Podcasts about proceedings

The Lindsay Clancy trial spent a day in the world of lab coats and evidence logs, and it was no less devastating for it. Clancy, 34, of Duxbury, Massachusetts, is accused of strangling her three children — 5-year-old Cora, 3-year-old Dawson, and 7-month-old Callan — with exercise resistance bands inside the family's Summer Street home on January 24, 2023. She faces three counts of murder and three counts of strangulation, has pleaded not guilty, and attorney Kevin Reddington is arguing an insanity defense centered on severe postpartum psychosis and psychiatric overmedication.Plymouth Superior Court Judge William F. Sullivan started afternoon proceedings by reading the stipulations prosecution and defense had already agreed on regarding the children's toxicology findings. Then the state called its scientists. Alicia Zimmermann of the Massachusetts State Police Crime Lab explained how toxicology testing is conducted when the deceased is a child — a process that demands its own protocols, not adult ones scaled down. Sherri Crook, who supervises the State Police Crime Scene Response unit, followed with a breakdown of blood spatter analysis, distinguishing spatter from pooling from smearing, and mapping those categories onto the physical evidence recovered at the Clancy home.This is the unglamorous backbone of a strangulation prosecution — chain-of-custody science, pattern interpretation, and testimony that doesn't editorialize because it doesn't have to. Prosecutors Jennifer Sprague and Shanan Buckingham are using it to build a factual floor under the state's case. The defense still has to get the jury from "this happened" to "she didn't know it was wrong." That gap is where this trial will actually be decided. Proceedings continue in Plymouth Superior Court.LinksJoin Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1Instagram https://www.instagram.com/hiddenkillerspod/Facebook https://www.facebook.com/hiddenkillerspod/Tik-Tok https://www.tiktok.com/@hiddenkillerspodX Twitter https://x.com/TrueCrimePodDisclaimerThis publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health, or legal advice.Hashtags#LindsayClancy #DuxburyTragedy #CrimeLab #TrueCrime #PlymouthCounty #CoraDawsonCallan #InsanityDefense #KevinReddington #ForensicScience #Breaking

Hello Interactors,I've long been a fan of “regreening” cities, imagining replacing bits of asphalt and concrete with trees, plants, mini-parks, and green roofs to cool them down. In many cases these are indeed good interventions. But even these celebrated nature-based solutions to the “urban heat island” effect require closer inspection. It turns out any land cover change alters energy, water, and momentum exchanges between the Earth's surface and the atmosphere. Which are the right ones and where?To understand why cookie cutter greening plans can fail and how planners and policy makers can build cities that can handle climate change, we need to understand how land and the air interact. Environments vary from place to place, and this puts limits on what we can do to land to create urban climates that are both beautiful and healthy.To get a handle on what the research says, I found a literature review from 2025 that synthesized findings from 84 peer-reviewed studies. In was published in the journal Climate Risk Management.Let's see what they, and others, found.BEATING HEAT WITH BIOPHYSICAL FEATSWhat better place to start than science. Let's just delve right into how urban green spaces affect temperature. It starts with determining the energy balance at the surface of the earth. This comes from a budget equation found in physical geography. When sunlight hits the Earth's surface, it breaks down into three main fluxes, or ways heat moves around* Sensible heat flux: the heat that directly warms the surrounding air, which we measure as temperature.* Latent heat flux: the heat that's used to turn water from a liquid to a gas, like when we sweat or plants release water vapor (transpiration).* Ground heat flux: the heat stored in building materials, asphalt, and soil.In conventional urban environments dominated by concrete and asphalt, latent heat flux is minimal because we've built cities in ways that rapidly drain water away as ‘waste'. As a result, incoming solar energy is funneled into sensible heat. This raises daytime air temperatures that gets stored as ground heat, which is slowly radiated back into the city at night. Urban greening can reshuffle this thermodynamic budget through three interconnected physical mechanisms: shading, evapotranspiration, and albedo modification.Mechanism 1. Shading: Intercepting Solar RadiationShading — the most immediate and reliable cooling mechanism provided by vegetation — requires precise microclimatic quantification. Vegetative canopies act as physical shields, intercepting incoming shortwave solar radiation before it strikes impervious surfaces like concrete or asphalt. By preventing these dense materials from absorbing heat and emitting sensible heat flux back into the boundary layer, shading dramatically lowers surface temperatures and reduces the baseline thermal energy transferred to the surrounding air. (Bowler, D. E., et al. 2010)The cooling benefit of urban trees is non-linear, accelerating significantly once neighborhood canopy cover crosses a critical threshold of around 40%. Measuring daytime air temperatures across urban gradients, they found that canopy cover above this 40% mark can lower local air temperatures by up to 1.5 to 2.0 degrees Celsius, effectively offsetting the thermal burden created by surrounding roads and impervious surfaces. (Ziter, C. D., et al. 2019)Mechanism 2. Evapotranspiration: Trading Sensible Heat for Latent HeatWhile shading blocks heat absorption, evapotranspiration actively removes heat from the air. Plants absorb soil moisture through their root systems and release it as water vapor through tiny microscopic pores in their leaves called stomata. This process requires thermal energy that turns phase-changing liquid water into gas. This energy transfer absorbs sensible heat and converts it into latent heat.Evapotranspiration from well-watered urban green spaces can lower local air temperatures by 2-4 degrees celsius. (Coutts, et al., 2013) However, physical geographers emphasize a crucial physical prerequisite that is easy to overlook: evapotranspiration is entirely dependent on available water. When the soil is dry or the air is super dry, plants close their stomata to save water. When stomata close, evapotranspiration shuts down. This leaves shading as the sole remaining cooling mechanism.Mechanism 3. Albedo Dynamics: The Surface Reflectivity ParadoxAlbedo measures the reflectivity of a surface on a scale from 0.0 (total absorption) to 1.0 (total reflection). Urban asphalt has a low albedo (0.05 to 0.10), absorbing up to 95% of incoming solar energy. Vegetation's albedo can range from 0.11 to 0.25.In temperate climates, replacing low-albedo asphalt with greenery or reflective surfaces increases surface reflectivity, sending more solar radiation back into space before it can be absorbed as sensible heat. One study documented that increasing urban surface albedo typically lowers peak ambient air temperatures by 0.3 degres Celsius to 1.0 degree Celsius — alongside much larger drops in surface pavement temperatures. While a temperature change under one degree Celsius may sound modest at first glance, a baseline shift of this magnitude across a neighborhood is enough to redefine a local microclimate. (Santamouris, 2014)But swapping out light urban surfaces for dark vegetation can also have a negative effect. Paradoxically, when researchers in 2023 replaced dry, light-colored desert soil with darker vegetation in hot, arid regions it reduced overall surface reflectivity. The drop in albedo caused an increase in daytime surface warming. (Schlaerth, et al., 2023)Furthermore, dense tree canopies inside narrow urban street canyons can act as thermal blankets at night. While trees provide valuable shade during the day, their foliage reduces the sky view factor at street level, trapping outgoing longwave thermal radiation emitted by surrounding building facades and asphalt. When combined with reduced wind permeability, this canopy barrier restricts nocturnal radiative cooling and holds warm air near ground level (Lee et al., 2016).These are the physical realities that can demonstrate how urban greening is not a consistently inherent cooling practice. It is a complex thermodynamic intervention whose success relies entirely on local environmental conditions.PLACEMENT, PATCHES, AND PARK PATTERNSBecause thermodynamic processes happen across physical spaces, cooling urban green space can be uneven. The literature review reveals that a green space's cooling capacity depends on four spatial and biological variables: vegetation density, species selection, spatial configuration, and urban morphology. Let's break them down individually.Cooling Factor 1. Vegetation Density and Species TraitsNot all greenery cools equally. One way to measure this is through a Leaf Area Index (LAI). This is the total leaf area per unit of ground area and is a primary predictor of thermal performance. As you might imagine, dense foliage absorbs more from the sun and then produces higher cumulative transpiration (so long as there's adequate water).Botanical traits also play a big role. Broadleaf deciduous species (like oaks or maples) feature large surface areas that maximize summer transpiration, but that goes away when they drop their leaves in winter. Evergreen coniferous trees, however, maintain continuous canopy coverage through every season.In temperate rainforest environments like Seattle or Vancouver, researchers found that conifers cooled urban surroundings up to 1.7 degrees celsius more effectively than broadleaf trees. Dense needle canopies continuously block incoming solar radiation due to higher LAI and the fact that clusters of spiny needles better trap a stable buffer of calm air which moderates heat exchange with the surrounding urban environment. (Eyster & Beckage, 2022, 2023) Cooling factor 2. Spatial Configuration: Landscape Ecology PrinciplesEcologists and geographers commonly evaluate green spaces through two main attributes: composition (how much green space exists) and configuration (how those green patches are arranged across the landscape). Over 58% of the mechanism-focused studies in the literature review analyzed spatial pattern metrics. The consensus is the spatial layout of green space is just as important as its total area!Other empirical studies consistently demonstrate that cooling effects decay the further you get from green spaces. Research done in 2016 and 2023 shows how urban parks can produce a primary “cooling footprint” that extends typically 100 to 300 meters from the park boundaries. If you're lucky enough to live within this buffer, temperatures drop between 1.9 and 3.1 degrees celsius, but beyond 300 meters, the cooling influence quickly falls off. (Bao, et al. 2016, Shi et al. 2023)This spatial limit leads to a couple spatial layout choices. A few big parks or connected networks of smaller green spaces. Large, consolidated parks (>2 hectares) generate intense, stable “cool islands” at their core, but their benefits remain localized. For example, a study in Xalapa, Mexico, revealed that parks larger than 2.8 hectares with over 21% tree cover provided reliable local cooling of around 2 degrees celsius . (Lemoine-Rodriguez et al., 2022)Connected networks of smaller green spaces distributed across a city create a more equitable cooling effect. Three studies in 2019 and 2021 show that fragmented, isolated green patches — like big parks — perform poorly compared to continuous, linear green corridors. Linear “green belts” or street-tree networks (in the right environment) can act as ventilation channels, allowing cool air generated by vegetation to flow into adjacent built-up neighborhoods. (Masoudi et al., 2019, 2021; Pramanik, 2019)Cooling factor 3. Urban Morphology: The Built Environment MatrixObviously, green spaces don't exist in isolation. They're embedded within a three-dimensional hodge podge of buildings, streets, and other bits of infrastructure. Urban morphologists can quantify this urban morphological cacophony using building height-to-street-width ratio and sky view factor - the extent to which surrounding structures and canopies obstruct a location's view of the open sky.High-density urban cores with tall buildings create deep “urban canyons” that generate their own shade. In these settings, building shade can combine with tree shade during peak daylight hours to significantly lower temperatures.However, studies show that if tree canopies in narrow street canyons are too dense — particularly in humid environments — they can trap anthropogenic heat emitted by vehicle exhaust and air conditioning condenser units. They can also significantly reduce localized wind speeds. As a result, maximizing green space cooling efficiency requires aligning vegetation density and canopy architecture with prevailing wind corridors to preserve urban ventilation channels (Cheung & Jim, 2019; Morakinyo et al., 2019).Nothing is every as easy as it seems.BRIDGING GAPS WITH BETTER MAPSWhile academic literature can offer detailed insights into microclimatic processes, there remains a big gap between academia and urban planning and governmental policy. That gap may be self-fulfilling. The literature review of 84 papers revealed 61% of the papers simply advocate for expanding green space area, whereas only 26% focus on optimizing existing green infrastructure.Recommending that dense, historical cities “add more large parks” ignores real-world urban constraints. In modern, rapidly expanding cities, urban land is expensive, highly contested, and structurally constrained. Space dedicated to a new park often competes directly with housing, transit infrastructure, or commercial development. To move beyond idealistic slogans, urban planning will have to recon with three major implementation challenges.Challenge 1. The Water-Energy-Heat Nexus in Arid CitiesThe most significant implementation challenge facing nature-based solutions occurs precisely where urban heat stress is most severe — in hot, arid regions. Cities like Phoenix, Cairo, Tehran, or Riyadh already suffer from intense summer heatwaves. You don't have to live in or visit these places to know water there is extremely scarce.Maintaining green spaces in places like this requires pumping groundwater or desalinating seawater. Pumping and desalinating water requires massive amounts of electricity, which only increases greenhouse gas emissions if that power is coming from fossil fuels. Furthermore, if irrigation water runs out during a heatwave, non-adapted vegetation dries out, loses its cooling capacity, and can even become a wildfire risk.To solve this dilemma, physical geographers advocate evaluating urban greening through a standardized resource efficiency metric: evapotranspirative cooling per unit of water applied. In plain language, this ratio measures how many degrees of cooling you get for each liter (or gallon) of water that plants and soil release into the air through evaporation and transpiration.In dry climates — where municipal water is already tightly rationed and turfgrass is increasingly discouraged but rarely banned (I'm looking at you Arizona) — urban greening strategies are going to have pivot away from high-water lawns and non-native foliage. These cities have to move from simply prioritizing or incentivizing drought-tolerant species to requiring them. While drought-tolerant plants transpire less water than many other plants and trees — and still require water — when combined with drip-irrigation using treated municipal wastewater (greywater), they can provide a pretty reliable canopy shade and even modest evaporative cooling without draining water reserves.Challenge 2. Environmental Justice and Thermal EquityUrban heat exposure is rarely, if ever, distributed evenly across socio-economic groups. In many cities worldwide, low-income neighborhoods exhibit significantly lower tree canopy cover, higher proportions of impervious asphalt, and higher building densities than the more affluent suburbs and ex-urbs. This imbalance leaves more vulnerable populations exposed to extreme heat hazards.When municipalities undertake uncoordinated “regreening” projects, they risk triggering green gentrification. Installing fancy attractive parks can then inflate surrounding property values, displacing residents while still not reducing their heat related vulnerability.To address this, requires targeted interventions like deploying small-scale, distributed interventions (think pocket parks, vegetated bus stops, and road corridors) directly in high-vulnerability, low-canopy/vegetation neighborhoods. You could focus on functional shading over high-maintenance aesthetics. This could better ensure that at least transit stops, pedestrian walkways, and playgrounds are prioritized for canopy cover. Lastly, combining situated green infrastructure with social policy could create and/or protect more affordable housing around old and new greened public corridors and spaces.Challenge 3. A Multi-Benefit, Context-Specific Design FrameworkNo single cooling intervention works everywhere. Planners and policy makers need to adopt an integrated, multi-tiered approach that combines nature-based solutions with material interventions.In arid and semi-arid environments, planners should prioritize structural canopy shading and end an over-reliance on water-intensive lawn evapotranspiration. It's time to demand drought-tolerant trees with greywater irrigation networks, shade sails, and high-albedo “cool pavements” that can better reflect solar radiation without draining water resources.In contrast, humid and more temperate climates would likely benefit most from maximizing green spatial connectivity. By linking existing parks through linear street-tree corridors — with select broadleaf and/or coniferous species — summer evapotranspiration can be enhanced while maintaining year-round microclimate regulation.Finally, within high-density, built-up cores where ground space for new parks is limited, cities should leverage vertical green walls and green roofs paired with reflective building materials. But they best also preserve prevailing wind corridors while preventing nighttime heat traps through street canyons.“Regreening” is a compelling slogan, but as physical geography demonstrates, simplistic blanket policies can yield unpredictable thermodynamic results. Simply planting trees without considering local climate, available water, species traits, spatial configuration, and urban geometry can lead to unintended consequences.The exhaustive synthesis of decade-long research provided by Hadi Soltanifard and Majid Amani-Beni (2025) offers a clear path forward. Nature-based solutions are not off-the-shelf products that can be copy-pasted across different global cities. They are dynamic, living interventions that alter energy fluxes across urban surfaces.By moving beyond blanket acreage targets and framing urban greening as the strategic reorganization of surface-energy relations, geographers, urban planners, and policymakers will need to work together. When we design green infrastructure that respects local environmental constraints, honors spatial equity, and optimizes microclimatic processes, urban greening moves from a vague policy promise toward tools of experimentation that can pragmatically evolve our cities and megaregions into truly climate-resilient urbanscapes.ReferencesBowler, D. E., Buyung-Ali, L., Knight, T. M., & Pullin, A. S. (2010). Urban greening to cool towns and cities: A systematic review of the empirical evidence. Landscape and Urban Planning, 97(3), 147-155.Cheung, P.K., Jim, C.Y., 2019. Differential cooling effects of landscape parameters in humid-subtropical urban parks. Landscape and Urban Planning 192, 103651.Coutts, A.M., Tapper, N.J., Beringer, J., et al., 2013. Watering our cities: the capacity for Water Sensitive Urban Design to support urban cooling and improve human thermal comfort in the Australian context. Progress in Physical Geography 37(1), 2–28.Eyster, H. N., & Beckage, B. (2022). Conifers may ameliorate urban heat waves better than broadleaf trees: Evidence from Vancouver, Canada. Atmosphere, 13(5), 830.Eyster, H. N., & Beckage, B. (2023). Arboreal urban cooling is driven by leaf area index, leaf boundary layer resistance, and dry leaf mass per leaf area: Evidence from a system dynamics model. Atmosphere, 14(3), 552.Lee, H., Mayer, H., & Chen, L. (2016). Contribution of trees and grasslands to the mitigation of human heat stress in a residential district of Freiburg, Southwest Germany. Landscape and Urban Planning 148:37–50.Lemoine-Rodríguez, R., Inostroza, L., Falfán, I., & MacGregor-Fors, I. (2022). Too hot to handle? On the cooling capacity of urban green spaces in a Neotropical Mexican city. Urban Forestry & Urban Greening, 74, 127633.Masoudi, M., Tan, P.Y., 2019. Multi-year comparison of the effects of spatial pattern of urban green spaces on urban land surface temperature. Landscape and Urban Planning. 184, 44–58.Masoudi, M., Tan, P.Y., Fadaei, M., 2021. The effects of land use on spatial pattern of urban green spaces and their cooling ability. Urban. Clim 35, 100743.Masoudi, M., Tan, P.Y., Liew, S.C., 2019. Multi-city comparison of the relationships between spatial pattern and cooling effect of urban green spaces in four major Asian cities. Ecol. Indic 98, 200–213.Morakinyo, T.E., Ouyang, W., Lau, K.-K.-L., et al., 2020. Right tree, right place (urban canyon): Tree species selection approach for optimum urban heat mitigation-development and evaluation. Sci. Total. Environ 719, 137461.Pramanik, M. (2019). Impacts of urban expansion on land surface temperature and urban heat island in Kolkata Municipal Corporation, India. Environmental Monitoring and Assessment, 191(12), 738.Santamouris, M. (2014). Cooling the cities—a review of reflective and green roof mitigation technologies to fight heat island and improve comfort in urban environments. Solar Energy, 103, 682-703.Schlaerth, Hannah L., et al. "Albedo as a competing warming effect of urban greening." Journal of Geophysical Research: Atmospheres 128.24 (2023): e2023JD038764.Soltanifard, H., & Amani-Beni, M. (2025). The cooling effect of urban green spaces as nature-based solutions for mitigating urban heat: Insights from a decade-long systematic review. Climate Risk Management, 49, 100731.Ziter, C. D., Pedersen, E. J., Kucharik, C. J., & Turner, M. G. (2019). Scale-dependent interactions between tree canopy cover and impervious surfaces reduce daytime urban heat. Proceedings of the National Academy of Sciences (PNAS), 116(15), 7575-7580. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit interplace.io

Présente du Portugal à la Scandinavie, la mystérieuse culture campaniforme va changer une partie de l'Europe. Qu'était cette population ? Était-ce seulement une population ? Grâce à l'archéologie et à la génétique, partez sur les traces de cette culture qui continue de faire débattre les chercheurs. Oui, tout ça à cause d'un gobelet en forme de cloche.Retrouvez le script, la bibliographie complète et les crédits sonores et graphiques sur : https://ladentbleue.fr/culture-campaniforme-genetique-archeologieSuivez La Dent Bleue sur :

A mathematician sets out to participate in the study of evolution... and ends up engaging in some fascinating research about social cooperation and the queerness of evolution!    In this episode, Sara Jolena sits down with her old college friend Ben Allen, a mathematician whose work models how cooperation evolves — from iron-sharing bacteria to communal-nesting birds. They consider what this research might illuminate about cooperation in human communities. They then turn towards some of Ben's current research on queerness in evolution. Same-sex behavior has now been documented in more than 1,500 species... and it just keeps getting more interesting! Key Topics & Timestamps00:00 — Intro: welcome to ReMembering and ReEnchanting01:05 — Meet Ben Allen: mathematician, old friend, and a researcher on evolution 02:56 — From pure math to evolutionary biology: how Ben's path unfolded04:26 — Why organisms cooperate — and why "survival of the fittest" is an incomplete story06:27 — The bacteria that share iron with their neighbors08:18 — Modeling evolution mathematically: networks, neighbors, and cooperation09:13 — From microbes to mammals: what changes (and what doesn't) when culture enters the picture11:03 — Local connection as a strategy for large-scale engagement (including activism)12:52 — Other paths to cooperation: kin selection, reciprocity, and reputation14:26 — What evolution actually means: reproduction, inheritance, and mutation16:53 — A parallel to religious traditions: continuity and change in tension17:42 — What "reproduction" really means across the tree of life (sexual, asexual, horizontal gene transfer)19:37 — What biologists actually mean by "male" and "female" — and why the definition breaks down23:04 — Evolution "finds a way": clonal fish, sex-changing clownfish, and the limits of a human template25:45 — Sex beyond reproduction: play, pleasure, and social bonding across species26:43 — The 2019 paper reframing same-sex behavior in animals31:28 — Ben's current research: could early marine life not even "see" sex at all?33:15 — Deep-sea squid, imperfect filtering, and why indiscriminate mating can be an evolutionary advantage36:37 — Two evolutionary strategies: cost of mating vs. population density38:36 — Connection, yearning, and sociability across species41:10 — Individual variation: why generalizing about any species misses the truth42:16 — "A very queer evolutionary story"43:20 — Darwin's Victorian assumptions that we are still unlearning44:40 — The perspective of the scientist shifts the questions and analysis that the scientist does. We need many, many different perspectives for these big complex questions! 45:31 — Situated knowledge, Donna Haraway, and the case for multiple vantage points46:23 — Closing reflections and thanksBen Allen is a Professor of Mathematics at Emmanuel College, Boston, MA. Their research focuses on mathematical modeling of evolution—in particular the evolution of social (other-directed) behavior. Their work has appeared in Nature, Proceedings of the National Academy of Sciences, and The Atlantic. Send us a messageSupport the showLearn more about Sara Jolena Wolcott and Sequoia SamanvayaMusic Title: Both of UsMusic by: madiRFAN Don't forget to "like" and share this episode! 

In this episode, we will discuss multiverse analysis–what it is, why we use it, and how we should use it. We also discuss many analyst projects, and Daniel's new preprint on multiverse analysis.    Shownotes Auspurg, K. (2025). Robustness is better assessed with a few thoughtful models than with billions of regressions. Proceedings of the National Academy of Sciences, 122(43), e2521917122. Chamberlin, T. C. (1890). The method of multiple working hypotheses. Science, (366), 92–96. Dochtermann, N. A., & Jenkins, S. H. (2011). Developing multiple hypotheses in behavioral ecology. Behavioral Ecology and Sociobiology, 65(1), 37–45. Dreber, A., & Johannesson, M. (2025). The credibility gap: Evaluating and improving empirical research in the social sciences. Routledge. Gelman, A., & Loken, E. (2013). The garden of forking paths: Why multiple comparisons can be a problem, even when there is no “fishing expedition” or “p-hacking” and the research hypothesis was posited ahead of time. Department of Statistics, Columbia University, 348(1-17), 3. Knief, U., & Forstmeier, W. (2025). Are our 95% CIs only worth 45% confidence? bioRxiv, 2025-08. Lakens, D., Rasti, S., & Tunç, M. N. (2026). There is only one correct analysis. (Preprint) Platt, J. R. (1964). Strong Inference: Certain systematic methods of scientific thinking may produce much more rapid progress than others. Science, 146(3642), 347–353. Simonsohn, U., Simmons, J. P., & Nelson, L. D. (2020). Specification curve analysis. Nature Human Behaviour, 4(11), 1208–1214. Steegen, S., Tuerlinckx, F., Gelman, A., & Vanpaemel, W. (2016). Increasing transparency through a multiverse analysis. Perspectives on Psychological Science, 11(5), 702–712. Wimsatt, W. C. (2007). Re-engineering philosophy for limited beings: Piecewise approximations to reality. Harvard University Press.  

The Lindsay Clancy murder trial is now in recess until Friday morning, but not before jurors heard from two more people who were on scene in the earliest, most chaotic minutes after Clancy's three children were found. Clancy, 34, of Duxbury, Massachusetts, is accused of strangling 5-year-old Cora, 3-year-old Dawson, and 7-month-old Callan with exercise resistance bands inside the family's Summer Street home on January 24, 2023. She faces three counts of murder and three counts of strangulation, has pleaded not guilty, and her defense, led by attorney Kevin Reddington, argues she was in the grip of severe postpartum psychosis and psychiatric overmedication.Duxbury firefighter-paramedic Daniel Dougherty testified about fitting Clancy with a stabilizing neck collar and treating her en route in the ambulance. Cross-examination pushed into whether cold exposure could have restricted her blood flow — a detail that matters more than it sounds, given what the defense is trying to establish about her condition that day. Duxbury Police Officer Vincent Cahill then walked jurors through what he found at the scene, the equipment he brought in trying to help, and his role assisting with CPR on Cora — testimony that doesn't get easier to deliver no matter how many times an officer has had to give it.Prosecutors maintain Clancy understood what she was doing regardless of her mental state. She allegedly attempted suicide afterward by jumping from a second-story window and remains paralyzed from the waist down. Her husband, Patrick Clancy, was out running errands at the time and has since relocated to Manhattan. Proceedings resume Friday morning in Plymouth Superior Court and are expected to continue for several more weeks.Join Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1Instagram https://www.instagram.com/hiddenkillerspod/Facebook https://www.facebook.com/hiddenkillerspod/Tik-Tok https://www.tiktok.com/@hiddenkillerspodX Twitter https://x.com/TrueCrimePodThis publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.#LindsayClancy #DuxburyTragedy #PostpartumPsychosis #TrueCrime #PlymouthCounty #CoraDawsonCallan #InsanityDefense #KevinReddington #TrueCrimeToday #Breaking

In the second episode of this series of the Pump Court Family Law Podcast, Rebekah Batt is joined by Jennifer Pollock and Catriona Ellis, of Irwin Mitchell, and Elena Johnson of Pump Court Chambers to discuss neurodiversity in private children proceedings. This episode was inspired by Catriona and Jennifer's article linked here and includes discussion around helpful evidence for the court and authors of section 7 reports, how to deal with cases where there is no diagnosis, when to start thinking about the issue and methods to assist parties with neurodiversity, as well as neurodivergent children. Other resources referred to or which may be useful are: Family Justice Council Guidance on Neurodiversity in the Family Justice System, January 2025 – linked here;Sunflower Lanyard scheme in HMCTS – details linked here; (not referenced but useful) Practice Guidance on the use of Intermediaries, Lay Advocates and Cognitive Assessments in the Family court from January 2025 (updated November 2025) – linked here. Hosted on Acast. See acast.com/privacy for more information.

Featuring perspectives from Ms Kelly Fischer, Dr Marissa Marti-Smith, Dr Rita Nanda and Dr Ruth M O'Regan, moderated by Dr Nanda, including the following topics: Introduction (00:00) Advent of CDK4/6 Inhibitors in HR-Positive Breast Cancer (BC) (1:24) Risk Assessment for Patients with HR-Positive, HER2-Negative Localized BC (2:52) Adjuvant CDK4/6 Inhibitor Therapy (17:14) Practical Considerations with CDK4/6 Inhibitors (29:57) Monitoring and Management of Cytopenias (42:02) CDK4/6 Inhibitors in HR-Positive Metastatic BC (49:32) Management of Gastrointestinal Adverse Events (1:03:47) CDK4/6 Inhibitors in Unique Populations (1:10:41) Rarer CDK4/6 Inhibitor-Associated Toxicities (1:19:48) CME information and select publications

See omnystudio.com/listener for privacy information.

"You have to figure out how to make self-care a priority because you know the body does not sit still... Your mindset will allow you to move forward, or it will take you backwards." —Dr. Mitra Ray Stanford-trained biologist Dr. Mitra Ray spent three decades building a career in women's longevity, but the habits she taught everyone else became something she never expected: the infrastructure that kept her upright after her husband, Doug, died suddenly in a paragliding accident in October 2023. In this conversation with host Justine Reichman, Dr. Ray traces her path from NIH- and Alzheimer's-funded cancer research to walking away from the lab, building a word-of-mouth wellness brand that sold 2 million copies with zero advertising, and eventually testing her own biological age during the hardest year of her life — and watching it go backward. This episode is for anyone navigating midlife, grief, perimenopause, or the quiet realization that the wellness habits they've dismissed as trendy might be the thing holding them together. Dr. Ray and Justine talk candidly about cold plunging, sobriety, plant-based nutrition, sleep science, and the gut-microbiome research behind cravings — grounding every claim in the biology, not the buzzwords. Key takeaways: Dr. Ray's biological age measurably reversed during the year she grieved her husband, evidence that consistent habits can outperform circumstance. Comparing your current body to a memory of your 25-year-old self is biologically counterproductive — memories change every time you access them, and the comparison itself triggers cortisol and inflammation. Cold plunging activates the anterior mid-cingulate cortex, the brain region tied to willpower and will to live, which Dr. Ray leaned on deliberately after losing Doug. Food cravings are largely dictated by gut bacteria, not willpower — feeding plant-based bacteria gradually shifts what your body craves. "Superagers" in their 80s are still generating new neurons, making neurogenesis — not a return to a younger self — the more useful benchmark for healthy aging. Grief lives in the body: cortisol, thyroid, and hormone levels shift during loss, and naming that process without judgment is part of recovering from it. Listen to the full conversation and subscribe to Essential Ingredients for more real conversations at the intersection of food, purpose, and building a better future: https://tinyurl.com/Essential-Ingredients-Podcast  Meet Dr. Ray:  Living a long, healthy life is not as complicated as the wellness industry would have you believe. Dr. Mitra Ray has spent more than 30 years helping people understand this, and more importantly, live it. Her path into health was shaped by both rigorous science and lived experience. She completed her undergraduate degree at Cornell University and earned her PhD from Stanford Medical School, where her research was funded by multiple NIH grants and recognized with the Young Investigator Award from the Federation of American Societies in Experimental Biology. Her work has been published in Science, Proceedings of the National Academy of Sciences, and the Journal of Cell Biology: journals that do not publish ideas lightly. But credentials alone do not explain why audiences across four continents keep coming back to hear her speak, or why her books and lectures on health, beauty, brain function, and longevity have resonated as widely as they have. The reason is simpler: she translates what the science actually says into something you can do and sustain. Her focus has always been whole plant foods, an active body, and a clear mind. These three things, she has come to understand, are not a wellness trend. They are the foundation. Everything downstream of that foundation- how you look, how you feel, how you age- follows. The Elder's Evolution, her Substack publication, is where she writes about what it means to age well, with full attention paid to both the biology and the deeper questions that biology alone cannot answer. Website LinkedIn Instagram Substack Connect with NextGen Purpose: Website Facebook Instagram LinkedIn YouTube Podcast Chapters: 01:31 Meet Dr. Mitra Ray: From Stanford Lab to Wellness Pioneer 05:41 Leaving Science: How Her Family and Peers Reacted 09:03 Why Doctors Still Ignore Whole-Food Nutrition 16:52 Stop Comparing Yourself to a Body That No Longer Exists 19:45 Building a 2-Million-Copy Word-of-Mouth Wellness Brand 23:03 After Doug's Death: The Habits That Became Her Infrastructure 32:36 Cold Plunging, the AMC, and Rebuilding Willpower After Loss 51:02 The Real Benchmark for Aging Isn't Your 25-Year-Old Self 54:34 Cravings Aren't Willpower — It's Your Gut Microbiome 

Featuring perspectives from Dr Tanios Bekaii-Saab, Dr Stacey A Cohen and Dr Arvind Dasari, moderated by Dr Bekaii-Saab, including the following topics: Introduction (0:00) Current and Future Role of Immune Checkpoint Inhibition in the Management of Microsatellite Instability-High/Mismatch Repair Deficient Localized and Locally Advanced Colorectal Cancer (CRC) — Dr Cohen (1:45) Clinical Relevance and Practical Utilization of Molecular Residual Disease Analysis in CRC — Dr Dasari (34:08) Recent Advances in Metastatic CRC: Optimizing Immunotherapy and Other Approaches — Dr Bekaii-Saab (1:00:42) CME information and select publications

For most of the last century, gardeners were taught to cultivate their soil after every rain to conserve moisture, to think of plant roots as lone competitors, and to treat "plant communication" as science fiction. All of that was built on the best evidence available at the time, and all of it has been revised, in some cases more than once, as better tools let researchers see what earlier generations simply could not. In this episode, we walk through four real case studies of plant science changing its mind. Along the way, we talk about how the scientific method works, why one of my favorite phrases, "we don't know what we don't know," is not a discouraging idea but an exciting one, and what all of this means for the choices you make in your own garden each season, now and into the future. Let's dig in! References and Resources: Chalker-Scott, L., and C.H. Daniels. (2016). "Scientific Literacy for the Citizen Scientist." WSU Extension Manual EM100E. https://wpcdn.web.wsu.edu/extension/uploads/sites/30/2024/07/Scientific-Literacy-for-the-Citizen-Scientist.pdf Chalker-Scott, L. (2021, revised). "Dust Mulch Efficacy in Gardens and Landscapes." WSU Extension Fact Sheet FS167E. https://wpcdn.web.wsu.edu/wp-ecommerce/uploads/sites/2/product-3540-sku-FS167E.pdf Chalker-Scott, L. (2017). "A Gardener's Primer to Mycorrhizae: Understanding How They Work and Learning How to Protect Them." WSU Extension Fact Sheet FS269E. https://wpcdn.web.wsu.edu/wp-ecommerce/uploads/sites/2/product-3286-sku-FS269E.pdf Chalker-Scott, L. (2023). "Gardening with Companion Plants." WSU Extension Publication EM128E. https://pubs.extension.wsu.edu/product/gardening-with-companion-plants-home-garden-series/ Oklahoma State University Extension. "Mycorrhizal Fungi." Fact Sheet. https://extension.okstate.edu/fact-sheets/mycorrhizal-fungi Pacific Horticulture Society. "Mycorrhizal Fungi, Nature's Key to Plant Survival and Success." https://pacifichorticulture.org/articles/mycorrhizal-fungi-natures-key-to-plant-survival-and-success/ Cao, D., Chabikwa, T., Barbier, F., Dun, E.A., Fichtner, F., Dong, L., Kerr, S.C., & Beveridge, C.A. (2023). "Auxin-independent effects of apical dominance induce changes in phytohormones correlated with bud outgrowth." Plant Physiology, 192(2), 1420–1434. https://doi.org/10.1093/plphys/kiad034 Mason, M.G., Ross, J.J., Babst, B.A., Wienclaw, B.N., & Beveridge, C.A. (2014). "Sugar demand, not auxin, is the initial regulator of apical dominance." Proceedings of the National Academy of Sciences, 111(16), 6092–6097. https://www.pnas.org/doi/10.1073/pnas.1322045111 Barbier, F.F., Dun, E.A., & Beveridge, C.A. (2017). "A Growing Stem Inhibits Bud Outgrowth — The Overlooked Theory of Apical Dominance." Frontiers in Plant Science, 8:1874. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671643/ "Lessons from a century of apical dominance research." (2023). Journal of Experimental Botany. https://pmc.ncbi.nlm.nih.gov/articles/PMC10400159/ Simard, S.W., Perry, D.A., Jones, M.D., Myrold, D.D., Durall, D.M., & Molina, R. (1997). "Net transfer of carbon between ectomycorrhizal tree species in the field." Nature, 388, 579–582. https://www.nature.com/articles/41557 "Belowground carbon transfer across mycorrhizal networks among trees: Facts, not fantasy." (2023). Review discussing the scope and limits of current evidence for mycorrhizal carbon transfer. https://pmc.ncbi.nlm.nih.gov/articles/PMC10751480/ Baldwin, I.T., & Schultz, J.C. (1983). "Rapid Changes in Tree Leaf Chemistry Induced by Damage: Evidence for Communication Between Plants." Science, 221(4607), 277–279. https://www.science.org/doi/10.1126/science.221.4607.277 Heil, M. (2014). "Herbivore-induced plant volatiles: targets, perception and unanswered questions." New Phytologist, 204(2), 297–306. https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.12977 Just Grow Something: https://justgrowsomething.com Gardening Courses: https://justgrowsomething.com/courses Just Grow Something Merch and Downloads: https://justgrowsomething.com/shop Just Grow Something Gardening Friends Facebook Group: https://www.facebook.com/share/g/18YgHveF5P/ Check out how you can become a patron on Patreon: https://www.patreon.com/JustGrowSomething Feed my coffee habit: https://buymeacoffee.com/justgrowsomething Amazon storefront: https://www.amazon.com/shop/justgrowsomething Get 10% off and FREE shipping on my favorite raised planters at Planter Box Direct using code JUSTGROW10: https://planterboxdirect.com/?ref=593 Save on your Aquatru water system at Aquatru.com using code GROW. https://aquatru.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

For part of its history, Nassau was a notorious hotbed of pirate activity. And it was home to a maritime criminal network known as the Flying Gang. Research: "Bahamas, the." The Columbia Electronic Encyclopedia™, The Columbia UP, 2025. Gale OneFile: High School Edition, link.gale.com/apps/doc/A69385873/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=7f7affa4. Accessed 8 July 2026. Ahrens, Wolfgang P. “Naming the Bahamas Islands: History and Folk Etymology.” Names and Their Environment. Proceedings of the 25th International Congress of Onomastic Sciences, Glasgow, 25-29. August 2014. Vol. 1. Keynote Lectures. Toponomastics I. Carole Hough and Daria Izdebska (eds). First published 2016 by University of Glasgow under Creative Commons license. https://www.gla.ac.uk/media/Media_576595_smxx.pdf Butler, Lindley S. “North Carolina 1718: The Year of the Pirates.” The North Carolina Historical Review, Vol. 95, No. 2 (APRIL 2018). Via JSTOR. https://www.jstor.org/stable/45184933 Cartwright, Mark. "Benjamin Hornigold." World History Encyclopedia, 09 Sep 2021, https://www.worldhistory.org/Benjamin_Hornigold/. Craton, Michael. “A History of the Bahamas.” London. Collins. 1962. Enthoven, Victor. “‘That Abominable Nest of Pirates’: St. Eustatius and the North Americans, 1680—1780. Early American Studies , Spring 2012, Vol. 10, No. 2. Via JSTOR. https://www.jstor.org/stable/23547669 Fox, E.T. “Jacobitism and the ‘Golden Age’ of Piracy, 1715-1725.” International Journal of Maritime History, XXII, No. 2 (December 2010), 277-303. Hahn, Steven C. “The Atlantic Odyssey of Richard Tookerman.” Early American Studies, Summer 2017, Vol. 15, No. 3 (Summer 2017). Via JSTOR. https://www.jstor.org/stable/10.2307/90011103 Keegan, William F. “The Native Peoples of Turks and Caicos.” Florida Museum. https://www.floridamuseum.ufl.edu/caribarch/education/tc-peoples/ Kinsella, Pat. “The real pirates of the Caribbean: your guide to Nassau's pirate republic.” History Extra. 1/20/2022. https://www.historyextra.com/period/stuart/nassau-pirate-republic-flying-gang-real-pirates-caribbean/ Lane, Kris. “Pirate Networks in the Caribbean.” From Empires of the Sea: Maritime Power Networks in World History. Brill. 2020. Via JSTOR. https://www.jstor.org/stable/10.1163/j.ctv2gjx041.18 Leeson, Peter T. “An‐arrgh‐chy: The Law and Economics of Pirate Organization.” Journal of Political Economy , Vol. 115, No. 6 (December 2007). Via JSTOR. https://www.jstor.org/stable/10.1086/526403 Moore, David D. “Captain Edward Thatch: A Brief Analysis of the Primary Source Documents Concerning the Notorious Blackbeard.” The North Carolina Historical Review, Vol. 95, No. 2 (APRIL 2018). Via JSTOR. https://www.jstor.org/stable/45184934 Queen Anne’s Revenge Project. “Did You Know Blackbeard’s Mentor Was a Pirate Hunter?” 3/8/2018. https://www.qaronline.org/blog/2018-03-08/did-you-know-blackbeards-mentor-was-pirate-hunter Rediker, Marcus. “‘Under the Banner of King Death’: The Social World of Anglo-American Pirates, 1716.” The William and Mary Quarterly , Apr., 1981. https://www.jstor.org/stable/1918775 Saunders, Gail. "Rogers, Woodes (c. 1679–1732), privateer and colonial governor." Oxford Dictionary of National Biography. January 03, 2008. Oxford University Press. Date of access 9 Jul. 2026, https://www.oxforddnb.com/view/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-24006 Sheposh, Richard. “Republic of Pirates.” EBSCO. 2023. https://www.ebsco.com/research-starters/history/republic-pirates Wilson, David. “The 1715 Plate Fleet and the Rise of the Pirates.” History Today. 6/30/2015. https://www.historytoday.com/1715-plate-fleet-and-rise-pirates Woodard, Colin. “The republic of pirates : being the true and surprising story of the Caribbean pirates and the man who brought them down.” New York, NY : Mariner Books. 2007. See omnystudio.com/listener for privacy information.

Featuring perspectives from Dr Sara A Hurvitz, Dr Erica Mayer, Dr Joyce O'Shaughnessy, Dr Sara M Tolaney and Dr Nicholas Turner, moderated by Dr Tolaney, including the following topics: Introduction (0:00) Current and Future Roles of Agents Targeting the PI3K/AKT/mTOR Pathway and Oral Selective Estrogen Receptor Degraders (SERDs) in First-Line Therapy for HR-Positive, HER2-Negative Metastatic Breast Cancer (mBC) — Dr Turner (2:35) Role of Oral SERD Monotherapy in the Treatment of Progressive HR-Positive, HER2-Negative mBC — Dr O'Shaughnessy (25:23) Potential Use of Oral SERD-Containing Combination Regimens in Managing Progressive HR-Positive, HER2-Negative mBC — Dr Mayer (46:29) Clinical Utility of Agents Targeting the PI3K/AKT/mTOR Pathway for Patients with Progressive HR-Positive, HER2-Negative mBC — Dr Hurvitz (1:07:06) Potential Use of Oral SERDs for HR-Positive, HER2-Negative Localized Breast Cancer — Dr Tolaney (1:38:17) CME information and select publications

President Cyril Ramaphosa has succeeded in his urgent application to interdict Parliament's Section 89 Impeachment inquiry. The Western Cape High Court has ordered that the impeachment committee's proceedings be halted pending the outcome of the President's review application challenging the Section 89 Independent Panel report, which found that he may have a case to answer, in the theft of 580-thousand US dollars on his Phala Phala farm. in 2020. The ruling has temporarily halted the work of the committee. Judge Andre Le Grange delivered the judgment...

Skip to the updates: (50:00)On January 24, 2023, Patrick Clancy left his family's home in Duxbury, Massachusetts, to run a few errands, expecting to return less than an hour later. Instead, he came home to an unimaginable tragedy. The house was eerily silent, and outside he found his wife, Lindsay Clancy, seriously injured. She told him the children were in the basement.Patrick rushed downstairs, where he discovered his three children, 5-year-old Cora, 3-year-old Dawson, and 8-month-old Callan, had been strangled with exercise bands. Cora and Dawson died that night, while Callan succumbed to his injuries several days later. Lindsay survived after jumping from a second-story window and was later charged with the murders of her children. Her defense argues that she was suffering from postpartum psychosis and should not be held criminally responsible. Her trial is now underway, with her husband expected to testify on her behalf.Read our blog for this case - https://truecrimesocietyblog.com/2023/02/27/lindsay-clancy-strangled-her-three-children-with-exercise-bands/This episode was originally first released in 2023. We are re-releasing it now to coincide with the start of Lindsay Clancy's trial. Proceedings in the trial began on July 20 and are expected to run for up to 8 weeks. If you are familiar with the case and would like to proceed straight to the updates that have happened since 2023, please check the timestamp.Join us on Patreon for weekly exclusive episodes and all episodes are ad-free - Patreon.com/truecrimesociety Check out our Instagram for the latest crime news - Instagram.com/truecrimesociety Follow our Facebook page for breaking news - Facebook.com/truecrimesociety This episode is sponsored by:  Jones Road Beauty - Modern-day makeup that's clean, strategic, and multifunctional for effortless routines. For a limited time, our listeners are getting a FREE full size Mascara on their first purchase. Head to JonesRoadBeauty.com and use code TCS at checkout. Lola Blankets - Lola is the world's #1 blanket, crafted with ultra-soft, luxury faux fur and a signature 4-way stretch that sets it apart. For a limited time, our listeners can get 40% OFF select Lola Blankets products with code TCS at checkout. Just head to LolaBlankets.com and use code TCS.

Featuring perspectives from Dr Bradley J Monk, Dr David M O'Malley, Ms Kathryn M Schlenker and Ms Jaclyn Shaver, moderated by Dr O'Malley, including the following topics: Introduction (00:00) Overview of Ovarian Cancer (OC) (2:12) Role of PARP Inhibitors in Advanced OC (4:56) Current and Potential Future Role of Mirvetuximab Soravtansine in OC (28:45) Role of Relacorilant in Advanced OC (57:08) Utility of Immune Checkpoint Inhibition in Advanced OC (1:14:12) NCPD information and select publications

Featuring perspectives from Dr Melissa Alsina, Dr Hans Lee, Dr Sagar Lonial and Dr Paul G Richardson, moderated by Dr Lonial, including the following topics: Introduction (0:00) Integrating Bispecific Antibodies into the Management of Relapsed/Refractory (R/R) Multiple Myeloma (MM) — Dr Lee (1:45) Current Utility of Antibody-Drug Conjugates for MM — Dr Lonial (33:55) Potential Role of Cereblon E3 Ligase Modulators in Therapy for MM — Dr Richardson (59:42) Chimeric Antigen Receptor T-Cell Therapy for R/R MM — Dr Alsina (1:30:24) CME information and select publications

Featuring perspectives from Dr Sarah B Goldberg, Dr Jonathan Goldman, Dr Joel W Neal, Dr Antonio Passaro and Dr Jacob Sands, moderated by Dr Sands, including the following topics: Introduction (00:00) Evolving First-Line Treatment for Metastatic EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC) — Prof Passaro (2:27) EGFR-Targeted Therapeutic Strategies for Relapsed EGFR-Mutant NSCLC — Dr Neal (36:08) Utility of TROP2-Targeted Antibody-Drug Conjugates in the Management of EGFR-Mutant NSCLC — Dr Sands (56:16) Emerging Role of Bispecific Antibody-Based Approaches for EGFR-Mutated NSCLC — Dr Goldman (1:19:08) Tolerability Considerations with the Use of Available and Emerging Therapies for EGFR-Mutated NSCLC — Dr Goldberg (1:38:46) CME information and select publications

En este episodio nos adentramos en una de las estructuras más fascinantes y peor simplificadas del sistema nervioso: el tálamo. Durante años se nos ha enseñado como una gran “estación de relevo sensitiva”, pero esa metáfora se queda corta. El tálamo no solo transmite información hacia la corteza: la filtra, la organiza, la modula y participa en el estado funcional en el que esa información llega al cerebro consciente. A lo largo del episodio recorremos su historia, su lugar dentro del diencéfalo, sus principales núcleos y su papel en sensibilidad, visión, audición, movimiento, memoria, atención, cognición y conciencia. Pero el episodio no se queda en la anatomía clásica. Entramos también en la neurofisiología moderna del tálamo: entradas drivers y modulators, núcleos de primer orden y de orden superior, bucles cortico-tálamo-corticales, modos de disparo tónico y en ráfaga. Finalmente, aterrizamos todo en clínica: ictus talámicos, dolor central, afasia talámica, negligencia, alteraciones cognitivas, trastornos del movimiento, arteria de Percheron, mesocircuito de Schiff y la idea central del episodio: el tálamo enferma como nodo, no como simple estación. Referencias del episodio: 1. Atallah, O., Almealawy, Y. F., Alabide, A. S., Farooq, M., Sanker, V., Alrubaye, S. N., Darwazeh, R., Awuah, W. A., Abdul-Rahman, T., Muthana, A., Saleh, A., Wellington, J., & Badary, A. (2024). Navigating the clinical landscape of artery of Percheron infarction: A systematic review. eNeurologicalSci, 37, 100521. https://doi.org/10.1016/j.ensci.2024.100521 (https://pubmed.ncbi.nlm.nih.gov/39257866/). 2. Biesbroek, J. M., Verhagen, M. G., van der Stigchel, S., & Biessels, G. J. (2024). When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(3), 2209–2222. https://doi.org/10.1002/alz.13563 (https://pmc.ncbi.nlm.nih.gov/articles/PMC10984498/). 3. Bolkan, S. S., Stujenske, J. M., Parnaudeau, S., Spellman, T. J., Rauffenbart, C., Abbas, A. I., Harris, A. Z., Gordon, J. A., & Kellendonk, C. (2017). Thalamic projections sustain prefrontal activity during working memory maintenance. Nature neuroscience, 20(7), 987–996. https://doi.org/10.1038/nn.4568 (https://pubmed.ncbi.nlm.nih.gov/28481349/). 4. Cacciatore, M., Magnani, F. G., Barbadoro, F., Ippoliti, C., Stanziano, M., Clementi, L., Nigri, A., Nanetti, L., Marino, S., La Porta, F., Lucca, L. F., Prada, F., & Leonardi, M. (2025). Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness. Frontiers in neurology, 16, 1509668. https://doi.org/10.3389/fneur.2025.1509668 (https://pmc.ncbi.nlm.nih.gov/articles/PMC12241866/). 5. Cao, T., He, S., Wang, L., Chai, X., He, Q., Liu, D., Wang, D., Wang, N., He, J., Wang, S., Yang, Y., Zhao, J., & Tan, H. (2024). Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review. CNS neuroscience & therapeutics, 30(6), e14559. https://doi.org/10.1111/cns.14559 (https://pubmed.ncbi.nlm.nih.gov/38115730/). 6. Fritsch, M., Rangus, I., & Nolte, C. H. (2022). Thalamic Aphasia: a Review. Current neurology and neuroscience reports, 22(12), 855–865. https://doi.org/10.1007/s11910-022-01242-2 (https://pmc.ncbi.nlm.nih.gov/articles/PMC9750901/). 7. Gupta, N., & Pandey, S. (2018). Post-Thalamic Stroke Movement Disorders: A Systematic Review. European neurology, 79(5-6), 303–314. https://doi.org/10.1159/000490070 (https://pubmed.ncbi.nlm.nih.gov/29870983/). 8. Marcuse, L. V., Langan, M., Hof, P. R., Panov, F., Saez, I., Jimenez-Shahed, J., Figee, M., Mayberg, H., Yoo, J. Y., Ghatan, S., Balchandani, P., & Fields, M. C. (2025). The thalamus: Structure, function, and neurotherapeutics. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 22(2), e00550. https://doi.org/10.1016/j.neurot.2025.e00550 (https://pubmed.ncbi.nlm.nih.gov/39956708/). 9. Mitchell A. S. (2015). The mediodorsal thalamus as a higher order thalamic relay nucleus important for learning and decision-making. Neuroscience and biobehavioral reviews, 54, 76–88. https://doi.org/10.1016/j.neubiorev.2015.03.001 (http://pubmed.ncbi.nlm.nih.gov/25757689/). 10. Schiff N. D. (2010). Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends in neurosciences, 33(1), 1–9. https://doi.org/10.1016/j.tins.2009.11.002 (https://pubmed.ncbi.nlm.nih.gov/19954851/). 11. Schmahmann J. D. (2003). Vascular syndromes of the thalamus. Stroke, 34(9), 2264–2278. https://doi.org/10.1161/01.STR.0000087786.38997.9E (https://pubmed.ncbi.nlm.nih.gov/12933968/). 12. Schmitt, L. I., Wimmer, R. D., Nakajima, M., Happ, M., Mofakham, S., & Halassa, M. M. (2017). Thalamic amplification of cortical connectivity sustains attentional control. Nature, 545(7653), 219–223. https://doi.org/10.1038/nature22073 (https://pubmed.ncbi.nlm.nih.gov/28467827/). 13. Sherman, S. M., & Guillery, R. W. (1998). On the actions that one nerve cell can have on another: distinguishing "drivers" from "modulators". Proceedings of the National Academy of Sciences of the United States of America, 95(12), 7121–7126. https://doi.org/10.1073/pnas.95.12.7121 (https://pubmed.ncbi.nlm.nih.gov/9618549/). 14. Sherman S. M. (2016). Thalamus plays a central role in ongoing cortical functioning. Nature neuroscience, 19(4), 533–541. https://doi.org/10.1038/nn.4269 (https://pubmed.ncbi.nlm.nih.gov/27021938/). 15. Steriade M. (2005). Sleep, epilepsy and thalamic reticular inhibitory neurons. Trends in neurosciences, 28(6), 317–324. https://doi.org/10.1016/j.tins.2005.03.007 (http://pubmed.ncbi.nlm.nih.gov/15927688/). 16. Whyte, C. J., Redinbaugh, M. J., Shine, J. M., & Saalmann, Y. B. (2024). Thalamic contributions to the state and contents of consciousness. Neuron, 112(10), 1611–1625. https://doi.org/10.1016/j.neuron.2024.04.019 (https://pubmed.ncbi.nlm.nih.gov/38754373/).

Send us Fan MailWe start with a simple mystery: how the same person can make a proud plan at night and break it in the morning, even while still believing the plan is good. We connect akrasia, free will, and moral responsibility to transaction costs, treating self-control as a contracting problem between competing versions of ourselves. • Jordan I and Jordan II as a model of divided preferences over time • Hard determinism, libertarian free will, and compatibilism as the main philosophical map • Responsibility and punishment as social conventions that reduce coordination costs • Aristotle on voluntary intoxication and why blame can attach upstream • Akrasia defined as wanting to want the right thing • Plato's knowledge-based denial of akrasia versus Aristotle's acceptance of weakness of will • Paul and Augustine on the internal conflict of the will • Time-inconsistent preferences and hyperbolic discounting as a behavioral explanation • Commitment devices as credible commitments and transaction cost engineering • Odysseus and the sirens as the classic precommitment story • Listener letter on military punctuality as costly signaling and institutional discipline • Listener letter on recycling labels as regulation creating new transaction costs Links and Sources1. Ainslie, G. (1992). Picoeconomics: The strategic interaction of successive motivational states within the person. Cambridge University Press.  Link: Cambridge University Press — Picoeconomics 2. Aristotle. (1999). Nicomachean ethics (W. D. Ross, Trans.). Batoche Books. (Original work published ca. 350 B.C.E.)  Passage: Book VII (on incontinence/akrasia). Link: Nicomachean Ethics, trans. W. D. Ross (free PDF)3. Augustine. (1838). The confessions of Saint Augustine (E. B. Pusey, Trans.). John Henry Parker. (Original work written ca. 397–400 C.E.)  Passage: Book VIII, Chapters 8–9 (§§20–21). Link: Confessions, Book VIII, Pusey translation (free full text)4. Davidson, D. (1970). How is weakness of the will possible? In J. Feinberg (Ed.), Moral concepts (pp. 93–113). Oxford University Press. Link: Oxford Academic — "How Is Weakness of the Will Possible?" (in Essays on Actions and Events) (gated — subscription/institutional access)5. Dennett, D. C. (1984). Elbow room: The varieties of free will worth wanting. MIT Press. Link: MIT Press — Elbow Room (gated — purchase; excerpts free)6. Dennett, D. C. (2003). Freedom evolves. Viking.  Link: Internet Archive — Freedom Evolves (gated — free with Internet Archive lending account)7. Hume, D. (1999). An enquiry concerning human understanding (T. L. Beauchamp, Ed.). Oxford University Press. (Original work published 1748) Passage: Section VIII, "Of Liberty and Necessity." Link: Hume Texts Online — Section 8 (free full text)8. King James Bible. (2017). King James Bible Online. https://www.kingjamesbibleonline.org/ (Original work published 1769) Passage: Romans 7. Link: Romans, Chapter 7 (KJV) (free full text)9. Plato. (1967). Protagoras (W. R. M. Lamb, Trans.). Harvard University Press. (Original work published ca. 380 B.C.E.)  Link: Perseus Digital Library — Protagoras (Lamb trans.) (free full text)10. Schelling, T. C. (1984). The intimate contest for self-command. In Choice and consequence: Perspectives of an errant economist. Harvard University Press.  Link: National Affairs — "The Intimate Contest for Self-Command" (original 1980 essay, free full text) · Harvard University Press — Choice and Consequence (book page, gated)11. Strawson, P. F. (1962). Freedom and resentment. Proceedings of the British Academy, 48, 1–25. Link: The British Academy — Freedom and Resentment (official publisher page, may be gated)12. Vaihinger, H. (1925). The philosophy of 'as if': A system of the theoretical, practical and religious fictions of mankind (C. K. Ogden, Trans.). Harcourt, Brace. (Original work published 1911)Link: Internet Archive — The Philosophy of 'As If' (free full text)Book-o-da-Week:  Emily Wilson's translation of Homer's THE ODYSSEY, 2018, WW Norton. If you have questions or comments, or want to suggest a future topic, email the show at taitc.email@gmail.com !You can follow Mike Munger on Twitter at @mungowitz 

In 2007, two Harvard researchers added a splash of balsamic vinegar to beer.  When drinkers knew the beer contained vinegar, they hated it.  But when the researchers told them “this is our MIT brew," the majority loved it.  The study reveals the secrets behind marketing.  On today's episode of Nudge with award-winning science writer David Robson, we explain how good marketing can shape our perception.  Link to the bonus episode: ⁠https://nudge.kit.com/86d3e39845⁠  Become an FSB member: https://get.fsb.org.uk/nudge/ Read the Expectation Effect: https://amzn.to/4dvkb3s  David's website: https://davidrobson.me/  David's Substack: https://davidarobson.substack.com/  ---  Today's sources:  Amar, M., Ariely, D., Bar-Hillel, M., Carmon, Z., & Ofir, C. (2011). Brand names act like marketing placebos. Hebrew University of Jerusalem. Clark, A. (2016). Surfing uncertainty: Prediction, action, and the embodied mind. Oxford University Press. Crum, A. J., & Langer, E. J. (2007). Mind-set matters: Exercise and the placebo effect. Psychological Science, 18(2), 165–171. Faasse, K., Martin, L.R., Grey, A., Gamble, G., and Petrie, K.J. (2016). Impact of brand or generic labeling on medication effectiveness and side effects. Health Psychology, 35(2), 187. Grabenhorst, F., Rolls, E. T., & Bilderbeck, A. (2008). How cognition modulates affective responses to taste and flavor: Top-down influences on the orbitofrontal and pregenual cingulate cortices. Cerebral Cortex, 18(7), 1549–1559. Lee, L., Frederick, S., & Ariely, D. (2006). Try it, you'll like it: The influence of expectation, consumption, and revelation on preferences for beer. Psychological Science, 17(12), 1054–1058. Lidstone, S. C., Schulzer, M., Dinelle, K., Mak, E., Sossi, V., Ruth, T. J., & Stoessl, A. J. (2010). Effects of expectation on placebo-induced dopamine release in Parkinson disease. Archives of General Psychiatry, 67(8), 857–865. Plassmann, H., O'Doherty, J., Shiv, B., & Rangel, A. (2008). Marketing actions can modulate neural representations of experienced pleasantness. Proceedings of the National Academy of Sciences, 105(3), 1050–1054. Quattrone, A., Barbagallo, G., Cerasa, A., & Stoessl, A. J. (2018). Neurobiology of placebo effect in Parkinson's disease: What we have learned and where we are going. Movement Disorders, 33(8), 1213–1227. Robson, D. (2022). The expectation effect: How your mindset can transform your life. Canongate. Spence, C., & Piqueras-Fiszman, B. (2014). The perfect meal: The multisensory science of food and dining. John Wiley & Sons.

Featuring perspectives from Dr Floor J Backes, Dr Brian M Slomovitz and Dr Shannon N Westin, moderated by Dr Westin, including the following topics: Introduction (00:00) Current Up-Front Chemoimmunotherapeutic Approaches for Advanced Endometrial Cancer (EC) — Dr Backes (1:50) Current and Future Role of Anti-PD-1/PD-L1 Antibodies in Combination with Systemic Therapies Beyond Chemotherapy for Advanced EC — Dr Westin (33:15) Promising Agents Under Investigation for EC — Dr Slomovitz (1:01:41) CME information and select publications

Domestication of wheat Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, David Lordkipanidze recounts archaeological findings from Georgia expanding the history of bread wheat. In this episode, we cover: •[00:00] Introduction. •[00:51] Archaeologist and paleobotanist David Lordkipanidze tells about the archaeological sites where wheat samples were found. •[02:53] He talks about methods for identifying plant grains among archeological artifacts. •[04:49] Lordkipanidze explains the significance of finding bread wheat and goat grass grains together. •[06:45] He talks about how the findings change the origin story of bread wheat. •[08:28] He lists the caveats and limitations of the study. •[09:24] Conclusion. About Our Guest: David Lordkipanidze Director Georgia National Museum View related content here: https://www.pnas.org/doi/10.1073/pnas.2537697123 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

The sport of pickleball has become more than a passing fad. The equipment involved in the game, which include a hollow plastic ball perforated with holes, create some pretty unique sounds. In this episode we talk with Kathleen Romito and Jamie Banks (Quiet Communities) about their research into how pickleball noise affects bystanders. Associated paper: Kathleen M. Romito and Jamie Banks. "A survey of the community impact of pickleball noise: A pilot study." Proc. Mtgs. Acoust. 60, 040001 (2025) https://doi.org/10.1121/2.0002238.Read more from Proceedings of Meetings on Acoustics (POMA).Learn more about Acoustical Society of America Publications. Music Credit: Min 2019 by minwbu from Pixabay. 

On this episode, we're talking collections. Proceedings begin with a wrist check before Matt tells us about a collection that he has on loan, and then the fellas ask G about his collection.You can follow the pod on Insta @thatwatchpodcast and in case you hadn't heard, we're also on YouTube.

Featuring perspectives from Dr Farrukh T Awan, Dr Brad S Kahl, Ms Robin Klebig and Ms Mollie Moran, moderated by Dr Kahl, including the following topics: Introduction: Biology of Non-Hodgkin Lymphoma (NHL) (00:00) Current Role of CD20 x CD3 Bispecific Antibodies in NHL (4:49) Role of Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma (DLBCL) (27:48) Optimal Application of Loncastuximab Tesirine for Patients with DLBCL and Follicular Lymphoma (41:43) Role of Bruton Tyrosine Kinase (BTK) Inhibitors Alone or with Anti-CD20 Antibodies for Patients with Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) (1:00:43) Combining BTK Inhibitors with Bcl-2 Inhibitors (1:31:15) Current and Future Role of Noncovalent BTK Inhibitors in CLL (1:41:30) CME information and select publications

Featuring perspectives from Dr Ramez N Eskander, Dr Ursula Matulonis, Dr Kathleen N Moore, Dr Alexander B Olawaiye and Dr David M O'Malley, moderated by Dr Moore, including the following topics: Introduction (00:00) Current Role of PARP Inhibitors in the Management of Advanced Ovarian Cancer (OC) — Prof Eskander (2:40) Strategies Targeting Folate Receptor Alpha in Advanced OC — Dr Matulonis (27:41) Other Approved and Promising Investigational Antibody-Drug Conjugates for Advanced OC — Dr Moore (52:12) Other Novel Agents and Strategies for Advanced OC — Dr O'Malley (1:14:35) Diagnosis and Management of Adverse Events Associated with Common Therapies for Advanced OC — Dr Olawaiye (1:39:39) CME information and select publications

Preview for Later Today: Mark Simon discusses the ongoing imprisonment of six Apple Daily editors in Hong Kong. He details the irregular legal proceedings and the harsh ten-year sentences imposed on those deemed a threat to the state.

Featuring perspectives from Dr Floor J Backes, Dr Matthew A Powell and Dr Ritu Salani, moderated by Dr Salani, including the following topics: Case: A woman in her late 60s presents with mismatch repair-deficient metastatic endometrial cancer(00:00) Perspectives on neoadjuvant immunotherapy for microsatellite instability-high endometrial cancer (06:25) CME information and select publications

Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsAssmann, Jan. Death and Salvation in Ancient Egypt. Translated by David Lorton. Cornell University Press, 2005.Ariès, Philippe. The Hour of Our Death. Translated by Helen Weaver. Knopf, 1981.Beard, Mary, John North, and Simon Price. Religions of Rome. 2 vols. Cambridge University Press, 1998.Blackmore, Susan. Dying to Live: Near-Death Experiences. Prometheus Books, 1993.Boyce, Mary. Zoroastrians: Their Religious Beliefs and Practices. Routledge, 1979.Bremmer, Jan N. The Rise and Fall of the Afterlife: The 1995 Read-Tuckwell Lectures at the University of Bristol. Routledge, 2002.Chalmers, David J. “Facing Up to the Problem of Consciousness.” Journal of Consciousness Studies 2, no. 3 (1995): 200–219.Fenwick, Peter, and Elizabeth Fenwick. The Art of Dying: A Journey to Elsewhere. Continuum, 2008.Graf, Fritz, and Sarah Iles Johnston. Ritual Texts for the Afterlife: Orpheus and the Bacchic Gold Tablets. 2nd ed. Routledge, 2013.Greyson, Bruce. After: A Doctor Explores What Near-Death Experiences Reveal about Life and Beyond. St. Martin's Essentials, 2021.Greyson, Bruce. “The Near-Death Experience Scale: Construction, Reliability, and Validity.” Journal of Nervous and Mental Disease 171, no. 6 (1983): 369–375.Griffiths, Roland R., William A. Richards, Una McCann, and Robert Jesse. “Psilocybin Can Occasion Mystical-Type Experiences Having Substantial and Sustained Personal Meaning and Spiritual Significance.” Psychopharmacology 187, no. 3 (2006): 268–283.Hornung, Erik. The Ancient Egyptian Books of the Afterlife. Translated by David Lorton. Cornell University Press, 1999.Johnston, Sarah Iles. Restless Dead: Encounters between the Living and the Dead in Ancient Greece. University of California Press, 1999.Kerr, Christopher W., et al. “End-of-Life Dreams and Visions: A Longitudinal Study of Hospice Patients' Experiences.” Journal of Palliative Medicine 17, no. 3 (2014): 296–303.Le Goff, Jacques. The Birth of Purgatory. Translated by Arthur Goldhammer. University of Chicago Press, 1984.Moody, Raymond A. Life After Life. Mockingbird Books, 1975.Nahm, Michael, Bruce Greyson, Emily Williams Kelly, and Erlendur Haraldsson. “Terminal Lucidity: A Review and a Case Collection.” Archives of Gerontology and Geriatrics 55, no. 1 (2012): 138–142.Nelson, Kevin R., Michelle Mattingly, Sherman A. Lee, and Frederick A. Schmitt. “Does the Arousal System Contribute to Near Death Experience?” Neurology 66, no. 7 (2006): 1003–1009.Obayashi, Hiroshi, ed. Death and Afterlife: Perspectives of World Religions. Greenwood Press, 1992.Osis, Karlis, and Erlendur Haraldsson. At the Hour of Death. Avon, 1977.Parnia, Sam, et al. “AWAreness during REsuscitation—II: A Multi-Center Study of Consciousness and Awareness in Cardiac Arrest.” Resuscitation 191 (2023).Plato. Phaedo. In Plato: Complete Works. Edited by John M. Cooper. Hackett, 1997.Segal, Alan F. Life After Death: A History of the Afterlife in Western Religion. Doubleday, 2004.Stevenson, Ian. Children Who Remember Previous Lives: A Question of Reincarnation. Rev. ed. McFarland, 2001.Taylor, John H., ed. Journey through the Afterlife: Ancient Egyptian Book of the Dead. Harvard University Press / British Museum Press, 2010.Tucker, Jim B. Life Before Life: A Scientific Investigation of Children's Memories of Previous Lives. St. Martin's Press, 2005.van Gennep, Arnold. The Rites of Passage. Translated by Monika B. Vizedom and Gabrielle L. Caffee. University of Chicago Press, 1960.van Lommel, Pim, Ruud van Wees, Vincent Meyers, and Ingrid Elfferich. “Near-Death Experience in Survivors of Cardiac Arrest: A Prospective Study in the Netherlands.” The Lancet 358, no. 9298 (2001): 2039–2045.Xu, Gang, et al. “Surge of Neurophysiological Coupling and Connectivity of Gamma Oscillations in the Dying Human Brain.” Proceedings of the National Academy of Sciences 120, no. 19 (2023).Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. 

Featuring perspectives from Dr Floor J Backes, Dr Matthew A Powell and Dr Ritu Salani, moderated by Dr Salani, including the following topics: Case: A woman in her late 70s with de novo metastatic mismatch repair-proficient metastatic endometrioid endometrial cancer (00:00) Molecular analyses in the assessment and management of endometrial cancer (07:33) CME information and select publications

Featuring perspectives from Dr Christopher Flowers, Dr Matthew Lunning, Dr Sonali M Smith and Dr Brad S Kahl, moderated by Dr Kahl, including the following topics: Rational Incorporation of CD79b-Targeted Antibody-Drug Conjugates into the Management of Newly Diagnosed and Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL) — Dr Flowers (00:00) - Clinical Utility of CD19-Directed Monoclonal Antibodies in the Treatment of DLBCL and Follicular Lymphoma (FL) — Dr Smith (31:41) - Optimal Use of CD19-Directed Antibody-Drug Conjugates for R/R DLBCL and FL — Dr Lunning (01:03:23) - Current and Future Role of Bruton Tyrosine Kinase Inhibition in Therapy for Non-Hodgkin Lymphoma — Dr Kahl (01:26:48) CME information and select publications

Send us Fan MailIn this episode, I am offering something that has genuinely changed the way I think about my body — the circadian rhythm. I share what this 24-hour internal clock actually is, why researchers say it runs everything from your metabolism and hormones to your sleep and immunity, and how understanding it gave me a whole new perspective on the ongoing conversation around meal timing and breakfast. I walk through a few practical strategies rooted in circadian science that you can simply be aware of and explore in your own life.And yes — I am raising my hand on the late-night phone habit, because that quote of the week? It hit home for me too. Come learn something new about the incredible, intelligent design of your own body.QUOTE OF THE WEEK“Studies have shown that every hour you're still on your mobile phone, tablet, laptop, or watching TV at night, melatonin is suppressed by 30 minutes.”— Dr. Satchin Panda, The Circadian CodeCITATIONS ·      Panda, S. (2019). The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight. Rodale Books.·      Circadian rhythm science and the suprachiasmatic nucleus (SCN): National Institute of General Medical Sciences (NIGMS). Circadian Rhythms. U.S. Department of Health and Human Services. https://www.nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx·      Insulin sensitivity and meal timing: Saad, A., et al. (2012). Diurnal pattern to insulin secretion and insulin action in healthy individuals. Diabetes, 61(11), 2691–2700.·      Circadian disruption and metabolic health: Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009). Adverse metabolic and cardiovascular consequences of circadian misalignment. Proceedings of the National Academy of Sciences, 106(11), 4453–4458.·      Shift work and health outcomes: Wang, X. S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011). Shift work and chronic disease: the epidemiological evidence. Occupational Medicine, 61(2), 78–89.·      Social jet lag: Wittmann, M., Dinich, J., Merrow, M., & Roenneberg, T. (2006). Social jetlag: misalignment of biological and social time. Chronobiology International, 23(1-2), 497–509.·      Melatonin suppression and blue light/screens: Harvard Health Publishing. (2020). Blue light has a dark side. Harvard Medical School. https://www.health.harvard.edu/staying-healthy/blue-light-has-a-dark-side·      https://www.goodreads.com/work/quotes/59135872-the-circadian-code-lose-weight-supercharge-your-energy-and-transformLet's go, let's get it done.Get more information at: http://projectweightloss.org

「安慰剂」在新药研发过程中处处可见，amylose 和 amylopectin是安慰剂糖丸的主要成分，其实就是淀粉（标题注释）。安慰剂效应究竟是应该被消除的统计噪声，还是一种被低估的真实治疗机制？当一针生理盐水能让帕金森患者的大脑释放出与真药相当的多巴胺，当假手术的疗效与真手术完全持平。我们要回答的问题是：如果安慰剂这么强，新药研发的投入还有意义吗？如果安慰剂能治病，我们可以只给病人吃糖丸吗？这期节目我们一起聊聊安慰剂效应在大脑中究竟通过哪些神经通路起效；它为什么越来越强以至于成为新药研发的障碍；我们可以只用安慰剂来治病吗？时间轴[00:14] 怀特先生的故事：一针盐水就让肿瘤消失了[02:54] 二战护士用生理盐水冒充吗啡止痛，战士不疼了[06:22] 不光吃药，手术也有安慰剂效应[12:32] 安慰剂不光能安慰，还能「反安慰」[19:10] 安慰剂管用的三条神经通路：内源性阿片系统、多巴胺奖赏系统、HPA 轴[28:32] 安慰剂成了新药上市的绊脚石[39:31] 临床试验如何对付安慰剂效应[44:14] 只用安慰剂能治病吗？

Featuring perspectives from Prof Giuseppe Curigliano, Prof Rebecca A Dent, Dr Erika Hamilton, Prof Nadia Harbeck and Dr Hope S Rugo, moderated by Dr Rugo, including the following topics: Introduction (00:00) Evolving Role of Antibody-Drug Conjugates (ADCs) in the Management of Metastatic Triple-Negative Breast Cancer — Prof Dent (02:57) Integrating ADCs into the Management of HER2-Positive Metastatic Breast Cancer (mBC) — Prof Curigliano (29:01) Role of ADCs in the Management of Endocrine-Resistant Hormone Receptor-Positive mBC — Dr Rugo (52:36) Emerging Utility of ADCs for Localized Breast Cancer — Prof Harbeck (01:14:36) Tolerability Considerations with ADCs for Breast Cancer — Dr Hamilton (01:38:10) CME information and select publications

It is rare to find someone in the field of intellectual property, in particular patent law, who is a scholar and a practitioner. Today, we have with us Jay Kesan who is both. Listen in for a great episode full of information about the PTAB (Patent Trial and Appeal Board) and the impact it has had on the patent system after 10 years. In this episode, Jeff Harty and Jay Kesan discuss: Jay's professional career as both a law professor and a practicing patent attorney/litigator. The impact of IPRs and PGRs on the patent system. Challenging the validity of a patent in an IPR proceeding versus district court litigation. Key Takeaways: The PTAB was created as an alternative forum for challenging issued patents. It was hoped that the PTAB would provide a lower-cost means of challenging already-issued patents.In the past few years, the number of patent validity challenges has leveled out to about 1,500 IPRs per year.The vast majority of IPRs involve parallel district court infringement actions.The USPTO, under its new director, has issued new guidelines for discretionary denials of PTAB proceedings. A fair comment, at this stage, would be that these discretionary denials are only going to continue to decrease even when there is parallel district court litigation.“If you're a patent owner and you believe that your patents are being infringed and you're contemplating an infringement action, you have to take into account the new world that you have to deal with.” — Jay Kesan   About Jay Kesan: Jay P. Kesan, Ph.D., J.D., is a well-recognized and accomplished patent attorney with more than 25 years' experience. His work encompasses all aspects of patent enforcement, patent strategy, and licensing. He has been lead counsel or co-counsel in numerous patent lawsuits in various federal district courts around the country. He has argued numerous appeals before the Court of Appeals in the Federal Circuit. He has also served as lead counsel in more than 30 IPRs and argued several times before the PTAB. He has been actively involved in every aspect of patent litigation as counsel, Special Master, appellate counsel, technical expert, legal expert, and mediator.Jay has a Ph.D. in electrical and computer engineering from the University of Texas at Austin and worked for several years as a research scientist at the IBM Thomas J. Watson Research Center. As a result, he works with clients on IP disputes that involve a wide variety of technologies and innovations.Jay is also an active empirical scholar, and his recent works have focused on cyber risk and patent policy. He has published numerous articles and six books on patent law and policy and cybersecurity and privacy with an emphasis on empirical research methodologies.He is a professor and H. Ross and Helen Workman Research Scholar at the University of Illinois at Urbana-Champaign. He is an active and widely cited scholar.Connect with Jay Kesan: Website: https://jaykesan.com/ Email: jay@jaykesan.com Books: https://jaykesan.com/books/ Twitter: https://twitter.com/JayKesanP LinkedIn: https://www.linkedin.com/in/jaykesan/ YouTube: https://www.youtube.com/channel/UCENwROk5ywajSVoJWUX9SBA/featured Connect with Jeff Harty: Website: https://nyemaster.com/attorney-directory/jeffrey-d-harty/Email: jharty@nyemaster.comLinkedIn: https://www.linkedin.com/in/jeff-harty-5a9a1643/

About this episode:   Telling a good joke is a science—it requires gathering data, thoughtful analysis, and constant experimentation to get it right. A good joke can also help us better communicate about science. In this episode: A stand-up comedian with a research background explains why comedy is a useful tool in science communication and shares tips for using humor to illustrate academic concepts. Guest:  Sarah Adelman, MPH, is a stand-up comic, screenwriter, and former scientist. She is also the creator, host, and executive producer of the original social media series "BLOW MY MIND." Host:  Lindsay Smith Rogers, MA, is the producer of the Public Health On Call podcast, an editor for Expert Insights, and the director of content strategy for the Johns Hopkins Bloomberg School of Public Health.  Show links and related content:  A Scientist Walks Into a Bar…—Nautilus Not Just Funny After All: Sarcasm as a Catalyst for Public Engagement With Climate Change—Science Communication Can a Joke Make Science More Trustworthy?—Journal of Science Communication Specialized terminology reduces the number of citations of scientific papers—Proceedings of the Royal Society B: Biological Sciences Why Do We Believe Misinformation?—Public Health On Call (December 2025) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Featuring perspectives from Ms Courtney Arn, Ms Jamie Carroll, Dr Edward B Garon, Dr Heather McArthur and Dr Kathleen N Moore, moderated by Dr Moore, including the following topics: Introduction (0:00) Overview of Antibody-Drug Conjugates (ADCs) (2:07) Current and Future Role of HER2-Targeted ADCs for Breast Cancer (6:23) Currently Available ADCs for Gynecologic Cancer Management (26:37) Currently Available ADCs for Lung Cancer Management (44:07) Current and Future Role of TROP2-Targeted ADCs for Metastatic Breast Cancer (56:55) Other ADCs That May Soon Reach the Clinic for Advanced Gynecologic Cancers (1:15:07) Promising Investigational Strategies Employing ADCs for Lung Cancer (1:25:01) NCPD information and select publications  

REPEAT. ICYMI. Hope you're all having a great summer. We didn't get a chance to record another podcast episode recently and I don't quite feel ready to call it quits on this season just yet, so we might release a couple of new episodes over the summer, you'll just have to watch this space. In the meantime, I wanted to re-release this episode with the incredible Dr Sparky Booker, Assistant Professor in Medieval Irish History, Trinity College Dublin, in case anyone missed it. Sparky enlightens us on the legal systems in force in 14th and 15th century Ireland, how to keep your land and why Elizabeth Le Veele married King of Leinster, Art McMurrough. She also discusses how the prevalence of intermarriage in the so-called 'four obedient shires' indicates that the English and Irish interacted far more peaceably and amicably than the often belligerent attitudes displayed toward the Irish in records from the colony would indicate, and that the attempts made by the Irish parliament to distance the English of Ireland from their Irish neighbours were largely unsuccessful.Suggested reading:Sparky Booker, Cultural Exchange and Identity in late medieval Ireland: the English and Irish of the Four Obedient Shires, Studies in Medieval Life and Thought Series (Cambridge, 2018)Sparky Booker, ‘Women and legal history: the case of late medieval English Ireland and the challenges of studying ‘women'', Irish Historical Studies, 46:170 (2022), pp 224-243Sparky Booker, ‘Intermarriage in fifteenth-century Ireland: the English and Irish in the ‘four obedient shires', Proceedings of the Royal Irish Academy, 113c (2013), pp 219-250Sparky Booker, ‘Widowhood and attainder in medieval Ireland: the case of Margaret Nugent' in Deborah Youngs and Teresa Phipps (eds), Litigating women: gender and justice in Europe, c.1300-c.1800 (Abingdon, 2022), pp 81-98Ellis, Stephen G. (1998). Ireland in the Age of the Tudors, 1447-1603: English Expansion and the End of Gaelic Rule (2nd ed.). RoutledgeRegular episodes every month (on a Friday)Email: medievalirishhistory@gmail.comProducer: Tiago Veloso SilvaSupported by the Dept of Early Irish, Maynooth University & Taighde Éireann/Research Ireland.Views expressed are the speakers' own.Logo design: Matheus de Paula CostaMusic: Lexin_Music

Featuring perspectives from Dr Alexandra Drakaki, Ms Krisztina Emodi, Dr Terence Friedlander and Ms Margarita Huober, moderated by Dr Friedlander, including the following topics: Introduction: Basic Biology of Nonmetastatic Urothelial Bladder Cancer (UBC) (0:00) Systemic Therapy for Cisplatin-Eligible Patients with Muscle-Invasive Bladder Cancer (MIBC) (13:35) Evolving Approach to Systemic Therapy for Cisplatin-Ineligible Patients with MIBC (37:13) Immune Checkpoint Inhibitors in Non-Muscle-Invasive Bladder Cancer (58:55) Novel Intravesical Therapies for Nonmetastatic UBC (1:10:20) NCPD information and select publications

World-leading behaviour change expert Katy Milkman details how to change your habits.  --- Become an FSB member: https://get.fsb.org.uk/nudge/ Unlock the Nudge Vaults: https://www.nudgepodcast.com/vaults Katy's book: https://amzn.to/3RF63xA  Katy's podcast: https://www.schwab.com/learn/choiceology  Katy's newsletter: https://www.katymilkman.com/newsletter-milkman-delivers  Subscribe to my newsletter: https://www.nudgepodcast.com/mailing-list  Connect on LinkedIn: https://www.linkedin.com/in/phill-agnew/  --- Today's sources: Beshears, J.Beshears, J., Dai, H., Milkman, K. L., & Benartzi, S. (2021). Using fresh starts to nudge increased retirement savings. Organizational Behavior and Human Decision Processes, 167, 72–87. Dai, H., Milkman, K. L., & Riis, J. (2014). The fresh start effect: Temporal landmarks motivate aspirational behavior. Management Science, 60(10), 2563–2582. Eskreis-Winkler, L., Fishbach, A., & Duckworth, A. L. (2018). Dear Abby: Should I give advice or receive it? Psychological Science, 29(11), 1797–1806. Eskreis-Winkler, L., Milkman, K. L., Gromet, D. M., & Duckworth, A. L. (2019). A large-scale field experiment shows giving advice improves academic outcomes for the advisor. Proceedings of the National Academy of Sciences, 116(30), 14808–14810. Schroeder, S. A. (2007). We can do better — Improving the health of the American people. New England Journal of Medicine, 357(12), 1221–1228.

In Part 2 of The Mechanics of Magick: Drumming, Trance, and the Brain, we follow rhythm from the sacred road into the war road and the modern machine. This episode examines war drums, military cadence, synchronized movement, crowd power, ritual physiology, propaganda, slogans, media framing, algorithmic repetition, moral-emotional contagion, and the illusory truth effect. The argument is not that rhythm is evil. The argument is that rhythm is morally flexible and powerful. It can heal, gather, strengthen, command, manipulate, or capture depending on the world built around it. The drum teaches us to hear the visible pulse first, so we can recognize the hidden drums of the modern world: the chant, the slogan, the feed, the notification loop, the soundtrack, the repeated frame, and the rhythm that trains attention before thought has time to speak.Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsRhythm, Marching, Synchrony, and the GroupBodyMcNeill, William H. Keeping Together in Time: Dance and Drill in Human History. Cambridge, MA: Harvard University Press, 1995.Use for dance, drill, marching, synchronized movement, and “muscular bonding.” This is one of the best historical anchors for the claim that moving together in time can help bind human groups through the body. It belongs in the war drum, marching, military cadence, procession, and crowd-power material.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5.Use for the claim that synchronized action can increase cooperation. This supports the argument that marching, chanting, dancing, and acting in time can alter group attachment and behavior.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960.Use for interpersonal synchrony and affiliation. This supports the softer social-bonding side of rhythm: people who coordinate timing can feel more connected.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096.Use for music, synchrony, bonding, self-other merging, endorphins, and why rhythmic group activity can feel socially powerful. This belongs in both crowd sections and the “operator as instrument” material.Reddish, Paul, Ronald Fischer, and Joseph Bulbulia. “Let's Dance Together: Synchrony, Shared Intentionality and Cooperation.” PLOS ONE 8, no. 8 (2013): e71182.Use as extra support for synchrony and cooperation. Good optional source if you want more than Wiltermuth and Heath.Ritual Physiology, Crowd Arousal, and Collective EffervescenceKonvalinka, Ivana, Dimitris Xygalatas, Joseph Bulbulia, Uri Schjødt, Else-Marie Jegindø, Sebastian Wallot, Guy Van Orden, and Andreas Roepstorff. “Synchronized Arousal Between Performers and Related Spectators in a Fire-Walking Ritual.” Proceedings of the National Academy of Sciences 108, no. 20 (2011): 8514–8519.Use for the strongest fire-walking physiology source. This is the study showing synchronized arousal between active ritual performers and related spectators. It supports the claim that intense ritual fields can show up in bodies, not only in symbols.Xygalatas, Dimitris, Ivana Konvalinka, Joseph Bulbulia, and Andreas Roepstorff. “Quantifying Collective Effervescence: Heart-Rate Dynamics at a Fire-Walking Ritual.” Communicative & Integrative Biology 4, no. 6 (2011): 735–738.Use as a shorter interpretive companion to the PNAS fire-walking study. Good for the phrase “collective effervescence” and for explaining shared heart-rate dynamics in accessible language.Xygalatas, Dimitris. Ritual: How Seemingly Senseless Acts Make Life Worth Living. New York: Little, Brown Spark, 2022.Use for ritual, pain, synchrony, group bonding, arousal, and embodied social meaning. This is useful when moving from older ritual containers into modern crowd and spectacle.Hobson, Nicholas M., Juliana Schroeder, Jane L. Risen, Dimitris Xygalatas, and Michael Inzlicht. “The Psychology of Rituals: An Integrative Review and Process-Based Framework.” Personality and Social Psychology Review 22, no. 3 (2018): 260–284.Use for ritual as emotion regulation, performance regulation, social bonding, and formalized action. This supports the “ritual does things, it does not merely represent things” argument.War, Crowds, Mass Movements, and Collective IdentityLe Bon, Gustave. The Crowd: A Study of the Popular Mind. 1895.Use carefully. Le Bon is historically important for crowd psychology, but outdated and often elitist. Good as a historical source on crowd fear and mass suggestion, but balance it with modern social psychology.Canetti, Elias. Crowds and Power. New York: Viking Press, 1962.Use for a literary-philosophical treatment of crowds, power, command, fear, and collective bodies. Good for atmosphere and conceptual framing, not as a modern experimental source.Hoffer, Eric. The True Believer: Thoughts on the Nature of Mass Movements. New York: Harper & Brothers, 1951.Use for mass movements, fanaticism, belonging, identity, resentment, sacrifice, and the psychology of ideological devotion. Use carefully; it is sharp and useful, but not a modern empirical study.Tajfel, Henri, and John C. Turner. “An Integrative Theory of Intergroup Conflict.” In The Social Psychology of Intergroup Relations, edited by William G. Austin and Stephen Worchel, 33–47. Monterey, CA: Brooks/Cole, 1979.Use for social identity theory, in-groups, out-groups, belonging, status, and group comparison. This supports the claim that slogans and group language do not only communicate ideas; they also mark identity.Tajfel, Henri. Human Groups and Social Categories: Studies in Social Psychology. Cambridge: Cambridge University Press, 1981.Use as a broader social-identity source. Good for group belonging, categorization, prejudice, and in-group/out-group dynamics.Propaganda, Symbols, Slogans, and Mass CommunicationLasswell, Harold D. Propaganda Technique in the World War. New York: Alfred A. Knopf, 1927.Use for propaganda as symbolic management, war messaging, enemy construction, morale, and the manipulation of attitudes through stories, reports, images, rumors, and other significant symbols. This is a core Part 2 source.Lasswell, Harold D. “The Theory of Political Propaganda.” The American Political Science Review 21, no. 3 (1927): 627–631.Use for the clean definition: propaganda as the management of collective attitudes through significant symbols. This is perfect for the slogan/crowd/media rhythm sections.Ellul, Jacques. Propaganda: The Formation of Men's Attitudes. Translated by Konrad Kellen and Jean Lerner. New York: Alfred A. Knopf, 1965.Use for propaganda as a modern social technique, not merely lies. Ellul belongs in the “modern machine” argument because he treats propaganda as environmental, repetitive, social, technological, and tied to belonging.Bernays, Edward. Propaganda. New York: Horace Liveright, 1928.Use for public relations, engineered consent, mass persuasion, and the management of public opinion. Good supporting source, especially if you want advertising and PR to sit beside political propaganda.Herman, Edward S., and Noam Chomsky. Manufacturing Consent: The Political Economy of the Mass Media. New York: Pantheon Books, 1988.Use if you want a media-system critique: institutional filtering, agenda power, elite framing, and consent formation. This is useful for Part 2 but has a more political-economy angle than the rhythm/trance argument.Media Framing, Agenda-Setting, and Repeated AttentionMcCombs, Maxwell E., and Donald L. Shaw. “The Agenda-Setting Function of Mass Media.” Public Opinion Quarterly 36, no. 2 (1972): 176–187.Use for agenda-setting: media may not tell people exactly what to think, but it can influence what people think about and how important issues feel. This fits the “repetition trains attention” argument.Entman, Robert M. “Framing: Toward Clarification of a Fractured Paradigm.” Journal of Communication 43, no. 4 (1993): 51–58.Use for framing: selecting certain aspects of reality and making them more salient. This supports the section on media frames as secular ritual structures that define problems, causes, moral judgments, and remedies.Gitlin, Todd. The Whole World Is Watching: Mass Media in the Making and Unmaking of the New Left. Berkeley: University of California Press, 1980.Use if you want a historical case study on media framing and protest movements. Good optional source for how movements get shaped, simplified, or distorted by media attention.Postman, Neil. Amusing Ourselves to Death: Public Discourse in the Age of Show Business. New York: Viking Penguin, 1985.Use as cultural/media theory support for entertainment, spectacle, image, and public discourse. Useful for the “modern machine” angle, but more essayistic than experimental.Repetition, Familiarity, and the Illusory Truth EffectHasher, Lynn, David Goldstein, and Thomas Toppino. “Frequency and the Conference of Referential Validity.” Journal of Verbal Learning and Verbal Behavior 16, no. 1 (1977): 107–112.Use for the classic repetition/familiarity basis of the illusory truth effect. This supports the claim that repeated statements can gain perceived validity because they become easier and more familiar to processAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. 

Send us Fan MailWe've all used the phrase "real people" — meaning the regular folks, the everyday ones, as opposed to the famous, the wealthy, the powerful. But what if that whole distinction is a lie? This week, I'm pulling apart the binary between "ordinary" and "extraordinary" — sharing a story from my own childhood, a lesson from my years writing public policy, and some genuinely surprising research on what actually makes us alike. Spoiler: the line between you and a billionaire is a lot thinner than either of you think. Grab your coffee — this one's personal. Quote of the Week “If it's not accessible to the poor, it is neither radical nor revolutionary” Citations·       Witherspoon, D.J., Wooding, S., Rogers, A.R., et al. (2007). Genetic similarities within and between human populations. Genetics, 176(1), 351–359. https://doi.org/10.1534/genetics.106.067355·       Ekman, P., Friesen, W.V., O'Sullivan, M., et al. (1987). Universals and cultural differences in the judgments of facial expressions of emotion. Journal of Personality and Social Psychology, 53(4), 712–717. https://pubmed.ncbi.nlm.nih.gov/3681648/·       Systematic review (2025) of 21 peer-reviewed studies (1972–2024) on cultural differences in the production of emotional facial expressions. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC12907163/·       Killingsworth, M.A. (2024). Money and Happiness: Extended Evidence Against Satiation. Happiness Science. https://happiness-science.org/money-happiness-satiation/·       Killingsworth, M.A., Kahneman, D., Mellers, B. (2023). Income and emotional well-being: A conflict resolved. Proceedings of the National Academy of Sciences, 120. (referenced in CBC coverage: https://www.cbc.ca/radio/costofliving/money-can-buy-happiness-1.7107592)·       "If it's not accessible to the poor, it is neither radical nor revolutionary" — widely circulated activist quote since at least 2016; original source unattributed. Let's go, let's get it done.Get more information at: http://projectweightloss.org

In breaking news, the Trump Administration, its DOJ and its Homeland Security Department have moved one step closer to the possibility of being found in Criminal Contempt and someone going to jail, as the US Court of Appeals/DC has agreed to the urging of 174 Former Judges, and have tossed a prior opinion by a Trump dominated panel to block the trial judge's criminal contempt proceedings and investigation, and will hear the case by all 11 judges of the Court instead. Popok explains how this case started and the implications of the En Banc ruling up to the US Supreme Court. Americans United will keep fighting for freedom without favor - equality without exception. Keep up with this issue at https://au.org/legalaf Subscribe:  @LegalAFMTN  Visit https://meidasplus.com for more! Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: https://www.meidastouch.com/tag/meidastouch-podcast Legal AF: https://www.meidastouch.com/tag/legal-af MissTrial: https://meidasnews.com/tag/miss-trial The PoliticsGirl Podcast: https://www.meidastouch.com/tag/the-politicsgirl-podcast Cult Conversations: The Influence Continuum with Dr. Steve Hassan: https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan The Weekend Show: https://www.meidastouch.com/tag/the-weekend-show The Ken Harbaugh Show: https://meidasnews.com/tag/the-ken-harbaugh-show Majority 54: https://www.meidastouch.com/tag/majority-54 On Democracy with FP Wellman: https://www.meidastouch.com/tag/on-democracy-with-fpwellman Uncovered: https://www.meidastouch.com/tag/maga-uncovered Learn more about your ad choices. Visit megaphone.fm/adchoices

Featuring perspectives from Dr Dana M Chase, Ms Sarah Karpen, Dr J Alejandro Rauh-Hain and Ms Jaclyn Shaver, moderated by Dr Chase, including the following topics: Introduction: Biology of Endometrial Cancer (EC) (0:00) First-Line Therapy for Advanced or Recurrent EC (14:15) Potential Benefits of PARP Inhibition Combined with Immunotherapy in Advanced EC (35:13) Role of Lenvatinib/Pembrolizumab in the Management of Progressive Advanced EC (57:48) Other Nursing Considerations in the Care of Patients with Advanced EC (1:17:28) NCPD information and select publications

In this episode of the Get Obsessed podcast, Dr. Robert Epstein, psychologist, author, and Senior Research Psychologist at the American Institute for Behavioral Research and Technology, joins hosts Julie Lokun and Mika Altidor to discuss the growing influence of Google and other technology companies on privacy, behavior, and society. Drawing from years of research, congressional testimony, and investigations into online manipulation, Dr. Epstein explains how search engines, online surveillance, and algorithmic systems can shape decisions without users realizing it. The conversation explores digital hygiene, election interference, artificial intelligence (AI), internet addiction, and practical ways individuals can protect their data privacy in an increasingly connected world. In this episode, we discuss: How Dr. Epstein's research initially showed Google's unexpected power to shift voters  Why Google's reach extends far beyond search and what that means for everyday users Practical digital hygiene habits and tools that can help protect privacy online Research showing how search results can influence opinions, decisions, and elections How phones, smart devices, and connected technology contribute to online surveillance Why artificial intelligence may increase the power of tech companies to monitor and influence behavior Concerns about children, internet addiction, AI-generated content, and the future of digital autonomy    ABOUT THE GUEST: Dr. Robert Epstein is an author, editor, professor, and Senior Research Psychologist at the American Institute for Behavioral Research and Technology. A former Editor in Chief of Psychology Today, he has spent decades researching human behavior, technology, and online influence.  He earned his PhD in psychology from Harvard University and is the founder and Director Emeritus of the Cambridge Center for Behavioral Studies. His research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences, and he is widely known for identifying the Search Engine Manipulation Effect (SEME), which explores how search rankings can influence opinions and voting behavior. Dr. Epstein has testified before the United States Congress on election interference, Big Tech influence, and digital manipulation. He has authored or edited 15 books and has appeared on major media platforms including The Joe Rogan Experience, NPR, Voice of America, and SiriusXM.   MENTIONED IN THE EPISODE:  (Podcast) The Joe Rogan Experience featuring Dr. Robert Epstein (2022) - https://EpsteinOnRogan.com (Podcast) The Joe Rogan Experience featuring Dr. Robert Epstein (2023) - https://EpsteinOnRogan2.com (Video) Dr. Epstein's 2023 Congressional Testimony - https://2023EpsteinTestimony.com (Video) Dr. Epstein's 2019 Congressional Testimony - https://EpsteinTestimony.com (Website) My Digital Hygiene - https://MyDigitalHygiene.com (Website) America's Digital Shield - https://americasdigitalshield.com/ (Website) My Privacy Tips - https://myprivacytips.com/ (Website) Epstein Addiction Inventory - https://areyouaddicted.org/ CONNECT WITH DR. ROBERT EPSTEIN: Website: https://drrobertepstein.com/ Twitter: https://twitter.com/DrREpstein LinkedIn: https://www.linkedin.com/in/dr-robert-epstein-drrepstein-0658b2/   ABOUT GET OBSESSED Website: www.getobsessedpodcast.com Be a Guest! http://www.getobsessedguest.com  Reach Out To Us! hello@getobsessedmedia.com  The Get Obsessed podcast is dedicated to exploring the passions, mindsets, and habits that drive high performers. We believe that what you obsess over defines your future. LISTEN, RATE, REVIEW AND SUBSCRIBE - Get Obsessed : With Living Your Best Life - Podcast - Apple Podcasts Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The story of the Roman catacombs is vastly different than that of the catacombs of Paris, as Rome’s are much older and were created for very different reasons. Research: Bonello, Giovanni. “Charting the enigmatic life of Antonio Bosio.” Times of Malta. Dec. 6, 2014. https://timesofmalta.com/article/Charting-the-enigmatic-life-of-Antonio-Bosio.547468 Bonello, Giovanni. “How Antonio Bosio Became famous Worldwide.” Times of Malta. Dec. 13, 2014. https://timesofmalta.com/article/How-Antonio-Bosio-became-famous-worldwide.548393 Bosio, Antonio. “Roma sotteranea.” 1650. Accessed online: https://books.google.com/books?id=zCXXSKqq3nQC&printsec=frontcover&source=gbs_atb#v=onepage&q&f=false Britannica Editors. "Edict of Milan". Encyclopedia Britannica, 8 Aug. 2019, https://www.britannica.com/topic/Edict-of-Milan Britannica Editors. "First Jewish Revolt". Encyclopedia Britannica, 31 Mar. 2025, https://www.britannica.com/event/First-Jewish-Revolt Britannica Editors. "Law of the Twelve Tables". Encyclopedia Britannica, 29 Mar. 2018, https://www.britannica.com/topic/Law-of-the-Twelve-Tables “The Catacombs of Rome.” The Atlantic Monthly. March 1858. https://www.theatlantic.com/magazine/archive/1858/03/the-catacombs-of-rome/627225/ Coleman-Norton, Paul R. “The Twelve Tables.” 2024 (eBook). https://www.gutenberg.org/cache/epub/14783/pg14783-images.html “Diocletianic Persecution.” Ebsco. 2023. https://www.ebsco.com/research-starters/religion-and-philosophy/diocletianic-persecution “Jews in Roman Times.” The Roman Empire. PBS. https://www.pbs.org/empires/romans/empire/jews.html Lamberton, Clark D. “The Development of Christian Symbolism as Illustrated in Roman Catacomb Painting.” American Journal of Archaeology, vol. 15, no. 4, 1911, pp. 507–22. JSTOR, https://doi.org/10.2307/497187 Munro, Dana Carleton et al. “Translations and reprints from the original sources of European history : series for 1897.” University of Pennsylvania. 1898. https://archive.org/details/translationsrepr00munr/page/n3/mode/2up Northcote, James Spencer. “The Roman Catacombs.” Sophia Institute Press. 2017. (Reprint) Northcote, James Spencer. ““The Roman Catacombs; or Some Accounts of the Burial Places of the Early Christians in Rome.” Philadelphia. Peter F. Cunningham. 1857. (Reprint) Osborne, J. “The Roman Catacombs in the Middle Ages.” Papers of the British School at Rome , 1985, Vol. 53 (1985), pp. 278-328. https://www.jstor.org/stable/40310821 Perrottet, Tony. “Explore Rome’s Hidden Underworld, Where a City Lurks Beneath a City.” Smithsonian. April/May 2025. https://www.smithsonianmag.com/travel/explore-romes-hidden-underworld-city-beneath-city-180986228/ “PONTIFICAL COMMISSION FOR SACRED ARCHAEOLOGY – Historical Notes.” Vatican. https://www.vatican.va/roman_curia/pontifical_commissions/archeo/inglese/documents/rc_com_archeo_doc_20011010_cenni_en.html Richter, J. P. “Early Christian Art in the Roman Catacombs.” The Burlington Magazine for Connoisseurs, vol. 6, no. 22, 1905, pp. 286–262. JSTOR, http://www.jstor.org/stable/856226 “The Roman Catacombs.” Architecture. April 20, 1888. No. 414, p. 224. https://babel.hathitrust.org/cgi/pt?id=nyp.33433084078983&seq=414&q1=catacombs “The Roman Catacombs.” Scientific American, vol. 58, no. 20, 1888, pp. 312–312. JSTOR, http://www.jstor.org/stable/26094597 Rossi, Giovannie Battista de, et all. “Roma sotterranea : or, Some account of the Roman catacombs, especially of the cemetery of San Callisto ; comp. from the works of Commendatore de Rossi with the consent of the author.” Longmans, Green, Reader and Dyer. London. 1869. https://archive.org/details/a606740800rossuoft/a606740800rossuoft/page/6/mode/2up RUTGERS, LEONARD VICTOR, and לאונרד רוטגרס. “הקטקומבות היהודיות ברומא: הערכה מחודשת / THE JEWISH CATACOMBS OF ROME RECONSIDERED.” Proceedings of the World Congress of Jewish Studies / דברי הקונגרס העולמי למדעי היהדות, י, 1989, pp. 29–36. JSTOR, http://www.jstor.org/stable/23535611 Terry, Andrea, and John Osborne. “Un Canadien Errant: Charles Smeaton and the Earliest Photographs of the Roman Catacombs.” RACAR: Revue d’art Canadienne / Canadian Art Review, vol. 32, no. 1/2, 2007, pp. 94–106. JSTOR, http://www.jstor.org/stable/42630755 Yeomans, Sarah. “City of the Dead.” Archaeology, vol. 61, no. 4, 2008, pp. 55–62. JSTOR, http://www.jstor.org/stable/41780388 See omnystudio.com/listener for privacy information.

What if the same brain states people spend years chasing through psychedelics could be accessed through meditation alone, and in as little as seven days? In this fascinating solo episode, Darin Olien explores groundbreaking new research from University of California San Diego, Harvard University, Massachusetts General Hospital, and University of Montreal suggesting that meditation may produce brain patterns remarkably similar to those observed during psychedelic experiences. From the suppression of the default mode network and increases in neural complexity to neuroplasticity, endogenous opioids, and measurable biological changes in the bloodstream, Darin unpacks the science behind one of the most powerful, and completely free tools available to human beings. He also walks listeners through a practical seven-day protocol combining focused-attention meditation, Vipassana, breathwork, walking meditation, and loving-kindness practices designed to help cultivate greater awareness, emotional resilience, cognitive flexibility, and inner peace. What You'll Learn The groundbreaking UC San Diego meditation study and its surprising findings Why meditation may create brain states similar to psilocybin What the default mode network is and how it shapes everyday thinking How meditation may reduce rumination, anxiety, and self-referential thought The concept of brain criticality and cognitive flexibility Why post-meditation blood samples stimulated neuronal growth How meditation influences neuroplasticity and whole-body biology The differences between Samatha and Vipassana meditation What advanced monks are teaching scientists about consciousness The limitations and caveats of current meditation research A practical seven-day meditation protocol anyone can begin Why meditation may be one of the most powerful health interventions available today Chapters 00:00:03 – Welcome to SuperLife 00:00:33 – Sponsor: Alkemis and the hidden toxicity of indoor air 00:00:57 – Conventional paints, petrochemicals, and endocrine disruptors 00:01:24 – Why VOCs and PFAS may be affecting your home environment 00:01:55 – Fire-resistant mineral paints and healthier living spaces 00:02:27 – Cradle to Cradle certification and sustainable design 00:03:23 – The meditation study Darin can't stop thinking about 00:03:33 – Scanning the brains and blood of meditators 00:03:44 – Brain activity resembling psilocybin experiences 00:04:09 – The promise of a seven-day meditation protocol 00:04:22 – Psychedelics, consciousness, and dissolving the sense of self 00:04:47 – Ancient practices and modern scientific validation 00:05:23 – Why meditation research is entering a renaissance 00:05:41 – Harvard, Massachusetts General Hospital, and advanced consciousness mapping 00:06:00 – University of Montreal's study of monks with 15,000+ hours of practice 00:06:16 – Why psychedelics and meditation are converging scientifically 00:06:37 – What listeners will learn in today's episode 00:06:54 – Breaking down the UC San Diego retreat study 00:07:18 – Thirty-three hours of meditation, breathwork, and group practice 00:07:42 – EEG scans, blood draws, and laboratory neuron testing 00:08:05 – Reduced activity in the default mode network 00:08:24 – The science of mental chatter and rumination 00:08:50 – Blood plasma stimulating new neuronal growth 00:09:02 – Neuroplasticity and new neural connections 00:09:29 – Increased cellular metabolism and endogenous opioids 00:10:13 – Samatha vs Vipassana meditation explained 00:10:42 – How different meditation styles reshape the brain 00:10:50 – Harvard's advanced meditation consciousness studies 00:11:18 – Mapping concentration states and consciousness cessation 00:11:46 – Ancient contemplative traditions meeting modern neuroscience 00:11:50 – Important limitations of the research 00:12:05 – Why advanced monks aren't average practitioners 00:12:20 – Correlation versus causation in psychedelic comparisons 00:12:48 – What may actually be happening inside the brain 00:13:03 – Understanding the default mode network 00:13:26 – Anxiety, depression, addiction, and overactive self-talk 00:13:53 – Why meditation and psilocybin share common neurological effects 00:14:10 – Beginner studies showing measurable brain changes 00:14:28 – Brain criticality and cognitive adaptability 00:14:48 – The most surprising finding: meditation changes the blood 00:15:05 – Meditation as a whole-body signaling event 00:15:18 – Better sleep, digestion, hormone balance, and recovery 00:15:39 – Neuroplasticity, immune function, metabolism, and pain regulation 00:15:56 – Why meditation may be the ultimate free medicine 00:16:10 – Introducing the seven-day meditation protocol 00:16:34 – Sponsor break: Alkemis Paint 00:19:02 – Building a research-backed at-home meditation practice 00:19:24 – Why consistency matters more than total hours 00:19:41 – Combining focused attention and open monitoring 00:19:53 – Days 1–3: Stabilizing attention 00:20:02 – Morning focused-attention meditation instructions 00:20:34 – Evening body scan practice 00:21:04 – Preparing the brain for deeper awareness 00:21:08 – Days 4–5: Opening awareness through Vipassana 00:21:31 – Letting thoughts, sensations, and sounds pass freely 00:21:39 – Evening box breathing for nervous system regulation 00:22:01 – Why days four and five often feel more challenging 00:22:11 – Days 6–7: Deepening and integrating the practice 00:22:27 – Walking meditation and embodied awareness 00:22:52 – Loving-kindness meditation and compassion training 00:23:02 – Vagal tone, heart rate regulation, and inflammation reduction 00:23:18 – Three rules that determine success 00:23:26 – Eliminating distractions and protecting attention 00:23:36 – Why you should never judge your meditation sessions 00:24:00 – Extending the practice beyond seven days 00:24:19 – Psychedelics, meditation, and the search for transformation 00:24:51 – What the medicine always teaches: sit with yourself 00:25:03 – The wellness industry's tendency to monetize stillness 00:25:20 – Why you don't need expensive tools to transform 00:25:36 – Meditation as radical self-reclamation 00:26:02 – Meeting yourself without distraction 00:26:17 – Final reflections and closing thoughts 00:26:29 – Outro and farewell Thank You to Our Sponsors Alkemis: Go to https://alkemispaint.com/ and use code DARIN10 for 10% off your order. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Perhaps one of the most profound discoveries emerging from modern neuroscience is that many of the states of awareness humans have sought through substances, rituals, and external interventions may already be available within us. Meditation is not simply a relaxation practice—it appears to be a biological, neurological, and consciousness-altering intervention capable of reshaping the brain, changing the body, and transforming how we experience reality. The question is not whether the door exists. The question is whether we are willing to sit still long enough to walk through it." Bibliography/Sources: Here is the fully formatted bibliography for the "Seven Days to a New Brain" episode. It is organized by category, formatted in strict APA Style (7th Edition), and includes a direct link for every single source : Primary Studies Brewer, J. A., Worhunsky, P. D., Gray, J. R., Tang, Y. Y., Weber, J., & Kober, H. (2011). Meditation experience is associated with differences in default mode network activity and connectivity. Proceedings of the National Academy of Sciences, 108(50), 20254–20259 . https://doi.org/10.1073/pnas.1112029108 Lieberman, J. M., Rahrig, H., Britton, W. B., et al. (2025). Toward a neuroscience of consciousness using advanced meditation. Neuroscience & Biobehavioral Reviews . https://meditation.mgh.harvard.edu/files/Lieberman_25_NeuroscienceAndBiobehavioralReviews.pdf Pascarella, A., Jerbi, K., et al. (2026). Meditation induces shifts in neural oscillations, brain complexity, and critical dynamics: Novel insights from MEG. Neuroscience of Consciousness . https://pubmed.ncbi.nlm.nih.gov/41287816/ Patel, H., et al. (2025). Intensive meditation retreat induces rapid changes in brain activity, blood-based biomarkers, and neurotrophic signaling. Communications Biology . https://today.ucsd.edu/story/meditation-retreat-rapidly-reprograms-body-and-mind Shinozuka, K., et al. (2025). Neuroelectrophysiological correlates of extended cessation of consciousness in advanced meditation [Preprint]. bioRxiv . https://meditation.mgh.harvard.edu/files/Shinozuka_25_bioRxiv.pdf Van Lutterveld, R., et al. (2025). An intensively sampled electroencephalography case study of advanced concentration absorption meditation (jhana) [Preprint]. SSRN . https://meditation.mgh.harvard.edu/files/VanLutterveld_25_SSRN.pdf Supporting Press Coverage & Explainers Harvard Gazette. (2026, January). Your brain on advanced meditation . https://news.harvard.edu/gazette/story/2026/01/your-brain-on-advanced-meditation/ Medical Xpress. (2026, February). Study of 12 monks finds meditation heightens brain activity, reshaping neural dynamics . https://medicalxpress.com/news/2026-02-monks-meditation-heightens-brain-reshaping.html PsyPost. (2026). Brain scans of Buddhist monks reveal how different meditation styles alter consciousness . https://www.psypost.org/brain-scans-of-buddhist-monks-reveal-how-different-meditation-styles-alter-consciousness/ ScienceDaily. (2026, April 6). Scientists say 7 days of meditation can rewire your brain . https://www.sciencedaily.com/releases/2026/04/260406192913.htm UC San Diego Today. (2026). Meditation retreat rapidly reprograms body and mind. UC San Diego News Center . https://today.ucsd.edu/story/meditation-retreat-rapidly-reprograms-body-and-mind Université de Montréal. (2026, January 5). Meditation doesn't rest the brain, it reshapes it. UdeMNouvelles . https://nouvelles.umontreal.ca/en/article/2026/01/05/meditation-doesn-t-rest-the-brain-it-reshapes-it