from two decades of experience, he challenges outdated dogma around pediatric and adult care, encouraging providers to overcome fear and trust their skills. This conversation serves as a powerful reminder that EMS isn't just about protocols—it's about empathy, accountability, and continuous growth in service of human life.

Los artículos que se tratan en el episodio de hoy están listados aquí: The neonatal SOFA score in very preterm neonates with early-onset sepsis. Tagerman M, Sahni R, Polin R. Pediatr Res. 2025 Oct 9. doi: 10.1038/s41390-025-04068-z. Online ahead of print.PMID: 41068313Systemic Postnatal Corticosteroids, Bronchopulmonary Dysplasia, and Survival Free of Cerebral Palsy. Doyle LW, Mainzer R, Cheong JLY. JAMA Pediatr. 2025 Jan 1;179(1):65-72.doi: 10.1001/jamapediatrics.2024.4575.PMID: 39556404 Bienvenidos a La Incubadora: una conversación sobre neonatología y medicina basada en evidencia. Nuestros episodios ofrecen la dosis ideal (en mg/kg) de los más recientes avances para el neonato y para las increíbles personas que forman parte de la medicina neonatal.Soy tu host, Maria Flores Cordova, MD.Este podcast está presentado por los médicos neonatólogos Dani de Luis Rosell, Elena Itriago, Carolina Michel y Juliana Castellanos.No dudes en enviarnos preguntas, comentarios o sugerencias a nuestro correo electrónico: nicupodcast@gmail.comSíguenos en nuestras redes:Twitter: @incubadorapodInstagram: @laincubadorapodcastCreado originalmente por Ben Courchia MD y Daphna Yasova Barbeau MD http://www.the-incubator.org  Bienvenidos a La Incubadora: una conversación sobre neonatología y medicina basada en evidencia. Nuestros episodios ofrecen la dosis ideal (en mg/kg) de los más recientes avances para el neonato y para las increíbles personas que forman parte de la medicina neonatal. Soy tu host, Maria Flores Cordova, MD. Este podcast está presentado por los médicos neonatólogos Dani de Luis Rosell, Elena Itriago, Carolina Michel y Juliana Castellanos. No dudes en enviarnos preguntas, comentarios o sugerencias a nuestro correo electrónico: nicupodcast@gmail.comSíguenos en nuestras redes:Twitter: @incubadorapodInstagram: @laincubadorapodcast Creado originalmente por Ben Courchia MD y Daphna Yasova Barbeau MD http://www.the-incubator.org

Ingreso de aviones militares de EU solo será bajo condiciones especiales Aseguran tráiler con electrónicos de contrabandoIA ayuda a identificar riesgo de sepsis tras cirugíasMás información en nuestro podcast 

En ung mann dør av sepsis i akuttmottak i denne casen fra en ekte tilsynssak. Våre fagansvarlige leger gir deg tre enkle grep som kan hindre at dette skjer på din vakt. Du får et praktisk rammeverk for å oppdage alvorlig sykdom tidlig, med NEWS og vår beryktede "hageslange" som gjør de vitale målingene mye mer forståelige i praksis. Til slutt får du også en enkel startpakke til sykdomslære, med observasjonskompetanse, sepsis og sjokk som en liten troika som gir deg flyt i oppstarten på et stort og krevende fagfelt.Anbefalte videoer:1) Klinisk observasjon2) Sepsis3) Sjokk

Sepsis affects millions of people each year and remains one of the most complex and deadly medical emergencies facing healthcare today. Michelle Lewis, Senior Director of PI Programs at Vizient, is joined by Shannon Hale, Senior PI Programs Director and sepsis subject matter expert, to explore why sepsis is so difficult to identify. Together, they discuss awareness gaps that still exist across providers, staff and communities.  Guest Speaker:  Shannon Hale, MHA, RN, CPHQ Senior Program Director Performance Improvement Programs   Host:  Michelle Lewis Senior Director Programs Performance Improvement Programs   Show Notes:  [00:47] Why sepsis remains a critical and complex challenge in healthcare [01:58] Vizient sepsis projects and what members are struggling with most [2:45] Lessons learned from sepsis performance improvement teams and the role of champions [03:43] Executive sponsorships and celebrating wins  [06:10] Sustaining education, addressing staff and resident turnover [07:10] New approaches to education including social media and community engagement [08:28] How organizations and individuals can increase sepsis awareness  [10:09] Public policy advocacy and educating lawmakers about sepsis  [11:01] Potential role of AI in earlier identification    Links | Resources: Contacting Knowledge on the Go: picollaboratives@vizientinc.com   Subscribe Today! Apple Podcasts Spotify YouTube Android RSS Feed

The science is finally catching up to what clinicians have long known: more fluids aren't always the answer to septic shock. In this episode, host Sarah Lorenzini and Jaclyn Bond MSN-LM, MBA-HM explain what the ANDROMEDA-SHOCK 2 trial reveals about physiology-guided sepsis resuscitation and why fixed-volume fluid strategies can lead to avoidable harm.They break down how dynamic fluid responsiveness testing helps teams stop guessing, and how tools like FloPatch support real-time assessment of carotid flow time and stroke volume. You'll leave with a clearer idea of when to give fluids, when to stop, and how to justify the decision.Topics discussed in this episode:The purpose and key findings of the ANDROMEDA-SHOCK 2 studyWhy dynamic measures of fluid responsiveness matter more than static vitalsWhat recent meta-analysis data shows about physiology-guided fluid strategiesCarotid flow time: what it is, how it's measured, and how it guides decisionsHemodynamic assessment and bedside limitationsHow FloPatch supports real-time assessment so you can make individualized fluid decisionsSEP-1 2026 guideline updates and why it's better for patientsHow to apply these principles to your workflow Website: www.flosonicsmedical.com See FloPatch in action: https://hubs.ly/Q03-68Hg0Mentioned in this episode:CONNECT

Send us a textIn this episode of The Incubator Podcast, Ben and Daphna review a pivotal population-based study from Norway examining a new approach to Early-Onset Sepsis (EOS). The hosts discuss whether serial physical examinations can safely replace routine antibiotic prophylaxis in at-risk term and late-preterm infants. With antibiotic exposure often far exceeding sepsis incidence, this study offers compelling data for a "less is more" strategy. Tune in as Ben and Daphna explore the safety, efficacy, and bedside implications of substituting automatic treatment with structured clinical monitoring—and what this means for reducing unnecessary interventions in the NICU.----Serial physical examination to reduce unnecessary antibiotic exposure in newborn infants: a population-based study. Vatne A, Eriksen BHH, Bergqvist F, Fagerli I, Guthe HJT, Iversen KV, Ud Din FS, van der Weijde J, Kvaløy JT, Rettedal S.Arch Dis Child Fetal Neonatal Ed. 2025 Nov 19:fetalneonatal-2025-329639. doi: 10.1136/archdischild-2025-329639. Online ahead of print.PMID: 41260908Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

In this (rather delayed!) October round-up, Iain Beardsell and Simon Carley catch up on recent St Emlyn's blog posts and papers that continue to shape emergency and resuscitation practice. The discussion moves across trauma, analgesia, cardiac arrest physiology, emergency department systems, and antimicrobial stewardship—less about novelty, more about what actually holds up on shift. Trauma and haemorrhage The episode opens with a discussion of the FIRST-2 trial, examining fibrinogen concentrate and prothrombin complex concentrate versus fresh frozen plasma in severe traumatic haemorrhage. Despite promising physiological theory, the trial shows no meaningful reduction in blood product use compared with standard care, reinforcing the ongoing role of FFP in early trauma resuscitation. Upper limb injuries and regional anaesthesia The team explore the SUPERB trial comparing supraclavicular brachial plexus blocks with Bier's blocks for upper limb reductions. Both techniques provide excellent analgesia. The conversation reflects on changing practice, procedural sedation pressures, ultrasound access, and how physical space—not evidence—often dictates what we do. Cardiac arrest: signals worth paying attention to Three recent cardiac arrest papers are reviewed, focusing on physiological markers rather than new devices: End-tidal CO₂ as a CPR quality target Ventilation strategies during arrest, including chest-compression-synchronised ventilation Cerebral oximetry as a potential prognostic signal These are not definitive answers, but they point towards cardiac arrest management that is more physiological and less ritualistic. Emergency department systems: repair, not reinvention A reflective discussion on “designer repair” challenges the idea that emergency departments need constant transformation. Instead, the focus shifts to recognising and supporting the clinicians quietly holding fragile systems together every day—and why fixing small, broken things often matters more than grand redesigns. Sepsis and antibiotics The episode closes with a critical look at broad-spectrum antibiotic use in suspected sepsis. Observational data suggest significant overtreatment and real harm, reinforcing the need to pause, think, and choose the right antibiotic—not just the fastest one. This episode is a reminder that good emergency medicine is rarely about silver bullets. It's about judgement, physiology, and paying attention to what actually works in the real world. About MedPod Learn MedPod Learn is a medical podcast player designed to help turn listening into structured learning, with tools to support reflection, CPD, and appraisal. Available on the App Store and Google Play.

Chris digs deep on a patient assessment and also on the structural integrity of the building he's in. Will he do a commendable job, or will his plans... fall through?

Date: November 27, 2025  Guest Skeptic: Dr. Justin Morgenstern is an emergency physician and the creator of the #FOAMed project called www.First10EM.com Case: You are looking after a 65-year-old man who appears to be in septic shock. He presented after five days of fever and cough, and is now severely lethargic and hypotensive on arrival. You […] The post SGEM#498: Andromeda – Cap Refill Time for Personalized Sepsis Treatment first appeared on The Skeptics Guide to Emergency Medicine.

For The Other Side NDE Videos Visit ️ youtube.com/@TheOtherSideNDEYT Purchase our book on Amazon The Other Side: Stories From the Afterlife https://a.co/d/23Bbbsa  El's condition deteriorates quickly, with doctors warning her family that the chances of survival are nearly gone. Yet as her body fails, her awareness feels active—moving through unfamiliar spaces with the help of three distinct guides. She's shown how different outcomes branch from the same moment, and why certain bonds anchor someone to life. She returns with a deeper understanding of love, consciousness, and what truly matters beyond the physical world. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This week, Aebhric O'Kelly and Bill Vasios host an online discussion on the JTS sepsis CPG. CoROM students and members of the college join this live discussion about how to assess and treat the septic casualty in remote and austere environments. Chapters00:00 Introduction to C-Circulation Problems01:34 Understanding Sepsis and Its Management09:17 Early Warning Systems for Sepsis14:15 Clinical Acumen in Remote Care20:20 Monitoring and Assessing Patient Status27:52 Antibiotic Administration in Remote Settings33:02 Malaria Treatment Protocols37:33 Resuscitation Strategies for Sepsis42:52 Point of Care Ultrasound in Patient Monitoring48:12 Final Thoughts and Future TopicsYou can download the JTS CPG on Sepsis here. https://jts.health.mil/assets/docs/cpgs/Sepsis_Management_PFC_28_Oct_2020_ID83.pdf

Today, we're diving into a heartfelt conversation that every parent, advocate, and entrepreneur should definitely tune into. We've got Reasa Selph with us, a fierce advocate for patient safety and an award-winning business strategist, sharing her personal journey after her son Nicholas faced a life-threatening battle with sepsis. Just days after being sent home from the ER without proper treatment, Nicholas collapsed and spent over a month in intensive care, a harrowing experience that left him with permanent injuries. Reasa's story isn't just about survival; it's a call to action for parents everywhere to trust their instincts and advocate fiercely when the healthcare system falls short. So, grab your favorite snack, get comfy, and let's unpack this powerful tale of resilience, advocacy, and the urgent need for change in our medical systems.A heartfelt journey unfolds as we hear from Reasa Selph, a passionate advocate for patient safety and a business strategist who found herself battling not only for her son's life but for systemic changes in healthcare. When 11-year-old Nicholas was sent home from the ER despite showing alarming signs of sepsis, Reza's instincts screamed that something was wrong. Just two days later, Nicholas collapsed into septic shock, leading to a grueling month in intensive care filled with surgeries and uncertainty. This episode dives deep into the moments of fear, helplessness, and eventual empowerment that Reza experienced as she navigated the healthcare system that failed her family. Reasa shares crucial warning signs every parent should recognize and emphasizes the importance of trusting one's gut feelings, especially when it comes to advocating for a child's health. Her story is a stark reminder of the vulnerabilities inherent in medical systems and the resilience required to push for change. But it's not just about the struggle; Reasa's journey is also one of hope and determination. As she continues to run her marketing agency, she exemplifies how personal challenges can fuel professional growth. It's this duality of personal tragedy and professional ambition that creates a powerful narrative of resilience, encouraging listeners to become advocates not just for their own families but for all families navigating similar challenges. Tune in for a candid discussion that reminds us of the importance of vigilance, advocacy, and the strength found in community support as we all fight our own battles against the healthcare system.Takeaways: In this episode, we explore the heartbreaking journey of Reasa Selph and her son Nicholas, who faced a life-threatening battle with sepsis after being sent home from the ER. Reasa emphasizes the importance of trusting your instincts as a parent, especially when it comes to your child's health and advocating for necessary medical attention. We learned that sepsis can escalate rapidly, so recognizing warning signs like low blood pressure and confusion can be crucial for timely intervention. Reasa's experience sheds light on the systemic issues within healthcare, highlighting the need for accountability and mandatory protocols to prevent similar tragedies from happening to other families. Mentioned in this episode:Free Revenue Ceiling AuditDr. Noah's 30 years of experience to help you reach your next level. But hurry, because there are only 50 available this month. So if you're tired of being stuck at the same revenue level and want to finally break through, get your FREE Revenue Ceiling Audit. https://www.noahvault.com?aff=d28bf6c78150c7f09896297dfe1701c1cd191ac6fc9976779212cec5d38e94d6

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Marilyn N. Bulloch, PharmD, BCPS, FCCM, speaks with Olfa Hamzaoui, MD, PhD, professor of intensive care at Robert Debré Hospital in Reims, France, about her Peter Safar Honorary Lecture at the 2025 Critical Care Congress. The conversation centers on tissue perfusion, microcirculation, and shock, with a focus on bridging the gap between bench research and bedside practice. Dr. Hamzaoui shares insights on current scientific understanding of microcirculation and shock, including research on tools to monitor microcirculation, such as handheld video microscopy. The discussion highlights the utility of capillary refill time as a simple, noninvasive tool for guiding resuscitation. Dr. Hamzaoui advocates for early and repeated echocardiographic assessment in shock management, including during de-resuscitation. She also discusses her 2023 article in Clinical Medicine, which proposed titrating norepinephrine to individualized targets. This episode offers a compelling look at how emerging tools and research can refine shock management and promote precision care in critical illness. This podcast is sponsored by Fresenius Kabi. Resources referenced in this episode:  Effects of a Resuscitation Strategy Targeting Peripheral Perfusion Status versus Serum Lactate Levels Among Patients with Septic Shock. A Bayesian Reanalysis of the ANDROMEDA-SHOCK Trial (Zampieri FG, et al. Am J Respir Crit Care Med. 2020;201:423-429) The Eight Unanswered and Answered Questions about the Use of Vasopressors in Septic Shock (Hamzaoui O, et al. J Clin Med. 2023;12:4589) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 (Evans L, et al. Crit Care Med. 2021;49:e1063-e1143)

This week, Bobbi Conner talks with MUSC's Dr. Andy Goodwin about diagnosing and treating sepsis.

In this powerful episode of The Gritty Nurse Podcast, host Amie Archibald-Varley sits down with researcher Fatima Sheikh, a PhD candidate at McMaster University, to unpack the urgent crisis of sepsis. This conversation goes beyond the bedside, focusing on the social and structural determinants of health that fuel sepsis prevalence and worsen patient outcomes. Fatima argues for recognizing sepsis as a critical public health issue that begins in the community, not the hospital. Key topics discussed: The need for a national action plan to address policy gaps in sepsis care and prevention. The critical significance of equity in research and clinical practice. The role of community engagement in early recognition and prevention. The potential—and pitfalls—of using AI in sepsis diagnosis and management. This is a crucial listen for nurses, public health professionals, policymakers, and anyone concerned with health justice. Learn why treating sepsis as a medical emergency is essential and what structural changes are needed to save lives. More about Fatima: Fatima Sheikh (She/Her) is a PhD Candidate at McMaster University and a Health Equity Specialist at Hamilton Health Sciences. Her research focuses onunderstanding how social determinants of health influence both the incidence and outcomes of critical illnesses. She also explores how these determinants shape healthcare delivery, with the goal of informing equitable health policies, responsible evidence use, and inclusive care practices. Fatima's academic foundation includes a master's thesis centered on equity, diversity, and inclusion, in which she investigated how gender and ethnicity affect N95 respirator fit among a diverse group of Canadian healthcare workers. At the core of Fatima's work is a commitment to understanding how social and structural factors shape health and disease, their systemic implications, and the power of cross-sector collaboration to drive meaningful change. Listen now to learn why talking about death is the key to a better life. Where to Listen / Watch to THE GRITTY NURSE * Listen on Apple Podcasts – : The Gritty Nurse Podcast on Apple Apple Podcasts  https://podcasts.apple.com/ca/podcast/the-gritty-nurse/id1493290782 * Watch on YouTube –  https://www.youtube.com/@thegrittynursepodcast Stay Connected: Website: grittynurse.com Instagram: @grittynursepod TikTok: @thegrittynursepodcast X (Twitter): @GrittyNurse Collaborations & Inquiries: For sponsorship opportunities or to book Amie for speaking engagements, visit: grittynurse.com/contact Thank you to Hospital News for being a collaborative partner with the Gritty Nurse! www.hospitalnews.com   

In this episode, our host Dr. Suzanne Dixon, talks to Dr. Bhaskari Burra, a MAHEC OB/GYN Fellow, about Sepsis. Sepsis is a leading cause of maternal morbidity and mortality, and in this episode our speakers will discuss how to recognize it, how to respond, the sources of infection and long-term effects.  They will also share some resources to help maintain best practices when working with patients with sepsis, and helping them to navigate their recovery.ResourcesSMFM Consult Series #47: Sepsis during pregnancy and the puerperiumCalifornia Maternal Quality Care Collaborative Sepsis ToolkitWe would love your feedback on our podcast!  Please take our listener survey to provide your comments.Follow us on FacebookFollow us on InstagramMusic credit: "Carefree" Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 4.0 Licensehttp://creativecommons.org/licenses/by/4.0/Please provide feedback here:https://redcap.mahec.net/redcap/surveys/?s=XTM8T3RPNK

Sepsis is a life-threatening overreaction of your immune system to infection, causing widespread inflammation and organ failure when not treated quickly A large Australian study found people with Type 2 diabetes were twice as likely to develop sepsis, with the highest risk seen in men, smokers, and younger adults aged 41 to 50 Chronic high blood sugar and insulin resistance weaken immune defenses, impairing white blood cell function, slowing wound healing, and allowing common infections like urinary or skin infections to escalate into sepsis Managing diabetes through blood sugar control, physical activity, sunlight exposure, and eliminating vegetable oils and refined sugar restores insulin sensitivity and lowers the likelihood of severe infection You can further reduce infection and sepsis risk by maintaining wound hygiene, treating infections promptly, eating nutrient-rich foods, managing chronic conditions, and avoiding habits like nail-biting

Your pneumonia patient is hypotensive, tachycardic, and not responding to fluids… what did you miss? It could be sepsis-induced cardiomyopathy, a common under-recognized shock state you could see at the bedside.In this episode, Dr. Mahmoud Ibrahim MD and host Sarah Lorenzini use a case study to highlight how nurses, intensivists and the ICU team can work together to recognize the signs of sepsis-induced cardiomyopathy early and give patients a better chance at recovery. You'll learn the diagnostic clues that your patient's heart is in trouble, how to approach controversial treatments like sodium bicarb, and what has to happen before intubation in a dual shock state.Topics discussed in this episode:What the initial bedside assessment says about the patientTreatment priorities for the  intensivist and nurseSigns that point to more than just sepsisWhy fluids aren't always the answerBlood pressure management: vasopressors and inotropesPathophysiology of sepsis-induced cardiomyopathyHow a sepsis-induced cardiomyopathy diagnosis changes treatmentThe vasopressin debate for sepsis-induced cardiomyopathyClues your intervention isn't working and what to do nextHow to prepare the patient for high-risk intubationWhat you need to know about administering sodium bicarbWhy collaboration matters at every step for patient recoveryConnect with Dr. Ibrahim:Instagram: https://www.instagram.com/icuboy_meded/Facebook: https://www.facebook.com/share/1Dg1ZTyfsN/TikTok: https://www.tiktok.com/@icuboy_mededThreads: https://www.threads.com/@icuboy_mededX: https://x.com/icuboy_mededLearn more about the different phenotypes in sepsis induced cardiomyopathy:https://journal.chestnet.org/article/S0012-3692(25)05143-8/abstractMentioned in this episode:CONNECT

A USA TODAY exclusive investigation found thousands of in-custody deaths that could have been easily prevented. USA TODAY Investigative Data Reporter Austin Fast explains what the records reveal about sepsis, medical neglect and the human cost for families left behind. He shares stories from jails and prisons across the country, including people who died waiting for basic care and inmates who feared punishment for asking for help.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Endotoxin, a toxic molecule released by bacteria in your gut, enters your bloodstream and directly triggers blood clot formation — even in people with no signs of infection or heart disease Researchers have shown that certain bacterial types, such as E. coli, are especially effective at setting off your body's clotting response, mimicking what happens during sepsis and other life-threatening events Everyday habits that weaken your gut barrier — including eating seed oils, ultraprocessed foods, and alcohol, or living under chronic stress — make endotoxin exposure common, keeping your blood in a "primed" state to clot Chronic, low-grade exposure to bacterial toxins links gut health to cardiovascular problems, explaining why heart attacks, strokes, and clotting disorders often strike people who appear healthy Supporting your gut with easy-to-digest foods, antioxidants like niacinamide and vitamin E, and natural binders such as raw carrot salad or activated charcoal helps neutralize endotoxin and keep your blood flowing freely

Sepsis and bloodstream infections (BSIs) are common and cause millions of deaths each year, with a disproportionate burden in low-income and middle-income countries. Tune in to learn from Jasmine R. Marcelin, MD, FACP, FIDSA, how inadequate antibiotic coverage can be linked to increased mortality and length of stay and how unnecessary broad-spectrum antibiotics can drive antimicrobial resistance. Topics covered include:The worldwide burden of sepsis and BSIsThe ongoing threat of antimicrobial resistanceUS and global health disparities in sepsis, BSI, and antimicrobial resistanceBarriers toward optimizing antibiotic use in BSIsPresenter:Jasmine R. Marcelin, MD, FACP, FIDSAAssociate Professor, Infectious DiseaseAssociate Medical Director, Antimicrobial Stewardship ProgramVice Chair for Belonging and Community Engagement, Department of Internal MedicineCo-Director, Digital Innovation & Social Media Strategy, Division of Infectious DiseasesUniversity of Nebraska Medical CenterOmaha, NebraskaLink to full program and downloadable slides:https://bit.ly/4inoXCxGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Unnecessary broad-spectrum antibiotics can drive antimicrobial resistance and cause adverse events, whereas inadequate antibiotic coverage is linked to increased mortality and length of stay for patients with bloodstream infections (BSIs). Listen now to learn from Jose Alexander, MD, D(ABMM), CIC, FCCM, SM/MB(ASCP), how to use rapid genotypic and phenotypic antimicrobial susceptibility testing results to inform antibiotic selection for patients with gram-negative BSIs. Topics covered include:Typical patterns of intrinsic antibiotic susceptibility and resistance in EnterobacteralesMechanisms of resistance in gram-negative bacteriaGenotypic rapid diagnostic tests for BSIsResistance markers for earlier targeted therapyRapid phenotypic antimicrobial susceptibility test platforms for blood culturesPresenter:Jose Alexander, MD, D(ABMM), CIC, FCCM, SM/MB(ASCP)Medical and Public Health MicrobiologistMedical and Technical Director of MicrobiologyAdventHealthOrlando, FloridaLink to full program and downloadable slides:https://bit.ly/4inoXCxGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Rapid phenotypic antimicrobial susceptibility testing (AST) significantly reduces time to actionable results and can improve antibiotic decision-making for patients with bloodstream infections. Listen in to learn from Michael P. Veve, PharmD, MPH, how to optimally integrate rapid phenotypic AST into clinical practice, including incorporation into your existing antimicrobial stewardship workflow. Topics covered include:Considerations for implementationDecision-making steps for implementationThe role of antimicrobial stewardship programs in AST workflowPresenter:Michael P. Veve, PharmD, MPHClinical Associate ProfessorDepartment of Pharmacy PracticeEugene Applebaum College of Pharmacy and Health SciencesWayne State UniversityClinical Pharmacy Specialist, Infectious DiseaseHenry Ford HospitalDetroit, MichiganLink to full program and downloadable slides:https://bit.ly/4inoXCxGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

A new version of the Sequential Organ Failure Assessment (SOFA) score, has been introduced.The new revision aligns the organ dysfunction measurement in critically ill adults with current clinical practices, especially those diagnosed with sepsis.Published Oct. 29 in Journal of the American Medical Association (JAMA) and is available here https://jamanetwork.com/journals/jama/fullarticle/2840822.During the next live edition of Talk Ten Tuesday, Dr. James S. Kennedy will discuss this new SOFA-2 revision and its expected impact on clinical validation for sepsis – defined by Sepsis-3 as a life-threatening organ dysfunction caused by a dysregulated host response to infection – and how facility clinical workflows can negotiate denial avoidance with payers with this challenging diagnosis.The broadcast will also feature these instantly recognizable panelists, who will report more news during their segments:CDI Report: Cheryl Ericson, Senior Director of Clinical Policy and Education for the vaunted Brundage Group, will have the latest CDI updates.The Coding Report: Christine Geiger, Assistant Vice President of Acute and Post-Acute Coding Services for First Class Solutions, will report on the latest coding news.MyTalk: Angela Comfort, veteran healthcare subject-matter expert, will co-host the broadcast. Comfort is the Assistant Vice President of Revenue Integrity for Montefiore Health.

The JournalFeed podcast for the week of Oct 27-31, 2025.These are summaries from just 2 of the 5 articles we cover every week! For access to more, please visit JournalFeed.org for details about becoming a member.Monday's Spoon Feed:Early fluid resuscitation in sepsis shows a U-shaped relationship between fluid amount and mortality; 30 mL/kg within 3 hours improves survival, supporting current Surviving Sepsis Campaign guidance.Friday's Spoon Feed:Azelastine nasal spray used three times daily for 56 days significantly reduced PCR-confirmed SARS-CoV-2 infections versus placebo.

Joshua Geltman, MD, MBA, Physician Chair of the Sepsis Committee at Northern Westchester Hospital, discusses the seriousness of sepsis and its growing impact in inpatient care. He highlights current trends, the role of predictive analytics in improving early detection, and how data-driven approaches can drive meaningful change in sepsis management and patient outcomes.