As the academic semester is coming to an end it is time for many of us students to graduate from LiU. Indeed, a wonderful accomplishment and as much as we would love to keep you here in Sweden, one day there might be a time when you feel like spreading your wings and flying away. In this episode, we will walk you through the process of leaving Sweden and point out important bureaucratic steps to take. Grab a coffee and come along for an information-packed episode. Host: Julia Berger Guest: Therese Lindkvist, Senior Coordinator at The International Office
Here is a new mix that was aired two weekends ago with the fam on @ghettohouseradio featuring a collective of house, edm, & some pop/dance/mainstream remixes/bootlegs. I hope you enjoy!1. Move It - Valentino Khan & Dillon Francis 2. Ready Or Not - Smack & Swanky Tunes Feat. Ayah Marar 3. Blow - Los Padres and Jay Mac RMX - Jackson Wang4. Ringtone Drop - Liu5. My Love (Glass Animals Remix) - Florence + The Machine6. Put The Sauce On It - Duck Sauce, A-Trak & Armand Van Helden7. First Class - Mark Anthony Run Edit - Jack Harlow Vs Becky Hill & Galantis8. On The Low - Wax Motif & Longstoryshort 9. Words - Alesso & Zara Larsson10. Heaven Takes You Home - Swedish House Mafia Feat. Connie ConstanceDownload the full show that also features Kaskade, Sofi Tukker, and Vinny Vibe here https://tinyurl.com/5yjpwuau. Also, make sure to look me up in iTunes to get my mixes automatically and visit my webpage at www.djpeetiv.com.
Diets high in fiber associated with less antibiotic resistance in gut bacteria United States Department of Agriculture, May 10, 2022 Healthy adults who eat a diverse diet with at least 8-10 grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts, according to a study published by Agricultural Research Service scientists and their colleagues in mBio. Microbes that have resistance to various commonly used antibiotics such as tetracycline and aminoglycoside are a significant source of risk for people worldwide, with the widely held expectation that the problem of antimicrobial resistance (AMR)—the term that refers to bacteria, viruses, and fungi that are resistant to antibiotics—is likely to worsen throughout the coming decades. In this study, the researchers were looking for specific associations of the levels of antibiotic resistance genes in the microbes of the human gut with both fiber and animal protein in adult diets. The researchers found regularly eating a diet with higher levels of fiber and lower levels of protein, especially from beef and pork, was significantly correlated with lower levels of antimicrobial resistance genes (ARG) among their gut microbes. Those with the lowest levels of ARG in their gut microbiomes also had a greater abundance of strict anaerobic microbes, which are bacteria that do not thrive when oxygen is present and are a hallmark of a healthy gut with low inflammation. Bacterial species in the family Clostridiaceae were the most numerous anaerobes found. The strongest evidence was for the association of higher amounts of soluble fiber in the diet with lower levels of ARGs. Soluble fiber, as its name suggests, dissolves in water and is the main type of fiber found in grains like barley and oats; legumes like beans, lentils and peas, seeds (like chia seeds) and nuts; and some fruits and vegetables like carrots, berries, artichokes, broccoli and winter squash. Probiotics stop menopause-like bone loss in mice Emory and Georgia State universities, May 6, 2022 Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers at Emory University School of Medicine and Georgia State University have shown The findings suggest that probiotic bacteria may have potential as an inexpensive treatment for post-menopausal osteoporosis. However, clinical evidence that probiotics can have a lasting effect on the mix of bacteria in the body is limited. Emory and Georgia State researchers found that in mice, the loss of estrogen increases gut permeability, which allows bacterial products to activate immune cells in the intestine. In turn, immune cells release signals that break down bone. Probiotics both tighten up the permeability of the gut and dampen inflammatory signals that drive the immune cells, the team found. Researchers led by Pacifici treated female mice twice a week with Lactobacillus rhamnosus GG (LGG), a type of bacteria found in some yogurts, or with a commercially available mix of eight strains of bacteria known as VSL#3. Good nutrition positively affects social development, research shows University of Pennsylvania, May 6, 2022 Proper nutrition during childhood can positively affect a child's social behaviors and development. It's a unique take on a field that often focuses on how poor diet negatively influences early childhood development. For this study, the scientists analyzed a sample of 1,795 3-year-old children from Mauritius, an island off the eastern coast of Africa with a population of about 1.3 million people. They focused on four aspects of physical health related to nutrition and four indicators of social development. Physical health factors included anemia expressed by low hemoglobin levels, reflecting iron deficiency; angular stomatitis revealed by cracked lips and a lack of vitamin B2 and niacin; and insufficient protein intake indicated by thin or sparse hair and hair discoloration. The researchers considered a child with just one of the quartet as “suffering from nutritional deficits.” However, children with more malnutrition indicators showed more impaired social behavior. Social interactions studied included friendliness, extent of verbalization, active social play and exploratory behavior. Examining the relationship between these components after the fact, they teased out a neurocognitive link between nutrition and comprehensive social behavior. It's a connection undiscovered to this point. “The bigger message is give children good nutrition early on,” Liu said. “Not only will it enhance cognitive function but, importantly, promote good social behavior,” which is essential to brain development and intelligence. “In the same study,” Raine said, “we've shown that children with positive social behavior, eight years later, they have higher IQs.” Diabetes almost doubles risk of death from COVID University of Aberdeen, May 10, 2022 People with diabetes were almost twice as likely to die with COVID and almost three times as likely to be critically or severely ill compared to those without diabetes. However, the study conducted by researchers from the University of Aberdeen, which reviewed data from hundreds of thousands of people from all over the world, also found that good management of the condition can mitigate against the risks. Specifically, the collaboration with King's College, London, found that while diabetes presents a significant risk of severe illness and death with COVID, good control of blood sugar in these patients can significantly reduce this risk. The researchers reviewed findings from 158 studies that included more that 270,000 participants from all over the world to determine how COVID affects people living with diabetes. Eating nuts linked to lower risk of colon cancer Seoul National University College of Medicine (Korea), May 6, 2022 Eating nuts has been linked to a number of health benefits, such as a reduced risk of obesity, diabetes and heart disease. Now, new findings from South Korea suggest that a nut-rich diet may also reduce a person's risk of colon cancer. The researchers found a reduction in this risk for both men and women. Eating a serving of nuts three or more times a week appeared to have a big effect on risk. In the study, a serving of nuts was considered to be 15 grams (0.5 ounces). That's a smaller amount than what's considered a serving in the United States (A serving in the U.S. is 28 g, or 1 oz.) Although the researchers included many types of nuts in their analysis, peanuts were the most widely consumed nuts among people in the study. This may be due to the availability of peanuts in South Korea, the researchers said. The researchers found that men who reported eating three or more servings of nuts a week had a 69 percent lower risk of colon cancer than those who reported eating no nuts. Women who ate three or more servings had an 81 percent lower risk than those who ate no nuts, according to the study. Nicotinamide riboside repairs features of Alzheimer's disease NIH's National Institute on Aging, May 6, 2022 Researchers have found that an NAD+ precursor helped mice with features of Alzheimer's disease perform better on learning and memory tests… The brain's usual DNA repair activity is impaired in Alzheimer's disease, leading to inflammation and dysfunction. A compound that the brain needs to regulate DNA repair and other key signalling pathways is known as nicotinamide adenine dinucleotide (NAD+). Because NAD+ declines with age, scientists have wondered whether boosting the level of NAD+ could help ageing brain cells (neurons) to function better. One way to increase the cellular level is by giving an NAD+ precursor compound, such as nicotinamide riboside (NR). NR is a form of vitamin B3. The team found that the NR-treated mice had less DNA damage, lower levels of neuron damage and death, increased production of new neurons, and lower brain inflammation than control mice. Mice who received NR had reduced tau in their brains, too, but amyloid-beta levels were unchanged. The NR-treated mice performed better than control mice on many learning and memory tests, such as a water maze. In addition, NR-treated mice had better muscle strength and endurance than controls. The research team also tested human cells from people with and without Alzheimer's disease. As in the mouse studies, NR decreased DNA damage in the cells from people with Alzheimer's. Videos: 1. Sensational Charge Against Global Pharma Lobby, Government Hints At Vax Lobby Role In W.H.O Report (4:55) 2. ‘Zelensky is a puppet'; Col. Douglas Macgregor upsets Fox host. (2:18) 3. The Clinton & Gates Foundation were brokers for Big Pharma (4:43)
A demanda turística reprimida durante mais de dois anos reaparece com tudo nas ruas de Paris. A melhora nos números da pandemia de coronavírus, a flexibilização das condições de viagem e, de quebra, a volta dos dias ensolarados têm levado a capital francesa a reviver os áureos tempos em que era uma das cidades mais visitadas do mundo, antes da chegada brutal do coronavírus. Nos pontos turísticos, línguas de todos os países voltaram a ser ouvidas: americanos, britânicos, alemães, latinos e até alguns asiáticos, ainda reticentes à retomada das viagens internacionais. Ça y est: os operadores de turismo festejam o grande retorno da clientela estrangeira à cidade. "Eles estão de volta, de fato, e acho que daqui a 15 dias vai ser ainda melhor, porque o tempo estará ainda mais bonito em Paris. É maravilhoso”, comprova o garçom Cyril, em um café na esquina com a Torre Eiffel. "Estamos vendo muita gente da Europa, mas também da América Latina: Porto Rico, México, Panamá. Muito mesmo. Tem também americanos, mas um pouco menos que o normal." Pela primeira vez desde o início de 2020, a taxa de ocupação dos hotéis na cidade chega a 80%, conforme a União das Atividades e Indústrias da Hotelaria, e ultrapassou 90% no fim de semana de Páscoa. Nesta data, 22 mil pessoas visitaram a torre Eiffel por dia, quase a lotação máxima do monumento, enquanto que os ingressos para o Louvre precisam ser reservados com 48h de antecedência para um sábado, domingo ou feriado. O número de voos vindos da Espanha já supera o registrado em 2019, enquanto os da Itália e Estados Unidos estão próximos de atingir os índices pré-pandêmicos, segundo o escritório parisiense de turismo. A Federação Nacional de Aviação, por sua vez, antecipa para este verão a retomada de 100% dos voos de médias distâncias e 85% dos longos trajetos. Viagem adiada O casal de mexicanos Rodrigo Flores e Guadalupe Romero comemora finalmente poder realizar a viagem com que sonhava. "Fazia tempo que queríamos viajar para esta parte do mundo e por causa da pandemia, tínhamos adiado. Mas agora, tivemos a oportunidade”, afirma ele. "Estou muito emocionada, na verdade, porque tudo isso é novo para a gente. Estamos impressionados com tanta beleza que tem neste lugar, que é magnífico”, diz a mexicana. "E tem muita gente, vimos pessoas do Marrocos, da Colômbia, dos mais diferentes lugares”, indica Guadalupe. No rio Sena, os barcos turísticos passam o dia e a noite lotados, como nos velhos tempos, celebra Badis, gerente de bilheteria do Vedettes de Paris, uma das empresas que oferece passeios nas embarcações. "Temos realmente a impressão de que a pandemia ficou para trás e que as pessoas estão de volta. O fim de semana de Páscoa foi um verdadeiro sucesso e, desde então, só continuou. Estamos muito contentes”, indica o gerente. "Alguns clientes ainda usam máscaras e continuamos a oferecer gel nos barcos, mas a maioria das pessoas está sem máscara. Elas estão felizes, é como uma liberação”, constata. Economias durante a pandemia Essa felicidade se confirma em despesas. "Tenho a impressão que os turistas estão com dinheiro para gastar. Acho que a pandemia os fez economizar, então agora eles se soltaram”, observa o garçom Cyril. Da mesma forma, a vendedora Liu, de uma loja de souvernirs, percebe a disposição dos turistas para gastar sem contar. “Durante a pandemia, estávamos fechados, mas agora a situação está boa e voltamos a abrir. Tem muitos turistas que vêm na França, então para a gente eles nos proporcionam um grande retorno”, festeja. Ainda assim, os turistas asiáticos, raros na multidão, fazem falta. Até 2019, os chineses eram os estrangeiros que mais movimentavam o turismo francês, responsáveis por um total de € 3,5 bilhões.
Plus, Beijing's race to contain Covid-19; three Chinese nationals killed in apparent suicide attack in Pakistan; and JD.com's founder is sued by rape accuser. Are you a big fan of our shows? Then please give our podcast account, China Business Insider, a 5-star rating on Spotify, Apple, or wherever you listen to podcasts!
In this episode, Coach Greg Raymond and Ted Baker talk about welcoming the 1972 national championship team back to campus, the win over LIU and look ahead to the Senior Day game against Mount St. Mary's. The Hobart Lacrosse Podcast is recorded monthly during the offseason and once a week during the season. The podcast is available on HWSAthletics.com, Amazon Music, Google Podcasts and Apple Podcasts. To help support Hobart Lacrosse, please consider joining the Statesmen Athletic Association. Find Hobart Lacrosse on Twitter: @HobartLacrosse; Facebook: facebook.com/HobartStatesmen; and Instagram: @HobartLacrosse.
Outdoor athlete and Outside contributing editor Gloria Liu very much wanted to be one those people with the confidence and carefree spirit to occasionally hike, bike, or ski in the nude. Unfortunately, the decade-old memory of an uncomfortable event at a backcountry hot spring kept her clinging to her knickers. So, like any good competitor, Liu underwent a three-step training plan designed to get her comfortable playing in her natural state while in the woods—not to mention grant her all the scientifically proven benefits of recreating in the buff. This episode was brought to you by Aruba, an island in the Caribbean that offers so much more than a vacation. Learn more about what awaits you at this very special destination at aruba.com.
Comeback, Comeback. In episode 42 of the Hobart Lacrosse podcast, Coach Greg Raymond and Ted Baker talk about, not one, but two comebacks. They breakdown the 12-11 win at Merrimack that included rallying from a 4-0 first quarter deficit. They also look ahead to the Northeast Conference showdown against LIU on Boswell Field, which includes the comeback (reunion) of the 1972 Hobart Lacrosse team that won the College's first national championship. The Hobart Lacrosse Podcast is recorded monthly during the offseason and once a week during the season. The podcast is available on HWSAthletics.com, Amazon Music, Google Podcasts and Apple Podcasts. To help support Hobart Lacrosse, please consider joining the Statesmen Athletic Association: www.hws.edu/statesmen. Find Hobart Lacrosse on Twitter: @HobartLacrosse; Facebook: facebook.com/HobartStatesmen; and Instagram: @HobartLacrosse.
In this episode we explore the mysterious and complex character of Lin Biao, and his even more mysterious demise. We ask how he rose to prominence so quickly after being a largely background figure in the party for so many years, and what effect his vice-chairmanship and sudden death had on the Cultural Revolution.*I accidentally say Liu instead of Lin at around the 22:30 minute mark*00:00 Introdution05:02 Early career in the CCP13:05 Lin Biao in the Cultural Revolution19:58 Lin's position challenged?27:51 The 'conspiracy'36:31 Evaluating the coup theory39:10 The impact of Lin's death
Episode 37: In this episode, host Angie Gust talks about the benefits of Indian gooseberry or amla. It is one of the most important medicinal plants in the Indian traditional medicine of Ayurveda. It helps with many health problems, including heart disease and endothelial dysfunction. When the endothelium is dysfunctional, it causes arterial stiffening which can affect lipid levels and also blood glucose, platelet function, and blood pressure. Turning to the environment, as if it were not already critical that we focus on clean energy, it is even more critical now. Greta Thunberg's Fridays for Future organization says, “Political leaders can take the side of people or of money, greed and the fossil fuel industry. We call on global leaders to stop financing Putin's whims, and end the import of oil, coal, and gas from Russia. We also call for the end of the Nord Stream 2 gas pipeline in Germany — once and for all.” References Adler, B. Mar 1, 2022. Greta Thunberg's climate activist group to launch protests against Russian invasion of Ukraine. https://news.yahoo.com/greta-thunbergs-climate-activist-group-to-launch-protests-over-russian-invasion-of-ukraine-204257333.html Al Jazeera Mar 4. 2022. Moscow's 'lone climate protester' https://www.aljazeera.com/features/2022/3/4/qa-with-moscows-protester-from-climate-change-to-ukraine-war Baliga MS, Dsouza JJ. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev. 2011 May;20(3):225-39. doi: 10.1097/CEJ.0b013e32834473f4. PMID: 21317655. Bartoli, L. Mar 25, 2022. Fridays For Future Is Back: The March 25 Protests. Impakter. https://impakter.com/fridays-for-future-is-back-the-march-25th-protests/ Harrod, M. Mar 2014. Enhance endothelial function and reduce arterial stiffness. https://www.lifeextension.com/magazine/2014/3/enhance-endothelial-function-and-reduce-arterial-stiffness IEA. Mar 8, 2022. Global CO2 emissions rebounded to their highest level in history in 2021. https://www.iea.org/news/global-co2-emissions-rebounded-to-their-highest-level-in-history-in-2021 Liu, Z., Deng, Z., Davis, S.J. et al. Monitoring global carbon emissions in 2021. Nat Rev Earth Environ (2022). https://doi.org/10.1038/s43017-022-00285-w Robinson, B. Mar 17, 2022. Oregon Is Turning Sewage into an Endless Supply of Green Energy. https://reasonstobecheerful.world/oregon-water-treatment-methane-green-energy/ Simon, M Mar 16, 2022. Why You (and the Planet) Really Need a Heat Pump. https://www.wired.com/story/why-you-the-planet-need-heat-pump/
Seguimos recordando a la eximia soprano pesaresa y resumiendo sus opiniones sobre canto y cantantes. Tras el pórtico del aria Un bel di vedremo de Madama Butterfly, pasamos a otra ópera pucciniana, Tosca, en la que fue grande, y la escuchamos junto a Mario del Monaco en un fragmento del dúo del primer acto. Nos vamos a Verdi de inmediato y la seguimos en la parte final del dúo del primer acto de Otello en unión del histórico tenor Francesco Merli. Al parecer fue la primera grabación de la diva (en vivo, 945). A continuación, nos canta el final del Sauce y el Ave María de la misma ópera. Volvemos a Puccini para una diamantina interpretación de Si, mi chiamano Mimi de La bohème. Del mismo compositor la gentil In quelle trine morbidi de Manon Lescaut y la maravillosa aria de Liu, Signore escolta de Turandot. Rematamos con la extraordinaria interpretación de La mamma morta de Andrea Chenier de Giordano en grabación de La Scala con De Sabata de 1951. Escuchar audio
Track list:1 - Lick It (Big J ‘BAM BAM' Edit) - Valentino Khan vs Merk & Kremont2 - I Like It (Smassh 2022 Edit) - Cardi B vs Mark & Kremont & Too Many Zooz)3 - Milkshake (SQUARED Club Edit) - LittGloss4 - We Want Some P#ssy (Audiorokk Baby Edit) - 2 Live Crew5 - Edamame (DJ Beatzilla x Boss Nova ‘Stimulate' Edit) - BBNO$ & Rich Brian x Ship Wrek6 - Have Mercy (Greg Lopez Remix) - Chloe7 - Boasty (Lewis Remix) - Wiley feat Sean Paul, Stefflon Don & Idris Elba8 - Sicko Mode (Rivas ‘ The Night' 2021 Edit) - Travis Scott feat Drake vs NuBass & MPH9 - Rattle (Beatbreaker Edit) - Bingo Players vs BROHUG10 - Deep Down Low (Oing 2021 Remix) - Valentino Khan11 - Click - Tujamo12 - The Function - Yellow Claw, EURO TRA$H13 - Touch it x Freak Show (Danny Diggz Then & Now Bootleg) - Busta Rhymes x Daft Punk x Pirate Snake x Gangbang14 - In Da Getto (Lorenzo Remix) - J Balvin & Skrillex 15 - Bouncybob (Kid Cut Up Hype Edit) - Martin Garrix16 - We Are Your Friends (Fashen ‘Ring the Alarm' Edit) - Justice vs DJ Snake, Malaa & Habstrakt17 - Shake That Ass Bitch (DJ Smerk Be Free Edit) - Splack Pack18 - Go Insane (DJ Nasa ‘Guaracha' Edit) - Drake vs DJ Krlitos19 - Up (DJ Rem ‘Just Feels Tight' Edit) - Cardi B vs FISHER20 - Shots (SQUARED ‘Jump Around' Edit) - Lil Jon vs Cheyenne Giles21 - Agua Freaks (Netto Leon Edit) - Timmy Trumpet22 - Money - Tiesto & Killfake23 - IDFWU (Rivas ‘Be Free' 2021 Edit) - Big Sean vs Smack, Vinnie & John Balaya)24 - Pump Da Club (JD Live Tech House Bootleg) - 50 Cent vs Dom Dolla25 - The Next Episode (HMC 2021 Edit) - Dr Dre feat Nate Dogg vs DMNDS, Fallen Roses & Lujavo vs Liu
Over the last couple of years, it has become increasingly clear that periodontal disease dramatically increases the risk of peri-implantitis, implant failures, and numerous overall health conditions. The mouth cannot be separated from the rest of the body — oral health impacts overall health. Despite that growing awareness, the prevalence of periodontal disease amongst the general populace doesn't seem to be shifting. Dr. Spring Liu is the senior physician in the periodontology and peri-implant diseases division at the University of Zurich. We recently hosted Dr. Liu on our Zircon Medical Podcast to discuss periodontology in the practical and academic context. Support the show (https://www.mypatent.com/blog/zircon-medical-magazine-1)
The relationship between Putin and Xi is a "marriage of convenience," journalist Melinda Liu tells Ian Bremmer on the GZERO World podcast. Russia's war in Ukraine has put China in an awkward spot: they condemn the invasion, but not the invader. Liu, who has been Newsweek's Beijing bureau chief for decades, believes that Xi is likely as isolated and surrounded by sycophants as Putin, which makes predicting what he'll do next very hard. Chinese coverage of the war hasn't been consistent, and neither is China's historical relationships with Ukraine and Russia. She also explains why Xi's biggest problem right now is not Putin, but rather China's zero-COVID policy, which now has 26 million people under lockdown on Shanghai. China is facing a challenge they never saw coming — and that "hits right to the soul."
All good things must come to an end. In this last episode, we inform you that this podcast has reached its final destination. Instead, subscribe to our other podcast Fika with us, where you will hear more about international studies at LiU. You can find Fika with us at Apple Podcasts, Spotify, Google Podcasts or wherever you find podcasts. Thank you and see you there! -- More podcasts from Linkoping University: https://liu.se/en/podcast
Today's episode is all about boosting progesterone production, with a special focus on Seed Cycling. Nora Pope, FCP is a retired Naturopathic Doctor and Creighton Model FertilityCare Practitioner with a private practice in Toronto from 2002-19. She is a highly sought-after public speaker and since 2003, Nora Pope has educated physicians, midwives, pharmacists, and health experts on the scientific use of natural medicines. Dr. Jessica Liu ND is a Naturopathic Doctor, with over 16 years of expertise and clinical excellence in the field of fertility, women's health and pregnancy care. With an extensive background in natural reproductive medicine, Dr. Liu has helped hundreds of families conceive healthy babies, both naturally and with assisted reproductive techniques such as IUI or IVF. Her program, “Creating Vibrant Fertility” has a particular focus in supporting women to move through the emotional trauma of sub-fertility and pregnancy loss in order to awaken their optimal fertility potential. Together Nora and Dr. Liu have created the Fertility CE program, a continuing education program for women's health professionals. Today's episode is sponsored by the Fertility Awareness Mastery LIVE 10 week group coaching program! We start on May 10th! Will you be joining us? Click here to register now! Today's episode is sponsored by the Fertility Awareness Mastery Online Self-Study Course. The most in-depth and comprehensive online fertility awareness self-study program available. Click here to join now! Topics discussed in today's episode: How infections are related to miscarriage's What should you look for if you think you have an infection How to diagnosis your infection Why cervical mucus is important to monitor while your cycle charting How antibiotics effect your cycle and a pregnancy The importance of progesterone to a healthy cycle and pregnancy Connect with Nora: You can connect with Nora on Facebook, Twitter, Instagram and on her website. Connect with Dr. Jessica Liu: You can connect with Nora on Facebook, Instagram and on her website. Resources mentioned: Conceiving with Fertility Awareness Program The Fifth Vital Sign: Master Your Cycles & Optimize Your Fertility (Book) | Lisa Hendrickson-Jack Fertility Awareness Mastery Charting Workbook Fertility Awareness Mastery Online Self-Study Program Related podcasts & blog posts: [FAMM Practitioner Series] FFP 393 | PMS & Low Progesterone | Preconception Planning | Nora DeBora FFP 383 | Boosting Low Progesterone | Short Luteal Phase | PMS | Lisa | Fertility Friday FFP 233 | Progesterone and the Importance of Regular Ovulation | Dr. Jerilynn Prior FFP 185 | Low Progesterone | Short Luteal Phase | Premenstrual Spotting | Lisa | Fertility Friday FFP 144 | Seed Cycling & Hormone Balance | Supporting Your Menstrual Cycle Naturally | Dr. Nicole Sandilands Join the community! Follow Fertility Friday on Instagram! Subscribe to the Fertility Friday Podcast in Apple Podcasts! Music Credit: Intro/Outro music Produced by J-Gantic A Special Thank You to Our Show Sponsors:https://traffic.libsyn.com/fertilityfriday/FFP_Ep_409_mix1.mp3 Fertility Awareness Mastery Mentorship Program (FAMM) This episode is sponsored by FAMM! Are you a women's health practitioner looking for a solid way to incorporate comprehensive fertility awareness chart analysis into your practice? If yes, FAMM is the program you've been waiting for. Click here to apply now! Fertility Friday | Fertility Awareness Programs This episode is sponsored by my Fertility Awareness Programs! Master Fertility Awareness and take a deep dive into your cycles and how they relate to your overall health! Click here to apply now!
Menininkės Emilijos Škarnulytės debiutinis filmas „Kapinynas“ (ang. „Burial“) pateko į kino festivalio „Visions Du Reel“ konkursinę programą „Burning Lights“. Pirmasis ilgametražis jos filmas yra bendras Lietuvos kino kompanijos „Just a moment“ ir Norvegijos kino kompanijos MER FILM projektas. Filmas veda žiūrovus į vietas, kur kitaip patekti neįmanoma. Pokalbis apie jį – su E. Škarnulyte.Briuselio operos teatro „La Monnaie“ repertuare kitą sezoną žiūrovai galės išvysti ne vieną rusišką operą. Teatro vadovas Peter de Caluwe teigia, kad nekeisti kito sezono repertuaro ir jame palikti tris rusų kompozitorių operas nuspręsta, nes, anot jo, menas turi vienyti ir jungti. Plačiau apie tai – Odetos Vasiliauskaitės pokalbyje su vadovu. Situacija komentuoja ir muzikologė Jūratė Katinaitė.Tęsiasi Metų knygos rinkimai. Šiandien pristatome Natalijos Arlauskaitės ir Linos Kaminskaitės sudarytą knygą „Fokuse: moterys Lietuvos kine“, kurią išleido leidykla „Lapas“ ir kuri įtraukta į 2021 m. publicistikos ir dokumentikos knygų penketuką. Ši knyga pirmą kartą lietuviško kino kontekste lyties problematiką gvildena iš trijų skirtingų perspektyvų. Apie tai kolegė Austėja Kuskienė kalbėjosi su knygos sudarytojomis Natalija Arlauskaite ir Lina Kaminskaite.Klasikinės muzikos naujienų apžvalgoje: „Grammy“ apdovanoti klasikinės muzikos atlikėjai ir kūrėjai, „Deutsche Grammophon“ kontraktas su pernai metų F. Chopino konkurso laimėtoju Bruce'u Liu, pasikeitusi soprano Anos Netrebko pozicija dėl karo Ukrainoje ir Berlyne įgyvendinamas projektas - metro stotyse skambanti klasikinė muzika.Rubrikoje „Be kaukių“ vieši Lietuvos policijos vyriausiasis kapelionas, Švč. Mergelės Marijos Ramintojos bažnyčios kapelionas, knygų autorius kunigas Algirdas Toliatas.Ved. Gerūta Griniūtė ir Odeta Vasiliauskaitė
Kelsunn Communications brings you this 5th Episode of a 6-Part Series feat. Dr. Lois Stein, DSW. Dr. Stein received her BS degree in Community Service Education from Cornell University and her MSW and DSW in Social Welfare from Adelphi University. Her social work career began as a medical social worker and expanded over 40 years to include mental health, drug and alcohol and special needs counseling. She works with children and adults, in a safe and stigma-free setting, focusing on a variety of issues such as anxiety, addictions, coping skills, depression, family conflicts, life transitions, parenting, relationships, identity, school issues, self-esteem, stress, and mood disorders. Dr. Stein incorporates a multi-modalities approach to treatment. In addition to her extensive direct practice with children, adults and families, Dr. Stein served as the Assistant Dean of Academic Services and the Director of the MSW Program at the Adelphi University School of Social Work in both the undergraduate and graduate programs. She also served as the Director of the Inaugural BSW & MSW Programs at Long Island University (LIU) in Brentwood, NY. Dr. Stein created an innovative program at LIU whereby she introduced H.S. Students to the Social Work profession. She arrange for the students to get credit for the classes and those credits were accepted at several area colleges and universities in their Human Services and Social Work Programs. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/kelsunn-on-the-air/support
Francesco Colona is currently doing his postdoc research at LiU. Although he did have some experience from Sweden before, some things still took him by surprise. Find out what in this episode! Guest: Francesco Colona, Postdoc, Department of Thematic Studies Host: Priya Eklund, International Coordinator, LiU Editing: Per Wistbo Nibell
Soutenir et s'abonner à Neurosapiens ♥️La musique a un pouvoir dingue sur notre humeur, notre journée, notre concentration… mais quel est ce pouvoir précisément ? Quel est réellement l'impact et, on peut le dire, les bienfaits d'écouter de la musique sur notre cerveau ? Quel est le pouvoir de la musique sur votre outil le plus puissant ? Réponse dans cet épisode ! Production, animation, réalisation et illustration : Anaïs RouxInstagram : https://firstname.lastname@example.orgMusique d'intro KEEP ON GOINGMusique proposée par La Musique LibreJoakim Karud - Keep On Going : https://youtu.be/lOfg0jRqaA8Joakim Karud : https://soundcloud.com/joakimkarudSources A. R. Harvey, Links between the neurobiology of oxytocin and human musicality, Frontiers in Human Neuroscience, 2020.A. Habibi et al., Childhood music training induces change in micro and macroscopic brain structure : Results from a longitudinal study, Cerebral Cortex, 2018.Mehta, R., Zhu, R., & Cheema, A. (2012). Is noise always bad? Exploring the effects of ambient noise on creative cognition. Journal of Consumer Research, 39(4), 784-799.méthodeRitter SM, Ferguson S. Happy creativity: Listening to happy music facilitates divergent thinking. PLoS One. 2017 Sep 6;12(9):e0182210. doi: 10.1371/journal.pone.0182210. PMID: 28877176; PMCID: PMC5587106.Salimpoor VN, Benovoy M, Larcher K, Dagher A, Zatorre RJ. Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat Neurosci. 2011 Feb;14(2):257-62. doi: 10.1038/nn.2726. Epub 2011 Jan 9. PMID: 21217764.LIU, L., & KAGER, R. (2017). Perception of tones by bilingual infants learning non-tone languages. Bilingualism: Language and Cognition, 20(3), 561-575. doi:10.1017/S1366728916000183Liu, L., Kager, R. Enhanced music sensitivity in 9-month-old bilingual infants. Cogn Process 18, 55–65 (2017). https://doi.org/10.1007/s10339-016-0780-7Zatorre RJ, Salimpoor VN. From perception to pleasure: music and its neural substrates. Proc Natl Acad Sci U S A. 2013 Jun 18;110 Suppl 2(Suppl 2):10430-7. doi: 10.1073/pnas.1301228110. Epub 2013 Jun 10. PMID: 23754373; PMCID: PMC3690607. Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out. Become a member at https://plus.acast.com/s/neurosapiens.
Arise Africa, Roar China: Black and Chinese Citizens of the World in the Twentieth Century (UNC Press, 2021) explores the close relationships between three of the most famous twentieth-century African Americans, W. E. B. Du Bois, Paul Robeson, and Langston Hughes, and their little-known Chinese allies during World War II and the Cold War--journalist, musician, and Christian activist Liu Liangmo, and Sino-Caribbean dancer-choreographer Sylvia Si-lan Chen. Charting a new path in the study of Sino-American relations, Gao Yunxiang foregrounds African Americans, combining the study of Black internationalism and the experiences of Chinese Americans with a transpacific narrative and an understanding of the global remaking of China's modern popular culture and politics. Gao reveals earlier and more widespread interactions between Chinese and African American leftists than accounts of the familiar alliance between the Black radicals and the Maoist Chinese would have us believe. The book's multilingual approach draws from massive yet rarely used archival streams in China and in Chinatowns and elsewhere in the United States. These materials allow Gao to retell the well-known stories of Du Bois, Robeson, and Hughes alongside the sagas of Liu and Chen in a work that will transform and redefine Afro-Asia studies. Clara Iwasaki is an assistant professor in the East Asian Studies department at the University of Alberta. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/african-american-studies
Arise Africa, Roar China: Black and Chinese Citizens of the World in the Twentieth Century (UNC Press, 2021) explores the close relationships between three of the most famous twentieth-century African Americans, W. E. B. Du Bois, Paul Robeson, and Langston Hughes, and their little-known Chinese allies during World War II and the Cold War--journalist, musician, and Christian activist Liu Liangmo, and Sino-Caribbean dancer-choreographer Sylvia Si-lan Chen. Charting a new path in the study of Sino-American relations, Gao Yunxiang foregrounds African Americans, combining the study of Black internationalism and the experiences of Chinese Americans with a transpacific narrative and an understanding of the global remaking of China's modern popular culture and politics. Gao reveals earlier and more widespread interactions between Chinese and African American leftists than accounts of the familiar alliance between the Black radicals and the Maoist Chinese would have us believe. The book's multilingual approach draws from massive yet rarely used archival streams in China and in Chinatowns and elsewhere in the United States. These materials allow Gao to retell the well-known stories of Du Bois, Robeson, and Hughes alongside the sagas of Liu and Chen in a work that will transform and redefine Afro-Asia studies. Clara Iwasaki is an assistant professor in the East Asian Studies department at the University of Alberta. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/chinese-studies
Arise Africa, Roar China: Black and Chinese Citizens of the World in the Twentieth Century (UNC Press, 2021) explores the close relationships between three of the most famous twentieth-century African Americans, W. E. B. Du Bois, Paul Robeson, and Langston Hughes, and their little-known Chinese allies during World War II and the Cold War--journalist, musician, and Christian activist Liu Liangmo, and Sino-Caribbean dancer-choreographer Sylvia Si-lan Chen. Charting a new path in the study of Sino-American relations, Gao Yunxiang foregrounds African Americans, combining the study of Black internationalism and the experiences of Chinese Americans with a transpacific narrative and an understanding of the global remaking of China's modern popular culture and politics. Gao reveals earlier and more widespread interactions between Chinese and African American leftists than accounts of the familiar alliance between the Black radicals and the Maoist Chinese would have us believe. The book's multilingual approach draws from massive yet rarely used archival streams in China and in Chinatowns and elsewhere in the United States. These materials allow Gao to retell the well-known stories of Du Bois, Robeson, and Hughes alongside the sagas of Liu and Chen in a work that will transform and redefine Afro-Asia studies. Clara Iwasaki is an assistant professor in the East Asian Studies department at the University of Alberta. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/intellectual-history
This panel will center discussion on the role of the states in our constitutional order—by focusing on states’ highest courts and their role in promoting individual rights and the development of the law. The roundtable will also explore the relationship between the state and federal courts, both historical and contemporary, as well as some of the pivotal moments that produced our modern balance of power. The speakers will also suggest ways that judges in each level of government, along with legislators and lawyers, might help improve the balance of power between states and the federal government.The panelists will discuss the relationship between states and their municipalities. The question of localism was central to the Federalists’ and Anti-Federalists’ debates about the role of government. It was especially significant in respect to the competing interests of agrarian and urban citizens that motivated much ideological conflict in the period. Speakers will discuss how Anti-Federalist preferences for localism and Federalist preferences for nationalization helped produce our modern balance of governmental powers and legal culture. The roundtable will debate whether they see a return to localism soon and, if so, what implications this might have for constitutional governance.Featuring:Moderator: The Honorable Neomi Rao, United States Court of Appeals for the District of Columbia CircuitThe Honorable Goodwin H. Liu, Associate Justice, Supreme Court of CaliforniaThe Honorable Jeffrey S. Sutton, United States Court of Appeals for the Sixth CircuitProf. Julia D. Mahoney, John S. Battle Professor of Law, University of Virginia School of Law
Serving At the Pleasure of the President With Ty Cobb, Bob Bennett and Stefan Passantino With Host Richard Levick of LEVICK: As a preview for a panel for Primerus, a society of nearly 200 of the world's finest independent, boutique law firms in 40 countries, three former counsels to U.S. Presidents joined host Richard Levick of LEVICK to discuss the unique issues associated with these matters. Robert Bennett, Senior Counsel to Bennett LoCicero & Liu and President Clinton's personal lawyer in the Paula Jones case; Ty Cobb, currently handling selected complex litigation matters at Ty Cobb, PLLC and former Assistant to the President of the United States, serving as Special Counsel to President Trump; and Stefan Passantino, former Deputy White House Counsel to President Trump and the Chair of Michael Best's Government Regulations & Public Policy practice where he heads the firm's Political Law practice, engaged in a robust conversation about being counsel to a U.S. president, the challenging issues of executive privilege, the January 6th investigation and more.
The weekly radio show from Alok. 01. Alok & Alan Walker feat. KIDDO - Headlights02. Shouse - Won't Forget03. Alok feat. Au/Ra - Side Effect04. Alok - Deeper05. Flakkë - Body Talk [PREMIÈRE]06. Bhaskar & Breaking Beattz feat. your friend polly - Higher07. Maurice West - Looking For Your Love08. Kasablanca - Synthetic Blues (Matt Fax Remix)09. Ferry Corsten - Punk10. Motorcycle - As The Rush Comes11. Elderbrook x Bob Moses - Inner Light12. Diplo & Miguel - Don't Forget My Love13. Alok & Bhaskar feat. MAGNUS - See You There14. Kx5 feat. Hayla - Escape15. Alesso & Katy Perry - When I'm Gone16. Tiësto & Ava Max - The Motto17. Liu, Hawk & Erjona Sylejmani - Hanging Tree18. Öwnboss & Sevek - Move Your Body19. Sonny Fodera - About You20. Sander Van Doorn - Breakfast In Vegas
Exelless - Slap House Session Vol.1 Дата релиза: 22.03.2022. Направление: Slap House Следите за новостями: promodj.com/exelless Электронной музыкой и диджеингом Алексей занимается уже не первый десяток лет, однако только сейчас появилась возможность реализовать своё хобби как профессиональную деятельность, для чего в конце 2021 он поступает в известную Питерскую школу диджеев «Clubmasters», по максимальному курсу обучения, включающему в себя все необходимые технические навыки и работу над созданием профессионального портфолио. После прохождения обучения и окончания всех работ, Алексей начинает активно двигаться в данном направлении, развивая себя как профессионального Артиста в мире танцевальной музыки. Основная музыкальная направленность Exelless - это различные, коммерчески успешные направления EDM стилей, таких как Future, Slap, Electro и Club House. Его миксы, это гармоничная смесь всей палитры данных стилей, грамотно смешанных в одно целое, заставляющая оставаться неравнодушной любую, даже самую требовательную публику. #SlapHouse #House #ClubHouse #FutureHouse #DJ #Exelless #ClubmastersRecords #Mix #школадиджеев #школаdj #школадиджеинга #статьдиджеем #диджеинг #диджей #dj #курсыдиджеев #обучениедиджеев #обучениеdj #djschool #Traktor #Rekordbox #Serato #VirtualDJ #школаэлектронноймузыки #созданиемузыки #написаниемузыки #звукорежиссура #cubase #flstudio #флстудио #ableton #abletonlive #материнг #mix #mixing #аблетон #аблетонлайв #logic 01. Rolipso - Bugatti Ridin (Extended Mix) 02. John Skyfield, Gktrk & Luxe - Balance (Na Na) (Extended Mix) 03. Charles B, Bayan And Julian, Booty Leak - Bang Bang (Extended Mix) 04. Dino Warriors, Julian Perretta - Ayo Technology (Dimitri Vegas Mix) 05. Moti & Ellipso - Ringtone (With Wilhelmina) (Extended Mix) 06. Moti - No Scrubs (Extended Mix) 07. Liu, Hawk, Erjona Sylejmani - Hanging Tree (Extended Mix) 08. Alan Walker, Imanbek - Sweet Dreams (Malevich Extended Mix) 09. Max Fail, Kanslor, Zero Sugar - Don't Stop The Music (Extended Mix) 10. Lika Morgan - Ready or Not (Extended Mix) 11. Lika Morgan - Girls Like to Have It All (Extended Mix) 12. Natan & Kilian K - Right Now (Extended Mix) 13. Ferry - Heavy Shoulders (Extended Mix) 14. Plastik Funk, Relanium, Deen West - San Francisco (Extended Mix) 15. Steve Void, Koosen - Summer Jam (Extended Mix) 16. Pascal Junior, Hot Pixels - Feel You Closer (Extended Mix) 17. Pascal Junior - Draw The Line (Extended Mix) 18. Wankelmut, Money For Nothing - Beautiful Mind (Extended Mix) 19. Going Deeper, Camilia - Pulled My Gun (Extended Mix) 20. Yves V, Ilkay Sencan, Emie - Not So Bad (Extended Mix) 21. Dallerium, SebDell - Illuminate (Extended) 22. Killteq, D. Hash - Love Me Again (Extended Mix) 23. Curbi, Helen - Feel (Scott Rill Extended Remix) 24. Kilian K, Jannis Block & Relu - Be Alright (Extended Mix) 25. Mike Candys - Lights Go Down (Extended Mix) 26. Sagan Feat. Catali - Therapy (Extended Mix) 27. Going Deeper, Ryan Konline - Taste The Night (Extended Mix) 28. Faulhaber & Mingue - The Snowman (Extended Mix)
Read along to practice your English and to learn the English phrases TO BITE YOUR TONGUE and BITE YOUR TONGUE!In this English lesson, I wanted to help you learn the English phrase to bite your tongue. Now, sometimes you're chewing food and you accidentally bite your tongue, and that doesn't feel very good. It hurts quite a bit. But we use the phrase to bite your tongue to talk about when you try not to say something in a certain situation. Maybe your boss is telling you that you've done something poorly and you want to say something back to your boss. It's probably not a good idea. It's probably a good time to bite your tongue. I had this when I was a kid as well. Once my dad was a little bit annoyed with me about something, and then I said something, but I should not have done that. When I think back, I think, it probably would have been a better idea to bite my tongue than to say something, because it just made my dad a little bit more annoyed.WANT FREE ENGLISH LESSONS? GO TO YOUTUBE AND SEARCH, "BOB THE CANADIAN"If you enjoy these lessons please consider supporting me at: http://www.patreon.com/bobthecanadianThe second phrase I wanted to teach you today is the same phrase, but as a command. You can say to someone, "Bite your tongue," and it basically means that you want them to stop talking. So, if someone is talking to you and they're not being very nice and you want to tell them to shut up. That's kind of a mean thing to say. You could also say, "Bite your tongue," but it's not a nice thing to say to someone. When you say, "Bite your tongue," it's very direct. It's very, it's definitely a command. It's maybe something a parent would say to a child, if they're very, very frustrated or annoyed with their child. They might say, "Bite your tongue," and it's also used a lot when people use bad words, like a parent, if a child said the F-word, for instance, a parent might say, "Hey, bite your tongue. Don't use swear words. That's bad."Anyways, to review, to bite your tongue is simply to stop yourself from talking. I guess, if you actually did bite your tongue a little bit, that does stop you from saying something, doesn't it? And when you tell someone to bite their tongue, or if you say, "Bite your tongue," it means that you want them to shut up. It means that you want them to stop saying whatever they're saying.But hey, let's look at a comment from a previous video. This comment is from Liu. "After spending an afternoon at a social event, I was tuckered out. I'm not good at socializing. It's always hard for me to find topics and to keep the conversation going." And then my reply. "Social events can be exhausting."Now, I've mentioned this before a few times, that as much as I seem like this happy, friendly person here on YouTube, and that you might think that I'm really outgoing and love social events, I'm actually similar to Liu. When I go to a social event, it can be a little bit draining. We learned the English phrase to be tuckered out, which means to be really tired. Sometimes when I go to social events, at the end of it, I'm just really, really tired and exhausted, more like mentally exhausted, if you know what I mean. My favorite kind of event is the event where there's just a few people, not a lot of people just, I don't know, three or four people sitting around a campfire. That is my favorite type of event.Support the show (https://www.patreon.com/bobthecanadian)
China Spying UN Blues, by Matthew Russell Lee InnerCityPress.com 3/19/22 A man was stabbed in Flushing Queens Two day later an arrest and no one says what it means They tell the Press it's just a coincidence But denying the link to the murder makes no sense This is the story of Shujang Wang He spied on Uighurs and to his handlers he sang He was run out of China's Mission to the United Nations One of the World War Two's most failed creations Jim Li before being stabbed tweeted per United We Win Now on the lam is China spy Qiming Lin He tried to make dirt about a man running for the House The UN, asked about its role, is quiet as mouse For Jason Sun, Frank Lui sent a Florida prison guard To hit the Xi Jinping COVID satire work very hard Inner City Press raised the UN in a presser by Peace of EDNY They heard the guard's mother called for bond in Ohio cry The cases are connected and we're gonna keep transcribing While in the UN of Guterres the Chinese GONGOs keep on bribing Guterres at the Genocide Games gave rise to a first book Now the two on the lam we'll be taking a second look Support https://www.patreon.com/MatthewRussellLeeStory: http://www.innercitypress.com/china3ednyuncompliciticp031622.html China Spying In NY Leads to Indictments So Inner City Press Gets EDNY Answer All 3 Bailed As UN Silent By Matthew Russell Lee SDNY / UN GATE, March 16 – The day after the SDNY prosecution of Zhongsan Lui for illegal recruitment in the US was covered by Inner City Press (and the involved UN refused to answer Press questions on it), from EDNY this: "Two complaints were unsealed and one amended complaint was authorized today in federal court in Brooklyn charging five defendants with various crimes related to efforts by the secret police of the People's Republic of China (PRC) to stalk, harass, and spy on Chinese nationals residing in Queens, New York and elsewhere in the United States... Fan “Frank” Liu and Matthew Ziburis were arrested yesterday, while Shujun Wang was arrested this morning. All three arrests occurred in the Eastern District of New York. The defendants' initial appearances are scheduled this afternoon in Brooklyn before United States Magistrate Judge James R. Cho." (Inner City Press will cover that) Just after 3 pm, Breon Peace, United States Attorney for the Eastern District of New York, held a telephone press conference, to his credit, and took four questions. Inner City Press asked about the role of the UN and China's Mission to the UN, noting the NYPD Angwang case and the recent persona non grata removal of a UN staff member for working for Russia. The answer, for now, was that China's intimidation is growing wider. Inner City Press live tweeted the presentments in which all three were bailed, thread here: OK - now in EDNY, presentment of defendant Fan “Frank” Liu, charged with interstate harassment, operating as agent of China without FARA notification, etc Liu's lawyer: I think we have arrived at something close to an agreement on bond. [Lui will be released -- note that NYPD Angwang wasn't, at first - now he's out]. Judge James R. Cho: What's the proposed bail package? AUSA: We are close. AUSA: One million bond with attachment of Mr. Liu's two properties, one in Jericho NY and the other in Florida. Electronic monitoring with a curfew. Cannot to go PRC consultate [UN Mission of China on 35th Street]. US wants $100,000 case. Lui says 25K AUSA: We're stuck at $50,000. The defendant has $3 million in funds related to this case have been transferred into his and his wife's account. He was an agent of the PRC. He's had extensive contacts with the PRC consulate. Lui's lawyer: The US is only alleging payments of $1500 to a private investigator for public record. There's the destruction of a work of art by a "not particularly famous Chinese artist."
“How do we think about building an inclusive product that represents what families look like today, which might be very different than what families looked like 200 years ago. We want voices from all over to help us shape that product.” With 20 years of experience in the technology sector – including stints at eBay, PayPal, and an executive position at Facebook – Deb Liu now leads the high-tech portal where access to 30 billion genealogical records can provide a deeper understanding of one's unique heritage. With 20 million users worldwide, Ancestry is the largest for-profit company of its kind. As the daughter of Chinese immigrants, Liu knows how her company's services can transcend matching names to data. “What we build at Ancestry is not just a tool to share information,” she tells Mike, “but it's really about storytelling and actually building something that hopefully you'll give to your children and your grandchildren someday… It's really the story of all the people who made decisions, just like my parents leaving their home to go to another country. It's those stories that actually make us who we are today.”
This month on Episode 34 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the March 4 and March 18th issues of Circulation Research. This episode also features a conversation with Dr Mireille Ouimet and Sabrina Robichaud from the University of Ottawa Heart Institute to discuss their study, Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis. Article highlights: Pauza, et al. GLP1R in CB Suppress Chemoreflex-Mediated SNA Lim, et al. IL11 in Marfan Syndrome Hohl, et al. Renal Denervation Prevents Atrial Remodeling in CKD Liu, et al. Smooth Muscle Cell YAP Promotes Arterial Stiffness Cindy St. Hilaire: Hi and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our March issues of Circulation Research. I'm also going to speak with Dr Mireille Ouimet and Sabrina Robichaud from the University of Ottawa Heart Institute, and they're with me to discuss their study, Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis. The first article I want to share is titled GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition. The first author is Audrys Pauza, and the corresponding authors are Julian Paton and David Murphy at the University of Bristol. Cindy St. Hilaire: Hypertension and diabetes are risk factors for cardiovascular disease. And yet, for many patients with these two conditions, lowering blood pressure and blood sugar is insufficient for eliminating the risk. The carotid body is a cluster of sensory cells in the carotid artery, and it regulates sympathetic nerve activity. Because hypertension and diabetes are linked to increased sympathetic nerve activation, this group investigated the role of the carotid body in these disease states. They performed a transcriptome analysis of crowded body tissue, from rats with and without spontaneous hypertension. And they found among many differentially-expressed genes that the transcript encoding glucagon-like peptide-1 receptor or GLP1R, was considerably less abundant in hypertensive animals. Cindy St. Hilaire: This was of particular interest because the gut hormone GLP-1 promotes insulin secretion and tends to be suppressed in Type 2 diabetes. Moreover, GLP1R agonists are already used as diabetic treatments. This group showed that treating rat carotid body with GLP1R agonist suppresses sympathetic nerve activation and arterial blood pressure, suggesting that these drugs may provide benefits in more than one way. Perhaps the carotid body could be a novel target for lowering cardiovascular disease risk in metabolic syndrome. Cindy St. Hilaire: The second article I want to share is titled Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan syndrome. The first author is Wei-Wen Lim, and the corresponding author is Stuart Cook and they're from the National Heart Center in Singapore. People with the genetic connective tissue disorder Marfan syndrome, are typically tall and thin with long limbs and are prone to skeletal, eye and cardiovascular problems, including a life-threatening weakening of the aorta. While Marfan syndrome patients commonly take blood pressure-lowering treatments to minimize risk of aortic aneurysm and dissection, there's currently no cure for Marfan syndrome or targeted therapy. Cindy St. Hilaire: The cytokine IL11 is strongly induced in vascular smooth muscle cells upon treatment with the growth factor TGF-beta, which is over activated in Marfan syndrome patients. And TGF-beta is also considered a key feature of the syndrome's molecular pathology. This study found that IL11 is strongly upregulated in the aortas of Marfan syndrome model mouse, and that genetically eliminating IL11 in these animals protected them against aortic dilation, fibrosis, inflammation, elastin degradation and loss of smooth muscle cells. Treating Marfan syndrome mice with anti-IL11 neutralizing antibodies exhibited the same beneficial effects. These results suggest that perhaps inhibiting IL11's activity could be a novel approach for protecting the aortas of Marfan syndrome patients. Cindy St. Hilaire: The next article I want to mention is titled Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in Chronic Kidney Disease. The first authors are, Mathias Hohl, Simina-Ramona Selejan and Jan Wintrich, and the corresponding authors also Mathias Hohl, and they're from Saarland University. People with chronic kidney disease have a two to three fold higher risk than the general population of developing atrial fibrillation, which is a common form of arrhythmia that can be life-threatening. Chronic kidney disease is associated with activation of the sympathetic nervous system, which can be damaging to the heart. Thus, this group examined myocardial tissues from atrial fibrillation patients with and without chronic kidney disease to see how they differ. They found that atrial fibrosis was more pronounced in patients with both conditions than in patients with atrial fibrillation alone, suggesting that chronic kidney disease perhaps exacerbates or even drives arterial remodeling. Cindy St. Hilaire: Sure enough, induction of chronic kidney disease in rats led to greater atrial fibrosis and incidence of atrial fibrillation than seen in the control animals. Renal denervation is a treatment in which the sympathetic nerves are ablated, and it's a medical procedure that's used for treating uncontrolled hypertension, and it has also been shown in animals to reduce atrial fibrillation. Performing renal denervation in the rats with chronic kidney disease reduced atrial fibrosis and atrial fibrillation susceptibility. This study not only shows that chronic kidney disease induces atrial fibrosis and in turn atrial fibrillation, but also suggests that renal denervation may be used in chronic kidney disease patients to break this pathological link and prevent potentially deadly arrhythmias. Cindy St. Hilaire: The last article I want to highlight is titled YAP Targets the TGFβ Pathway to Mediate High-Fat/High-Sucrose Diet-Induced Arterial Stiffness. First author is Yanan Liu and the corresponding author is Ding Ai from Tianjin Medical University. Metabolic syndrome is characterized as a collection of conditions that increase the risk of cardiovascular diseases, such as obesity, hypertension and diabetes. Among the tissue pathologies associated with metabolic syndrome is arterial stiffness, which itself is a predictor of cardiovascular disease incidence and mortality. To specifically investigate how arterial stiffness develops in metabolic syndrome, this group fed mice a high-fat, high-sugar diet, which is known to induce metabolic syndrome and concomitant arterial stiffness. Cindy St. Hilaire: After two weeks on the diet, the animals' aorta has exhibited significant upregulation of TGF-beta signaling, which is a pathway known for its role in tissue fibrosis, and the aorta has also exhibited increased levels of yes-associated protein, or YAP, which has previously been implicated in vascular remodeling, collagen deposition and inflammation. YAP gain and loss of function experiments in transgenic mice revealed that while knockdown of protein in the animals' smooth muscle cells attenuated arterial stiffness, increased expression exacerbated the condition. Cindy St. Hilaire: The team went on to show that YAP interacted with and prevented the activation of PPM-1 B, which is a phosphatase that normally inhibits TGF-beta signaling and thus fibrosis. Together the results suggest that targeting the YAP, PPM-1 B pathway, could be a strategy for reducing arterial stiffness and associated cardiovascular disease risk in metabolic syndrome. Cindy St. Hilaire: Today, Sabrina Robichaud and Dr Mireille Ouimet from University of Ottawa Heart Institute are with me to discuss their study Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis, which is in our March 18 issue of Circulation Research. So thank you both for joining me today. Sabrina Robichaud: Thank you so much for having us. It's a pleasure. Mireille Ouimet: Thank you for having us. Cindy St. Hilaire: Yeah, and congrats on the study. So we know that LDL particles contain cholesterol and fats, and these are the initiating factors in atherosclerosis. And it's also really now appreciated that inflammation in the vessel wall is a secondary consequence to this lipid accumulation. Macrophages are an immune cell that, in the context of the plaque, gobble up this cholesterol to the point that they become laden with lipids and exhibit this foamy appearance, which we now call foam cells. And these foam cells can exhibit atheroprotective properties, one of them called reverse cholesterol transport, and that's really one of the focuses of your paper. So before we dig into what your paper is all about, could you give us a little bit of background about what reverse cholesterol transport is in the context of the atherosclerotic plaque? And maybe introduce how it links to this cellular recycling program, autophagy, which is also a big feature of your study. Mireille Ouimet: Yes, so the reverse cholesterol transport pathway is a pathway that's very highly anti-atherogenic. It's linked to HDL function and the HDL protective effects, in that HDL can serve as a cholesterol acceptor for any excess cholesterol from arterial cells or other cells of the body and return this excess cholesterol to the liver for excretion into the feces. There is also trans-intestinal cholesterol efflux that can help eliminate any excess bodily cholesterol. Mireille Ouimet: So reverse cholesterol transport is a way that we can eliminate excess cholesterol from foam cells in the vascular wall, and that's why we're really interested in the process. But the rate-limiting step of cholesterol efflux out of foam cells in plaques is actually, they have to be mobilized in the form of free cholesterol to be pumped out of the cells through the action of the ATP-binding cassette transporters. And so the rate-limiting step of the process is the hydrolysis of the cholesterol esters and the lipid droplets, because that's where the excess cholesterol is stored in foam cells. Mireille Ouimet: And so for years, people investigated the actions of cytosol like lipases in mobilizing free cholesterol from lipid droplets, although the identity of those lipases are not well-known and in macrophage themselves, but our recent work showed a role for autophagy in the catabolism of lipid droplets. And in fact, in macrophage foam cells, 50% of lipid droplet hydrolysis is attributable to autophagy while the other half is mediated by neutral lipases, which makes it really important to investigate the mechanisms of autophagy-mediated lipid droplet catabolism. Cindy St. Hilaire: That is so interesting. I guess I didn't realize it was that significant a component in that kind of rate-limiting step. That's so cool. So really, a lot of the cholesterol efflux studies, and maybe this is just limited to my knowledge of a lot of these cholesterol efflux studies, but to my knowledge, it's been really focused on the foam cell itself, the macrophage foam cell. However, there's been a lot of recent work that has now implicated vascular smooth muscle cells in this process. So could you share some of the research specific to smooth muscle cells and smooth muscle-derived foam cells that led you to want to investigate the contributions of smooth muscle cell-derived foam cells in cholesterol efflux? Mireille Ouimet: Yeah, so you're right in the sense that macrophages have always been the culprit foam cells in the atherosclerotic plaques but pioneering work from several groups, including Edward Fisher and Gordon Francis, they've shown that the smooth muscle cells can actually acquire a macrophage-like phenotype becoming lipid-loaded and foamy. And there's been work specifically looking at the ABC transporters, and their ability to efflux cholesterol from these vascular smooth muscle cell-derived foam cells, because as they trans-differentiate into macrophage-like cells, they acquire the expression of ABCA1, but this is to a lower extent, as compared to their macrophage counterparts. Mireille Ouimet: And the efflux is defective because there's an impairment in liposomal cholesterol processing of the lipoproteins that's really important to activate a like cell, and the expression of the ABC transporters, so vascular smooth muscle cell-derived foam cells are very poor effluxes. Sabrina Robichaud: There's very few studies that look at the vascular smooth muscle cell foam cells, and the very few that did look at it mostly focused on the ABCA1 transporters, and did show that they were poor effluxes. And as we all know, ABC1 is not the only cholesterol transporters that can transport cholesterol out of cells, there's also ABCG1 which is also one of our major findings in our paper. Cindy St. Hilaire: Can you tell us a little bit about the models you chose in the study and why you picked them? And also maybe a step back in terms of, what are the pros and cons of using mouse models in atherosclerotic studies? Sabrina Robichaud: So we chose to use the GFP-LC3 reporter mouse model because it allows us to track in lifestyle the movement of LC3, which is the main component of the autophagosome which is involved in pathology. So by using this reporter model, we could infer whether or not the cells had high autophagy or low autophagy. And to induce atherosclerosis in these mice, instead of backcrossing them to either an LDLR knockout or an ApoE knockout, we chose to do the adeno-associated virus that encode the gain of function PCSK9 instead to kind of minimize the time for breeding. It did have the effect that we needed in terms of raising plasma cholesterol to induce the atherosclerosis. So that was one of the models that we used in our paper. Mireille Ouimet: There's not very many good mouse models to study autophagy flux in vivo and GFP-LC3 is kind of the main one currently. We're working on developing some other tools to track lipophagy in vivo, but these things take time to put in place. So in the future, we hope to have some better tools to track lipophagy in real-time in vivo. Cindy St. Hilaire: How difficult is it to measure autophagy flux in vivo? I know there's certain part like LC3 or P62, a lot of people use a western blot and it's like, oh, it's high, it must be active, but it's a flux. So it's a little bit more... There's more subtleties to that, dynamic than that. So how difficult is it to really measure this flux in in vivo tissues? Mireille Ouimet: Yes, so now there are more recent mouse models that have been developed more recently to replace kind of the GFP-LC3 is the Rosella LC3. So it has both a red and a green tag, and so two LC3, so when autophagosomes are fused to lysosomes and are degraded, then there's preferential quenching of the GFP first, and then you have the red appearance that predominates so we know that then it's kind of like it a live flux measurements. Because we use the GFP-LC3 mouse, Sabrina treated her cells ex vivo. When we dissected out the aortic arches, digested the cells then we divided those into two components and added bafilomycin so that we can inhibit lysosome acidification to see the changes in the flux. And that's really to get the differences in untreated versus bafilomycin-treated. Mireille Ouimet: When we inhibit the lysosome, then we're sure that it is a functional flux or not. But it's kind of an indirect way of measuring it, and it reads very complex when we're talking about P62 and LC3 degradation with or without lysosome inhibition, but you really need that lysosomal inhibition, to show that if you block the degradation of the autophagosomes that fuse in with a lysosome, then you get an increase in the LC3 and the P62, and that's when you know that the flux is you intact. Mireille Ouimet: Because you could get an increase in LC3, that's just related to a defect in the breakdown of the autophagosome. But in our study, we've used phosphorylated ATG16L1, which is a now better marker of active autophagy. And I would recommend researchers to begin to use that rather than the combination of P62 and LC3 together with or without a lysosome inhibitors such as- Cindy St. Hilaire: Oh, interesting. So let's repeat that, phosphorylated ATG- Mireille Ouimet: 16L1, yes. So there's been an antibody that was developed by a colleague at the University of Ottawa, Dr Ryan Russell, and it's commercially available through cell signaling now, and it really has been a great tool to track active autophagy. Cindy St. Hilaire: That's great. I remember my lab was looking at that at one point, and I was trying to explain the flux as... I don't know if people are going to remember this, but there's this amazing, I Love Lucy skit, where her and Ethel are working on a chocolate factory conveyor belt, and it picks up speed. And because she can't get it all done quick, she starts stuffing them in her mouth. And it's like, if you just took a snapshot of that, you would not know whether it's going too fast, or not functioning properly. And so I equate the flux experiments to that. Which are probably aging myself a lot on so. Cindy St. Hilaire: All right, so sticking to kind of the autophagy angle, what were the differences you found in autophagy in early and late atherosclerotic plaques? Because I know you looked at those two time points, but also, importantly, between the macrophage foam cells and the smooth muscle cell-derived foam cells? Sabrina Robichaud: So surprisingly, there weren't that big of a difference between each time point when we were looking at the individual cell type by themselves. Surprisingly, we did find that the macrophages did have a functional autophagy flux, even at the later stages of atherosclerosis, which was kind of interesting in itself. But when we looked at the vascular smooth muscle cell foam cells, though, that was a whole other story, and we found that these were actually defective at a very early stage and stayed defective up until the very late stage of atherosclerosis. Cindy St. Hilaire: And what is the very early stage like? What's that definition with the smooth muscle cell? Sabrina Robichaud: So we did a six-week time points in terms of our atherosclerosis study, and then a 25-week time point. So there are far apart, which shows like the very early, early stage and what would be considered the most effective autophagy at that point with the necrotic core and everything. So surprisingly, the two phenotype were quite similar at early and both late stages for both cell types, but were functional in the macrophages but dysfunctional in the smooth muscle cells. Cindy St. Hilaire: So you mentioned at one point in the discussion that you observed inconsistent lipid loading of the smooth muscle cells, and you mentioned that a lipase, which is excreted from the foam cells can then be internalized by, I assume kind of neighboring or in the vicinity, smooth muscle cells. And so the question I had it's kind of one of those chicken-and-egg question, and it's, is the smooth muscle cell-derived foam cell an independent process? Does it happen alone or de novo as a function of a smooth muscle-mediated process? Or is it really dependent first on this macrophage foam cell providing this lipid that is efflux that is then internalized by a smooth muscle cell that kind of goes on to become a foam cells. It's kind of a question of like the continuum of an atherosclerotic plaque and what do you think is happening, either based on your data or just kind of a hunch? Mireille Ouimet: That's an excellent question. And there's no doubt that macrophages really drive the initiating events of atherosclerosis. So I don't think that without the macrophage there would ever be a vascular smooth muscle cell, or there would be minimal vascular smooth muscle cell-derived foam cells. Definitely the inconsistencies that we observed in our study, were if we added like aggregated LDL on its own to a primary mouse vascular smooth muscle cell, we would get poor lipid loading and a very low percentage of those cells that would become foamy, relative to treating them with cyclodextrin complex cholesterol, for instance. Mireille Ouimet: So free cholesterol, that's cell permeable, will go into the vascular smooth muscle cell, no problem, and generate the foaminess and then allow that cell to acquire the macrophage-like phenotype. But aggregated LDL on its own in our hands, just gave very poor loading. And when we treated the vascular smooth muscle cells with aggregated LDL along with macrophage-derived condition media, we got some improvements, but it was still kind of inconsistent. But then we thought if we treat the vascular smooth muscle cells with aggregated LDL in the presence of conditioned media from macrophage foam cells that were preloaded with the aggregated LDL, would that promote their foaminess to a greater extent? And it did. Mireille Ouimet: So, there have been studies from Gordon Francis's lab that showed that adding recombinant lysosomal acid lipase to vascular smooth muscle cells that contained aggregated LDL, promoted the lysosomal hydrolysis of the aggregated LDL and to generate the foamy macrophages and allow the lysosomal processing. So we know that that vascular smooth muscle cells take up lysosomal acid lipase, and we know that macrophages undergo lysosome exocytosis and they can secrete lysosome acid lipase and acidify the extracellular milieu. Mireille Ouimet: So work from Fred Maxfield group has shown the presence of these cell surface connected compartments that are acidified, containing macrophage-derived lysosomal acid lipase, that even hydrolyze extra cellularly-aggregated LDL for macrophages. So we're not sure whether there's probably a local production of free cholesterol in the plaque by macrophages, this free cholesterol could be taken up by the vascular smooth muscle cell. And also the vascular smooth muscle cells do express some scavenger receptors, whether the expression of these scavenger receptors like LRP or CD36 even goes up when they've taken up a little bit of the free cholesterol. And then that allows the aggregated LDL to come in and then there would be some lysosomal acid lipase secreted by the macrophage foam cells that would promote the lysosomal processing of this aggregated LDL. All of those are very complex questions that will require some addressing in vivo models. Cindy St. Hilaire: You also mentioned in the paper that studies... There's a handful of them now. Studies have shown that between 30% and 70% of the cells that are staining positively for macrophage markers, meaning they're foam cells, are of the smooth muscle cell lineage. And so I believe people have seen that in mouse plaques with lineage tracing, but they've also used newer techniques to really see this also in human atherosclerotic plaques. So we know it's not just from a mouse, we know that smooth muscle cells can turn into a macrophage-like foam cell, and it's 30% to 70%, which is a huge range. Cindy St. Hilaire: So do we know the factors that dictate whether a specific plaque is going to have more or less smooth muscle cell derived foam cells? And I guess more important to what you found in your paper is, how important would it be to know whether a plaque is on the 30% end or on the 70% end in terms of therapeutic strategies? Sabrina Robichaud: Yeah, most of these studies, the range can be attributed to the different time points at which these studies have been collected early on will be a little bit more macrophage understanding would be at a later time point. Now of course in terms of therapeutics, as we saw in our paper, metformin actually will positively increase cholesterol efflux in the vascular smooth muscle cell foam cells, but not in the macrophages. So obviously, being able to know at which point there's a majority of macrophages versus vascular smooth muscle cells, definitely going to determine which therapeutic we're going to be able to use. Sabrina Robichaud: Ideally, we would be able to find a therapeutic that would work in both foam cell, but from what we've seen, the mechanistic behind the autophagy dysfunction between both cell types are so different, that I'm not entirely sure that that would be possible, we would need some sort of combination therapy. But again, we need to be a little bit more targeted depending on the percentage of the foam cells that are comprising the plaque at that particular moment in time. Cindy St. Hilaire: Yeah, so you mentioned there's a function of time there. If you look earlier, there's more macrophage, if you look later, the percent of smooth muscle cell-derived foam cell increases. Is there a point in a very advanced atherosclerotic plaque where it's just mostly smooth muscle cells? Or do those macrophage foam cells stay, and it's just the increasing number of smooth muscle cell-derived foam cells? Do we know? Mireille Ouimet: This is an excellent question, and I was going to bring up the topic of clonal expansion of the vascular smooth muscle cells. So it's a very heterogeneous population and understanding that might be some of the differences that we see in different studies. It could be the model has one type of a smooth muscle cell that's expanding more than another, what are the factors that govern that? Does one clone take over at the later stages versus the earlier stages? We don't know. Mireille Ouimet: But we were surprised in our studies to see that the macrophages that are present at least on the lumen of the plaques were very active in autophagy. They had the highest staining for the phospho-ATG16L1 in that late stage. So we're not sure if it's newly-recruited macrophages that come in, that are more active and in autophagy, and then have good lysosomal capacity that keeps degrading the lipid present in the plaque and tries to ingest it, but also as a consequence keeps releasing some of the degraded cholesterol into the milieu where the smooth muscle cells that are proliferating are internalizing it and becoming more foamy. So these are really great open questions that need to be addressed in the field. Cindy St. Hilaire: So drug-eluting stents are coated with rapamycin or the various chemical compositions that are derived from rapamycin. And rapamycin itself induces autophagy. So while the thought behind using this coating on stents was to prevent smooth muscle cell proliferation, and thus restenosis or ingrowing of the stent, your study suggests that this could also help to promote autophagy in the cells underlying the stent. So has anyone gone in and looked at plaques that have been stented and either failed or not, and investigated the foam cell content or markers for autophagy activity? Mireille Ouimet: Not to my knowledge, and this has been something we've definitely... We think that this is what's happening. Some of the protective effects of these drug-eluting stents that have everolimus or sirolimus or the rapamycin or rapamycin analogs, we do believe that some of their protective effect can be attributed to autophagy activation, but this remains to be demonstrated. We think that autophagy activation locally would promote reverse cholesterol transport and would be one of the processes that prevents restenosis because we can promote the efflux of cholesterol out. Cindy St. Hilaire: Great. So I guess stemming from my question on the stents, what are the other translational implications of the findings of your study? And what would you like to see come out of this? Mireille Ouimet: So one of the things is, as Sabrina mentioned, would be to target both foam cell populations because it seems as though the vascular smooth muscle cell foam cells are very much defective in their autophagy capacity, and they're very poor effluxes, but we could potentially restore autophagy in the cell population to promote reverse cholesterol transport. And looking at prevention of atherosclerosis is a bit different than looking at regression, because regression is at a later stage where the plaques are more advanced. And if they're mostly vascular smooth muscle cell-derived, maybe then those drugs that we're considering that protect against the development of atherosclerosis are effective on the macrophage themselves early on, but might not be mimicking what we would see in the clinic where the patients that present are older. Cindy St. Hilaire: Yeah, it's kind of really reminiscent of like the CANTOS trial and like, where do we want to target the therapy? It's going to be very different if it's an early smaller plaque, versus a late-stage possibly pro close to rupturing type of plaque. Well, Sabrina Robichaud and Dr Ouimet, thank you so much for joining me today. Congratulations again on a wonderful study, and I'm really looking forward to hearing more about this from your group. Sabrina Robichaud: Thank you. Mireille Ouimet: Thank you very much. And we also want to thank all the co-authors on the study, specifically also Adil Rasheed, who is co-first author on the work and Katey Rayner's group for all the support and involvement in this study. Cindy St. Hilaire: That's it for the highlights from the March issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle @circres and #DiscoverCircRes. Thank you to our guests, Sabrina Robichaud and Dr Mireille Ouimet Sabrina. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles was provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire and this is Discover CircRes, you're on-the-go source for the most up-to-date and exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022, The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.
Guest: Karon Liu, food reporter Two years of a pandemic have changed the hospitality industry, including the way we look at labour, essential workers, the way we eat and our relationship with food. The Star's food reporter Karon Liu and food writer Suresh Doss have kept us updated by sharing the best of what the city has to offer our taste buds from a hidden food court at the back of a flea market to a delicious new pierogi spot in an old church basement. Liu joins “This Matters” to discuss the latest pandemic food trends.
I'm having trouble with posting the podcast to iTunes, so I'm trying again with our latest conversation to see what happens! … More Stop the Culture Wars: A Plea to the US Left (ft. Chris Cutrone, Matt Christman, Catherine Liu)
Full article: https://www.ajronline.org/doi/10.2214/AJR.21.27129 Xiaochen D. Liu, MD discusses an article that assesses the utility of preoperative shear wave elastography measurements of the supraspinatus muscle to predict successful rotator cuff repair, including comparison with MRI-based measures.
right march, tweet and put flags on their pickup trucks. Their main accomplishment is to blame the other side for their favorite problems, expiate their responsibility and guilt, and eliminate the possibility of positive change on any of their issues. Spencer and Laurie focus in on the US left, because their disappointment in that group is more profound. … More Stop the Culture Wars: A Plea to the US Left (ft. Chris Cutrone, Matt Christman & Catherine Liu)
DairyVoice host Juan Piñeiro talks with Dr. Zong Liu, discussing cow manure and his research on balancing the release of nutrients in soil. Dr. Liu's research goals focus on separating nutrients to the solids, making “the perfect fertilizer”. A higher value manure product. Also discussed is Liu's solar powered, self-controlled, boat project, used to improve lagoon water quality and reduce emissions.
Dr. Joanne Liu has a fascinating life story. She is currently a pediatric emergency medicine physician, Associate Professor of Medicine at the University of Montreal, and Professor of Clinical Medicine at McGill University. She is also the former International President of Medicins Sans Frontieres, or Doctors Without Borders. In this episode of Digging Deep, Dr. Liu shares her deeply informed perspective on the many lessons of the pandemic, including how we failed to unite globally in response to COVID-19 and how we might repeat that mistake in the future. She also shares remarkable stories about her childhood as the daughter of immigrants, her experiences providing care in some of the most devastated areas of the world, why you should be a giver instead of a taker, and how she set out with the goal of changing the world, but it was actually the world that changed her. See omnystudio.com/listener for privacy information.
Czy Azjata może zrozumieć Chopina? – Urodziłem się w Paryżu, pochodzę z Chin, ale wychowywałem się w Kanadzie. Taka wielokulturowość sprawia, że jestem otwarty na różne rzeczy. W muzyce to niezwykle ważne. Aby grać Beethovena albo muzykę rosyjską, niemiecką czy włoską, wcale nie musimy być Włochami czy Niemcami. Można przystosować się do różnych kultur, a mnie to przychodzi wyjątkowo łatwo – mówi zwycięzca Konkursu Chopinowskiego Bruce Liu.
Amy Liu, founder of Tower28 Beauty is the guest on today's show. For over 15 years, Amy Liu worked as a beauty executive at some of the fastest growing prestige beauty companies, including Smashbox, Kate Somerville and Josie Maran Cosmetics. But as a longtime eczema sufferer, Amy couldn't even enjoy the best part of working in the beauty industry: trying out all the products and treatments. Even the clean alternatives were super expensive or too clinical, like they were coming straight from the doctor's office. Amy wondered why there was no in-between. Where were the fun, cool, wallet-friendly products that were also gentle and safe? So she set out to create Tower 28, a beauty company inclusive of all skin tones, skin types, budgets, and beauty philosophies. This episode covers: Steps to prepare for success before launch: from trademarks to securing your social handles The influencer that generated 1,000 orders at Tower28's launch Surprising benefits of partnering with Sephora Tower28 started a Clean Beauty School for founders! https://www.tower28beauty.com/pages/clean-beauty-summer-school-2021 The new shift in influencer and press gifting that's leveling the playing field for young brands (you need to know this before sending out product!) How Tower28's creating constant newness for their customer Links Join the 'NFT Use Cases for Consumer Brands' Workshop: https://momence.com/s/651097
Shoutout to Brooklyn, NY Coney Island's own emcee Lil Dee for coming on my show for an interview! Lil Dee talked about his father introducing him to classic Hip-Hop, participating at cyphers at the age of 12, and how Michael Rapaport saved his life. He discussed his transition from his first Another Day On The Island EP to his newest They Call Me Danny James EP and getting back to his boom bap style. He got into combining himself, Danny, and his rap identity, Lil Dee, together, dealing with jealousy, and keeping a small circle of loyal friends. He announced that he has accepted an offer to attend college at LIU in the fall and will be majoring in music production under the Roc Nation program to start producing music. He plans on staying independent unless the right deal comes along and that he won't be dropping any major projects until he feels as though the time is right. Stay tuned! Lil Dee's music is available on all platforms, including YouTube: https://www.youtube.com/c/LilDeeRaps and Apple Music: https://music.apple.com/us/artist/lil-dee/1544997457. Follow Lil Dee on Instagram: @lildee_raps and Twitter: @lildeeraps Follow me on Instagram and Twitter: @thereelmax. Website: https://maxcoughlan.com/index.html. Website live show streaming link: https://maxcoughlan.com/sports-and-hip-hop-with-dj-mad-max-live-stream.html. MAD MAX Radio on Live 365: https://live365.com/station/MAD-MAX-Radio-a15096. Subscribe to my YouTube channel Sports and Hip Hop with DJ Mad Max: https://m.youtube.com/channel/UCE0107atIPV-mVm0M3UJyPg. Lil Dee on "Sports and Hip-Hop with DJ Mad Max" visual on YouTube: https://www.youtube.com/watch?v=BDbEpGH54uM.
The weekly radio show from Alok. 01. Alok feat. Nonô - Sky High02. Alesso & Katy Perry - When I'm Gone03. Alle Farben & HUGEL feat. FAST BOY - Castle04. Yves V & Cat Dealers feat. Coldabank - Just Wanna Be Loved05. Bruno Be, Sandeville, Alexandra Prince - So Many Times06. Alok feat. Au/Ra - Side Effect [PREMIÈRE]07. Thomas Feelman & Polina Grace - Keep Us Together08. Lucas & Steve feat. Laura White - Set You Free09. Blonde feat. Alex Newell - All Cried Out10. Martin Solveig & Dragonette - Hello11. Sigala - Melody12. Liu, Hawk & Erjona Sylejmani - Hanging Tree13. Monocule & LAMAS - Your Eyes14. Keanu Silva, Toby Romeo & SACHA - Hopeless Heart15. Öwnboss & Sevek - Move Your Body16. Gabe & Tough Art feat. Céu - Malemolência17. Bhaskar, Nalestar & Linas Music feat. Carl Wallis - No No No18. Dubdogz & Ten Tonne Skeleton feat. H. Kenneth - Love Goes (On & On)19. Anyma - Running20. Alok & Steve Aoki feat. Lars Martin - Typical
This article taps into many areas of interest for game scholars and community members: disruptive gaming, playful resistance, games that subvert capitalism, and ways to spread and inspire political action. Listen in! Huang, V. G., & Liu, T. (2022). Gamifying Contentious Politics: Gaming Capital and Playful Resistance. Games & Culture, 17(1), 26–46.
The weekly radio show from Alok. 01. Alok & Steve Aoki feat. Lars Martin - Typical02. ACRAZE feat. Cherish - Do It To It03. James Hype feat. Tita Lau - Disconnected04. Alok feat. John Martin - Wherever You Go (Alle Farben Remix)05. Kohen, Nalestar & Sean Prusko - Breaking Down06. Dubdogz & Ten Tonne Skeleton feat. H. Kenneth - Love Goes (On & On) [PREMIÈRE]07. RÜFÜS DU SOL - You Were Right08. Adam Lambert - Ghost Town09. HUGEL x Jude & Frank - La Candela Viva10. Robert Falcon., Harris & Ford feat. JUSTN X - The Sound11. Alok - Squid Game (Let's Play)12. James Hype - Dancing13. Alok, Sofi Tukker & INNA - It Don't Matter (Alok & ÜHÜ Remix)14. Liu, Hawk & Erjona Sylejmani - Hanging Tree15. Tiesto & Ava Max - The Motto16. Bhaskar & Valiant - Don't Call Me Baby17. MEDUZA feat. Hozier - Tell It To My Heart18. Anyma feat. Meg Myers - Running19. Öwnboss & Sevek - Move Your Body20. Alok feat. Nonô - Sky Hig
The weekly radio show from Alok. 01. Alok feat. Nonô - Sky High02. ACRAZE - Do It To It03. Tiësto & Ava Max - The Motto04. Alok feat. John Martin - Wherever You Go (with Alan Walker) [PREMIÈRE]05. Alok & Steve Aoki feat. Lars Martin - Typical06. Liu, Hawk, Erjona Sylejmani - Hanging Tree07. Tiësto - God Is A Dancer08. Michael Calfan - Silhouette09. Marc Benjamin - Turn Back Time10. Oliver Heldens feat. K Stewart - Last All Night (Koala)11. Elton John & Dua Lipa - Cold Heart (Pnau Remix)12. Elderbrook - I'll Find My Way13. Rain Radio - Talk About14. Bruno Be, Sandeville, Alexandra Prince - So Many Times15. Bhaskar & Valiant - Don't Call Me Baby16. Kohen, Nalestar, Sean Prusko - Breaking Down17. Meduza feat. Hozier - Tell It To My Heart18. Ben Kim - Somebody To Love19. Vintage Culture - You Give Me A Feeling20. Gabry Ponte - Thunder
The weekly radio show from Alok. 01. Alok & Daniel Blume - Rapture02. Liu, Hawk & Erjona Sylejmani - Hanging Tree03. Pontifexx & DES3ETT feat. Amanda Collis - Blinded04. SPECT3R - All I Wonder05. RQntz & Berchi feat. Siera - Hurting Me Inside06. Alok & Steve Aoki feat. Lars Martin - Typical07. Yves V - Echo08. Bhaskar feat. 2STRANGE - Power In My Soul09. Alok & Vintage Culture feat. Oxia - Domino10. MOGUAI, Selva & Bright Sparks - Nitro11. Laidback Luke & Lost Boy with Dubdogz - Home Alone12. LANNÉ & Hawk feat. Leo - Had To Tell You13. Alok, Sofi Tukker & INNA - It Don't Matter14. WILL K feat. ANML KNGDM - Honestly15. Alok, ALOTT & Apophis - Alone16. Bruno Be, Sandeville & Alexandra Prince - So Many Times17. Hollaphonic & FFlora - Visions18. Alok feat. John Martin - Wherever You Go19. Alok & Vize feat. Alida - Love Again20. Alok feat. Nonô - Sky High
Hello and welcome to the final episode of The Ice Skating Podcast this year!We are wrapping up the rollercoaster ride that has been 2021, and discussing all the main talking points of this season. There is some top-flight Speed Skating action to review, including the ISU World Cups in Salt Lake City and Calgary, and we've got interviews with Joey Mantia, Femke Kok, Kjeld Nuis, Francesca Lollobrigida and Nils Van de Poel, among others.From Anna Sherbakova to Nathan Chen, Guillume Cizeron and Gabriella Papadakis to Laura Barquero and Marco Zandron, there's been so much to discuss in Figure Skating, while in Short Track it's been an amazing year for Suzanne Schulting, Kristen Santos, the Liu brothers, Pascal Dion and many others. We run the rule across them all.The Ice Skating Podcast is the official pod of the International Skating Union, and is hosted by Nick Moore and Luke Norman. The pod will be taking a break over the holidays, and will return in early January.
The weekly radio show from Alok. 01. Tiesto & Karol G - Don't Be Shy02. Rain Radio & DJ Craig Gorman - Talk About03. Joel Corry, Jax Jones feat. Charli XCX & Saweetie - OUT OUT (Alok Remix)04. Liu, Hawk, Erjona Sylejmani - Hanging Tree05. Alok feat. John Martin - Wherever You Go06. Hollaphonic & FFlora - Visions07. Jack Back x Fancy Inc x Roland Clark - Alive08. Wankelmut, Selva & MATTN - Scary Monsters09. Sharam - Party All The Time10. Justice - D.A.N.C.E11. Bruno Be & Sandeville feat. Alexandra Prince - So Many Times12. Joel Corry & Mabel - I Wish13. Laidback Luke & Dubdogz feat. Lost Boy - Home Alone14. Tiesto & Ava Max - The Mottto15. ACRAZE feat. Cherish - Do It To It16. MEDUZA feat. Hozier - Tell It To My Heart17. Purple Disco Machine feat. Eyelar - Dopamine (John Summit Remix)18. Cristoph x Artche - Illusions19. James Hype - Dancing20. Bhaskar feat. 2STRANGE - Power In My Soul21. Ed Sheeran - Shivers (Alok Remix)
The weekly radio show from Alok. 01. Tiesto & Ava Max - The Mottto02. Alok feat. John Martin - Wherever You Go03. Joel Corry & Mabel - I Wish04. Laidback Luke & Dubdogz feat. Lost Boy - Home Alone 05. Alok, Alott & Apophis - Alone06. Liu, Hawk, Erjona Sylejmani - Hanging Tree07. Elton John & Dua Lipa - Cold Heart (PS1 Remix)08. CamelPhat & Elderbrook - Cola09. Miguel Campbell - Something Special10. Tiësto, Ummet Ozcan & Tomhio - Be SomethingSteve Aoki - Guest Mix11. Alok & Steve Aoki feat. Lars Martin - Typical12. Steve Aoki, Chemical Surf & Zafrir feat. Max-Africana - Siliwa Hay13. MT11 - Don't Waste My Time14. Steve Aoki presents Ninja Attack - Aurora15. Farruko - Pepas (Steve Aoki Remix)16. Steve Aoki, GATTÜSO & Aukoustics feat. MKLA - Losing My Religion17. Steve Aoki & Armin Van Buuren - Music Means Love Forever18. Steve Aoki & Gammer - Incoming19. Steve Aoki, Jolin Tsai & MAX - Equal In The Darknes
The weekly radio show from Alok. 01. Ed Sheeran - Shivers (Alok Remix)02. MEDUZA feat. Hozier - Tell It To My Heart03. ACRAZE feat. Cherish - Do It To It04. Alok feat. John Martin - Wherever You Go05. Liu, Hawk, Erjona Sylejmani - Hanging Tree [PREMIÈRE]06. Bhaskar feat. 2STRANGE - Power In My Soul07. Duke Dumont feat. A*M*E - Need U (100%)08. Martin Solveig feat. Ina