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The Milk Minute Podcast- Breastfeeding/Chestfeeding/Lactating/Pumping
Ep. 79- Alcove Baby Update- Lyra is 6-months!

The Milk Minute Podcast- Breastfeeding/Chestfeeding/Lactating/Pumping

Play Episode Listen Later Oct 15, 2021 55:38


Starting solids, a killer bee-attack, and milk supply issues... a 6-month update on baby Lyra!Maureen tells all when it comes to her newly 6-month-old kiddo. The alcove baby is growing up

The Andrew Price Podcast
#17: Dylan Ekren - Making Good Characters

The Andrew Price Podcast

Play Episode Listen Later Oct 15, 2021 102:43


Chat with Dylan Ekren who currently works as a CG character designer at Netflix. Previous to that he worked at Disney making characters for Wreck it Ralph, Zootopia, Frozen, Big Hero 6 and the upcoming Encanto movie. In this long ranging discussion, we cover: 0:00 - Intro 1:55 - Getting into art 7:49 - Good learning resources 25:01 - What separates out successful artists from the rest 31:07 - Efficient use of time 42:42 - Learning path for new artists 57:53 - Dylan's Career after college 1:19:20 - Moving to Netflix Animation 1:25:30 - Dylan's favourite artists

Nialler9
PinkPantheress, James Blake & the "new nostalgic"

Nialler9

Play Episode Listen Later Oct 14, 2021 55:18


This week's Nialler9 podcast with Niall and Andrea, is inspired by the sharp rise of London producer PinkPantheress and her sampling garage, drum & bass and pop music of the 2000s-era, which she has labelled the "new nostalgic". I referenced a book last week, in our conversation with Jenn Gannon, Simon Reynolds' 2011 book  Retromania: Pop Culture's Addiction to Its Own Past. Retromania argues that retro revives a past that is barely over and does so with a prevalent mood of postmodern irony. Interestingly, what has happened in the last ten years is an increase in earnestness and almost wholesale dropping of irony, while new artists have continued to copy, sample and draw influence from existing music, the current generation of Gen Z's shifting priorities and attention to important facts and issues in society, marks a sea change in sensibilities. The ironic detachment of the hipster era has been superseded by a mantra of caring - expressions of truth and desire and meaning over bored detachment or non-commitment. PinkPantheress' music brings up ideas about how older generations gatekeep music, and how women and men sampling classic music is viewed differently, how Tik Tok and a lifetime of internet culture has freed younger artists to express themselves cross-genre and how being a bedroom pop artist is now a phenomenon of relatability rather than a trend of style. We also talk about the parallels between PinkPantheress and James Blake who first arrived sampling the likes of Kelis and Aaliyah, and whose electronic music went on to influence the mainstream, as Blake's own music, as heard on the just released Friends That Break Your Heart, has moved increasingly earnest itself. Listen to the episode below or Subscribe in your favourite podcast app: Subscribe in Apple | Android | ACAST | Pocketcasts | CastBox | Stitcher | Spotify | RSS Feed Songs played on the Nialler9 Podcast Spotify Playlist Andrea has a new podcast - My Favourite Album Support Nialler9 on Patreon and join our Discord chat + member playlists and content. Andrea has a Ghost newsletter Subscribe to the podcast and please leave a review on iTunes, tell your friends or commit to supporting us directly. Support us on Patreon. Previous podcast episodes

Mindful Multi Family Show
Mindful Multi Family Show #179 with Chris Salerno(Mastering RV Parks with Greg Scully and Darren Light)

Mindful Multi Family Show

Play Episode Listen Later Oct 13, 2021 31:48


Greg Scully Greg is a former small business owner and retired from a 20 year career with Frito-Lay.  Since 2016 he has invested passively in 50 units in Beech Grove Indiana and has had an active ownership role in 204 units split between Chattanooga, Johnson City and Knoxville Tennessee.  The combined market value of these properties is approximately $12,800,000.00. Previous real estate investing included single family homes in Memphis and a small residential development project in South Carolina.   Darren Light Darren has been investing in real estate full time for 2 ½ years, 3 years total. He started by purchasing single family rental homes and doing flips. He quickly realized that multifamily was a much simpler and faster way to create wealth. He has been a general partner in 204 units combined in Knoxville. Johnson City, and Chattanooga, Tennessee. He also has 6 flip homes in various stages for 2019. He is local to the area, having grown up in Oak Ridge, and wishes to employ a buy and hold strategy in multifamily, especially in the local area.   If you like what you hear please leave us a review so we can help add value to other people.  If you like what you hear be sure to like, share, subscribe! Podcast- Mindful Multi-Family show Instagram- Chris_Salerno_ Youtube Channel- Chris Salerno Like, subscribe, share, and comment below!

Holistic Christian Life - Worshiping God - Mind, Body, Soul
You Are An Icon of Christ with Fr. John Vlahos - Ep.132

Holistic Christian Life - Worshiping God - Mind, Body, Soul

Play Episode Listen Later Oct 12, 2021 35:36


Cynthia talks with Fr. John Vlahos today about how we, as living icons, should be relating to others.  What does this look like?  In a world full of judgement and friction, we can be vessels of love...spreading the love and grace of God to others put in our path.  Let us as Christians be the example.  Today we talk about how. Fr. John was born and raised in Merrillville, Indiana. He received a Bachelor's Degree in Public Financial Management from Indiana University in 1997 and his Masters of Divinity Degree in 2001 from Holy Cross Greek Orthodox School of Theology in Brookline, Massachusetts. Fr. John is married to Presvytera Tina and they have two daughters (19 years old and 12 years old). Fr. John comes to us with over 19 years of experience as a clergymen of the Greek Orthodox Archdiocese. He joined the St. Paraskevi Community in Greenlawn, NY in October 2020. Prior to joining there, Fr. John was the Dean of the Archdiocesan Cathedral of the Holy Trinity in NYC from 2014 to 2020. Previous to that, he was the priest of the Church of the Holy Resurrection in Brookville, New York from 2008-2014 and the Associate Priest of St. Paul's Cathedral in Hempstead, New York from 2006-2008. He began his ordained ministry as a Deacon to Archbishop Demetrios of America from 2002-2006. Is it time to make some changes in your life? Do you want to stop the madness and get on track with your health? Maybe coaching is right for you. I've helped many people gain their health back over the years, and would love to talk with you. Just reach out with the link below to get on my schedule. From time to time I have openings for new clients and accept them on a first come first serve basis. Book a Discovery Call

Real Life Real Crime
Not True part 2

Real Life Real Crime

Play Episode Listen Later Oct 12, 2021 56:56


In this episode, Woody concludes a story from his career about a rape and the details that follow. Real Life Real Crime is proudly sponsored by: This week: Athena Club: (Ad @ 24:59) Show your skin you care with the Athena Club Razor Kit! Sign up today and you'll get 20% off your first order! Just go to AthenaClub.com and use promo code rlrc. Wondery (Ad at 40:52) ZocDoc : (AD at 13:35) Sign up for free today! Never wait on hold for a receptionist again! Previous weeks: Canva: Design like a pro with Canva Pro! Right now, you can get a FREE 45-day extended trial when you use my promo code! Just go to canva.me/rlrc to get your FREE 45-day extended trial. Everyplate: Get started with EveryPlate for just $1.99 per meal by going to EveryPlate.com entering code rlrc199 Talkspace Start feeling better with a single message- Match with a licensed therapist when you click the link and get $100 off your first month with the promo code REALCRIME _____________________________________________________________________________________________________________ We ask for the continued support of the Coco family as they go through this next chapter. We ask that you continue to call in tips about Barbara Blount @225-395-1302 or use the TIP button on Real Life Real Crime, the app. Want more episodes? Download our app in the app store or Google Play and listen straight from the app! Follow us on: INSTAGRAM: @REALLIFEREALCRIME, @OVERTONWOODY Twitter: @reallifecrime Contact us: For Business Inquiries ONLY, please contact cyndi@realliferealcrime.com Real Life Real Crime proudly supports: LOPA- Woody Overton is a huge supporter of LOPA. Just listen to his podcast and you will hear him mention it at the end of each episode. Please take the time to click the LOPA link and REGISTER. It takes 2 minutes and just 1 donor can save up to 8 LIVES! Real Life Real Crime held a raffle which raised over $8,000 for LOPA in a few short weeks. The raffle was sponsored by Duvalle's Cajun Charters, Jim Chapman, Local Leaders: The podcast, Tiffany Sicard of HomeKey Mortgage and Real Life Real Crime. We all look forward to this years raffle that will be amazing! Our goal is to double last years number! Merakey Gateway is near and dear to Real Life Real Crime. This transition service provides comprehensive transition training for individuals diagnosed with autism and related orders as they transition into a life of greater independence. Their programs work with the individual to identify personal goals and create a plan to accomplish their dreams. Whether an individual wants to get a job, go to college, or just become more independent, the Gateway team can assist with an individualized pathway to success. The transition plan will include skills related to employment, community life, housing, finances and independent living. Gateway Ink is a social enterprise screen printing business which trains and employs participants as they learn vocational skills. Their Shop Manager and Program Director work together in developing individual training techniques and identifying accommodation needs for the participant to bring into their future careers. Orders placed through Gateway Ink, support our programming financially as well as provide a job for our participants looking to build their skills and reach their goals Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

CTStartup Podcast
Episode 137: Revisiting A Previous Guest and Civility on Social Media

CTStartup Podcast

Play Episode Listen Later Oct 11, 2021 57:12


CTStartup has been around for quite some time now, and we have talked with many guests who have done many great things. One of our first guests, Matt Cremins, has returned to CTStartup with a new idea on how to bring civility back to social media with his partner Keith Fox and their startup, CivilTalk.

The Gary Null Show
The Gary Null Show - 10.11.21

The Gary Null Show

Play Episode Listen Later Oct 11, 2021 58:37


Can low temperature-aged garlic enhance exercise performance? Korea Univesity & National Institute of Agricultural Sciences (South Korea), October 8, 2021 Scientists from South Korea's National Institute of Agricultural Sciences and Korea University looked at aged garlic to see whether it could help reduce fatigue. To do this, they conducted a study on mice fed with a special low-temperature-aged garlic (LTAG). Their findings were published in the Journal of Medicinal Food. Testing the fatigue-fighting effects of low temperature-aged garlic The researchers chose to use LTAG because it lacked the pungent odor and spicy flavor of regular garlic, making it easier to use for animal testing. To create the LTAG, the researchers stored garlic in a sealed container, aging at 60 C for 60 days. The resulting LTAG was then peeled and pulverized, before being added to 200 milliliters of 70 percent ethanol (EtOH), which was then subjected to ultrasonic extraction three times. This 70 percent EtOH and LTAG extract was then concentrated under a vacuum at 45 C and then lyophilized to create a dry LTAG residue. After the creation of the LTAG, the researchers then separated mice into six groups. The first group was given a low dose of LTAG extract; the second was fed a high dose of LTAG extract; the third was given a low dose of garlic extract; and the fourth was given a high dose of garlic extract. The fifth and sixth groups consisted of normal mice that were given phosphate-buffered saline (PBS) instead of garlic. One of these control groups was made to exercise while the other group was not. The mice in the five groups were forced to run on a treadmill for four weeks. With each passing week, the amount of exercise the mice would have to do on the treadmills would increase. This was done by increasing both the speed that the mice had to run, and the amount of time they had to spend running. (Related: How to alleviate fatigue with herbal medicine.) After 28 days of treatment, five mice from each group were subjected to a final, exhaustive treadmill test. This test increased the treadmill speed from 15 meters per minute (m/min) to 40 m/min every 3 minutes. During this test, the running time was monitored until each mouse failed to follow the increase in speed on three consecutive occasions and lag occurred. At this point, the mouse's total running time was recorded. The effect of the LTAG on the levels of glucose, lactate dehydrogenase (LDH), free fatty acid (FFA) and lactate in the mice's blood. Following the final exercise, the mice were killed and blood samples were collected from them. In addition, the mice's gastrocnemius muscles were also isolated and frozen in liquid nitrogen for testing. LTAG treated mice demonstrated less fatigue Following the exhaustive running tests, the researchers found that the mice treated with LTAG extract were able to run for much longer than the control mice. Meanwhile, looking at the blood tests, they noted that the mice treated with LTAG extract exhibited lower levels of glucose, LDH, FFA and lactate. More importantly, the LTAG treated mice had increased amounts of glycogen and creatine kinase (CK) in their muscles. Glycogen storage is an important source of energy during exercise. It serves a central role in maintaining the body's glucose homeostasis by supplementing blood glucose. Because of this, glycogen is seen as an accurate marker for fatigue, with increased glycogel levels closely associated with improved endurance and anti-fatigue effects. CK, on the other hand, is known to be an accurate indicator of muscle damage. During muscle degeneration, muscle cells are dissolved and their contents enter the bloodstream. As a result, when muscle damage occurs, muscle CK comes out into the blood. As such, fatigue tends to lead to lower muscle CK levels and higher blood CK levels. Higher levels of glycogen and muscle CK in the LTAG treated mice indicated that they experienced less fatigue than the other groups. Based on these findings, the researchers believe that LTAG has potential for use as an anti-fatigue agent.       Mindfulness meditation helps preterm-born adolescents University of Geneva (Switzerland), October 7, 2021 Adolescents born prematurely present a high risk of developing executive, behavioral and socio-emotional difficulties. Now, researchers from Geneva University Hospitals (HUG) and the University of Geneva (UNIGE) have revealed that practicing mindfulness may help improve these various skills. The study, published in the journal Scientific Reports, suggests using mindfulness as a means of clinical intervention with adolescents, whether prematurely born or not. Several studies have already shown that very preterm (VPT) children and adolescents are at higher risk of exhibiting cognitive and socio-emotional problems that may persist into adulthood. To help them overcome the difficulties they face, researchers from the HUG and UNIGE have set up an intervention based on mindfulness, a technique known to have beneficial effects in these areas. Mindfulness consists in training the mind to focus on the present moment, concentrating on physical sensations, on breathing, on the weight of one's body, and even on one's feelings and thoughts, completely judgment-free. The mindfulness-based interventions generally take place in a group with an instructor along with invitations to practice individually at home. To accurately assess the effects of mindfulness, a randomized controlled trial was performed with young adolescents aged 10 to 14, born before 32 weeks gestational weeks. Scientists quickly found that mindfulness improves the regulation of cognitive, social and emotional functions, in other worlds, our brain's ability to interact with our environment. Indeed, it increases the ability to focus on the present—on thoughts, emotions and physical sensations, with curiosity and non-judgment. Thanks to this practice, adolescents improve their executive functions, i.e. the mental processes that enable us to control our behavior to successfully achieve a goal. As a result, young people find it easier to focus, manage and regulate their behavior and emotions in everyday life. For eight weeks, the young teens spent an hour and a half each week with two mindfulness instructors. They were further encouraged to practice mindfulness daily at home. Parents were also involved in this study. They were asked to observe their child's executive functions, for example the ability to regulate their emotions and attentional control, their relationships with others and their behavior. The adolescents also underwent a series of computerized tasks to assess their reactions to events. A comparison of their test results with a control group that did not practice mindfulness shows a positive impact of the intervention on the adolescents' everyday life and on their ability to react to new events. "Each teenager is unique, with their own strenghts and difficulties. Through their involvement in this study, our volunteers have contributed to show that mindfulness can help many young people to feel better, to refocus and to face the world, whether they were born preterm born or not," agree Dr. Russia Hà-Vinh Leuchter, a consultant in the Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics at Geneva University Hospitals, and Dr. Vanessa Siffredi, a researcher at the Child Development Laboratory at the Department of Paediatrics, Gynaecology and Obstetrics at the UNIGE Faculty of Medicine, two of the authors of this work. "However, while the practice of meditation can be a useful resource, it is important to be accompanied by well-trained instructors", they specify. The adolescents who took part in the program are now between 14 and 18 years. Scientists are currently evaluating the long-term effects of mindfulness-based intervention on their daily attention and stress. Furthermore, to validate their clinical data with neurobiological measurements, researchers are currently studying the effects of mindfulness on the brain using magnetic resonance imaging (MRI).   Iron deficiency in middle age is linked with higher risk of developing heart disease University Heart and Vasculature Centre Hamburg (Germany) 6 October 2021 Approximately 10% of new coronary heart disease cases occurring within a decade of middle age could be avoided by preventing iron deficiency, suggests a study published today in ESC Heart Failure, a journal of the European Society of Cardiology (ESC).1 “This was an observational study and we cannot conclude that iron deficiency causes heart disease,” said study author Dr. Benedikt Schrage of the University Heart and Vasculature Centre Hamburg, Germany. “However, evidence is growing that there is a link and these findings provide the basis for further research to confirm the results.” Previous studies have shown that in patients with cardiovascular diseases such as heart failure, iron deficiency was linked to worse outcomes including hospitalisations and death. Treatment with intravenous iron improved symptoms, functional capacity, and quality of life in patients with heart failure and iron deficiency enrolled in the FAIR-HF trial.2 Based on these results, the FAIR-HF 2 trial is investigating the impact of intravenous iron supplementation on the risk of death in patients with heart failure. The current study aimed to examine whether the association between iron deficiency and outcomes was also observed in the general population. The study included 12,164 individuals from three European population-based cohorts. The median age was 59 years and 55% were women. During the baseline study visit, cardiovascular risk factors and comorbidities such as smoking, obesity, diabetes and cholesterol were assessed via a thorough clinical assessment including blood samples. Participants were classified as iron deficient or not according to two definitions: 1) absolute iron deficiency, which only includes stored iron (ferritin); and 2) functional iron deficiency, which includes iron in storage (ferritin) and iron in circulation for use by the body (transferrin). Dr. Schrage explained: “Absolute iron deficiency is the traditional way of assessing iron status but it misses circulating iron. The functional definition is more accurate as it includes both measures and picks up those with sufficient stores but not enough in circulation for the body to work properly.” Participants were followed up for incident coronary heart disease and stroke, death due to cardiovascular disease, and all-cause death. The researchers analysed the association between iron deficiency and incident coronary heart disease, stroke, cardiovascular mortality, and all-cause mortality after adjustments for age, sex, smoking, cholesterol, blood pressure, diabetes, body mass index, and inflammation. Participants with a history of coronary heart disease or stroke at baseline were excluded from the incident disease analyses. At baseline, 60% of participants had absolute iron deficiency and 64% had functional iron deficiency. During a median follow-up of 13.3 years there were 2,212 (18.2%) deaths. Of these, a total of 573 individuals (4.7%) died from a cardiovascular cause. Incidence coronary heart disease and stroke were diagnosed in 1,033 (8.5%) and 766 (6.3%) participants, respectively. Functional iron deficiency was associated with a 24% higher risk of coronary heart disease, 26% raised risk of cardiovascular mortality, and 12% increased risk of all-cause mortality compared with no functional iron deficiency. Absolute iron deficiency was associated with a 20% raised risk of coronary heart disease compared with no absolute iron deficiency, but was not linked with mortality. There were no associations between iron status and incident stroke. The researchers calculated the population attributable fraction, which estimates the proportion of events in 10 years that would have been avoided if all individuals had the risk of those without iron deficiency at baseline. The models were adjusted for age, sex, smoking, cholesterol, blood pressure, diabetes, body mass index, and inflammation. Within a 10-year period, 5.4% of all deaths, 11.7% of cardiovascular deaths, and 10.7% of new coronary heart disease diagnoses were attributable to functional iron deficiency. “This analysis suggests that if iron deficiency had been absent at baseline, about 5% of deaths, 12% of cardiovascular deaths, and 11% of new coronary heart disease diagnoses would not have occurred in the following decade,” said Dr. Schrage. “The study showed that iron deficiency was highly prevalent in this middle-aged population, with nearly two-thirds having functional iron deficiency,” said Dr. Schrage. “These individuals were more likely to develop heart disease and were also more likely to die during the next 13 years.” Dr. Schrage noted that future studies should examine these associations in younger and non-European cohorts. He said: “If the relationships are confirmed, the next step would be a randomised trial investigating the effect of treating iron deficiency in the general population.”     Consumption of a bioactive compound from Neem plant could significantly suppress development of prostate cancer National University of Singapore, September 29, 2021   Oral administration of nimbolide, over 12 weeks shows reduction of prostate tumor size by up to 70 per cent and decrease in tumor metastasis by up to 50 per cent   A team of international researchers led by Associate Professor Gautam Sethi from the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore (NUS) has found that nimbolide, a bioactive terpenoid compound derived from Azadirachta indica or more commonly known as the neem plant, could reduce the size of prostate tumor by up to 70 per cent and suppress its spread or metastasis by half.   Prostate cancer is one of the most commonly diagnosed cancers worldwide. However, currently available therapies for metastatic prostate cancer are only marginally effective. Hence, there is a need for more novel treatment alternatives and options.   "Although the diverse anti-cancer effects of nimbolide have been reported in different cancer types, its potential effects on prostate cancer initiation and progression have not been demonstrated in scientific studies. In this research, we have demonstrated that nimbolide can inhibit tumor cell viability -- a cellular process that directly affects the ability of a cell to proliferate, grow, divide, or repair damaged cell components -- and induce programmed cell death in prostate cancer cells," said Assoc Prof Sethi.   Nimbolide: promising effects on prostate cancer   Cell invasion and migration are key steps during tumor metastasis. The NUS-led study revealed that nimbolide can significantly suppress cell invasion and migration of prostate cancer cells, suggesting its ability to reduce tumor metastasis. The researchers observed that upon the 12 weeks of administering nimbolide, the size of prostate cancer tumor was reduced by as much as 70 per cent and its metastasis decreased by about 50 per cent, without exhibiting any significant adverse effects.   "This is possible because a direct target of nimbolide in prostate cancer is glutathione reductase, an enzyme which is responsible for maintaining the antioxidant system that regulates the STAT3 gene in the body. The activation of the STAT3 gene has been reported to contribute to prostate tumor growth and metastasis," explained Assoc Prof Sethi. "We have found that nimbolide can substantially inhibit STAT3 activation and thereby abrogating the growth and metastasis of prostate tumor," he added.   The findings of the study were published in the April 2016 issue of the scientific journal Antioxidants & Redox Signaling. This work was carried out in collaboration with Professor Goh Boon Cher of Cancer Science Institute of Singapore at NUS, Professor Hui Kam Man of National Cancer Centre Singapore and Professor Ahn Kwang Seok of Kyung Hee University.   The neem plant belongs to the mahogany tree family that is originally native to India and the Indian sub-continent. It has been part of traditional Asian medicine for centuries and is typically used in Indian Ayurvedic medicine. Today, neem leaves and bark have been incorporated into many personal care products such as soaps, toothpaste, skincare and even dietary supplements.       Review looks at the efficacy of acupuncture in treating insulin resistance Guangzhou University of Chinese Medicine (China), October 8, 2021 In their report, researcherss from Guangzhou University of Chinese Medicine in China explored the role of acupuncture in treating insulin resistance. The study was published in the journal Complementary Therapies in Clinical Practice. Earlier studies have reported the effectiveness of acupuncture in treating insulin resistance and related conditions. The review looked at acupuncture and its effects on clinical outcomes. The researchers searched the following databases for randomized controlled trials involving insulin resistance patients treated with acupuncture: Cochrane Central Register of Controlled Trials Embase Medline (via OVID) China National Knowledge Infrastructure (CNKI) Wan Fang and China Science and Technology Journal Database (VIP) The studies show that homeostasis model assessment of insulin resistance significantly decreased with acupuncture treatment. Other significant decreases include fasting blood glucose, postprandial blood glucose and fasting insulin. Acupuncture increased insulin sensitivity with very few adverse effects. In sum, acupuncture is a safe and effective alternative treatment for insulin resistance.     Blueberries may improve attention in children following double-blind trial University of Reading (UK), October 10, 2021  Primary school children could show better attention by consuming flavonoid-rich blueberries, following a study conducted by the University of Reading. In a paper published in Food & Function, a group of 7-10 year olds who consumed a drink containing wild blueberries or a matched placebo and were tested on their speed and accuracy in completing an executive task function on a computer. The double blind trial found that the children who consumed the flavonoid-rich blueberry drink had 9% quicker reaction times on the test without any sacrifice of accuracy. In particular, the effect was more noticeable as the tests got harder. Professor Claire Williams, a neuroscience professor at the University of Reading said: "This is the first time that we have seen the positive impact that flavonoids can have on the executive function of children. We designed this double blind trial especially to test how flavonoids would impact on attention in young people as it's an area of cognitive performance that hasn't been measured before. "We used wild blueberries as they are rich in flavonoids, which are compounds found naturally in foods such as fruits and their juices, vegetables and tea. They have been associated with a range of health benefits including antioxidant and anti-inflammatory effects, and our latest findings continue to show that there is a beneficial cognitive effect of consuming fruit and vegetables, tea, coffee and even dark chocolate which all contain flavonoids." The children were then asked to pay attention to an array of arrows shown on a PC screen and press a key corresponding to the direction that the central arrow was facing. The task was repeated over a number of trials, where cognitive demand was manipulated by varying how quickly the arrows appeared, whether there were additional arrows appearing either side of the central arrow, and whether the flanking arrows were pointing in the same/different direction as the central arrow. Previous Reading research has shown that consuming wild blueberries can improve mood in children and young people, simple memory recall in primary school children, and that other flavonoid rich drinks such as orange juice, can also improve memory and concentration. The Wild Blueberry Association of North America provided a freeze-dried powder made from wild blueberries which was used in the study but did not provide any additional financial support and did not play a role in the design of the study. Wild blueberries are grown and harvested in North America, and are smaller than regular blueberries, and are higher in flavonoids compared to regular varieties. The double-blind trial used a flavonoid-rich wild blueberry drink, with a matched placebo contained 8.9g of fructose, 7.99g of glucose and 4 mg of vitamin C matching the levels of nutrients found in the blueberry drink. The amount of fructose is akin to levels found in a standard pear. This was an executive function task- requiring participants to pay attention to stimuli appearing on screen and responding correctly. The task was a simple one- responding to the direction of an arrow in the middle of a screen (by pressing left/right arrow key) but we then varied how quickly the stimuli appeared, whether there was additional arrows appearing either side of the stimuli and whether those flanking arrows were pointing in the same/different direction as they direction you had to respond. There are 6 main classes of flavonoids: Anthocyanins – found in berry fruits such as the blueberries used in this study and also in red wine. Flavonols - found in onions, leeks, and broccoli Flavones - found in parsley and celery, Isoflavones - found in soy and soy products, Flavanones - found in citrus fruit and tomatoes Flavanols—found in green tea, red wine, and chocolate     Nocebo effect: Does a drug's high price tag cause its own side effects? University Medical Center Hamburg (Germany), October 5, 2021  Pricey drugs may make people more vulnerable to perceiving side effects, a new study suggests—and the phenomenon is not just "in their heads." The study delved into the so-called "nocebo effect." It's the negative version of the well-known placebo effect, where people feel better after receiving a therapy because they expected good things. With the nocebo effect, patients' worries over treatment side effects make them feel sick. In this study, researchers found that people were more likely to report painful side effects from a fake drug when told it was expensive. But it wasn't just something people were "making up." Using brain imaging, the researchers traced the phenomenon to specific activity patterns in the brain and spine. "These findings are a strong argument against the perception of placebo and nocebo effects as being only 'fake' effects—created purely by imagination or delusions of the patient," said lead researcher Alexandra Tinnermann. She is with the University Medical Center Hamburg-Eppendorf, in Germany. Dr. Luana Colloca, a researcher at the University of Maryland in Baltimore, agreed. "This is not merely a reflection of people's biases," said Colloca, who wrote an editorial published with the study. "Expectations do modulate symptoms and patients' responses to treatment," she said. For the study, Tinnermann's team recruited 49 healthy volunteers and randomly assigned them to test one of two itch-relieving "medical creams." In reality, both creams were identical and contained no active ingredients. However, people in both groups were told that the products could have the side effect of making the skin more sensitive to pain. There was only one apparent difference between the two phony creams: One came in fancy packing with a high price tag; the other was cheap. After participants applied the creams to their forearms, the researchers had them undergo a standard test that measured their tolerance for heat-induced pain. It turned out that people who'd used the expensive cream were more sensitive to pain during the tests. On average, their pain rating hovered around a 15—within the "mild" pain range—whereas people using the cheap cream barely registered any discomfort. It's likely, Tinnermann said, that people expect a pricey medication to be potent—which could also make them expect more side effects. Colloca agreed. We are all "vulnerable" to such outside influences, she said, be it a drug's price or how it's given (by IV versus mouth, for instance). However, we are not just imagining those placebo or nocebo effects, both researchers noted. Using functional MRI brain scans, Tinnermann's team found specific patterns of nervous system activity in people who had a nocebo response to the pricey cream. That included a change in "communication" between certain brain structures and the spinal cord, Tinnermann said. According to Colloca, research like this can have practical uses. Doctors could, for instance, inform patients that drug prices or other factors can sway their expectations about a treatment's benefits and risks—and that, in turn, can influence whether they feel better or develop side effects. There is, however, no research into whether that kind of knowledge helps prevent patients from the nocebo effect, Tinnermann said. But, she added, health professionals can be aware that patients' expectations "play a huge role in medicine"—and be mindful of how they talk about a medication and its possible side effects. It's an important matter, Colloca said, because the nocebo effect can cause people to stop taking needed medications. Colloca pointed to the example of cholesterol-lowering statins. The potential for those medications to cause muscle pain has been widely reported. And one recent study found evidence that this knowledge can make statin users more likely to report muscle pain side effects. Other research, Colloca said, has shown that when people stop taking their statins, their risk of heart attack and stroke rises.

Genuine Chit-Chat
#140 – It's Okay To Laugh If You Like It: Bizarre Dreams, A Boringtopia & Writing In First Person With Jesse McKinnell

Genuine Chit-Chat

Play Episode Listen Later Oct 10, 2021 56:27


Dead cats, anarchy and cynicism are topics merely scratching the surface of what Jesse McKinnell's works of fiction delve into – Mike had an amazing time speaking with the author from Maine and this conversation is sure to pique your interest of his 2 current books and the ones to come! In more detail, Mike & Jesse discuss the strange dream Jesse had that started his journey on writing his first book; Dead Cats And Other Reflections On Parenthood, why he wrote in first person, the idea of a “boringtopia”, how Jesse writes dark comedy and how an audience roots for a main character even when “bad”. They also discuss suffocation by technology, waiting rooms and the next books Jesse will be releasing! Jesse's Site: https://jessemckinnell.com/ - Read The First Chapter Of Dead Cats For Free Here - Jesse's Instagram: @JesseMcKinnell Last episode, number 140, Mike sat down with Ria Carrogan: the passionate podcasting extraordinaire and their 2-part conversation bounces between a huge range of topics including coping with depression, random questions (including favourite types of ice), mindset and so much more – a conversation covering couple of darker topics, intertwined with humour & somewhat cheery optimism, definitely one to check out! Promo By American Slacker: https://www.aspodcast.com/   Intro & Outro reads by BZ The Voice: http://www.bzthevoice.com/ eck out Mike's Patreon, where he releases 1 or 2 episodes of his “Afterthoughts” a week, plus there are unsplit full-length episodes of GCC, additional photos (including early access to photos of comics for this very show) and more, so if you want to support the show and get more content, check it out at http://patreon.com/genuinechitchat Find Mike's other show; Star Wars: Comics In Canon on Spotify & the other podcast apps on the feed of Comics In Motion. Episodes are out every Saturday; episodes 0-73 are out now, in ep 73 Mike embarks on the first volume of the 2020 run of Star Wars, in ep 72 Mike tackles the third full chapter of the War Of The Bounty Hunters crossover event and in ep 71 Mike dives into the second volume of 2020 Aphra comics (that leads into War Of The Bounty Hunters)! Previous episodes topics include Lando comics, the Journals of Old Ben Kenobi, Kanan Jarrus, Count Dooku, Kylo Ren, Darth Maul, how C-3PO got his red arm, book reviews & more – https://spoti.fi/3sOtqCw Mike appeared on Star Wars Timeline's Timecast, talking about the different SW trilogies, found here: https://youtu.be/W03gonK4rtw Mike along with 5 other members of Comics In Motion discussed Art Spiegelman's Maus in the 2nd CiM Book Club: https://bit.ly/BC2Maus Mike appeared on the Have Not Seen This podcast, talking about The Way Way Back: https://spoti.fi/3AbPcV4 Instagram – Twitter – Facebook – YouTube – Stitcher – Podbean – Spotify You can also email Mike at GenuineChitChat@outlook.com with any reviews, comments or suggestions.

StarDate Podcast
Moon and Venus

StarDate Podcast

Play Episode Listen Later Oct 9, 2021 2:14


Venus has been largely ignored over the last decade or two. Only one spacecraft is operating at the planet now — a Japanese orbiter. Several craft have taken a peek as they've flown past Venus while they were using its gravity to sling them elsewhere in the solar system. But most of the planetary attention has been focused on Mars. That neglect is scheduled to end soon, because the United States and Europe have approved new missions to the planet. The U.S. will send two missions — the first since the 1990s. DAVINCI+ will drop instruments into Venus's hot, dense atmosphere. They'll examine the atmosphere and snap pictures of the surface below. The mission also includes an orbiter, which will image the planet at wavelengths that are invisible to the eye. VERITAS is also an orbiter. It will map the surface by using radar to peer through the clouds that blanket Venus. It'll also look for active volcanoes. Previous missions have found hints that some volcanoes are active, but no confirmation. The European mission is called EnVision. It, too, will map the surface and look for volcanoes. It'll also probe the layers below the surface — helping scientists figure out just how active our neighbor world really is. Look for Venus low in the southwest after sunset. It's the brilliant “evening star,” so you can't miss it. Tonight, it's close below the crescent Moon, with the bright star Antares off to their left.  Script by Damond Benningfield Support McDonald Observatory

Real Estate News: Real Estate Investing Podcast
New Challenges, New Opportunities for Real Estate Investors

Real Estate News: Real Estate Investing Podcast

Play Episode Listen Later Oct 9, 2021 5:55


Real estate investors have experienced some big swings in the market over the past decade. We've gone from dirt cheap foreclosures after the housing meltdown, to more difficult investing opportunities today. According to a new survey, that's discouraging many small scale real estate investors, but difficult doesn't mean impossible. It means you need to be flexible, adaptable, and smart about your choices.Hi, I'm Kathy Fettke and this is Real Estate News for Investors. If you like our podcast, please subscribe and leave us a review.Real-estate data company RealtyTrac conducted an investor sentiment survey among 300 real estate investors from across the country. (1) It shows that 48% of them feel that the investing environment is worse or even “much” worse than it was just one year ago. And it wasn't that much better a year ago. The same survey shows that 45% felt that way in 2020 during the first year of the pandemic.RealtyTrac defines small scale mom-and-pop investors as those who buy one to 10 properties a year. That includes people who flip homes and those why buy and hold them as rentals. RealtyTrack says 90% of the 19 million single-family rental properties in the U.S. are owned by smaller investors. It also says there are thousands of people flipping homes at a rate of about one a month, although they are facing more competition from iBuyers like Opendoor, Offerpad, and Zillow. Investor Sentiment SurveyThis is the second year in a row for the RealtyTrac Investor Sentiment Survey. RealtyTrac says that last year's survey was evenly split between flippers and buy-and-hold investors. This year, there were more buy-and-hold rental property investors. Researchers say that could be the result of market conditions which are reducing home-flipping returns.Previous research by RealtyTrac's parent company ATTOM Data Solutions shows that the typical gross-flipping profit was $67,000 in the second quarter of this year. That's a 33.5% return on investment compared to a 40.6% ROI for Q2 in 2020. It's also the lowest ROI for flippers since 2011. (2)RealtyTrac's survey found that real estate investors are most concerned about high home prices. That concern replaced lack of inventory as the biggest worry in last year's survey. Lack of inventory is now second on the list of concerns. Investors are also worried about the cost of materials and labor along with competition from regular homebuyers.RealtyTrac's Rick Sharga says: “Investors are more optimistic about the future than they are about current market conditions. But they do worry about inflation -- about 81% of the investors surveyed were concerned about inflation causing material and labor costs to rise, making affordability an issue for prospective homebuyers and renters, and increasing the costs of financing.”The survey also asked investors about their foreclosure expectations once government protections expire. About 30% of them expect foreclosures to return to a historical level of about 1% while 33% expect them to increase, but remain below the levels we saw during the Great Recession. Real Estate Investors Need to Shift FocusThe survey title suggests that “Real Estate Investors Have Soured on the Current Market.” I think a better title might be: “Real Estate Investors Need to Shift their Focus.” At least that's what we are doing at RealWealth.The market is changing, again. It's something that the market will always do, so investors need to be flexible and adapt to new conditions. The last ten or so years have been easy for real estate investors. We had a housing crash and dirt cheap prices. But those prices have been rising for a decade. So what now?Yes, it's harder to get inventory. One of our property providers says that foreclosure auctions have completely stopped so she's trying to build new homes for buy-and-hold rental investors, although that has its own challenges.We are in a new market cycle, so investors need to be more creative. In California, new laws have neutralized the idea of single-family zoning. You can now subdivide a single-family property into a duplex, or even a four-plex if the lot is big enough. Investors could live in one, and rent the rest. Short-term rentals could also work, if local laws allow them.California also allows in-law units or ADUs on single-family properties which is another way for property owners to create rentals. Creative Investing for Today's MarketMore creative investors might want to look at ways to help aging baby boomers who need assisted living, or younger professional who need a place to decompress. One of my friends is now turning high-end homes into rehab centers for individuals who need a get-away place to recuperate. Empty hotels could provide an interesting opportunity for apartment conversions. What should you look for? As you know, homes are selling quickly, but that's not 100%. You can look for higher-priced homes that have been sitting on the market for too long and negotiate the price tag. At RealWealth, our teams are helping builders buy land for the development of single-family rentals. By contributing to these projects at the beginning, we are also able to help builders understand the difference between a rental home and a primary residence in terms of design and materials. You can also learn more about single-family rentals by joining RealWealth for free. As a member, you have access to the Investor Portal where you can view sample property pro-formas and connect with our network of resources. That includes experienced investment counselors, property teams, lenders, 1031 exchange facilitators, attorneys, CPAs and more.You'll also find links to information about RealtyTrac's survey in the show notes. And please remember to hit the subscribe button, and leave a review!Thanks for listening. I'm Kathy Fettke.Links:1 - https://www.businesswire.com/news/home/20210929005109/en/Real-Estate-Investors-Have-Soured-on-the-Current-Market-According-to-the-Fall-2021-RealtyTrac%C2%AE-Investor-Sentiment-Survey%E2%84%A22 - https://www.attomdata.com/news/market-trends/flipping/attom-q2-2021-u-s-home-flipping-report/

The Gary Null Show
The Gary Null Show - 10.08.21

The Gary Null Show

Play Episode Listen Later Oct 8, 2021 59:38


Raspberries, ellagic acid reveal benefits in two studies Oregon State University, October 1, 2021.    Articles that appeared recently in the Journal of Berry Research report that raspberries and compounds present in the fruit could help support healthy body mass and motor function, including balance, coordination and strength.   In one study, Neil Shay and colleagues at Oregon State University fed mice a high fat, high sugar diet plus one of the following: raspberry juice concentrate, raspberry puree concentrate, raspberry fruit powder, raspberry seed extract, ellagic acid (a polyphenol that occurs in a relatively high amount in raspberries), raspberry ketone, or a combination of raspberry ketone and ellagic acid. Additional groups of animals received a high fat, high sugar diet alone or a low fat diet.   While mice that received the high fat and sugar diet alone experienced a significant increase in body mass, the addition of raspberry juice concentrate, raspberry puree concentrate or ellagic acid plus raspberry ketone helped prevent this effect. Of note, mice that received raspberry juice concentrate experienced gains similar to those of animals given a low fat diet. "We hope that the findings from this study can help guide the design of future clinical trials," Dr Shay stated.   In another study, Barbara Shukitt-Hale, PhD, and her associates at Tufts University's Human Nutrition Research Center on Aging gave 19 month old rats a control diet or a diet enhanced with raspberry extract for 11 weeks. Psychomotor behavior was assessed during week 7 and cognitive testing was conducted during weeks 9-10.   Animals that received raspberry performed better on psychomotor coordination and balance, and had better muscle tone, strength and stamina than those that received a control diet. "These results may have important implications for healthy aging," stated Dr Shukitt-Hale. "While further research in humans is necessary, animal model studies are helpful in identifying deficits associated with normal aging."       Massage doesn't just make muscles feel better, it makes them heal faster and stronger Harvard University, October 6, 2021 Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes." Using a custom-designed robotic system to deliver consistent and tunable compressive forces to mice's leg muscles, the team found that this mechanical loading (ML) rapidly clears immune cells called neutrophils out of severely injured muscle tissue. This process also removed inflammatory cytokinesreleased by neutrophils from the muscles, enhancing the process of muscle fiber regeneration. The research is published in Science Translational Medicine. "Lots of people have been trying to study the beneficial effects of massage and other mechanotherapies on the body, but up to this point it hadn't been done in a systematic, reproducible way. Our work shows a very clear connection between mechanical stimulation and immune function. This has promise for regenerating a wide variety of tissues including bone, tendon, hair, and skin, and can also be used in patients with diseases that prevent the use of drug-based interventions," said first author Bo Ri Seo, Ph.D., who is a Postdoctoral Fellow in the lab of Core Faculty member Dave Mooney, Ph.D. at the Wyss Institute and SEAS. Seo and her coauthors started exploring the effects of mechanotherapy on injured tissues in mice several years ago, and found that it doubled the rate of muscle regeneration and reduced tissue scarring over the course of two weeks. Excited by the idea that mechanical stimulation alone can foster regeneration and enhance muscle function, the team decided to probe more deeply into exactly how that process worked in the body, and to figure out what parameters would maximize healing. They teamed up with soft robotics experts in the Harvard Biodesign Lab, led by Wyss Associate Faculty member Conor Walsh, Ph.D., to create a small device that used sensors and actuators to monitor and control the force applied to the limb of a mouse. " The device we created allows us to precisely control parameters like the amount and frequency of force applied, enabling a much more systematic approach to understanding tissue healing than would be possible with a manual approach," said co-second author Christopher Payne, Ph.D., a former Postdoctoral Fellow at the Wyss Institute and the Harvard Biodesign Lab who is now a Robotics Engineer at Viam, Inc.  Once the device was ready, the team experimented with applying force to mice's leg muscles via a soft silicone tip and used ultrasound to get a look at what happened to the tissue in response. They observed that the muscles experienced a strain of between 10-40%, confirming that the tissues were experiencing mechanical force. They also used those ultrasound imaging data to develop and validate a computational model that could predict the amount of tissue strain under different loading forces. They then applied consistent, repeated force to injured muscles for 14 days. While both treated and untreated muscles displayed a reduction in the amount of damaged muscle fibers, the reduction was more pronounced and the cross-sectional area of the fibers was larger in the treated muscle, indicating that treatment had led to greater repair and strength recovery. The greater the force applied during treatment, the stronger the injured muscles became, confirming that mechanotherapy improves muscle recovery after injury. But how? Evicting neutrophils to enhance regeneration To answer that question, the scientists performed a detailed biological assessment, analyzing a wide range of inflammation-related factors called cytokines and chemokines in untreated vs. treated muscles. A subset of cytokines was dramatically lower in treated muscles after three days of mechanotherapy, and these cytokines are associated with the movement of immune cells called neutrophils, which play many roles in the inflammation process. Treated muscles also had fewer neutrophils in their tissue than untreated muscles, suggesting that the reduction in cytokines that attract them had caused the decrease in neutrophil infiltration. The team had a hunch that the force applied to the muscle by the mechanotherapy effectively squeezed the neutrophils and cytokines out of the injured tissue. They confirmed this theory by injecting fluorescent molecules into the muscles and observing that the movement of the molecules was more significant with force application, supporting the idea that it helped to flush out the muscle tissue. To pick apart what effect the neutrophils and their associated cytokines have on regenerating muscle fibers, the scientists performed in vitro studies in which they grew muscle progenitor cells (MPCs) in a medium in which neutrophils had previously been grown. They found that the number of MPCs increased, but the rate at which they differentiated (developed into other cell types) decreased, suggesting that neutrophil-secreted factors stimulate the growth of muscle cells, but the prolonged presence of those factors impairs the production of new muscle fibers. "Neutrophils are known to kill and clear out pathogens and damaged tissue, but in this study we identified their direct impacts on muscle progenitor cell behaviors," said co-second author Stephanie McNamara, a former Post-Graduate Fellow at the Wyss Institute who is now an M.D.-Ph.D. student at Harvard Medical School (HMS). "While the inflammatory response is important for regeneration in the initial stages of healing, it is equally important that inflammation is quickly resolved to enable the regenerative processes to run its full course." Seo and her colleagues then turned back to their in vivo model and analyzed the types of muscle fibers in the treated vs. untreated mice 14 days after injury. They found that type IIX fibers were prevalent in healthy muscle and treated muscle, but untreated injured muscle contained smaller numbers of type IIX fibers and increased numbers of type IIA fibers. This difference explained the enlarged fiber size and greater force production of treated muscles, as IIX fibers produce more force than IIA fibers. Finally, the team homed in on the optimal amount of time for neutrophil presence in injured muscle by depleting neutrophils in the mice on the third day after injury. The treated mice's muscles showed larger fiber size and greater strength recovery than those in untreated mice, confirming that while neutrophils are necessary in the earliest stages of injury recovery, getting them out of the injury site early leads to improved muscle regeneration. "These findings are remarkable because they indicate that we can influence the function of the body's immune system in a drug-free, non-invasive way," said Walsh, who is also the Paul A. Maeder Professor of Engineering and Applied Science at SEAS and whose group is experienced in developing wearable technology for diagnosing and treating disease. "This provides great motivation for the development of external, mechanical interventions to help accelerate and improve muscle and tissue healing that have the potential to be rapidly translated to the clinic." The team is continuing to investigate this line of research with multiple projects in the lab. They plan to validate this mechanotherpeutic approach in larger animals, with the goal of being able to test its efficacy on humans. They also hope to test it on different types of injuries, age-related muscle loss, and muscle performance enhancement. "The fields of mechanotherapy and immunotherapy rarely interact with each other, but this work is a testament to how crucial it is to consider both physical and biological elements when studying and working to improve human health," said Mooney, who is the corresponding author of the paper and the Robert P. Pinkas Family Professor of Bioengineering at SEAS. "The idea that mechanics influence cell and tissue function was ridiculed until the last few decades, and while scientists have made great strides in establishing acceptance of this fact, we still know very little about how that process actually works at the organ level. This research has revealed a previously unknown type of interplay between mechanobiology and immunology that is critical for muscle tissue healing, in addition to describing a new form of mechanotherapy that potentially could be as potent as chemical or gene therapies, but much simpler and less invasive," said Wyss Founding Director Don Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at (HMS) and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS.   Vitamin E could help protect older men from pneumonia University of Helsinki (Finland), October 7 2021.    An article that appeared in Clinical Interventions in Aging reported a protective role for vitamin E against pneumonia in older men.   For the current investigation, Dr Harri Hemilä of the University of Helsinki, Finland analyzed data from the Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study conducted in Finland. The trial included 29,133 men between the ages of 50 to 69 years who smoked at least five cigarettes daily upon enrollment. Participants received alpha tocopherol (vitamin E), beta carotene, both supplements, or a placebo for five to eight years.   The current study was limited to 7,469 ATBC participants who started smoking at age 21 or older. Among this group, supplementation with vitamin E was associated with a 35% lower risk of developing pneumonia in comparison with those who did not receive the vitamin.  Light smokers who engaged in leisure time exercise had a 69% lower risk compared with unsupplemented members of this subgroup. The risk in this subgroup of developing pneumonia by age 74 was 12.9%.   Among the one-third of the current study's population who quit smoking for a median period of two years, there was a 72% lower risk of pneumonia in association with vitamin E supplementation. In this group, exercisers who received vitamin E experienced an 81% lower pneumonia risk.   Dr Hemilä observed that the benefit for vitamin E in this study was strongest for older subjects—a group at higher risk of pneumonia.   "The current analysis of individual-level data suggests that trials on vitamin E and pneumonia on nonsmoking elderly males are warranted," he concluded.       Toxic fatty acids to blame for brain cell death after injury New York University, October 7, 2021 Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases that affect brain function, as well as the natural breakdown of brain cells seen in aging, researchers say. Previous research has pointed to astrocytes—a star-shaped glial cell of the central nervous system—as the culprits behind cell death seen in Parkinson's disease and dementia, among other neurodegenerative diseases. While many experts believed that these cells released a neuron-killing molecule to "clear away" damaged brain cells, the identity of this toxin has until now remained a mystery. Led by researchers at NYU Grossman School of Medicine, the new investigation provides what they say is the first evidence that tissue damage prompts astrocytes to produce two kinds of fats, long-chain saturated free fatty acids and phosphatidylcholines. These fats then trigger cell death in damaged neurons, the electrically active cells that send messages throughout nerve tissue. Publishing Oct. 6 in the journal Nature, the study also showed that when researchers blocked fatty acid formation in mice, 75 percent of neurons survived compared with 10 percent when the fatty acids were allowed to form. The researchers' earlier work showed that brain cells continued to function when shielded from astrocyte attacks.  "Our findings show that the toxic fatty acids produced by astrocytes play a critical role in brain cell death and provide a promising new target for treating, and perhaps even preventing, many neurodegenerative diseases," says study co-senior author Shane Liddelow, Ph.D. Liddelow, an assistant professor in the Department of Neuroscience and Physiology at NYU Langone Health, adds that targeting these fats instead of the cells that produce them may be a safer approach to treating neurodegenerative diseasesbecause astrocytes feed nerve cells and clear away their waste. Stopping them from working altogether could interfere with healthy brain function. Although it remains unclear why astrocytes produce these toxins, it is possible they evolved to destroy damaged cells before they can harm their neighbors, says Liddelow. He notes that while healthy cells are not harmed by the toxins, neurons become susceptible to the damaging effects when they are injured, mutated, or infected by prions, the contagious, misfolded proteins that play a major role in mad cow disease and similar illnesses. Perhaps in chronic diseases like dementia, this otherwise helpful process goes off track and becomes a problem, the study authors say. For the investigation, researchers analyzed the molecules released by astrocytes collected from rodents. They also genetically engineered some groups of mice to prevent the normal production of the toxic fats and looked to see whether neuron death occurred after an acute injury. "Our results provide what is likely the most detailed molecular map to date of how tissue damage leads to brain cell death, enabling researchers to better understand why neurons die in all kinds of diseases," says Liddelow, also an assistant professor in the Department of Ophthalmology at NYU Langone. Liddelow cautions that while the findings are promising, the genetic techniques used to block the enzyme that produces toxic fatty acids in mice are not ready for use in humans. As a result, the researchers next plan is to explore safe and effective ways to interfere with the release of the toxins in human patients. Liddelow and his colleagues had previously shown these neurotoxic astrocytes in the brains of patients with Parkinson's, Huntington's disease, and multiple sclerosis, among other diseases.   Clinical trial for nicotinamide riboside: Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits University of Iowa Health Care, October 3, 2021   In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage.   Studies in mice have shown that boosting the levels of this cell metabolite -- known as NAD+ -- can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline.   These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone clinical trials to see if they work in people.   The new research, reported in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. (NASDAQ: CDXC), which supplied the NR used in the trial. Brenner is a consultant for ChromaDex. He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®.   The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner's lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses.   "This trial shows that oral NR safely boosts human NAD+ metabolism," Brenner says. "We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely."   The next step will be to study the effect of longer duration NR supplementation on NAD+ metabolism in healthy adults, but Brenner also has plans to test the effects of NR in people with diseases and health conditions, including elevated cholesterol, obesity and diabetes, and people at risk for chemotherapeutic peripheral neuropathy.   Prior to the formal clinical trial, Brenner conducted a pilot human study -- on himself. In 2004, he had discovered that NR is a natural product found in milk and that there is pathway to convert NR to NAD+ in people. More than a decade of research on NR metabolic pathways and health effects in mice and rats had convinced him that NR supplementation had real promise to improve human health and wellness. After consulting with UI's institutional review board, he conducted an experiment in which he took 1 gram of NR once a day for seven days, and his team analyzed blood and urine samples using mass spectrometry. The experiment showed that Brenner's blood NAD+ increased by about 2.7 times. In addition, though he reported immediate sensitivity to flushing with the related compound niacin, he did not experience any side effects taking NR.   The biggest surprise from his metabolomic analysis was an increase in a metabolite called NAAD, which was multiplied by 45 times, from trace levels to amounts in the micromolar range that were easily detectable.   "While this was unexpected, I thought it might be useful," Brenner says. "NAD+ is an abundant metabolite and it is sometimes hard to see the needle move on levels of abundant metabolites. But when you can look at a low-abundance metabolite that goes from undetectable to easily detectable, there is a great signal to noise ratio, meaning that NAAD levels could be a useful biomarker for tracking increases in NAD+ in human trials."   Brenner notes this was a case of bidirectional translational science; having learned something from the initial human experiment, his team was able to return to laboratory mice to explore the unexpected NAAD finding in more detail.   Brenner's mouse study showed that NAAD is formed from NR and confirmed that NAAD levels are a strong biomarker for increased NAD+ metabolism. The experiments also revealed more detail about NAD+ metabolic pathways.   In particular, the researchers compared the ability of all three NAD+ precursor vitamins -- NR, niacin, and nicotinamide -- to boost NAD+ metabolism and stimulate the activity of certain enzymes, which have been linked to longevity and healthbenefits. The study showed for the first time that oral NR is superior to nicotinamide, which is better than niacin in terms of the total amount of NAD+ produced at an equivalent dose. NR was also the best of the three in stimulating the activity of sirtuin enzymes. However, in this case, NR was the best at stimulating sirtuin-like activities, followed by niacin, followed by nicotinamide.   The information from the mouse study subsequently helped Brenner's team design the formal clinical trial. In addition to showing that NR boosts NAD+ in humans without adverse effects, the trial confirmed that NAAD is a highly sensitive biomarker of NAD+ supplementation in people.   "Now that we have demonstrated safety in this small clinical trial, we are in a position to find out if the health benefits that we have seen in animals can be reproduced in people," says Brenner, who also is co-director of the Obesity Research and Education Initiative, professor of internal medicine, and a member of the Fraternal Order of Eagles Diabetes Research Center at the UI.   Protecting the ozone layer is delivering vast health benefits Montreal Protocol will spare Americans from 443 million skin cancer cases National Center for Atmospheric Research, October 7, 2021 An international agreement to protect the ozone layer is expected to prevent 443 million cases of skin cancer and 63 million cataract cases for people born in the United States through the end of this century, according to new research. The research team, by scientists at the National Center for Atmospheric Research (NCAR), ICF Consulting, and U.S. Environmental Protection Agency (EPA), focused on the far-reaching impacts of a landmark 1987 treaty known as the Montreal Protocol and later amendments that substantially strengthened it. The agreement phased out the use of chemicals such as chlorofluorocarbons (CFCs) that destroy ozone in the stratosphere. Stratospheric ozone shields the planet from harmful levels of the Sun's ultraviolet (UV) radiation, protecting life on Earth. To measure the long-term effects of the Montreal Protocol, the scientists developed a computer modeling approach that enabled them to look to both the past and the future by simulating the treaty's impact on Americans born between 1890 and 2100. The modeling revealed the treaty's effect on stratospheric ozone, the associated reductions in ultraviolet radiation, and the resulting health benefits.  In addition to the number of skin cancer and cataract cases that were avoided, the study also showed that the treaty, as most recently amended, will prevent approximately 2.3 million skin cancer deaths in the U.S. “It's very encouraging,” said NCAR scientist Julia Lee-Taylor, a co-author of the study. “It shows that, given the will, the nations of the world can come together to solve global environmental problems.” The study, funded by the EPA, was published in ACS Earth and Space Chemistry. NCAR is sponsored by the National Science Foundation. Mounting concerns over the ozone layer Scientists in the 1970s began highlighting the threat to the ozone layer when they found that CFCs, used as refrigerants and in other applications, release chlorine atoms in the stratosphere that set off chemical reactions that destroy ozone. Concerns mounted the following decade with the discovery of an Antarctic ozone hole. The loss of stratospheric ozone would be catastrophic, as high levels of UV radiation have been linked to certain types of skin cancer, cataracts, and immunological disorders. The ozone layer also protects terrestrial and aquatic ecosystems, as well as agriculture. Policy makers responded to the threat with the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer, in which nations agreed to curtail the use of certain ozone-destroying substances. Subsequent amendments strengthened the treaty by expanding the list of ozone-destroying substances (such as halons and hydrochlorofluorocarbons, or HCFCs) and accelerating the timeline for phasing out their use. The amendments were based on Input from the scientific community, including a number of NCAR scientists, that were summarized in quadrennial Ozone Assessment reports. To quantify the impacts of the treaty, the research team built a model known as the Atmospheric and Health Effects Framework. This model, which draws on various data sources about ozone, public health, and population demographics, consists of five computational steps. These simulate past and future emissions of ozone-destroying substances, the impacts of those substances on stratospheric ozone, the resulting changes in ground-level UV radiation, the U.S. population's exposure to UV radiation, and the incidence and mortality of health effects resulting from the exposure. The results showed UV radiation levels returning to 1980 levels by the mid-2040s under the amended treaty. In contrast, UV levels would have continued to increase throughout this century if the treaty had not been amended, and they would have soared far higher without any treaty at all.  Even with the amendments, the simulations show excess cases of cataracts and various types of skin cancer beginning to occur with the onset of ozone depletion and peaking decades later as the population exposed to the highest UV levels ages. Those born between 1900 and 2040 experience heightened cases of skin cancer and cataracts, with the worst health outcomes affecting those born between about 1950 and 2000. However, the health impacts would have been far more severe without the treaty, with cases of skin cancer and cataracts rising at an increasingly rapid rate through the century.  “We peeled away from disaster,” Lee-Taylor said. “What is eye popping is what would have happened by the end of this century if not for the Montreal Protocol. By 2080, the amount of UV has tripled. After that, our calculations for the health impacts start to break down because we're getting so far into conditions that have never been seen before.” The research team also found that more than half the treaty's health benefits could be traced to the later amendments rather than the original 1987 Montreal Protocol. Overall, the treaty prevented more than 99% of potential health impacts that would have otherwise occurred from ozone destruction. This showed the importance of the treaty's flexibility in adjusting to evolving scientific knowledge, the authors said. The researchers focused on the U.S. because of ready access to health data and population projections. Lee-Taylor said that the specific health outcomes in other countries may vary, but the overall trends would be similar. “The treaty had broad global benefits,” she said.     What is Boron? The trace mineral boron provides profound anti-cancer effects, in addition to maintaining stronger bones. Life Extension, September 2021 Boron is a trace mineral found in the earth's crust and in water. Its importance in human health has been underestimated. Boron has been shown to have actions against specific types of malignancies, such as: Cervical cancer: The country Turkey has an extremely low incidence of cervical cancer, and scientists partially attribute this to its boron-rich soil.1 When comparing women who live in boron-rich regions versus boron-poor regions of Turkey, not a single woman living in the boron-rich regions had any indication of cervical cancer.2(The mean dietary intake of boron for women in this group was 8.41 mg/day.)  Boron interferes with the life cycle of the human papillomavirus (HPV), which is a contributing factor in approximately 95% of all cervical cancers.1  Considering that HPV viruses are increasingly implicated in head and neck cancers,3,4 supplementation with this ultra-low-cost mineral could have significant benefits in protecting against this malignancy that is increasing in prevalence. Lung cancer: A study conducted at the University of Texas MD Anderson Cancer Center between 1995 and 2005 found that increased boron intake was associated with a lower risk of lung cancer in postmenopausal women who were taking hormone replacement therapy. Prostate cancer: Studies point to boron's ability to inhibit the growth and spread of prostate cancer cells.  In one study, when mice were exposed to boric acid, their tumors shrank by as much as 38%.6 One analysis found that increased dietary boron intake was associated with a decreased risk of prostate cancer.7 Several human and animal studies have confirmed the important connection between boron and bone health. Boron prevents calcium loss,8 while also alleviating the bone problems associated with magnesium and vitamin D deficiency.9 All of these nutrients help maintain bone density. A study in female rats revealed the harmful effects a deficiency in boron has on bones, including:10 Decreased bone volume fraction, a measure of bone strength, Decreased thickness of the bone's spongy inner layer, and Decreased maximum force needed to break the femur. And in a study of post-menopausal women, supplementation with3 mg of boron per day prevented calcium loss and bone demineralization by reducing urinary excretion of both calcium and magnesium.8 In addition to its bone and anti-cancer benefits, there are nine additional reasons boron is an important trace mineral vital for health and longevity. It has been shown to:1 Greatly improve wound healing, Beneficially impact the body's use of estrogen, testosterone, and vitamin D, Boost magnesium absorption, Reduce levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α), Raise levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, Protect against pesticide-induced oxidative stress and heavy-metal toxicity, Improve the brain's electrical activity, which may explain its benefits for cognitive performance, and short-term memory in the elderly, Influence the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+), and Potentially help ameliorate the adverse effects of traditional chemotherapeutic agents. Because the amount of boron varies in the soil, based on geographical location, obtaining enough boron through diet alone can be difficult. Supplementing with low-cost boron is an effective way to maintain adequate levels of this overlooked micronutrient.

Nourish Balance Thrive
How to Fix Your Fatigue

Nourish Balance Thrive

Play Episode Listen Later Oct 8, 2021 59:53


Evan Hirsch, MD, is a world-renowned fatigue expert and the Founder & CEO of the International Center for Fatigue. Through his best-selling book, podcast, and online programs, he has helped thousands of people around the world boost their energy naturally, and is on a mission to help a million more. He has been featured widely on television, podcasts, and summits. On this podcast, Evan discusses the many different causes of fatigue and his 4-step process for treating it. He shares details about his Fix Your Fatigue program, which has identified 10 different causes of fatigue - and Evan notes that everyone has multiple causes. To complicate things further, everyone has different multiple causes, so no one treatment works for everyone. Evan shares resources for identifying the causes of your fatigue and simple steps you can take to improve your energy levels today. Here's the outline of this interview with Evan Hirsch: [00:00:20] Gabriel Niles, MD introduced us at the Ancestral Health Symposium. [00:00:41] How Evan became interested in medicine and fatigue. [00:02:28] Book: Fix Your Fatigue: The four step process to resolving chronic fatigue, achieving abundant energy and reclaiming your life!, by Evan H. Hirsch MD. [00:04:29] Viruses that can be transmitted that can end up triggering fatigue. [00:06:21] How to know if you have an abnormal level of fatigue. [00:08:16] Book: This Is Your Mind on Plants, by Michael Pollan. [00:08:41] Surviving on caffeine. [00:09:48] Different levels of fatigue (levels based on treatment needed). [00:11:22] Toxicities that we're exposed to that need to be removed to alleviate fatigue. [00:11:54] 4-Quadrant Model. [00:12:58] Best diets for fixing fatigue. [00:14:14] Mike T. Nelson; Course: Flex Diet Foundations. [00:14:53] 4-step process: 1. assess causes 2. replace deficiencies 3. opening detox pathways 4. remove toxicities. [00:17:19] Adrenals, mitochondria, thyroid - the "Big 3" factors that help restore energy. [00:21:42] "Detox"; Herbal products + external therapies. [00:24:42] Mold exposure and toxicity. [00:28:51] Article: Your building might be making you sick. Joe Allen can help., by Colleen Walsh. [00:30:12] Great Plains Urine MycoTOX Profile to evaluate for mold exposure/toxicity. [00:31:16] Environmental Relative Moldiness Index (ERMI) test - evaluates mold in the environment. Find a professional. [00:31:46] What to do if you have mold exposure: binders, supplements to remove toxins. [00:32:54] Heavy Metals and infections. [00:33:37] COVID long-haulers or post-acute syndromes. [00:35:24] Using symptoms to diagnose conditions. [00:36:01] Bartonella quiz on the www.FixYourFatigue.com website. [00:37:49] Podcast: How to Prevent and Heal Lyme and Its Co-Infections, with Sunjya Schweig, MD. [00:38:13] Herbal antimicrobials vs antibiotics. [00:38:33] Results page of Evan's website. [00:42:30] Book: Cure: A Journey into the Science of Mind Over Body by Jo Marchant. [00:47:18] Electromagnetic Fields; Previous podcasts on EMF: Electromagnetic Fields (EMFs): The Controversy, the Science, and How to Protect Yourself, with Joseph Mercola, DO; EMFs: Why You Should Care and What to Do, with Nick Pineault. [00:51:52] Safe Sleeve cases and other ways to mitigate EMFs. [00:52:41] LessEMF.com. [00:54:05] How to know if your fatigue can be helped. [00:55:38] Find Evan at www.FixYourFatigue.com; Facebook group; Schedule a free discovery call.

Nialler9
Spice Girls, Girl Power and 90s Ladettes with Jenn Gannon

Nialler9

Play Episode Listen Later Oct 8, 2021 60:28


On this week's Nialler9 podcast, Niall and Andrea are joined by Jenn Gannon to talk about a recent piece she wrote for the publication Rogue Collective called Girl powerless: Why the 90s and 00s weren't as empowering as they seemed (available on subscription). Jenn's piece was inspired by watching the recent Channel 4 two-part documentary Spice Girls: How Girl Power Changed Britain, which as well as telling the story of the Spice Girls rise and fall, also discusses '90s Britpop culture at the time from '90s ladettes to Girl Power to how famous women were coerced into playing along to Chris Evans' leering and problematic presenting style on TFI Friday. Jenn joins us to talk about growing up in the era and the early 00s, along with discussions about body-shaming in magazines, lads mags like FHM, the marketing co-opting of the term Girl Power and the retromania of our recent past. TW: there is discussion about weight loss and eating disorders around 42 minutes in. Listen to the episode below or Subscribe in your favourite podcast app: Subscribe in Apple | Android | ACAST | Pocketcasts | CastBox | Stitcher | Spotify | RSS Feed Songs played on the Nialler9 Podcast Spotify Playlist Andrea has a new podcast - My Favourite Album Support Nialler9 on Patreon and join our Discord chat + member playlists and content. Andrea has a Ghost newsletter Subscribe to the podcast and please leave a review on iTunes, tell your friends or commit to supporting us directly. Support us on Patreon. Previous podcast episodes

Wolf In Tune
#29 - The Singer‘s Body - Orville Heyn

Wolf In Tune

Play Episode Listen Later Oct 8, 2021 52:02


Orville Heyn is a professional singer, producer, composer, actor, teacher and mindfulness practitioner. He has worked as a vocal coach in film and television on programs like The Next Star, The List, and The Love Guru. Previous students of his include Mike Myers, Jessica Alba and Telma Hopkins. On this episode, Orville dives into his powerfully unique approach with vocalists: The Singer's Body. He shares the story of creating the program after beginning his relationship with vipassana meditation, and how his practice is based in similar ideologies and perspectives. He and Richard also talk about finding equanimity in the face of fear and change, the importance of improvisation, and interpreting the messages our body's communicate to be your own best teacher. Stay tuned for the end of the episode for a guided demo in Orville's Vocal Resonance exercise.   Follow us on Instagram, Twitter and Facebook @WolfInTune  https://www.richardwolf.net/ Read "In Tune: Music As The Bridge To Mindfulness"  https://tinyurl.com/tz67aqm 

Daily Insights by Rabbi Eli Silberstein
The third incredible story the previous Rebbe tells re the Rhiziner

Daily Insights by Rabbi Eli Silberstein

Play Episode Listen Later Oct 8, 2021 5:53


The third incredible story the previous Rebbe tells re the relationship of the Riziner and the Tzemach Tzedek

The Gary Null Show
The Gary Null Show - 10.07.21

The Gary Null Show

Play Episode Listen Later Oct 7, 2021 51:37


Natural compound in basil may protect against Alzheimer's disease pathology University of South Florida, October 5, 2021 Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer's disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests. The new study published Oct. 5 in the Frontiers in Aging Neuroscience, discovered a sensing mechanism associated with the gut microbiome that explains how fenchol reduces neurotoxicity in the Alzheimer's brain. Emerging evidence indicates that short-chain fatty acids (SCFAs)– metabolites produced by beneficial gut bacteria and the primary source of nutrition for cells in your colon—contribute to brain health. The abundance of SCFAs is often reduced in older patients with mild cognitive impairment and Alzheimer's disease, the most common form of dementia. However, how this decline in SCFAs contributes to Alzheimer's disease progression remains largely unknown. Gut-derived SCFAs that travel through the blood to the brain can bind to and activate free fatty acid receptor 2 (FFAR2), a cell signaling molecule expressed on brain cellscalled neurons. "Our study is the first to discover that stimulation of the FFAR2 sensing mechanism by these microbial metabolites (SCFAs) can be beneficial in protecting brain cells against toxic accumulation of the amyloid-beta (Aβ) protein associated with Alzheimer's disease," said principal investigator Hariom Yadav, Ph.D., professor of neurosurgery and brain repair at the USF Health Morsani College of Medicine, where he directs the USF Center for Microbiome Research. One of the two hallmark pathologies of Alzheimer's disease is hardened deposits of Aβ that clump together between nerve cells to form amyloid protein plaques in the brain. The other is neurofibrillary tangles of tau protein inside brain cells. These pathologies contribute to the neuron loss and death that ultimately cause the onset of Alzheimer's, a neurodegenerative disease characterized by loss of memory, thinking skills and other cognitive abilities. Dr. Yadav and his collaborators delve into molecular mechanisms to explain how interactions between the gut microbiome and the brain might influence brain health and age-related cognitive decline. In this study, Dr. Yadav said, the research team set out to uncover the "previously unknown" function of FFAR2 in the brain. The researchers first showed that inhibiting the FFAR2 receptor (thus blocking its ability to "sense" SCFAs in the environment outside the neuronal cell and transmit signaling inside the cell) contributes to the abnormal buildup of the Aβ protein causing neurotoxicity linked to Alzheimer's disease. Then, they performed large-scale virtual screening of more than 144,000 natural compounds to find potential candidates that could mimic the same beneficial effect of microbiota produced SCFAs in activating FFAR2 signaling. Identifying a natural compound alternative to SCFAs to optimally target the FFAR2 receptor on neurons is important, because cells in the gut and other organs consume most of these microbial metabolites before they reach the brain through blood circulation, Dr. Yadav noted. Dr. Yadav's team narrowed 15 leading compound candidates to the most potent one. Fenchol, a plant-derived compound that gives basil its aromatic scent, was best at binding to the FFAR's active site to stimulate its signaling. Further experiments in human neuronal cell cultures, as well as Caenorhabditis (C.) elegans (worm) and mouse models of Alzheimer's disease demonstrated that fenchol significantly reduced excess Aβ accumulation and death of neurons by stimulating FFAR2 signaling, the microbiome sensing mechanism. When the researchers more closely examined how fenchol modulates Aβ-induced neurotoxicity, they found that the compound decreased senescent neuronal cells, also known as "zombie" cells, commonly found in brains with Alzheimer's disease pathology. Zombie cells stop replicating and die a slow death. Meanwhile, Dr. Yadav said, they build up in diseased and aging organs, create a damaging inflammatory environment, and send stress or death signals to neighboring healthy cells, which eventually also change into harmful zombie cells or die. "Fenchol actually affects the two related mechanisms of senescence and proteolysis," Dr. Yadav said of the intriguing preclinical study finding. "It reduces the formation of half-dead zombie neuronal cells and also increases the degradation of (nonfunctioning) Aβ, so that amyloid protein is cleared from the brain much faster." Before you start throwing lots of extra basil in your spaghetti sauce or anything else you eat to help stave off dementia, more research is needed—including in humans. In exploring fenchol as a possible approach for treating or preventing Alzheimer's pathology, the USF Health team will seek answers to several questions. A key one is whether fenchol consumed in basil itself would be more or less bioactive (effective) than isolating and administering the compound in a pill, Dr. Yadav said. "We also want to know whether a potent dose of either basil or fenchol would be a quicker way to get the compound into the brain."   Researchers find sense of purpose associated with better memory Florida State University, October 6, 2021 Add an improved memory to the list of the many benefits that accompany having a sense of purpose in life. A new study led by Florida State University researchers showed a link between an individual's sense of purpose and their ability to recall vivid details. The researchers found that while both a sense of purpose and cognitive function made memories easier to recall, only a sense of purpose bestowed the benefits of vividness and coherence. The study, which focused on memories related to the COVID-19 pandemic, was published in the journal Memory. "Personal memories serve really important functions in everyday life," said Angelina Sutin, a professor in the College of Medicine and the paper's lead author. "They help us to set goals, control emotions and build intimacy with others. We also know people with a greater sense of purpose perform better on objective memory tests, like remembering a list of words. We were interested in whether purpose was also associated with the quality of memories of important personal experiences because such qualities may be one reason why purpose is associated with better mental and physical health." Nearly 800 study participants reported on their sense of purpose and completed tasks that measured their cognitive processing speed in January and February 2020, before the ongoing coronavirus pandemic took hold in the U.S. Researchers then measured participants' ability to retrieve and describe personal memories about the pandemic in July 2020, several months into the public health crisis. Participants with a stronger sense of purpose in life reported that their memories were more accessible, coherent and vivid than participants with less purpose. Those with a higher sense of purpose also reported many sensory details, spoke about their memories more from a first-person perspective and reported more positive feeling and less negative feeling when asked to retrieve a memory. The researchers also found that depressive symptoms had little effect on the ability to recall vivid details in memories, suggesting that the connection between life purpose and memory recall is not due to the fewer depressive symptoms among individuals higher in purpose. Purpose in life has been consistently associated with better episodic memory, such as the number of words retrieved correctly on a memory task. This latest research expands on those connections to memory by showing a correlation between purpose and the richness of personal memory. "We chose to measure the ability to recall memories associated with the COVID-19 pandemic because the pandemic is an event that touched everyone, but there has been a wide range of experiences and reactions to it that should be apparent in memories," said co-author Martina Luchetti, an assistant professor in the College of Medicine. Along with the association with better memory, previous research has found other numerous benefits connected with having a sense of purpose, from a lower risk of death to better physical and mental health. "Memories help people to sustain their well-being, social connections and cognitive health," said co-author Antonio Terracciano, a professor in the College of Medicine. "This research gives us more insight into the connections between a sense of purpose and the richness of personal memories. The vividness of those memories and how they fit into a coherent narrative may be one pathway through which purpose leads to these better outcomes.   Vitamin D protects against severe asthma attacks Queen Mary University of London, October 3, 2021 Taking oral vitamin D supplements in addition to standard asthma medication could halve the risk of asthma attacks requiring hospital attendance, according to research led by Queen Mary University of London (QMUL). Asthma affects more than 300 million people worldwide and is estimated to cause almost 400,000 deaths annually. Asthma deaths arise primarily during episodes of acute worsening of symptoms, known as attacks or 'exacerbations', which are commonly triggered by viral upper respiratory infections. Vitamin D is thought to protect against such attacks by boosting immune responses to respiratory viruses and dampening down harmful airway inflammation. The new study, funded by the National Institute for Health Research, and published in The Lancet Respiratory Medicine, collated and analysed the individual data from 955 participants in seven randomised controlled trials, which tested the use of vitamin D supplements. Overall, the researchers found that vitamin D supplementation resulted in: a 30 per cent reduction in the rate of asthma attacks requiring treatment with steroid tablets or injections - from 0.43 events per person per year to 0.30. a 50 per cent reduction in the risk of experiencing at least one asthma attack requiring Accident and Emergency Department attendance and/or hospitalisation - from 6 per cent of people experiencing such an event to 3 per cent. Vitamin D supplementation was found to be safe at the doses administered. No instances of excessively high calcium levels or renal stones were seen, and serious adverse events were evenly distributed between participants taking vitamin D and those on placebo. Lead researcher Professor Adrian Martineau said: "These results add to the ever growing body of evidence that vitamin D can support immune function as well as bone health. On average, three people in the UK die from asthma attacks every day. Vitamin D is safe to take and relatively inexpensive so supplementation represents a potentially cost-effective strategy to reduce this problem." The team's use of individual participant data also allowed them to query the extent to which different groups respond to vitamin D supplementation, in more detail than previous studies. In particular, vitamin D supplementation was found to have a strong and statistically-significant protective effect in participants who had low vitamin D levels to start with. These participants saw a 55 per cent reduction in the rate of asthma exacerbations requiring treatment with steroid tablets or injections - from 0.42 events per person per year to 0.19. However, due to relatively small numbers of patients within sub-groups, the researchers caution that they did not find definitive evidence to show that effects of vitamin D supplementation differ according to baseline vitamin D status. Professor Hywel Williams, Director of the NIHR Health Technology Assessment Programme, said: "The results of this NIHR-funded study brings together evidence from several other studies from over the world and is an important contribution to reducing uncertainties on whether Vitamin D is helpful for asthma - a common condition that impacts on many thousands of people worldwide." Dr David Jolliffe from QMUL, first author on the paper, added: "Our results are largely based on data from adults with mild to moderate asthma: children and adults with severe asthma were relatively under-represented in the dataset, so our findings cannot necessarily be generalised to these patient groups at this stage. Further clinical trials are on-going internationally, and we hope to include data from them in a future analysis to determine whether the promise of today's results is confirmed in an even larger and more diverse group of patients."     Study Shows Lifestyle Choices Have Significant Impact on Multiple Chronic Conditions, Significant Implications For Reducing Costs Yale University,  October 05, 2021 In a study published in the Journal of Preventive Medicine, Adams and colleagues showed a linear association between a number of modifiable risk factors and multiple chronic conditions, making those modifications a key to health care cost savings and to preventing a wide range of conditions. The data analyzed for the study, https://authors.elsevier.com/a/1VpFeKt2pmc9H, were from the publicly available 2013 Behavioral Risk Factor Surveillance System and included 483,865 non-institutionalized US adults ages 18 years old or older. Chronic conditions included asthma, arthritis, heart disease, stroke, chronic obstructive pulmonary disease (COPD), cognitive impairment, cancer other than skin, and kidney disease. Risk factors included obesity, current smoking, sedentary lifestyle, inadequate fruit and vegetable consumption and sleeping other than seven to eight hours, while depression, hypertension, high cholesterol, and diabetes were considered in each category. Previous research by Thorpe and colleagues had estimated that the care of adults with four or more chronic conditions (17.1% of all adults in the study) is responsible for 77.6% of all health care costs in the U.S. today. The potential savings by reducing just two risk factors (diabetes and hypertension) and their related comorbidity was estimated previously by Ormond and colleagues at $9 billion annually over one to two years and closer to $25 billion a year after 5 years or more, factoring in possible complications. True Health Initiative founder, at Yale University  Director and study co-author David L. Katz, MD, MPH, FACLM, pointed out that in addition to costs, another implication of the study results is an individual's access to healthcare if they have one or more of the chronic conditions. "Although insurers decide what qualifies as a pre-existing condition, all the chronic conditions used in this study except cognitive impairment are commonly included," he said. "Individuals with a pre-existing condition could be denied coverage or face higher premiums. While having a pre-existing condition might not affect coverage for adults eligible for Medicare, over half of all adults with multiple chronic conditions are ages 18 to 64 years." American College of Lifestyle Medicine President George Guthrie, MD, MPH, FACLM, said the study confirms the necessity for addressing the root cause of chronic conditions. "The evidence shows that the risks for chronic disease are rooted in lifestyle choices," he said. "More than ever, it is important to emphasize lifestyle medicine as the first treatment option for preventing, treating, and in some cases, reversing the cause of chronic conditions. If we can help people with chronic conditions, we can add years to their life and life to their years, as well as lower the ever-increasing costs of healthcare for everyone."     Physical athletes' visual skills prove sharper than action video game players University of Waterloo (Canada), October 7, 2021 Athletes still have the edge over action video gamers when it comes to dynamic visual skills, a new study from the University of Waterloo shows. For an athlete, having strong visual skills can be the difference between delivering a peak performance and achieving average results. "Athletes involved in sports with a high-level of movement—like soccer, football, or baseball—often score higher on dynamic visual acuity tests than non-athletes," said Dr. Kristine Dalton of Waterloo's School of Optometry & Vision Science. "Our research team wanted to investigate if action video gamers—who, like e-sport athletes, are regularly immersed in a dynamic, fast-paced 2D video environment for large periods of time—would also show superior levels of dynamic visual acuity on par with athletes competing in physical sport." While visual acuity (clarity or sharpness of vision) is most often measured under static conditions during annual check-ups with an optometrist, research shows that testing dynamic visual acuity is a more effective measure of a person's ability to see moving objects clearly—a baseline skill necessary for success in physical and e-sports alike.  Using a dynamic visual acuity skills-test designed and validated at the University of Waterloo, researchers discovered that while physical athletes score highly on dynamic visual acuity tests as expected, action video game players tested closer to non-athletes.  "Ultimately, athletes showed a stronger ability to identify smaller moving targets, which suggests visual processing differences exist between them and our video game players," said Alan Yee, a Ph.D. candidate in vision science. All participants were matched based on their level of static visual acuity and refractive error, distinguishing dynamic visual acuity as the varying factor on their test performance. These findings are also important for sports vision training centers that have been exploring the idea of developing video game-based training programs to help athletes elevate their performance. "Our findings show there is still a benefit to training in a 3D environment," said Dalton. "For athletes looking to develop stronger visual skills, the broader visual field and depth perception that come with physical training may be crucial to improving their dynamic visual acuity—and ultimately, their sport performance."  The study, Athletes demonstrate superior visual dynamic visual acuity, authored by Waterloo's School of Optometry & Vision Science's Dalton, Yee, Dr. Elizabeth Irving and Dr. Ben Thompson, was recently published in the journal Optometry and Vision Science.     Probiotic Akkermansia muciniphila and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption University of Oviedo (Spain), September 8, 2021 Nonalcoholic steatohepatitis (NASH) is one of the most prevalent diseases globally. A high-fat, high-cholesterol (HFHC) diet leads to an early NASH model. It has been suggested that gut microbiota mediates the effects of diet through the microbiota–gut–brain axis, modifying the host's brain metabolism and disrupting cognition. Here, we target NASH-induced cognitive damage by testing the impact of environmental enrichment (EE) and the administration of either Lacticaseibacillus rhamnosus GG (LGG) or Akkermansia muciniphila CIP107961 (AKK). EE and AKK, but not LGG, reverse the HFHC-induced cognitive dysfunction, including impaired spatial working memory and novel object recognition; however, whereas AKK restores brain metabolism, EE results in an overall decrease. Moreover, AKK and LGG did not induce major rearrangements in the intestinal microbiota, with only slight changes in bacterial composition and diversity, whereas EE led to an increase in Firmicutes and Verrucomicrobia members. Our findings illustrate the interplay between gut microbiota, the host's brain energy metabolism, and cognition. In addition, the findings suggest intervention strategies, such as the administration of AKK, for the management of the cognitive dysfunction related to NASH. In this study, we described cognitive, brain metabolism, and microbiota alterations associated with high-fat and high-cholesterol consumption. In addition, we clearly showed that environmental enrichment and A. muciniphila CIP107961 restore cognitive dysfunction. Furthermore, we revealed that cognitive improvement is associated with differential effects of environmental enrichment and this strain of A. muciniphila on brain metabolism and gut microbiota. Finally, we discovered that restored cognitive function was associated with the administration of A. muciniphila CIP107961, but not L. rhamnosus GG, which may be clinically relevant when selecting probiotics for treating HFHC-derived pathologies. In conclusion, the microbiota and cognition are intimately connected through the gut–brain axis, and in HFHC pathologies they can be influenced by environmental enrichment and A. muciniphila CIP107961 administration. Cognitive improvement was accompanied by changes in brain metabolic activity and gut microbial composition analysis, pointing to specific microbiota targets for intervention in diet-induced pathologies. However, some mechanisms other than major changes in microbiota composition and the combined effect of environmental enrichment and A. muciniphila administration, which we identified in this study, may also be biologically relevant and will need to be investigated in future studies due to their relative contributions to the selection of effective treatments for patients.           

The Mark Thompson Show Podcast
October 7, 2021: LA Times' Michael Hiltzik: We learned nothing from previous oil spills. Will we learn from this one?

The Mark Thompson Show Podcast

Play Episode Listen Later Oct 7, 2021 14:57


Michael Hiltzik, Pulitzer Prize-winning journalist & business columnist at the LA Times. See omnystudio.com/listener for privacy information.

Doug.Show by Niche Site Project
Technical SEO Audit UPDATE – Olga Zarzeczna – seosly.com – DS291

Doug.Show by Niche Site Project

Play Episode Listen Later Oct 7, 2021 57:12


Get an update from Doug after he implemented some of the changes recommended by Olga after her Audit of NSP! Previous interview with Olga: Technical SEO Audit for Niche Site Project (with Olga of seosly.com) DS245 Connect with Olga: Seosly Twitter LinkedIn This episode is brought to you in part by Ezoic.  And be sure to check out Leap to help your site load faster. Plus you won't have to worry about the Core Web Vitals. Contact me. Ask Questions! Send me an email here: feedback@doug.show Leave a voicemail: (406) 813-0613

Winning Ponies
WP Welcomes Back Comm. Assoc. Amy Owens & Handicapper Byron King

Winning Ponies

Play Episode Listen Later Oct 7, 2021 56:23


With less than five weeks to go before the Breeders' Cup Championships, this weekend is busiest of the North American season for the win and you're in races. 11 qualifiers are on the calendar, mostly at Keeneland where we will put the focus of this week's show. Amy Owens logs a lot of miles every morning traveling from barn to barn to find stories of interest and check in on the many stakes horses – before and after the races. As always, a new Keeneland meet brings in new creative ideas to the game and Amy will update us on all of them and the schedule of events for the Fall Meet. One eye-catching concept is the new Keeneland Turf Pick 3, for handicappers of all levels during the Fall Meet from Oct. 8-30. The Keeneland Turf Pick 3 wager will be offered on the final three turf races each race day. The minimum wager is $3 and will follow the same rules as the traditional Pick 3. The new wager has a 15% takeout, the same low takeout as Keeneland's popular Pick 5 wager. As Keeneland Communications Associate, Amy Owens assists Keeneland's Communications Department with a variety of projects related to races and sales. Kentucky native Byron King will be on-site at Keeneland to cover the action for The Blood-Horse and perhaps make a wager or two. He'll be joining John to analyze as many “Win and You're In” races as time allows. The action starts on Friday and features a packed field in the G1 $400,000 Darley Alcibiades for 2-year-old fillies. This race not only delivers a Breeders' Cup berth, but points for next year's Kentucky Oaks. Previous to that race on the card the race will be to the swift in the six furlong G2, $250,000 Stoll Keenon Ogden Phoenix. Saturday is a stakes-filled afternoon and will see the juvenile boys match strides in the G1, $500,000 Breeders Futurity with an overflow field. In addition to Breeders' Cup invite, the race carries qualifying points to the Kentucky Derby. Thirteen outstanding fillies and mares will take to the turf on the card in the G1, $400,000 First Lady Stakes that should provide excellent betting opportunities.

Business Innovators Radio
Interview with Andrew Saksa Senior Vice President of the Financial Services Division at ReminderMedia.com

Business Innovators Radio

Play Episode Listen Later Oct 6, 2021 16:59


Andrew is a media marketing and business development expert.ReminderMedia.com is a Philadelphia-based media and marketing firm currently ranked Philly Top 100 and Inc. 5000 Magazine fastest-growing companies two years consecutively. His primary roles include Enterprise/Global and National Business Development.Previous to ReminderMedia, he Co-Founded MyPistevo a mobile application for criminal background checks and was instrumental in structuring alliances with IDateUS, MateSafe, Houston Social, AmberNealPresents, SinglesofFaith, and Elitemate. From 2010-2015, Andrew has volunteered as a Grief facilitator for New Hope for Kids in Maitland, Florida a nonprofit organization that helps grieving children and surviving spouses with the loss of a parent or spouse.Learn More: https://remindermedia.com/financial/*Get a 67% discount and Plus get 15 FREE magazines! https://remindermedia.com/authorityInfluential Influencers with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-andrew-saksa-senior-vice-president-of-the-financial-services-division-at-remindermedia-com

Influential Entrepreneurs with Mike Saunders, MBA
Interview with Andrew Saksa Senior Vice President of the Financial Services Division at ReminderMedia.com

Influential Entrepreneurs with Mike Saunders, MBA

Play Episode Listen Later Oct 6, 2021 16:59


Andrew is a media marketing and business development expert.ReminderMedia.com is a Philadelphia-based media and marketing firm currently ranked Philly Top 100 and Inc. 5000 Magazine fastest-growing companies two years consecutively. His primary roles include Enterprise/Global and National Business Development.Previous to ReminderMedia, he Co-Founded MyPistevo a mobile application for criminal background checks and was instrumental in structuring alliances with IDateUS, MateSafe, Houston Social, AmberNealPresents, SinglesofFaith, and Elitemate. From 2010-2015, Andrew has volunteered as a Grief facilitator for New Hope for Kids in Maitland, Florida a nonprofit organization that helps grieving children and surviving spouses with the loss of a parent or spouse.Learn More: https://remindermedia.com/financial/*Get a 67% discount and Plus get 15 FREE magazines! https://remindermedia.com/authorityInfluential Influencers with Mike Saundershttps://businessinnovatorsradio.com/influential-entrepreneurs-with-mike-saunders/Source: https://businessinnovatorsradio.com/interview-with-andrew-saksa-senior-vice-president-of-the-financial-services-division-at-remindermedia-com

Work From The Inside Out
145: Don't Discount Your Previous Experience - Elaine Bennett

Work From The Inside Out

Play Episode Listen Later Oct 6, 2021 47:22


Strategic messaging consultant Elaine Bennett never thought of writing as a career even though she had a teacher in high school who ushered her toward an extracurricular class on writing stating, “You're going to be a writer”. Elaine had no intention of becoming a writer. She went off to college, majored in theater with the goal of moving to New York and becoming a director. Arriving in New York, Elaine relied on a skill she had developed in fifth grade, typing. As much as she abhorred it, it eventually opened up some work opportunities that she never would have imagined. Elaine ended up at Salomon Brothers as a temp. ​​She also found work as a sound and light runner for some Off-Broadway shows. Elaine joined a theater group where she directed staged readings of new plays and while it was enjoyable, she wasn't making the professional progress that she wanted to. At that point, she was also doing some writing for herself, pitching articles, and discovered that she loved editing, and copy editing. One day while temping at Salomon Bros., Elaine was sent up to the CEO's office to write a speech for him on the spot. Gulp … From there, she was offered a permanent role as the CEO's speechwriter. When scandal forced the executive to resign, Warren Buffett stepped in as interim CEO. Elaine's new boss, Mr. Buffett offered her one of his highest compliments, “You have a terrific ear, and you turn straight thinking into straight writing.” And that's what she's been doing ever since, melding the mind of a business person with the sensibility of an outsider to tell complex stories in a sophisticated but relatable way. Elaine advises clients from Fortune 50 CEOs to entrepreneurs on their messaging. In this week's Work From The Inside Out podcast, learn more about Elaine's  journey: Elaine creates and delivers training on how to improve the writing of everything from internal communications to speeches.    Her 2019 TEDx talk tackles the topic of how language can change the world.    Learn more and connect with Elaine here:  https://www.facebook.com/BennettInkWriteNow https://www.facebook.com/elaine.bennett.31/ @bizspeechwriter https://www.bennettink.com

Build Your House Yourself University
Questions For Your Contractors' References— Ask Your Contractors' Previous Clients These Things— BYHYU 240

Build Your House Yourself University

Play Episode Listen Later Oct 6, 2021 18:05


As you probably know, a major part of doing our due diligence and vetting or investigating a contractor before hiring him or her is to contact some references.   Ask the contractors you're considering for your project for ideally at least 3-4 references.  And make sure you actually contact those references.  Most people are very willing to help out by chatting about their homes and construction experiences.  Some people think contacting references is not very helpful because they think the contractor will only give a list of their best customers who may potentially be unwilling to share anything other than the most positive remarks.  But you'd be surprised by how honest people will be, especially if the contractor is not in earshot of their comments.  Plus, my list of questions will hopefully elicit candid, valuable information.   Show notes at BYHYU.com www.facebook.com/BYHYU

Real Life Real Crime

In this episode, Woody from his career about a rape and the details that follow as well as thanks all LIFERS for their votes! Woody WON the People's Choice Podcast Award for BEST MALE HOST!!!!! Real Life Real Crime is proudly sponsored by: This week: Canva: Design like a pro with Canva Pro! Right now, you can get a FREE 45-day extended trial when you use my promo code! Just go to canva.me/rlrc to get your FREE 45-day extended trial. Previous weeks: Talkspace Start feeling better with a single message- Match with a licensed therapist when you click the link and get $100 off your first month with the promo code REALCRIME ZocDoc :Sign up for free today! Never wait on hold for a receptionist again! Everyplate: Get started with EveryPlate for just $1.99 per meal by going to EveryPlate.com entering code rlrc199 Athena Club: Show your skin you care with the Athena Club Razor Kit! Sign up today and you'll get 20% off your first order! Just go to AthenaClub.com and use promo code rlrc. ______________________________________________________________________________________________________________ We ask for the continued support of the Coco family as they go through this next chapter. We ask that you continue to call in tips about Barbara Blount @225-395-1302 or use the TIP button on Real Life Real Crime, the app. Want more episodes? Download our app in the app store or Google Play and listen straight from the app! Follow us on: INSTAGRAM: @REALLIFEREALCRIME, @OVERTONWOODY Twitter: @reallifecrime Contact us: For Business Inquiries ONLY, please contact cyndi@realliferealcrime.com Real Life Real Crime proudly supports: LOPA- Woody Overton is a huge supporter of LOPA. Just listen to his podcast and you will hear him mention it at the end of each episode. Please take the time to click the LOPA link and REGISTER. It takes 2 minutes and just 1 donor can save up to 8 LIVES! Real Life Real Crime held a raffle which raised over $8,000 for LOPA in a few short weeks. The raffle was sponsored by Duvalle's Cajun Charters, Jim Chapman, Local Leaders: The podcast, Tiffany Sicard of HomeKey Mortgage and Real Life Real Crime. We all look forward to this years raffle that will be amazing! Our goal is to double last years number! Merakey Gateway is near and dear to Real Life Real Crime. This transition service provides comprehensive transition training for individuals diagnosed with autism and related orders as they transition into a life of greater independence. Their programs work with the individual to identify personal goals and create a plan to accomplish their dreams. Whether an individual wants to get a job, go to college, or just become more independent, the Gateway team can assist with an individualized pathway to success. The transition plan will include skills related to employment, community life, housing, finances and independent living. Gateway Ink is a social enterprise screen printing business which trains and employs participants as they learn vocational skills. Their Shop Manager and Program Director work together in developing individual training techniques and identifying accommodation needs for the participant to bring into their future careers. Orders placed through Gateway Ink, support our programming financially as well as provide a job for our participants looking to build their skills and reach their goals Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

VO BOSS Podcast
Voice and AI: Descript

VO BOSS Podcast

Play Episode Listen Later Oct 5, 2021 35:22


If you can dream it, it can happen! Jay Leboeuf from Descript joins Anne to discuss the benefits of having a voice clone and how Descript can improve work-from-home potential for talent. Remove filler words with one click, adjust your audio via transcript, fix errors using an Overdub voice clone, and so much more. Use your voice beyond its in-person potential with tools that bring the power of AI editing directly to talent. More at https://voboss.com/voice-and-ai-descript-jay-leboeuf/ Transcript >> It's time to take your business to the next level, the BOSS level! These are the premiere Business Owner Strategies and Successes being utilized by the industry's top talent today. Rock your business like a BOSS, a VO BOSS! Now let's welcome your host, Anne Ganguzza. AI Voices: Welcome to the podcast. The VO BOSS podcast blends solid, actionable business advice with a dose of inspiration for today's voiceover talent. Each week host Anne Ganguzza focuses in on a specific topic to help you grow your voiceover business. Anne: All right. Hey everyone, who was that? That was some other people introducing the podcast today. So welcome again, everyone to the VO BOSS podcast. This is the AI and Voice series, and I am your host Anne Ganguzza, Anne Ganguzza. Today, I'm excited to bring you special guest Jay LeBoeuf, head of business development at Descript, a company that creates tools for new media creators. Now, Jay is also a lecturer on media technology and business at Stanford University, Carnegie Mellon, and University of Michigan, and sits on the board of advisors of numerous AI media and ed tech startups. He previously worked at some little known companies, probably to you guys out there and in the voiceover world, Avid Pro Tools and Izotope. Jay, thank you so much for joining me today. Jay: Thanks for having me, Anne. It's, uh, it's wonderful to be here with some of my AI-driven voice friends. Anne: Yeah, that was fantastic. So what we heard in the beginning was a couple of your voices on your platform, right? Jay: Indeed. One of which is my own and we were using Descript's Overdub technology. Anne: Awesome. Well, I want to definitely talk to you about that, but before we get into your role at Descript and what the company offers, first of all, let me just say, okay. Avid Pro Tools and Izotope, known to just everybody probably that listens to this podcast, and your resume is so incredibly impressive. Back in 2008, you were founder and CEO of Imagine Research where you created the first sound object recognition platform. And somehow that, I believe that that led into a patent as well as some small business research awards to you. And then somehow that became Izotope in 2012. Now, does that mean that my mouse clicks are being detected by an AI engine? Jay: So there's so many ways that AI is now integrated into the creative products that we use on a daily basis. And so the short answer is yes. So Imagine Research was based on some of what I was seeing. So I was at the, on the Pro Tools team, like you mentioned for about eight, eight and a half years before that. And I was seeing all these struggles that recording engineers, mixing engineers, voiceover talent, uh, ADR, we were seeing all these, these problems in the process that AI could solve. So we attempted to create the first set of tools where we could teach a computer how to recognize basic sounds and musical instruments, and even robustly differentiate is this a male speaker versus a female voice, and, you know, try to choose presets automatically for it. So Izotope acquired that company and that technology. I was at Izotope for about two years or so, helping to integrate all that work. And you know, you now see that Izotope products include a number of assistants -- Anne: Oh yeah. Jay: -- and things that will listen to your content and it's going to help it -- Anne: Absolutely. Jay: -- get it to the next stage. And that's the goal with all of this. Anne: And I have to say that there's a lot of people in the voiceover industry that just absolutely, that is their go-to, that is their go-to product to get rid of excess noise in their recording. So I thought that that was so fascinating. So, and now you are at Descript, and I've heard of Descript from the podcast world, and I'd heard about it a few years back where a lot of people were starting to use Descript for transcripts for their podcasts. And then wow, you guys just seem to have like catapulted with your product offerings since then. Tell us a little bit about Descript and the products that you offer, because I'm genuinely impressed with everything that you guys have going on over there. Jay: Great. Uh, thanks for using it, being familiar with it. For those that don't know De-script or Descript, we have no official pronunciations. So the choice is yours. Anne: Okay. Jay: Our team is kind of split on it. I go with De-script myself. So -- Anne: De-script. 4:30 Jay: Descript allows creators to create and edit audio and video as simply as typing. And this is this paradigm where you can drag in content that you've recorded externally, or you can record natively in the app. A transcript appears in seconds to minutes. You know, this time transcript will appear. If you have multiple people on a track, will automatically detect who they are, split them into different speaker labels. So you have this like really rich transcription going on. And a lot of people might stop right there and say, yeah, I've seen transcription tools before. Then I, you know, do a paper edit in Google docs, and then we bring it into Pro Tools and then just start cutting. But with Descript, we have all this alignment technology where the transcript is automagically aligned to the underlying audio and video. So as you are editing the text, as you are doing things like cutting out all of your ums, ahs, likes, you knows, all of that, just snips them out. And we use some AI to kind of stitch it all together. So that way you make a few cuts. And I have plenty of examples I can play of like befores and afters, where we can take a lot of great material and just make it sound so much better. So that's all you have to do, just edit text. Anne: Now I remember when I looked at it a couple of years ago, one of the things that I have today is when I record through ipDTL, because it's a high quality audio connection, people can talk over one another. And whenever I tried transcript technologies in the past, it couldn't deal with people talking at the same time, and then basically separating out who they were. But I feel like your technology has now surpassed those issues. And it's really something that I think is incredible, that it can even overlay the words on the wave form. Is that what you had mentioned? Jay: Absolutely, so you have, you have two ways of editing. You have the script view where you can actually just see the transcript. And if you just, all you want to do is select words and phrases and hit, delete, or strike through, you can edit through that. But if you are more comfortable with the wave form, we actually will overlay the words on top of each part of the wave form. Anne: Wow. Jay: And then you can make your manipulations there. So if you want to add a crossfade to a certain place, you know that, okay, yeah. Just put a crossfade between the words, voiceover and business, and no more needing to audition thousands and thousands of times to get them right. Anne: Wow. Well, that's fantastic. All right. So that's for podcasting. And now you have some other products that you offer as well that are quite powerful. Jay: Exactly. So, you know, we're most known for podcasting, I'd say. You know, the, the people in that community have probably heard of us, have probably tried it out. If you haven't, by all means, now's a great time to at least try. Drag some tape in, start cutting it up, and of course if there's anything I can help you with, let me know. But you know, we added video support in 20 -- what year are we in now -- 2020. Anne: Yep. I saw that. Jay: It's been a year. Anne: It's been a year. Jay: It's been a year. So about halfway through 2020, we -- you were always able to kind of edit the video because it was always linked to the audio, but we really doubled down. So, uh, what we ended up doing was built in all of the basic features that you would have in a typical non-linear editor, like an, an iMovie or a Final Cut or a Premiere. We built in all the basics, all the bread and butter things that you need, on top of all of the word and text editing capabilities we had. So you can now do all of your cross fades, all of your titling, arrows and annotations, and you know, very basic multicam support. All these things work great, 4k, 60 frames-a-second video. It's all synced to the cloud, so that's something that's also really wonderful about the tool, and you, and I could record something. I can invite you just like a Google Doc, and then you and I can start collaborating on this material simultaneously. We see the same doc. We have the same footage. Anne: So, wow, a video word processor. So we have the audio word processor -- Jay: Video word processor. Anne: -- and now a video word processor. That's, wow. Also, in addition to that, I think you can do screen recording as well with Descript? Jay: Exactly. So for all of us that are fully embracing the remote collaboration -- Anne: Yeah. Jay: -- asynchronous video communication life, we're sending each other a lot of quick updates or quick tutorials. So rather than have to type out those "here's all the instructions on how to connect to ipDTL for the first time," you can actually just do a quick screen recording using your own voice. And what differentiates the Descript screen recorder is again, as soon as you finish recording your screen recording, either, you know, your webcam or the screen itself, you see an instant transcript of what you said. And with one click, if you want to remove all of your filler words -- Anne: Right. Jay: -- I am a prolific ummer and ahher when I'm making stuff up. Anne: We all -- yeah, I think we all. We all are. Jay: So when -- you get to this little dialogue that pops up that says you have 35 filler words -- Anne: Wow. Jay: -- click to remove, and then you'll see the sentence where I start explaining it. And then I say, "yeah, let me try that again." I can just whack that sentence out and then send the video along. You can ask my team. I do tons of those every day,. Anne: Now does it record the screen, and also use the video cam? So it can do multiple cameras or multiple recordings at the same time? Jay: Exactly, exactly. So, so right now you can have your webcam as a bubble that you can position anywhere you want on the screen. Also, you have separate audio tracks for your mic. You have computer audio. So that's something that I use a lot where I'm demoing something and maybe sharing the output of Descript to the app or a different tool. So you can capture audio from computer audio and also your high input. Anne: Fantastic. Jay: Very nice microphones. Anne: Now I happen to read a press release the other day about a new product called Studio Sound, which allows you to remove noise [laughs] in your recording. Jay: Okay. Anne: That's pretty powerful. [laughs] Jay: So I have incredible admiration for companies that make professional noise reduction, de-reverberation restoration tools. I have a ton of friends that work at Izotope. Having worked there myself, I love the company. So -- Anne: I was going to say, you have quite a background in it. So that would make sense. [laughs] Jay: So I will say what we wanted to build was as close to a one checkbox solution where you know what, you have this audio, you either don't have the time, you don't have the skill -- Anne: Right, exactly. Jay: -- you don't have the knowledge to use the professionals. So like we're not talking about saving location recording from the deadliest catch and removing like -- Anne: Right. Jay: -- some of those conditions. We're talking about -- let me play an example. So I'm going to play you some material, and this, this is maybe what got recorded with some, you know, room tone on a not great mic. So let me just hit play. Anne: Okay. [room noise] Jay: Hey, there's the room tone. Voice: The appearance of the island when I came on deck next morning was altogether changed. Although the breeze had now utterly ceased, we'd made a great deal of way during the night and were now lying becalmed about half a mile to the southeast of the low eastern coast. Jay: Okay. So now let me click a checkbox that's called Studio Sound in Descript. Anne: And that's not uncommon for people with podcasts who have guests that are not necessarily -- Jay: Right. Anne: -- having the right recording studio. Jay: Right. No, definitely. Anne: Yeah. Jay: So now, now let me hit the space bar and now I'm playing. Voice: The appearance of the island when I came on deck next morning was altogether changed. Although the breeze had now utterly ceased, we'd made a great deal of way during the night and were now lying -- Jay: Let me turn it off. Voice: -- becalmed about half a mile to the southeast of the low eastern coast. Anne: Wow. Jay: And back on. Voice: Green colored woods covered a large part of the surface. Anne: Wow, wow! Jay: That's one checkbox. Anne: This is a product that's actually out now? Jay: This is out now. We -- Anne: Wow, that's incredible. Jay: -- have a beta tag applied to it because we're still experimenting with it -- Anne: Sure. Jay: -- but it's actually on every plans. Anne: Okay. Jay: We have a free Descript plan. So people listening to this, they're like, I want to try this out. You can try this out. It's totally free. Try it on your files, download your files when you're done with them. Anne: Right. Jay: We're really excited about this. And this is just one of these other suites of tools that we're trying to do to allow people to create professional sounding and looking content faster than ever before. Anne: Sure. Jay: You shouldn't have to spend hundreds and hundreds of extra dollars to download and learn tools when you have problems with your content. And so that's, that's some of the stuff we're trying to solve. Anne: Yeah, and that really serves a need. You know, I cannot tell you how many people -- I mean, I'm a full-time voice talent. And so for me, you know, this is part of my daily thing. I had to learn how to, or I'd had tools that helped me to remove noise, but there's so many people out and in the podcast world, or just in general, that are creating content and yeah. Stuff like this is it can be immensely helpful. So, wow. So that's an incredible suite of tools, and you also now have, well, you've had it for a couple of years now, Overdub, right, which is your -- this is how you can create an AI voice, your voice cloning technology. Talk to me a little bit about that. Jay: Absolutely. So Overdub allows anyone to create their own voice clone, and importantly, only with their own voice. And you can do that with only a few minutes of training data. And once you have this voice clone, this voice model, you can generate new sentences or correct your verbal typos. So a few ways that we see it being used, being -- really resonate with your listeners. Let's say you made a mistake in a, in an audio book or, you know, in a podcast, you mispronounced the key character's name. Anne: Right. Jay: You stated a date wrong, something like that. So you need to go back to the studio, or if you're at home, you need to kind of set up your equipment again, get it exactly how it was before. Anne: Punch and roll. [laughs] Jay: Rerecord everything, punch and roll, or even better, I have much more experience on the editor side. So as an editor, I would spend hours trying to find that word or phrase and then splice it in from elsewhere in the archives. Anne: Absolutely. Jay: It just never sounds right. Anne: Yeah, that actually makes me think of a lot of medical recordings that I do, for medical narration. If you find that you've mispronounced the word once, it's usually in the script quite a few times, if it's a product name. Jay: Right. So with Overdub, you would have created your own voice model. And so if you have the script and you knew -- you're using Descript, you can actually go in, find that one word that needs fixing or that phrase that needs fixing, or the sentence you actually forgot to say, and just type it in. And what we actually do behind the scenes -- this part is fascinating -- we don't just generate in the word in isolation. We take the text that you type in. We take basically the audio recording before your contextual edit and the audio after. And then we send that all to the cloud, and using those three inputs along with, you know, your voice model, we're able to generate the missing word or phrase to make it fit in in context. So, you know, if I was trying to resynthesize the word Overdub, sometimes it will sound like Overdub. Sometimes it'll sound Overdub, and it's just gonna depend on where it's going to fit in within the phrasing of what you were saying. Anne: Wow. So tell me again, what does it take to create your Overdub again? How long does it take? Jay: As little as 10 minutes -- Anne: Wow! Jay: -- of training data. Anne: So does that mean you have a model that's already there, that's being used for these voices? Jay: So let's go even deeper with the super behind the scenes. The way that we're able to make it so easy where all you need to do is create, you know, you basically read a training script. Anne: Okay. Jay: And you read this training scripts to us, and, you know, we have it on our website and there's, there's nothing special about it. Technically any source material would work, but we just provide this like David Attenborough voiceover stuff. It's really fun to read. Anne: Okay. Jay: So you read that, and we need as little as 10 minutes. The more you add, the better it's going to get. There's no point in going over an hour at that point. Our research has shown it's not going to sound any better. Anne: Okay. Jay: So, you know, between 10 minutes and an hour that you're willing to sit and read this script. The other thing we need of course is your voice consent statement. So this is a 30-second long blurb we also have available on our website, which you grant consent to Descript to create your own voice model. And you're just stating that, like, I and I alone have access to this voice model. If I choose to grant it with somebody else, then I'm giving people the option to use my voice. But you know, this voice is just mine. And we use that to compare against the training data to make sure that this is really you. Anne: Got it. So then let me just back up just a second. Jay: Yeah, please. Anne: So if you're using any of the material that people upload, let's say, for podcast editing or any of the, any of the products that you offer, is any of that being used for training data from Descript? Jay: No. So all of your material, all your voice data is yours and yours alone. Anne: Got it. Previous to releasing Overdub, we had actually learned from this the general speech patterns from thousands and thousands of speakers. Uh, Descript acquired a company called Lyrebird in 2019. Anne: Yes, I'm familiar with that. Jay: And they're real pioneers in this space. And they had actually learned from thousands of existing speakers. Anne: I heard the viral thing they did with politicians, so back a few years back. Absolutely. And so you've had the model for a while that's been developed with thousands and thousands of voices. Jay: Exactly. Anne: Got it. Jay: What, what the secret sauce is, is the ability to, with just a few minutes of a different person's speech, be able to identify what makes Jay or what makes Anne sound the way they do with the mic they have in the room that they do with the cadence that they're speaking? And we kind of can make this like lighter weight model to generate your speech. Anne: Okay. So what, in your opinion, or what, in your knowledge, what makes a better AI voice? Is it the person that records being, I don't know, more conversational or what makes some voices sound a little more robotic than others? Jay: The short answer is it's really going to depend on the underlying technology that's being used. So that's why Descript's Overdub technology sounds different than Alexa, than Google Wavenet, than Thimble, than, you know, than other solutions. For our approach, some of the things that we think makes it sound so good, so one thing is that we are one of the only solutions that actually we generate already 44,100 samples every second of your voice. And your listeners know what that means. If, if people don't it's, you know, CD quality sound -- you don't even know what CDs are anymore. Anne: I know! Jay: It's really good, super high resolution. And so that's one of the things that people often notice, like Alexa is nowhere even close to -- Anne: Right. Jay: 44.1 K. And so that's why she'll always sound that little bit muffled, that little bit like flat. And so by generating in, you know, what the researchers called super resolution, that's one thing that really makes a very big difference with what we're doing. From a training material standpoint, when we, you know, when we work with artists and celebrities, sometimes we'll actually coach them on, you know, the training material that they should put into the system should be read as naturally -- Anne: As possible. Jay: -- as they want the output to be. So, yeah. So, you know, we have the David Attenborough scripts, but if you're never going to be doing that in the wild and then read it in a way that's more representative -- Anne: In the wild! [laughs] Right, right, absolutely. Jay: Literally in the wild. Anne: Yup. Yup. Okay. All right. That makes sense. Now, do you have tools that allow you to change the sound of it once you've, you know, once you've typed in a script, and you change -- can you add emotion? Can you change speed? Those sorts of things? Jay: Change style is what we have. Rather than exposing 10, 15, you know, sliders, controls, checkbox, the Descript way of doing it is to allow you to actually select some source material that sounds representative of the style you want to recreate. So I would go in there, I would highlight a sentence or part of a paragraph that sounds like what I want to create. I would then right click on it, say overdub voice style, and I would say "create new voice style," and then call it whatever you want. So maybe it's happy or enthusiastic. Anne: Okay. Jay: You give it a name and then that name can be applied for Overdub generation in the future to steer the material. Anne: Are you recording that happy? Or are you recording that? Like, where are they getting that from? Where are you getting the happy from? Or the emotion from? Jay: Yeah. Anne: The style. Jay: We leave it to users. Anne: Oh, okay. Jay: That's one of the things people say like -- Anne: I got it. Jay: -- "hey, you know, I just created my voice model. Why don't you provide some templates?" I'm like, because I don't know what you sound like when you're happy. Anne: Okay, okay. Jay: So you get one default style -- Anne: Okay. Jay: -- that the system thinks is neutral Anne. This is what neutral Anne sounds like. And then it's up to you to go through, and in your training data, start finding examples of here's me being contemplative, here's me being excitable, and then give them the names -- Anne: Okay. Jay: -- that you you feel comfortable with. Anne: Do you resell these voices? Jay: No. So your voice is only your voice. You can assign it to other people that you work with on your team -- Anne: Okay. Jay: -- but you can also revoke that at any time. That's, uh, you know, it's functionality that we, we treat seriously. Now that -- the one thing we do provide to get people started out of the box, when we were playing the welcome to the VO BOSS intro, for example, we provide some stock voices. So we have eight right now, just a very limited palette, but still eight stock voices, which are pre-trained voice models of voice actors that we have an agreement with to get people get up and running. Anne: Got it. So then if I wanted to resell my voice, is that possible? Like if I create, let's say I get a script, I mean, you can hire human Anne or you can hire AI Anne. And so somebody says, well, I'm going to hire AI Anne, and I'm going to pay a certain amount. You know, probably not as much as human Anne. Could I then on Descript generate that voice and sell that? Jay: Yeah, we, you know, we don't have a marketplace or anything like that to facilitate that, but -- Anne: Interesting. Jay: -- the voice is yours. So you would come to an arrangement. You would be responsible for sharing your voice with another Descript user and overseeing how they're using it. And you know, the nice part of the voice ownership, you can turn it off at any time, so you can revoke access. Anne: So I guess my question would be, let's say I have a client, and they say, you know what? I have a bunch of material that I need to have recorded, but my budget is so much. And I say, okay, well, I can do that for you with my AI voice. 'Cause I don't have enough time to go in my studio and record that, but I could go to Descript, throw in the scripts, generate that, and then sell that to my client. I guess that's my question. Um, and that would be in agreement -- Jay: Oh, totally. Anne: -- that would be in agreement. How interesting, because I think one thing that a lot of people in the voiceover industry have been fearful of is, you know, who owns that voice, and how do I know where it's being used, and how do I, you know, is there an agreement, a contract that's been drawn up? So what that would do is it would allow us control over our own voice in selling the voice. So we would like, we normally do, we have contracts where we specify usage. So if it happens to be, let's say, in the commercial realm, and it's a commercial for McDonald's, if that's, you know, what they were looking for, we could then, you know, put in usage that would be appropriate for the job. And it would be something that we would negotiate with the company. Jay: Right. Anne: And that would be fine. You're not even a middle guy in that. That's basically we own our own voice. Jay: No. Anne: We can do whatever we want with it. Right? We can download it, right, I assume. Jay: Absolutely. This is the workflow I heard you say, Anne, is maybe we can flip it. You hire me, I'm voice talent. You give me the script. Anne: Yup, yup. Jay: But then like, oh, this is not within my budget. And you're like, how about this? I'm going to give you AI Jay. Anne: Yup. Jay: You're only interested in the final files. Maybe I can also give you the Descript file so that way, if you need to make -- Anne: Changes. Jay: -- changes and tweaks, you can, but you can't make, you can't generate new material. Anne: Well, then they'd have -- Jay: So here's AI Jay. This is Jay. I'm reading a sentence for Anne. She paid me to read this. Here you go. Anne: Oh, yup, yup. Jay: There's my material. You provide the audio files. These things are getting a lot of traction. So we actually have the ability to batch export material. And also we have API access for -- Anne: Wow. Jay: -- Overdub for if you want to programmatically do things. Anne: Sure. Jay: So a real example, there's a -- Anne: Wow. Jay: -- creative agency, and they work with one of their voice actors to do a mixture of things that are read real, but then they have a contract with Sunglass Hut. And they want to personalize it to go to your local Sunglass Hut. Anne: Right, exactly. Jay: And they get the address or the town. Anne: Sure. Jay: And so what they actually do, and Descript is not involved in this -- Anne: Right. Jay: -- but they use the tools to programmatically then create all the addresses sp this voice talent doesn't have to read 10,000 different Sunglass Hut locations. And so the voice actor consents to using their voice for that. And often they're the ones like generating on their system -- Anne: Sure. Jay: -- because they want to make sure it sounds right, and it's -- Anne: Well, yeah, exactly. So the client isn't necessarily going in -- they don't have a Descript account, and they're going in and typing it -- in addresses. It would be the talent probably, 'cause you're right. They would tweak it speed-wise or, you know, just so it sounds good. Jay: Right. And it's as super flexible. So I would encourage -- Anne: Right. Jay: -- because you know, the voice that you create, you can only create a voice with your own voice. You -- Anne: Right. Jay: We have people that try to upload a Barack Obama voice, you know, try to fake the consent statement, and AI built this. AI is kind of smarter than that. So it can detect that you're trying to fake the system. Anne: Right. Jay: We also have a human in the loop that listens to these consent statements. Make sure everything's legit. Anne: Oh, got it, got it. Jay: So we do everything we can to keep this as secure as possible. Anne: Wow. Talk to us a little bit about ethics, because I know you're one of the early adopters of putting a terms of service and an ethics statement on your website. Tell me about your policies on that. Jay: Yeah. I love that when I joined -- I joined the company at the beginning of 2020. There was already an ethics statement in place -- Anne: Mm-hmm, yup. Jay: -- which, which I was really inspired by. So you own, and you control your use of your digital voice. And this is something we strongly believe in that users can, you know, create a model that's authorized by you and controlled by you. So that's something that we unwaveringly do not budge from, and it's all based on this recorded verbal consent state, that kind of grants consent, and also helps us verify that you are a real, live, consenting person. So we will not clone voices of the deceased. Anne: Okay, okay. Jay: It's just, it's just a slippery slope. Anne: Yeah. Jay: That's an unapproved voice cloning. So unless we have a consent statement,. Anne: Oh, okay, that makes sense then why you have a verbal consent statement, yeah. Jay: We have a verbal consent statement, and, you know, uh, and again, people will try to stitch it together with -- Anne: Sure. Jay: -- with words, but it's just the system's designed to, to try to not allow that. And you know, we personally view that unapproved voice cloning -- like if we start making exceptions to this rule, then we're going to get into a world where we're making subjective judgment calls -- Anne: Yeah. Jay: -- about what's ethical and what's not ethical -- Anne: Absolutely. Jay: -- or what's a creative use case. And that's a very slippery slope. So we just want to be very clear and transparent. You have to own your voice. You have to be able to provide a consent statement. Um, we do not clone voices of children or minors. That's also against our terms of service. So if you're under 13, you can't use Descript. Our terms of service prohibit that. Anne: Okay. Jay: And we really want to stay up on what are the, the latest ethical standards? How are other companies using this? So we're talking to a lot of companies, participating in different membership organizations to try to figure out, you know, how do we ensure that content is authentic and -- Anne: Right. Jay: -- we're, we're as responsible as possible? Anne: Are you in the process of improving your model? So the AI voices will become even better and better and better with even maybe less data or, you know, even more human-like? Or is there a point where you kind of say, this is the level of -- like, how human do you want it to be? Because I think there's a level there of, if it becomes too human, then maybe there's that one note that somebody says, "wait a minute, am I being duped? Is this, you know, is this a human talking to me? Or is it an AI voice?" Do you have a level of, I guess, humanness for your AI model? Jay: We're going to keep improving it until it is indistinguishable from reality. And there's a lot of podcasts right now where you know, the sweet spot right now, Anne, is for this contextual edits where a word or a phrase has been fixed in the context of a longer recording. So we're at the point now where hosts are using that on a regular basis, and you can't tell. Like, no one's writing in and saying -- Anne: Right. Jay: -- that it sounds fake. And that's something that even a few years ago, it sounded like -- Anne: Sure. Jay: -- like voicemail phone tree systems, it would stick out. Those are just smooth. They sound great. Where we're going to be going, and what I think is going to sound better and better in the coming years is this like longer form text-to-speech. Anne: Yeah, right. Jay: So let me give you an example. So this is, this is how Malcolm Gladwell and his team at Pushkin Industries use Descript, and they use this for podcasts and audio books. So, you know, they're using Descripts, the desktop app, to transcribe dozens of interviews and, you know, archive material, and then starting to pull tape, pull selects, and getting the show in like a good rough cut. And then Malcolm Gladwell created his Overdub voice, and he assigned access to his voice to some of his editors. So they can create a draft narration for what the show would sound like with him doing the intro and kind of transitioning between different pieces. And so they can actually do a table read, and everybody can just kind of get on a call, listen to the table read with digital Malcolm, so they can hear how it sounds before anybody entered the -- Anne: Sure. Jay: Now that -- nothing's going to replace Malcolm in the zone saying and introducing his stories as himself. Anne: Right. Jay: And he's going to be like that for a while. Anne: Yeah. Jay: But there's always going to be applications, and it could be for really short commercials. Anne: Yeah. Jay: It could be for no budget audio books where, you know what, I'm just going to throw the AI voice at it. And we're gonna certainly know it's fake, but it's not going to be like listening to Alexa reading audio. Anne: Right, right, exactly. Jay: Because it's going to, it's going to actually have some, have some level of dynamics. Anne: Well, I think as long as the listener, I mean, then it becomes like the consumer, right? And you know, as long as they're aware. You know, I don't have a problem listening to Alexa 'cause I know it's Alexa, and I don't feel like Alexa is trying to dupe me into thinking she's human. And so I feel that same way. If I'm aware, I don't have a problem in certain cases, listening to it as long as know. Jay: That's it. And that's also why we want to, if anything, empower creators to have control of their voice. And if they wanna use it for editorial corrections, fantastic. If they want to use it for some longer form projects that they don't actually have the time to do or the budget -- their clients might not have the budget to do it -- Anne: Right. Jay: That that's their choice. Anne: Wow. Well, this has just been so enlightening. Woo, thank you so much for talking to me and talking to our listeners and talking about this, this amazing product that just seems to keep going. You guys keep coming up with these really wonderful things. So congratulations on that. Where do you see AI going in five years or even ten years? Jay: I'm super excited about this. Like media production is now actually entering a phase where if you can dream it, it can happen. And we don't necessarily need the expensive studio or the years and years and years of audio or video production training. We just need our laptops. So you and I both seen this in our careers with, with the move, from editing on tape -- Anne: Yup. Jay: -- to digital and then with PCs becoming so powerful with tools like iMovie and Garage Band that, you know, truly anybody can be a creator, and professionals can work from home. Well, the thing is there were a lot of advances during this time on other parts of the production process, like filming on smart phones and being able to broadcast and publish on social media, YouTube and podcast hosts, but all that stuff in between, all the editorial, all the correcting out mistakes -- Anne: Yeah. Jay: -- uh, generating small replacements, re-records, cutting, all that has been painstakingly difficult. Anne: Yeah. Jay: So this is where AI is really stepping in. And this next wave is, is huge because everybody is going to have access to these tools that make life even simpler, and the next generation of storytellers have never had it so good. Anne: Yeah. Well, that's fantastic. Oh, my goodness. Thank you so, so very much again, for spending time with us today. I'm going to give a big shout-out to our sponsor, ipDTL. You too can connect like a BOSS and find out more at ipdtl.com. You guys, BOSSes, have an amazing week, and we will see you next week. Thanks again. Bye-bye. Jay: Bye, everybody. >> Join us next week for another edition of VO BOSS with your host Anne Ganguzza. And take your business to the next level. Sign up for our mailing list at voboss.com and receive exclusive content, industry revolutionizing tips and strategies, and new ways to rock your business like a BOSS. Redistribution with permission. Coast to Coast connectivity via ipDTL.

The Digiday Podcast
HuffPost's Danielle Belton sees the editor-in-chief role as being ‘newsroom therapist'

The Digiday Podcast

Play Episode Listen Later Oct 5, 2021 40:52


When Danielle Belton started as HuffPost's editor-in-chief in April, she stepped into a newsroom that had spent a year in tumult. In addition to the trials of covering and living through the pandemic, the news outlet's staff had gone through a sale from Verizon Media to BuzzFeed that eventually led to 70 HuffPost employees being laid off. And all the while, the newsroom had been without a leader. “They went so long without an editor-in-chief. The fact that there was going to be one put into place and that they were going to have their own leader independent of BuzzFeed and BuzzFeed News meant a lot. I felt like the reaction I got was actually more warm than anything else. And one of relief,” Belton said in the latest episode of the Digiday Podcast, which was recorded live during the Digiday Publishing Summit on Sept. 27 in Miami. Of course, Belton's appointment alone wouldn't instantaneously alleviate all stress and anxiety among HuffPost's staff. That's why the former editor-in-chief of G/O Media's The Root sees her role as being the outlet's “newsroom therapist.” It's a role she has found herself playing since she started working in journalism and spent time roaming newsrooms where she has worked to check in with other staffers. “I used to tell my bosses, ‘You guys should just pay me to be the newsroom therapist. I can just talk to everybody all day and listen to their problems and help them figure out how to solve them and help them with their stories. And that's basically what I'm doing now. I'm the newsroom therapist,” Belton said. This episode is the final in a four-part series for the Digiday Podcast called “The Modern Newsroom Leader,” featuring editors-in-chief as they navigate new industry challenges including staffers dealing with burnout, unsteady financial businesses and prioritizing diversity, equity and inclusion in hiring practices. Previous episodes featured The Cut's Lindsay Peoples Wagner and Vox's Swati Sharma, Houston Chronicle's Maria Reeve and Gawker's Leah Finnegan.

RENDERING UNCONSCIOUS PODCAST
RU166: DR MATTHEW FLISFEDER ON ALGORITHMIC DESIRE, SOCIAL MEDIA, PSYCHOANALYSIS, LACAN, MARX

RENDERING UNCONSCIOUS PODCAST

Play Episode Listen Later Oct 4, 2021 59:42


Rendering Unconscious welcomes Dr. Matthew Flisfeder to the podcast! Dr. Matthew Flisfeder is an Associate Professor of Rhetoric and Communications at The University of Winnipeg, where he teaches courses on Communication Theory, Popular Culture, Critical Theories of Discourse and Ideology, and Critical Studies of Social Media. He also teaches Cultural Theory in the MA program in Cultural Studies, and supervises Directed Readings and Special Studies courses on cultural/critical theory, media and communication theory, film and popular culture, social media, videogames, and cyberpunk culture. He is a Faculty Researcher affiliated with the Centre for Research in Cultural Studies (CRiCS) at The University of Winnipeg. He is an Editorial Board member for the journals Rethinking Marxism and TOPIA: Canadian Journal of Cultural Studies. https://matthewflisfeder.com His new book is Algorithmic Desire: Toward a New Structuralist Theory of Social Media (Northwestern UP 2021): https://matthewflisfeder.com/algorithmic-desire-toward-a-new-structuralist-theory-of-social-media/ Previous books include Postmodern Theory and Blade Runner (Bloomsbury 2017) and The Symbolic, The Sublime, and Slavoj Žižek's Theory of Film (Palgrave 2012). I am also the co-editor of Žižek and Media Studies: A Reader (Palgrave Macmillan 2014). https://matthewflisfeder.com Follow him at Twitter: https://twitter.com/MattFlisfeder This episode also available at YouTube: https://youtu.be/8O5Ie5uKBqQ Rendering Unconscious Podcast is hosted by psychoanalyst Dr. Vanessa Sinclair, who interviews psychoanalysts, psychologists, scholars, creative arts therapists, writers, poets, philosophers, artists & other intellectuals about their process, work, world events, the current state of mental health care, politics, culture, the arts & more. http://www.renderingunconscious.org Support the podcast at Patreon. Your support is greatly appreciated! https://www.patreon.com/vanessa23carl Rendering Unconscious Podcast can be found at your favorite podcasting platforms, including: Spotify / iTunes / Soundcloud / Podbean: http://www.renderingunconscious.org/about/ Dr. Sinclair is the author of The Pathways of the Heart (Trapart Books, 2021), Scansion in Psychoanalysis and Art: the Cut in Creation (Routledge, 2020) and Switching Mirrors (Trapart Books, 2016). Dr. Sinclair is the editor of Rendering Unconscious: Psychoanalytic Perspectives, Politics & Poetry (Trapart Books, 2019) Outsider Inpatient: Reflections on Art as Therapy (Trapart Books, 2021) with Dr. Elisabeth Punzi, On Psychoanalysis and Violence: Contemporary Lacanian Perspectives (Routledge, 2018) co-edited with Dr. Manya Steinkoler, and The Fenris Wolf, vol 9 (Trapart, 2017) co-edited with Carl Abrahamsson. http://www.drvanessasinclair.net Visit the main website for more information and links to everything: http://www.renderingunconscious.org Rendering Unconscious: Psychoanalytic Perspectives, Politics & Poetry (Trapart 2019): https://store.trapart.net/details/00000 The song at the end of the episode is “Seems like an eternity” from the album "Conceive ourselves" by Vanessa Sinclair and Pete Murphy from Highbrow Lowlife. https://vanessasinclairpetemurphy.bandcamp.com/album/this-is-voyeurism Many thanks to Carl Abrahamsson, who created the intro and outro music for Rendering Unconscious podcast. https://www.carlabrahamsson.com Image: Algorithmic Desire: Toward a New Structuralist Theory of Social Media (Northwestern University Press, 2021)

Build a Business Success Secrets
Making a Personal Connection with Patrick Stewart CEO of Apricot Lane | Ep. 172

Build a Business Success Secrets

Play Episode Listen Later Oct 4, 2021 77:36


Patrick Stewart is CEO of Apricot Lane Boutique – the most popular women's fashion franchise with over 80 locations. Apricot Lane Boutique first opened its doors in 2007 and in 2008 received the prestigious International Council of Shopping Centers Association (ICSC) as the Hot Retail Concept for Fashion – getting over 70000 votes in favor. Previous to Apricot Lane, Patrick was Chief Marketing Officer (CMO) of Sears Holdings where he was responsible for driving record revenue of $1.2B and a 35% increase in profitability. Before that Patrick worked as the Director of Brand Development at the J. Peterman Catalog (yes that one from Seinfeld) VP of Marketing and Creative at Big Dog Sportsware, VP of marketing at the Walking Company and EVP of Marketing at Crazy Shirts.  Patrick shares his story and lessons learned about marketing and branding along the way. Listen to this all things marketing conversation and you'll leave with plenty ideas to help your marketing and branding efforts with your business. Links from the show: Apricot Lane Boutique  

Contenders Wanted
Episode 27 - Equity versus Equality in parenting, business, and life with Prof. Brad Agle

Contenders Wanted

Play Episode Listen Later Oct 4, 2021 56:53


Show Notes:I think it's almost a universally understood fact of life that the old kids in a family are the guinea pigs and life tends to be very different when you compare the oldest and youngest children in a family. Part of that is that life circumstances change and part of that is that parents get better with time. Generally though, this is because parents tend to use an equity based parenting system and not an equality based system. But what is the difference between equity and equality and how can we use it to more effectively parent? On the show today we talk about this ethical principle and so many others that we can apply in parenting, business, and in life as we strive to make better decisions and have better long-term outcomes.Brad Agle is the George W. Romney Endowed Professor, and Professor of Ethics and Leadership in the Marriott School of Business at Brigham Young University (BYU). He is founder, chairman, and chief scientist at Merit Leadership and served as a Fellow and chair of the BYU Wheatley Institution Ethics Initiative from 2008 - 2020. Previous to his appointment at BYU in 2009, he spent 17 years as a professor of Strategy, Organizations, and Environment in the Katz Graduate School of Business at the University of Pittsburgh, where he also served for eight years as the inaugural director of the David Berg Center for Ethics and Leadership. His teaching brought the University of Pittsburgh the distinction of being the #2 ranked executive MBA program in the world in business ethics by Business Week. Dr. Agle received a Ph.D. in Business Management from the University of Washington and a B.S. in Information Management from BYU. In 2014 he published the book “Research Companion to Behavioral Ethics in Organizations: Constructs and Measures.” In 2016 he published the book "The Business Ethics Field Guide." Brad and his wife Kristi are the parents of Erik, Lindsay, Christian, and Amanda. On the show today we discuss the following:Who is Prof. Agle and what does he do (4:18)The creation of the ethical field guide for the special forces (5:30)The 13 Ethical Dilemmas (19:53)The ethics of loyalty and it's application in Nazi Germany (22:22)How to apply these principles outside your professional life (31:30)Consequences for not following ethical principles (37:03)Equity versus equality in parenting (41:22)What does it mean to him to be a Contender (45:27)How to learn more about Professor Brad Agle:Prof. Agle's full BYU BioProf. Agle's Book: The Business Ethics Field GuideAdditional Books, Individuals, or Items Discuss in the show:Moral InjuryDalow Concentration CampLeading SaintsThe Man in the Arena SpeechMerit LeadershipContact the Host: rob@contenderswanted.comGiveaway: If you'd like to learn what you need to do to be successful in your own life, we're giving away our free e-workbook called “How to Find Your Path to Your Success”. If you'd like a copy, click the link or email me at rob@contenderswanted.com with "Success" in the subject line.

Daily Insights by Rabbi Eli Silberstein
The 3 combinations of the 3 letters of the word צהר - maamar of previous rebbe

Daily Insights by Rabbi Eli Silberstein

Play Episode Listen Later Oct 4, 2021 4:12


The 3 combinations of the 3 letters of the word צהר - maamar of previous rebbe

Genuine Chit-Chat
#139 Pt 2 – Ria's Weird & Wonderful Questions: Favourite Ice, Bubble Tea & Being The God Of Something With Ria Carrogan

Genuine Chit-Chat

Play Episode Listen Later Oct 3, 2021 62:19


Ria Carrogan: the passionate podcasting extraordinaire is the guest this week and the 2-part conversation bounces between a huge range of topics including coping with depression, random questions (including favourite types of ice), mindset and so much more – a conversation covering couple of darker topics, intertwined with humour & somewhat cheery optimism! This week is part 2 and their conversation goes into “givers & takers” in relationships, a preview of Ria's upcoming Femme On Film show, before delving into some of Ria's questions from her website including favourite ice, what they would each be the God of and more! Ria also brings up her love of bubble tea, and they then discuss penises & sex scenes in film and the conversation finishes with a brief mention of reddit, buying CDs and Jeff Goldblum appreciation – a great end to a wild conversation! Ria's Twitter: @RiaCarrogan – https://Riasquestions.com - Shows she's found on in Comics In Motion are Seasons Greetings, Indie Comics Spotlight & Pop Guerrillas, plus Femme On Film is coming soon, all are found here: https://anchor.fm/comics-in-motion-podcast Last week, in part 1, their conversation started with how Ria first listened to podcasts, before talking about if Ria & Mike would rather lose their sight or hearing and the weird & wonderful websites that Ria's husband has made including Ria's Questions. Ria then opens up about her post-natal depression and how therapy helped her, before they delve into communication, mental post-it notes and positive nerdy online communities & civil discussion. Last episode, in number 139, the powerhouse of Star Wars couples makes their way onto our feed; Alex & Mollie Damon of Star Wars Explained! Their conversation includes what Star Wars means to Alex & Molly, their favourite SW facts and interactions with celebrities & fans at conventions, book recommendations for new Star Wars readers, some of their favourite Star Wars collectibles/paraphernalia, Mollie's cosplay, their thoughts on “extended” Star Wars movie and more – all perfect for any fans of Star Wars! Intro & Outro reads by BZ The Voice: http://www.bzthevoice.com/ Mike appeared on Star Wars Timeline's Timecast, talking about the different SW trilogies, found here: https://youtu.be/W03gonK4rtw Mike along with 5 other members of Comics In Motion discussed Art Spiegelman's Maus in the 2nd CiM Book Club: https://bit.ly/BC2Maus Mike appeared on the Have Not Seen This podcast, talking about The Way Way Back: https://spoti.fi/3AbPcV4 Mike & Tony Farina continue their Mark Russell journey by discussing his run of Flintstones comics on Indie Comics Spotlight: https://spoti.fi/3idkXqr Find Mike's other show; Star Wars: Comics In Canon on Spotify & the other podcast apps on the feed of Comics In Motion. Episodes are out every Saturday; episodes 0-72 are out now, in ep 72 Mike tackles the third full chapter of theWar Of The Bounty Hunters crossover event, in ep 71 Mike dives into the second volume of 2020 Aphra comics (that leads into War Of The Bounty Hunters) and in ep 70 Mike talks about Vader meeting Ackbar & the war against Mon Cala! Previous episodes topics include Lando comics, the Journals of Old Ben Kenobi, Kanan Jarrus, Count Dooku, Kylo Ren, Darth Maul, how C-3PO got his red arm, book reviews & more – https://spoti.fi/3sOtqCw Check out Mike's Patreon, where he releases 1 or 2 episodes of his “Afterthoughts” a week, plus there are unsplit full-length episodes of GCC, additional photos (including early access to photos of comics for this very show) and more, so if you want to support the show and get more content, check it out at http://patreon.com/genuinechitchat Instagram – Twitter – Facebook – YouTube – Stitcher – Podbean – Spotify You can also email Mike at GenuineChitChat@outlook.com with any reviews, comments or suggestions.

Mindfulness For Beginners
The power to heal yourself: let go of past pain

Mindfulness For Beginners

Play Episode Listen Later Oct 2, 2021 26:02


Why on earth would you want to rake up the past? Our experiences from the past influences the choices we make in the present - those choices can cause us suffering. To heal and let go of pain, we'll need to turn over the rock... Previous episode: https://podcasts.apple.com/gb/podcast/unravelling-your-head-spaghetti-guided-mindfulness/id1493806566?i=1000527669619 Join me at the Manchester Mindfulness Festival: https://www.eventbrite.co.uk/e/the-manchester-mindfulness-festival-tickets-162550092703 Email: mindfulnessforbeginners@protonmail.com Join the Facebook group: https://www.facebook.com/groups/999461463825856/ Say hello on twitter: https://twitter.com/mindfulness_for Plum Village app: https://plumvillage.app/ Meditation can be used to reduce stress / anxiety, improve your mood and live a more peaceful, fulfilled life. If you find it helpful, I invite you to share on Facebook and say hello! If you're on itunes / Apple Podcasts, you may wish to leave a review. May you be happy, may you be peaceful, may you be healthy and live a long life.

Trail Runner Nation
EP 540: Can You Be Fit and Still Be Unhealthy? Dr. Phil Maffetone Weighs In

Trail Runner Nation

Play Episode Listen Later Oct 1, 2021 67:24


Trail Runner Nation friend and frequent guest, Dr. Phil Maffetone, helps us understand that health isn't a simple byproduct of fitness; that fitness can be improved with better health.  He explains how we can become healthier and more fit athletes.  We refer to an article, "Athletes: Fit but Unhealthy". Other references: Get the Maffetone App HERE Take the 2 Week Test Get a taste of Dr. Maffetone's best articles HERE Keep listening past the credits for a song from Phil's most recent album, Outlier. Learn more about Phil Maffetone's MUSIC We had a fun Bonus Miles discussion with Phil that you can access as a Patreon Ambassador level or higher. Support the podcast by supporting these great partners: Athletic Green's AG-1 XO Skin's 'Socktober' sale.  Use code 'TRN15' for discounts on non-sale items Native Deodorant and use the code 'Trail' for 20% off your first order Other deals here Previous episodes with Dr. Maffetone: Get Stronger with Dr. Phil Maffetone Why is Weight-Loss so Difficult Even for Runners? Dr. Phil Maffetone Daydreaming is Healthy for Runners Dr. Phil Maffetone Unplugged Dr. Phil Maffetone was RIGHT all along! Take Your Shirt Off and Get Some Vitamin D - with Dr. Phil Maffetone Phil Maffetone: How can Rhythm Improve Your Efficiency? Breaking the 1:59 marathon with Dr. Phil Maffetone Dr. Phil Maffetone - Building a Better Athletic Brain Phil Maffetone transcribed! Eat to Win with Dr. Phil Maffetone. Dr. Phil Maffetone - Speed up by slowing down  

SportsBeat KC
Why this slow start is unlike the previous one for the Chiefs

SportsBeat KC

Play Episode Listen Later Oct 1, 2021 32:34


Not to worry. This sluggish start for the Chiefs is nothing like the last one, six years ago. That season, the Chiefs started 1-5 before finding their rhythm all the way to their first playoff victory in more than two decades. This team is better than that one was and gets a chance to prove it on Sunday in Philadelphia. The Star's coverage team of Vahe Gregorian, Sam Mellinger, Sam McDowell and Herbie Teope tackles the issues facing the Chiefs, and also why Josh Gordon was a good signing as well as Andy Reid's health scare from last weekend. Today's SportsBeat KC podcast show started as a SportsBeat Live stream and is now presented in audio form. Story links: Tyrann Mathieu identifies Chiefs' defense biggest issue. At least it's correctable Here's how Chiefs can avoid third straight loss Chiefs scheme: This recent trend has been killing the Chiefs and it's un-Andy Reid-like Chiefs-Eagles prediction: What will it take to end losing streak? Learn more about your ad choices. Visit megaphone.fm/adchoices

Fight For Brilliance with Justin Keller
One question that will help you take more action toward goals and ideas

Fight For Brilliance with Justin Keller

Play Episode Listen Later Oct 1, 2021 17:21


We're going to be in trouble if we are always waiting until we feel motivated, or the time is right, to take action toward our goals and ideas. In this episode, I talk about one question that I was taught to ask to help me take immediate action toward any goal or idea. This one question is so simple, yet it packs the power to move you closer toward what it is that you want to pursue.Previous episode on motivation: https://fight-for-brilliance-with-justin-keller.simplecast.com/episodes/understanding-and-improving-motivationJoin the Idea to Impact Mentorship Waitlist: www.yourideamentor.com Connect with Justin: instagram.com/kellerthinks | medium.com/@kellerthinks | Circlefifty.com | twitter.com/kellerthinks | TikTok.com/@kellerthinks | fb.com/kellerthinks | text "BRILLIANT" to 33777 to sign up for the Fight For Brilliance email 

Mornings with Jeff & Rebecca
Daily Dilemma: How Do I Motivate Myself To Do Hard Things?

Mornings with Jeff & Rebecca

Play Episode Listen Later Oct 1, 2021 4:47


Dear Doug & Rebecca,I broke my shoulder six weeks ago and have started physiotherapy. I have to do several exercises, several times a day, or I'll permanently lose my shoulder mobility. The problem is that they are really painful!How can I motivate myself to do something I just don't want to do? Previous experience tells me willpower isn't enough.

InForum Minute
Morning headlines: Number of COVID-19 deaths in North Dakota double in September from previous month

InForum Minute

Play Episode Listen Later Oct 1, 2021 2:37


Today is Friday, Oct. 1. Here are your top headlines from around the Fargo, North Dakota area.  InForum Minute is a product of Forum Communications, brought to you by reporters at the Forum of Fargo-Moorhead and WDAY TV. For more news from throughout the day, go to InForum.com.

Guru Viking Podcast
Ep115: Jhana, Ego, & Orgasm - Leigh Brasington, Shinzen Young, Chelsey Fasano, & Dr Sanguinetti

Guru Viking Podcast

Play Episode Listen Later Oct 1, 2021 105:30


In this episode special guest Leigh Brasington, Buddhist meditation teacher and author of ‘Right Concentration, A Practical Guide to the Jhanas', joins the ongoing conversation featuring: 

- Shinzen Young, meditation teacher and neuroscience research consultant
 - Chelsey Fasano, a Columbia University neuroscience student
 - Dr Jay Sanguinetti, Assistant Director for the Center for Consciousness Studies and Research Professor at the University of New Mexico In this episode Shinzen and Leigh engage in a detailed discussion about the variety of classifications of jhana in Buddhist scripture and the competing interpretations of them that exist today. They examine the contents and political context of 5th century text the Visuddhimagga and its author Buddhagosa and consider possible conflicts between its jhana system and the those of the Sutta and Abhidhamma literature. Chelsey reveals fascinating research on the neuroscience of pleasure and its relationship to meditational bliss, Jay shares the research on cognitive bias and religious belief, and the group ask the question if jhana and kriya phenomena are actually forms of epileptic seizure. … Video version available at: https://www.guruviking.com/ep115-jhana-ego-orgasm-leigh-brasington-shinzen-young-chelsey-fasano-dr-sanguinetti/ 
Also available on Youtube, iTunes, & Spotify – search ‘Guru Viking Podcast'.
 … Topics Include: 00:00 - Intro 01:45 - Sutta vs Visuddhimagga jhanas 06:53 - Complete absorption and nimitta 09:35 - Do jhanas confer an evolutionary advantage? 11:54 - Orgasmic jhanas 14:18 - Shinzen and Leigh discuss jhanas and lineage 25:40 - How enlightened was Buddhagosa? 29:55 -Sutta vs Abhidhamma vs Visuddhimagga 33:01 - Why did the Visuddhimagga become so popular? 37:14 - Leigh's orientation vs Shinzen's orientation 43:36 - The spiritual ego 47:11 - Cognitive bias and defense mechanisms in spiritual practice 54:38 - Sutta Nipāta on dogmatism and bias 59:05 - Is grasping fundamental to the brain? 01:01:54 - Leigh's enlightenment test 01:07:34 - The nature of pleasure 01:14:28 - Reducing inhibition to reveal states of bliss 01:15:33 - Centre-surround neurons 01:22:25 - Sensory processing according to Buddhism 01:27:24 - The neuroscience of pleasure 01:32:43 - Jhana and kriya as kinds of epileptic seizure 01:42:58 - Leigh's upcoming book on dependent origination … Previous episodes in this series: - https://www.youtube.com/playlist?list=PLlkzlKFgdknxjhwG5wmXRVfrkeGczVPVI To find out more about Leigh, visit, - https://www.guruviking.com/ep18-leigh-brasington-guru-viking-interviews/ - http://www.leighb.com/ - Case Study of Ecstatic Meditation: fMRI and EEG Evidence of Self-Stimulating a Reward System - https://www.hindawi.com/journals/np/2013/653572/ - How Many Jhanas Are There? http://www.leighb.com/howmanyjhanas.htm To find out more about Shinzen, visit: - https://www.guruviking.com/ep37-shinzen-young-pandemic-edition-guru-viking-podcast/ - www.shinzen.org To find out more about Chelsey, visit: - www.chelseyfasano.com To find our more about Dr Sanguinetti, visit: - https://www.guruviking.com/ep102-dr-jay-sanguinetti-cults-science-the-dalai-lama/ - https://www.jaysanguinetti.com/ For more interviews, videos, and more visit: - www.guruviking.com Music ‘Deva Dasi' by Steve James

Daily Insights by Rabbi Eli Silberstein
Beautiful story with Reb Levi Yitzchok of Barditchev- told by the Previous Rebbe on Lag Baomer 5699

Daily Insights by Rabbi Eli Silberstein

Play Episode Listen Later Oct 1, 2021 8:00


Beautiful story with Reb Levi Yitzchok of Barditchev- told by the Previous Rebbe on Lag Baomer 5699. Tonight is the yartzeit of Reb Levi Yitzchok

Outbound Metrics | B2B Outbound Sales
#130: (Re-Air) Building an Inbound Engine Using Outbound: 25% cold email reply rate + Webinars + LinkedIn + YouTube + Podcasts = $2M opportunity value (Ayhan Isaacs)

Outbound Metrics | B2B Outbound Sales

Play Episode Listen Later Sep 30, 2021 46:45


Well, what do you do when cold email doesn't work? You find the right prospects and use the right messaging but the sales meetings just don't come. That's exactly what happened to my guest. Ayhan Isaacs is the Founder of Growth Rhino. A sales agency that works with SaaS companies to build scalable outbound engines. He got into a situation where he was working with a client to drive sales meetings using cold email but his campaigns weren't working. He even tried Google Ads, Facebook Ads, and pretty much every other marketing channel to drive revenue but alas - nothing materialized form his efforts for six months. At this point - most people would give up and chalk it up to a loss. But, Ayhan didn't let this stop him. As a naturally curious and talented growth hacker Ayhan took a new approach to cold outreach that opened up a flood of new business for his client. But, the results didn't come like he expected. This new angle unlocked a revenue engine for his client's business and the results have continued to compound. Over the past 12 months he has taken the agency from 0 to 25K in MRR completely bootstrapped. Previous to running the agency Ayhan worked as a BDR at a number of couple different early stage startups followed by doing a number of consulting jobs. He is certified in Conversion Optimization from CXL institute and holds a Masters in Innovation & Entrepreneurship from Ryerson University. In this episode we'll take a look at the exact steps Ayhan took to connect with executives at Deutsche Bank, HSBC, KPMG, Orange Theory Fitness and other billion dollar companies. We'll discuss his outreach copy, how he leveraged Webinars, LinkedIn, and YouTube to build a content machine to drive new business 24/7, and how he iterated on his process to drive even faster results using fewer resources. Are you looking to build a multi-channel campaign that drives exponential growth? If so, make sure you listen to the very end of this episode. I'll see you on the other side. Join the Facebook Group (B2B SaaS Cold Outreach Mastery): https://morgandwilliams.com/fbgroup --- Send in a voice message: https://anchor.fm/morgan-williams0/message

Nialler9
Our favourite music of September

Nialler9

Play Episode Listen Later Sep 30, 2021 65:29


Our end of the month episode is all about the albums and songs we loved in the month of September. Niall and Andrea go one for one with albums from Little Simz, Andy Shauf, Cadence Weapon and Houseplants. Plus songs from HAAi, M(h)aol, Súil Amháin, Spider, Snail Mail, Kynsy and more. Plus TV, books and films we enjoyed. Listen to the episode below or Subscribe in your favourite podcast app: Subscribe in Apple | Android | ACAST | Pocketcasts | CastBox | Stitcher | Spotify | RSS Feed Songs played on the Nialler9 Podcast Spotify Playlist Andrea has a new podcast - My Favourite Album Support Nialler9 on Patreon and join our Discord chat + member playlists and content. Andrea has a Ghost newsletter Subscribe to the podcast and please leave a review on iTunes, tell your friends or commit to supporting us directly. Support us on Patreon. Previous podcast episodes

I Hear of Sherlock Everywhere

“I'll show you a grim little bit of evidence” [RETI]  Paul Churchill, BSI (“Corot”) delighted in recreating evidence boxes for each Sherlock Holmes story. After his death in 2008, Deborah Clark became their steward. Regular attendees of Watson's Tin Box see evidence boxes at every monthly meeting, but we wanted to give you a peek inside as well. Debbie sat down with us to detail what these evidence boxes are, how Paul created them, and what makes them so special.  The contents inside them (and outside of some of them) are astounding in their reality and detail, bringing the Sherlock Holmes stories to life in a unique way. We have posted . And of course, we have another Canonical Couplet to challenge your acuity. If you are chosen as a winner, you'll get The Sherlock Holmes Scrapbook by Peter Haining. Answers are due by October 14, 2021 at 11:59 a.m. EDT. Information on sponsors, links, and notes are available below.   Please do consider becoming a . Your support helps us to ensure we can keep doing what we do, covering file hosting costs, production, and transcription services.    Sponsors  has a new edition in the McCabe-Cody series: , available on September 28.    is the premier publisher of books about Sherlock Holmes and Arthur Conan Doyle, including Terence Faherty's .    has a number of new Kickstarters that need your attention: , , and .     Would you care to advertise with us? You can find . Let's chat!   Links This episode:  Previous episodes mentioned: Many more links, articles and images are available in our Flipboard magazine at  as well as through our accounts on , , , and .   And would you consider leaving us a rating and review? It would help other Sherlockians to find us.   Your thoughts on the show? Leave a comment below, send us an email (comment AT ihearofsherlock DOT com), call us at (774) 221-READ (7323).   Transcript We are so grateful for your support , which makes our transcripts possible. Every amount helps. A transcript will be available at .   --    

Tips For Guitar Playing Success
How to Play the D Scale on Your Guitar

Tips For Guitar Playing Success

Play Episode Listen Later Sep 30, 2021 9:13


Scales are a great way to learn the notes on your guitar, gain fretboard knowledge and it can help with finger agility and dexterity. Previous scale episodes have included the C & G scales, here's the D scale.  In this episode Marlene discusses the D scale notes, locations & how to play those notes on your guitar. For the D scale tab go to: Thursday Tips blog For virtual learning and more go to www.marlenesmusic.com Join the Club! Join today & receive exclusive member-only rewards! Featured on.. Podbean's Featured Podcast of the Week Podbean.com Best Guitar Podcasts Player FM Top 25 Guitar Podcasts Feedspot.com WiMN's website (Women's International Music Network) Available on... Apple Podcasts, Google Podcast, Amazon Music Podcast, iHeartRadio, Spotify, Pandora, Stitcher, Castbox and more! This podcast was made possible in part by I Create Sound For help getting your best sound, go to www.icreatesound.com

Entertainment(x)
Michael Mills Part 2: ”When offered, take the left turn”

Entertainment(x)

Play Episode Listen Later Sep 30, 2021 43:33


Michael Mills (LI:@michaelmills)(IG:@michaelmillsnyc)(ddmproductionsnyc.com) is a New York City-based communications consultant and producer with more than 25 years of global experience in broadcast, public relations, communications/image consulting and theatrical producing. He designs and leads comprehensive, engaging and impactful individual, team and group communications workshops and trainings. Participants include corporate executives, spokespersons, celebrities, industry leaders, experts, authors, not-for-profits, physicians, researchers, government officials, NGOs, associations, trade organizations, and sales and marketing staff. Michael has held sessions for more than 12,000 individuals and groups throughout the U.S., Canada, Mexico, Europe, Africa, Australia and Asia. Michael's impressive client base has been built by word of mouth and referral. He is known for relevant, informational, enjoyable, efficient and results-oriented sessions designed to develop and/or enhance messages, introduce or reinforce techniques, practice effective communication strategies and help develop leaders. He has extensive health and medical, nutrition and lifestyle expertise. Michael is also a Drama Desk Award winning theatrical producer, Executive Producer and Director. Current productions include; Little Shop of Horrors Off Broadway, Concrete Jungle, Mary and Max, Spandex the Musical, Kleptocracy, Monopoly Life-sized. Previous productions include Be More Chill, Unexpected Joy, Come Out, Come Out and The Made-up Musical.

Sherlock Holmes: Trifles
Plotting Lovers

Sherlock Holmes: Trifles

Play Episode Listen Later Sep 29, 2021 24:43


 “it was her plot as much as mine” [ABBE]  From the realm of conjecture: what if the star-crossed lovers in "The Adventure of Abbey Grange" and "The Problem of Thor Bridge" weren't simply victims of circumstance? What if the damsels in distress weren't being unfairly persecuted?    That is, what if they plotted the demise of the hated member of their love triangle and were able to fool Sherlock Holmes? It's just a Trifle.   Have you left us a rating and review on Apple Podcasts yet? You don't need to own an Apple device, and every review helps more people find the show.    Links / Notes This episode: ihose.co/trifles248 Inspired by Bob Byrnes' work in Baker Street Essays, Vol 1 No. 1 and Vol II No. 1. Previous episodes mentioned:  Episode 245: How Do You Solve a Problem Like Maria? Episode 180: The Eternal Triangle Find us on Facebook, Twitter, Instagram and YouTube Email us at trifles @ ihearofsherlock.com Support us on Patreon   Sponsor The Baker Street Journal   Music credits Performers: Uncredited violinist, US Marine Chamber Orchestra Publisher Info.: Washington, DC: United States Marine Band Copyright: Creative Commons Attribution 3.0   --        

Locked On Lions - Daily Podcast On The Detroit Lions
Why the #Lions are in good shape for Sunday. History lesson on previous 0-4 starts for coaches. #Lions moving up in power rankings? SEPT 29. #FirstListen

Locked On Lions - Daily Podcast On The Detroit Lions

Play Episode Listen Later Sep 29, 2021 22:45


Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Kill Your Inner Loser Show
Master Masters His Life

The Kill Your Inner Loser Show

Play Episode Listen Later Sep 29, 2021 65:46


Master joins me again to talk about how much has changed in the last few months since we last saw him - including having sex with another 9 girls, finding a girlfriend, finally feeling happy, becoming a more confident and well-rounded human being, and going for his dream job working at Activision. This man is a beast.Previous episode with Master: https://www.youtube.com/watch?v=sWUXXIUuSyAHaving 3somes with Girls Your Girlfriend Meets on Tinder: https://theinnerwinnershow.com/89/Greg Doucette: https://www.youtube.com/channel/UCLqH-U2TXzj1h7lyYQZLNQQRead my epic 5-part Get Laid on Tinder series (it's free): https://killyourinnerloser.com/tinder-guide-sfw Want COACHING with me, legendary results and an elite dating/sex life? I offer group coaching, and more hardcore 1-on-1 coaching: https://killyourinnerloser.com/coaching-sfw 

Crit Academy: A Dungeons and Dragons Podcast
How to Run Hardcore Combat in Dungeons & Dragons with Grit & Glory

Crit Academy: A Dungeons and Dragons Podcast

Play Episode Listen Later Sep 29, 2021 60:27


Brace Yourself… From project lead Apostol Aostolov and a talented community of DMs we discuss Grit & Glory! For decades, running realistic campaigns using the world's greatest role-playing game has been an impossible feat. Previous editions showered players with supernatural abilities and magic items until only monsters of legend present a formidable challenge. In this episode, we discuss Grit and Glory, an Advanced Player's Guide to low fantasy and expanded combat, equipment, attrition, and recovery rules that focus on gritty gameplay.

Nourish Balance Thrive
Finding Social Connection in a Disconnected World

Nourish Balance Thrive

Play Episode Listen Later Sep 24, 2021 78:36


Ben Greenfield is a human performance consultant, speaker, and New York Times bestselling author of 13 books, including the popular titles “Beyond Training”, “Boundless” and “Fit Soul”. Former collegiate tennis, water polo, and volleyball player, bodybuilder, 13-time Ironman triathlete, and professional obstacle course racer, Ben has been voted by the NSCA as America's top Personal Trainer and by Greatist as one of the top 100 Most Influential People In Health And Fitness. In 2014, my NBT co-founder and medical doctor Jamie Kendall-Weed and I appeared on the Ben Greenfield podcast, and to this day people tell me that's how they learned about Nourish Balance Thrive.  ​For this podcast, Ben and I met up on the UCLA campus during the Ancestral Health Symposium in August to walk and talk about the harmful effects of loneliness and the importance of social connection. Ben shares some of the innovative ways he's increased connection with others, despite being a self-proclaimed introvert. We talk about some of the downsides of social isolation and the best reasons for opening yourself up to the “messiness” of others.  Here's the outline of this interview with Ben Greenfield: [00:01:48] Previous podcasts with Ben Greenfield featuring Christopher Kelly: Why Is My Cortisol High Even Though I'm Doing Everything Right? Hidden Causes Of High Cortisol, The DUTCH Test & More!, The Little-Known Test That Tells You Everything You Need To Know About Your Metabolism, and 7 Signs Your Cortisol And Adrenals Are Broken. [00:03:21] James Nestor; Podcast: How to Fix Your Breathing to Improve Your Health. [00:03:27] Diana Rodgers; Podcast: Kale vs Cow: The Case for Better Meat. [00:03:50] All the 2021 AHS videos are on YouTube. [00:06:52] Book: Loneliness: Human Nature and the Need for Social Connection, by John T. Cacioppo. [00:07:01] Book: Why Zebras Don't Get Ulcers: The Acclaimed Guide to Stress, Stress-Related Diseases, and Coping (Third Edition), by Robert M. Sapolsky. [00:09:56] Book: The Martian, by Andy Weir. [00:11:47] Introversion. [00:12:00] Book: The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous, by Joseph Henrich. [00:12:25] Recent podcast with Lucy Mailing, PhD: Rewilding the Gut: Restoring Ancestral Diversity to the Microbiome. [00:13:53] Book: Quiet: The Power of Introverts in a World That Can't Stop Talking, by Susan Cain [00:18:21] Loneliness is as bad for you as smoking; Study: ​​Dyal, Stephanie R., and Thomas W. Valente. "A systematic review of loneliness and smoking: small effects, big implications." Substance use & misuse 50.13 (2015): 1697-1716. [00:18:49] Loneliness vs. social isolation. [00:25:20] Book: Never Eat Alone, Expanded and Updated: And Other Secrets to Success, One Relationship at a Time, by Keith Ferrazzi. [00:26:39] Mastermind Talks, created by Jayson Gaignard. [00:27:34] Ben's dinner parties. [00:33:04] Julian Abel, MD; Book: The Compassion Project: A case for hope and humankindness from the town that beat loneliness; Julian's Podcast: Survival of the Kindest.  Listen to Julian's most recent interview on the NBT Podcast. [00:35:40] Opening yourself up to the messiness of other people. [00:38:38] Ben's article on the dopaminergic response while experiencing pain or pleasure with others. [00:39:40] Book: Friendship in the age of loneliness: An Optimist's Guide to Connection, by Adam Smiley Poswolsky. [00:40:40] Contacts+. [00:42:26] Community events; Realm Church Management Software. [00:48:23] Ben's expanded spiritual practice. [00:52:34] Books by Jamie Wheal: Stealing Fire and Recapture the Rapture. [00:53:13] Book: The Immortality Key: The Secret History of the Religion with No Name, by Brian C. Muraresku. [01:01:59] Church and the monogamous nuclear family. [01:11:05] Eye gazing. [01:14:44] See Ben's show notes for this recording. [01:15:52] Join the NBT Elite Performance Club Forum by supporting NBT on Patreon.