Podcasts about mucosal

Mucosal melanoma is a rare and aggressive form of melanoma that arises from the mucous membrane. In this podcast, we focus on mucosal melanoma of the head and neck. Led by A/Prof Sydney Ch'ng, our multidisciplinary experts discuss how it differs from cutaneous melanoma, staging of mucosal melanoma, management of the disease and future treatments. The discussion concludes with a case study to summarise key learnings. This podcast is suitable for Plastic Surgeons, Surgical Oncologists, Dermatologists, Medical Oncologists, Pathologists, GPs, Nurses and other healthcare professionals. SPEAKERS A/Prof Sydney Ch'ng - Plastic & Reconstructive Surgeon and Head & Neck Surgeon, Melanoma Institute Australia | Associate Professor of Surgery, The University of Sydney Prof Georgina Long AO - Co-Medical Director, Melanoma Institute Australia | Chair, Melanoma Medical Oncology and Translational Research, Melanoma Institute Australia and Royal North Shore Hospital, The University of Sydney A/Prof Raewyn Campbell - Rhinologist and Anterior Skull Base Surgeon |Associate Professor, Macquarie University Dr Robert Rawson - Pathologist, Melanoma Institute Australia and Royal Prince Alfred Hospital Prof Angela Hong - Radiation Oncologist, Melanoma Institute Australia | Clinical Professor, The University of Sydney Please note that this podcast was accurate at the time of recording (March 2024) but may not reflect the rapidly evolving treatment landscape and approvals in Australia. MIA's Education Program is proudly supported through unrestricted educational grants from MSD, BMS and HEINE.

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On this episode, we take recap on the HIDDEN stressors on the body, the Five Pillars of Health Succes (TM) and we provide a general overview of Leaky Gut and how mucosal barrier testing can help paint the picture of your body's health. Follow us on IG ⁠⁠⁠⁠⁠⁠@functionallyenlightened⁠⁠⁠⁠⁠⁠ to be notified when new interviews with amazing functional practitioners and chronic illness warriors are published or to hear more prayer points. Visit ⁠⁠www.functionallyenlightened.com⁠⁠ for information on how we work or to subscribe to our newsletter. --- Send in a voice message: https://podcasters.spotify.com/pod/show/functionallyenlightened/message

We often don't get the chance to hear from survivors and patient advocates whose lives have been impacted by advanced medicines; so that makes this podcast episode special as we talk to Chris White, a cancer survivor who faced the unimaginable when diagnosed with Mucosal Melanoma in 2018—a rare and aggressive cancer which makes Chris's journey even more exceptional. Today, Chris is not just a survivor; he's a beacon of inspiration. He has redirected his energy towards advocacy, prevention, and raising awareness of the complexities associated with Mucosal Melanoma. Tune in to listen to Chris's extraordinary odyssey, exploring the challenges he faced throughout his treatment journey and proving that with resilience, determination, and hope, anything is possible.

When Chris White noticed a bump on his rectum, he thought it was nothing more than a pimple.  Not only did the bump turn into a diagnosis of a rare type of skin cancer, but the cancer metastasized to his brain.  In addition, to get the treatment he needed, Chris faced barriers from his insurance carrier and the windows for the much-need clinical trial, but he overcame everything in his path.  He has resumed snowboarding and skateboarding and travels the country as an inspirational speaker.

Today we get an update on where the TB Vaccine pipeline is up to, how TB vaccines work and what exciting candidates might be on the horizon. We speak with Professor Jamie Triccas from the University of Sydney about his work as the principal investigator on the Advancing Vaccine Adjuvant Research for Tuberculosis (AVAR-T) which is an NIH funded project to identify the most promising adjuvant-TB immunogenicity candidates for development.REFERENCESStewart, Erica, James A. Triccas, and Nikolai Petrovsky. "Adjuvant strategies for more effective tuberculosis vaccine immunity." Microorganisms 7.8 (2019): 255.Counoupas, Claudio, James A. Triccas, and Warwick J. Britton. "Deciphering protective immunity against tuberculosis: implications for vaccine development." Expert Review of Vaccines 18.4 (2019): 353-364.Triccas, James A., and Jonathan K. Nambiar. "Challenge of developing new tuberculosis vaccines to generate life-long protective immunity." Expert Review of Vaccines 8.7 (2009): 823-825.Counoupas, Claudio, et al. "Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection against pulmonary tuberculosis." npj Vaccines 5.1 (2020): 105.Counoupas, Claudio, and James A. Triccas. "The generation of T‐cell memory to protect against tuberculosis." Immunology and Cell Biology 97.7 (2019): 656-663.Triccas, James A., and Claudio Counoupas. "Novel vaccination approaches to prevent tuberculosis in children." Pneumonia 8 (2016): 1-7.Counoupas, Claudio, et al. "Protective efficacy of recombinant BCG over-expressing protective, stage-specific antigens of Mycobacterium tuberculosis." Vaccine 36.19 (2018): 2619-2629.Counoupas, Claudio, et al. "Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice." npj Vaccines 1.1 (2016): 1-11.

Today I'm going to cover the best tests for low stomach acid and what to do for a deficiency in stomach acid. The best tests for a stomach acid deficiency: 1. Riddler's gastric acid reflux point test Press on your rib cage one inch below your breastbone and one inch to the left. If the area is tender, you may lack stomach acid. 2. The baking soda test Dissolve 1/4 tsp. of baking soda in eight ounces of water and drink it in the morning before eating. If you don't have enough acid in your stomach, you may start burping within one to five minutes. 3. The betaine hydrochloride test Take one betaine hydrochloride supplement before eating, and add more with each meal. If you have low stomach acid, your symptoms will be relieved. Symptoms of low stomach acid (low hydrochloric acid): • Indigestion • Gas • Bloating • Acid reflux • GERD Another common problem people experience as they age is called atrophic gastritis. Symptoms of atrophic gastritis: • Mucosal atrophy • Low hydrochloric acid • Low B12 or folate • Low iron • Intolerance of red meat • Indigestion • Gas • Cognitive decline • Brittle nails • Restless legs • Thinning hair • Acid reflux • Muscle cramps or muscle twitches • Rosacea • Bad breath Common causes of atrophic gastritis: 1. H. pylori What to do: • Consume sulforaphane 2. Low hydrochloric acid What to do: • Take betaine hydrochloride • Take methylcobalamin and methylfolate In some cases, you may need to fix the inflammation in your gut before you increase your stomach acid. You can do this by consuming cabbage juice, wheatgrass juice powder with water, zinc, and probiotics. It's also important to get on a Healthy Keto® diet.

This week we will discuss a rare type of cancer.  Our guest on today's show is Chris White.  Mucosal melanoma is a rare but aggressive disease usually diagnosed in advanced stages. Unlike most melanomas, which start in the skin, mucosal melanoma starts in the moist membranes that line the inside of the body, including the digestive tract. All melanomas start in pigmented cells called melanocytes. Mucosal melanoma accounts for 1.4 percent of all melanomas, according to a 2018 review in Melanoma Management. ​Most mucosal melanoma cases start in the lining of the head, neck, anus, vagina or vulva. Cases inside the gastrointestinal tract are less prevalent. The disease may be called invasive if it's spread deep into the tissue and metastatic if it's spread to distant parts of the body, such as the liver or lungs. ​​Mucosal melanoma hasn't been linked to any specific causes. Generally, older people are diagnosed, with the median age being 70. While the rate of skin melanoma cases has risen in the past 20 years, the rate of mucosal melanoma has always been fairly similar over time. ​ More About Our Guest Chris's story begins in Colorado Springs where he was born in 1982. His parents and two siblings moved to Irvine California where he grew up before moving to North Texas. He received his Associates of Arts degree at Collin College, followed by his BA at University Texas Dallas in 2005. After college, his career path included time in the in the oil and gas industry, working with independent SAP contract consultants as well as working in the Golf department at Gleneagles Country Club in Plano, Texas. His career path took a turn in 2016 when he worked in the home building industry as a construction manager. An avid snowboarder, he has always been active, enjoying outdoor activities. His cancer journey began in the summer of 2018 when what he had believed was a hemorrhoid actually turned out to be cancer. Not just any cancer, but the diagnosis was Anorectal Mucosal Melanoma which is an extremely aggressive cancer with a low survival rate.  The following months included multiple surgeries, immunotherapies, chemotherapy and radiation. Despite the treatments, the cancer had metastasized throughout his body to his lungs, liver, kidneys and brain. His health was declining rapidly, and without any other options, he was fortunate enough to qualify as the last patient admitted to a TILs Therapy Clinical Trial at the University of Colorado Health Cancer Care located at the Philip Anschutz Medical Campus in Aurora Colorado. The TILs therapy was done in January of 2020 and within less than a year the tumors were gone. Not in remission but gone. The TILS therapy is revolutionary in that it eradicates the tumor rather than leaving it dormant. This clinical trial for TILS therapy saved his life. He was able to go back to work in homebuilding but realized his passion is sharing his cancer survival story. Currently he works as a Certified Melanoma Educator through the Melanoma Research Foundation. He is involved with many melanoma patient advocacy groups throughout the world listening to other stories while sharing his own via group chats, industry panels and forums any format that can offer some patient the comfort that there may a cure for their cancer. Any contribution to the MRF aids the fight against Melanoma and Chris thanks you for your support and generosity. ​  

Did you know that immunoglobulin A nephropathy has very recently seen 2 treatments first licensed for its management? Credit available for this activity expires: 6/29/24 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/993766?ecd=bdc_podcast_libsyn_mscpedu

CME credits: 0.50 Valid until: 14-06-2024 Claim your CME credit at https://reachmd.com/programs/cme/strategies-for-achieving-mucosal-healing/15524/ This Medical Minute will discuss how to identify and target objective measures of ulcerative colitis disease activity to achieve mucosal healing. =

John MacKenzie chats with Associate Professor Severine Navarro, Team Head of Mucosal Immunology at QIMR Berghofer Medical Research Institute, about groundbreaking trials of a new treatment for asthma sufferers. The QIMR Berghofer Institute is appealing for donations to help fast-track clinical trials for a new anti-inflammatory protein that can now be synthesised. The protein is proving effective to treat asthma and could potentially work to treat a range of other conditions including hay fever, food allergies, and even coeliac. 

In this episode, we will explore a range of oral mucosal presentations including oral lichen planus, Sjogren's syndrome and presentations suggestive of malignancy. To guide us through this challenging topic, we are again joined by special guest experts, oral medicine specialist Dr. Simone Belobrov and dermatologist A/Prof Laura Scardamaglia. See omnystudio.com/listener for privacy information.

In this episode we will focus on a particularly common oral mucosal presentation, ulcers. We'll explore common causes of mouth ulcers, how are these diagnosed, how to investigate for underlying conditions, and how to manage them. To guide us through this challenging topic, we are joined by special guest experts, oral medicine specialist Dr Simone Belobrov and dermatologist A/Prof Laura Scardamaglia.  See omnystudio.com/listener for privacy information.

Dr. Bana Jabri is the Sarah and Harold Lincoln Thompson Professor in the Department of Medicine and the Research Director of the Celiac Disease Center at the University of Chicago. Her research focuses on innate and mucosal immunity, particularly in celiac disease, autoimmune disorders, and inflammatory bowel disease. She talks about the mechanisms of celiac disease and new treatment options. She also discusses how the microbiome can affect immune responses in cancer.

Join the Dr. Jen the vet, Dr. Jason Chatfield and Dr. Amy Stone on "Chats with the Chatfields" as they explore mucosal vaccines and their impact on both veterinary and human medicine. Gain valuable insights into the science behind these innovative immunization strategies, including their applications in protecting pets and humans alike. Discover the challenges and opportunities that lie ahead in this thought-provoking episode, which promises to inspire and educate listeners about the future of vaccine research and its significant global health implications. Don't miss out on this enlightening conversation and discover why you should be asking your vet about intranasal and oral vaccines for your pet!Dr. Amy StoneDr. Stone is a clinical assistant professor at the University of Florida's College of Veterinary Medicine (UFCVM). Since 2006, she has served as chief of the Primary Care and Dentistry Service at UFCVM's Small Animal Hospital. She serves on the AAHA/AAFP Feline Vaccination Task Force and is a contributing reviewer for the AAHA Canine Vaccination Guidelines. She received her DVM and PhD from the University of Florida. Her PhD focus was in pulmonary immunology, and her postdoctoral research involved work on a human periodontal disease vaccine.This episode is certified to provide 1 hr of PACCC CEU's!  The unique code will be delivered during the episode, so listen up! Don't know what PACCC is? And why would they be involved in CEU's?  Pet lovers can get more information at www.paccert.orgShow our sponsors some love:FullBucket Veterinary Strength Supplements - the leader in digestive health for horses, dogs, and cats!Merck Animal Health - the science of healthier animalsSUBSCRIBE to our show on Youtube or on our website: https://chatfieldshow.comFollow us on instagram @ChatfieldShowShare this episode with a friend who needs to hear it...or might be interested in the topic...or just to make their day brighter! :)

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Benoit Chassaing, group leader from the “Mucosal microbiota in chronic inflammatory diseases” Team at INSERM and the Université Paris Cité, Paris, France, on the paper 'Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism' published in paper copy in Gut in May 2023 and available online: https://gut.bmj.com/content/72/5/906 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Richard D. Carvajal, MD, discusses mucosal melanoma and treatment options for the disease.

Dr. Paul Alexander Liberty Hour – The alarm with findings such as these is when you extrapolate them to millions of Americans who took the COVID gene injection (mRNA) (and especially young persons, note alarming research is showing females are also impacted, e.g., myocardial lesions, with the mRNA shots) and the sequelae are ‘silent' and then as...

In this episode, we break down the initial approach to the evaluation of a patient with a suspected bleeding disorder, particularly in regards to hemophilia, including standardized bleeding assessment tools, the basics of the coagulation cascade, and mixing studies. The first step is taking a thorough bleeding history:The Fellow on Call Bleeding Assessment: 1. Mucosal bleeding working from nose down: epistaxis (did they need cauterization), gum bleeding, bleeding with tooth pulling, hematochezia, hematuria, menorrhagia or excessive post-partum bleeding2. Skin: Bruising, petechiae, telangiectasias 3. “Ortho bleeding”: spontaneous joint or muscle hematoma (raises concern for hemophilia) 4. Prior surgical or family history?5. Medications? Always clarify: are these issues lifelong?The International Society for Thrombosis and Hemostasis scoring tool is useful for standardizing bleeding symptoms, and it can help you determine the likelihood that a patient has an underlying bleeding disorder.Physical exam: Pay particular attention to: * Assess skin for bruising or petechiae* Assess the fingertips* If having epistaxis, may need to have help to assess nostrils for anatomical issues (vessels)* Assess mucosal surfaces for telangiectasias which could point to a diagnosis of Hereditary Hemorrhagic Telangiectasia, a mimicker of bleeding disorders* Assess thighs and flanks for obvious signs of bruising/bleedingWe sort bleeding disorders into two large buckets:* Platelet dysfunction → minor bleeding (i.e., mucosal bleeding, epistaxis) * Factor deficiency → major bleeding (i.e., joint effusions, spontaneous ICH) The basic workup includes: * CBC - to assess for low platelets * Peripheral smear - rule out schistocytes (DIC)* CMP - to check for liver dysfunction or severe renal dysfunction/uremia which leads to platelet dysfunction * PT/INR, aPTT, fibrinogen* Von Willebrand PanelCoagulation Cascade: * PT → measures the extrinsic pathway → factor 7 (lucky) * PTT → measures the intrinsic pathway → factors 12, 11, 9, 8 (TENET)* Intrinsic and extrinsic pathway feed into the common pathway → factors 10, 5, 2, 1 (All dollar bills less than $20) If a patient has an abnormal PT/PTT, you must ask: is it a lack of a necessary clotting factor or something interfering with the time it takes a clot to form? You assess this with a mixing study.* A mixing study combines equal parts of the patient's plasma with control plasma. * Mixing study corrects → deficiency of a coagulation factor * Mixing study does not correct → antibody interfering with assay or the function of the factors in the coagulation cascade **To correct, the time must be in the normal range for the assay, not just slightly improved!**The mixing study is assessed at time points 0 hr, 1 hr, 2 hr; the presence of an inhibitory may improve the time initially, but can then become longer again at time points 1hr and/or 2hrAfter the mixing study, then you also need to know which of the factors is the issue! How to do this: * Functional assays can be ordered to measure individual coagulation factor function.* Factor 11 – Hemophilia C* Factor 9 – Hemophilia B* Factor 8 – Hemophilia A * Understanding the coagulation cascade allows you know quickly know what to orderReferences:https://bleedingscore.certe.nl: ISTH/SCC Bleeding Assessment Toolhttps://ashpublications.org/ashclinicalnews/news/2436/How-I-Teach-the-Coagulation-Cascade: “How I Teach the Coagulation Cascade” by Dr. Alice Ma at University of North CarolinaLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin, L.R. Baden, and S. Morrissey. Audio Interview: Developing Mucosal Immunity to Covid-19. N Engl J Med 2022;387:e29.

Electric flight, Levitating nanoparticles, Asteroid smashing, Doppelganger genetics, Embryonic formation, Mucosal evolution, Meal worm meals, Burn-based timekeeping. Jennifer, Angie, and Way discuss the curated links for the week of 9/02/2022. Please consider supporting this ad-free content on Patreon.

This podcast highlights original research published in the July official journal of the American Academy of Otolaryngology—Head and Neck Surgery (AAO-HNS) Foundation. The objective was to determine the range of incidental mucosal changes in a general sinonasally asymptomatic population on radiology. In conclusion, the prevalence of incidental mucosal changes in a general asymptomatic population on radiology needs to be considered when making a diagnosis of chronic rhinosinusitis.   Click here to read the article.

"Learn about the fascinating field of mucosal immunology, vaccine effectiveness, and the role of face-mask protection not from virus particles but “spiticles and snoticles”. Dr Peter Openshaw, ESWI Board Member and Professor of Experimental Medicine, Imperial College London, expertly guides us through what led to the unprecedented speed of COVID-19 vaccine development. From his experience of two pandemics, he offers a vision of future variants and how SARS-COV-2 is continuing to evolve.”This podcast is kindly sponsored by Viatris. 

In this week's episode, we'll discuss the efficacy of canakinumab in children and young adults with sickle cell anemia, learn more about the use of donor-derived multiple leukemia antigen specific T-cell therapy to prevent relapse in post-transplant patients with ALL, and discuss the defects in nasopharyngeal mucosal immunity in patients with severe combined immunodeficiency after hematopoietic stem cell transplantation.

Vitamin D sure gets a lot of airtime, but Vitamin A is equally as important to immune health and beyond. Here's some new details about this important fatty nutrient should know about. Save on essential micronutrients like Vitamins D and A in their most bioavailable forms at MYOXCIENCE: Use code podcast at checkout to save Links to video and images: https://bit.ly/vitamin-a-treg Time Stamps: 00:18 Vitamin is as much or more protective than vitamin D. 01:15 The 3 forms of vitamin A are retinol, retinoic acid and retinal. Retinoic acid is the most bioactive form. Cod liver, liver and carrots are rich in vitamin A. 02:22 Vitamin A helps to induce immune tolerance. Autoimmune diseases are characterized by a loss of tolerance. The immune system overreacts to tissues that it shouldn't. 03:44 You may benefit from increasing intake of vitamin A if you have allergies, skin issues or systemic autoimmune disease. Chronic use of vitamin A, 5,000 to 10,000 IU, may be beneficial. 04:05 If you believe that you have contracted an illness or pathogen, you can do short term supraphysiologic levels of retinoic acid or retinol. For non-pregnant adults, this is between 100,000 and 200,000 IU for several days. 05:20 Retinoic acid increases activity of T regulatory cells. 05:57 T regulatory cells help to pull back unrestrained inflammation and aggression toward cell tissues. Overweight and obese people have lower amounts of T regulatory cells. Leptin, from fat tissue, suppresses functional activity of T regulatory cells. 06:33 If you have a metabolic disorder, like obesity or insulin resistance, you can manifest immunologic disease like allergies, cancer, and susceptibility to severe infection. You can exercise, do some fasting, eat real food and try vitamin D and vitamin A supplementation from diet or supplements. 08:20 Mucosal immunity is immunoglobulin antibodies from T cells in the mucus membranes of your nose, lungs, saliva, and GI tract. Vitamin A helps to prime these immune cells as part of the mucosal memory.  Your mucosa is part of your front-line defense, and they are highly influenced by vitamin A and vitamin D. 09:45 The retinoic acid receptor is very close to the vitamin D receptor, and they share signaling pathways.    

One of our most common consults in hematology is teams seeking guidance for workup and management of thrombocytopenia. In this episode, we cover our approach to this hematologic conundrum. Major Points Covered:Thrombocytopenia is defined as a platelet count

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3 January 2021 - “Mucosal immunity is likely the best strategy to go forward fighting this pandemic. It's like placing the guard outside the door instead of inside the door,” immunologist Akiko Iwasaki told the EMBO podcast. Iwasaki has been studying how the immune system fights infections at the interfaces between the host and the environment ever since graduate school when she challenged the prevailing dogma about how DNA vaccines work. Her lab has made fundamental contributions to our understanding of the pathophysiology of COVID-19, using patient samples and data, as well as developing new model systems. We discussed her research, some of the challenges of science communication during the pandemic, and her approach to teaching. Akiko Iwasaki was elected an EMBO Associate Member in 2021.

Dr. De'Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania. The Herbert lab is exploring the immunoregulatory and regenerative mechanisms operating at the mucosal interface. He discusses his recent paper on IL-33 sources and secretion, his postdoctoral fellowship in South Africa, and the M1/M2 macrophage paradigm.

We often think of “leaky gut” when we hear the words “mucosal integrity”, but, as you'll learn in today's episode, the mucosal integrity is much more complex. Join me and Dr. Tom Fabian to discuss the intricacies of the mucosal barrier from a structural and physiological perspective. Think of this as your Leaky Gut 2.0 […] The post #279: Mapping Mucosal integrity with Dr. Tom Fabian appeared first on Functional Nutrition Alliance.

This episode we speak with Dr. Jasmine F. Millman at Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Graduate School of Medicine, University of the Ryukyus, Okinawa. She, with co-authors, Shiki Okamoto, Taiki Teruya, Tsugumi Uema, Shinya Ikematsu, Michio Shimabukuro, and Hiroaki Masuzaki published a review examining findings from recent studies regarding the impact of EVOO on gut microbiota and intestinal health and explore how modulations in composition of gut microbiota, production of microbially produced products, and activity and functioning of the mucosal immune system may lead to favorable outcomes in cardiovascular, metabolic, and cognitive health. I look forward to having you listen in to our discussion.

Dr. Sarah Rahal is a double board-certified pediatric neurologist, board certified headache specialist, also trained in functional medicine and environmental health. She trained at Columbia Presbyterian Hospital in New York and previously was Assistant Professor of Neurology and Pediatrics at Icahn School of Medicine at Mount Sinai Hospital in NY where she ran the pediatric headache program, and also sat on the board of the National Headache Foundation.Currently, she is the founder and CEO of ARMRA - a consumer health company that harnesses the power of bioactives from the natural superfood colostrum to develop solutions that address the modern root causes that threaten health.Dr. Rahal shares the fascinating link between our mucosal barriers and all modern chronic disease, and why this may be the key to keeping our gut and immune systems healthy. Colostrum, aka "Liquid Gold", has incredible healing properties for not only newborns, but adults as well. She provides recommendations on consuming and supplementing this key nutrient to help us through our current health epidemic.SHOW NOTES::51 Welcome to the show!3:08 The root cause of gut dysfunction3:36 Dr. Sarah Rahal's bio4:28 Welcome her to the show5:01 What is the root of our health epidemic?8:06 Her research on Colostrum11:45 The mucosal barrier explained14:22 Research on links between mucosal barrier and all modern chronic disease16:05 Symptoms related to barrier dysfunction 17:33 Damage to specific parts of the body20:40 Ecosystem of immune cells22:32 Colostrums effect on LPS24:00 Newborns and colostrum in breast milk24:37 Specific benefits of colostrum27:19 *LightPath LED Ad*30:32 Prebiotics & SIBO31:39 The issue with probiotics33:10 Supplementation with high SigA levels36:08 Is dairy really bad for us?40:44 Lauren's raw milk experience42:39 How long does it take to see changes?45:10 Colostrum for muscle building & fat burning46:20 Did our ancestors consume it?47:01 All about ARMRA49:50 When to take colostrum51:52 Her final piece of advice52:35 Thanks for tuning in!RESOURCES:Website - ARMRA - Save 20% with code BIOHACKERBABES20IG - ARMRAIG - Dr RahalLightPath LED - Save 5% with code BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donations

What is mucosal immunity? Thanks for asking! It was announced last week that Covid booster vaccines would soon be available to millions of people across the UK, including all over 50s and other people with underlying health conditions. In the meantime, new ways to combat the virus are emerging, specifically that of an nasal spray vaccine designed to boost mucosal immunity. Regular listeners may recall our recent episode on this kind of vaccine. The latest developments this month saw a team of French researchers present promising results from preliminary clinical trials on mice and hamsters.How is mucosal immunity different to what's generated by traditional vaccines then? Are you saying we won't ever reach herd immunity with the existing vaccines? In under 3 minutes, we answer your questions!To listen to the last episodes, you can click here:What are Butler Cafés?What is last chance tourism?What is toxic positivity?A podcast written and realised by Joseph Chance. See acast.com/privacy for privacy and opt-out information.

Paper discussed in today's episode: E-Cigarette Use Alters Nasal Mucosal Immune Response to Live-attenuated Influenza Virus 

Microbiologist Kiran Krishnan "Tending to your mucosa is one of the most important health steps you can take to improve your chance of wellness. And so the Gut 4-tify is designed to be that critical tool to help you tend to your mucosa.”

• Take Dr. Berg's Free Keto Mini-Course! • How to Bulletproof your Immune System Course • Dr. Berg's Beginner Guide to Healthy Keto & Intermittent Fasting Plan • Intermittent Fasting Basics for Beginners • Dr. Berg's Healthy Ketogenic Diet Basics: Step 1: https://youtu.be/vMZfyEy_jpI Step 2: https://youtu.be/mBqpaAKtnXE I explain how important your intestinal mucosal barrier is. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C

On this week's episode of Immunology and Beyond Dr. Puja Bagri joins us to discuss her career path from completing her Ph.D. in mucosal immunity to being a Project Analyst at the Institute of Infection and Immunity. Dr. Bagri completed her Ph.D. at McMaster University where she used mouse models to understand the role of estrogen in affecting anti-viral responses within the female reproductive tract. Stay tuned as we also discuss the importance of seizing opportunities and much more!

Wizzwatch Stock Market Podcast Vol. 98Stock 2 Watch 02.10.2021 $PAND$PAND - Pandion Therapeutics, Inc.INFOBlogger - wizzwatch.blogspot.comFacebook - wizzwatch stock trading groupTwitter - wizzwatchPinterest - wizzwatchLinkedin - marlinrolleDiscord - wizzwatchInstagram - wizzwatchABOUT WIZZWATCHWizzWatch is the place for active traders as well as individual investors to find the very best stocks on Wall St. We provide commentary, picks of the week, as well as stocks on the move. "We find the very best stocks to fit your investment objectives". We cover thousands of publicly traded companies that trade on the NASDAQ,OTCBB, Pink Sheets and the NYSE. We have the answers for your stock market day to day questions. If you have a question about a publicly traded company, and would like to find out more, feel free to ask or send an email to wizzwatch@gmail.com.BECOME A STUDENT If you are interested in finding out more information or learning how to trade stocks please feel free to send me a message via email at wizzwatch@gmail.com. DISCLAIMERLegal Disclaimer: This channel is solely for informational purposes. Past performance is no guarantee of future returns. Stock trading involves risk, the stocks listed are not buy recommendations please do your own due diligence or get help from a proffesional before trading.HASHTAGS#pand #pandiontherapeutics #autoimmune #biotechnology, #biotech #medicine #disease #cures #medication #caccines #massachusetts #protien #treatments #mucosal #vascular #bloodcells #tissues #gasdtrointestine #stocks #stockmarket #investing #investors #thefuture #technicalanalysis #wizzwatch #marlinrolle #medicine #hospitalization

Hello everyone, welcome to episode 60!Yes, SIX-ZERO. Can't believe we made it this far. Please continue to support the show and also go subscribe to your favorite podcast streaming app so you can be the first to know when an episode drops. My guest today is Chikondi Peno who is from Malawi now studying in Scotland. In this episode, we learn that her interest in science came in during her secondary school. She excelled in the science subjects and then went on to take do a BSc degree at undergrad level. After finishing her first degree she wanted to explore the world of research and started working at Malawi Liverpool Welcome Trust. She got a scholarship from the trust and went on to pursue a Masters degree in infectious diseases. She's now a PhD student at Edinburgh University supported by the National Institute of Health and Research Unit on Mucosal pathogens (NIHR-MPRU) in the UK. This PhD research is focused on  respiratory microbe and respiratory health, specifically in children in The Gambia, Africa. Chikondi tells us about this research and its importance. Further, we discuss how being an international student and being far away from home during the pandemic. The mental challenges and dealing with the anxiety related to worrying about your loved ones. We talk about so many more topics. Do join usTwitter : @Chiko_penoInstagram: Chiko PenoLinkedIn: Chikondi Peno Support the show (https://paypal.me/RootofSciPod?locale.x=en_US)

#178 Debbie is a naturopath, herbalist and integrative psychotherapist, a mother, a lover, a gardener, a forager and general nerd. She is a busy clinician and lecturer in the health sciences for over 15 years both in Australia and the UK.  Her work centres on what it is to be human, and how relationships (human, natural and microbial) shape who we are. She currently works for Invivo Healthcare UK as a part of the a part of the Clinical Education team and the Product Development team, where she spends her time helping to educate clinicians in an ecosystem approach to their clients and working in research and development. In this episode we cover The importance of the mucosal barriers throughout the GIT system and their role in immunity The importance of host-microbiome reactions and how host markers such as sIgA and beta defensins help determine our interplay with microbes The bacteria involved in the mucosal balance The importance of syntrophy, and what patterns we commonly see when things start to go in the wrong direction How the thinning of mucosal barriers from the oral cavity to gut play a role in the development of chronic disease The importance of maintaining diversity and syntrophy – both in the human and the wider ecosystem How we can support the mucosal barrier and diversity And so much more

Digestive issues seem to be the norm these days—from food intolerances to gut dysbiosis to SIBO. All we really want to do is eat real food and absorb its nutrients. Enter Dr. Ashley Turner, a Board-Certified Doctor of Holistic Health and traditionally-trained naturopath.  Today, Ashley offers some simple suggestions for restoring our gut health and overall wellbeing. She explains the gut/brain connection and how a leaky gut can lead to mood shifts, allergies, anxiety, migraines, and autoimmune conditions. She reviews steps we can take to reset the gut, including a change of diet, following the GAPS diet or AIP (autoimmune protocol). And she suggests a number of ways we can minimize wear and tear on the body that compromises gut health and our mental health, as well. Visit Ashley's website for more info: restorativechiro.com Check out our sponsor: Ancestral Supplements  Find more resources on our website: westonaprice.org Register for our conference at wisetraditions.org   

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.18.304071v1?rss=1 Authors: Narasimhan, R. L., Throm, A. A., Koshy, J. J., Saldanha, K. M. R., Chandranpillai, H., Lal, R. D., Kumravat, M., Kumar K M, A., Batra, A., Zhong, F., Liu, J. Abstract: Inflammatory bowel disease (IBD) is a complex, chronic inflammatory disease of the gastrointestinal tract with subtypes Crohn's disease (CD) and ulcerative colitis (UC). While evidence indicates IBD is characterized by alterations in the composition and abundance of the intestinal microbiome, the challenge remains to specify bacterial species and their metabolites associated with IBD pathogenesis. By the integration of microbiome multi-omics data and computational methods, we provide analyses and methods for the first time to identify microbiome species and their metabolites that are associated with the human intestine mucosal immune response in patients with CD and UC at a systems level. First, we identified seven gut bacterial species and seventeen metabolites that are significantly associated with Th17 cellular differentiation and immunity in patients with active CD by comparing with those obtained in inactive CD and non-IBD controls. The seven species are Ruminococcus gnavus, Escherichia coli, Lachnospiraceae bacterium, Clostridium hathewayi, Bacteroides faecis, Bacteroides vulgatus, and Akkermansia muciniphila, and a few associated metabolites include the secondary bile acid lithocholate and three short-chain fatty acids (SCFAs): propionate, butyrate, and caproate. We next systematically characterized potential mechanistic relationships between the Th17-involved metabolites and bacterial species and further performed differential abundance analysis for both microbiome species and their metabolites in CD and UC relative to non-IBD controls with their metagenomic and metabolomic data. Based on the deconvolution of immune cell compositions from host intestinal bulk RNA-seq, we investigated changes in immune cell composition and abundance in CD and UC in comparison to non-IBD controls. Finally, we further extended our species and metabolite associations with immune cells from Th17 and Th2 cells to B cells, plasma B cells, CD4+ T cells, and CD8+ T cells. While a set of associations of immune cells with bacterial species and metabolites was supported by published evidence, the new findings in this work will help to furthering our understanding of immune responses and pathogenesis in IBD. Copy rights belong to original authors. Visit the link for more info

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - https://shop.drberg.com/veggie-solution-flavored-sweetened?utm_source=Podcast&utm_medium=AGM(Anchor) • Plain (Unflavored) - https://shop.drberg.com/veggie-solution-plain?utm_source=Podcast&utm_medium=AGM(Anchor) Take Dr. Berg's Free Keto Mini-Course! In this podcast, I want to cover the importance of the intestinal mucosal barrier. What is the intestinal mucosal barrier? — It's simply a barrier between the inside of your colon (the large bowel) and the colon cells. The large bowel is all about fermenting fiber. Most of your friendly bacteria should exist in the large bowel. Mucosal barrier functions: 1. First line of defense 2. Antibacterial 3. Place to ferment fiber 4. Selective absorption 5. Lubrication Microbes eat fiber and turn into small-chain fatty acids (butyrate). Benefits of butyrate: • Feeds colonocytes • It's an anti-inflammatory • Improves insulin resistance • It's anti-cancer • It has satiety properties • It helps maintain the thickness of the mucosal layer Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast&utm_medium=Anchor TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast&utm_medium=Post&utm_campaign=Daily%20Post YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast&utm_medium=Anchor DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast&utm_medium=Anchor MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast&utm_medium=Anchor DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast&utm_medium=Anchor

Gastrointestinal meds. Mucosal protectant. Free quiz & full course at https://Simplenursing.com/nursing-school  Pharmacology Master Class - 100 videos not on YouTube - Try it for Free!    Pharmacology Master Class - Try it for Free: https://Simplenursing.com/nursing-school  100 videos not on YouTube    FREE Access to new app + 1,000 videos not on youtube!  https://Simplenursing.com/nursing-school   NCLEX FREE TRIAL:  https://simplenursing.com/NCLEX   STAY IN TOUCH

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Jacques Bergman who is Professor of Gastrointestinal Endoscopy at the Amsterdam University Medical Center, Amsterdam on "Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study" published in paper copy in Gut in February 2020. Accessible online here: https://gut.bmj.com/content/69/2/295

Monday, April 06, 2020: Virus peaking worldwide as CDC projections wrong. Dr. Corsi interviews Dr. Ryan Cole and Dr. Karladine Graves as they continue to fight the Virus War. Fauci and the medocracy continue to place roadblocks in the way of dedicated life savers who place the well being of their patients above their own power and profit. Hydroxychloroquine, zinc, and Vitamin D are the answers. Fauci and his band of bureaucrats are the problem. Tuesday, April 07,2020: Dr Ali Fattom, SVP Vaccine R&D, BlueWillow Biologics RE: Breakthrough Vaccines A COVID-19 vaccine is in development: safe, elicits local mucosal immunity while protectingagainst iInfection, colonization, shedding, and transmission. Systemic immunity may not be enough for highly efficacious respiratory infections. Mucosal immunity facilitated by an intranasal potent and safe adjuvant (NanoVax®), may be a key in: Improving the efficacy of existing vaccines, Developing broadly effective respiratory Vaccines, Introduction of success vaccines for other well-needed respiratory infections Lawrence Sellin Ph.D. retired from the Army as a colonel after 29 years of service in the U.S. Army Reserve. Sellin worked previously at the U.S. Army Medical Research Institute of Infectious Diseases. Colonel Sellin: “Time and additional evidence will show that coronavirus ‘leaked’ from a Chinese laboratory.” Wednesday, April 08, 2020: CDC still wrong on COVID-19; Bernie Sanders Drops Out COVID-19 peaking in the USA, while the CDC and medical establishment continue to block MDs and pharmacists from providing Hydroxychloroquine to patients. Bernie Sanders drops out of Democratic Party race for presidential nomination. Dr. Vladimir Zelenko & Dr Karladine Graves persist in their quest to enable all doctors to immediately treat patients with COVID19 with hydroxychloroquine, zinc sulfate, azithromycin. Thursday, April 09, 2020: Dr Corsi DEEP DIVE Interview 04-09-20 Dr Karladine Graves Dr Ryan Cole Dr Vicki Wooll COVID insanity Dr Corsi Interviews three highly qualified physicians who argue that doctors and communities have the answers, and Washington DC, the FDA, the DCD, and the medocracy are the problem. People die as leftist bureacrats have elbowed their way into control over US. Dr. Karladine Graves, Dr. Ryan Cole, and Dr. Vicki Wooll share their expertice and experience as they find creative and proactive solutions to treat people and prevent the spread of the virus. Meanwhile, Fauci and his minions find new ways to prolong the suffering and ensure the number of bodies will increase. Friday, April 10, 2020: Sith Lord Fauci's Profit Motive To Make The Virus Worse for US I'm SHOCKED! Dr. Fauci has a personal profit motive to explain his unexplainable conduct...fighting so vehemently to block virus cures and prevention while worshipping fake models and future vaccines. It all makes sense when you factor in he is to rake in millions of blood soaked dollars as his patents and other financial insterests come to light. Dr. Ron Paul, former US Representataive from Kentucky, calls on President Trump to fire Dr. Fauci, saying he and other leftists are rising to the level of tyrants ruling over the American people without legal authority. WHO elected Fauci? Nobody...well maybe Hillary Clinton, George Soros, and Bill Gates.Real data, not that used by Fauci and his minions, show that ony 150 Americans have died as a direct result of COVID-19 as all of the others (over 16,000) had pre-existing conditions that may have been the primary causation. A study coming out from Germany shows the mortality rate due to the Plandemic is on 0.37%, five times lower than the numbers being reported. Dr. Ryan Cole emphasized in his interview yesterday with Dr. Corsi that increased testing is key to winning the virus war. Andrew Schlafly discusses the legal issues involving COVID-19

A COVID-19 vaccine is in development: safe, elicits local mucosal immunity while protecting against iInfection, colonization, shedding, and transmission. Systemic immunity may not be enough for highly efficacious respiratory infections . Mucosal immunity facilitated by an intranasal potent and safe adjuvant (NanoVax®), may be a key in: Improving the efficacy of existing vaccines Developing broadly effective respiratory Vaccines Introduction of success vaccines for other well-needed respiratory infections .

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Irene Salinas Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Evolution of mucosal Ig in rainbow trout (Sci Immunol) Fish olfactory neurons mediate rapid immune response (PNAS) Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

The Jing-a-ling, Ting-a-ling, Ring-a-ling lyrics in Christmas songs Yapping about things that don't make a difference in anyone's life When did hands become a symbol of loyalty? Fake loyalty BS Gabrielle Union getting fired for wearing hairstyles that represent her culture M. Night Shymalan's series, Servant, and the series Messiah Some ideas on what you can buy me for Christmas RIP Juice Wrld And everything else And, if you can sing and would like to contribute a one-minute intro song for my podcast: DM me on Twitter or write to me at justanobodypodcast@gmail.com #JustANobodyPodcast  

Dr. Elizabeth Nance received her Ph.D. from Johns Hopkins University in Chemical & Biomolecular Engineering and is now an Assistant Professor at the University of Washington. She leads a research team in the study of nanoparticles that are capable of targeting disease in the brain. Elizabeth has received numerous awards for her groundbreaking work, and was named one of Forbes 30 under 30 in Science in 2015, described as one of the “most disruptive, game-changing and innovating young personalities in science.” In this podcast NBT Scientific Director Megan Roberts interviews Elizabeth about her research in nanotechnology and its application in medical development and delivery. They discuss the potential applications of her work for the diagnosis and treatment of debilitating diseases such as cancer, Alzheimer’s, and Parkinson’s. They also talk about the message behind Elizabeth’s 2016 TED talk on the importance of exploring unfamiliar territory as a catalyst for growth and mastery. Here’s the outline of this interview with Elizabeth Nance: [00:00:41] Book: How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence, by Michael Pollan. [00:06:30] Nanotechnology. [00:11:42] Justin Hanes, PhD. [00:11:51] Mucosal barrier. [00:15:36] Increasing distribution of particles within brain. [00:17:28] Polyethylene glycol. [00:20:39] Diffusion and convection. [00:27:25] Nanoparticles. [00:33:28] Increasing diffusive capability for improved drug efficacy. [00:34:05] Curcumin study: Joseph A., Wood T., Chen C-C., Corry K., Juul S., Snyder J., Parikh P., Nance E. Curcumin-loaded brain penetrating nanoparticles for treatment of neonatal hypoxia-ischemia encephalopathy. In press, Nano Research. [00:35:13] Nanotechnology in cancer. [00:39:10] Generalizing from animal models. [00:46:40] Childhood cerebral adrenoleukodystrophy. [00:48:25] Video: Specializing in Not Specializing | Elizabeth Nance | TEDxUofW. [00:48:53] Interdisciplinary collaboration. [00:53:14] Book: Mindset: The New Psychology of Success, by Carol Dweck, Ph.D. [01:00:02] Freedom to fail. [01:01:45] Blood Chemistry Calculator; Tommy Wood, MD, PhD; Dr. Bryan Walsh. [01:02:06] Machine learning. [01:06:12] nancelab.com; blog; Facebook; Instagram.

Clinical Presentation Incidental finding on routing CBC Petechiae/purpura Mucosal bleeding Epistaxis Gingival bleeding Hematuria Vaginal bleeding 5 Major Causes of Thrombocytopenia Thrombotic Thrombocytopenic Purpura (TTP) Clinical presentation (pentad) Thrombocytopenia Fever Microangiopathic hemolytic anemia “schistocytes” Neurologic abnormalities Renal dysfunction Physiology Low ADAMTS13 results in impaired vWF breakdown Widespread “platelet plugs” Treatment Plasma exchange Hemolytic Uremic Syndrome […]

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy(Nat Rev Dis Prim) Maternal allergen sensitization(J Exp Med) Image credit Letters readon Immune #5 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

These are most important in trauma patients!!! Platelet Disorders Symptoms of SUPERFICIAL bleeding Mucosal bleeding GI bleeding Recurrent epistaxis Thrombocytopenia When the platelets ARE LOW Refer to THIS episode Von-Willebrand disease When the platelets CAN'T BIND Treatment Desmopressin (DDAVP) Causes increase in amount of von-willebrand factor (vWF) available Also causes free water retention Treatment of […]

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guests: Sharon Isern and Scott Michael   Become a patron of TWiV! Links for this episode Hurricane Zika (TWiV 410) 454 Corporation (Wikipedia) Regional Zika update, Americas (PAHO, WHO) Zika virus serum bank (pdf) Zika virus evolution and spread in the Americas (Nature) Multiple introductions of Zika virus in US (Nature) Inhibition of Zika Virus Replication by Wolbachia (J Virol) Zika virus pathogenesis in rhesus macaques unaffected by immunity to dengue virus (Nat Commun) Impact of flavivirus immunity on Zika virus infection in rhesus macaques (PLoS Path) Enhancement of Zika virus pathogenesis by antiflavivirus immunity (Science) No ADE by dengue antibodies in Zika virus patients (Clin Inf Dis) Oropharyngeal mucosal transmission of Zika virus in rhesus macaques (Nat Commun) Letters read on TWiV 454 Weekly Science Picks Dickson - Industrial Scars Kathy - Eclipse info by zipcode Sharon - Michaela’s article in The Conversation Scott - Signal P, Pecaan, Phamerator, DNAmasterAlan - The Eagle Whisperer” (and the Great Big Story channel) Vincent - Bottle Listener Pick Kevin - Tenure track scientist bites the dust Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Host: Lea Ann Chen, MD Guest: Hans Herfarth, MD Recorded on location at the Crohn’s & Colitis Foundation’s Annual Meeting in Orlando, host Dr. Lea Ann Chen, Assistant Professor of Medicine at New York University, discusses goals of therapy in IBD with Dr. Hans Herfarth, Professor of Medicine at University of North Carolina School of Medicine.

Host: Lea Ann Chen, MD Guest: Hans Herfarth, MD Recorded on location at the Crohn’s & Colitis Foundation’s Annual Meeting in Orlando, host Dr. Lea Ann Chen, Assistant Professor of Medicine at New York University, discusses goals of therapy in IBD with Dr. Hans Herfarth, Professor of Medicine at University of North Carolina School of Medicine.

A study in the February issue of Gastroenterology looked at mucosal impedance (MI) patterns in patients with GERD and common nonreflux conditions, to assess MI patterns before and after treatment with proton pump inhibitors and to compare performance.

Today I’m tackling your questions! I love hearing from you all, and I’m so excited to jump right in to address your health concerns and give you wellness-minded solutions. Which foods are great for boosting immunity? Are there natural remedies for hot flashes? What are probiotics? You’ll get those answers and more in today’s Q & A session! You can find show notes and more information by clicking here: http://thedigestiondoctor.com/19

AIDS Seminar with Raina Nakova Fichorova, MD, PhD Associate Professor of Obstetrics, Gynecology & Reproductive Biology Harvard Medical School

Mairi McLean, Gut’s education editor, talks to Xavier Hébuterne, Department of Gastroenterology and Nutrition, Archet Hospital, Nice, and Jean-Frédéric Colombel, Universite Lille Nord de France, about their paper: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol http://bit.ly/10dtab8.

Recent studies have identified mucosal healing as a key prognostic parameter in the management of inflammatory bowel diseases. In this podcast Mairi McLean, education editor for Gut, talks to Marcus Neurath from the University of Erlangen-Nuremberg, and Simon Travis from John Radcliffe Hospital in Oxford, about their systematic review of the clinical studies on mucosal healing. They discuss the effects of anti-inflammatory or immunosuppressive drugs, and the implications of mucosal healing for subsequent clinical management in patients with IBD.See also:Mucosal healing in inflammatory bowel diseases: a systematic review (http://tinyurl.com/bk7tglj)

Dr. James Lee discusses his manuscript A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis. To view the print version of this abstract go to http://tinyurl.com/lbnkmd

Past and ongoing therapeutic concepts for ulcerative colitis have only been moderately successful. A significant proportion of patients with ulcerative colitis will still have to undergo colectomy and overall half of the patients do not achieve sustained remission, leading to impairment of physical and mental health, social life, employment issues and sexual activity. Reluctance to treat patients early on with sufficiently potent drug regimens is obvious. Several popular misconceptions might have led to this situation. First, ulcerative colitis is still considered a more 'benign' disease than Crohn's disease. Furthermore, the general assumption is often that colectomy can 'cure' the disease. Mucosal healing as a therapeutic target has not been widely accepted. Finally, the use of antitumour necrosis factor antibodies in ulcerative colitis has been low because this treatment is considered to be less effective than in Crohn's disease. In the current review we try to disprove these misunderstandings by discussing relevant studies showing how harmful this disease can be and explaining why future studies targeting sustained suppression of inflammation could have an enormous impact on the natural course of the disease. Until these studies are available, we encourage physicians to intensify and maintain treatment until sustained remission and mucosal healing has been reached.

Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis, according to a study in the June CGH. Dr. Kuemmerle speaks to the author of an accompanying editorial, Dr. David T. Rubin

Audio podcast from the 8th Annual SDPA Fall Dermatology Conference in Grapevine, TX. This was “Spectrum of Treatment Alternatives for Mucosal Vesiculobullous Diseases” with Kim Yancey, MD. This session is also available as a download on iTunes through the dermcast podcast page*. Click here to visit the page on iTunes. [...]

Background: Our aim was to examine whether measurement of the saliva mast cell tryptase (MCT) concentrations before and after a mucosal challenge test with the offending food would be helpful in diagnosing food allergy. Methods: We performed a retrospective analysis of 44 food challenge tests performed in 38 patients between 2006 and 2009. Patients with a suspected history of food allergy chewed the food until they developed symptoms or until the amount of time known from the patients' history to usually be required for the provocation of symptoms had passed. In 5 patients, saliva samples for the measurement of MCT were collected at minutes 0, 1, 4, 8, 11, and 16 after the first onset of symptoms. The remainder of the patients only had samples taken before chewing and 4 min after the end of the test period. Results: During repeated measurements, MCT peaked about 4 min after the onset of symptoms (p = 0.028). During 33 of the 44 tests (75.0%), we observed oral symptoms during testing; after 25 of the 33 (75.8%) tests evoking symptoms, the saliva MCT concentration increased. The MCT increase was negative in all other tests where no oral symptoms could be provoked. Conclusions: The measurement of saliva MCT 4 min after the onset of symptoms may be helpful to diagnose food allergy. Because of numerous confounding variables, however, a negative saliva MCT increase does not exclude food allergy. Copyright (C) 2011 S. Karger AG, Basel

The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination with a platinum-based chemotherapy. Since the antibody has only a limited effect as a monotherapy, possible explanations for the synergistic effect with cisplatin are enhanced antibody-dependent cytoxicity and increased sensitivity to the drug. Most of our knowledge of EGFR biology in HNSCC is based on studies using EGFR inhibitors and/or antibodies. Our study was designed to evaluate the impact of EGFR stimulation on cisplatin-induced DNA damage. Therefore, tissue cultures were produced of tumor-free oropharyngeal mucosa biopsies of HNSCC patients and controls. In a previous study, overexpression of EGFR in tissue cultures from tumor patients compared to controls was confirmed by immunohistochemical staining. Twenty-four-hour stimulation of tissue cultures with transforming growth factor alpha (TGF-alpha), a specific EGFR ligand, resulted in a reduction of cisplatin-induced DNA damage by 35% in cases, whereas in controls TGF-alpha had no effect. This reflects a statistically significant increase in cellular chemoresistance to cisplatin following TGF-alpha stimulation and helps to further understand effects of EGFR antisense therapy in combination with chemotherapy. Copyright (C) 2010 S. Karger AG, Basel

You have no idea what BVD/MD stands for? Then this podcast is made for you. But Professors Joe Brownlie and Dirk Werling will also be able to give those who have heard about Bovine Viral Diarrhoea and Mucosal Disease before an insight into how their work will transform the strategies to fight this major disease in the livestock sector and how it might even have implications for human medicine.

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