Podcast appearances and mentions of elizabeth nance

Link to the 5 Calls Website for contacting your representative (including a script specifically for this issue): https://5calls.org/issue/nih-nsf-funding-cuts/ Dr. Elizabeth Nance's Instagram: @profnance To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy.  Intro and Outro music composed and produced by Julienne Ellen.   

Sermon given by The Reverend Dr. Elizabeth Nance-Coker on November 13, 2022.

In today's episode, Dr. Tommy Wood returns for his fifth appearance on STEM-Talk. Tommy is a UK-trained physician and an assistant research professor of pediatrics at the University of Washington. He also is a visiting research scientist and a valued colleague of ours here at IHMC. Today's interview focuses on a new paper that Tommy just had published by the American Society for Microbiology. It's titled, “Reframing Nutritional Microbiota Studies To Reflect an Inherent Metabolic Flexibility of the Human Gut: A Narrative Review Focusing on High-Fat Diets.” We discuss the paper and follow up on some research Tommy has done since his last appearance on STEM-Talk, a two-part interview that took place a little more than a year ago. In that two-part interview, episodes 110 and 111, we touched on Tommy's research into the importance of metabolic health and how only one in eight Americans is considered metabolically healthy. We also talk to Tommy about a new grant he just received to examine the effects of azithromycin on premature brain injury in a ferret model. As part of this grant, Tommy will be collaborating with his wife, Dr. Elizabeth Nance, who also is an assistant professor at the University of Washington and was our guest on episode 71 of STEM-Talk. Show notes: [00:03:15] Dawn opens the interview mentioning Tommy's new paper published by the American Society for Microbiology titled “Reframing Nutritional Microbiota Studies to Reflect an Inherent Metabolic Flexibility of the Human Gut: A Narrative Review Focusing on High-Fat Diets.” Dawn mentions that in our last interview with Tommy, he talked about the importance of insulin sensitivity and metabolic health, yet as Tommy has pointed out, more than 80 percent of Americans have some kind of metabolic disease or dysfunction. Given that, Dawn asks Tommy to revisit key points regarding insulin resistance; the importance of metabolic health; and why so many Americans struggle with this issue. [00:06:18] Ken points out that the common view held in much of the nutritional-microbiota research is that high-fat diets are harmful to human health, at least in part through their modulation of the gut microbiota. Ken goes on to say that there are a number of studies that support the inherent flexibility of the human gut and our microbiota's ability to adapt to a variety of food sources, suggesting a more nuanced picture than the commonly held view. Ken asks Tommy to give an overview of the gut microbiome and how research in the past decade has explored the effects of the gut microbiome on our metabolism, immune systems, our sleep, and our moods and cognition. [00:09:50] Dawn asks Tommy to explain the history of how fat, and high-fat diets, became public enemy number one in many circles, including gut microbiome research. [00:12:46] Ken mentions that there are many limitations when it comes to preclinical nutritional research, with many studies on the role of fat in the diet being based on animal models, particularly rat models, which presents several problems since the natural diet of a mouse is low in fat and high in carbohydrates. [00:15:50] Ken asks Tommy about the need for a more nuanced view of fat and our microbiota's ability to adapt to different food sources. [00:17:33] Ken points out that while people might throw around the term “healthy gut microbiota,” the research into the gut microbiota is so new that we don't yet know for sure what a healthy gut microbiota should look like. [00:21:22] Ken asks Tommy how we should go about reframing the debate about fat and high-fat diets to better reflect the overall evidence. [00:23:48] Dawn mentions that in the past decade, researchers have significantly improved our understanding of the gut microbiome. She asks about Tommy's belief that there is a need to understand the gut microbiome in an evolutionary context as well. [00:25:18] Tommy gives an overview of the gut-barrier function and its role in ...

Join us for a conversation with Professor Elizabeth Nance of the University of Washington, the founder of Women in Chemical Engineering! Links mentioned can be found here: http://www.wcheusc.com/academics.html.

Dr. Tommy Wood is a UK-trained physician who is making his third appearance on STEM-Talk. Earlier this year before the COVID-19 outbreak, Tommy gave a well-attended lecture at IHMC about the latest research on building and preserving brain health across people’s lifespans. The lecture was so popular we invited Tommy to join us for another STEM-Talk interview. Tommy is a research assistant professor of pediatrics in the University of Washington Division of Neonatology. He was our guest on episodes 47 and 48 of STEM-Talk. Tommy received his undergraduate degree in biochemistry from the University of Cambridge and a medical degree from the University of Oxford. In addition to working with newborn infants who have brain injuries, Tommy also develops performance optimization strategies for athletes such as Formula 1 racecar drivers and Olympians. As in our first STEM-Talk interview with Tommy, our conversation was so long and wide-ranging that we have divided it into two parts. In today’s episode, we talk to Tommy about the importance of metabolic health, especially as a way to protect ourselves from COVID-19. We touch on Tommy’s work at developing accessible methods to track human health and longevity, and also his research an assistant professor of pediatrics at the University of Washington where he studies ways to increase the resilience of developing brains. In part two of our interview, we talk to Tommy about his continuing research into lifestyle approaches to improve health span and lifespan and physical performance. We also have a fascinating discussion about the physiological and metabolic responses to brain injury and their long-term effects on brain health.  Show notes:  [00:05:15] Dawn asks about an article Tommy and a colleague recently wrote, in which Tommy points out that it is becoming increasingly clear that underlying conditions associated with suboptimal metabolic health appear to be associated with poor outcomes in patients with COVID-19. Considering the nature of these underlying conditions, such as obesity and hypertension, he argues that lifestyle-based approaches to protecting ourselves from COVID-19 are likely to be one of our best tools in addressing this ongoing pandemic as well as future pandemics. Tommy summarizes his key points from the article. [00:09:38] Dawn mentions that when Tommy was last interviewed on STEM-Talk, he had just become a senior fellow at the University of Washington and was in the process of moving permanently to the U.S. She goes on to mention that when she asked Tommy what brought him to the states, he said “a girl,” who he ended up marrying. The girl turned out to be Elizabeth Nance who was interviewed on episode 71 of STEM-Talk. Dawn asks how Elizabeth is doing. [00:10:51] Tommy gives an overview of his work as a research assistant professor of pediatrics at the University of Washington in the division of neonatology, where his focus is on ways to increase the resilience of developing brains and also ways to treat neonatal brain injuries. [00:12:45] Dawn explains that Tommy gives a disclaimer at the beginning of his talks that “many of my best ideas are stolen.” She asks what are his best sources for ideas. [00:14:42] Dawn mentions that when Elizabeth was on STEM-Talk, she mentioned that Tommy was constantly reading paper after paper, to the point that it is dizzying to look at Tommy’s computer screen. Tommy describes his research methods and how he goes about collecting material. [00:16:51] Ken mentions that Tommy’s current research interests include the physiological and metabolic responses to brain injury and their long-term effects on brain health. Ken asks about this as well as Tommy’s work to develop easily accessible methods to track human health, performance, and longevity. [00:18:59] Dawn asks why even as a neonatal neuroscientist, Tommy is still interested in working with football players, Formula 1 drivers,

Dr Elizabeth Nance has an impressive track record. Now a Clare Boothe Luce Assistant Professor of Chemical Engineering at the University of Washington, USA, Dr Nance’s work centres around the use of nanoparticles to deliver therapeutic agents to the brain, a seemingly simple operation which is confounded by a highly regulated blood brain barrier which prevents access to the brain and a complex brain environment which prevents access to diseased cells. Her current work also investigates the potential use of nanoparticles to probe tissue environments to map tissue structure, and how tissue structure changes in the presence of a disease.

"Getting the home ready for Spring market" is this month's theme. Billy Bjorklund talks remodeling projects and Kim Vestal and Elizabeth Nance are in the studio to discuss today's topics. Julie talks about the Battle of Guilford Courthouse.

"Getting the home ready for Spring market" is this month's theme. Billy Bjorklund talks remodeling projects and Kim Vestal and Elizabeth Nance are in the studio to discuss today's topics. Julie talks about the Battle of Guilford Courthouse.

Elizabeth Nance earned a PHD Chemical and Biomolecular Engineering from John Hopkins and is an Assistant Professor in Chemical Engineering at the University of Washington focused on nanotechnology – you can see here page here at Nance Lab. [0:37] Elizabeth did not always know she wanted to go into engineering, in high school she looked into many different career paths. [1:40] Why she chose Chemical Engineering and Bio-molecular Engineering and not a doctor. A mentor she trusted – if she did not actually want to treat people but rather wanted to work to solve disease and why they occur – the PHD in Engineering was a better choice. – Chemical Engineering is not an applied Chemistry degree it is a lot of math and physics and this can be applied in the health field. [5:33] Getting into the bio-molecular aspect and how she is applying nano-technology. She does a lot of imaging with the brain and uses nano-technology as a probe in the brain to see how they interact with the brain especially when there is an injury. [7:40] As a professor Elizabeth gets into questions that she receives on a regular basis from students on how the different engineering degrees can be applied in the health field – there is no right degree. [13:22] An ah-ha moment Elizabeth turned into success – working in a lab focusing on mucus and working on drugs that can pass through the mucus membrane. Mucus really does protect you so makes it very challenging to get a drug across it. You can design nano-particles to pass through the mucus membrane. She was doing this in her first year of her PHD work. [19:00] Best piece of advice is from her dad – when getting anxious; be yourself, take a deep breath , and smile. A habit for success is to keep a list of what needs to be done and always tries to seek feedback. [19:50] Parting guidance – just get out there and try things and invest fully in those experiences. You can get a free book from Audible at www.stemonfirebook.com and can cancel within 30 days and keep the book of your choice with no cost. Free Audio Book from Audible.

Science, technology, engineering and mathematics (STEM) - It’s a group of academic disciplines and professions that have historically been male-dominated. In 2017, women held 47% of all jobs in the US, but only 24% of STEM jobs. As a result, we are lacking the perspectives of women in fields that contribute heavily to our progress as a society. On the podcast today, NBT Scientific Director Megan Roberts is talking with Elizabeth Nance, PhD, and Brianna Stubbs, PhD, scientists leading teams of researchers in the areas of biotechnology and physiology. The trio talk about the unique aspects of being women in scientific fields, including the importance of allies and mentors, imposter syndrome, and identifying your own biases. Here’s the outline of this interview with Elizabeth Nance and Brianna Stubbs: [00:00:23] Elizabeth's STEM-Talk podcast. [00:00:49] Previous podcasts: Elizabeth: Nanotechnology: The Big Impact of Tiny Particles; Brianna: World Champion Rower and Ketone Monoester Researcher Brianna Stubbs; The D-BHB Ketone Monoester Is Here. [00:01:08] HVMN. [00:03:01] Science, technology, engineering, and mathematics (STEM). [00:09:50] Positive Discrimination [00:12:59] Nature vs nurture; causes of women’s underrepresentation in science. Studies: Ceci, Stephen J., and Wendy M. Williams. "Understanding current causes of women's underrepresentation in science." Proceedings of the National Academy of Sciences (2011): 201014871, and Cheryan, Sapna, et al. "Why are some STEM fields more gender balanced than others?." Psychological Bulletin 143.1 (2017): 1. [00:15:57] Freakonomics Podcast: What Can Uber Teach Us About the Gender Pay Gap? [00:18:36] Chemical engineering: 30% women. [00:21:57] Mentorship. [00:22:53] Prof. Kieran Clarke, University of Oxford. [00:23:36] #MeToo Movement. [00:24:28] Allies in the workplace. [00:25:25] Service to the department. [00:29:00] Diversity and mentorship. [00:31:01] Fluid mentor/mentee roles and boundaries. [00:34:05] Women in Chemical Engineering. [00:37:37] Gender differences in mentoring. [00:40:44] Work-life balance. [00:47:02] Judgment and criticism from others. [00:50:29] Parenting. [00:56:44] Letting the work speak for itself vs. focusing on minority status. [01:00:22] Book: Whistling Vivaldi: How Stereotypes Affect Us and What We Can Do (Issues of Our Time), by Claude M. Steele. [01:00:26] Self-fulfilling effect of stereotypes. [01:05:35] Imposter syndrome. [01:12:15] Embracing failure. [01:14:27] University of Washington Resilience Lab. [01:17:15] Being a catalyst for progress. [01:17:17] Conscious use of language. Article: Letters of recommendation for women more likely to raise doubts. [01:25:52] Defining success. [01:28:36] Brene Brown Ted Talks: The Power of Vulnerability and Listening to Shame. [01:29:04] Book: How Successful Women Think: It's All In The Mind, by Latrell King. [01:30:00] Additional articles: 1. These labs are remarkably diverse — here’s why they’re winning at science; 2. 4 Ways Women Can Build Relationships When They Feel Excluded at Work; 3. The uncomfortable question powerful women should answer; 4. Where Women Must Defy the Odds to Become Scientists; 5. These are the 10 best and worst states for women.

Dr. Elizabeth Nance received her Ph.D. from Johns Hopkins University in Chemical & Biomolecular Engineering and is now an Assistant Professor at the University of Washington. She leads a research team in the study of nanoparticles that are capable of targeting disease in the brain. Elizabeth has received numerous awards for her groundbreaking work, and was named one of Forbes 30 under 30 in Science in 2015, described as one of the “most disruptive, game-changing and innovating young personalities in science.” In this podcast NBT Scientific Director Megan Roberts interviews Elizabeth about her research in nanotechnology and its application in medical development and delivery. They discuss the potential applications of her work for the diagnosis and treatment of debilitating diseases such as cancer, Alzheimer’s, and Parkinson’s. They also talk about the message behind Elizabeth’s 2016 TED talk on the importance of exploring unfamiliar territory as a catalyst for growth and mastery. Here’s the outline of this interview with Elizabeth Nance: [00:00:41] Book: How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence, by Michael Pollan. [00:06:30] Nanotechnology. [00:11:42] Justin Hanes, PhD. [00:11:51] Mucosal barrier. [00:15:36] Increasing distribution of particles within brain. [00:17:28] Polyethylene glycol. [00:20:39] Diffusion and convection. [00:27:25] Nanoparticles. [00:33:28] Increasing diffusive capability for improved drug efficacy. [00:34:05] Curcumin study: Joseph A., Wood T., Chen C-C., Corry K., Juul S., Snyder J., Parikh P., Nance E. Curcumin-loaded brain penetrating nanoparticles for treatment of neonatal hypoxia-ischemia encephalopathy. In press, Nano Research. [00:35:13] Nanotechnology in cancer. [00:39:10] Generalizing from animal models. [00:46:40] Childhood cerebral adrenoleukodystrophy. [00:48:25] Video: Specializing in Not Specializing | Elizabeth Nance | TEDxUofW. [00:48:53] Interdisciplinary collaboration. [00:53:14] Book: Mindset: The New Psychology of Success, by Carol Dweck, Ph.D. [01:00:02] Freedom to fail. [01:01:45] Blood Chemistry Calculator; Tommy Wood, MD, PhD; Dr. Bryan Walsh. [01:02:06] Machine learning. [01:06:12] nancelab.com; blog; Facebook; Instagram.

Episode 71: Elizabeth Nance talks about using nanotechnology to understand and treat brain diseases SEO: Elizabeth Nance, Nance Lab, University of Washington, nanotechnology, autism, traumatic brain injury, epilepsy, nanoparticles, blood-brain barrier,diffusion,dendrimer-NAC conjugates,Einstein’s brain, chemical engineering,Ken Ford,Dawn Kernagis,IHMC Our guest today has been described by Forbes magazine as one of the “most disruptive, game-changing and innovating young personalities in science.” Dr. Elizabeth Nance is known for her passionate search to find ways to more efficiently connect resources and information across multiple scientific and engineering disciplines. Her research focuses on using nanotechnology to understand the movement of molecules in the brain. She is particularly focused on better ways to treat brain diseases like autism, stroke, traumatic brain injury and epilepsy. Elizabeth is the Clare Boothe Luce Assistant Professor of Chemical Engineering at the University of Washington. She also has an adjunct appointment in the school’s radiology department. Elizabeth and her lab, the Nance Lab, recently was awarded a $1.8-million-dollar grant from the National Institutes of Health to develop quantitative, high resolution imaging and analysis platforms to understand nanoparticle behavior, with a specific focus on the brain. In today’s episode, we discuss: The pushback Elizabeth received in college when she tried to apply chemical engineering to neurological diseases. [00:11:33] How Elizabeth developed the first nanoparticles that could penetrate deep within the brain. [00:13:52] The many potential applications of nanoparticle technology in the treatment of neurological disorders, diseases and injuries. [00:17:10] The structure, and unique functions of the blood-brain barrier. [00:28:11] The dendrimer-NAC conjugates, and how they increase intracellular glutathione to reduce injury in the inflamed brain. [00:35:01] How “disease directing engineering” has the potential to allow for the leveraging of common hallmarks of neurological disease to better deliver therapies. [00:40:19] How change in brain metabolism affects targeted therapeutic deliveries to a specific region of the brain. [00:52:14] Show notes: [00:03:31] Elizabeth talks about growing up in North Carolina and how her family goes back nine generations to the original homesteaders of Charlotte. [00:04:06] Dawn mentions that Elizabeth liked to spend a lot of time outdoors as a child and asks her if it is true that she was especially good at climbing trees. [00:05:12] Dawn asks Elizabeth about her hectic schedule in high school, which, in addition to her studies, included soccer, track and volleyball. [00:06:03] Ken asks Elizabeth when she became interested in science. [00:08:22] Dawn mentions how in North Carolina a person has to decide early on if they are a Chapel Hill fan or a North Carolina State fan. Dawn asks if this culture contributed to Elizabeth going to NC State. [00:09:28] Dawn asks Elizabeth about her decision to major in chemical engineering. [00:11:33] Dawn asks Elizabeth to discuss the pushback she received in college when she tried to apply chemical engineering to neurological diseases. [00:13:52] Ken mentions that Elizabeth developed the first nanoparticles that could penetrate deep within the brain. This was a major reason why Forbes named her one of its “30 Under 30 Disruptive Influencers in Science” back in 2015. He asks if she could talk about the work she did in developing that platform and how it changed the way we might think about delivering drugs in the brain. [00:17:10]Ken mentions that there are many potential applications of nanoparticle technology in the treatment of neurological disorders, diseases and injuries. He asks Elizabeth to describe the structure of a nanoparticle in general, and how it can accomplish targeted delivery of a therapeutic.

Elizabeth Nance from the University of Washington talks about the use of nanoparticles to treat neurological diseases. We discuss what makes nanoparticles such interesting vehicles for delivering drugs to the brain, how her lab interrogates this process, and why laboratory success so often fails to translate into people. Elizabeth also shares her perspective on how to train future scientists and engineers to operate in a complex, interdisciplinary world. When a conversation begins with a story of a stolen brain, you know it's going to be good! Show details: • Hosted by Michael Filler (@michaelfiller) • Edited by Andrew Cannon (@andrewhcannon) • Recorded on February 5, 2018 • Show notes are available at http://www.fillerlab.com/nanovation/archive/35 • Submit feedback at http://www.fillerlab.com/nanovation/feedback

Elizabeth Nance from the University of Washington talks about the use of nanoparticles to treat neurological diseases. We discuss what makes nanoparticles such interesting vehicles for delivering drugs to the brain, how her lab interrogates this process, and why laboratory success so often fails to translate into people. Elizabeth also shares her perspective on how to train future scientists and engineers to operate in a complex, interdisciplinary world. When a conversation begins with a story of a stolen brain, you know it's going to be good! Show details: • Hosted by Michael Filler (@michaelfiller) • Edited by Andrew Cannon (@andrewhcannon) • Recorded on February 5, 2018 • Show notes are available at http://www.fillerlab.com/nanovation/archive/35 • Submit feedback at http://www.fillerlab.com/nanovation/feedback