Podcasts about proceedings

Featuring perspectives from Drs Yohann Loriot, Elizabeth Plimack and Jonathan Rosenberg, including the following topics: Introduction (0:00) Current and Future Management of Localized Urothelial Bladder Cancer (UBC) (2:59) First-Line Treatment for Patients with Metastatic UBC (mUBC) (28:29) Later-Line Therapeutic Options for Patients with mUBC: Novel Investigational Strategies (47:08) CME information and select publications

In this episode of the Epigenetics Podcast, we caught up with John Rinn from the University of Colorado in Boulder to talk about his work on the role of lncRNAs in gene expression and nuclear organization. The Rinn Lab pioneered the approach of screening the human genome for long noncoding RNAs (lncRNAs). More recently, the lab has shifted focus from measuring the number of lncRNAs to finding lncRNAs that have a distinct biological function in human health and disease. One example of such a lncRNA is FIRRE, which is present in all animals, however the sequence is not conserved, except for in primates. FIRRE contains many interesting features, such as repeat sequences and CTCF binding sites. In absence of FIRRE, defects in the immune system can be observed and also some brain defects may also be observed.   References Carter, T., Singh, M., Dumbovic, G., Chobirko, J. D., Rinn, J. L., & Feschotte, C. (2022). Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo. eLife, 11, e76257. Advance online publication. https://doi.org/10.7554/eLife.76257 Long, Y., Hwang, T., Gooding, A. R., Goodrich, K. J., Rinn, J. L., & Cech, T. R. (2020). RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nature Genetics, 52(9), 931–938. https://doi.org/10.1038/s41588-020-0662-x Kelley, D., & Rinn, J. (2012). Transposable elements reveal a stem cell-specific class of long noncoding RNAs. Genome biology, 13(11), R107. https://doi.org/10.1186/gb-2012-13-11-r107 Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., Regev, A., Lander, E. S., & Rinn, J. L. (2009). Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proceedings of the National Academy of Sciences, 106(28), 11667–11672. https://doi.org/10.1073/pnas.0904715106 Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., Cabili, M. N., Jaenisch, R., Mikkelsen, T. S., Jacks, T., Hacohen, N., Bernstein, B. E., Kellis, M., Regev, A., Rinn, J. L., & Lander, E. S. (2009). Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature, 458(7235), 223–227. https://doi.org/10.1038/nature07672   Related Episodes The Role of lncRNAs in Tumor Growth and Treatment (Sarah Diermeier) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Featuring perspectives from Drs Ian Flinn, Brian Hill, John Leonard, Matthew Lunning, Laurie Sehn and Mitchell Smith, including the following topics: Introduction (0:00) Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) — Ian W Flinn, MD, PhD (3:07) Relapsed/Refractory CLL; Novel Investigational Strategies — Mitchell R Smith, MD, PhD (32:31) Treatment for Follicular Lymphoma — John P Leonard, MD (57:24) Management of Mantle Cell Lymphoma — Matthew Lunning, DO (1:21:22) Caring for Patients with Diffuse Large B-Cell Lymphoma — Laurie H Sehn, MD, MPH (1:44:40) Chimeric Antigen Receptor T-Cell Therapy — Brian T Hill, MD, PhD (2:10:26) CME information and select publications

Stress appears to weaken and age your immune system. In a new study published in the Proceedings of the National Academy of Sciences, researchers at the University of Southern California analyzed questionnaire responses from over 5,700 adults over the age of 50. Participants discussed their lifestyle and professional stresses, traumatic events and discrimination. The researchers […] The post 218. Stress ages and weakens your immune system appeared first on Dr. David Geier - Feel and Perform Better Than Ever.

California lawyer, husband and father A.J. Gokcek shares his updated experiences with the return of the masks, Stanford University observations and interactions, representing parents in court regarding protesting against the masks in schools and the police response.  He also discusses his son's excellent homeschooling experience, and we discuss much more.

This week's conversation is with Mary Helen Immordino-Yang, a Professor of Education, Psychology, Human Development and Neuroscience at the University of Southern California. Mary Helen studies the psychological and neurobiological development of emotion and self-awareness of adolescents in educational settings. Since earning her doctorate from Harvard in 2005, she has received numerous awards for her research and impact on education and society, including an Honor Coin from the U.S. Army, a Commendation from the County of Los Angeles, and a Cozzarelli Prize from the Proceedings of the U.S. National Academy of Sciences.Currently, Mary Helen is conducting several funded, multiyear neurobiological research studies on adolescent students and their teachers. In this conversation we discuss how students really learn, and what we can do to enhance how we teach in an education system. But Mary Helen's insights extend far beyond the educational setting – those with a deep understanding of the role emotion plays in human development will have a distinct advantage for just about any endeavor one is interested in – whether that be as a modern leader, a parent or coach, athlete or teammate. And that's why I wanted to roll up my sleeves with Mary Helen.-----Please support our partners!We're able to keep growing and creating content for YOU because of their support. We believe in their mission and would appreciate you supporting them in return!!To take advantage of deals from our partners, head to http://www.findingmastery.net/partners where you'll find all discount links and codes mentioned in the podcast.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Scientists have discovered the world's largest plant off the Australia coast — a seagrass meadow that has grown by repeatedly cloning itself. Genetic analysis has revealed that the underwater fields of waving green seagrass are a single organism covering 70 square miles (180 square kilometers) through making copies of itself over 4,500 years. The research was published in Proceedings of the Royal Society B. Scientists confirmed that the meadow was a single organism by sampling and comparing the DNA of seagrass shoots across the bed, wrote Jane Edgeloe, a study co-author and marine biologist at the University of Western Australia. A variety of plants and some animals can reproduce asexually. There are disadvantages to being clones of a single organism — such as increased susceptibility to diseases — but “the process can create ‘hopeful monsters'” by enabling rapid growth, the researchers wrote. The scientists call the meadow of Poseidon's ribbon weed “the most widespread known clone on Earth," covering an area larger than Washington. Though the seagrass meadow is immense, it's vulnerable. A decade ago, the seagrass covered an additional seven square miles, but cyclones and rising ocean temperatures linked to climate change have recently killed almost a tenth of the ancient seagrass bed. This article was provided by The Associated Press.

Featuring perspectives from Drs Javier Cortés, Matthew Goetz, Erika Hamilton, Ian Krop, Hope Rugo and Sara Tolaney, including the following topics: Introduction (0:00) Optimizing the Management of ER-Positive Localized Breast Cancer — Matthew P Goetz, MD (7:50) New and Novel Treatment Strategies for Localized Triple-Negative Breast Cancer (TNBC) — Erika Hamilton, MD (38:35) Considerations in the Care of Patients with Localized HER2-Positive Breast Cancer — Ian E Krop, MD, PhD (56:03) Evolving Clinical Decision-Making for Patients with HER2-Positive Metastatic Breast Cancer (mBC) — Javier Cortés, MD, PhD (1:18:47) Selection and Sequencing of Therapy for ER-Positive, HER2-Negative mBC — Hope S Rugo, MD (1:40:41) Recent Advances in the Care of Patients with Metastatic TNBC — Sara M Tolaney, MD, MPH (2:11:40) CME information and select publications

Proceedings at the much anticipated Pan African Parliament have been delayed due to load shedding in Midrand Johannesburg. The election of PAP new leadership was scheduled to have begun at 9am but could not go ahead following the to power outage. Pan African Parliament member, Pemmy Majodina says this area should have been exempted from load shedding. Earlier, Malawian member of the Pan African Parliament, Yeremiah Chihana called on the continent to follow the rules of African Union.  Sakina Kamwendo spoke to SABC reporter, Khaya Khumalo.... 

Recently, a high profile case was reported involving Emilia Hanafi, the ex-wife of businessman Datuk SM Faisal SM Nasimuddin Kamal, who was sentenced to seven days in prison for contempt of court after disobeying an order by unilaterally rescheduling the visitation dates of her three children. This has brought on conversations about the complexity of divorce proceedings within the Syariah legal system. So we first unpack this, and the gaps that exist. Next, we discuss whether reforms are needed and what's needed to be done to push for it. Image Source: Faizal Ramli, Shutterstock

Featuring perspectives from Drs Tanios Bekaii-Saab, Kristen Ciombor, Eileen O'Reilly, Philip Philip, John Strickler and Prof Eric Van Cutsem, including the following topics: Introduction (0:00) Integration of targeted therapy and immunotherapy into the management of metastatic colorectal cancer — Kristen K Ciombor, MD, MSCI (3:15) Other considerations in the management of early and advanced colorectal cancer — John Strickler, MD (33:15) Current and future treatment paradigm for gastroesophageal cancers — Eric Van Cutsem, MD, PhD (55:26) Selection and sequencing of therapy for advanced hepatocellular carcinoma — Philip A Philip, MD, PhD, FRCP (1:23:00) Novel treatment strategies for advanced biliary tract cancers — Tanios Bekaii-Saab, MD (1:50:31) CME information and select publications

Featuring perspectives from Ms Paula Anastasia, Dr Robert Coleman, Dr David O'Malley and Ms Jaclyn Shaver, including the following topics: Introduction (0:00) Management of Endometrial Cancer (5:32) Treatment for Cervical Cancer (45:31) COVID-19: Considerations in Cervical and Endometrial Cancer (1:22:34) Oncology 2032 Crystal Ball (1:27:43) CME information and select publications

What do monkeys, rats, worms, and humans all have in common? We all need physical touch to survive and thrive. Today we discuss attachment and the role it plays in human development. References: Harlow, H. F. (1959). Love in infant monkeys. Scientific American, 200(6), 68-75. Ardiel, E. L., & Rankin, C. H. (2010). The importance of touch in development. Paediatrics & child health, 15(3), 153-156. Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998). Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proceedings of the National Academy of Sciences, 95(9), 5335-5340. --- Support this podcast: https://anchor.fm/noggin-psychologypodcast/support

Featuring perspectives from Drs Antonio González-Martín, Joyce Liu and Kathleen Moore, including the following topics: Introduction (0:00) Clinical Management of Advanced Ovarian Cancer (2:23) Novel Treatments and Strategies Under Investigation (46:04) CME information and select publications

This episode is part two of my miniseries on the neuroscience of language production and processing and today we're touching on how the brain regions encoding those concepts change in deaf individuals. It turns out that the brain is the literal embodiment of that "its free real estate" meme and vision input takes over the auditory cortex!If you're curious to know more - come and take a listen!Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! CDC. Genetics of Hearing Loss | CDC. Centers for Disease Control and Prevention. Published February 18, 2015. https://www.cdc.gov/ncbddd/hearingloss/genetics.html#:~:text=50%25%20to%2060%25%20of%20hearingDeafness causes before birth | Deafness in childhood. www.ndcs.org.uk. https://www.ndcs.org.uk/information-and-support/childhood-deafness/causes-of-deafness/#:~:text=Deafness%20can%20also%20be%20causedSimon M, Campbell E, Genest F, MacLean MW, Champoux F, Lepore F. The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes. Frontiers in Neuroscience. 2020;14. doi:10.3389/fnins.2020.00206Sharma A, Dorman MF, Spahr AJ. A Sensitive Period for the Development of the Central Auditory System in Children with Cochlear Implants: Implications for Age of Implantation. Ear and Hearing. 2002;23(6):532-539. https://journals.lww.com/ear-hearing/Abstract/2002/12000/A_Sensitive_Period_for_the_Development_of_the.4.aspxVoss P, Thomas ME, Cisneros-Franco JM, de Villers-Sidani É. Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery. Frontiers in Psychology. 2017;8. doi:10.3389/fpsyg.2017.01657Purves D, Augustine GJ, Fitzpatrick D, et al. The Auditory Cortex. Nih.gov. Published 2016. https://www.ncbi.nlm.nih.gov/books/NBK10900/Bola Ł, Zimmermann M, Mostowski P, et al. Task-specific reorganization of the auditory cortex in deaf humans. Proceedings of the National Academy of Sciences. 2017;114(4):E600-E609. doi:10.1073/pnas.1609000114‌Fougnie D, Cockhren J, Marois R. A common source of attention for auditory and visual tracking. Attention, Perception, & Psychophysics. 2018;80(6):1571-1583. doi:10.3758/s13414-018-1524-9Campbell R, MacSweeney M, Waters D. Sign Language and the Brain: A Review. The Journal of Deaf Studies and Deaf Education. 2008;13(1):3-20. doi:10.1093/deafed/enm035Support the show

Featuring perspectives from Drs Andrew Armstrong, Alan Bryce and Alicia Morgans, including the following topics: Introduction (0:00) Case: A man in his early 70s with DIPSS low- to intermediate-risk post-essential thrombocythemia myelofibrosis (MF) — Warren S Brenner, MD (5:29) Case: A woman in her late 60s with primary MF who experiences disease progression after 3 years of ruxolitinib — Jeanne Palmer, MD (17:19) Case: A woman in her late 60s with disease progression after multiple regimens for post-polycythemia vera MF — Neil Morganstein, MD (30:51) A woman in her late 70s with post-PV MF with a JAK2 V617F mutation and transfusion dependence — Bhavana (Tina) Bhatnagar, DO (39:33) Case: A man in his mid 60s with primary MF with a JAK2 mutation and recurrent herpes zoster reactivation on ruxolitinib — Niyati A Nathwani, MD (50:23) Case: A man in his early 70s with prefibrotic primary MF with a JAK2 mutation and ruxolitinib-associated HPV reactivation — Susannah Friemel, MD (53:36) Case: A man in his early 20s with myeloproliferative neoplasm with a JAK2 V617F mutation and thrombocytosis — Rajni Sinha, MD, MRCP (57:16) CME information and select publications

Partners, Brendan Bowles and Lena Wang, and Director of Research, Markus Rotterdam, discuss the 2022 Annotated Construction Act and Conduct of Lien, Trust and Adjudication Proceedings texts available from Thomson Reuters Canada Limited. Key updates to the books are discussed and commentary on their development is given.This podcast was recorded remotely in adherence with Glaholt Bowles LLP's social distancing policy and recommendations from the Government of Ontario and Government of Canada.For more information, please visit our website at www.glaholt.com.The information and views expressed in this podcast are for information purposes only, are not intended to provide legal advice, and do not create a lawyer client relationship. For specific advice, please contact us.

Featuring perspectives from Drs Courtney DiNardo, Michael Savona and Eunice Wang, including the following topics: Introduction (0:00) Selection of therapy for older and younger patients with acute myeloid leukemia (AML) (2:05) Therapy for patients with AML with targetable mutations (33:42) Current and future management of myelodysplastic syndromes (49:04) CME information and select publications

Photo: 2/2: ClassicKenCroswell:  Remembering the Voyager Twins: The Voyager Twins chatting for eternity. Ken Croswell. The Lives of Stars.   Ken Croswell.  The Lives of Stars. Proceedings of the National Academy of Sciences:  https://www.pnas.org/content/118/17/e2106371118

Photo: 1/2: ClassicKenCroswell:  Remembering the Voyager Twins: The Voyager Twins chatting for eternity. Ken Croswell. The Lives of Stars.   Ken Croswell.  The Lives of Stars. Proceedings of the National Academy of Sciences:  https://www.pnas.org/content/118/17/e2106371118

The gang discusses two papers that look at the co-evolution of plants and herbivores. The first paper finds the earliest evidence of a unique type of insect herbivory in the fossil record, and the second looks at the evolutionary impact of the extinction of large herbivores on palm trees. Meanwhile, Curt recovers from COVID round 2, Amanda is a static character, and James finds that getting what he wants is almost worse than not getting it at all.   Up-Goer Five (Curt Edition): Our friends talk about things that live in the ground and make their own food but are not able to move (like a tree and other things) and also the animals that eat these things. Some small animals eat the parts of trees that catch the sun but have this stuff that is supposed to get these small animals stuck if they try and eat these parts of the tree. The way that these small animals do this is either by cutting off the stuff that would get them stuck and then eating the rest of these parts that grab sun. We know that trees and other things like trees started to use this stuff a long time ago. This paper finds the first time that we know of in which these small animals were able to cut off the stuff that would get them stuck. They used the same ideas in the past that they use today, and it happened pretty close to when trees and other things like them started to use this stuff. This means that the trees and the small animals that eat them were changing with each other. The second paper looks at how a type of tree that is not a real tree changed when the large animals that could have eaten it were not there. The people who wrote this paper had ideas about what changes could have happened when these not trees didn't have large animals around to eat them, but it turns out to have been a little different from what they might have thought. These not trees stopped making parts that would stop animals from eating them, but they didn't stop making big food. This might mean that big food is not just something that big animals can use, and that maybe small animals were eating the food and that would help the not tree to move its babies around.   References: Onstein, Renske E., W. Daniel  Kissling, and H. Peter Linder. "The megaherbivore gap after the  non-avian dinosaur extinctions modified trait evolution and  diversification of tropical palms." Proceedings of the Royal Society B 289.1972 (2022): 20212633. McCoy, Victoria E., et al. "Oldest fossil evidence of latex sabotaging behavior by herbivorous insects." Review of Palaeobotany and Palynology 300 (2022): 104631.

Humans have understood how to calculate the length of a day pretty accurately for a long time. But there wasn't a standard way to approach time on a global scale until the late 19th century, and happened because of railroads. Research: “INTERNATIONAL CONFERENCE HELD AT WASHINGTON FOR THE PURPOSE OF FIXING A PRIME MERIDIAN AND A UNIVERSAL DAY.” (Protocols of the Proceedings.” October 1884. https://www.gutenberg.org/files/17759/17759-h/17759-h.htm Fleming, Sandford. “Terrestrial time: a memoir.” 1876. Digitized: https://archive.org/details/cihm_06112/page/n17/mode/2up Fleming, Sandford. “Papers on time-reckoning and the selection of a prime meridian to be common to all nations.” 1879. Digitized: https://archive.org/details/cihm_03135/page/n17/mode/2up Creet, Mario. “FLEMING , Sir SANDFORD.” Dictionary of Canadian Biography. http://www.biographi.ca/en/bio.php?id_nbr=7370 Creet, Mario. “Sandford Fleming and Universal Time.” Scientia Canadensis. Volume 14, numéro 1-2 (38-39). https://www.erudit.org/fr/revues/scientia/1990-v14-n1-2-scientia3118/800302ar.pdf Shepardson, David. “U.S. Senate approves bill to make daylight saving time permanent.” Reuters. March 16, 2022. https://www.reuters.com/world/us/us-senate-approves-bill-that-would-make-daylight-savings-time-permanent-2023-2022-03-15/ “What Shall Be the Prime Meridian for the World?” International institute for preserving and perfecting weights and measures. Committee on standard time.  Cleveland, O., 1884. https://babel.hathitrust.org/cgi/pt?id=mdp.39015019895203&view=1up&seq=8 Biggerstaff, Valerie. “Opinion: When Georgia had two time zones.” Appen Media. April 14, 2021. https://www.appenmedia.com/opinion/opinion-when-georgia-had-two-time-zones/article_0bb3e6c4-9c84-11eb-a1f5-6b1a42a8e61a.html Lange, Katie. “Daylight Saving Time Once Known As 'War Time.'” U.S. Department of Defense. March 8, 2019. https://www.defense.gov/News/Feature-Stories/story/Article/1779177/daylight-saving-time-once-known-as-war-time/ “DID BEN FRANKLIN INVENT DAYLIGHT SAVING TIME?” The Franklin Institute. https://www.fi.edu/benjamin-franklin/daylight-savings-time “United States Congressional Serial Set.” U.S. Government Printing Office. Volume 2296. 1885. Accessed online: https://play.google.com/store/books/details?id=_1JHAQAAIAAJ&rdid=book-_1JHAQAAIAAJ&rdot=1 Rosenberg, Matt. "The History and Use of Time Zones." ThoughtCo, Aug. 27, 2020, thoughtco.com/what-are-time-zones-1435358. “The New Railroad Time.” New York Times. Oct. 12, 1883. https://timesmachine.nytimes.com/timesmachine/1883/10/12/106260579.pdf?pdf_redirect=true&ip=0 Glass, Andrew. “President Wilson signs Standard Time Act, March 19, 1918.” Politico. March 19, 2018. https://www.politico.com/story/2018/03/19/wilson-signs-standard-time-act-march-19-1918-467550 Britannica, The Editors of Encyclopaedia. "Sir Sandford Fleming". Encyclopedia Britannica, 3 Jan. 2022, https://www.britannica.com/biography/Sandford-Fleming “History of Time Zones.” Bureau of Transportation Statistics. Feb. 21, 2021. https://www.bts.gov/geospatial/time-zones Gordon, Nicholas. “The Senate wants to make daylight saving time permanent—but that could leave Americans with less sleep and worse health.” Fortune. March 16, 2022. https://fortune.com/2022/03/16/daylight-saving-time-sleep-senate-protecting-sunshine-act/ “Public Law 89-387 – An ACT To promote the observance of a uniform system of time throughout the United States.” April 13, 1966. https://www.govinfo.gov/content/pkg/STATUTE-80/pdf/STATUTE-80-Pg107.pdf See omnystudio.com/listener for privacy information.

Featuring perspectives from Ms Lesley Camille Ballance, Ms Amy Goodrich, Dr Lowell Hart and Dr Anthony Mato, including the following topics: Introduction (0:00) Overview of Chronic Lymphocytic Leukemia (5:47) Bruton Tyrosine Kinase Inhibitors (27:40) Venetoclax and Anti-CD20 Antibody Therapy (58:59) Future Strategies (1:15:51) NCPD information and select publications

This lecture was given on March 24, 2022 at the University of Florida. For more information on upcoming events, please visit our website at www.thomisticinstitute.org. About the speaker: Fr. Nicanor Austriaco, O.P., completed his Bachelor's Degree (B.S.E.) in Bioengineering, summa cum laude, at the University of Pennsylvania, and then earned his Ph.D. in Biology from M.I.T. in the laboratory of Professor Leonard Guarente, where he was a fellow of the Howard Hughes Medical Institute (HHMI). He was ordained a priest in the Order of Preachers in May of 2004. He completed his Pontifical License in Sacred Theology (S.T.L.) in Moral Theology, summa cum laude, at the Dominican House of Studies in Washington, DC, in 2005, and a Pontifical Doctorate in Sacred Theology (S.T.D.), magna cum laude, at the University of Fribourg in Switzerland, in 2015. Fr. Austriaco currently serves as Professor of Biology and of Theology at Providence College in Providence, Rhode Island. His NIHfunded laboratory at Providence College is investigating the genetics of programmed cell death using the yeasts, Saccharomyces cerevisiae and Candida albicans, as model organisms. Papers describing his research have been published in PLoS ONE, FEMS Yeast Research, Microbial Cell, Cell, the Journal of Cell Biology, and the Proceedings of the National Academy of Sciences USA, among others. In philosophy and theology, his essays have been published in the National Catholic Bioethics Quarterly, Theological Studies, Nova et Vetera, The Thomist, Science and Theology, and the Linacre Quarterly. His first book, Biomedicine and Beatitude: An Introduction to Catholic Bioethics, was published by the Catholic University of America Press in 2011. It was recognized as a 2012 Choice outstanding academic title by the Association of College and Research Libraries.

Featuring perspectives from Ms Monica Averia, Dr Shilpa Gupta, Ms Brenda Martone and Dr Sumanta Kumar Pal, including the following topics: Introduction (0:00) Management of Localized Urothelial Bladder Cancer (UBC): Adjuvant Treatment, TAR-200 (6:47) Management of Metastatic UBC: Antibody-Drug Conjugates, Checkpoint Inhibitors (33:00) Management of UBC with an FGFR Mutation (57:37) Oncology/UBC 2032 and a Crystal Ball (1:19:52) NCPD information and select publications

In this episode I speak about online learning systems and why blindly choosing such a paradigm can lead to very unpredictable and expensive outcomes. Also in this episode, I have to deal with an intruder :)     Links Birman, K.; Joseph, T. (1987). "Exploiting virtual synchrony in distributed systems". Proceedings of the Eleventh ACM Symposium on Operating Systems Principles - SOSP '87. pp. 123–138. doi:10.1145/41457.37515. ISBN 089791242X. S2CID 7739589.  

Featuring perspectives from Ms Ilene Galinsky and Dr Eunice Wang, including the following topics: Introduction (0:00) Younger patients with acute myeloid leukemia (AML) (2:11) Older patients with AML (34:45) Treatment for myelodysplastic syndromes (49:57) NCPD information and select publications

Back on the podcast, today is sleep, nutrition, and metabolism expert, Greg Potter, PhD. Through his academic research, public speaking, consulting and writing, Greg empowers people to make simple and sustainable lifestyle changes that add years to their lives and life to their years. His work has been featured in dozens of international media outlets, including Reuters, TIME, and The Washington Post, and he regularly contributes to popular websites, blogs, and podcasts. In this podcast, Greg is talking about light, including the importance of getting out in the sun and also modern problems with artificial light. He discusses the impact of light on the circadian system along with up-to-date recommendations related to light hygiene. We discuss practical tips for reducing light at night (not all of which involve putting away your device), and why not getting the right kind of light might be keeping you from achieving your body composition goals. Here's the outline of this episode with Greg Potter:  [00:02:14] Wellics Corporate Wellness Software. [00:06:49] The importance of light. [00:08:30] The introduction of electric light. [00:09:55] myLuxRecorder (Satchin Panda's app, no longer available); Podcast: How to Use Time-Restricted Eating to Reverse Disease and Optimize Health, with Satchin Panda. [00:10:37] How light influences the circadian system. [00:15:34] Consensus paper with recommendations related to light hygiene; Study: Brown, Timothy M., et al. "Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults." PLoS biology 20.3 (2022): e3001571. [00:19:13] Practical tips for reducing light at night. [00:22:44] Increasing prevalence of myopia. [00:23:46] Podcast: Getting Stronger, with Todd Becker. [00:26:01] Vitamin D synthesis; Podcast: The Pleiotropic Effects of Sunlight, with Megan Hall. [00:26:15] Effects of light on mood and cognition. [00:27:24] Effect of light exposure patterns on cognitive performance; Study: Grant, Leilah K., et al. "Daytime exposure to short wavelength-enriched light improves cognitive performance in sleep-restricted college-aged adults." Frontiers in neurology (2021): 197. [00:28:14] Effects of light on metabolic health. [00:28:20] Dan Pardi podcast featuring Peter Light: Sunlight And Fat Metabolism: A New Discovery. [00:28:52] Effect of bright and dim light on metabolism (Netherlands); Study: Harmsen, Jan-Frieder, et al. "The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day." Diabetologia 65.4 (2022): 721-732. [00:30:53] Effects of light on skin and immune function. [00:31:57] Highlights #15 (topics: Sun avoidance & exposure, increasing testosterone, Robert Sapolsky). [00:35:14] Skyglow. [00:36:48] Light at night and endocrine disruption. [00:37:45] Light at night and quality/duration of sleep. [00:38:19] Blue light in the evening interferes with sleep homeostasis; Study: Cajochen, Christian, et al. "Evidence that homeostatic sleep regulation depends on ambient lighting conditions during wakefulness." Clocks & Sleep 1.4 (2019): 517-531. [00:38:53] Effects of light at night on sympathetic nervous system/cortisol; Study: Rahman, Shadab A., et al. "Characterizing the temporal dynamics of melatonin and cortisol changes in response to nocturnal light exposure." Scientific reports 9.1 (2019): 1-12. [00:39:26] Effects of light at night on heart rate, HRV, insulin resistance; Study: Mason, Ivy C., et al. "Light exposure during sleep impairs cardiometabolic function." Proceedings of the National Academy of Sciences 119.12 (2022): e2113290119. [00:41:34] Effects of moon phases on sleep; Study: Casiraghi, Leandro, et al. "Moonstruck sleep: Synchronization of human sleep with the moon cycle under field conditions." Science advances 7.5 (2021): eabe0465. [00:45:40] Effects of individual sensitivity to light; Study: Phillips, Andrew JK, et al. "High sensitivity and interindividual variability in the response of the human circadian system to evening light." Proceedings of the National Academy of Sciences 116.24 (2019): 12019-12024. [00:47:55] Camping and melatonin synthesis across seasons; Study: Stothard, Ellen R., et al. "Circadian entrainment to the natural light-dark cycle across seasons and the weekend." Current Biology 27.4 (2017): 508-513. [00:48:40] Seasonal changes in thyroid hormones (meta-analysis): Kuzmenko, N. V., et al. "Seasonal variations in levels of human thyroid-stimulating hormone and thyroid hormones: a meta-analysis." Chronobiology International 38.3 (2021): 301-317. [00:53:24] Effect of location in the world; Podcast: Morning Larks and Night Owls: the Biology of Chronotypes, with Greg Potter, PhD. [00:54:30] Daylight Savings Time transition and  traffic accidents in the US; Study: Fritz, Josef, et al. "A chronobiological evaluation of the acute effects of daylight saving time on traffic accident risk." Current biology 30.4 (2020): 729-735. [00:56:08] Effects of Daylight Savings Time on cardiac events. [00:56:48] Daylight Savings Time and cyberloafing; Study: Wagner, David T., et al. "Lost sleep and cyberloafing: Evidence from the laboratory and a daylight saving time quasi-experiment." Journal of Applied psychology 97.5 (2012): 1068.  [00:57:26] Circadian clock disrupted by Daylight Savings Time; Study: Kantermann, Thomas, et al. "The human circadian clock's seasonal adjustment is disrupted by daylight saving time." Current Biology 17.22 (2007): 1996-2000.  [01:00:44] Implications of permanent daylight savings time. [01:03:37] Effects of light at night in animals; Study: Sanders, Dirk, et al. "A meta-analysis of biological impacts of artificial light at night." Nature Ecology & Evolution 5.1 (2021): 74-81. [01:09:14] Minimizing the impact of light at night on wildlife. [01:13:50] Human-centric lighting at hospitals; Study: Giménez, Marina C., et al. "Patient room lighting influences on sleep, appraisal and mood in hospitalized people." Journal of sleep research 26.2 (2017): 236-246. [01:14:51] Babies in a neonatal unit did better with light/dark cycle; Study: Vásquez-Ruiz, Samuel, et al. "A light/dark cycle in the NICU accelerates body weight gain and shortens time to discharge in preterm infants." Early human development 90.9 (2014): 535-540. [01:17:59] Effects of light at night on plants; Study: Ffrench-Constant, Richard H., et al. "Light pollution is associated with earlier tree budburst across the United Kingdom." Proceedings of the Royal Society B: Biological Sciences 283.1833 (2016): 20160813. [01:18:50] Maturation of soybeans shifted with  artificial light at night; Study: Palmer, Matthew, et al. Roadway lighting's impact on altering soybean growth. No. FHWA-ICT-17-010. 2017. [01:19:44] How to optimise your light environment. [01:19:54] Incandescent vs compact fluorescent bulbs. [01:21:58] LED lights. [01:25:33] Light-emitting devices with screens; metamerism. [01:26:20] Using metamerism to regulate impact of digital devices; Study: Allen, Annette E., et al. "Exploiting metamerism to regulate the impact of a visual display on alertness and melatonin suppression independent of visual appearance." Sleep 41.8 (2018): zsy100. [01:26:51] Software that reduces your exposure to short wavelengths: Nightshift (iPhone), Night Light/Blue Light Filter (Android), f.lux. [01:27:23] Apps to prevent short-wavelength light emissions do help; Study: Gringras, Paul, et al. "Bigger, brighter, bluer-better? Current light-emitting devices–adverse sleep properties and preventative strategies." Frontiers in public health 3 (2015): 233. [01:27:31] Blue-light blocking app did not improve sleep; Study: Smidt, Alec M., et al. "Effects of Automated Diurnal Variation in Electronic Screen Temperature on Sleep Quality in Young Adults: A Randomized Controlled Trial." Behavioral Sleep Medicine (2021): 1-17. [01:28:31] Blue-blockers. [01:31:31] Recommendations for shift workers. Greg's paper on this topic: Potter, Gregory DM, and Thomas R. Wood. "The future of shift work: Circadian biology meets personalised medicine and behavioural science." Frontiers in Nutrition 7 (2020): 116. [01:33:34] Jet lag: Jet Lag Rooster. [01:37:27] Find Greg on Instagram, TikTok; gregpotterphd.com [01:37:56] Book: When Brains Dream: Understanding the Science and Mystery of Our Dreaming Minds, by Antonio Zadra. [01:38:08] Book: The Beginning of Infinity: Explanations That Transform the World, by David Deutsch. [01:38:32] Book: The Precipice by Toby Ord.

Host Bill Bray sits down with First Lieutenant David Alman, Alabama Air National Guard, to discuss his prize-winning essay in the June issue of Proceedings.

The latest Naval History edition of the Proceedings podcast commemorates the 80th anniversary of the Battle of Midway, with acclaimed Midway historian Jonathan Parshall.

Today, Justin Beamis sits down with Dr. Benjamin Levi, M.D. to discuss his life, his research, and the incredible work he and his team at U.T. Southwest Medical are doing with the donations made by everyone who supports Sons of the Flag! Benjamin Levi, M.D., is an Associate Professor in the Department of Surgery at UT Southwestern Medical Center. He holds the Dr. Lee Hudson-Robert R. Penn Chair in Surgery and Plastic and Reconstructive Surgery and serves as Division Chief of Burn, Trauma, Acute and Critical Care Surgery. He specializes in acute and reconstructive burn surgery and scar reconstructive surgery. He is the author of more than 100 scholarly articles, including high-impact papers in Science Translational Medicine, Proceedings of the National Academy of Sciences, and Nature Communications, as well as chapters in a number of textbooks, including Greenfield's Surgery, Total Burn Care, Grabb and Smith's Plastic Surgery, and Trauma. He has delivered presentations worldwide, held numerous invited professorships, and serves as a permanent editor and ad hoc editor for journals in his area of research. Dr. Levi co-chairs the Reconstructive Special Interest Group of the American Burn Association. He is also a member of the American College of Surgeons, the American Council of Academic Plastic Surgeons, the American Society for Bone and Mineral Research, the American Society of Plastic Surgeons, the Association for Academic Surgery, the Reed O. Dingman Society, and the Plastic Surgery Research Council. Sponsored by Magnegrip and Tencate.    

In this podcast episode, MRS Bulletin's Laura Leay interviews Michael Dickey from North Carolina State University about his work manipulating liquid gallium. When submerged in an aqueous solution, liquid gallium will form a sphere. When fed by gravity through a thin nozzle that is surrounded by aqueous solution, it will instead flow into the shape of a wire. Passing an electrical current through the liquid metal wire means that a magnetic field is created, which means the wire can be shaped using external magnets, following the Lorentz force. This research was published in a recent issue of the Proceedings of the National Academy of Sciences (doi:10.1073/pnas.2117535119).   

Featuring perspectives from Ms Marianne Davies, Dr Matthew Gubens, Dr Lowell Hart and Ms Chaely Medley, including the following topics: Introduction (0:00) Overview of Small Cell Lung Cancer (SCLC) (6:42) First-line Therapy and Prevention of Cytopenias (25:03) Second Line and Beyond (1:04:33) SVC (Superior Vena Cava), SIADH (Syndrome of Inappropriate Antidiuretic Hormone) and Other Paraneoplastic Syndromes (1:20:25) Complementary Treatments (1:25:57) NCPD information and select publications

Welcome to episode three of a miniseries focusing on the zooarchaeology of various world regions. This episode is centered around American zooarchaeology, focusing on the natural history and anatomy of the most prominent wild and domesticated species found throughout North and South America. Tune in for beaver-pretenders, bison-cattle hybrids and even more moose/elk arguments! Interested in learning about how to use X-Rays and similar technology in archaeology? Check out the linked PaleoImaging course from James Elliot! Connect with James on Twitter: @paleoimaging Interested in sponsoring this show or podcast ads for your business? Zencastr makes it really easy! Click this message for more info. Start your own podcast with Zencastr and get 30% off your first three months with code ANIMALS. Click this message for more information. For rough transcripts of this episode go to https://www.archpodnet.com/animals/47 Links Anning, C. (2011) Inca success in Peruvian Andes 'thanks to llama dung'. BBC News. Crader, D. C. (1997). Prehistoric use of beaver in coastal Maine (USA). Anthropozoologica, 25(26), 225-236. - Halbert, N. et al. (2007). "Where the buffalo roam: The role of history and genetics in the conservation of bison on U.S. federal lands". Park Science. 24 (2): 22–29. Hirst, K.K. (2018) Llamas and Alpacas: The Domestication History of Camelids in South America. ThoughtCo. Hubbard, T. (2014). Buffalo Genocide in Nineteenth-Century North America. Colonial genocide in indigenous North America, 292-305. Petrigh, R. S., & Fugassa, M. H. (2013). Molecular identification of a Fuegian dog belonging to the Fagnano Regional Museum ethnographic collection, Tierra del Fuego. Quaternary International, 317, 14-18. Miller, G. R. (2003). Food for the dead, tools for the afterlife: Zooarchaeology at Machu Picchu. In Burger, R. L., and Salazar, L. C. (eds.), The 1912 Yale Peruvian Scientific Expedition Collections from Machu Picchu: Human and Animal Remains. Saunders, N. J. (1994). Predators of Culture: Jaguar Symbolism and Mesoamerican Elites. World Archaeology, 26(1), 104–117. Speller, C. F. et al. (2010). "Ancient mitochondrial DNA analysis reveals complexity of indigenous North American Canham domestication". Proceedings of the National Academy of Sciences. 107 (7): 2807–2812. Turner, B. L., and Armelagos, G. J. (2012). "Diet, residential origin, and pathology at Machu Picchu, Peru". American Journal of Physical Anthropology. 149 (1): 71–83. https://historicjamestowne.org/collections/artifacts/faunal-material/ https://blog.nature.org/science/2017/11/20/tracing-the-wild-origins-of-the-domestic-turkey/ Contact Alex FitzpatrickTwitter: @archaeologyfitz Simona FalangaTwitter: @CrazyBoneLady Alex's Blog: Animal Archaeology Music "Coconut - (dyalla remix)" https://www.youtube.com/watch?v=_2UiKoouqaY Affiliates Wildnote TeePublic Timeular Motion

Welcome to episode three of a miniseries focusing on the zooarchaeology of various world regions. This episode is centered around American zooarchaeology, focusing on the natural history and anatomy of the most prominent wild and domesticated species found throughout North and South America. Tune in for beaver-pretenders, bison-cattle hybrids and even more moose/elk arguments! Interested in learning about how to use X-Rays and similar technology in archaeology? Check out the linked PaleoImaging course from James Elliot! Connect with James on Twitter: @paleoimaging Interested in sponsoring this show or podcast ads for your business? Zencastr makes it really easy! Click this message for more info. Start your own podcast with Zencastr and get 30% off your first three months with code ANIMALS. Click this message for more information. For rough transcripts of this episode go to https://www.archpodnet.com/animals/47 Links Anning, C. (2011) Inca success in Peruvian Andes 'thanks to llama dung'. BBC News. Crader, D. C. (1997). Prehistoric use of beaver in coastal Maine (USA). Anthropozoologica, 25(26), 225-236. - Halbert, N. et al. (2007). "Where the buffalo roam: The role of history and genetics in the conservation of bison on U.S. federal lands". Park Science. 24 (2): 22–29. Hirst, K.K. (2018) Llamas and Alpacas: The Domestication History of Camelids in South America. ThoughtCo. Hubbard, T. (2014). Buffalo Genocide in Nineteenth-Century North America. Colonial genocide in indigenous North America, 292-305. Petrigh, R. S., & Fugassa, M. H. (2013). Molecular identification of a Fuegian dog belonging to the Fagnano Regional Museum ethnographic collection, Tierra del Fuego. Quaternary International, 317, 14-18. Miller, G. R. (2003). Food for the dead, tools for the afterlife: Zooarchaeology at Machu Picchu. In Burger, R. L., and Salazar, L. C. (eds.), The 1912 Yale Peruvian Scientific Expedition Collections from Machu Picchu: Human and Animal Remains. Saunders, N. J. (1994). Predators of Culture: Jaguar Symbolism and Mesoamerican Elites. World Archaeology, 26(1), 104–117. Speller, C. F. et al. (2010). "Ancient mitochondrial DNA analysis reveals complexity of indigenous North American Canham domestication". Proceedings of the National Academy of Sciences. 107 (7): 2807–2812. Turner, B. L., and Armelagos, G. J. (2012). "Diet, residential origin, and pathology at Machu Picchu, Peru". American Journal of Physical Anthropology. 149 (1): 71–83. https://historicjamestowne.org/collections/artifacts/faunal-material/ https://blog.nature.org/science/2017/11/20/tracing-the-wild-origins-of-the-domestic-turkey/ Contact Alex FitzpatrickTwitter: @archaeologyfitz Simona FalangaTwitter: @CrazyBoneLady Alex's Blog: Animal Archaeology Music "Coconut - (dyalla remix)" https://www.youtube.com/watch?v=_2UiKoouqaY Affiliates Wildnote TeePublic Timeular Motion

In this Naval History edition of the Proceedings podcast, as Sam Tangredi takes us back to the Middle Ages to explore a fascinating, and largely overlooked, topic: the role of maritime operations in the Great Crusades. Captain Tangredi will talk about “one of history's first specialized amphibious assault ships.”

The gang discusses two papers which use morphology to infer behavior in the fossil record. The first paper looks at the origins of the “killer whale” type morphology in fossil cetaceans, and the second paper describes the earliest example of a diurnal owl in the fossil record. Meanwhile, James proposes an unconventional workforce, Curt imagines the sea mammal revolution, and Amanda cuts the crap… out of her basement.   Up-Goer Five (Curt Edition): Our friends talk about two papers that look at how things look and how we can use that to tell how animals might have lived in the past. The first paper looks at a group of animals with hair that breathe air but live their whole lives in water and do not have legs. There are lots of different types of these animals but one of these animals is named after being someone that kills. However, there is another group of these animals that look a lot like these animals that are named after killing but are not the same. This paper finds a really old one of these animals that looks like but is not one of these killing animals. These animals have things that make them eat in different ways than most of the animals with hair that live in water. This older animal may be the first time that these animals with hair who live in water were eating in this way. It also shows that this type of body that looks like these animals that are named for killing really did appear many times within the group. The second paper looks at animals who fly that are usually out at night and kill very quietly. They find a very old one of these animals that is very complete and allows them to see lots of parts of the animal we usually do not get. These parts show that this animal may have actually been moving around during the day instead of at night, like most of the other animals in this group. They show that moving around in the day is something that a few of these animals today do and that it has appeared many times in the past. This animal might be the oldest one of these animals that lived in the day, and shows that, even though most of these animals today are out at night, the group has a lot more going on with whether or not these animals were out in the day or at night.   References: Li, Zhiheng, et al. "Early evolution  of diurnal habits in owls (Aves, Strigiformes) documented by a new and  exquisitely preserved Miocene owl fossil from China." Proceedings of the National Academy of Sciences 119.15 (2022): e2119217119. Bianucci, Giovanni, et al. "The origins of the killer whale ecomorph." Current Biology (2022).

Links1. "Don't Buy Warships (Yet)," by David Alman, Proceedings, June 2022.2. Sea Control 303: The Case for Seaplanes with David Alman, CIMSEC, December 19, 2021.3. “The Navy Needs More Firepower,” by T.X. Hammes, USNI Proceedings, January 20214. “From Sea to Sky,” by David Alman, CIMSEC December 10, 2019.5. Sea Control 219: USCG Commandant Admiral Karl Schultz, CIMSEC, December 27, 2020.6. “DARPA Unveils Liberty Lifter Seaplane Concept,” Naval News, May 19, 2022.

You may be wondering if you can strike a debt repayment deal with your creditors without going to a Licensed Insolvency Trustee and a formal insolvency filing. Well, it depends on how much you owe, who you owe, your assets, and lots of other factors. On today's podcast, Doug Hoyes and Ted Michalos walk you through all the different scenarios in which you could deal with creditors by yourself, the risks to that, benefits, and they discuss when filing a consumer proposal or bankruptcy is the better option. Tune in! Related Links: Can I Negotiate a Debt Settlement on My Own: https://www.hoyes.com/blog/can-i-negotiate-a-debt-settlement-on-my-own/ Negotiating Consumer Proposals – What Your Creditors Expect: https://www.hoyes.com/blog/negotiating-consumer-proposals-what-your-creditors-are-expecting/ Bankruptcy Protection in Canada: An Automatic Stay of Proceedings: https://www.hoyes.com/blog/bankruptcy-protection-in-canada-an-automatic-stay-of-proceedings/

Major Brian Kerg, USMC, 2021 Proceedings Author of the Year, talks about his prize-winning Leadership Essay “Leading Through Defeat” in the April issue.

Retired Navy Admiral Harry Harris, former U.S. Ambassador to South Korea and PACOM Commander, discusses security challenges on the Korean Peninsula and across the broader Indo-Pacific region.

Videos : 1. Introducing The Reset: The Great Reset Docuseries (Start @ 0:30) 2. Welcome to 2030 this is agenda for humans 3. WEF – Anything Will Be Put in A Body  (1:24) 4. The social contract has been broken by the few of the State, says Neil Oliver (9:35) 5. Fake Meat, Fake Breastmilk and Food Shortages – Allison Royal (11:38) 6. Good news! WHO Pandemic ‘Treaty' voted down (6:09) 7. Carl Sagan's views about science (1:22) 8. How to speak Bidenese – by:  Not the Bee  (3:04) Vegan diet might ease diabetic nerve pain Lenox Hill Hospital (NYC), May 28th, 2022  A vegan diet might help people with diabetes-related nerve damage shed weight and find some pain relief, a small pilot study suggests. In the new study, researchers tested whether a vegan diet could help people with type 2 diabetes and painful nerve damage in their feet or hands. The investigators found that over 20 weeks, the 17 people they assigned to the diet lost an average of 15 pounds. At the same time, blood flow to their feet improved and their pain eased up. The dieters were told to limit themselves to 20 to 30 grams of fat per day, and to load up on “low GI” foods, which are foods that do not cause a large surge in blood sugar. Breakfast might include oatmeal with raisins, Wells said, while dinner could be lentil stew, or a vegetable stir-fry with rice.  After about five months, the vegan group had lost 15 pounds, on average, versus about 1 pound in the comparison group. They also reported bigger improvements on a standard pain-rating survey. (Next) About 3 grams a day of omega-3 fatty acids may lower blood pressure, more research needed  Macau University of Science and Technology (China) About 3 grams daily of omega-3 fatty acids, consumed in foods or supplements, appears to be the optimal daily dose to help lower blood pressure, according to a research review published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association. According to our research, the average adult may have a modest blood pressure reduction from consuming about 3 grams a day of these fatty acids,” said study author Xinzhi Li, M.D., Ph.D., at Macau University of Science and Technology in Macau, China. Researchers analyzed the results of 71 clinical trials from around the world published from 1987 to 2020.  The analysis found: Compared to adults who did not consume EPA and DHA, those who consumed between 2 and 3 grams daily of combined DHA and EPA omega-3 fatty acids (in supplements, food or both) had reduced systolic (top number) and diastolic (bottom number) blood pressure by an average 2 mm Hg. Consuming more than 3 grams of omega-3 fatty acids daily may have added blood pressure-lowering benefit for adults with high blood pressure or high blood lipids: At 3g a day of omega-3s, systolic blood pressure (SBP) decreased an average of 4.5 mm Hg for those with hypertension, and about 2 mm Hg on average for those without. At 5g a day of omega-3s, SBP declined an average of nearly 4 mm Hg for those with hypertension and less than 1 mm Hg on average for those without. (Next) When is the best time of day to exercise? The answer may be different for men and women Skidmore College When should I fit exercise within my daily schedule? For most, the answer depends on our family's schedule and working hours, and perhaps on whether we're “larks” or “night owls.” But over the past decade, researchers have found that much more hangs on this question than these constraints. That's because recent findings suggest that the effectiveness of exercise depends on the time of day (Exercise Time Of Day, ETOD). Now, a randomized controlled trial not only confirms convincingly that ETOD affects the effectiveness of exercise, but also shows that these effects differ between types of exercise, and between women and men. Principal investigator Dr. Paul J Arciero, a professor at the Health and Human Physiological Sciences Department  said: “Here we show for the first time that for women, exercise during the morning reduces belly fat and blood pressure, whereas evening exercise in women increases upper body muscular strength, power, and endurance, and improves overall mood and nutritional satiety.” (Next) Diabetes may weaken teeth and promote tooth decay Rutgers University, May 31, 2022 People with both Type 1 and Type 2 diabetes are prone to tooth decay, and a new study from Rutgers may explain why: reduced strength and durability of enamel and dentin, the hard substance under enamel that gives structure to teeth. Researchers induced Type 1 diabetes in 35 mice and used a Vickers microhardness tester to compare their teeth with those of 35 healthy controls over 28 weeks. Although the two groups started with comparable teeth, enamel grew significantly softer in the diabetic mice after 12 weeks, and the gap continued to widen throughout the study. Significant differences in dentin microhardness arose by week 28. (Next) Could beating drums help beat autism? King's College London, June 1, 2022 The percussive skill needed to bang out rhythms on a drum may help improve socializing, inhibition control and focus among teens with autism, new research suggest The finding follows work with 36 teens with an autism spectrum disorder. Half were randomly chosen to receive two months' worth of drum training, based on a standard electronic drum kit program. The upshot: Learning to drum appeared to reduce hyperactive behavior and improve teens' ability to focus and pay attention, she said. The activity also seemed to enhance communication “between brain regions responsible for inhibitory control, action-outcome monitoring, and self-regulation.” Drumming requires “motor planning and timing accuracy” as well as focused attention and inhibition control.  Those assigned to drum training were given two 45-minute sessions a week for eight weeks. The other group received no drum training.The findings were published online May 31 in the Proceedings of the National Academy of Sciences.

Lauren and JJ share some important clinical updates including a study about client perception of veterinary attire, guidelines from the FDA regarding veterinary drug compounding, updates for appropriate patient cooling in heatstroke cases, and the use of continuous glucose monitoring in diabetic cases. References and Resources: 1. The study on veterinary attire: E. Bentley, H. Kellihan, C. Longhurst, & R. Chun. (2020). Effect of attire on client perceptions of veterinarians. The Veterinary Journal, 265(1), 105550. https://doi.org/10.1016/j.tvjl.2020.105550 2. VIN News article on the FDA guidelines for veterinary drug compounding: Lau, E. (April 21, 2022). FDA finishes veteirnary drug compounding guidance at last. VIN News Service. https://news.vin.com/default.aspx?pid=210&Id=10904160 3. Link to the FDA document, "Compounding Animal Drugs from Bulk Drug Substances:" https://news.vin.com/apputil/image/handler.ashx?docid=10887416 4. Link to the FDA document, "List of Bulk Drug Substances for Compounding Office Stock Drugs for Use in Nonfood-Producing Animals:" https://www.fda.gov/animal-veterinary/animal-drug-compounding/list-bulk-drug-substances-compounding-office-stock-drugs-use-nonfood-producing-animals 5. Link to the FDA's information regarding reporting adverse drug events, including Form 1932a: https://www.fda.gov/animal-veterinary/animal-drug-compounding/list-bulk-drug-substances-compounding-office-stock-drugs-use-nonfood-producing-animals 6. Sources for heatstroke clinical updates: (1) Wells RJ: Environmental emergencies. Western Veterinary Conference Proceedings. February 2012, 19-23. Las Vegas, NV. https://www.vin.com/members/cms/project/defaultadv1.aspx?id=5604141&pid=11348& (2) Brashear M: Canine heat stroke – Keeping your cool. Pacific Veterinary Conference Proceedings. June 2019, 21-24. Long Beach, CA. https://www.vin.com/members/cms/project/defaultadv1.aspx?id=9048897&pid=23140& (3) Carr M: The Pathophysiology and Treatment of Heat Stroke. International Veterinary Emergency and Critical Care Symposium 2003. https://beta.vin.com/members/cms/project/defaultadv1.aspx?id=3848363&pid=11162& (4) Bruchim Y: Canine Heatstroke: Patient Management. International Veterinary Emergency and Critical Care Symposium 2016. https://www.vin.com/members/cms/project/defaultadv1.aspx?id=7480469&pid=15793& (5) Waxman C: Temperature extremes: From hypothermia to heatstroke. New York Vet Show Proceedings. November 2019, 7-8. New York, NY. https://www.vin.com/members/cms/project/defaultadv1.aspx?id=9319962&pid=23658& (6) Hemmelgarn C, Gannon K: Heatstroke: clinical signs, diagnosis, treatment, and prognosis. . Compend Contin Educ Vet 2013 Vol 35 (7) pp. E3. https://beta.vin.com/members/cms/document/default.aspx?objecttypeid=2&template=articleview&objectid=1930137&said=1 7. Source for clinical updates regarding continuous blood glucose monitoring in diabetic patients: Lathan, P. A. (2021). Monitoring diabetic dogs and cats. Southwest Veterinary Symposium 2021 Proceedings. 8. Link to Patty Lathan's video on continous glucose monitor application in companion animals: https://www.youtube.com/watch?v=ytkcjpdxtKY

Dr. Derek Hennen works for the Virginia Department of Agriculture as the Slow the Spread Coordinator monitoring the spongy moth populations in the state. He talks to co-host Brian Patrick about his paper inthe April 15th issue of ZooKeys in which he and his coauthors describe 17 new species of millipedes from the eastern United States. We discuss this massive work on millipedes from eastern US, and particularly the group restricted to the Appalachians, how to find millipedes, and how a species named after Taylor Swift got its name! The title of the paper is “A revision of the wilsoni species group in the millipede genus NannariaChamberlin, 1918 (Diplopoda, Polydesmida, Xystodesmidae).” The paper is currently available here: https://zookeys.pensoft.net/article/73485/ To learn more about Derek, follow him on Twitter, @derekhennen, or his millipede account, @DearMillipede. Ricardo Bassini-Silva is an acarologist and post-doctoral researcher in the Department of Pathology at the Universidade Estadual Paulista in Saő Paulo, Brazil. In this episode, he tells us about the new genus of mites he and his coauthors have published in their recent paper in the April issue of the Journal of the Proceedings of the Entomological Society of Washington. We discuss the diversity of mites, the process of taxonomic reclassification, and the wonderful world of ectoparasitism. The title of the paper is “A New Genus for Euschoengastia chisosensis Wrenn, Baccus, and Loomis, 1976 (Trombidiformes: Trombiculidae).” The paper is currently available here: https://doi.org/10.4289/0013-8797.123.4.693 To learn more about Ricardo Bassini-Silva and his work, follow him on instagram @RicardoBassini. Be sure to follow New Species on Twitter (@PodcastSpecies), like the podcast page on Facebook (https://www.facebook.com/NewSpeciesPodcast), and music in this podcast is "No More (Instrumental)," by HaTom (https://fanlink.to/HaTom). If you would like to support this podcast: https://www.patreon.com/NewSpeciesPodcast

Annie and Jenny discover how Skye's greatest mountains are the remains of an ancient volcano. We unravel rich Scottish folklore about Beinn na Caillich: the Mountain of the Old Woman. We discuss the lore of giant women who battled across the sea with giant boulders.  Learn about Saucy Mary, a lost Norwegian Princess and, a fake Norwegian Princess. If you love Skye, this episode is filled with magical mountain lore.  You can support Stories of Scotland on Patreon! www.patreon.com/storiesofscotland This is part of the Radical Mountain Women, funded by the Royal Society of Literature. References: Anderson, J., 1873. Notes of some Entries in the Iceland Annals regarding the Death of the Princes Margaret. Proceedings of the Society of Antiquaries of Scotland, 10.  Finlayson, J. (Contributor), Maclean C. I. (Fieldworker), 1955. Mar a fhuair Beinn Na Caillich aim, SA1955.169, The School of Scottish Studies Archives, University of Edinburgh.  Gordon, S., 1927. A Peak in Skye: Beinn na Cailliche. The Scotsman.  Hull, E., 1927. Legends and Traditions of the Cailleach Bheara or Old Woman (Hag) of Beare. Folklore, 38. Kallestrup, L. and Toivo, R., 2017. Contesting Orthodoxy in Medieval and Early Modern Europe. Cham: Springer International Publishing: Palgrave Macmillan. Macculloch, J. and Scott, W., 1824. The Highlands and western Isles of Scotland in letters to Sir Walter Scott. London. MacKay, J., 1905. How Beinn na Callaiche got it's name. Celtic Monthly, Glasgow, 13.  Mackenzie, D. A., 1905. A Highland Goddess. The Celtic Review, 7, no. 28.  Whyte, A., 2021. The Cailleach in Place-Names and Place-Lore. Journal of Scottish Name Studies, 14.

Featuring perspectives from Drs Raoul Concepcion, Fred Saad and Matthew Smith, moderated by Dr Emmanuel Antonarakis, including the following topics: Introduction (0:00) Management Approaches for Nonmetastatic Prostate Cancer — Raoul S Concepcion, MD (3:00) Role of Treatment Intensification in Metastatic Hormone-Sensitive Prostate Cancer — Matthew R Smith, MD, PhD (31:55) Selection and Sequencing of Therapy for Metastatic Castration-Resistant Prostate Cancer — Emmanuel S Antonarakis, MD (1:00:03) Current and Future Integration of PARP Inhibitors in the Management of Prostate Cancer — Fred Saad, MD (1:30:29) CME information and select publications

Featuring perspectives from Drs Matthew Galsky, Ashish Kamat and Stephen Williams, moderated by Dr Sumanta Kumar Pal, including the following topics: Introduction (0:00) Available Data with and Ongoing Investigation of Novel Agents and Strategies for Non-Muscle-Invasive Bladder Cancer (NMIBC) — Ashish M Kamat, MD, MBBS (2:17) Novel Therapeutic Approaches for Muscle-Invasive Bladder Cancer (MIBC) — Stephen B Williams, MD, MS (33:41) Current and Future Front-Line Management of Metastatic Urothelial Bladder Carcinoma (mUBC) — Matthew D Galsky, MD (1:00:55) Selection and Sequencing of Therapy for Relapsed/Refractory mUBC — Sumanta Kumar Pal, MD (1:43:07) CME information and select publications

Featuring perspectives from Ms Jennifer Filipi, Dr Kathleen Moore, Dr Krishnansu Tewari and Ms Deborah Wright, including the following topics: Introduction (0:00) Primary Ovarian Cancer: Neoadjuvant and Adjuvant Chemotherapy (11:48) PARP Inhibitor Maintenance Therapy (29:29) Adherence in the Maintenance Setting (1:02:06) Novel Strategies and Clinical Trials (1:15:55) NCPD information and select publications

Host Eric Mills sits down with Andrew Blackley to discuss celebrated painter, influential nautical writer, Swedish-born immigrant Henry Reuterdahl. Reuterdahl's work immortalized—and helped improve—the U.S. fleet as it emerged onto the world stage. More here:https://www.usni.org/magazines/naval-history-magazine/2022/june/navys-artist-reform