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There is so much to enjoy in "Shang-Chi and the Legend of the Ten Rings." Simu Liu and Awkwafina are great together and there's one really excellent fight. But, a perfect movie it is not and a lot of its problems are rooted in issues the MCU has been facing for years, from bland villains to overly CG climactic battles. This week, we discuss.
For Video Edition, Please Click and Subscribe Here: https://youtu.be/CQJzf028fVo www.calmfidencebook.com Learn how to communicate —inside and out—with calm, confidence, no matter the circumstances, with a collection of tips, tools, natural remedies, client stories, and on-the-spot exercises from PATRICIA STARK, Communication Expert, and Personal and Professional Development Trainer. CALMFIDENCE: How to Trust Yourself, Tame Your Inner Critic, and Shine in Any Spotlight By Patricia Stark Just Released! ABOUT THE AUTHOR Patricia Stark is President of Patricia Stark Communications and Calmfidence® Workshops. Clients include, ESPN, NASA TV, Glamour, Amazon, BET, Turner Broadcasting, CBS, OWN, NASCAR, Conde Nast, Spotify, Quaker Oats, Discovery Channel, E! News, NASCAR, and the Miss American Organization. Patricia works with closely with celebrities, corporate executives, authors, news anchors, social media influencers, and others whose careers rely on their ability to communicate confidently. Patricia has extensive experience as a Health and Wellness Anchor and Television Host, National & International News Anchor and has served as a contributor for the History Channel and the Huffington Post as well as a guest television expert. Patricia is a guest lecturer at colleges and universities including Fordham University and LIU on the topics of Communication Skills, Calmfidence®, Public Speaking Skills, Interpersonal Skills Interview Skills and Stress and Anxiety Busters. She lives in New York. For more, see PatriciaStark.com and Calmfidencebook.com Praise for CALMFIDENCE “A unique take on self-help that everyone should read.
Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers suicide epidemiology, and prevention with Dr. Juveria Zaheer, a Clinician Scientist with the Institute for Mental Health Policy Research, and Education Administrator in the Gerald Sheff and Shanitha Kachan Emergency Department at CAMH in Toronto, Ontario. She is also an Assistant Professor in the Department of Psychiatry at the University of Toronto. She utilizes both quantitative and qualitative methods to better understand suicide and identify areas of potential improvement. The learning objectives for this episode are as follows: By the end of this episode, you should be able to… Develop an awareness of suicide risk and prevalence, as it pertains to the general population and psychiatric populations Incorporate additional contextual information into suicide risk assessment that goes beyond SADPERSONS and other list-based approaches Develop a deeper understanding of how to approach and help individuals with suicidal thoughts and behaviours Guest expert: Dr. Juveria Zaheer Hosts: Dr. Chase Thompson (PGY4) Episode production: Dr. Weam Sieffien, Dr. Vincent Tang, and Dr. Chase Thompson Audio editing: Dr. Chase Thompson Show notes: Dr. Chase Thompson 00:00 – Introduction 01:14 – Learning objectives 04:00 – Overview of suicide rates across populations 07:20 - Sex and gender differences in suicide 08:50 - Suicide following discharge from hospital 14:10 - Finding suitable dispositions for individuals dealing with suicidal thoughts and behaviors 20:50 - Meeting patients and families where they are at 23:30 - Suicide safety plans 28:30 - Evidence-based approaches to suicide prevention 32:30 - Commentary on strength of evidence for interventions in suicide prevention 38:40 - Addressing suicidality in borderline personality disorder 47:00 - Ethics of involuntary hospitalization for suicidality 50:00 - Future of suicide prevention References: Borecky, A., Thomsen, C., & Dubov, A. (2019). Reweighing the ethical tradeoffs in the involuntary hospitalization of suicidal patients. The American Journal of Bioethics, 19(10), 71-83. Cipriani, A., Hawton, K., Stockton, S., & Geddes, J. R. (2013). Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. Bmj, 346. Chung, D., Hadzi-Pavlovic, D., Wang, M., Swaraj, S., Olfson, M., & Large, M. (2019). Meta-analysis of suicide rates in the first week and the first month after psychiatric hospitalisation. BMJ open, 9(3), e023883. Chung, D. T., Ryan, C. J., Hadzi-Pavlovic, D., Singh, S. P., Stanton, C., & Large, M. M. (2017). Suicide rates after discharge from psychiatric facilities: a systematic review and meta-analysis. JAMA psychiatry, 74(7), 694-702. Guzmán, E. M., Cha, C. B., Ribeiro, J. D., & Franklin, J. C. (2019). Suicide risk around the world: a meta-analysis of longitudinal studies. Social psychiatry and psychiatric epidemiology, 54(12), 1459-1470. Kessler, R. C., Bossarte, R. M., Luedtke, A., Zaslavsky, A. M., & Zubizarreta, J. R. (2020). Suicide prediction models: a critical review of recent research with recommendations for the way forward. Molecular psychiatry, 25(1), 168-179. Mann, J. J., Apter, A., Bertolote, J., Beautrais, A., Currier, D., Haas, A., ... & Hendin, H. (2005). Suicide prevention strategies: a systematic review. Jama, 294(16), 2064-2074. Miller, I. W., Camargo, C. A., Arias, S. A., Sullivan, A. F., Allen, M. H., Goldstein, A. B., ... & Ed-Safe Investigators. (2017). Suicide prevention in an emergency department population: the ED-SAFE study. JAMA psychiatry, 74(6), 563-570. Sakinofsky, I. (2014). Preventing suicide among inpatients. The Canadian journal of psychiatry, 59(3), 131-140. Stanley, B., Brown, G. K., Brenner, L. A., Galfalvy, H. C., Currier, G. W., Knox, K. L., ... & Green, K. L. (2018). Comparison of the safety planning intervention with follow-up vs usual care of suicidal patients treated in the emergency department. JAMA psychiatry, 75(9), 894-900. Zaheer, J., Jacob, B., de Oliveira, C., Rudoler, D., Juda, A., & Kurdyak, P. (2018). Service utilization and suicide among people with schizophrenia spectrum disorders. Schizophrenia research, 202, 347-353. Zaheer, J., Links, P. S., & Liu, E. (2008). Assessment and emergency management of suicidality in personality disorders. Psychiatric Clinics of North America, 31(3), 527-543. CPA Note: The views expressed in this podcast do not necessarily reflect those of the Canadian Psychiatric Association (CPA). For more PsychEd, follow us on Twitter (@psychedpodcast), Facebook (PsychEd Podcast), and Instagram (@psyched.podcast). You can provide feedback by email at psychedpodcast@gmail.com. For more information, visit our website at psychedpodcast.org.
LIU Head Coach Derek Kellogg joins us to preview his team's upcoming game against UConn. We talk about his first three years on the job, break down his roster, talk about his relationship with Dan Hurley, and more.
Greg talks about why he does not do in-game bets, recaps Thursday's college basketball results, talks to Jim Root of the Three Man Weave his opening night takeaways and his thoughts on Thursday's games, & Greg picks & analyze EVERY Thursday college basketball game! Podcast Highlights 2:52-Why Greg doesn't do in game bets 3:57-Recap of Thursday's college basketball action 10:32-Picks & analysis for Northeastern vs Georgia St 12:44-E Washington vs UC Davis 14:45-N Dakota St vs Cal Poly 16:49-Utah St vs Richmond 19:03-Illinois St vs E Michigan 21:24-W Michigan vs Michigan St 23:36-E Tennessee St vs Appalachian St 25:55-Picks & analysis for Ket St vs Xavier 28:09-Picks & analysis for Wright St vs Marshall 30:39-Picks & analysis for Niagara vs Ohio St 32:44-Picks & analysis for UNC Greensboro vs N Kentucky 34:59-Picks & analysis for Marist vs Columbia 37:28-Picks & analysis for N Illinois vs Indiana 39:26-Picks & analysis for Canisus vs E Carolina 41:38-Picks & analysis for Furman vs Louisville 43:57-Picks & analysis for Fordham vs Manhattan 46:13-Picks & analysis for Wofford vs Clemson 48:28-Robert Morris vs Kentucky 50:23-Penn vs George Mason 52:14-Morehead St vs UAB 54:10-W Carolina vs Wake Forest 56:02-Picks & analysis for UMKC vs Iowa 57:49-Picks & analysis for E Illinois vs St. Louis 59:56-Picks & analysis for Abilene Christian vs Texas A&M 1:01:45-Picks & analysis for Louisiana vs So Miss 1:03:53-Picks & analysis for S Dakota St vs Alabama 1:06:02-Picks & analysis for UW Green Bay vs Wisconsin 1:07:46-Picks & analysis for LA Monroe vs Auburn 1:09:36-Tarleton St vs Kansas 1:11:41-Picks & analysis for Rice vs Houston 1:13:35-Picks & analysis for Oakland vs Oklahoma St 1:15:29-Picks & analysis for Oregon St vs Iowa St 1:17:32-Picks & analysis for UTSA vs Oklahoma 1:19:35-Picks & analysis for UMass vs Yale 1:21:21-Picks & analysis for Texas St vs LSU 1:23:12-Picks & analysis for SIU Edwardsville vs Chicago St 1:25:38-Picks & analysis for Austin Peay vs S Illinois 1:27:39-Picks & analysis for Indiana St vs Purdue 1:29:51-Picks & analysis for Pitt vs W Virginia 1:32:02-Picks & analysis for Sam Houston vs Nebraska 1:34:07-Picks & analysis for Arkansas St vs Illinois 1:35:57-Picks & analysis for So Illinois vs Dixie St 1:38:01-Picks & analysis for San Diego St vs BYU 1:39:48-Picks & analysis for Brown vs UNC 1:41:54-Picks & analysis for UT Rio GV vs Arizona 1:43:54-Picks & analysis for Idaho St vs Pepperdine 1:45:42-Picks & analysis for San Diego vs Nevada 1:47:56-Picks & analysis for Seattle vs Washington St 1:49:41-Picks & analysis for Stanford vs Santa Clara 1:51:45-Picks & analysis for SMU vs Oregon 1:54:13-NY Post Pick Villanova vs UCLA 1:56:19-Picks & analysis for W Kentucky vs Minnesota 1:58:34-Picks & analysis for Princeton vs S Carolina 2:02:58-Start of extra game picks with Hartford vs Campbell 2:04:49-Picks & analysis for S Carolina St vs Loyola MD 2:06:25-Picks & analysis for FDU vs Drexel 2:08:10-Picks & analysis for Bryant vs Rhode Island 2:09:56-Picks & analysis for C Arkansas vs Butler 2:11:29-Picks & analysis for USC Upstate vs Charlotte 2:13:14-Picks & analysis for American vs William & Mary 2:14:55-Picks & analysis for VMI vs Presbyterian 2:16:57-Picks & analysis for Radford vs Virginia 2:18:54-Picks & analysis for Army vs Duke 2:20:23-Picks & analysis for Coppin St vs Rider 2:22:27-Picks & analysis for Bethune Cookman vs Middle Tennessee 2:24:43-Charleston So vs Ole Miss 2:26:18-Holy Cross vs Boston College 2:28:15-Jackson St vs LA Tech 2:30:36-Lipscomb vs Charleston 2:32:34-Stetson vs GA Tech 2:34:14-Cornell vs Lafayette 2:36:00-High Point vs Northwestern 2:38:15-Grambling vs Texas Tech 2:40:05-New Hampshire vs Marquette 2:42:00-Incarnate Word vs Baylor 2:43:46-Virginia Tech vs Navy 2:45:39-N Florida vs Grand Canyon 2:47:40- Arkansas PB vs Colorado St 2:49:28-LIU vs Fresno St 2:51:22-Texas So vs St. Mary's Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Epigenetics Podcast, we caught up with Marieke Oudelaar from the Max Planck Institute for Biophysical Chemistry to talk about her work on chromatin organization during development and disease. Marieke Oudelaar and her team focus on on developing high-resolution Chromosome Conformation Capture (3C) based techniques, like low-input Capture-C, Tri-C, and Tiled-C. Those techniques are then used in combination with other genomic techniques, genetic perturbations, and computational approaches to investigate the 3D structure of chromatin in development and disease. The team focused on the interplay between genome organisation and regulation during mammalian differentiation, and how perturbations in these processes contribute to human disease, including cancer. References Oudelaar, A. M., Davies, J. O. J., Downes, D. J., Higgs, D. R., & Hughes, J. R. (2017). Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C. Nucleic Acids Research, 45(22), e184–e184. https://doi.org/10.1093/nar/gkx1194 Oudelaar, A. M., Davies, J. O. J., Hanssen, L. L. P., Telenius, J. M., Schwessinger, R., Liu, Y., Brown, J. M., Downes, D. J., Chiariello, A. M., Bianco, S., Nicodemi, M., Buckle, V. J., Dekker, J., Higgs, D. R., & Hughes, J. R. (2018). Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains. Nature Genetics, 50(12), 1744–1751. https://doi.org/10.1038/s41588-018-0253-2 Oudelaar, A. M., Beagrie, R. A., Gosden, M., de Ornellas, S., Georgiades, E., Kerry, J., Hidalgo, D., Carrelha, J., Shivalingam, A., El-Sagheer, A. H., Telenius, J. M., Brown, T., Buckle, V. J., Socolovsky, M., Higgs, D. R., & Hughes, J. R. (2020). Dynamics of the 4D genome during in vivo lineage specification and differentiation. Nature Communications, 11(1), 2722. https://doi.org/10.1038/s41467-020-16598-7 Aljahani, A., Hua, P., Karpinska, M. A., Quililan, K., Davies, J. O. J., & Oudelaar, A. M. (2021). Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF [Preprint]. Genomics. https://doi.org/10.1101/2021.08.10.455796 Related Episodes Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden) Unraveling Mechanisms of Chromosome Formation (Job Dekker) Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel) Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com
On this episode we talk with Rob Morgan who is the head coach with the Long Island University women's hockey program. We talk about his lengthy coaching career in Canada, China and the U.S., starting the LIU women's program from scratch and his advice on the current recruiting environment. You can learn more about the LIU Women's Hockey program here: https://www.liuathletics.com/sports/womens-ice-hockey Follow Rob and the LIU Women's hockey team on Twitter: @rdmorgsand @LIUWHockey on Instagram: @rdmorgs and @liuwhockey To learn more about minor hockey development and recruiting for both girls and boys, visit the Champs App website http://www.champs.app
Start of picks 3:31-UC San Diego vs Cal 5:35-S Illinois vs Little Rock 8:11-Akron vs Ohio St 10:29-St Peter's vs VCU 12:33-E Michigan vs Indiana 15:23-IUPUI vs Butler 17:41-Citadel vs Pit 20:07-App St vs Iona 22:49-UIC vs Dayton 25:05-FIU vs Georgia 27:27-Belmont.vs Ohio 30:02-Monmouth vs Charlotte 32:39-Kansas vs Michigan St 34:58-Toledo vs Valpo 37:21-Portland vs Arizona St 39:54-Oakland vs WVU 42:31-UT Martin vs Tennessee 45:24-Rider vs Duquesne 47:56-Evansville vs Cincinnati 50:09-Fairfield vs Providence 52:18-Siena vs St. Bonaventure 54:32-Quinnipiac vs Maryland 56:24-Delaware vs Davidson 58:42-Ball St vs GA Southern 1:01:10-Miami OH vs GA Tech 1:03:50-Bowling Green vs W Carolina 1:06:23-Canisius vs Miami 1:08:04-Niagara vs Xavier 1:10:26-Columbia vs Fordham 1:12:53-E Illinois vs Northwestern 1:14:56-Hofstra vs Houston 1:17:46-Elon vs Florida 1:19:55-UNC Wilmington vs IL St 1:22:39-TN Tech vs Memphis 1:24:18-C Michigan vs Missouri 1:26:53-UT Arlington vs OK St 1:29:10-Arkansas vs Mercer 1:31:33-Jacksonville St vs Wichita St 1:33:55-Auburn vs Morehead St 1:35:52-W Illinois vs Nebraska 1:37:45-UMKC v Minnesota 1:40:30-UW Milwakee vs N Dakota 1:43:00-UL Monroe v LSU 1:45:02-Ab Christian v Utah 1:47:13-Pepperdine v Rice 1:49:35-Indiana St v UW Green Bay 1:51:45-Dartmouth vs BC 1:53:58-SEMO v Missouri St 1:58:45-St. Thomas v Chi St 2:01:29-SIUE v Marquette 2:03:23-Utah Valley v Boise St 2:05:28-LA Tech v Bama 2:07:32-CSUN v USC 2:09:45-UC Irvine v NMST 2:12:09-Dixie St v Gonzaga 2:14:43-CS Fullerton v Santa Clara 2:16:57-Bradley v S Dakota St 2:19:18-UC Davis v Utah St 2:21:49-NY Post Pick Kentucky v Duke 2:24:08-Oral Roberts v Colorado St 2:26:14-Cleveland St v BYU 2:18:37-E Wash v Nevada 2:30:53-Tarleton St v Stanford 2:33:06-UC Riverside v SDSU 2:35:16-Montana St v Colorado 2:37:50-Portland St v Oregon St 2:39:41- No IL v Washington 2:42:19-Chattanooga v LMU 2:44:29-No AZ v Arizona 2:46:41-CS Bakersfield v UCLA 2:50:51-Alcorn St v Wash St 2:52:47-Mt St. Mary's v Nova 2:54:40-Bethune Cookman v USF 2:57:04-C Conn St v UConn 2:59:02-Lafayette v Syracuse 3:01:19-Boston U v Rhode Island 3:03:44-Towson v Albany 3:05:31-NC A&T v UNCG 3:08:02-USC Upstate v S Carolina 3:10:11-Loyola MD v UNC 3:12:11-Presbyterian v Clemson 3:13:47-SC St v E Carolina 3:15:51-Stony Brook v George Mason 3:18:00-Hartford v Wagner 3:20:29-TX So v Oregon 3:23:02-Northeastern v Colgate 3:25:13-NC Central v Richmond 3:27:15-UMBC v UMass 3:29:38-UNC Ash v UAB 3:32:02-New Orleans v Ole Miss 3:33:09-Cornell v Binghamton 3:36:09-Texas St v Incarnate Word 3:38:10-MS Valley v St. John's 3:40:24-TN St v Bama A&M 3:42:20-Bama St v WKU 3:44:26-Francis NY v Wisconsin 3:46:10-C Ark v St Louis 3:48:49-MD E Shore v St. Joe's 3:50:32-Nicholls v N Iowa 3:52:23-Coppin St v Loyola IL 3:54:20-Francis PA v G Washington 3:56:12-McNeese v SMU 3:58:35-Maine v VA Tech 4:01:35-Ark PB v Creighton 4:03:43-N Florida v TX Tech 4:05:35-Kennesaw St v IA St 4:07:41-NW St v Oklahoma 4:09:35-Bucknell v NC St 4:11:23-Sacred Heart v La Salle 4:13:32-Marist v American 4:15:37-SE LA v Tulane 4:17:51-Jackson St v Illinois 4:20:00-Houston Baptist v Texas 4:22:00-Navy v UVA 4:24:04-Bellarmine v Purdue 4:26:09-Southern v Louisville 4:28:14-Grambling v GCU 4:30:30-Longwood v Iowa 4:32:44-Prairie View v St. Mary's 4:34:45-LIU v San Fran Learn more about your ad choices. Visit megaphone.fm/adchoices
RYJ reviews Shang Chi and the Legend of the ten rings with Kelly Jones. Starring Simu Liu, Awkwafina, Meng'er Zhang, Fala Chen, Florian Munteanu, Benedict Wong, Michelle Yeoh, Ben Kingsley, and Tony Leung, Directed by Destin Daniel CrettonWritten by Dave Callaham, Destin Daniel Cretton, Andrew Lanham Follow me on IG, and Twitter - @ohitsbigronFollow Kelly Jones on Twitter - @khjones Show Art by Katie Helm, follow her on IG - @katieladybug3 Theme Music by Breakmaster Cylinder (Check out Time Well Spent, another podcast from ohitsBigRon studios)(Check out Solvable, another podcast hosted by Ronald Young Jr. from Pushkin Industries)4 of 5 starsAvailable in Theaters
Sobre la situación en el estrecho de Formosa hablamos con José María Liu, embajador de Taiwán en España. En la tertulia han intervenido: Ramón Tamames, catedrático de Estructura económica, y César Fernández, presidente de ISBIF, Instituto Superior de Bolsa Inversión y Finanzas
Entrevista con José María Liu, embajador de Taiwan en España.
durée : 00:59:08 - Schubert par le Quatuor Hermès, avec Omer Bouchez et Elise Liu - par : Aurélie Moreau - Le Quatuor Hermès a enregistré les quatuors « Rosamunde » et « La Jeune fille et la mort » de Franz Schubert (disque La Dolce Volta paru le 1/X/2021). Omer Bouchez et Elise Liu, 1er et 2d violons du Quatuor sont nos invités aujourd'hui.
This month on Episode 29 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the September 17th and October 1st issues of Circulation Research. This episode also features conversations with BCVS Outstanding Early Career Investigator Award finalists, Dr Jiangbin Wu from the University of Rochester, Dr Chen Gao from UCLA, and Dr Chris Toepfer from Oxford University. Article highlights: Raftrey, et al. Dach1 Extends Arteries and Is Cardioprotective Zhang, et al. Blood Inflammatory Exosomes and Stroke Outcome Joyce, et al. Cardiovascular Health and Epigenetic Age Liu, et al. Wls Suppresses Fibrosis in Heart Regeneration Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh. And today, I'll be highlighting articles presented in our September 17th and October 1st issues of Circulation Research. I also am going to speak with the BCVS Outstanding Early Career Investigator Award finalists, Dr Jiangbin Wu from the University of Rochester, Dr Chen Gao from UCLA, and Dr Chris Toepfer from Oxford University. Cindy St. Hilaire: The first article I want to share is titled, Dach1 Extends Artery Networks and Protects Against Cardiac Injury. The first author is Brian Raftrey, and the corresponding author is Kristy Red-Horse from Stanford University. Coronary artery disease occurs when blood vessels supplying the heart develop atherosclerotic plaques that limit blood flow, which prevents oxygen and nutrients from reaching the cardiac tissue and often leads to a heart attack or cardiac arrest. The suggested strategy for treating coronary artery disease is to promote the growth of new blood vessels to compensate for the dysfunctional ones. Several factors are known to control coronary blood vessel development, including the transcription factor, DACH1. In mice lacking DACH1, embryonic coronary artery development is stunted. But whether increasing DACH1 protein levels boosts heart vessel development, and whether this would work in mirroring coronary arteries, were unanswered questions. Cindy St. Hilaire: This group engineered inducible gain-of-function DACH1 mice and found that DACH1 over expression in the embryo boosted coronary artery development. The team then used the same model to induce DACH1 in adult mice for six weeks. While there was no apparent differences in the artery growth between the animals and the controls under normal conditions, after myocardial infarction, the mice over expressing DACH1 had better recovery and survival with increased artery growth and heart function. The results paved the way for studying the mechanisms of DACH1-mediated protection, and how they might be leveraged as potential coronary artery disease treatments. Cindy St. Hilaire: The second article I want to share is titled Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging. The first author is Hongxia Zhang, and the corresponding author is Kunlin Jin from University of North Texas Health Science Center. Aging is associated with declining tissue function and an assortment of health issues. But in rodents at least, certain factors, including the plasma of youthful animals and the exosomes of stem cells, can have rejuvenating effects on old animals. Exosomes are small membrane-bound particles containing cellular contents that circulate in the blood after they're released from cells. This group has shown that as rats age, the animals' serum exosomes accumulate pro-inflammatory mediators, such as C3a and C3b. Cindy St. Hilaire: When these aged rats were subjected to stroke, and then injected with serum exosomes isolated from either old or young rats, those receiving youthful exosomes fared much better in terms of infarct size and sensory motor deficits, while those receiving aged exosomes fared worse. The team went on to show that injected exosomes accumulate at the site of stroke injury, but those from old donors caused more neuronal damage, as seen by reduced synaptic function. Preventing C3a activity on microglia reversed the effects of the old exosomes and improved stroke outcome, suggesting that such modulation of inflammatory molecules might be a treatment strategy for stroke. Cindy St. Hilaire: The next article I want to share is titled Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health. The first author is Brian Joyce, and the corresponding author is Donald Lloyd-Jones. And they're from Northwestern University. DNA methylation is an epigenetic modification that regulates gene transcription. Studies of young and old individuals have shown that at certain locations in the genome, methylation status is highly correlated with age. These methylation patterns are also linked to measures of cardiovascular health, including blood pressure, cholesterol level and body mass index. This suggests that if a person has particularly good or particularly poor cardiovascular health, their DNA may appear younger or older than the individual's actual age. Cindy St. Hilaire: This group tested the hypothesis that people with poor cardiovascular health exhibit methylation changes more commonly found in elderly individuals than those with good cardiovascular health. And if so, DNA methylation patterns might be useful for predicting future cardiovascular risk. Cindy St. Hilaire: The team examined DNA methylation of over a thousand individuals enrolled in a prospective heart health cohort, testing them around age 40 and then again at around age 45. Changes in methylation status were then compared to individuals' cardiovascular health scores over a longer period. Sure enough, faster epigenetic changes did correlate with poor cardiovascular health later in life. Data from the second cohort of individuals supported the initial findings. This study indicates that DNA methylation status may be an early biomarker that signals cardiovascular issues, and may therefore allow for prompt implementation of treatment and prevention strategies. Cindy St. Hilaire: The last article I want to share is titled, Yap Promotes Noncanonical Wnt Signaling from Cardiomyocytes for Heart Regeneration. The first author is Shijie Liu, and the corresponding author is James Martin. And they're from Baylor College of Medicine. After a heart attack, cardiomyocytes are destroyed and replaced with a fibrotic scar that interferes with the contractile function of the heart. While adult mouse and human hearts are similar in this regard, the hearts of newborn mice possess greater regenerative capacity, and this regeneration capacity persists for approximately one week. The transcription factor YAP is known to regulate regenerative processes in neonatal hearts of mice. And its deletion eliminates regeneration, and its over-activation in adult cardiomyocytes reduces fibrosis. Cindy St. Hilaire: These experiments suggest cardiomyocytes transmit signals to cardiac fibroblasts. Wntless protein regulates the release of Wnt signaling molecules and also is a target of YAP. Mice that lack Wntless in their cardiomyocytes appear to have normal heart development and function. However, their neonatal regenerative capacity was impaired. In the weeks after heart injury, the mice that lack Wntless had reduced heart function, increased scar size and increased numbers of activated cardiac fibroblasts compared with that seen in controls. The study indicates that Wntless is critical to the regeneration of cardiac tissue, and may perhaps be leveraged to minimize scarring after heart attacks. Cindy St. Hilaire: I'm really excited to have with me today the three finalists of the BCVS Outstanding Early Career Investigator Award. The first person I'm going to be speaking with is Jiangbin Wu, who is a research assistant professor at the Aab Cardiovascular Research Institute at the University of Rochester. Thank you so much for joining me today. Jiangbin Wu: Thank you. Cindy St. Hilaire: And congratulations, actually. I know this is a highly competitive award that gets a lot of applications, so congrats on becoming a finalist. Before we get to your abstract, which is related to mitochondria and calcium influx in cardiomyocytes, I was wondering if you could share a bit about yourself. Maybe what your research path was, and what brought you to study cardiomyocytes and the mitochondria that are within them? Jiangbin Wu: Yeah. Right now, I'm an assitant professor at Cardiovascular Research Institute of University of Rochester. Previous, I was actually studying in the cancer field and also some kind of mitochondria work in some cancer cells. Although when I came to the University of Rochester and I switched to cardiovascular and then we are working on a kind of microRNA[at the initial. The way we screen for these is just by doing the RNA-Seq is target the microRNA. and then we start to study the function of these genes, and found that it's a mitochondria calcium channel regulator. Cindy St. Hilaire: The title of your abstract is FAM210A Maintains Cardiac Mitochondrial Homeostasis Through Regulating LETM1-Dependent Calcium Efflux. So before we unpack what all those words in the abstract title mean, could you tell me how you ended up focusing on FAM210A? What does this protein do, and why'd you focus on it? Jiangbin Wu: Yeah. As I mentioned that we just gathered this protein actually is by some kind of chance as a microRNA target. And this protein full name is family with similarity 210 A, actually is a family of proteins. This is just one of them. And the way discover is localized in mitochondria in the membrane. And also, there is some other people's report is in mitochondria. And we want to sort out its function inside the mitochondria and in the cardiac background. So we do some kind of omics or mass spec to get its interlocking interacting proteins. And then we found LETM1. It's a calcium channel inside the mitochondria in the membrane. So we figured out is, this FAM210 protein regulate LETM1 function in calcium, pump calcium is part of the mitochondria matrix. And I think this is a very important, because calcium overload is always happening in the very heart of the cardiomyocytes. Cindy St. Hilaire: That's a perfect segue, because my next question was really what is the gap in knowledge that your study was trying to address? Were you really focused on just the function of this one protein, or what was the greater goal of this study? Jiangbin Wu: Actually, the function this protein is the initial step. Our final aim is to use this protein, to over expression this protein in the heart failure patient or in some kind of heart failure models to do the, sort of do the work in some heart failure patients. Cindy St. Hilaire: Maybe a gene therapy approach, or if there's a pharmacological way to up regulate this protein? Jiangbin Wu: Yeah, because we've proposed that the self expression of this proteins will reduce the calcium overloading cardiomyocytes, which is a major cause for the cardiomyocytes death in heart failure process. So over expression will reduce this kind of process. And then it will make the cardiomyocytes survival in the failure heart. Cindy St. Hilaire: That is interesting. I mean, obviously you were using a mouse knockout model, so you know what's driving the expression down in that case. But in humans, what do we know about the regulation of this protein? Is anything known, or any known causes that cause its reduction in expression? Jiangbin Wu: Actually, we do. Its expression in heart failure is slightly increased in heart failure. So we feel it's a kind of some kind of compensating effect to try to save the heart from failing. Cindy St. Hilaire: Interesting. It's just not turned on early enough, in that case then. Jiangbin Wu: Yeah. And for the regulating protein for this one, I think we find microRNA can suppress its expression, but not too many other influences on these regulator proteins. Cindy St. Hilaire: That is so interesting. So what's next? What are you going to do next on this project? Jiangbin Wu: Yeah. I think currently, we are just at the start to do some kind of therapeutic effect that use to these proteins. I think we will do more deep in the therapeutic effects for over expression of these genes in... Currently, we are working on mouse models. Maybe in different heart failure models to prove that it's very benefiting to the heart failure patients. Cindy St. Hilaire: Wonderful. Well, congratulations on an excellent study. Really looking forward to your presentation, which is coming up shortly, and really looking forward to your future research in this field. Jiangbin Wu: Okay, thank you. Cindy St. Hilaire: So I also have with me, Dr Chris Toepfer, who's another finalist for the BCVBS outstanding early career investigator award. He's a principal investigator from the University of Oxford, and his abstract is titled, Defining Diverse Disease Pathway Mechanisms Across Thick And Thin Filament, Hypertrophic Cardiomyopathy Variance. So congratulations, Chris, and thank you for joining me today. Chris Toepfer: Thank you very much. It's great to be here. Cindy St. Hilaire: Before we start to discuss your abstract, I was wondering if you could just share a little bit about yourself. Maybe your career path, and how you came to study hypertrophic cardiomyopathy? Chris Toepfer: Yeah, sure. I guess this story gets longer and longer every time somebody asks it,right, in your career? Cindy St. Hilaire: That's a good thing. Chris Toepfer: Yeah. I started out as an undergraduate in London, and actually during the second year of my undergraduate degree, I fell into a lab kind of out of interest. It was starting to study cardiac muscle mechanics. And that was the lab of Professor Michael Ferenczy. And ended up, after I finished my undergraduate degree, I joined him for a PhD. I had a PhD program that also took me overseas to the NIH to work with Dr James Sellers, who was a muscle motor protein biochemist. And we really, I sort of really fell in love, with the idea of studying disease of multiple levels, and understanding how the heart would function from the basic molecule up to the entire organ and looking at different systems in between. Chris Toepfer: And that's what led me to then, so my postdoctoral position to seek out a completely different direction in some ways, but something that could also extend how we could look at the heart. And that's where I moved to Boston to work with Christine and Jonathan Seidman. I'm looking at more of the genetic basis then of hypertrophic cardiomyopathy rather than just, sort of more diffusely the mechanisms underlying cardiac muscle contraction. And then two years ago, I moved back to the UK to Oxford to sets up my own group, which has been fun during the pandemic as you can imagine. Cindy St. Hilaire: It's hard enough starting up a lab under normal times. I can't imagine doing it during a pandemic. Chris Toepfer: And we are now completely focused on stem cell models and CRISPR CAS engineering, and trying to understand hypertrophic cardiomyopathy in a dish. Cindy St. Hilaire: That's wonderful. And actually I looked at your CV. We actually overlapped a little bit. I was doing my postdoc at NIH in the NHLBI while you were there for your graduate school. So I too fell in love with kind of the starting with the human as the model path of research. So maybe you can kind of fill in all the listeners in who aren't cardiomyopathy experts. So what is, I guess, in a nutshell, hypertrophic cardiomyopathy, and what gap in knowledge was your study specifically addressing? Chris Toepfer: So in general, about one in 500 people have hypertrophic cardiomyopathy. And for those that are genetically linked, a lot of them are in the key contractile proteins of the heart, the drive muscle contraction. And what you often see in those people is they have thickened hearts. And what happens is actually the heart begins to be too hard, and it actually relaxes very poorly in between beats. Chris Toepfer: So what we are really trying to understand in this disease and with this abstract was how are different forms of hypertrophic cardiomyopathy created? Because it can be a couple of different forms. There are different proteins involved that have very vastly different functional mechanisms within the cell. So would this, we went away, we generated some stem cell models where we could then differentiate into cardiomyocytes. Model the disease in a dish. And we made kind of a group of good methods to go and look at what was happening inside the cells. And then we could screen drugs against what's happening inside those cells, so that was kind of the idea of what we were looking at, at the time. And what's fallen out of all of that is a drug now called Melacamptin that's starting to get to the clinic, which addresses some of these underlying mechanisms we were beginning to study. So that's what I'll talk about a bit later on in our session today. Cindy St. Hilaire: It's great. One of the things you focused on in the abstract is comparing these thick and thin filament variants. What are the implications of those, I guess, in the human disease state, but also in how you could design or use your stem cells as a model, and were any of the results that you found surprising? Chris Toepfer: So I think what was the really key finding that we saw was that the thick filament variants seemed to be switching myosin, which is a molecular motor that drives cardiac muscle contraction very much to arm”ON”. And my sort of analogy to that is they're all very sort of bodybuilder like. Myosin switched on, ready to go to work causing way too much contraction. And the compound that we were using at the time Myocamptin, we could turn those off and resolve the disease. Whereas with the thin filament variants, they were operating through a completely different mechanism. And when we tried to treat them with the same compound, they wouldn't always salvage disease. So though the face of it, they look the same in the dish, in that they contracted too much, relaxed very poorly. You're clearly doing it via complete different mechanism. And that's what we're starting to dig into now. And that's what we'll be talking about. Cindy St. Hilaire: Yeah. And that's actually kind of the question I was going to finish up with you. What are the, I guess translational implications? No, yes. You're using this drug. Is that only good for thick filament-like variants? And are you going to be able to screen patients to tell which variant they have, and therefore if this or that drug might be useful? Chris Toepfer: So we're in a real golden age now for genomics where I guess patients can come into the clinic and they can be sequenced and you could maybe tell them now what might be the underlying cause of their disease. I am not a clinician, but what we, as a basic scientist can say is, well, we can go away and try and understand whether this variant you may have in your genome is causative of disease. And if it is what mechanism that may fall under, what may be causing them to have this phenotype? Chris Toepfer: And I think what we can do is we can try and then bin the subpopulations of variants, and try and find novel drugs or novel pathways that we could try and find drugs for to treat the disease, and to differentiate them from each other. So I think it's too early to say whether Mylocamptin will be able to sort this for everybody, I guess we will find out in the next years. But I think already we can start thinking about, well, what would be the next step after this? We can bring precision medicine even further. And that's, I think the goal where we're heading towards. Cindy St. Hilaire: Well, that's wonderful, and this is a wonderful abstract. I'm really looking forward to seeing the full study and your presentation later on. And thank you so much for joining. Chris Toepfer: No. Yeah. Thank you for having me. I'm really looking forward to it later on. Cindy St. Hilaire: Great. Dr Chen Gaol is the third finalist for the BCBS Outstanding Early Career Investigator Award. She's an assistant researcher at UCLA, and her abstract is titled, Functional Impact of RBFox1C in Cardiac, Pathological Remodeling through Targeted MRNA Stability Regulation. So congratulations, and thank you so much for joining me today. Chen Gal: Absolutely, thank you for having me. Cindy St. Hilaire: Before we jump into your abstract, could you share with us a little bit about your career path, and how you came to study the role of RNA binding proteins, I guess specifically in pathological cardiac remodeling? Chen Gal: Yes, I think my research over the years has been into the very basic questions, which is I'm interested in looking at how the RNA is being regulated. For example, how the RNA is being spliced, is being ideated, and how the RNA is being degraded if it's ever been translated into protein. And the second half of my research is of course, physiological driven, because I'm interested in different type of cardiac disease, starting from the traditional heart attack to the now more emerging medical need, which is the cardiometabolic disease. So I was trained as a molecular biologist. I started in molecular biology Institute at UCLA. My PhD supervisor is Dr Yibin Wang, who first introduced me to understand there is actually a whole new world of R regulation at a post-transcription level. Chen Gal: So at that time we basically utilized the R sequencing. Just look for the easiest to heart, and try to understand how these RNA are differentially spliced in the heart. And I was so interested in understanding more about a cardiology. So I decided, even if I move out to my postdoc research I still want to continue working in the heart, although at a totally different angle. And that is when I started to really try to understand different aspects of RNA regulation. So now I am starting to be a junior faculty, establishing my own lab. And I really wanted to understand more how different steps of our metabolism is regulated. Cindy St. Hilaire: Really timely research. And I really like how you are doing a great job combining extremely basic biochemical processes with advanced disease states. An extra, that's why this abstract made it as a finalist. So congrats on that. So your study was focused on the RNA binding protein, RB Fox one, which has several isoforms. And so can you tell us which isoform you were looking at, and why you were interested in that particular isoform? Chen Gal: Yes, actually I've studied about ISO form of RPFox1. It itself, is actually subject to alternative splicing, while generating one nuclear, and another simosolic isoform. Where I was a PhD student, I was very simple minded, just trying to screen for the R binding protein that actually is expressed in the diseased heart. So RBFox1 is at least at a transcriptional level, the only one that we identify to be to decreased in the fatal heart. The nuclear function, the nucelo ISO form of RPFox1 is mainly regulating alternative splicing. But it is when I was studying this nuclear function of the RBFox1, I identified there is actually another isoform where she is in the set ourselves based on the different of c terminal domains of the RFox1. So I was just wondering, apparently you shouldn't be regulating and splicing anymore. I just move on to another layer of RA regulation. And then what I found most interesting is these RBFox1 is regulating the R stability, which is something that we'll talking about later today. Cindy St. Hilaire: That's great. So to do this study, you actually created a new knockout mouse model where you specifically deleted this one C isoform. What was kind of the baseline and maybe the disease state phenotypes that you saw in that mouse? Chen Gal: The result and phenotype so far is very striking. We utilize the CAS nine CRISPR technology simply because for, we were lucky the settle the Fox warehouse, one extra axon. So that does allow us to coach the lox P side, just blanking in that particular AXA. And in theory we could across it with different CRE, and to generate either cardiac or different tissue, specifically knock out. Even at a baseline we see a decreased cardiac function when we inactivate this isoform in the adult heart. And when we look at the gene expression profile is, I call mind-blowing type of experience, because turns out this gene not only is regulating some of the inflammatory genes, but also is helping involve protein translation and delivery metabolism, which I hope in the future will set us on the path to really understand the role of this RP Fox1. Not only into HFpEF, but also in the cardiometabolic disorder. Cindy St. Hilaire: Yeah, that's great. It's so rewarding when you do this one really big kind of risky experiment, and it turns into not just one interesting path to study, but multiple. One of the things that you mentioned in the abstract is clip seek. I was wondering if you could tell us a little bit about this technology, and how you used it in your study? Chen Gal: Yeah. I think one of the rewarding parts for me focusing on the R metabolism is really driving different accounting and sequencing tools, and utilize that in the heart. So cardiomyocyte has been traditionally viewed now to be very easy to work with type of model comparing helo cells, right? And I think in the field, we are still so short of knowledge, what type of the cutting-edge tools that we can use in the heart. My research involved clip seek, which is to use UV crosslinking the RNA with the R binding protein. So that will allow us to understand which are the RNA targets that are directly interacting with the RNA binding protein. I'm also using great seek, which is to find dynamically label the recency size to RNA. And that will allow us to look forward to RA degradation profile at a global level in the baseline or under disease. So I thought those are really cool technologies, and that's something that makes me excited about my work on a daily basis. Cindy St. Hilaire: Yeah, that's wonderful. So what's next? What are you going to do after this initial study? What's the next question you're going to go after? Chen Gal: Yeah, like I mentioned, I'm interested in, honestly, different type of heart disease, not just the stress induced heart failure, but also the recent years, I started to branch out a little bit to understand more of the biology of HFpEF. For example, how the R binding protein that we are studying right now is playing a role in the development of HFpEF. Or we actually understand very little about them, the micromechanism for HFpEF development, right. What are the RNA splicing profile in the cardio metabolic disorder on account? We also find differential regulation of R stability in the HfPEF compared to the HFpEF compared to the HFrEF. So I thought those are really interesting questions that I would like to pursue in the future. Cindy St. Hilaire: That's great and best of luck in those future studies. Chen Gal: Thank you. Cindy St. Hilaire: Before we leave, I was wondering if you could share with us any advice that you would give to a trainee, maybe something that you wish you knew ahead of time in this kind of early career stage. Chen Gal: I consider myself a really, really lucky person. And if I have one word to give to the younger people, younger than me, is to find great mentors for your career. And luckily our field has a lot of good mentors who are ready to help us every single step of our career. For example, my PhD supervisor, Dr Wang. And I have met a lot of good mentors inside and outside of UCLA. I'm pretty sure this is the same thing for Chris, who is trained by Dr Seidman, and everybody know how great a mentor she is. So I think having a great mentor will help you every step of your career development to making sure you're always on the right track. And that, that is also something that you will do when we have our own lab, because we want to be great mentors for our trainees as well. Cindy St. Hilaire: I know. That's something I strive for too, is to emulate my amazing mentors that I've had. What do you think is a good quality for a good mentor? Like what's one of the, I guess key features that you look for in someone that you would like to be your mentor? Chen Gal: For me, I think my mentors are all cheerleaders. They never try to push me to move out one career path versus the other. They are good listeners, and they are also my role models. Cindy St. Hilaire: That's wonderful. Chris, what's a piece of advice that you would like to share with trainees that your former self wish you knew of? Chris Toepfer: I think it's very important to echo the message of a good mentorship, and a good lab environment that allows you to flourish and really helps you to grow yourself to the future. And also helps you understand the bits of you that you could actually grow as well, a little bit better. So you become a more rounded scientist. I think something that's really important or something that I've always found very infectious is to find mentorship and mentors that are also incredibly enthusiastic about you as an individual, as well as the science. I think that that can really drive you. And I think that's also an important thing to have in yourself, to have, to find that question for yourself that really drives you and you can be really enthusiastic about. Cindy St. Hilaire: I totally agree. Well, thank you again for joining me today. Congratulations on being a finalist, and I wish everyone the best of luck in their presentations later on at BCBS. Chen Gal: Thank you so much. Jiangbin Wu: Thank you. Chris Toepfer: Thank you very much. Cindy St. Hilaire: That's it for the highlights from the September 17th and October 1st issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page, and follow us on Twitter and Instagram with the handle @CircRes and #Discover CircRes. Thank you to our guests, BCBS Outstanding Early Career Investigator Award Finalists, Dr Jaobing Wu, Dr Chen Gal, and Dr Chris Toepfer. And a special congratulations to Dr Toepfer who won this year's competition. This podcast is produced by Asahara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of circulation research. Some of the copy texts for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire. And this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American heart association, 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American heart association. For more information, please visit AHAjournals.org
The nature of work had already been changing long before the global pandemic accelerated trends around flexible work, remote work technology, and the gig economy. While some industries and workers have benefitted from these changes, others have been left behind - including many women who dropped out of the workforce due to family concerns, or service-industry professionals whose jobs evaporated. The latest episode of Living Beyond Borders, a special podcast series from GZERO brought to you by Citi Private Bank, looks in depth at the future of work and how the latest trends will change business, the economy, and the global political balance. Moderated by Caitlin Dean, Head of the Geostrategy Practice at Eurasia Group, this episode features Ida Liu, Global Head of Private Banking at Citi Global Wealth and Alexander Kazan, Chief Commercial Officer at Eurasia Group.
This episode of Alpha Trader podcast features hosts Aaron Task and Stephen Alpher speaking with Brue Liu, CEO at Esoterica Capital, and portfolio manager of the Esoterica Thematic ETF Trust (WUGI). Among the topics discussed: 5G technology is much more than just an upgrade from 4G, says Liu. If one thinks of 4G as enabling the mobile internet, 5G will allow the digitization of every aspect of our lives - from streaming to smart homes to smart factories to remote healthcare to self-driving cars. Another difference - if 4G was mostly a U.S. phenomenon, 5G is global. The evolution to 5G technology will first be felt in semiconductors as all devices will require upgrades. Among Esoterica's top ten holdings are Nvidia (NVDA), Xilinx (XLNX), Marvell (MRVL), Qualcomm (QCOM), Advanced Micro Devices (AMD), and Taiwan Semiconductor (TSM). Speaking of the recent crackdown by Beijing on China's large tech companies, Liu says these regulatory developments have been a long time coming. The country's leadership has long felt the tech giants have been extraordinary beneficiaries of hyper-growth, and now it's time to share some of the wealth, says Liu. As recently seen with Meituan (MPNGF), the companies will reach a settlement with the government, agree to changes, pay a fine, and move along. Learn more about your ad choices. Visit megaphone.fm/adchoices
This week we talked about the boys in Robert Jordan's The Path of Daggers, but we didn't have a ton to say about the boys, so we talked about Elayne, too. Laura shares her latest binges and wishes more authors would incorporate playlists into their books. Hannah has been taking it easy, but talks about a romp of a book she recently read and reflects on studying during Law School. Then Laura quizzes Hannah about her recent library HAUL, and we both gush over libraries and The Umbrella Academy.PS: GO CHECK OUT HANNAH'S YOUTUBE DEBUT ON LITERATURE & LOFIMedia Mentions:The Wheel of Time series by Robert JordanAct Your Age, Eve Brown by Talia HibbertYou---NetflixYou by Caroline Kepnes and narrated by Santino FontanaCrazy Ex-Girlfriend---NetflixFrozen---Disney+Beach Read by Emily HenryThe Godfather by Mario PuzoLaw & Order---PeacockGideon the Ninth by Tamsyn MuirThe Mountains Sing by Nguyen Phan Que MaiFlowers for the Sea by Zin E. RocklynMonstress by Majorie M. Liu and Sana TakedaLeviathan Wakes by James S.A. CoreyStar Trek---HuluOne of Us is Lying---PeacockOne of Us is Lying by Karen M. McManusFiction Fans PodcastLiterature & LoFi on YouTubeWatchmen by Alan Moore and Dave GibbonsWatchmen---HBOmaxMaster of Djinn by P. Djeli ClarkQuit Like a Woman by Holly WhitakerShuggie Bain by Douglas StuartHamnet by Maggie O'FarrellBefore They are Hanged by Joe AbercrombieThe Lord of the Rings by JRR TolkienA Burning by Megha MajumdarDark---NetflixSaved by the Bell---PeacockThe Umbrella Academy---NetflixJade City by Fonda LeeMisfits---HuluNicky, Ricky, Dicky & Dawn---NetflixThe Twilight Saga by Stephenie Meyer
Three parents came to Chasing Encounters podcast to share their experiences about being graduate students and how their families supported them throughout their journey. We discussed how rewarding is when they feel the support of their children in difficult times. * Biography: Meng Xiao is a scholar on international student engagement and the founder of Dream X Education Inc., an educational agency supporting international students engaging in North America. Latifa Soliman is a faculty of English communication at Durham College and is proud to be teaching a diverse group of adult students who decided to re-join school after years of abandoning it, aiming to fulfill their goals and invest in their education. Yi Liu is a spiritual teacher who helps to elevate awareness, happiness & parenting skills. Her insight on spirituality stems from both Chinese and western wisdom. Cite this podcast (APA): Ortega, Y. (Producer). (2021, October 20). CES6E1 – parenting while being a graduate student. https://soundcloud.com/chasingencounters/ces6e1-parenting-while-being-a-graduate-student * Sources: Xiao, M., Liu, Y., Soliman, L., & Chudaeva, E. (2021). Being a Parent—Rethinking Parenting Philosophy from Global Perspectives (X. Qian, Ed.). Dream X Education.
Yilong Liu's The Book of Mountains and Seas is a buddy romp through New York City... about grief! Liu's sense of humor shines through in this script. Listen in as Jackson and Jacob discuss the juxtaposition of myth and modernity this week. ------------------------------ Please consider supporting us on Patreon. For as low as $1/month, you can help to ensure the No Script Podcast can continue. https://www.patreon.com/noscriptpodcast ----------------------------- We want to keep the conversation going! Have you read this play? Have you seen it? Comment and tell us your favorite themes, characters, plot points, etc. Did we get something wrong? Let us know. We'd love to hear from you. Find us on social media at: Email: noscriptpodcast@gmail.com Facebook: https://www.facebook.com/No-Script-The-Podcast-1675491925872541/ Instagram: https://www.instagram.com/noscriptpodcast/ Twitter: https://twitter.com/noscriptpodcast/ ------------------------------ Our theme song is “Upbeat Soda Pop” by Purple Planet Music. Credit as follows: Music: http://www.purple-planet.com ------------------------------ Thanks so much for listening! We'll see you next week.
Show #1248 If you get any value from this podcast please consider supporting my work on Patreon. Plus all Patreon supporters get their own unique ad-free podcast feed. Good morning, good afternoon and good evening wherever you are in the world, welcome to EV News Daily for Monday 18th October. It's Martyn Lee here and I go through every EV story so you don't have to. Thank you to MYEV.com for helping make this show, they've built the first marketplace specifically for Electric Vehicles. It's a totally free marketplace that simplifies the buying and selling process, and help you learn about EVs along the way too. TESLA STARTS DELIVERING REFRESHED MODEL X TO CUSTOMERS "Tesla delivered its redesigned Tesla Model S interior in early 2021, and now Model X buyers are finally getting their turn. Electrek and TMC forum member Sunnyvaletree report that Tesla has started delivering the revised Model X to customers, holding at least one event to mark the occasion." reports engadget: "As you might guess, this effectively drags the electric crossover into the modern era with a landscape touchscreen display up front, a smaller display in the back and overall interior quality improvements that are more befitting a nearly $94,000 vehicle. Order a Model X Plaid as of this writing and you'll have to wait until July 2022; spring for the lower-cost Long Range variant and you'll wait until September 2022. It could be a long, long while before you can simply buy the current Model X design and expect to receive it in a timely fashion." Read more: https://www.engadget.com/tesla-model-x-refresh-delivery-date-173928922.html MATE RIMAC HAS BIG, ELECTRIC PLANS FOR BUGATTI "In 2008, Mate Rimac replaced the broken engine of his ageing BMW race car with an electric motor from a forklift truck. Today, the Croatian is the founder and chief executive of Rimac Automobili, a producer of electric hypercars and electric vehicle (EV) drivetrains sold to some of the world's most prestigious carmakers. He is also about to become the CEO of Bugatti, at the age of 33." says Wired: "Once the takeover of Bugatti is complete, Rimac Automobili will share ownership of the historic French brand in a 55/45 split with Porsche. Mate will become CEO of the newly formed Bugatti Rimac. Despite taking on such a healthy brand, Rimac wants to shake things up “by developing cars that are very different.” As well as a hybrid successor to the mighty Chiron, Rimac has plans to expand Bugatti's vehicle lineup for the first time in generations." Mate says: "I picture it in a way that we have the campus built, that we ship cars every week to customers all around the world, are a leader in high-performance cars, and have truck-loads of batteries and powertrains going to OEMs every day. That's when I see ‘chapter one' closed.”" Read more: https://www.wired.co.uk/article/mate-rimac-bugatti POST-BREXIT BOOST: FORD PICKS UK FACTORY OVER GERMANY FOR £200M ELECTRIC CAR INVESTMENT "Ford will boost Britain's automative industry by making electric car components at its factory in Halewood. The car company selected the Merseyside site over one of its plants in Germany for a £200m investment into its e-Drive transmission systems. The systems control power from batteries used to run a vehicle's wheels." reports City AM: "The deal secures the future of the 500 staff members working at the site. They currently make transmissions for petrol Ford vehicles including the Fiesta and Focus, which are then exported to manufacturing plants in Europe." Read more: https://www.cityam.com/ford-chooses-uk-factory-for-200m-electric-car-transmission-plans/ APPLE'S IPHONE PARTNER FOXCONN UNVEILS FIRST ELECTRIC VEHICLES "Foxconn Technology Group unveiled its first electric vehicles, a milestone that could boost the Taiwanese electronics manufacturer's credentials as a serious bidder for Apple Inc.'s secretive automotive project." writes Bloomberg: "The SUV and sedan models introduced on Monday are concept vehicles that the manufacturer plans to build for automotive customers rather than sell under its own brand. Executives including Young Liu, chairman of Foxconn's flagship unit Hon Hai Precision Industry Co., unveiled the vehicles at the company's Technology Day event in Taipei. Taiwan's Yulon Motor Co. will be Foxconn's first electric-car customer, Lilian Chen, Yulon's chairwoman, said at the Taipei event. Yulon's electric sedan built by Foxconn is set to retail for less than NT$1 million ($35,700,) Liu said" Reuters said: " Autos could ring in roughly $35 billion in sales for Foxconn in five years, executives boldly predicted, and the company has already set a lofty target of supplying components or services to 10% of the world's battery-powered vehicles by 2027. Yesterday's new models, including an electric bus, are expected to hit the market in Taiwan as early as 2022. The aim is to be able to service auto customers and partners, which already include U.S.-based Fisker (FSR.N) and China's Geely, closer to their end users. Foxconn still has a long way to go, but it's a promising start so far." Read more: https://www.bloomberg.com/news/articles/2021-10-18/apple-s-iphone-partner-foxconn-unveils-first-electric-vehicles Read more: https://www.reuters.com/breakingviews/foxconn-cars-powered-by-both-hype-substance-2021-10-19/ RIVIAN R1T CUSTOMER CARS ARE COMING "Rivian R1T spotted on John Kilpatrick turnpike in Oklahoma City on October 15, 2021 at 4:41pm. The first Rivian R1T was blue and the second was white. I was unable to tell the interior colors." - SirIceberg on Youtube STELLANTIS, LG ANNOUNCE JOINT VENTURE TO PRODUCE EV BATTERIES IN NORTH AMERICA "The maker of Jeep SUVs and Ram pickup trucks on Monday said it has entered into a memorandum of understanding with LG Energy Solution to create a joint venture for the production of electric-vehicle battery cells and modules in North America." according to The Detroit News: "The joint venture between Stellantis NV and the Korean battery maker intends to break ground in the second quarter of 2022 on a battery plant for hybrids and EVs assembled in the U.S., Canada and Mexico. The plant will have an annual production capacity of 40 gigawatt hours with the goal of starting production by the first quarter of 2024." The report adds: "In Europe, Stellantis has partnered with French oil and gas company TotalEnergies SE and Daimler AG's Mercedes-Benz for its Automotive Cells Co. joint venture. A total of three battery plants are planned in France by 2023, Germany by 2025 and Italy by 2030. Altogether, they represent 120 gigawatt hours in annual capacity." CNBC points out: “The batteries produced at the new facility will be supplied to Stellantis' electric vehicle plants in the United States, Canada and Mexico, to support Stellantis' goal of having more than 40% of its U.S. sales consist of e-vehicles by 2030. The plant is targeted to start by the first quarter of 2024 and aims to have an annual production capacity of 40 gigawatt hours." Read more: https://eu.detroitnews.com/story/business/autos/chrysler/2021/10/18/stellantis-lg-energy-solution-joint-venture-electric-vehicle-batteries-north-america/8503651002/ Read more: https://www.cnbc.com/2021/10/18/stellantis-lg-energy-solution-to-form-battery-production-jv-for-us-market.html EQE CROSSOVER STYLING GLIMPSED IN GERMANY "About a year from now, Mercedes-Benz is expected to launch the battery-electric EQE crossover, to be built at its Alabama plant. It will be slightly smaller than the EQS SUV, also coming next year." says Automotive News Europe: "The EQE crossover and sedan, which is due in 2022 as well, are similar in size and market segment as Mercedes' E-Class cars and crossovers, while the EQS SUV and sedan, launching this fall, slot above and are intended to be the electric equivalent of the company's flagship S-Class vehicles. The EQE vehicles are built on a Mercedes-Benz scalable and flexible EVA platform and are expected to spawn several models, including rear-wheel-drive and all-wheel-drive dual-motor variants that will offer at least two battery pack options." Read more: https://www.autonews.com/cars-concepts/mercedes-benz-eqe-crossover-styling-glimpsed-germany NEW QUESTION OF THE WEEK WITH EMOBILITYNORWAY.COM When buying a used electric car, how do you feel about servicing? Do you want the previous person to have been back to a dealer every year? Do you care? Some manufacturers like Tesla don't even have a service schedule so how do you feel about buying a used EV and it's service history, or lack of. Email me your thoughts and I'll read them out on Sunday – hello@evnewsdaily.com It would mean a lot if you could take 2mins to leave a quick review on whichever platform you download the podcast. And if you have an Amazon Echo, download our Alexa Skill, search for EV News Daily and add it as a flash briefing. Come and say hi on Facebook, LinkedIn or Twitter just search EV News Daily, have a wonderful day, I'll catch you tomorrow and remember…there's no such thing as a self-charging hybrid. PREMIUM PARTNERS PHIL ROBERTS / ELECTRIC FUTURE BRAD CROSBY PORSCHE OF THE VILLAGE CINCINNATI AUDI CINCINNATI EAST VOLVO CARS CINCINNATI EAST NATIONAL CAR CHARGING ON THE US MAINLAND AND ALOHA CHARGE IN HAWAII DEREK REILLY FROM THE EV REVIEW IRELAND YOUTUBE CHANNEL RICHARD AT RSEV.CO.UK – FOR BUYING AND SELLING EVS IN THE UK EMOBILITYNORWAY.COM/
The neurons behind acupuncture's effect on inflammation, and how antibiotics affect gut bacteria.In this episode:00:54 The neuronal basis for acupuncture's effect on inflammationIn mice, electroacupuncture has been shown to reduce inflammation, but only when certain points on the body are stimulated. Why this is has puzzled scientists, but now, researchers have identified the specific neurons that are involved. They hope that this knowledge could be used in future to help treat certain inflammatory-related diseases.Research article: Liu et al.News and Views: Electroacupuncture activates neurons to switch off inflammation07:28 Research HighlightsThe Aztec origins of an obsidian ‘spirit mirror', and the damage done by a Soviet plutonium complex.Research Highlight: A ‘spirit mirror' used in Elizabeth I's court had Aztec rootsResearch Highlight: Cold-war spy pictures reveal a Soviet nuclear ‘cloud generator'10:18 Assessing antibiotics' collateral damage.Antibiotics are known to cause damage to the communities of bacteria that live in our guts. To better understand why this happens, a team has mapped the effects that different antibiotics have on individual gut-bacteria species, which may offer new insights into preventing this collateral damage.Research article: Maier et al.17:32 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, the latest species to be declared extinct in the US, and a potential planet that orbits three stars.New York Times: Protected Too Late: U.S. Officials Report More Than 20 ExtinctionsNew York Times: This May Be the First Planet Found Orbiting 3 Stars at OnceSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. See acast.com/privacy for privacy and opt-out information.
每日英語跟讀 Ep.K217: About the US - Shang-Chi actor's past work as Shutterstock model goes viral 漫威最新電影《尚氣》近期在美國勞動節長假中於短短三日內榮登北美票房冠軍，而亞裔男主角劉思慕也憑藉精湛的演出獲得國際讚賞。 Marvel's latest movie “Shang-Chi and the Legend of the Ten rings” broke box office records in the U.S. during the Labor Day weekend, with lead actor Simu Liu (劉思慕) receiving praise for his stellar performance. 然而，粉絲近期卻意外的挖到了劉思慕成為漫威英雄前擔任Shutterstock圖庫模特兒的照片，超有喜感的照片也讓許多網友大讚是「最強蛻變」。 Amid soaring popularity, fans of the movie recently unearthed photos of Liu's previous work as a model for Shutterstock, leading to many lauding it as the biggest “glow up” ever. 推特帳號Boss Logic於週二分享了四張Shutterstock圖庫照，在一張張看似普通的公司同事互動示意圖片中，竟發現劉思慕站在其中的身影，還面露微笑。 Twitter account Boss Logic recently shared four photos of Liu on Shutterstock that seemed to be illustrating colleagues and office work. Boss Logic於貼文中開玩笑的寫道，「我想應該沒有比從Shutterstock到漫威更強大的蛻變吧」同時也標記了劉思慕和漫威推特帳號。 Boss Logic jokingly commented “I don't think there is a bigger glow-up than from Shutterstock to MarvelStudios,” whilst tagging both Marvel and Liu in the post. 網友一看到照片全都笑瘋，立即在留言區表示「新的『永恆族』演員劇照曝光」。 Amused social media users immediately took to the comment section to voice their amusement, with some saying the people in the stock photos are the new “Eternals,” the next Marvel movie to hit the big screen. 也有網友將復仇者聯盟剪貼到Shutterstock照片中，只見「尚氣」正經八百的穿著上班族服裝(襯衫和西裝褲)，而其他角色則全副武裝，圍著辦公室會議桌的樣子顯得更加荒謬。 Others photoshopped the “Avengers” into the Shutterstock photos, showing Liu in a business-casual suit while the other characters appeared fully dressed in their standard outfits, gathered around a conference table. 不少人大讚這些照片實在太令人驚豔，甚至有網友挖出更早前劉思慕替加拿大一家連鎖速食店拍人事招募的海報。 Many called the photos “incredible” while one social media user even dug up an old recruitment advertisement seeking workers for a Canadian fast-food chain that also featured the Marvel star. 好笑的貼文也讓網友坦言從Shutterstock到最終成為漫威第一位亞裔英雄極具啟發性。 The funny tweet has left some feeling “inspired” as Liu's past work experience ultimately led to him landing the lead as Marvel's first Asian American superhero. 劉思慕爾後也拿了其中一張圖在自己的推特帳號上開玩笑的寫道，「我笑那些以為『尚氣』會表現很差的人」。 Next Article 川普小兒子準備上高中！超豪華私校開十年就爆醜聞 Barron Trump enrolls in prestigious but controversial private school, Oxbridge Academy 隨著2021學年實體課程的恢復，前美國總統川普的小兒子拜倫(Barron Trump)也將在佛羅里達州棕櫚灘的超豪華私校迎接新學期。 With in-person lessons coming back for the 2021 school year, Barron Trump, the youngest son of former U.S. President Donald Trump, is also starting the new semester at a prestigious school located in Palm Beach, Florida. 今年15歲的拜倫將以新生身分入學Oxbridge Academy (津橋學院)，而這所地位顯赫的學校一學年學費竟需要價近3.5萬美元(近新台幣97萬)。 The 15-year-old will be attending Oxbridge Academy as a freshman, and the yearly school fee is priced at a whopping US$35,000 (around NT$970,420). 根據外媒People報導，該校的規畫總監史考特‧塞格佛略德(Scott Siegfried) 表示，「我們非常期待歡迎拜倫加入我們的學校和校園團隊。」 According to People, the school's Director of Advancement Scott Siegfried said: “We look forward to welcoming him [Barron] into our school and community.” 津橋學院的家長們也於近期收到學校寄來的電郵，信件中表示美國特勤局的人員也將會隨著拜輪的加入在校園中出沒。 Parents also received emails from the school notifying them that secret service members would be present on campus following Barron Trump's enrollment. 這個於2011年創校的學院，擁有有特廚準備的午餐，帆船和馬術校隊，以及人工智慧和航空相關課程。 Founded in 2011, the school boasts chef-prepared lunches, a sailing and equestrian team, and artificial intelligence as well as aviation programs. 據《太陽報》報導，這所私校同時要求所有學生都要擁有一台蘋果筆電，同時還在校園中提供飛行模擬器供學生使用。 A flight simulator is also provided, though all students are required by the school to have an Apple Laptop, The Sun reported. 雖然此校聲望很高，然而《太陽報》也點出該校於2015年起醜聞不斷；首先為校園書店店長Ulle Bohsko控告當時執行長Robert Parsons性騷擾。 Though prestigious, the publication pointed out that the school was previously embroiled in a scandal in August 2015, when a bookstore manager Ulle Boshko filed a sexual harassment claim against then CEO Robert Parsons. Boshko爾後被迫離職指控是因為當時提出的控訴才被解雇。 Boshko was later fired and claimed that the termination was due to her accusations. 隨後，《紐約時報》也於2016年報出該校創辦人William Koch在一個採訪中表示學校裡的「權力菁英團隊」掌管著這所「精神病院」。 The New York Times also claimed in 2016 that founder William Koch said in an interview. “power elites group” in the school ran “the asylum.” 在結束總統任期後，前美國總統川普搬遷到佛羅里達州，目前宅邸為海湖山莊(Mar-a-Lago)，也是川普於1985年購買的私人會員製俱樂部。 Following the end of his presidency, former U.S. President Donald Trump relocated to Florida and is currently living at Mar-a-Lago, an exclusive members-only club which Trump purchased in 1985. Source article: https://chinapost.nownews.com/20210907-2756320; https://chinapost.nownews.com/20210902-2747359
At first glance, medicine and poison might seem to be opposites. But in China's formative era of pharmacy (200–800 CE), poisons were strategically deployed as healing agents to cure everything from chills to pains to epidemics. Healing with Poisons: Potent Medicines in Medieval China (U Washington Press, 2021) explores the ways physicians, religious devotees, court officials, and laypeople used powerful substances to both treat intractable illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of techniques to transform dangerous poisons into efficacious medicines. Recounting scandals and controversies involving poisons from the Era of Division to the early Tang period, Yan Liu considers how the concept of du was central to the ways people of medieval China perceived both their bodies and the body politic. Liu also examines a wide range of du-possessing minerals, plants, and animal products in classical Chinese pharmacy, including the highly poisonous herb aconite and the popular arsenic drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body's interaction with potent medicines, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University at Buffalo Libraries. Open access edition: DOI 10.6069/9780295749013. Yan Liu is assistant professor of history at the State University of New York at Buffalo. Victoria Oana Lupașcu is an Assistant Professor of Comparative Literature and Asian Studies at University of Montréal. Her areas of interest include medical humanities, visual art, 20th and 21st Chinese, Brazilian and Romanian literature and Global South studies. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine
At first glance, medicine and poison might seem to be opposites. But in China's formative era of pharmacy (200–800 CE), poisons were strategically deployed as healing agents to cure everything from chills to pains to epidemics. Healing with Poisons: Potent Medicines in Medieval China (U Washington Press, 2021) explores the ways physicians, religious devotees, court officials, and laypeople used powerful substances to both treat intractable illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of techniques to transform dangerous poisons into efficacious medicines. Recounting scandals and controversies involving poisons from the Era of Division to the early Tang period, Yan Liu considers how the concept of du was central to the ways people of medieval China perceived both their bodies and the body politic. Liu also examines a wide range of du-possessing minerals, plants, and animal products in classical Chinese pharmacy, including the highly poisonous herb aconite and the popular arsenic drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body's interaction with potent medicines, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University at Buffalo Libraries. Open access edition: DOI 10.6069/9780295749013. Yan Liu is assistant professor of history at the State University of New York at Buffalo. Victoria Oana Lupașcu is an Assistant Professor of Comparative Literature and Asian Studies at University of Montréal. Her areas of interest include medical humanities, visual art, 20th and 21st Chinese, Brazilian and Romanian literature and Global South studies. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/chinese-studies
At first glance, medicine and poison might seem to be opposites. But in China's formative era of pharmacy (200–800 CE), poisons were strategically deployed as healing agents to cure everything from chills to pains to epidemics. Healing with Poisons: Potent Medicines in Medieval China (U Washington Press, 2021) explores the ways physicians, religious devotees, court officials, and laypeople used powerful substances to both treat intractable illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of techniques to transform dangerous poisons into efficacious medicines. Recounting scandals and controversies involving poisons from the Era of Division to the early Tang period, Yan Liu considers how the concept of du was central to the ways people of medieval China perceived both their bodies and the body politic. Liu also examines a wide range of du-possessing minerals, plants, and animal products in classical Chinese pharmacy, including the highly poisonous herb aconite and the popular arsenic drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body's interaction with potent medicines, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University at Buffalo Libraries. Open access edition: DOI 10.6069/9780295749013. Yan Liu is assistant professor of history at the State University of New York at Buffalo. Victoria Oana Lupașcu is an Assistant Professor of Comparative Literature and Asian Studies at University of Montréal. Her areas of interest include medical humanities, visual art, 20th and 21st Chinese, Brazilian and Romanian literature and Global South studies. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/history
At first glance, medicine and poison might seem to be opposites. But in China's formative era of pharmacy (200–800 CE), poisons were strategically deployed as healing agents to cure everything from chills to pains to epidemics. Healing with Poisons: Potent Medicines in Medieval China (U Washington Press, 2021) explores the ways physicians, religious devotees, court officials, and laypeople used powerful substances to both treat intractable illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of techniques to transform dangerous poisons into efficacious medicines. Recounting scandals and controversies involving poisons from the Era of Division to the early Tang period, Yan Liu considers how the concept of du was central to the ways people of medieval China perceived both their bodies and the body politic. Liu also examines a wide range of du-possessing minerals, plants, and animal products in classical Chinese pharmacy, including the highly poisonous herb aconite and the popular arsenic drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body's interaction with potent medicines, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University at Buffalo Libraries. Open access edition: DOI 10.6069/9780295749013. Yan Liu is assistant professor of history at the State University of New York at Buffalo. Victoria Oana Lupașcu is an Assistant Professor of Comparative Literature and Asian Studies at University of Montréal. Her areas of interest include medical humanities, visual art, 20th and 21st Chinese, Brazilian and Romanian literature and Global South studies. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
At first glance, medicine and poison might seem to be opposites. But in China's formative era of pharmacy (200–800 CE), poisons were strategically deployed as healing agents to cure everything from chills to pains to epidemics. Healing with Poisons: Potent Medicines in Medieval China (U Washington Press, 2021) explores the ways physicians, religious devotees, court officials, and laypeople used powerful substances to both treat intractable illnesses and enhance life. It illustrates how the Chinese concept of du—a word carrying a core meaning of “potency”—led practitioners to devise a variety of techniques to transform dangerous poisons into efficacious medicines. Recounting scandals and controversies involving poisons from the Era of Division to the early Tang period, Yan Liu considers how the concept of du was central to the ways people of medieval China perceived both their bodies and the body politic. Liu also examines a wide range of du-possessing minerals, plants, and animal products in classical Chinese pharmacy, including the highly poisonous herb aconite and the popular arsenic drug Five-Stone Powder. By recovering alternative modes of understanding wellness and the body's interaction with potent medicines, this study cautions against arbitrary classifications and exemplifies the importance of paying attention to the technical, political, and cultural conditions in which substances become truly meaningful. Healing with Poisons is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem) and the generous support of the University at Buffalo Libraries. Open access edition: DOI 10.6069/9780295749013. Yan Liu is assistant professor of history at the State University of New York at Buffalo. Victoria Oana Lupașcu is an Assistant Professor of Comparative Literature and Asian Studies at University of Montréal. Her areas of interest include medical humanities, visual art, 20th and 21st Chinese, Brazilian and Romanian literature and Global South studies. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/east-asian-studies
Episode Summary: Enzymes that break down other proteins, or proteases, could be used as a powerful therapeutic if they could specifically chew-up disease causing entities. However many proteases are non-specific, breaking any protein in their path, while the specific ones target proteins that would provide no therapeutic benefit. Travis and his colleagues developed a riff on the method known as PANCE that utilizes bacteria and bacterial viruses known as phages to evolve proteins toward a specific goal. With it, he retrains the sequence-specific protease, botulinum neurotoxin, toward new targets and away from its original ones. The novel enzymes Travis generates have the potential to not only stimulate nerve regeneration but also deliver itself to the correct cell types for a whole new type of therapy. Episode Notes:About the AuthorTravis is a postdoc who performed this work in the lab of Professor David Liu at Harvard University. The Liu lab is famous for engineering and evolving proteins that can be utilized as massively impactful tools for overcoming diverse diseases. Travis's teachers fostered a curiosity that created a passion for chemistry and ultimately led him to engineer new biochemistries. Key TakeawaysProteases are enzymes that cut up other proteins.Proteases can either be non-specific, a nuke obliterating any protein in their path, or sequence-specific, a heat seeking missile only cutting very specific protein motifs.Sequence-specific proteases that target disease causing proteins would make great drugs but therapeutically useful proteases rarely exist in nature.Travis focuses on re-engineering the sequence-specific protease known as botulinum neurotoxin so that it cuts an entirely new, therapeutically relevant protein sequence.Using a method called PANCE that utilizes bacteria and bacterial viruses (phages), Travis trains botulinum neurotoxin toward cutting a new target and leaving its original target alone.TranslationBotulinum neurotoxin has a cutting domain that Travis engineered toward a therapeutically relevant target, and a targeting domain that delivers the protein toward neurons.The enzymes generated could be used to cure neural pathologies but the PANCE could also be applied to change which cell type the protease targets, creating a highly programmable therapeutic protease platform.The platform has a ton of interest from industry and Travis is continuing to work on it outside of academia so that these proteases make it to the clinic and impact patient lives.First Author: Travis BlumPaper: Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity
The lads open the curtain on their 16th season of the show by welcoming live and online tournament and cash game player Xuan Liu. They also sit down with SNG Wizard Josh Hoesel aka SlayerV1fan. For strategy, they look at a key hand of David's from the 2009 Full Tilt Espana Series. Paul Seaton stops by to discuss staking. Plus, Ian's got all the news and results!
Shang-Chi and the Legend of the Ten Rings is a 2021 American superhero film based on Marvel Comics featuring the character Shang-Chi. Produced by Marvel Studios and distributed by Walt Disney Studios Motion Pictures, it is the 25th film in the Marvel Cinematic Universe (MCU). The film is directed by Destin Daniel Cretton from a screenplay he wrote with Dave Callaham and Andrew Lanham, from a story by Cretton and Callaham. It stars Simu Liu as Shang-Chi alongside Awkwafina, Meng'er Zhang, Fala Chen, Florian Munteanu, Benedict Wong, Michelle Yeoh, Ben Kingsley, and Tony Leung. In the film, Shang-Chi is forced to confront his past after he is drawn into his father's Ten Rings organization. A film based on Shang-Chi entered development in 2001, but work did not begin in earnest until December 2018 when Callaham was hired. Cretton joined in March 2019, with the project fast-tracked as Marvel's first film with an Asian lead. The film's title and primary cast were announced that July, revealing the film's connection to the Ten Rings organization, which previously appeared throughout the MCU, and its leader, Wenwu, portrayed by Leung. Shang-Chi and the Legend of the Ten Rings is the first Marvel Studios film with an Asian director and a predominantly Asian cast. Filming began in February 2020 but was put on hold in March due to the COVID-19 pandemic. Production resumed in August before completing in October, with additional shooting occurring in Sydney and San Francisco. Shang-Chi and the Legend of the Ten Rings premiered in Los Angeles on August 16, 2021, and was released in the United States on September 3, as part of Phase Four of the MCU. It has grossed $273 million worldwide, making it the eighth-highest-grossing film of 2021, and received positive reviews from critics, who praised the choreography of the action sequences, exploration and representation of Asian culture, and the performances from the cast, particularly Liu and Leung. --- Send in a voice message: https://anchor.fm/popcorn-junkies/message
Endangered species can be difficult to study, as they are elusive, and the very act of observing them can disrupt their lives. Now, scientists can take a closer look at endangered species by studying AI-generated 3D representations of them. Sifei Liu, a senior research scientist at NVIDIA, has worked with her team to create an algorithm that can reconstruct 3D meshes — graphics models used to display the edges, vertices and overall shape of an object — from 2D inputs like images and videos. Liu spoke with NVIDIA AI Podcast host Noah Kravitz about her team's project, called Online Adaptation for Consistent Mesh Reconstruction in the Wild. Liu and her team have presented the project at various prominent conferences, including NeurIPS 2020.
We actually got some picks correct this week! And we had a couple wins for our teams! Alabama rolls again, and at this point, they can't be stopped. Brian Kelly and Chip Kelly are related. And, we learn what LIU is, and realize they have some of the best jerseys in football. Our regularly scheduled episodes will return shortly discussing the next several seasons of college football history, but in the mean time, let's get into week 3! Be sure to leave a review, subscribe and share with your friends and family. Follow us on Twitter @DeserveANatty
C.J. & Zach join me on THE PORCH for a rewind on LIU & a preview of the Battle for the Black Diamond Trophy. We also discuss GAMEDAY attire & ghosts of quarterbacks past.
Tony Caridi and Dale Wolfley chat with Head Coach Neal Brown about the win over LIU last weekend, preparing for Virginia Tech this Saturday, the history of the rivalry with the Hokies and keys to victory this weekend. Co-Offensive Coordinator and Running Backs Coach, Chad Scott, also joins the show to talk about the success of WVU kickoff returns, preview Virginia Tech and assess the running back position through the first two weeks of the season.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Learn about non-human animals that say hello and goodbye; life on Snowball Earth; and how to learn skills twice as fast. Apes use their own form of hello and goodbye, the first time we've seen that in non-human animals by Steffie Drucker Heesen, R., Bangerter, A., Zuberbühler, K., Iglesias, K., Neumann, C., Pajot, A., Perrenoud, L., Guéry, J.-P., Rossano, F., & Genty, E. (2021). Assessing joint commitment as a process in great apes. IScience, 102872. https://doi.org/10.1016/j.isci.2021.102872 Like humans, apes communicate to start and end social interactions. (2021, August 11). EurekAlert! https://www.eurekalert.org/news-releases/924594 Schultz, I. (2021, August 11). Bonobos Appear to Say “Hello” and “Goodbye” to Each Other. Gizmodo; Gizmodo. https://gizmodo.com/bonobos-appear-to-say-hello-and-goodbye-to-each-other-1847464864 Conor Feehly. (2021). Apes Have Been Observed Starting And Ending Interactions Just Like Humans Do. ScienceAlert. https://www.sciencealert.com/apes-observed-using-purposeful-signals-to-start-and-end-interactions Life survived on "Snowball Earth" despite the ice; a new study says Earth's orbit explains why by Briana Brownell Changes in Earth's orbit enabled the emergence of complex life. (2021). EurekAlert! https://www.eurekalert.org/pub_releases/2021-07/uos-cie070721.php Mitchell, R. N., Gernon, T. M., Cox, G. M., Nordsvan, A. R., Kirscher, U., Xuan, C., Liu, Y., Liu, X., & He, X. (2021). Orbital forcing of ice sheets during snowball Earth. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24439-4 Buis, NASA's, A. (2021, February 24). Milankovitch (Orbital) Cycles and Their Role in Earth's Climate. Climate Change: Vital Signs of the Planet. https://climate.nasa.gov/news/2948/milankovitch-orbital-cycles-and-their-role-in-earths-climate/ Scientists Found a Technique That Can Help You Learn Skills Twice as Fast by Joanie Faletto first aired April 26, 2018 https://omny.fm/shows/curiosity-daily/freezer-burn-science-a-giant-flying-reptile-and-ho Follow Curiosity Daily on your favorite podcast app to learn something new every day withCody Gough andAshley Hamer. Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. See omnystudio.com/listener for privacy information.
Episode 95 is here... the boys discuss OHHS game start time issues, Justin is driving in the Homecoming parade, AP poll, weekend review, WV app sucks, LIU plusses and minuses with the obvious Greene and Doege discussion, Hokie preview and predictions, most memorable Va Tech game, most memorable Va Tech play, tailgating moments, and Mullen's finest, Jason Steele.
Hosts Dan Zangrilli and Dale Wolfley give you their first thoughts on WVU's upcoming game against Virginia Tech, as well as listen in to Neal Brown's weekly press conference and recap the Mountaineers' win last weekend against LIU. Special Teams Coordinator Jeff Koonz also joins the program. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dr. Jacqueline Swank, Associate Professor at the University of Florida, and Dr. Anita Neuer Colburn, Associate Professor at the Family Institute at Northwestern University, join Drs. Gina and Gideon to talk about their recent work developing an instrument to measure competence in supervision practice. References from this episode: Swank, J. M., Liu, R., Neuer Colburn, A. A., & Williams, K. M. (2021). Development and Initial Validation of the Supervision Competencies Scale (SCS). International Journal for the Advancement of Counselling, 1-12. Association for Counselor Education and Supervision Taskforce on Best Practices in Clinical Supervision. (2011, April). Best practices in clinical supervision. Retrieved from https://acesonline.net/wp-content/uploads/2018/11/ACES-Best-Practices-in-Clinical-Supervision-2011.pdf DeVellis, R. F. (2016). Scale development: Theory and applications (Vol. 26). Sage publications. Grant, A. (2021). Think again: The power of knowing what you don't know. Viking.
Tony Caridi and Dale Wolfley chat with Neal Brown about the loss to Maryland last week, and preview the upcoming game against LIU. Defensive Coordinator Jordan Lesley also joins the show to talk about the defense's performance in week 1 and what he hopes to see in week 2.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dan and Wolf gear up for LIU week and the WVU football home opener. Defensive line coach Andrew Jackson has deep ties to the Sharks and joins the guys to discuss. Plus, WVU men's soccer enjoys their highest national ranking since 2007. Co-captain Kevin Morris joins the pod to discuss the team's hot start.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
An unusual opponent is in what's actually the most common spot on the schedule for WVU's annual FCS opponent, but LIU doesn't have much going in its third season transitioning from Division II to the FCS. The Mountaineers ought to have their way on Saturday. Learn more about your ad choices. Visit megaphone.fm/adchoices
An argument could be made that Kent Bazemore was the most important offseason acquisition not named "Russell" or "Westbrook" for the Lakers. If nothing else, Bazemore feels like he has the highest chance of becoming the team's best two-way role player, and given how the Lakers seemingly sacrificed a lot of defense to help jumpstart the often sluggish offense during the last two seasons, any player with skills on both sides of the ball will be crucial. Is Bazemore capable of making that type of contribution? For more insight, the Kamenetzkys spoke with Sam Esfandiari and Andy Liu, who cover the Golden State Warriors as co-hosts of the Light Years podcast. They addressed questions like whether Bazemore's hot shooting in Golden State last year was real (yes), his defense meets the mark (depends on the assignment) and where his weaknesses lie (most loudly, on-court decisions). At times, Bazemore will frustrate the hell out of fans, but they'll also dig how hard he plays and his non-stop energy. If nothing else, they expect Bazemore to outplay his veteran's minimum contract by a solid margin, and is in a position to succeed with the Lakers. From there, Esfandiari and Liu assess where the Warriors currently stand in a seemingly wide open Western Conference. A lot hinges on the health of Klay Thompson, who's missed two consecutive seasons with significant injuries. But if he's back to form, they're both confident the Warriors can hang with anybody. Other teams discussed include the Denver Nuggets and Phoenix Suns. Hosts: Andy and Brian Kamenetzky SEGMENT 1: Esfandiari and Liu break down the positives and negatives of Kent Bazemore, and the often wild fluctuations in his play. SEGMENT 2: More on Bazemore, including his shooting and defensive strengths. SEGMENT 3: A look at the Warriors next season, along with a few other teams in the conference. (Plus, Everyone Loves Klay!) Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. StatHero StatHero, the FIRST Ever Daily Fantasy Sportsbook that gives the PLAYER the ADVANTAGE. Go to StatHero.com/LockedOn for 300% back on your first play. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Laura is still on her Marvel journey, and some are hits and some are definite misses. She also enjoyed a really great documentary on Netflix which sparked a good discussion on the representation of women in media. Hannah gives a great imitation of one of her favorite people, Selena Gomez, and shares how she feels about current romantic comedies. Hannah has been jamming out to Kacey Musgraves and Laura to...BTS. We break the rules this week and discuss some women along with the men because we have issues with the character portrayals in A Crown of Swords. Spoiler: Hannah still hates Gawyn.Media Mentions:
Episode 94 is here... the boys discuss Oak Hill is back on track, HS Halftime is too long, Oak Leaf Festival, attendance, gambling wins and a loss, Josh vs the mint, a look back at the disappointing Maryland game, offensive woes, defensive was fine, the obvious QB conversation, LIU preview (spooler they are terrible), who would Doege start for, more frustrating QB, worst facial hair or hair cut, and shot portions.
Dan Zangrilli and Dale Wolfley recap WVU's loss to Maryland, listen to head coach Neal Brown's weekly press conference and give their thoughts on the Mountaineers' home opener against LIU. Also, defensive coordinator Jordan Lesley and safety Sean Mahone join the show. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Simu Liu, the Chinese-Canadian actor who stars in Marvel's latest blockbuster, revealed that he was once paid $100 to be a stock photo model. Since that single photo shoot in 2014, Liu says he has seen himself on ads hawking everything from software to YMCA memberships. His advice: Think twice before doing a stock photo shoot.Also in the show: Adam Ferguson documents climate change for TIME over the course of 5 weeks, more and more photographers are publishing newsletters using tools like Substack and Facebook's Bulletin, Facebook apologizes for comparing Black men to primates, and Apple puts its child safety features on pause after experts weigh in.
People say they grow tired of superhero origin stories, but when Marvel delivers a knockout like Shang-Chi and the Legend of the Ten Rings, they change their mind. Perhaps that's because the story Marvel delivers here, under the direction of Destin Daniel Cretton, allows for the story to take precedence, regardless of the fact that it's the twenty-fifth film in the MCU franchise. It doesn't feel like they're trying to find a way to shoehorn it in. It's its own story, and is one about family first. Ocean Murff, now at the head of the table, convenes The Film Board to discuss Cretton's film. Joined by Justin Jaeger, the Board's conversation covers the story, the performances, the camerawork, the effects, and how the film is proof that Kevin Feige and the team at Marvel have a strong plan with how they continue forward. Shang-Chi: A Wuxia Film With Family at Its Core Ocean and JJ talk about the family theme at the center of this story and how that feels like such a strong way for us to meet Shang-Chi. The flashback structure gives us a chance to meet Wenwu and see his lust for glory, but also to see him give it all up for the love of Li. This romance ends up being the heart of the film, and we find a lot to unpack here. We also have side characters like Katy and Xialing. How do they work? Were they in the comics and how have they changed? Clearly, they're here for the long haul. And they both end up providing some great elements to various fight sequences. Speaking of Fight Sequences: Shang-Chi Shines Here Cinematographer Bill Pope working with Cretton helped craft some beautiful and innovative fight scenes well worth watching and discussing. JJ even compares them to Crouching Tiger, Hidden Dragon. The bus scene is great, but how about the gliding camera when Wenwu and Li first meet and battle? The CG dragon/super soulsucker fight may be a bit, well, CG, but it still looks amazing. And then there's Simu Liu. He deserves more roles because we want to see him in everything. And just like the importance of Black Panther providing a black superhero for African American audiences to identify with, Liu excels in the title role of Shang-Chi, giving him incredible conflict over his past and future decisions and creating a complex and powerful character for Asian audiences to connect with. But really, let's be honest – everyone will be able to connect to this character and to Liu. He helped push this film into the upper echelon of our MCU favorites. It's that good. So join us at the big table this month on The Film Board. It's a great chat about Shang-Chi and the Legend of the Ten Rings. Let us know what you thought! Join the conversation with movie lovers from around the world on our Discord channel! Film Sundries Learn more about supporting The Film Board and TruStory FM's family of film podcasts through your own membership — visit TruStory FM. Theatrical trailer Poster artwork Source Material Flickchart Letterboxd
Growing up in Queens, N.Y., Lucy Liu felt like she was from another planet — until she found the arts. But when the fiercely independent daughter of Chinese immigrants set her sights on acting, she was told repeatedly she wouldn't make it in Hollywood, where opportunities for Asian American talent were scant.Now she's a household name.In this crossover episode with The Los Angeles Times' “Asian Enough” podcast, the actor talks about how her memorable roles — including Ling Woo on “Ally McBeal” and O-Ren Ishii in the “Kill Bill” movies — helped move the needle on Asian representation in Hollywood. Liu also discusses why she had to stand up to Bill Murray on the set of “Charlie's Angels” and her feelings about the Destiny's Child song that name-drops her.More reading: Lucy Liu gets personal on fame, art and standing up for herself on the ‘Charlie's Angels' set
This week's Empire Podcast sees Chris Hewitt sit down with Simu Liu, the title star of the latest MCU film, Shang-Chi And The Legend Of The Ten Rings, for a wide-ranging chat (1:18:17.675 - 1:36:05.820) that takes in Liu's time in London as a teen, his prediction for Avengers 20, and a heartfelt tribute to the late Brad Allan, the film's second unit director, who passed away recently. Also this week, we bring you an excerpt (34:12.487 - 48.32.970) from James Dyer's epic spoiler-filled interview with Lisa Joy, the writer-director of Reminiscence. This, you'll be glad to know, is completely spoiler-free. The rest is available only to spoiler special subscribers shameless plug shameless plug. And in the virtual podbooth, Chris and James are joined by Helen O'Hara and, making her full debut on the podcast, Katie Smith-Wong to discuss the greatest movie scenes involving snakes (involuntary shudder), talk about the week's movie news including yet another delay for Top Gun: Maverick, and review Shang-Chi And The Legend Of The Ten Rings, Annette, and the latest Cinderella. Oh, and with four people in the booth, The Three Fact Structure makes another welcome return. And we ask the biggest question of them all: what are the bottom five MCU films? The answers may shock you. Enjoy.
Dallas Liu stars as Shuji in the Hulu series PEN15. The show is nominated for three Emmy Awards including Outstanding Comedy series. Liu can also be seen in the new Marvel film Shang-Chi and the Legend of the Ten Rings. And Netflix just announced that he will be in the upcoming live-action version of Avatar: The Last Airbender. Learn more about your ad choices. Visit megaphone.fm/adchoices
Simu Liu discusses his career, Asian empowerment and community. Actor, author and advocate Simu Liu will make his debut as the title character in Shang-Chi and the Legend of the Ten Rings. Directed by Destin Daniel Cretton and starring alongside Awkwafina, Tony Leung, and Michelle Yeoh, Liu makes history as the star of the first Asian-fronted movie in the Marvel Cinematic Universe. He also starred in the CBC/Netflix comedy series Kim's Convenience for five seasons, which was the first Canadian television series with an all-Asian lead cast and tells the day-to-day micro-dramas encountered by a Korean immigrant family that runs a corner grocery store. The series won the ACTRA Award for Outstanding Ensemble in 2017 and Best Comedy Series at the 2018 Canadian Screen Awards. Liu's first major role was on the critically acclaimed OMNI crime drama Blood and Water, the first trilingual series (English, Mandarin, and Cantonese) produced by Canadian television, for which he received nominations at the ACTRA Awards and Canadian Screen Awards. Aside from his performance on screen, Liu participated in the writing room for the series by contributing in the show's second season as a story editor and as the main writer for one episode. He most recently completed production on the adventure feature Arthur the King. Liu also stars in Lissette Feliciano's Women Is Losers, which will premiere at the 2021 SXSW Film Festival. His other film and television credits include ABC's Fresh Off the Boat, Comedy Central's Awkwafina Is Nora from Queens, NBC's Taken, and Amazon's The Expanse. Moderated by Yul Kwon. Visit g.co/talksatgoogle/SimuLiu to watch the video of this event.
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