Podcast appearances and mentions of Brianna Stubbs

In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Brianna Stubbs, an expert in exogenous ketone metabolism. Dr. Stubbs shares her journey from being a competitive rower to becoming a scientist. She dives into her research on ketone biology and its implications for health and aging.Dr. Stubbs discusses the science behind ketones, explaining how they serve as an alternative fuel for the brain and body, particularly during periods of low carbohydrate intake. She highlights the potential benefits of ketones for cognitive function and heart health, noting their ability to act as signaling metabolites that influence oxidative stress and inflammation.The conversation also explores the practical applications of ketone supplements for athletes and the general public. Dr. Stubbs emphasizes the importance of personalized approaches to diet and supplementation, considering individual goals and health conditions. She provides insights into her ongoing research at the Buck Institute, aiming to translate scientific discoveries into practical tools for healthy aging.

The Buck Institute, a pioneer in aging research, is uncovering how ketones impact healthspan. Dr. Brianna Stubbs, a world-champion athlete turned researcher, shares insights on how these molecules are more than just an energy source. They act as potent signaling molecules, influencing key aging pathways. Learn about the institute's groundbreaking work and how ketone drinks might help us live better, longer. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we have our good friend and colleague Dr. Dominic D'Agostino returning for his third appearance on STEM-Talk. Dom, as most of our longtime listeners know, is well-known for his research into the ketogenic diet and the physiological benefits of nutritional ketosis. Since our last conversation with Dom in 2019, a tremendous body of research has been added to the literature about the therapeutic potential of ketosis. The high-fat, low-carb ketogenic diet has been linked to advances in the treatment of Alzheimer's, cancer, migraines, type-2 diabetes, psoriasis, sleep apnea, psychiatric disorders, traumatic brain injuries as well as a host of other diseases and disorders, which we cover in today's interview. In episode 14 of STEM-Talk, we talked to Dom about his development and testing of metabolic therapies involving the ketogenic diet for a wide range of diseases and conditions. In episode 87, Dom returned to reflect on his 10 years of research focused on the high-fat/low-carbohydrate diet. In today's interview, we talk to Dom about this latest work as well as his extensive research on hyperbaric oxygen. Dom is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani. He specializes in neuroscience, molecular pharmacology, nutrition, and physiology. Dom also is our colleague and a research scientist here at the IHMC. Show notes  [00:02:50] Dawn opens the interview mentioning Dom's recent IHMC Evening Lecture, in which he mentions the film “First Do No Harm” starring Meryl Streep. The film is based on the true story of a four-year-old boy diagnosed with severe epilepsy, whose extreme seizures continued despite extensive medical treatments. The boy's mother reached to Dr. John Freeman, a physician who had successfully treated patients with a ketogenic diet. Dawn asks Dom to give some context about this fictional film based on a true story. [00:05:05] Dawn asks Dom to discuss the many evidence-based applications of the ketogenic diet that he highlighted in his IHMC evening lecture. [00:07:11] Ken asks Dom about another story involving Russell Winwood, a man with severe chronic obstructive pulmonary disease, also known as COPD. Russell reached out to Dom with respect to treating his COPD with a ketogenic diet. [00:11:21] Ken asks if Russell only engaged in the ketogenic diet or if also used exogenous ketones. [00:12:10] Ken mentions that the ketogenic diet has the broad potential to be an anti-inflammatory diet. Ken goes on to mention that COPD is an inflammatory disease. As Dom's case report suggested, Ken wonders if the ketogenic diet has the potential to have strong therapeutic effects for other inflammatory conditions as well. Ken asks what other conditions Dom thinks might benefit from therapeutic ketosis. [00:14:02] Dawn mentions that Dom has been busy since his last appearance on STEM-Talk, having authored or collaborated on more than 40 papers, one of which garnered a lot of attention and was published in Frontiers in Neuroscience. This paper investigated whether therapeutic ketosis via ketone esters could represent a viable way to treat epilepsy and other seizure disorders. Dawn asks Dom to elaborate on this paper's findings and their significance. [00:16:26] Ken mentions that those listeners who are unfamiliar with ketone esters may want to check out our interview with Dr. Brianna Stubbs. Ken asks Dom to give a quick primer on ketone esters and why so many researchers in the field are excited about their potential. [00:19:20] Ken mentions that in addition to ketone salts and ketone esters, there are other product formulations out now, like the one from a company called Kenetik. Ken asks Dom what he thinks about this formulation. [00:23:33] Dawn mentions that Dom has had a number of animal studies published since 2019 looking at ketone induced neuroprotection and asks Dom to give an overview of some of this...

[5:41] Keto bodies and their effects on ageing[7:54] Research on ester supplementation on cyclists[19:37] Where do ketones rank as a fuel source?[26:35] Ketones and the liver[35:53] Ketones and performance[41:30] The types of ketone supplements and their brand names[1:10:09} Do ketones have protective benefits for the brain?[1:17:06] Work to improve taste and flavor[1:21:50] Research on use of ketones during heart failureFind Dr. Stubbs:TwitterAbout Dr. Stubbs:Brianna Stubbs currently works at The Buck Institute for Research on Aging. Previously, she worked at HVMN Inc, San Francisco and was a visiting academic at the Department of Physiology, Anatomy and Genetics, University of Oxford. Brianna's research focusses on the metabolism and application of exogenous ketones.

Our interview today is with Dr. Vyvyane Loh, a board-certified physician in obesity and internal medicine. She is the founder and leader of Transform Alliance for Health, a Boston preventive-care practice that  specializes in weight management and the treatment of chronic metabolic diseases such as diabetes, hypertension and dyslipidemia. She and her staff are known for helping people lose 50 pounds or more and getting their type-2 diabetic patients off their many medications. Vyvyane has spent her medical career developing expertise in immunology, metabolic syndrome, fat metabolism, clinical nutrition, and preventive medicine. In today's interview, we discuss how abdominal, or visceral, fat is linked to a wide range of metabolic disorders. Vyvyane goes on to explain how there's a clearcut association between obesity and decreased brain volume that rarely gets discussed. When her overweight patients complain about their behavior around food and how they consistently give in to snacks that patients know are bad for them, Vyvyane explains how the challenges they are facing is often a result of the brain struggling with decreased blood flow and the shrinkage of neurons. Vyvyane also shares how a patient asked Vyvyane if she knew anything about the Atkins diet, and although she didn't, Vyvyane ended up doing the diet along with her patient. This led Vyvyane to start seriously researching whether a ketogenic diet could help people not only lose weight, but also reverse chronic disease. Toward the end of today's interview, we explore Vyvyane's interest in macrophages, which are specialized cells involved in the detection and destruction of bacteria and other harmful organisms. We also have a nice discussion about how Vyvyane took some time off from practicing medicine to enroll in the writing program at Warren Wilson College in North Carolina in 1999. She spent the next two years writing a novel, “Breaking the Tongue.”  Set in Singapore during World War II, her book was nominated for the prestigious International IMPAC Award in fiction and was selected by the New York Public Library as one of its top 25 books of 2004. If you are interested in finding out more about Vyvyane, check out her website, vyvyanelohmd.com. Also, Vyvyane launched a podcast this week, which you also can find on her website. Episode one looks at “Metabolism: What It Is, And How It Affects Your Health.” If you enjoy today's interview with Vyvyane and the many other interviews we've had on STEM-Talk discussing the treatment and prevention of chronic metabolic diseases, you may want to check out the upcoming virtual conference on Targeting Metabesity. Our cohost Dr. Ken Ford will be one of nearly 70 speakers, including many former guests on STEM-Talk, talking about the growing evidence that the major chronic diseases of the day share common metabolic roots and as a result may also share common solutions. To find out more about the conference, follow this link to the Targeting Metabestiy home page where you find a program guide and list of speakers. If you would like a free ticket to the conference, click on this link where you will find instructions on how to receive a code for complimentary admission that is being offered to STEM-Talk listeners. Ken will be moderating a session on emerging research related to endogenous and exogenous ketosis in health and disease as well as the role of ketones in mild traumatic brain injury and the prevention and treatment of cancer. If you have enjoyed the interviews we've had on STEM-Talk with Drs Steven Austad, Colin Champ, James Kirkland, John Newman, Brianna Stubbs, Jeff Volek and Morley Stone, who are all speaking at the conference as well, you should find the talks by the over 70 speakers quite interesting and beneficial. So, send us an email requesting a free registration and we will make sure to send a you a code for a complimentary ticket. Show notes

"As ketone levels go up, ketones themselves inhibit their own production. When you drink an exogenous ketone and you elevate the ketones in the blood, you're going to be in the short term, blunting that fat release, that lipolysis component." Dr. Brianna Stubbs If you're an endurance athlete on the internet, there's little doubt you've stumbled across a conversation about ketogenic diets and ketone supplements, and you may have left more confused then when you arrived. That's because there are a lot of myths floating around and recommendations not based on sound evidence. I wanted to bring clarity about the differences between supplements, the data behind supplements for both performance and brain health, the required dosing to see any effect, if there is one to be found, and whether or not this is a sound investment for someone whose curiosity is peaked. To bring you reliable information, I reached out to Dr. Brianna Stubbs. Dr. Stubbs is a world expert in exogenous ketone metabolism and its implications for performance, resilience and health-span. She completed her PhD in Metabolic Physiology at the University of Oxford, and while completing her studies, she competed on the British International Rowing Team, and was a two-time World Champion lightweight athlete. Dr. Stubbs is currently Lead Translational Scientist at The Buck Institute for Research on Aging, where she's part of a team focused on developing our understanding of ketone biology, the metabolic effects of novel supplemental ketones, and their role in healthy aging. Today we dive into a lot of topics related to ketones and ketogenic diets included but not limited to: What's the difference between nutritional ketosis from a ketogenic diet and ketosis from consuming supplements. How does the body make ketones and how do ketone supplements impact that process? What dose of supplements is required to see an effect, if there is one? Why ketone supplements don't lead to increased fat burning in the way that a ketogenic diet does. The different types of ketones ($25 vs $2500!), how they differ and what the data say about each. Ketone supplements and performance in endurance sports. Ketone supplements and cognitive aspects of performance. Do ketones spare glycogen (stored carbohydrate in the muscle/liver)? Ketones, the brain, Alzheimer's and healthy aging. What are we learning? Can ketone supplements help with hypoxic exposure (altitude)? Can you consume too many ketone supplements? Imperfect Progress: How Dr. Stubbs navigates through adversity and keeps her eye on the ball when things get difficult. I would really appreciate it if you could take 1 minute right now (that's all it will take!) and head over to Imperfect Progress with Anne Guzman at Apple here, scroll down to the bottom where the comments are and give the podcast a rating out of 5 stars. This really helps me get the podcast to more people and to share this quality information with people who may be listening to everything they read on social media. I would love if you would leave a quick comment about the episode or podcast! I love sharing comments on social media and truly appreciate the feedback every time. Thank you for being a part of this learning community. To learn more from Dr. Stubbs, follow her here on twitter: https://twitter.com/BriannaStubbs.

Throughout 2021 we've had hundreds of people try out our bloodsmart.ai software within the format of our monthly group program. We've met clients from all walks of life – some athletes, some not – but most want the same things: to feel better now and to preserve healthspan later. Over the years – and especially more recently after racing was cancelled – my own goals have also shifted from athletic performance, instead landing on what needs to be done to maximise healthspan – that is the period of life spent in good health, free from the chronic diseases and disabilities of ageing. Talking each week to others with the same goals has become a highlight of my work week... On this podcast, NBT Scientific Director and coach Megan Hall and I are discussing my latest blood chemistry results and bloodsmart.ai report. I was pleased with my results a couple of years ago when my Overall Wellness Score reached a perfect 100. This time around, however, there's room for improvement, and Megan offers her usual excellent advice. If you'd like to get a blood test + a bloodsmart.ai report along with a series of group coaching sessions with Megan and me, we can arrange that for you. The coaching sessions take on a format much like this podcast, with individual reports reviewed and advice for a path forward described in detail. Be sure to follow along with this episode with Megan's detailed outline. Here's the outline of this interview with Megan Hall: [00:00:25] Podcasts featuring Brianna Stubbs, PhD: 1, 2, 3, 4. [00:02:29] Christopher Kelly's combined bloodsmart.ai report.  [00:02:58] Overall Wellness Score; Horne paper: Anderson, Jeffrey L., et al. "Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease." The American journal of cardiology 99.2 (2007): 169-174. [00:03:25] Health Assessment Questionnaire. [00:04:36] Why to get a blood test when you're feeling good. [00:12:21] Wellness Score and PhenoAge; Podcast: How to Measure Your Biological Age, with Megan Hall. [00:13:54] Individual input markers. [00:14:42] Podcasts: Why You're Probably Not Eating Enough Protein (How to Know for Sure), with Megan Hall; Protein vs. Energy for Improved Body Composition and Healthspan, with Ted Naiman, MD; Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease and How to Fight It, with Ben Bikman, PhD. [00:15:55] Protein requirements: 1.6g protein per Kg of body weight. [00:17:12] Rhonda Patrick's podcast with Ashley Mason: Dr. Ashley Mason On Drug-Free Approaches For Treating Depression, Insomnia, And Overeating | Found My Fitness With Dr. Rhonda Patrick. [00:19:44] Podcast: Blood Chemistry in Athletes, with Tommy Wood, MD, PhD. [00:21:02] Thorne Multi-Vitamin Elite. [00:21:54] Supplements Megan is most likely to take: Magnesium and creatine (with Creapure). [00:24:45] Iron panel and blood donation; DIY therapeutic phlebotomy. [00:27:17] Podcast on iron overload:  Iron overload and the impact it can have on performance and health, with Dr. Tommy Wood; “Bronze Diabetes” paper: ROOT, HOWARD F. "Insulin resistance and bronze diabetes." New England Journal of Medicine 201.5 (1929): 201-206. [00:28:46] Protein:Energy (PE) Ratio; Book: The PE Diet: Leverage your biology to achieve optimal health, by Ted Naiman. [00:38:04] Podcast: How to Go Faster and Feel More Energetic By Addressing Anaemia and Increasing Oxygen Deliverability. [00:43:25] Zinc deficiency makes RBC membranes more fragile; Study: O'Dell, Boyd L., Jimmy D. Browning, and Philip G. Reeves. "Zinc deficiency increases the osmotic fragility of rat erythrocytes." The Journal of nutrition 117.11 (1987): 1883-1889. [00:45:06] bloodsmart.ai forecasts. [00:45:45] Previous podcast talking about bloodsmart.ai and forecasts: You Literally Bled for That Data. Now What? and How to Use Biomedical Testing to Find Problems Inside Your Body. [00:50:28] Lead and toxic metals overload. [00:51:23] The negative impacts of lead on both nervous and renal systems are obvious at a blood lead concentration of 2 μg/dL; Study: Shefa, Syeda T., and Paul Héroux. "Both physiology and epidemiology support zero tolerable blood lead levels." Toxicology letters 280 (2017): 232-237. [00:53:19] Supporting detoxification. [00:55:00] Iodine and sea vegetables; Maine Coast granulated sea vegetables. [00:57:29] Summarizing action items. [00:58:01] Eat more food!  RED-S; Podcast: How to Identify and Treat Relative Energy Deficiency in Sport (RED-S), with Nicky Keay. [01:02:08] Vitamin D; Chris Masterjohn's Presentation on COVID-19 at AHS and article on Vitamin D and COVID-19: The Current State of the Evidence. [01:04:55] Megan's outline for this podcast  [01:05:11] Join a bloodsmart.ai group program to get a blood test, bloodsmart.ai report, and group coaching sessions with Megan Hall.

This week on the podcast I chat to Dr Brianna Stubbs, lead translational scientist at the Buck Institute of Ageing about exogenous ketones for health and performance. Brianna is a guru in this field and it was awesome to talk to her about her athletic career as a British under 23 rowing champion to her academic and professional career investigating ketones in both performance and now in optimal ageing. We also chat about the utility of them in recovery.Dr. Brianna Stubbs, DPhil is a world expert in exogenous ketone metabolism and its implications for performance, resilience and health-span. She completed her PhD in Metabolic Physiology at the University of Oxford, studying the metabolism and the application of exogenous ketone salts and esters. Whilst completing her studies, she competed on the British International Rowing Team, and was a two-time World Champion lightweight athlete.Brianna spent two years as Research Lead at a San Francisco based start-up called HVMN, where she helped to launch the world's first commercially available ketone ester drink and set up a collaboration with the US Special Operations Command to investigate the effects of ketone drinks on physical and cognitive performance in extreme environments.Brianna is currently Lead Translational Scientist at The Buck Institute for Research on Aging where she's part of a team focused on developing our understanding of ketone biology, the metabolic effects of novel exogenous ketones, and the translation of these findings into tools for implementation as part of a holistic approach to healthy aging.Brianna: https://www.linkedin.com/in/brianna-stubbs-91930794/Twitter:  @BriannaStubbsMikki's linkshttps://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

From world-class rower (those are the skinny boats with the fellow balanced on the end with a shouting funnel) to champion Ironman athlete, Brianna Stubbs talks with Lilias and David about her journey in to endurance sports (on land) and triathlon and her victory at Ironman Tulsa in the 30-34 age group. She had to fight for this one! Brianna's race data: https://bit.ly/3hM4to4 Support the show: bit.ly/3qsNQS3 SUBSCRIBE: iTunes: apple.co/2MLBzb2 Google: bit.ly/2xzuWhs Podcast Index: bit.ly/3gSMbRB

On today's show, Beth talks to Dr. Brianna Stubbs. Brianna is the lead translational scientist at the Buck Institute, the world’s first research institute for the study of aging. As translational scientist, she spearheads efforts to move basic science research into clinical and daily application. We hear about her research background in the applications of ketosis for health, performance and resilience, and how ketosis can be attained by ingesting a product being developed at the Buck. Executive Producer: Beth Bennett Show Producer:Beth Bennett Host: Beth Bennett Listen to the show:

➢Try Health Code's new Complete Meal, formulated by Ben Bikman, PhD Get started: https://gethlth.com use HIH to save In today's show Brianna Stubbs, PhD and others are urging us to consider novel approaches, such as dietary strategies that bolster our immune resilience. Links to research and show notes: https://bit.ly/ketones-immune-system Related Interview on ImmunoMetabolism: https://youtu.be/bucNAkg0EXA

Trey Suntrup, PhD is a product engineer who earned his doctorate in physics and electrical engineering from the University of California, Santa Barbara in 2015. He is currently the Head of Product at Readout Health, the St. Louis startup that recently launched the Biosense breath ketone meter. Following a successful clinical trial in the autumn of 2019, Biosense has entered the consumer, clinical, and research market as a tool to help those wanting to lose weight or manage blood glucose with a ketogenic diet. On this podcast, Trey discusses breath acetone testing and how it can be used to improve health outcomes. He shares the results of the clinical trial supporting the Biosense meter, including the finding that measurements must be collected multiple times daily to truly evaluate the benefit of a ketogenic or intermittent fasting plan. He also describes some of the advantages of breath testing over blood ketone measurement.  Here’s the outline of this interview with Trey Suntrup: [00:00:15] James McCarter; Podcasts: How to Reverse Insulin Resistant Type Two Diabetes in 100 Million People in Less Than 10 Years and Nutritional Ketosis and Guided Behavior Change to Reverse Type 2 Diabetes.  [00:00:20] Virta Health. [00:00:23] Douglas Hilbert; Podcast: How Busy Realtors Can Avoid Anxiety and Depression Without Prescriptions or the Help of a Doctor. [00:01:02] Trey's background. [00:04:16] NBT Podcasts on ketosis and ketones with Dominic D'Agostino, Ken Ford, Brianna Stubbs 1, 2, 3, 4; Catherine Crofts, Megan Hall. [00:04:29] Megan Hall’s Study: Roberts, Megan N., et al. "A ketogenic diet extends longevity and healthspan in adult mice." Cell metabolism 26.3 (2017): 539-546. [00:04:52] Types of ketones and methods for measuring them. [00:10:03] Study of endurance runners in ketosis: Edwards, Kate H., Bradley T. Elliott, and Cecilia M. Kitic. "Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners." Journal of Sports Sciences 38.4 (2020): 366-374. [00:11:37] Problems with measuring BHB blood ketones. [00:15:49] Deriving meaning from acetone meter results; The ACEs Unit. [00:21:49] Clinical trial: Suntrup, Donald J., et al. "Characterization of a high-resolution breath acetone meter for ketosis monitoring." medRxiv (2020). Interpretation of trial results. [00:26:15] Ken Ford on the signalling properties of ketones: STEM-Talk Podcast Episode 50: Ken Ford Talks about Ketosis, Optimizing Exercise, and the Future Direction of Science, Technology, and Culture. [00:26:26] Ketogains: Chase results, not ketones. [00:29:29] Early Time-Restricted Eating, Intermittent Fasting. Review: Mattson, Mark P., Valter D. Longo, and Michelle Harvie. "Impact of intermittent fasting on health and disease processes." Ageing research reviews 39 (2017): 46-58. [00:32:43] Biosense blog post: The Effects and Impact of Ketones and Fasting. [00:33:13] Marty Kendall’s blog post: Is the acetone:glucose ratio the Holy Grail of tracking optimal ketosis levels? [00:33:56] Continuous glucose monitors (CGM). [00:35:16] Integration with Cronometer. [00:35:48] Heads up Health; NBT podcast w/ founder David Korsunsky: How to Use Data to Take Control of Your Health. [00:38:25] Senza app. [00:40:52] Getting the biosense meter: Biosense website. [00:42:10] Upcoming clinical trials. [00:46:45] Find Trey on LinkedIn. 

Welcome to the Human Performance Outliers Podcast with hosts Dr. Shawn Baker and Zach Bitter. For this episode, Dr. Brianna Stubbs joined the show. Brianna is a ketone scientist at The Buck Institute. She completed her PhD in Metabolic Physiology at The University of Oxford. She competed for Great Britain's Rowing Team where she was a two-time World Champion.  Episode Sponsor: BiOptimizers – www.p3OM.com/humanfree Episode Sponsor: NRGCBD - https://www.nrgcbd.store/ code: EZ20 Consider supporting us: - https://www.patreon.com/HPOpodcast or https://www.paypal.me/hpopod Patreon & PayPal Supporter Raffle: https://www.altrarunning.com/ (free shoes) & https://www.sfuelsgolonger.com/ (over $100 package). Instagram handles: @shawnbaker1967, @zachbitter Twitter handles: @SBakerMD, @zbitter, @BriannaStubbs  Facebook handles: Shawn Baker, @zach.bitter Website URLs: https://zachbitter.com , https://shawn-baker.com, http://meatrx.com and https://www.buckinstitute.org/ &  https://hvmn.com/  YouTube: Zach (https://www.youtube.com/c/ZachBitterUltra) Shawn (https://www.youtube.com/channel/UC5apkKkeZQXRSDbqSalG8CQ) If you would like to set up a consult call with either Zach or Shawn, you can schedule with Zach at https://calendly.com/zbittercoaching and with Shawn at https://shawn-baker.com/consultation/ If you would like to contact the show, please send your emails to hpopodcast@gmail.com

The ability to drink your way to elevated ketone blood levels with exogenous ketones has opened a world of research about the impact of ketones on health and athletic performance. While there is still much we don't know, Dr. Brianna Stubbs is at the forefront of this research. A former world champion rower, she is now a leader in the field of ketone research. After years studying the physical performance effects of endogenous and exogenous ketones, she is now the chief scientist at the Buck Institute, where she focuses on the health and longevity implications of ketones. Can ketones make you a better athlete? Can they help you live longer? Is there a meaningful difference between a ketogenic diet and drinking exogenous ketones? These are the questions Dr. Stubbs addresses with her research. We'll explore them, and more, in this interview.

In episode 6 of Science and Chill, I interview Dr. Brianna Stubbs, a translational scientist at the Buck Institute. Dr. Stubbs earned her PhD from Oxford University in metabolic biochemistry, where she began her work on studying the effects of exogenous ketones in health and performance. She continues this work at the Buck and has published many studies on how exogenous ketone supplements might be used for athletic performance, metabolic diseases, and neurological conditions. We talk ketosis, nerd out on endurance performance, and talk about her rich history as a world-champion rower and her current interests as a triathlete. I hope you enjoy this wide-ranging conversation with a fascinating researcher! Relevant links: Follow Dr. Stubbs on Twitter @BriannaStubbs Dr. Stubbs' Wikipedia  Dr. Stubbs Research (Research Gate) Buck Institute Website 

Recently we’ve had remarkable guests on the podcast highlighting areas of evolutionary mismatch. It’s clear our society has disconnected from real food and good sleep, but we’ve also detoured from what’s optimal in how we congregate, educate, and support one another. We’ve divided ourselves into nuclear families, often leaving our children in the care of strangers so we can go to a job we don’t care about, in order to earn money to pay for our segregated lifestyle. Social isolation has become so common we barely realize the madness of it - until we need help and find that there’s no one nearby. In this interview, I’m joined by my wife, food scientist Julie Kelly to talk about how our society could benefit from a cohousing model, transcending the current paradigm that leaves parents exhausted and young adults unable to afford housing. We discuss our own living situation and that of neighbours and friends, many of whom could benefit from living with others to share resources and skills. We’re in the contemplation stage of actually doing something about this, and would love to hear from you about experiences you’ve had - good or bad! - with cohousing or communal living.  Here’s the outline of this interview with Julie Kelly: [00:00:34] Podcast: Civilized to Death: Are We Really Making Progress? with Christopher Ryan. [00:01:07] Stephanie Welch podcasts 1. Disruptive Anthropology: An Ancestral Health Perspective on Barefooting and Male Circumcision (she discusses the concept of nuclear family at the 55:13 minute mark), 2. The Need for Tribal Living in a Modern World, focusing more exclusively on cohousing. [00:03:07] Whole 30. [00:03:52] Book: The Story of the Human Body: Evolution, Health, and Disease, by Daniel Lieberman. [00:05:08] Book: Lifespan: Why We Age―and Why We Don't Have To by David A. Sinclair, PhD. [00:05:46] STEM-Talk Podcast: Episode 98: Steven Austad talks about aging and preserving human health.   [00:05:46] Blue zone fraud; Study: Newman, Saul Justin. "Supercentenarians and the oldest-old are concentrated into regions with no birth certificates and short lifespans." bioRxiv (2019): 704080. [00:06:22] Book: Mothers and Others: The Evolutionary Origins of Mutual Understanding, by Sarah Blaffer Hrdy. [00:07:08] Alloparents. [00:13:00] Attachment theory. [00:26:42] Podcast: How to Optimise Your Gut Microbiome, with Lucy Mailing. [00:30:59] Book: Delivering Happiness: A Path to Profits, Passion, and Purpose, by Tony Hsieh. [00:33:40] Podcast on unschooling: How to Support Childhood Cognitive Development, with Josh Turknett, MD. [00:36:00] Podcast: How to Live Well in a High Tech World, with Cal Newport. [00:37:31] Strategies and tactics of cohousing. [00:39:45] Contact me if you have experience with cohousing: chris@nourishbalancethrive.com. [00:42:30] Patreon; Forum thread on cohousing. [00:42:48] Cohousing resources: Why Denmark dominates the World Happiness Report rankings year after year; Pocket Neighborhoods; The New Generation of Self-Created Utopias; My working cohousing Google doc. [00:43:15] Podcast: A Statin Nation: Damaging Millions in a Brave New Post-health World, with Malcolm Kendrick. [00:47:19] Starcity. [00:49:56] Grandmother hypothesis. [00:54:05] Cooperative breeding. [00:58:07] Book: Mindset: The New Psychology of Success by Carol Dweck. [00:58:12] Book: Radical candor: Be a Kick-Ass Boss Without Losing Your Humanity, by Kim Scott. [01:01:08] Book: Chop Wood Carry Water: How to Fall in Love with the Process of Becoming Great, by Joshua Medcalf. [01:01:39] Podcast: Ketones for Performance, Cognition, and Cardiovascular Health, with Brianna Stubbs, PhD. [01:03:18] Book: The Evolution of Everything: How New Ideas Emerge, by Matt Ridley. [01:06:05] Podcast: Building Compassionate Communities to Improve Public Health, with Julian Abel, MD.

Researcher and elite athlete Brianna Stubbs is back on the podcast today, checking in before her recent Ironman competition in Santa Cruz, California. Since we last talked with Brianna she’s left HVMN and joined the Buck Institute for Research on Aging as Lead Translational Scientist. There she’ll be studying ketone biology and collaborating on some of the best research being conducted today with the mission of living better, longer. In this interview, Brianna and I talk about some of the latest studies on ketone metabolism, which continues to show promise for athletic performance, cognition, and cardiovascular health. She also notes where the research in this area is lacking and even contradictory. Brianna also shares her personal strategy for dosing the ketone monoester she helped bring to the marketplace.  Here’s the outline of this interview with Brianna Stubbs: [00:00:00] Brianna’s previous podcasts: World Champion Rower and Ketone Monoester Researcher Brianna Stubbs, The D-BHB Ketone Monoester Is Here, Women in Science: Bridging the Gender Gap, and The Latest Research on Exogenous Ketones and Other Performance Enhancers. [00:02:00] Racing Ironman. [00:05:10] Lesley Paterson; Podcast: Off Road Triathlon World Champion Lesley Paterson on FMT and Solving Mental Conundrums. [00:06:57] Dosing the ketone ester during the triathlon. [00:09:55] Ketone ester as a tool to to evaluate perception of exercise; Study: Faull, Olivia Kate, et al. "Beyond RPE: The perception of exercise under normal and ketotic conditions." Frontiers in physiology 10 (2019): 229.  [00:11:09] Lead Translational Scientist at the Buck Institute for Research on Aging. [00:13:01] Dale Bredesen, MD; Eric Verdin, MD. [00:13:36] Review on ketone metabolism: Newman, John C., and Eric Verdin. "Ketone bodies as signaling metabolites." Trends in Endocrinology & Metabolism 25.1 (2014): 42-52. [00:14:56] Jeff Volek, PhD, RD & Stephen Phinney, MD, PhD [00:18:07] STEM-Talk Podcast: Episode 92 with Megan Roberts and Episode 94 with John Newman. [00:19:27] β-Hydroxybutyrate (BHB), as an endogenous histone deacetylase inhibitor; Study: Shimazu, Tadahiro, et al. "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor." Science 339.6116 (2013): 211-214. [00:21:42] HVMN. [00:22:59] Epigenetic effects of ketones. [00:27:27] BHB can affect vascular senescence; Study: Han, Young-min, et al. "β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4." Molecular cell 71.6 (2018): 1064-1078. [00:30:24] BHB inactivates the NLRP3 inflammasome; Study: Youm, Yun-Hee, et al. "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease." Nature medicine 21.3 (2015): 263. [00:31:02] BHB protects against muscle protein wasting; Study: Thomsen, Henrik H., et al. "Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies." The American journal of clinical nutrition 108.4 (2018): 857-867. [00:32:11] Increased inflammatory response with ketone ester; Study: Neudorf, Helena, et al. "Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes." Molecular nutrition & food research (2019): 1801171. [00:35:52] Ketogenic diet and exogenous ketones reduce epileptiform spikes associated with Alzheimer’s: Newman, John C., et al. "Ketogenic diet or BHB improves epileptiform spikes, memory, survival in Alzheimer's model." bioRxiv (2017): 136226. [00:36:51] Kenneth Ford, PhD.; Podcast: Optimal Diet and Movement for Healthspan, Amplified Intelligence and More with Ken Ford [00:37:57] Cardiovascular effects of ketone infusions in humans; Studies: 1. Nielsen, Roni, et al. "Cardiovascular effects of treatment with the ketone body 3-hydroxybutyrate in chronic heart failure patients." Circulation 139.18 (2019): 2129-2141. 2. Gormsen, Lars C., et al. "Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study." Journal of the American Heart Association 6.3 (2017): e005066. [00:38:06] Ketone infusions in a paced model of cardiac failure in dogs. Study: Horton, Julie L., et al. "The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense." JCI insight 4.4 (2019). [00:43:05] Ketogenic diet and gut health. [00:44:31] Exogenous ketones affect stem cell regeneration and differentiation; Study: Cheng, Chia-Wei, et al. "Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet." Cell 178.5 (2019): 1115-1131. (We don’t have access to the Supplementary Methods, which contain Brianna’s favorite molecule!) [00:46:02] Performance enhancing effects of lactate/propionate: Scheiman, Jonathan, et al. "Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism." Nature Medicine (2019): 1. [00:47:22] Lucy Mailing; Podcast: How to Optimise Your Gut Microbiome. [00:50:24] Improved performance with the ketone monoester; Study: Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell metabolism 24.2 (2016): 256-268.  [00:50:30] No performance benefit with ketone monoester supplement; Study: Evans, Mark, et al. "No Benefit of Ingestion of a Ketone Monoester Supplement on 10-km Running Performance." Medicine and science in sports and exercise 51.12 (2019): 2506-2515. [00:52:00] Dr. Stephen Cunnane’s studies correlating blood ketone level and changing cognitive function and brain ketone uptake: Cunnane, Stephen C., et al. "Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of Alzheimer’s disease." Frontiers in molecular neuroscience 9 (2016): 53; 2. Fortier, Mélanie, et al. "A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment." Alzheimer's & Dementia 15.5 (2019): 625-634. [00:52:40] Breath ketone meters. [00:57:03] Find Brianna on Twitter.

FITTER RADIO COFFEE CLUB FREE RACE ENTRY COMPETITION: (00:09:53) IRONMAN 70.3 Geelong. For more details go to our website at https://www.fitter.co.nz/join-us WORKOUT OF THE WEEK: (00:15:15) Nike Vaporflys - ban them or embrace the new technology. Bevan and Mikki discuss the controversy around these new trainers. HOT PROPERTY INTERVIEW: BRIANNA STUBBS (00:24:33) Brianna Stubbs is a world expert in ketone metabolism and consults with elite sport, military, clinical and research organizations. We talk to Brianna, now Lead Translational Scientist for the Buck Institute, about exogenous ketones and the endurance athlete. ONE STEP AHEAD (01:33:41) The humble potato. LINKS: IRONMAN 70.3 Geelong at https://www.ironman.com/triathlon/events/asiapac/ironman-70.3/geelong.aspx#axzz64B61519O More about Brianna Stubbs and her research at https://hvmn.com/team/brianna-stubbs The Buck Institute for Research on Aging at https://www.buckinstitute.org/ Pilates for Sports link on our page at https://www.fitter.co.nz/about-radio Training Peaks link on our page at https://www.fitter.co.nz/about-radio The Potato study at https://sci-hub.se/10.1152/japplphysiol.00567.2019 CONTACT US: Learn more about us at http://www.fitter.co.nz   Like us on Facebook at http://www.facebook.com/fittercoaching for the latest news and information Mikki Williden can be found at https://www.facebook.com/mikkiwillidennutrition

At the 2019 Ancestral Health Symposium, I managed to catch up with metabolism and fitness expert Mike T. Nelson, PhD. Mike was there presenting on a subject that many in the health space find both intriguing and confusing: cannabinoids and CBD. Really, who amongst us hasn’t wondered if using CBD will get us in hot water at the next work-related drug screening? And is it even legal? On this podcast, Mike demystifies the terms bantered about when it comes to the cannabis plant.  What exactly is the difference between hemp, THC, and CBD anyway? He cuts through the marketing hype and talks about the specific health conditions that respond best to cannabidiol (CBD). He also shares exactly how he uses it to prevent brain injury during extreme sports. Here’s the outline of this interview with Mike T. Nelson: [00:00:11] Mike’s Ancestral Health Symposium 2019 talk: Mike Nelson - CBD and Cannabinoids: Beneficial Plant Compounds or All Hype? - AHS19. [00:02:30] Charlotte's Web cannabidiol (CBD). [00:03:33] FDA warning letters to CBD companies. [00:03:43] Mislabeled CBD products (low CBD, high THC); Study: Freedman, Daniel A., and Anup D. Patel. "Inadequate Regulation Contributes to Mislabeled Online Cannabidiol Products." Pediatric neurology briefs 32 (2018): 3-3. [00:04:06] Getting terms straight: Cannabis, hemp, CBD, THC, marijuana, and others. [00:04:30] Cannabis found in 2700 year old grave in ancient China. Study: Russo, Ethan B., et al. "Phytochemical and genetic analyses of ancient cannabis from Central Asia." Journal of experimental botany 59.15 (2008): 4171-4182. [00:09:40] Leonhart Fuchs cultivated cannabis sativa in 1542. [00:09:52] Difficulty in differentiating between Sativa, Indica, and hybrid strains; Study: Schwabe, Anna L., and Mitchell E. McGlaughlin. "Genetic tools weed out misconceptions of strain reliability in Cannabis sativa: Implications for a budding industry." Journal of Cannabis Research 1.1 (2019): 3. [00:13:20] Entourage effect; Study: Ben-Shabat, Shimon, et al. "An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity." European journal of pharmacology 353.1 (1998): 23-31. [00:15:36] THC use associated with survival after traumatic brain injury (TBI); Nguyen, Brian M., et al. "Effect of marijuana use on outcomes in traumatic brain injury." The American Surgeon 80.10 (2014): 979-983. [00:16:48] Animal studies support the use of cannabinoids for TBI: Maroon, Joseph, and Jeff Bost. "Review of the neurological benefits of phytocannabinoids." Surgical neurology international 9 (2018). [00:17:55] CBD has a cerebroprotective effect; Study: Khaksar, Sepideh, and Mohammad Reza Bigdeli. "Intra-cerebral cannabidiol infusion-induced neuroprotection is partly associated with the TNF-α/TNFR1/NF-кB pathway in transient focal cerebral ischaemia." Brain injury 31.13-14 (2017): 1932-1943. [00:19:11] Mike's pre-kiteboarding supplement regimen; Cerebroprotective effects of creatine; Study: Sullivan, Patrick G., et al. "Dietary supplement creatine protects against traumatic brain injury." Annals of neurology 48.5 (2000): 723-729. [00:21:46] Pros and cons of CBD use. Safety: 1. Ahmed, Amir IA, et al. "Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: a randomized controlled trial." European Neuropsychopharmacology 24.9 (2014): 1475-1482; 2. van den Elsen, Geke AH, et al. "Efficacy and safety of medical cannabinoids in older subjects: a systematic review." Ageing research reviews 14 (2014): 56-64. [00:23:36] Cost of 300mg of Charlotte’s Web CBD Oil per day = $7.50/day. [00:25:06] Rescuing energy metabolism in the brain; Podcast: The Latest Research on Exogenous Ketones and Other Performance Enhancers, with Brianna Stubbs, PhD. [00:29:08] Effects of cannabidiol on cortisol; Study: Zuardi, A. W., F. S. Guimaraes, and A. C. Moreira. "Effect of cannabidiol on plasma prolactin, growth hormone and cortisol in human volunteers." Brazilian journal of medical and biological research= Revista brasileira de pesquisas medicas e biologicas 26.2 (1993): 213-217. [00:31:19] CBD and sleep; Review of clinical trials: Kuhathasan, Nirushi, et al. "The use of cannabinoids for sleep: A critical review on clinical trials." Experimental and clinical psychopharmacology (2019). [00:33:04] Top 3 potential uses for CBD: Sleep, head trauma, pain. [00:35:10] THC and CBD for pain. [00:37:01] Grasshopper for vaping tools.  [00:37:28] CBD oils. [00:38:03] Vaping less harmful than cigarettes; Studies: 1. McNeill, Ann, et al. "Evidence review of e-cigarettes and heated tobacco products 2018." A report commissioned by Public Health England. London: Public Health England 6 (2018), 2. Walele, Tanvir, et al. "Evaluation of the safety profile of an electronic vapour product used for two years by smokers in a real-life setting." Regulatory toxicology and pharmacology 92 (2018): 226-238. [00:40:30] CBD in beverages. [00:42:26] Will CBD get you busted at work? THC amount might be much higher than the label indicates; Study: Freedman, Daniel A., and Anup D. Patel. "Inadequate Regulation Contributes to Mislabeled Online Cannabidiol Products." Pediatric neurology briefs 32 (2018): 3-3. [00:47:03] CBD as an ergogenic aid. Review: Jorm, Anthony F., et al. "Gender differences in cognitive abilities: The mediating role of health state and health habits." Intelligence 32.1 (2004): 7-23. [00:48:13] State-dependent memory. [00:50:11] Work with Mike: www.miketnelson.com. Flex Diet Certification.

Our former Research Lead, Dr. Brianna Stubbs, played an essential role bringing ketone esters to the public for the very first time. Brianna is now helping further ketone research at the Buck Institute, and we couldn't be more excited to follow her future work. We dedicate this special episode to her experience in the trenches here at H.V.M.N. In this episode, we cover: · Reminiscing about the exciting projects, tough obstacles, and amusing moments spanning Brianna's time on the team · How Brianna reacted and dealt with the initial community perception of H.V.M.N. Ketone · The balancing act of relentlessly working to become the best human one can be without losing touch with what it means to be human · The future of ketones (whether endogenously or exogenously) for general health, medical, & sport application p.s. This isn't a good-bye forever...rest assured Brianna will be returning every so often! ----------------------------------------------------------------- Check out our products for optimal metabolic, physical, & cognitive health: https://www.hvmn.com/pod Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.

Life on the road can be good, bad and ugly - and Bobby and Gus dig into it all on this episode. We talk seedy hotel rooms and even seedier Tour roommates. There’s cold pasta, mosquitoes, ants under the sheets and some too-close-for-comfort body contact. The legendary Jens Voigt pops in, and he is bummed out about George Bennett losing so much time on stage 10. 
And special guest Dr. Brianna Stubbs explains Ketones and their use in the peloton. It’s time to Put Your Socks On.

Life on the road can be good, bad and ugly - and Bobby and Gus dig into it all on this episode. We talk seedy hotel rooms and even seedier Tour roommates. There’s cold pasta, mosquitoes, ants under the sheets and some too-close-for-comfort body contact. The legendary Jens Voigt pops in, and he is bummed out about George Bennett losing so much time on stage 10. 
And special guest Dr. Brianna Stubbs explains Ketones and their use in the peloton. It’s time to Put Your Socks On.

The broad field of nutrition and health is rife with myths, misconceptions and frequently posed yet seemingly fundamental questions that we intuitively feel should have simple answers. Is a calorie a calorie? Is obesity due to eating too much or doing too little? Is breakfast actually the most important meal of the day? When looking through the lens of insulin resistance, breakfast has often been seen as a "problem" meal that leads to the largest blood sugar spikes...especially for Type 2 diabetics. This is largely due to the typical "healthy" Western breakfast foods that are high in carbohydrates: Cereal, oatmeal, toast and fruit. A recent study aimed to explore if eating a low-carb and high-fat meal first thing in the morning is a simple way to prevent this large insulin spike, improve glycemic control throughout the day, and reduce other diabetes complications. This is the paper Dr. Brianna Stubbs will be diving into in this episode of the Research Roundup. Referenced Study: https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqy261/5435774?redirectedFrom=fulltext ---------------------------------------------------------------------------- Check out HVMN's products for optimal metabolic health: https://www.hvmn.com/pod Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.

Back on the podcast today, we have researcher and athlete Brianna Stubbs, PhD. Brianna has been a world-champion rower and is now competing in cycling, running, and triathlon. She is also Research Lead for HVMN, advancing the science on human optimisation and creating content and products to improve physiology, metabolism, and cognition. As a world expert on ketone metabolism, Brianna is here with me to talk about the latest research on exogenous ketones. We discuss their effects on athletic performance, brain injury, and cognition, and she weighs in on the controversy regarding the effect of ketone esters on the inflammasome. We also look at the misunderstood role of lactate and how it’s now being used to improve athletic performance. Here’s the outline of this interview with Brianna Stubbs: [00:00:35] Our previous podcasts with Brianna: 1, 2, 3. [00:02:00] Podcast: Professor Tim Noakes: True Hydration and the Power of Low-Carb, High-Fat Diets. [00:02:19] Andrew Bosch at the University of Cape Town. [00:05:03] Training for full Ironman. [00:05:19] Podcast: Off Road Triathlon World Champion Lesley Paterson on FMT and Solving Mental Conundrums. [00:07:39] Using ketone esters to fuel for a race. [00:10:18] Who's using the ketone ester? [00:11:08] Effects of ketone esters on cognitive function; Study: Evans, Mark, and Brendan Egan. "Intermittent Running and Cognitive Performance after Ketone Ester Ingestion." Medicine and science in sports and exercise 50.11 (2018): 2330-2338. [00:12:21] Rescue of ATP in the brain of mice given exogenous ketones; Study: Prins, M. L., et al. "Increased cerebral uptake and oxidation of exogenous βHB improves ATP following traumatic brain injury in adult rats." Journal of neurochemistry 90.3 (2004): 666-672. [00:13:46] Unpublished research on ketone esters in hypoxia: Ketone Esters for Optimization of Cognitive Performance in Hypoxia. [00:15:33] One hour cycling record; Vittoria Bussi. [00:16:00] Bradley Wiggins; The Flying Scotsman Graeme Obree; Jens Voigt. [00:19:19] Professor Tim Noakes; Central governor model of fatigue: Noakes, Timothy D. "The central governor model of exercise regulation applied to the marathon." Sports medicine 37.4-5 (2007): 374-377. [00:19:32] Cyclists go slower from the first pedal stroke when you put them in a hot laboratory; Study: Tucker, Ross, et al. "The rate of heat storage mediates an anticipatory reduction in exercise intensity during cycling at a fixed rating of perceived exertion." The Journal of physiology 574.3 (2006): 905-915. [00:19:43] Cold water in mouth reduces perceived effort and improves performance. Study: Burdon, Catriona A., et al. "The effect of ice slushy ingestion and mouthwash on thermoregulation and endurance performance in the heat." International journal of sport nutrition and exercise metabolism 23.5 (2013): 458-469. [00:19:57] Cooling mouthwash improves performance; Study: Jeffries, Owen, Matthew Goldsmith, and Mark Waldron. "L-Menthol mouth rinse or ice slurry ingestion during the latter stages of exercise in the heat provide a novel stimulus to enhance performance despite elevation in mean body temperature." European journal of applied physiology 118.11 (2018): 2435-2442. [00:22:25] Podcast: Science and Application of High Intensity Interval Training with Paul Laursen, PhD. [00:22:56] Potential therapeutic applications of ketone esters. [00:23:43] Ketogenic diet may help with alcohol withdrawal. Study: Dencker, Ditte, et al. "Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats." Alcoholism: Clinical and Experimental Research42.2 (2018): 270-277. [00:24:43] Dr. Stephen Cunnane; MCT study: Courchesne-Loyer, Alexandre, et al. "Emulsification increases the acute ketogenic effect and bioavailability of medium-chain triglycerides in humans: protein, carbohydrate, and fat metabolism." Current developments in nutrition 1.7 (2017): e000851. [00:28:13] Ketone esters as nootropics. [00:30:23] Mitigating traumatic brain injury (TBI); lactate. [00:31:41] Improved outcomes with lactate infusion in intensive care; Study: Nalos, Marek, et al. "Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial." Critical care 18.2 (2014): R48; and Ichai, Carole, et al. "Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial." Intensive care medicine 39.8 (2013): 1413-1422. [00:32:22] Professor George Brooks; Study: Thomas, Claire, et al. "Effects of acute and chronic exercise on sarcolemmal MCT1 and MCT4 contents in human skeletal muscles: current status." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302.1 (2011): R1-R14. [00:33:07] Ketones: the ugly duckling of metabolism. Study: VanItallie, Theodore B., and Thomas H. Nufert. "Ketones: metabolism's ugly duckling." Nutrition Reviews 61.10 (2003): 327-341. [00:34:20] Podcast: Why Cholesterol Levels Have No Effect on Cardiovascular Disease (And Things to Think about Instead), with Dr. Malcolm Kendrick. [00:35:28] Lactate increase carbohydrate usage and improves performance; Study: Azevedo Jr, John L., et al. "Lactate, fructose and glucose oxidation profiles in sports drinks and the effect on exercise performance." PLoS One 2.9 (2007): e927. [00:37:24] Cytomax, Muscle Milk. [00:39:11] L-Lactate vs D-Lactate; D-lactate free probiotics. [00:40:01] Podcast: How to Use Probiotics to Improve Your Health, with Jason Hawrelak, PhD. [00:40:44] Butyrate and exogenous ketones; Study: Cavaleri, Franco, and Emran Bashar. "Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health." Journal of nutrition and metabolism 2018 (2018). [00:41:21] Effect of patents on innovation. [00:42:34] Richard Stallman, president of the Free Software Foundation. [00:44:10] Paper recently accepted for journal publication on GI symptoms associated with ketone esters (not yet published). [00:44:53] Acetoacetate diester causing GI symptoms; Study: Leckey, Jill J., et al. "Ketone diester ingestion impairs time-trial performance in professional cyclists." Frontiers in physiology 8 (2017): 806. [00:49:45] Study: Dearlove, David James, et al. "Nutritional ketoacidosis during incremental exercise in healthy athletes." Frontiers in physiology 10 (2019): 290. [00:51:21] Dominick D’Agostino, PhD; β-hydroxybutyrate (BHB) blocks inflammation; Study: Youm, Yun-Hee, et al. "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease." Nature medicine 21.3 (2015): 263.   [00:52:32] Newer study showing greater inflammatory response with ketone ester: Neudorf, Helena, et al. "Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes." Molecular nutrition & food research(2019): 1801171. [00:53:46] Denmark study on effect of ketones on LPS-induced inflammation: Thomsen, Henrik H., et al. "Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies." The American journal of clinical nutrition 108.4 (2018): 857-867. [00:59:32] How to find Brianna and HVMN: Twitter: @BriannaStubbs and @HVMN; Instagram: HVMN; Website: hvmn.com; HVMN blog. [01:00:00] HVMN podcast on Apple Podcasts;  HVMN on YouTube.

Michael Brandt, who co-founded HVMN along with our main host Geoffrey Woo, just came back from running the 2019 Boston Marathon. Especially with Boston being Michael’s second ever marathon, everyone on the HVMN team was impressed & extremely happy to hear of his 2:48 finish time. A sub 3-hour marathon is not an easy feat. On average, Michael was completing each mile in 6 minutes and 24 minutes...for 26 miles straight. Dr. Brianna Stubbs sits down with Michael to delve into his training structure and the running tips he’s picked up, his experience running the mother of marathons, and what motivates him to run nearly every day. ---------------------------------------------------------------------------- Visit HVMN: https://www.hvmn.com/pod Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.

Can you be a high level athlete while eating a ketogenic diet? Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Brianna Stubbs. Brianna has a PhD in Metabolic Physiology from the University of Oxford and she was a professional rower for the rowing team of Great Britain. She’s a two time champion at the World Rowing Championships. Currently, she’s the leading researcher at HVMN, which is a company that produces performance supplements for the ketogenic diet. Brianna welcome to the show. Timestamps: How Brianna Got Into Researching Ketosis 02:30 How Long Does It Take to Become Keto Adapted 12:45 What Sports Benefit From the Ketogenic Diet 19:40 Can Power Athletes Use Keto 28:22 Effects of Exogenous Ketones on Performance 33:50 Difference Between Ketone Salts and Esters 38:20 What Brianna Eats When Training for an Ironman 52:27   And much more... Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon If you want to support this podcast, then I'd greatly appreciate if you could join my Patreon community. You'll be able to get access to unique worksheets about Body Mind Empowerment, a lot of exclusive videos about my routines, biohacking workshops, and a privilege for your questions on the next Q&A.  Click Here to Support the Show on Patreon!   Show Notes My NEW BOOK Metabolic Autophagy Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Use the Code SIIM for a 10% discount on BluBlox Glasses Use the Code redsiim at Redlightrising.co.uk Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program   P.S. The HD video recordings of all the Biohacker Summit Tallinn speeches are now released. Incredible information about optimizing your health and well-being. My own speech talks about doing fasting with training for longevity and muscle growth. Check it out!    Stay Empowered Siim  

Wait...hasn't ketones been shown to reduce inflammation in prior studies? When a new study researched the effects ketones have on inflammation, the results were opposite to what everyone expected...including the researchers themselves. The paper was published in the Journal of Molecular Nutrition and Food Research, and the research group that carried out the work were led by Dr Jonathan Little at the University of British Columbia. Rather than inhibiting the inflammatory response through BHB’s (a ketone body) actions on the NLRP3 inflammasome, the researchers found that activity of several immune markers was higher when people had consumed ketones. It can be easy to jump to conclusions and state that "Exogenous Ketones = Increased Inflammation"...as the title of the paper acutely suggests. Dr. Brianna Stubbs tackles this study and provides further, necessary nuance on how the experiment was conducted, why the results may actually be more positive than negative, and why this development warrants future research. Referenced Studies: 1. https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201801171 2. https://www.ncbi.nlm.nih.gov/pubmed/30239561 ---------------------------------------------------------------------------- SAVE 50% OFF GO CUBES: https://www.hvmn.com/pod (offer ends April 19th, 2019) Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.

On this Research Roundup, Dr. Brianna Stubbs discusses the culprit behind a news story that generated a health controversy recently. What do you think the media touted as the next food ready to knock years off your life? This time it’s not cakes and soda, it's not red meat, it's not alcohol...it’s the humble egg. Dr. Brianna Stubbs unpacks the study behind the batch of fear-mongering headlines. The study in question was published in a well respected journal called JAMA. The study is titled: Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality. After discussing the controversial JAMA study, Dr. Brianna references two additional papers to help paint a more balanced picture around egg consumption: Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies. Eggs enriched in omega-3 fatty acids and alterations in lipid concentrations in plasma and lipoproteins and in blood pressure. What's the truth about eggs? Tune in and find out!   ---------------------------------------------------------------------------- Visit HVMN: https://www.hvmn.com/pod Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.

Hello listeners, and welcome to the HVMN Podcast. It’s Dr. Brianna Stubbs. We’re switching things up here this week, as I’ll be your host...giving Geoff a bit of time off! This week, we are going to look at the topic of Science communication. If you’ve tuned in to my Research Roundup series, which can get quite science-heavy at times, you may find that it can be tough to follow along with the medical terms and jargon. And honestly, it can be challenging for me to break down these complicated topics and make them interesting and accessible for people who have different levels of background science knowledge. When thinking about the ‘art and science’ of communication, with science you might need to go even more towards the art - to try and bridge the gap between research and public understanding. This has always been a pain point. With the inescapable rise of social media and the big uptick in numbers of scientists and influencers in health and performance who are taking to Twitter to share their findings and thoughts, science communication has changed a lot in the last few years. It will surely continue to evolve. I explore this hefty topic with Dr. Paige Jarreau, whose research focuses on the intersection of science communication, journalism, and new media. Along with teaching at LSU, she works at LifeOmic, a telemedicine app we touch upon in this episode. Page also practices some of Team HVMN’s favorite interventions, such as intermittent fasting and meditation. We chat about science on social media, tips for beginners on reading research papers, and some of the challenges women face in academia.   --------------------------------------------------------- Check us out: www.hvmn.com/pod  Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit. 

Welcome to the HVMN Research Round Up, hosted by Dr. Brianna Stubbs. Today, we’ll be going down one of Brianna's personal favorite rabbit holes: The way that ketones from the ketogenic diet and exogenous ketone affect inflammation. Is the ketogenic diet as a whole responsible for the reduction of inflammation? Or is it the specific ketone body BHB (beta hydroxybutyrate) that has the most impact? This is a major question that Brianna brings up and explores in this episode. We’ll go through three studies on this topic, where Brianna will walk you through the research process, discuss and analyze the results, and muse over the potential implications. Referenced Studies: 1. https://www.ncbi.nlm.nih.gov/pubmed/18046594 2. https://www.ncbi.nlm.nih.gov/pubmed/25686106 3. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211005   --------------------------------------------------------- Our listeners are eligible for an exclusive HVMN website discount, updated monthly: www.hvmn.com/pod  Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit. 

Dr. Brianna Stubbs (@BriannaStubbs) has a PhD in ketone metabolism from the University of Oxford and is the research lead at HVMN, a ketone ester drink and nootropics company in San Francisco. Brianna is also world-champion rower who won two gold medals for Great Britain in the lightweight women's double and quadruple sculls, as well as winning the Oxford-Cambridge boat race twice. She's the youngest person to row across the English channel at age 12.   Dr. Brianna and I discuss the following: Her background and what led her to study ketone metabolism Her athletic achievements & how they tie in Her work with athletes today How ketones can impact athletic performance How ketogenic benefits vary by sports Ketone effects on health and cognition Where Brianna sees the world of ketones and the keto diet headed Who should be worried about ketones vs. not Carnivore diet and ketones What Brianna's diet and exercise regime look like today Her role at HVMN Her goals going forward   Where to find out more about Dr. Brianna and follow her: Twitter HMVN ketones esters HMVN podcast   What questions would you like answered or who would you like to hear from in the carnivore or research community?   Let me know on Twitter, Instagram, and Facebook. You can also email me at info@carnivorecast.com.

I turned 30 a few weeks ago on Dec 27. Two weeks before, I decided to do something pro-active to celebrate. I decided to run 30 miles. It was an aggressive goal given that the longest I’ve ever run was a half-marathon (just 13.1 miles). I was going to do more than double with less than two weeks to train. But..was it truly insane? I’ve interviewed world record-breaking athletes, Olympians, former Navy SEALS, and ultra marathon champions on this program. I’ve seen numerous examples of people achieving the impossible. The arbitrary milestone of 30 years of not dying seemed like a good excuse to see how far I could push myself. I’m proud to say I did it, and I believe all our listeners can accomplish their own version of my 30-mile challenge. This time around, our co-host Dr. Brianna Stubbs sits in the interviewer chair, diving into my two-week “training”, what was going through my mind as the miles passed by, and what I’ve learned from the experience. ------------------------------------------------------------------------------ Our listeners are eligible for an exclusive HVMN website discount, updated monthly: www.hvmn.com/pod  Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit. 

Our Research Lead, Dr. Brianna Stubbs, tends to read a lot of scientific literature...a lot. In this episode of Research Roundup, Dr. Stubbs dives into three papers studying the effects of diet (plant-based, animal-based, & ketogenic) & intermittent fasting on the gut microbiome. 1. Diet rapidly and reproducibly alters the human gut microbiome 2. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet 3. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota ------------------------------------------------------------------------------ You are eligible for an exclusive HVMN website discount, updated monthly: www.hvmn.com/pod  Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit.   

To stay up to date on the cutting-edge of health and performance, HVMN Research Lead Dr. Brianna Stubbs tends to read a lot of scientific literature...a lot. Every month, she will dive into the latest and most exciting research papers by walking us through the experiment process, dissecting the results and implications, and candidly share her own thoughts on the study and subject as a whole. This month, Dr. Stubbs dives into three studies relating to the topic of intermittent fasting. Featured researchers include Dr. Jason Fung, Dr. Valter Longo, Dr. Courtney Peterson. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes ------------------------------------------------------------------------------ Visit our website to learn more: www.hvmn.com/pod  Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you $15 worth of HVMN Store Credit. 

The most commonly asked questions about ketone esters, answered. From inquiries directly from our community, Geoff and Dr. Brianna Stubbs clear the misconceptions, talk data, and explore both proven and potential applications of HVMN Ketone. In this episode, we answer: How can a non-athlete use ketone esters? Would it be beneficial for someone who is fasting or following the ketogenic diet? Why not just eat more carbs for athletic performance? Why add ketones? Can ketone esters be helpful for diseases such as Alzheimer's and Diabetes?  Save $50 off a 12-pack of HVMN Ketone: https://go.hvmn.com/podcast-offer Offer ends November 30th, 2018. ---------------------------------------------------------------------------- Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you a one-month's supply of Kado (https://go.hvmn.com/kado-podcast).

Emerging research on the effects of the main circulating ketone body BHB (beta-hydroxybutyrate)on inflammation is becoming more relevant to COPD (chronic obstructive pulmonary disease. In this episode I talk to leading ketone researcher Dr Brianna Stubbs about how BHB may be a potential tool for respiratory patients. Brianna is the research lead at HVMN, the first company to bring a ketone ester to market.

Emerging research on the effects of the main circulating ketone body BHB (beta-hydroxybutyrate)on inflammation is becoming more relevant to COPD (chronic obstructive pulmonary disease. In this episode I talk to leading ketone researcher Dr Brianna Stubbs about how BHB may be a potential tool for respiratory patients. Brianna is the research lead at HVMN, the first company to bring a ketone ester to market.

Science, technology, engineering and mathematics (STEM) - It’s a group of academic disciplines and professions that have historically been male-dominated. In 2017, women held 47% of all jobs in the US, but only 24% of STEM jobs. As a result, we are lacking the perspectives of women in fields that contribute heavily to our progress as a society. On the podcast today, NBT Scientific Director Megan Roberts is talking with Elizabeth Nance, PhD, and Brianna Stubbs, PhD, scientists leading teams of researchers in the areas of biotechnology and physiology. The trio talk about the unique aspects of being women in scientific fields, including the importance of allies and mentors, imposter syndrome, and identifying your own biases. Here’s the outline of this interview with Elizabeth Nance and Brianna Stubbs: [00:00:23] Elizabeth's STEM-Talk podcast. [00:00:49] Previous podcasts: Elizabeth: Nanotechnology: The Big Impact of Tiny Particles; Brianna: World Champion Rower and Ketone Monoester Researcher Brianna Stubbs; The D-BHB Ketone Monoester Is Here. [00:01:08] HVMN. [00:03:01] Science, technology, engineering, and mathematics (STEM). [00:09:50] Positive Discrimination [00:12:59] Nature vs nurture; causes of women’s underrepresentation in science. Studies: Ceci, Stephen J., and Wendy M. Williams. "Understanding current causes of women's underrepresentation in science." Proceedings of the National Academy of Sciences (2011): 201014871, and Cheryan, Sapna, et al. "Why are some STEM fields more gender balanced than others?." Psychological Bulletin 143.1 (2017): 1. [00:15:57] Freakonomics Podcast: What Can Uber Teach Us About the Gender Pay Gap? [00:18:36] Chemical engineering: 30% women. [00:21:57] Mentorship. [00:22:53] Prof. Kieran Clarke, University of Oxford. [00:23:36] #MeToo Movement. [00:24:28] Allies in the workplace. [00:25:25] Service to the department. [00:29:00] Diversity and mentorship. [00:31:01] Fluid mentor/mentee roles and boundaries. [00:34:05] Women in Chemical Engineering. [00:37:37] Gender differences in mentoring. [00:40:44] Work-life balance. [00:47:02] Judgment and criticism from others. [00:50:29] Parenting. [00:56:44] Letting the work speak for itself vs. focusing on minority status. [01:00:22] Book: Whistling Vivaldi: How Stereotypes Affect Us and What We Can Do (Issues of Our Time), by Claude M. Steele. [01:00:26] Self-fulfilling effect of stereotypes. [01:05:35] Imposter syndrome. [01:12:15] Embracing failure. [01:14:27] University of Washington Resilience Lab. [01:17:15] Being a catalyst for progress. [01:17:17] Conscious use of language. Article: Letters of recommendation for women more likely to raise doubts. [01:25:52] Defining success. [01:28:36] Brene Brown Ted Talks: The Power of Vulnerability and Listening to Shame. [01:29:04] Book: How Successful Women Think: It's All In The Mind, by Latrell King. [01:30:00] Additional articles: 1. These labs are remarkably diverse — here’s why they’re winning at science; 2. 4 Ways Women Can Build Relationships When They Feel Excluded at Work; 3. The uncomfortable question powerful women should answer; 4. Where Women Must Defy the Odds to Become Scientists; 5. These are the 10 best and worst states for women.

There are a variety of exogenous ketone products on the market today, many of which are consumed by athletes and people looking for a natural source of energy to increase their endurance and physical performance. Most of these products, however, have to be consumed in relatively large volumes and have high quantities of artificial sweeteners. That's not the case with HVMN Ketone--the world's first ketone ester sports drink shown to increase endurance, athletic performance, and cognitive ability.  Brianna Stubbs, Ph.D., is a research lead at HVMN Ketone and joins the podcast today to discuss the difference between the ketone salt products that have been on the market and the ketone ester used in the HVMN Ketone drink, and why ketone esters are far superior to ketone salts. By virtue of the fact that ketone esters are more potent than ketone salts, the drink can be consumed as a quick shot, rather than an unpalatable 16 ounces of liquid filled with artificial sweetener and a salty undertaste.  Research on the benefits of ketone esters and the ketogenic diet, in general, has shown that beyond the ability to improve cognitive and physical performance, increased ketones in the body can boost brain metabolism and slow or prevent the progression of cognitive deficits such as Alzheimer's.   Interested in learning more or trying it for yourself? Tune in and visit hvmn.com.

Welcome to the first episode of our brand-new monthly series: Research Round-up. To stay up to date on the cutting-edge of health and performance, our HVMN Research Lead Dr. Brianna Stubbs tends to read a lot of scientific literature...A LOT. In fact, she wants to share all this stored up knowledge with you: Our podcast listeners. Every month, she will dive into the latest, most relevant, and exciting research papers. It's tough to get through a written study, and that's why Dr. Stubbs is here to walk us through the experiment process, dissect the results and implications, and candidly share her own thoughts on the paper and subject as a whole.  This month, Dr. Stubbs dives into three papers, all relating to the topic of aging and longevity: BHB Prevents Vascular Senescence Through hnRNP A1-Mediated Upregulation of Oct4 Quantitative Analysis of NAD Synthesis-Breakdown Fluxes Young Blood Reverses Age-Related Impairments in Cognitive Function and Synaptic Plasticity in Mice ------------------------------------------------------------------------------ Visit our website to learn more: https://go.hvmn.com/podcast-audio Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you a one-month's supply of Kado (https://go.hvmn.com/kado-podcast).

The quest to get Shaun's around the Frankfurt Marathon in under 2hours 20mins continues! We talk about his race win at a wet and windy trail race on Dartmoor, and his lack of recovery since then. We also start thinking about race day nutrition and discuss the ketone drink HVMN with elite rower and Research Lead, Brianna Stubbs. Could it prevent Shaun's dicky belly during the race and propel him under the 2.20 barrier? We also discuss how you can physically join in with the training...if you live in the London area. If you like this episode please SUBSCRIBE to get every episode delivered to you before everyone else.  Join the conversation! If you want to join in, request a guest or chat about this episode then head over to the Strava Group (https://www.strava.com/clubs/144083) Follow us on Twitter (https://twitter.com/letsgetrunning) | Instagram (https://www.instagram.com/letsgetrunning/) | Email us | Buy merch at the shop. (https://www.letsgetrunning.co.uk/shop?category=Running+Clothing) Lastly, don't forget to rate and review on iTunes! (https://itunes.apple.com/gb/podcast/lets-get-running-podcast/id1392963885?mt=2&app=podcast)  

The Sunday Times’ tech correspondent Danny Fortson brings on Geoff Woo and Dr Brianna Stubbs of HVMN, developer of a synthetic ketone drink to “optimise humans,” to talk about Woo's his early days tinkering “nootropics” (3:30), experimenting on himself (7:10), tapping the biobacker community (10:00), getting investment from Silicon Valley A-listers (11:30), the Pentagon’s super-solder programme “Metabolic Dominance” (14:30), ketones and ketogenic diets (15:55), turning ketone ester into a product (22:15), how fasting led to the creation of the company (24:20), how Brianna Stubbs’ became the youngest person to row the English Channel (28:20), trying the first ketone “space milkshake” (30:30), the early days when ketones costs thousands of pounds per drink (33:10), meeting Woo (34:50), who is using it today (38:45), raising $7m from sports and tech investors (40:30), and my totally unscientific ketone test (42:30). See acast.com/privacy for privacy and opt-out information.

The Tour de France is a tense, three-week long cycling race between a total of 176 riders covering more than 2,000 miles. It truly is one of the greatest athletic tests in all of sports. There’s a great deal of history here, with this year being the 105th race. With any world-class competition that spans decades, you end up seeing continued innovation to not only keep up with the times, but also to push the limits of competitors. The Tour de France is a textbook example of this. In this episode of the HVMN podcast, Dr. Brianna Stubbs will be giving you all a glimpse of the physical, software, and nutritional innovations that transformed the race into what it is today. ------------------------------------------------------------------------------ Take a short survey that will help us improve the podcast and be entered in a HVMN Ketone giveaway: https://go.hvmn.com/podcastsurvey We also want to hear from our listeners/viewers! Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you a free Sprint Mini.

In Season 2 Episode 18, Dr. Bubbs “rewinds” the tape and revisits key insights and expert tips from the past two seasons. In part 1 of this episode, guests Dr. Shawn Arent, Dr. Eric Helms and Isabel Lahela talk body composition measurement techniques, the nuances of carbs for hypertrophy and weight loss, and the interference effect of HIIT training on bodybuilders. In part 2, Dr. Brianna Stubbs, Dr. Susan Kleiner and Dr. Jose Antonio will discuss supplements for sport, such as exogenous ketones, carbs, beetroot juice and HMB. In part 3, Dr. Stavros Kavouras and Prof Tim Noakes will outline different hydration strategies for athletes and the general population. And finally, in part 4 Dr. Fergus Connolly, Dr. Jeremy Koenig and Olympian Heather Moyse will talk emotions and mindset in sport, the “warrior gene” and how to overcome your own fears, assumptions and roadblocks. Make sure to check out show notes and all past episodes at drbubbs.com/podcast.

If you had one hour to teach a friend all about ketosis, press the play button and sit back. In previous conversations, host Geoffrey Woo has touched on many aspects of ketosis: The research that has been done, the metabolic pathways that are activated, how burning fat for energy affects physical performance, and the different interventions used to reach a state of ketosis. This episode acts as the source of truth. Geoff and Dr. Brianna Stubbs sit down to lay down the fundamentals, look back at the history, and ponder over what the future will bring.  In this discussion, you will discover: The difference between being in a state of "ketosis" and being "ketogenic" How to properly implement a ketogenic diet and the common mistakes many make The specific metabolic processes your body undergoes to use ketones for the body and mind     We want to hear from you. Contact podcast@hvmn.com with any feedback, questions, and guest suggestions! Write a review for us on iTunes, let us know via email, and we'll send you a free Sprint Mini.

It's time to switch things around! In this special episode, HVMN Research Lead Dr. Brianna Stubbs is put on the hot seat as Peter Bowes interviews her about biohacking, ketone supplementation, and moving to another country to work at a growing start-up. Original episode description below: Brianna Stubbs has been a competitive athlete all her life. At the age of 12, in 2004, she became the youngest person to row across the English Channel. She went on to win a gold medal with the GB Rowing Team at the 2016 World Rowing Championships and twice rowed for Oxford in the Women’s Boat Race against Cambridge. Alongside her athletic endeavors, Brianna pursued an academic career, completing her PhD in metabolic biochemistry at Oxford. She is particularly interested in the effects of exogenous ketones on human performance. In this in-depth interview Brianna breaks down the theory and shares her understanding of ketone supplementation to promote physical performance. She also describes a day in the life of a semi-retired British athlete, discovering a new life and occasionally fasting in sunny California. Disclaimer: This interview is from the LLAMA Podcast by Peter Bowes. The podcast explores the science and stories behind human longevity. Check it out at http://www.llamapodcast.com/ and follow @llamapodcast!

In Season 2 Episode 8, Dr. Bubbs interviews ketone expert Dr. Brianna Stubbs PhD to discuss the impact of supplemental ketones on endurance exercise performance. In this episode, Brianna explains the differences between endogenous and exogenous ketosis, the anti-inflammatory and antioxidant effects of ketones, and the impact of ketone supplements on blood glucose and lactic acid levels, as well as endurance time-trial performance. She also discusses research on exogenous ketone effects on satiety and potential implications for weight loss. Fantastic insights here from Brianna! Check out drbubbs.com/podcast for show notes and other fantastic episodes.

Omega fatty acids, such as Omega-3 and Omega-6, has been well-known to play a crucial part in the human ecosystem. In fact, the human body can't make Omega-3's internally and must rely on foods to get it. The problem is...the majority of us aren't getting enough. Nearly 100,000 American deaths are caused by this key nutritional deficiency.  There's more to getting enough Omega fatty acids than ensuring you aren't deficient. What are the studies behind its benefits on human health, how does it travel through the system, and why does Omega-3 (rather than 6 or 9) get all the attention? Geoffrey Woo and Dr. Brianna Stubbs dive in and reveal all! If you are interested in a fish oil stack, HVMN is offering a 10% discount off our supercharged Omega-3 stack: Kado-3.  Follow or type in this link to get the discount: https://go.hvmn.com/kado3podcast   You can reach out to the producer of the podcast directly by emailing zhill@hvmn.com. Questions, guest suggestions, and feedback are all welcome!

In this episode, I talk with Dr. Brianna Stubbs (Olympic gold medalist and ketone expert) on the topic of ketone esters.  We dive into the difference between the esters and ketone salts.  We talk about racemic vs. nonracemic exogenous ketones.  We talk about the possibility of using carbs and ketones as a dual fuel.  We even cover the future of exogenous ketones!  This is a great episode and is all about the science!!!

We had a full house join our recent panel on elite human performance with Navy SEAL Admiral (ret.) Alex Krongard, Dr. Brianna Stubbs, and Michael Brandt. Thank you all for those who came! It's always humbling seeing the faces of our tight community. The variety of people at the event, from athletes to doctors to techies, all bonded over one common goal: To improve human performance in tangible and quantifiable ways.

Ketone research expert, Dr Brianna Stubbs, is today's guest interview. Brianna shares with us the the exciting news of the public commercial release of the exogenous ketone ester she has been researching for years. She helps to explain what the benefits of ketones esters are for athletic performance and when else could you drink the exogenous ketone ester. We also go into discussing other possible applications like traumatic brain injury recovery, cognitive enhancement and more. We then find out about some of the risks to watch out for and the guidance on how much to drink. Go to the show notes for episode 33 at https://www.biohackerslab.com/ep33-dr-brianna-stubbs/ for more links & highlights. Support the show.

Brianna Stubbs is a British rower and research scientist who won two gold medals for Great Britain at the 2013 and 2016 World Rowing Championships. She was the youngest person to row across the English Channel when she completed the feat in 2004, at the age of 12. Her research is focused on the metabolism of ketones.

Late in 2017, a San Francisco startup company brought one of the commercial ketone esters to market. Today’s episode features an interview with a scientist and world-class athlete who has spent the past year helping develop and rollout HVMN Ketone, an FDA-approved drink that promises increased athletic ability as well as heightened focus and energy. Dr. Brianna Stubbs earned her PhD in biochemical physiology from Oxford University in 2016 where she researched the effects of ketone drinks on elite athletes. During Brianna’s collegiate athletic career, she won two gold medals while representing Great Britain at the World Rowing Championships. She first made international news when as a 12-year-old she became the youngest person ever to row across the British Channel. Brianna graduated from Oxford’s Pembroke College with a BA in preclinical sciences with the idea of becoming an MD.  But after spending a year working as a research assistant helping to investigate the effect of exogenous ketones on human performance, she decided instead to pursue her doctorate in biochemical physiology and investigate how ketone compounds might be applied in a sporting and healthcare setting in the future. While at Oxford, she worked alongside Dr. Kieran Clarke to develop a novel ketone monoester that has been shown to improve exercise performance in endurance athletes. She also was a member of the Great Britain Rowing Team and in 2016 become the World Champion in the lightweight guadruple sculls. Brianna’s time at Oxford gave her a unique opportunity to combine her scientific interest in sports physiology and metabolism while also competing at an international level. Brianna moved to the United States in June of 2017 to work at HVMN and help bring the company’s ketone ester to market. Links: HVMN website: https://hvmn.com/ketone Mark Mattson STEM-Talk: http://www.ihmc.us/stemtalk/episode007/ Wikipedia: https://www.youtube.com/watch?v=hNhuJ4JiK40 Mice and ketones cognition: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102124/#!po=10.1064 Owen and Cahill: https://www.ncbi.nlm.nih.gov/pubmed/6061736 Oxford ketone study: https://www.ncbi.nlm.nih.gov/pubmed/27475046 Glycogen re-synthesi and ketones: https://www.ncbi.nlm.nih.gov/pubmed/28398950 Ketones, glycogen and mTOR: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440563/ Caryn Zinn: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506682/ Ketone esters vs ketone salts: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670148/ Acetoacetate paper:            https://www.frontiersin.org/articles/10.3389/fphys.2017.00806/full HVMN online fasting community: https://www.facebook.com/groups/136348456816447/ Show notes: 3:52: Ken and Dawn welcome Brianna to the show. 4:07: Dawn congratulates Brianna on bringing one of the first ketone esters to the commercial market, and asks Brianna to provide some background that led to the ketone ester launch. 5:31: Ken comments that the HBMN ester has been approved by the FDA as “generally recognized as safe,” or GRAS. He then asks her to expand on what this means in terms of human use and to expand on the value of the GRAS status. 6:31: Dawn asks Brianna what sparked her interest in science. 7:18: Ken comments that he heard Brianna was seven years old when she ran her first race, and that she ran so hard, she made herself sick. He asks if this is true. 8:16: Ken says that Brianna’s father was the one who got her interested in rowing, and when she was six years old, he signed her up for the first rowing race across the Atlantic Ocean. Ken asks if it’s true that he had never rowed before. 10:21: Dawn comments that Brianna used to run and row with her father as he trained for these races, and then when she was 12 years old she rowed across the English Channel, becoming the youngest person to ever do so. Dawn asks how this came about. 11:59: Dawn asks what Brianna’s mother was doing while she and he...

Brianna Stubbs, PhD In 2016 Brianna completed her PhD in Metabolic Biochemistry at Oxford University. She also became a World Champion rower as part of the GB Rowing Lightweight Women's four person crew, and won 3 other World Rowing Championships medals. She has published peer-reviewed studies looking at ketone metabolism, ketone ester supplementation in athletes and effects of ketones on appetite. In This Episode We Discuss: Brianna's background as an elite-level rower Her PhD research on ketone metabolism Misconceptions about ketones (both endogenous and exogenous) Ketogenesis: why do we make ketones? Brianna's study examining effect of ketone ester supplementation on appetite and ghrelin levels Who needs to even know their ketone concentration? Ketone supplements: glycogen sparing or glycogen impairing? Effect of ketone supplementation on fuel selection in endurance athletes Potential for supplementation: where is the area we will most likely see some benefit? Limitations of current literature base

Dr Brianna Stubbs is back with us today to talk about the long awaited launch of the ketone mono ester supplement that the team at Oxford University led by Prof. Kieran Clarke has been working on for the the best part of 25 years! Dr Stubbs was a previous World Rowing Champion and we discuss her experience as an elite athlete and what it take to be the best of the best. We talk about why training to be the best is not conducive to a healthy body and how the stress of training and dieting can produce real hormonal problems. Brianna has published two research papers recently on the metabolism of ketones in humans and how a ketone ester drink has shown to affect ghrellin and appetite which we discuss. The application of the new ketone ester supplement is something of much debate and we clarify the current data, uses and potential future value of the ketone esters to the public. All in all its a great way to celebrate the 100th episode of the podcast! https://twitter.com/geoffreywoo https://twitter.com/BriannaStubbs https://twitter.com/hvmn https://hvmn.com https://www.facebook.com/groups/136348456816447/about/ https://www.frontiersin.org/articles/10.3389/fphys.2017.00848/full http://onlinelibrary.wiley.com/doi/10.1002/oby.22051/full

This episode brought to you by Rock Lobster Cycles, beautiful bicycles handbuilt in Santa Cruz, California. In our last interview, scientist and world champion rower Dr Brianna Stubbs had recently successfully defended her PhD in Biochemical Physiology and reached a juncture in her career. Ten months later, Brianna has retired from professional rowing but continues her passion for biochemistry with San Francisco based nootropics company HMVN where she is working to commercialise the D-BHB ketone monoester developed at Oxford University alongside Prof. Kieran Clarke. The big news is the wait is over! After over a decade of research, the ester is finally here. This interview is two rolled into one. In the first part, we talk about Brianna’s transition out of academia and professional sport and into the world of Silicon Valley startups. In the second part, Brianna talks about the benefits of the ketone ester and takes on some of Dr Tommy Wood’s challenging questions given to me by ahead of the interview but unseen by Brianna. If you’re only interested in hearing about the ketone monoester, skip to the 24-minute mark. Here’s the outline of this interview with Brianna Stubbs, PhD: [00:01:23] Retirement from rowing. [00:02:56] Podcast: Off Road Triathlon World Champion Lesley Paterson on FMT and Solving Mental Conundrums. [00:03:19] App: Strava. [00:04:17] The move to San Francisco. [00:05:00] Professor Kieran Clarke, PhD, CEO of TdeltaS. [00:05:24] HVMN. [00:08:27] World Rowing Championships. [00:09:40] Rodent and then human experiments. [00:10:37] Finding purpose and resolving ambivalence. [00:12:09] Journaling. [00:12:55] Mentoring. [00:14:42] Podcast: How to Create Behaviour Change with Simon Marshall. [00:15:08] YouTube: HVMN Enhancement Podcast: Ep. 46: Correcting Nutritional Deficiencies ft. Christopher Kelly. [00:15:38] Tony Hsieh of Zappos.com. [00:16:38] Body composition. [00:17:39] BHRT (Bioidentical Hormone Replacement Therapy). Podcast: The Critical Role of Oestradiol for Women’s Cognition with Dr. Ann Hathaway, MD. [00:17:57] DXA scan. [00:18:09] Intermittent fasting. [00:19:22] We Fast Facebook Community. [00:20:42] Put on 20lb, mostly muscle. [00:24:51] Podcast: World Champion Rower and Ketone Monoester Researcher Brianna Stubbs. [00:25:19] Dr. Richard Veech, Hans Krebs. [00:26:52] Ketone metabolism. [00:28:04] Study: Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell metabolism 24.2 (2016): 256-268. [00:28:47] Case Report: Newport, Mary T., et al. "A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease." Alzheimer's & Dementia 11.1 (2015): 99-103. [00:29:20] FDA GRAS (generally recognized as safe). [00:29:32] WADA. [00:30:38] Who is the ester for? [00:31:54] Article and Studies: Reference 1, 2 and 3. [00:33:30] Glycogen sparing or impairing? [00:35:57] WINGATE test. [00:36:08] If you've got ketones, you don't break down as much protein? BCAA. [00:36:32] Study: Vandoorne, Tijs, et al. "Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle." Frontiers in physiology 8 (2017). [00:37:27] Pro cycling. [00:39:00] Study: Youm, Yun-Hee, et al. "The ketone metabolite [beta]-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." Nature medicine 21.3 (2015): 263-269. [00:40:05] Why is glucose required for an increase in exercise performance? [00:41:12] Anaplaerosis. See Tommy’s letter published recently in the journal Strength and Conditioning. [00:42:19] Should we stop using the salts? [00:42:41] Appetite suppressing effects of ketones. [00:43:02] D and L isomers. [00:44:11] Dominic D'Agostino, PhD. [00:45:14] Are diet and lifestyle still the most important factors? [00:46:36] Caffeine, nitrates, beta-alanine. [00:47:31] Ketone ester 30 min rowing performance. [00:49:21] Podcast: SNR #195: Brendan Egan, PhD – Exogenous Ketone Supplementation. [00:52:25] Study: Volek, Jeff S., et al. "Metabolic characteristics of keto-adapted ultra-endurance runners." Metabolism 65.3 (2016): 100-110. [00:52:41] Intramuscular triglycerides. [00:53:07] Ketones as signaling molecule. [00:53:46] YouTube: HDAC inhibitors and Podcast: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice with Megan Hall. [00:54:27] Nicotinic acid receptor. [00:55:11] Book: Behave: The Biology of Humans at Our Best and Worst by Robert M. Sapolsky. [00:56:16] General anesthesia. [00:57:11] Two papers, Kieran hyperglycemia and Veech (ask Tommy) [00:59:02] Exogenous ketones lower blood glucose. [00:59:46] Biden pancreatic islet study [01:00:26] Insulin is anti-proteolytic. [01:00:37] George Cahill paper [01:03:03] Who's it for? [01:03:12] Price. [01:04:06] Intestinal Alk Phos. See Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More with Dr. Tommy Wood. [01:06:12] Product page at HVMN.

Brianna Stubbs (@BriannaStubbs) has been a competitive athlete all her life. At the age of 12, in 2004, she became the youngest person to row across the English Channel. She went on to win a gold medal with the GB Rowing Team at the 2016 World Rowing Championships and twice rowed for Oxford in the Women’s Boat Race against Cambridge. Alongside her athletic endeavors, Brianna pursued an academic career, completing her PhD in metabolic biochemistry at Oxford. She is particularly interested in the effects of exogenous ketones on human performance. Earlier this year she joined the San Francisco biohacking company HVMN to pursue her research into the science of human enhancement. In this in-depth interview Brianna breaks down the theory and shares her understanding of ketone supplementation to promote physical performance. She also describes a day in the life of a semi-retired British athlete, discovering a new life and occasionally fasting in sunny California.

Episode 19: Brianna Stubbs- Human (HVMN) - Ketosis & Nootropics    This week on the Game of Life we are taking a trip into the future and get the first behind the scenes look on what will literally change the sports performance and training world both from a physical and mental standpoint. And we will give you the sneak peak on what is to come in terms of Human evaluation. Yeah this podcast is earth shattering. Seriously. What the internet did for communication, this company is doing for human development.  We are diving in depth on everything Ketosis and how the first Ketone Ester will make athletes and people in all walks of life who use if feel like Ironman, we'll talk about what Nootropics is and how much of a positive impact it can have on mental clarity, focus, and overall brain functionality.  Basically, this is like the Jetson's meets professional sports, meets becoming a superhero. The information you are about to learn from Brianna Stubbs of HVMN, youngest person to row across the British Channel, former World Champion for the British National rowing team, has a PHD at Oxford University, and about every other accolade you could imagine, will blow your mind. You are about to learn information to take to your life, your daily routines, your diet, the way you approach personal daily life improvement that could literally change your life.  All coming at you only here on The Game of Life   ---------------------------------------   Sponsor: Whoop  ---https://whoop.com/ CODE: TGL    10% OFF ($50 off!!!) Train like a pro - track your sleep and know EXACTLY what level of recovery you are at when you wake. Either you are able to attack the day or it's a rest day. Whoop will let you know   ---------------------------------------   3 Pts of the Week:   1. Book I'm Reading Relentless - Tim Grover https://www.amazon.com/Relentless-Unstoppable-Tim-S-Grover/dp/1476714207 Fore more than two decades, legendary trainer Tim Grover has taken the greats—Michael Jordan, Kobe Bryant, Dwayne Wade, and dozens more—and made them greater. Now, for the first time ever, he reveals what it takes to get those results, showing you how to be relentless and achieve whatever you desire.   2. Self Improvement of the Week Transcendental Meditation -  All positive effects from TM - http://www.livestrong.com/article/520586-transcendental-meditation-effects/ https://en.wikipedia.org/wiki/Transcendental_Meditation   3. Behind the Scenes in the NBA (Westbrook training videos only if they sign up for the newsletter) If you go to dnabasketball.com and opt in to be part of the family you are going to see first hand the MVP of the NBA training in the off season. And let me tell you, there is no 'off day' or 'relax' button in this guys system. What you see on the floor in the games - the most dynamic player in the NBA in arguablely the past 25 years, is the same way on the court in the offseason. Just like the book by Grover - Westbrook is Relentless. And if you opt in to the DNA - David Nurse Academy newsletter at dnabasketball.com you will get the Westbrook training video firsthand, and not to mention super cool weekly info that you can ONLY get as being part of the family.     Follow everything HVMN -- https://hvmn.com   Twitter:  Brianna Stubbs: @BriannaStubbs HVMN: @hvmn Geoffrey Woo (CEO): @geoffreywoo   ------------------------------------------ Call in of the WEEK! (This week the call in came from an NBA Scout!)   Send me any feedback at IG - davidnurse5 Twitter - davidnurse05 Email - davidnurse5@gmail.com   AND BE ENTERED TO WIN NBA TICKETS OF YOUR CHOICE!!!    

Welcome to the THINKING Podcast, produced by HVMN.  Episode 34 features Geoffrey Woo returning to the mic with Brianna Stubbs, who is now formally a member of the growing HVMN team. Dr. Stubbs, coming from an impressive academic and athletic background, is leading our Research and Development team in our efforts to contribute to the space of human enhancement.  Geoff and Dr. Stubbs discuss the differences between industry-funded research and government-funded research, not shying away from the uncomfortable truths and nature of any funded study. Dr. Stubbs dives into the difficulties scientists have including women into a study, in which standardizing is a challenging process due to constantly changing variables (i.e hormones) that are present in women. Geoff also ponders about the role of science and research development in the world of top-tier athletics, in which Brianna reveals that it is tough to convince elite athletes to partake in any experiment, likening them to a well-oiled machine in which any outside variable can throw them off their track. Needless to say, the research world is a complicated beast. Luckily, we have one of the best researchers to make certain that HVMN has integrity around searching for the truth, while also having a sustainable business model that will continue to serve you all with the products you've come to know and love (plus more in the future)! Check out HVMN: https://hvmn.com/?utm_source=podcast&utm_medium=post

Welcome to Part 2 of Episode 25 of the THINKING Podcast! Geoff sits down with Brianna Stubbs, a British rower who has achieved numerous accomplishments, including being the youngest person ever to cross the English Channel in a rowing boat...at age 12. Not only is Brianna a full-time athlete who won Great Britain a gold medal at the 2016 World Rowing Championships, but she also studied rigorously at the prestigious Oxford University. She went on to become a respected researcher in the space of ketones, an alternate energy source for our bodies that burns fat instead of glucose. Geoff and Brianna discuss her athletic and academic background, where Brianna shares how she managed her formidable lifestyle. She once was finishing up a science lab at school when she remembered it was the time she was supposed to be at the gym. Instead of giving up and standing by idly, she started doing squats in the middle of the class whilst monitoring a rat heart. Now that's dedication!

Brianna Stubbs joins us today to talk about her work at Oxford University with ketone esters and her view on the benefits form both a sports performance and healthcare perspective. We talk about her career as a GB Team Rower, her Gold Medal at the 2016 World Rowing Championships and how she came to be the youngest person to row the across the English Channel at the age of 12 years old! Check out Brianna on Twitter: https://twitter.com/BriannaStubbs 

Welcome to Part 1 of Episode 25 of the THINKING Podcast! Geoff sits down with Brianna Stubbs, a British rower who has achieved numerous accomplishments, including being the youngest person ever to cross the English Channel in a rowing boat...at age 12. Not only is Brianna a full-time athlete who won Great Britain a gold medal at the 2016 World Rowing Championships, but she also studied rigorously at the prestigious Oxford University. She went on to become a respected researcher in the space of ketones, an alternate energy source for our bodies that burns fat instead of glucose.  Geoff and Brianna discuss her athletic and academic background, where Brianna shares how she managed her formidable lifestyle. She once was finishing up a science lab at school when she remembered it was the time she was supposed to be at the gym. Instead of giving up and standing by idly, she started doing squats in the middle of the class whilst monitoring a rat heart. Now that's dedication!

Brianna Stubbs, PhD is an extraordinary woman on multiple levels. She was the youngest person ever to row across the English Channel, has represented GB at every age level and won gold at the World U23 Championships in 2013, and again at the senior level at the 2016 World Championships. Brianna will be looking to build on that success during the Tokyo 2020 Olympiad. If that wasn’t enough, Brianna recently gained her PhD in Biochemical Physiology at Oxford University where she worked alongside Dr Kieran Clarke to develop a novel ketone monoester that has recently been shown to improve exercise performance in endurance athletes. You should listen to this podcast to discover the special benefits of ketones and their supplementation. Here’s the outline of this interview with Brianna Stubbs, PhD: [00:01:10] Early rowing days. [00:02:10] Different types of athlete: rowing versus sculling. [00:03:14] Rowing training is mostly endurance, but the races are short. [00:05:00] 24 mMol/L blood lactate! [00:05:25] When Propel Coaching tested my lactate threshold I topped out at a measly 7.8. [00:06:18] Lactate clearance. [00:07:20] The road to medical school. [00:08:52] Kieran Clarke, PhD. [00:10:03] Juggling training and academic work. [00:12:19] Working on the ketone monoester. [00:12:39] Instant Ketosis: 0.4 to 6.2mM in 30 Minutes. [00:12:49] Ketone salts. [00:13:22] How ketone supplements improve athletic performance. [00:14:39] Ketones spare protein. [00:15:09] What type of events stand to benefit. [00:16:37] Sweet spot 2-4 mM? [00:17:16] Stellingwerff, Trent[Author] ? Ref [00:18:14] Palatability and tolerability. [00:20:11] What level of athlete stands to benefit? [00:21:29] 2% cycling performance over a 1h TT. See Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268. [00:23:16] Diet vs supplements. [00:24:22] Interview with Mike T. Nelson: High Ketones and Carbs at the Same Time? Great Performance Tip or Horrible Idea… [00:24:36] Monocarboxylate transporter. [00:25:36] Randle cycle. [00:27:32] Ketosis implies a bias towards fat! [00:28:19] High glucose and ketones. [00:28:38] Exogenous ketones lower glucose. [00:29:42] Each person may be different. [00:29:59] Applications outside of sports performance. [00:31:48] Ketone supplements for weight loss. [00:32:14] Gibson, A. A., et al. "Do ketogenic diets really suppress appetite? A systematic review and meta‐analysis." obesity reviews 16.1 (2015): 64-76. And Paoli, Antonio, et al. "Ketosis, ketogenic diet and food intake control: a complex relationship." (2015). [00:33:07] Suppressed ghrelin. [00:35:02] Plans for the future. [00:36:23] Dominic D'Agostino. Lots of good interviews recently, including SNR #164: Dominic D’Agostino, PhD – Press-Pulse Model of Cancer Therapy, Ketones & Metabolic Drugs. [00:36:38] Volek J[Author] & Phinney SD[Author]. [00:36:54] PHAT FIBRE study (in press). [00:39:59] The Precision Xtra meter by Abbott measures only the physiological D-BHB. [00:41:10] Mass spectrometry chiral analysis. [00:41:49] Podcast: The Race to Make a Ketone Supplement, See Lincoln, Beth C., Christine Des Rosiers, and Henri Brunengraber. "Metabolism of S-3-hydroxybutyrate in the perfused rat liver." Archives of biochemistry and biophysics 259.1 (1987): 149-156. [00:42:13] Hsu, Wei-Yu, et al. "Enantioselective determination of 3-hydroxybutyrate in the tissues of normal and streptozotocin-induced diabetic rats of different ages." Journal of Chromatography B 879.29 (2011): 3331-3336. And Tsai, Yih-Chiao, et al. "Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes." Life sciences 78.12 (2006): 1385-1391. [00:46:39] Book: The Case Against Sugar by Gary Taubes. [00:47:14] Chris Masterjohn exchanging nutritional bogeymen. [00:48:32] Availability of the ketone monoester. [00:49:22] Brianna Stubbs (@BriannaStubbs) on Twitter.