SciPod

Research from Professor Rumi Kato Price at the Washington University School of Medicine and her colleagues, Professors Sheldon Zhang and Annah Bender, reveals how research-driven, standardized indicator approaches can better identify human trafficking victims than traditional legal and prosecutorial frameworks. Their work in Cape Town, South Africa demonstrates that trafficking victimization exists on a spectrum rather than as a binary classification, with implications for improving identification and support for victims worldwide.

Research from Professor Germaine A. Hoston at the University of California, San Diego, reveals how traditional Chinese philosophical idealism influenced the development of Chinese Marxism. Her findings demonstrate that despite their rejection of China's feudal past, key Chinese Marxist theorists like Li Dazhao and Mao Zedong incorporated elements of Neo-Confucian idealism into their revolutionary philosophy. This "sinification" of Marxism drew particularly on concepts of consciousness, will, and the unity of knowledge and action from traditional Chinese thought, creating a uniquely Chinese revolutionary philosophy that challenged Soviet economic determinism.

Sitting directly over a complex network of fault lines, Haiti is one of the most earthquake-prone nations on Earth. In 2021, the Nippes earthquake became the latest to devastate the country, and today, researchers are still piecing together the timeline of seismic events which unfolded during the earthquake. Through their research, Professor Jeremy Maurer and colleagues at Missouri University of Science and Technology have described how the Nippes earthquake originated, shifted, and ruptured a major fault line, triggering numerous ‘afterslip' events in the following days.

Research from Professors Tristan Nighswander and Ariel Roddy at Northern Arizona University examines the effects of pre-employment training on employment outcomes for previously incarcerated individuals through the lens of two economic theories. Their findings reveal that while training significantly improves employment outcomes for the general population, it shows no meaningful benefit for those with incarceration histories. Even more surprisingly, high-ability individuals (defined through scores on an aptitude test called the Armed Forces Qualification Test, or the AFQT) with past incarceration may actually experience negative employment effects. This highlights the complex challenges of societal re-entry.

We can imagine our health as a jigsaw, with each individual piece representing a different aspect of our medical history. These pieces might include blood test results, X-ray images or the notes taken by a doctor as we describe our symptoms. These jigsaw pieces are ultimately recorded and stored in electronic health records (or EHRs). EHRs are a valuable resource, providing an overview of someone's health and they could have the potential to allow clinicians and researchers to unlock new medical insights. However, there's a fly in the ointment - not all the pieces in such records always fit together correctly, and they may not completely capture the required information. Some clinical event documentation may not be complete, others do not align with related pieces, and some events are even missing entirely. This data quality problem was tackled by Dr. Hanieh Razzaghi of the Children's Hospital of Philadelphia, and her colleagues, in their innovative work on the PRESERVE study, a research project exploring chronic kidney disease in children (the PRESERVE study itself was led by Drs. Michelle Denburg and Christopher Forrest). Using EHRs from 15 different hospitals across the United States, the team aimed to understand how various treatments could potentially slow down chronic kidney disease progression. However, initially, they had to make sure that the data they were relying on were accurate, reliable, and suitable for the required complex analyses.

Associate Professor Yassir Mahgoub and his team at Penn State University have uncovered an important link between melancholia – a severe form of depression that often doesn't respond to treatment – and catatonia – a condition characterized by abnormal movements and associated with schizophrenia. The researchers analyzed case studies involving six patients who had been hospitalized for severe depression. All six patients experienced significant relief from their depressive symptoms by taking lorazepam – a drug typically used to treat catatonia. This discovery reveals a potential new avenue for treating severe, treatment-resistant depression.

Our gut contains a sleepless army, creating a hostile environment for pathogens, and helping to fortify our body's immune defences. It may surprise you to learn that this army isn't even human in nature, but is bacterial. The trillions of bacteria that naturally live in our gut, known as the gut microbiota, form an important component of our overall immunity against infectious disease. While bacteria can also cause disease, beneficial bacteria naturally colonise available spaces in our body, such as the gut, and play a key role in our immunity and physiology. Research conducted by Prof. Nelson Gekara of Stockholm University in Sweden and colleagues has revealed that these microscopic organisms play a crucial role in protecting us from viral infections, even in organs that are unconnected to the gut. Their study, published in the journal Immunity, uncovers a fascinating link between the gut microbiota and our body's ability to fight viruses, offering new insights into immune function and the unintended consequences of antibiotic use.

A recent paper from Professor William Gardner at Texas Tech University and Professor Kelly Davis McCauley at West Texas A&M University challenges a critique that characterized authentic leadership theory as “wrong” and "perilous." Their analysis demonstrates how misrepresentations of the theory can undermine valuable leadership approaches, while highlighting the empirical support and practical benefits of leaders striving for authenticity in organizational settings.

Cancer is a daunting healthcare challenge, and is still affecting millions worldwide, despite the enormous research resources that have been directed at finding effective treatments over the past decades. Many anti-cancer treatments remain poorly specific for the tumours they are intended to treat, and often suffer from modest efficacy and serious off-target effects. Part of the problem is the inherent variability between many tumours and their resulting unpredictable responses to standard chemotherapy. However, the latest advancements in precision oncology may be the start of a new paradigm, potentially providing targeted therapeutic payloads that can successfully address the specific and unique issues underlying a given patient's cancer. Researchers such as Prof. Diana Jaalouk and her colleagues at the American University of Beirut in Lebanon are pioneering innovative tools that are changing the way we understand and treat this complex disease. Two remarkable recent technologies, CRISPR-Cas9 and PROteolysis TArgeting Chimeras (or PROTACs for short), are at the forefront of this precision revolution. While distinct in their approach, these tools share a common goal: targeting cancer with precision and minimizing harm to healthy cells. Together, they are set to reshape the therapeutic landscape.

When most of us think about poultry, our minds often turn to chickens, the staple of farms and dinner tables worldwide. However, Nigeria is home to several other fascinating types of poultry beyond the humble chicken that have played significant roles in the country's agriculture, culture, and economy. While these poultry species are firmly embedded in the Nigerian agricultural system, the history of how and when these animals came to be domesticated and where these populations originally derived from is often obscure. Recent research conducted by Dr. Adeniyi Charles Adeola of the Chinese Academy of Sciences, and colleagues, has shed new light on three often-overlooked poultry species, the Muscovy duck, the domestic pigeon, and the helmeted guinea fowl. These birds not only offer valuable genetic resources but also hold keys to food security, sustainable farming, and biodiversity conservation.

Research from Dr Christopher W. B. Stephens and Sue Miller at the Susanna Wesley Foundation, Southlands College, Roehampton, reveals how university chaplains can effectively evaluate and demonstrate their impact within higher education institutions. Their work shows how chaplains can meet institutional demands for accountability while maintaining the unique spiritual and pastoral nature of their work, offering insights into evaluating the distinctive aspects of chaplaincy services.

In recent years, natural products such as kratom, which derives from a Southeast Asian tree called Mitragyna speciosa, and cannabidiol (or CBD) which derives from the Cannabis plant, have gained significant popularity for their potential to relieve anxiety, manage pain, and enhance mood. While both substances are often praised by users for their plant-based origins, and are often considered safer than synthetic pharmaceuticals as a result, the scientific community is working to uncover the complexities behind how these compounds interact, not just with the human body but with each other. After all, plant-based compounds are still active, and have the same potential for benefit and harm as any drug. People who use kratom are also more likely to use CBD, meaning that they could potentially experience a drug interaction if both substances are ingested around the same time. A recent study by Dr. Erin Berthold and her colleagues at the University of Florida sheds new light on the pharmacokinetic interactions between kratom and CBD, revealing findings that are both fascinating and important for public health.

We think of our brains as safe and secure within our skulls, and not easily influenced unless we consume a mind-altering substance, suffer a traumatic injury or undergo invasive brain surgery. However, recent research shows that our brain activity can be influenced non-invasively using nothing but sound and that this technique could have therapeutic potential. As a postdoctoral researcher at UC Berkeley, Dr. Ben Sorum began to think about these types of question while in the Lab of Dr. Stephen G. Brohawn. Now, Dr. Sorum's current research at Cooper Medical School of Rowan University explores how ultrasound, which can be non-invasively administered from outside the brain and through the skull, can activate specialized proteins in brain cells, changing their activity. The technique, if further developed, may play a key role in the future of neuromodulation, a field with enormous potential for treating neurological disorders.

In recent years, plant-based diets have gained significant traction, not just among vegetarians and vegans but also among individuals looking to improve their health and reduce their environmental impact. Increasing public awareness of the role of animal food production in driving climate change, along with the potential health risks of consuming large amounts of animal foods has powered this phenomenon. However, one of the ongoing debates in nutrition revolves around protein, a crucial nutritional component, and the nutritional quality of various protein sources. Can plant-based protein sources provide sufficient, high-quality protein compared with animal-based protein sources in the context of a dietary pattern? The question relates to consumer awareness and education, as not all plant proteins are created equal, and replacing meat, diary, and other animal proteins with just one or two plant protein sources may not provide everything we need nutritionally. Rather, a mix of plant protein sources may be required as an adequate replacement for high quality animal protein. As consumers increasingly replace animal proteins with plant proteins, potentially without awareness of these issues, is the overall quality of the protein they are consuming decreasing? Dr. Christopher Marinangeli of Protein Industries Canada and his colleagues set out to answer this question in their research on the effects of increasing plant protein intake on protein quality and nutrient consumption among U.S. adults.

Words change their meanings over time, but tracking these changes has traditionally required painstaking manual analysis by linguists. In recent years, researchers have been using computational models to automatically detect when semantic change happens, and how much of a change has occurred. Recent research led by Associate Professor Nina Tahmasebi and her colleagues in the Change is Key! program introduces innovative computational methods for detecting qualitative features of semantic change, opening new possibilities for understanding language evolution at scale.

Performing at your best when it matters most is something a lot of people struggle with. You can prepare for days, even weeks, but the moment you step on stage, walk into an interview, or face a big audience, things shift. Suddenly, what felt solid in practice starts to slip. I'm Dr. Oksana Komarenko. I teach at Ball State University, and I'm also an opera singer. I know what it's like to face high-pressure moments. During my first major solo recital, my hands started shaking so badly I could barely control them. Everything I had rehearsed felt just out of reach. And I'm not the only one. Research shows that over 77 percent of performers experience the same thing when the pressure is on.

Recent research from Professor Maryam Mehrnezhad at the Information Security Department, Royal Holloway University of London and a team of researchers reveals widespread privacy, security and regulatory failings in female-oriented health technologies (also known as FemTech). The researchers' comprehensive analysis demonstrates how current practices leave sensitive health information vulnerable, while highlighting an urgent need for reform across technical, legal and social dimensions of digital healthcare.

The African turquoise killifish, also called Nothobranchius furzeri, is a small, vibrant freshwater species that is making a big splash in aging research. With our aging populations, research into aging and the mechanisms underlying age-related health issues is increasingly important. Scientists in this valuable field prize the killifish because it has a significantly short lifespan at just six to twelve months, making it an ideal model to study age-related diseases. However, as research on this species grows, so does the need for better care and monitoring of their health. In fact, distinguishing between the natural effects of aging and other health issues in these fish, such as pathogens or disease, is crucial in accurately researching age-related phenomena. Moreover, identifying health issues in laboratory fish could help researchers to better maintain health in their fish stocks, improving both experimental results and animal welfare. This is where Dr. Beate Hoppe and her colleagues at the Leibniz Institute on Aging at the Fritz Lipmann Institute, Jena, Germany, step in, pioneering a comprehensive approach to monitoring and managing killifish health that could revolutionize laboratory fish research.

Employers and other decision makers typically use interviews to make their final decision on candidates applying for important positions. The process begins by reviewing resumes, and checking references, before the final and typically most important act, the interview. Within mere minutes, an interviewer can form a strong impression of a candidate. For instance, this may run along the lines of “this person seems confident, articulate, and driven” or “this person does not represent themselves well, and likely won't be a good fit”. By the end, the interviewer may feel that they truly understand the candidate. But what if that feeling is just an illusion? This is the question tackled by Prof. Jason Dana of Yale University and his colleagues in their research on unstructured interviews. Their findings challenge one of the most common hiring and admissions practices: the belief that sitting down with a candidate and having a free-flowing conversation reveals valuable insight. In reality, their study suggests that unstructured interviews often do more harm than good, leading decision-makers to rely on misleading impressions rather than objective facts.

Colorectal cancer is a significant health challenge, and ranks as the second leading cause of cancer-related death and the third most common type of cancer in the United States, among men and women combined. Each year, over 52,000 people in the U.S. die from colorectal cancer, with more than 5,300 deaths occurring in California alone. While early detection of colorectal cancer through screening can significantly reduce both its incidence and mortality, ensuring that screening programs remain effective and sustainable is no small feat, particularly in the face of uncertain funding. This pressing issue is at the heart of recent research conducted by Dr. Ndukaku Omelu of the California Department of Public Health, and colleagues, who examined the sustainability of colorectal cancer screening strategies implemented through the California Colon Cancer Control Program (or C4P for short), with a particular focus on how these screening programs would fare in the absence of future C4P funding, a program funded by the Centers for Disease Control and Prevention (or CDC for short).

In order to operate safely and efficiently, lithium-ion batteries rely on battery management systems to monitor their state and to control their operation. An essential part of this process is modelling battery behaviour under different conditions to predict performance and prevent failures. To do this efficiently, it is crucial to simplify the underlying physical processes, while sacrificing as little accuracy as possible. Through their research, Dr. Luc Raijmakers and colleagues at the Jülich Research Centre, Germany, compare various different approaches to simplifying simulations. Their results could make it easier for battery operators to decide which approach is best suited to their requirements for accuracy and computational efficiency.

Research by Professor Joanne Wood at the University of Waterloo reveals how self-esteem influences romantic relationships through a chain of psychological and behavioral effects. Their work challenges simple explanations and demonstrates how one partner's self-worth can create ripple effects that impact both partners' relationship satisfaction.

Research by Professor Denise Troutman at Michigan State University examines how race, gender, and social context shape perceptions of politeness and impoliteness in language, particularly focusing on the term 'sassy' when applied to African American women and girls. The research challenges traditional theories of politeness and reveals a need for cultural contextualizations to avert harmful stereotypes.

Friction is no fun, and moving our joints freely and without pain requires that it is minimised as much as possible. Cartilage is the cushiony, slippery and translucent tissue that lines the ends of our long bones and acts as a lubricating layer within our joints to make their movements smooth and effortless, or at least that's the theory. For millions of people, ease of joint movement is painfully disrupted by osteoarthritis, a condition that gradually and progressively erodes this protective and functional cartilage layer and leads to pain, stiffness, and reduced mobility. No fun at all. The work of Dr. Marina Danalache of the Department of Orthopedic Surgery at the University Hospital of Tübingen, Germany, and her colleagues sheds new light on how this cartilage breakdown begins and proceeds. Meet matrix metalloproteinase enzymes (or MMPs for short): master regulators of cartilage remodelling, balancing renewal and destruction. In osteoarthritis, this equilibrium shifts - the researchers are decoding their precise roles aiming to unlock targeted interventions and transformative therapies.

Each year, thousands of Australians undergo a procedure to have a cardiac device implanted. These devices, such as pacemakers and defibrillators, help to regulate the heartbeat. Such cardiac implantable electronic devices (or CIEDs for short) are vital for many patients, ensuring that their hearts function properly and preventing life-threatening conditions. However, as Professor William Heddle of Flinders University, Adelaide, Australia, a leading expert in cardiology, points out in a recent Editorial article in the Medical Journal of Australia, these procedures are not without risks, particularly the risk of infection. Prof. Heddle's Editorial primarily focuses on a recent study conducted in New South Wales, Australia, which sheds light on the factors that increase the risk of CIED-related infections and offers insights into how these risks can be minimized.

Pollinators, including honey bees, wild bees, butterflies and many other insects, are some of the most important creatures on our planet. By pollinating plants, both wild and cultivated, they have an essential role in maintaining wider ecosystems and ensuring our food security. However, we have come to take them for granted, and don't fully appreciate their function in ensuring our ongoing survival. Insects are declining at a truly alarming rate. Among other factors human activities such as industrial farming and corresponding insecticide and fungicide use over large areas of land to protect food crops against pests and disease are considered to be major contributors. Many different pesticides have also been detected in honeybee colonies. Scientists are attempting to uncover the specific factors involved in insect decline, before it's too late. Recent research by Sarah Manzer and colleagues in the research groups of Prof. Ricarda Scheiner and Prof. Ingolf Steffan-Dewenter at the Julius Maximilians Universität Würzburg in Germany has shed new light on a potential culprit: a combination of insecticides and fungicides commonly used in agriculture.

Before the universe was illuminated by stars, most of its observable matter existed in a roughly even distribution of hydrogen and helium. As these materials collapsed under their own gravity, they would have heated up, initially preventing them from collapsing further to densities high enough for stars to form. As part of a new review, Prof. Dr. Ralf Klessen and Prof. Dr. Simon Glover at Heidelberg University investigate the chemical mechanisms which enabled this primordial gas to cool and fragment to form the universe's first generation of stars.

Research from Professor Carsten Herrmann-Pillath at the University of Erfurt and Professor Guo Man at Harbin Institute of Technology Shenzhen Campus reveals how traditional funeral practices are being transformed in Shenzhen, an area of China which has rapidly developed into a huge metropolis. The research shows how government regulations, economic forces, and cultural traditions interact to create new forms of death rituals that balance modern urban constraints with deep-rooted customs.

The Sichuan basin in southern China is a region of deep geological and seismological complexity, which has so far prevented researchers from understanding its tectonic past. Through fresh analysis of previous observations, combined with the latest modelling techniques, a team led by Dr. Zhe Su at the National Institute of Natural Hazards, Beijing, suggests for the first time that the entire Sichuan basin is slowly rotating. Their result could explain the origins of one of the deadliest earthquakes in living memory, and could also help seismologists to better predict when earthquakes will strike the region in the future.

Antibiotic resistance may prove to be one of the most significant health challenges we will face this century. As bacteria continue to evolve resistance mechanisms to our arsenal of antibiotics, infections could become a more serious prospect, and medical procedures with a substantial infection risk, such as open surgery, could become unacceptably risky. While antibiotic resistance is often considered to be a human problem, it's also a growing issue in veterinary medicine. Our pets can also develop infections that are difficult to treat when resistant bacteria are involved. Moreover, as we frequently share a living space with such animals, there is potential for crossover of resistant bacteria to humans. In a far-reaching study, Dr. Robin Temmerman and his colleagues of the executive animal health study center (or CEESA), which is a consortium of animal health companies, shed light on this issue, exploring antibiotic resistance in bacterial urinary tract infections in dogs and cats across Europe. Their findings provide hope and a roadmap for tackling this global problem.

Dr Patrick O'Neill of Pfizer, Ireland, and Professor Jie Wu of the National University of Singapore, and their team, have made groundbreaking advancements in the synthesis of 1,2,3-triazole – a key building block in the manufacture of a life-saving antibiotic. Replacing traditional batch processes, they developed a safer, more efficient method using continuous flow chemistry, which addresses potential global supply chain vulnerabilities. This innovative approach eliminates hazardous intermediates, improves reaction safety, and ensures a stable supply of 1,2,3-triazole for global pharmaceutical production.

For a long time, deformities of the chest wall, such as pectus excavatum, a condition where the chest appears to have sunken, remained untreated or were treated using crude and invasive techniques. However, thanks to innovations led by surgeons such as Prof. Donald Nuss of Eastern Virginia Medical School, these procedures have undergone a remarkable transformation. Such work has shifted the paradigm from radical surgery to minimally invasive solutions, changing lives and restoring confidence for countless patients. Now, a Review Article published in the African Journal of Thoracic and Critical Care Medicine, and co-authored by Prof. Donald Nuss and Dr. Ivan Schewitz of the Department of Cardiothoracic Surgery at the University of Pretoria, South Africa, charts the remarkable progress in treating pectus excavatum.

In many regions around the globe, common mental health issues are cloaked in secrecy by those who experience them, and are frequently stigmatized and misunderstood by others. This is a particularly serious issue in conservative communities, where cultural and religious values have significant effects on the provision and use of appropriate mental health care resources. In a new mini-review article published in the journal Frontiers in Public Health, Dr. Mabrouka Abuhmida, Dr. Wendy Booth and Dr. Felix Anyanwu of the University of South Wales in the UK, have explored this critical topic, revealing the damaging impact of stigma in such communities, and exploring new solutions to enable adequate mental healthcare in this context.

Research by Dr. Claudia Ituarte-Lima and Dr. Radu Mares at Lund University examines how a pioneering environmental agreement in Latin America and the Caribbean introduces new ways of protecting nature and human rights. Their study reveals both opportunities and challenges in how this regional treaty interacts with European Union trade laws, offering insights into how different regions can work together to protect the environment and strengthen democracy.

Research by Professor Will Greaves at the University of Victoria examines how the Trump presidency has impacted the long-standing security relationship between Canada and the United States. His analysis reveals concerning shifts in the foundations of bilateral cooperation and trust between these traditionally close allies, with implications for the future of North American security arrangements.

Imagine living with an illness that can sap your energy levels so completely that even day-to-day tasks, such as doing laundry, walking the dog, or even getting out of bed can be insurmountable challenges. To make matters worse, this illness is not well understood either by the public or by medical staff, and is often dismissed and stigmatised, making it difficult to find understanding or treatment. This is the unfortunate lived experience of many people with myalgic encephalomyelitis/chronic fatigue syndrome (or ME/CFS for short). In a recent Communication article, researcher Caroline Kingdon of the London School of Hygiene and Tropical Medicine, and colleagues, discuss this misunderstood condition through the prism of the 2021 guideline for the treatment of those with ME/CFS, which have been published by the UK's National Institute for Health and Care Excellence (or NICE for short). Their article aims to inform primary caregivers about the NICE guideline, and, happily, reveals that the new guideline prioritises an overdue shift toward compassionate and patient-focused care for ME/CFS.

Research by Dr. Anne Hultgren and colleagues at the Arnold and Mabel Beckman Foundation demonstrates that blinding reviewers to applicants' institutional affiliations (also known as dual-anonymous reviews) leads to more equitable distribution of research funding opportunities. Their study reveals how removing identifying information helps overcome unconscious biases toward prestigious universities in grant review processes.

Across the varied and diverse landscapes that make up the Nigerian countryside, animals, both wild and domesticated, are more than merely an agricultural commodity or source of food; they are an integral part of local cultures, natural biodiversity, and represent an ecological treasure trove. Local wildlife and agricultural livestock help to sustain the livelihoods of millions. However, beyond this, Nigerian animals hold secrets within their genetic code that could, when revealed, help to prevent diseases, aid conservation efforts and enhance agricultural productivity. Leading the efforts to uncover useful and interesting genetic phenomena in these animals is Dr. Adeniyi Charles Adeola of the Chinese Academy of Sciences, who explores the genetic blueprints of Nigerian animals in his pioneering research. From investigating the population dynamics of grasscutters to tackling the genetic roots of prion diseases, Dr. Adeniyi Charles Adeola's work illuminates both challenges and solutions that impact food security, agriculture, and biodiversity in Nigeria, and far beyond.

Research by Professor Magnus S. Magnusson at the University of Iceland demonstrates surprising similarities between the organization of cellular protein networks and of human societies. He reveals how the invention of writing and, very recently, general education, transformed human civilization in ways that mirror ancient biological developments and emphasises how this makes humans unique.

Sepsis is a critical illness that begins with a simple infection and degenerates into a severe and dysregulated immune response that affects the whole body. This significant immune reaction typically causes widespread inflammation and can progress very rapidly. This can result in serious damage to tissues and organs, potentially leading to organ failure and death. Despite the severity of sepsis and its frequent poor prognosis, effective treatments are still elusive, and many sepsis patients remain at high risk of death and serious complications. Part of the issue is the complex cascade of cellular and biochemical events that underlie sepsis, which has made it difficult to obtain a comprehensive overview of the illness from which to design an effective treatment. Dr. Roberta Martinelli, Executive Director of Stromal Immunology and Early Discovery, Discovery Immunology, Merck, and colleagues, have published a study in the journal iScience which reveals new insights into the complex biological milieu underlying sepsis, and uncovers pathways and potential treatment targets that could change how we diagnose and treat this life-threatening illness.

Research by Professors Bernd Schlipphak and Oliver Treib, both of the University of Münster, along with Doctor Constantin Schäfer of ifok GmbH, Germany, reveals how people's sense of global identity influences their support for international organizations. Their work demonstrates that reforms to international organizations can have opposing effects on different groups of citizens, potentially increasing societal divisions about global cooperation.

The oceans, huge and brimming with diverse lifeforms, pose no less a struggle for survival for their inhabitants than that faced by creatures on dry land. Evolution has furnished marine organisms with huge array of defensive, and indeed, offensive adaptations to help them to thrive in this battleground. Among the organisms who live and compete in the ocean are dinoflagellates. These are small, single-celled creatures that are an important component of plankton found in marine ecosystems. Despite their tiny size, dinoflagellates such as Karlodinium veneficum can wield potent biochemical weaponry that gives them an edge against other competing organisms. Decades since the discovery of the toxic properties of Karlodinium veneficum, researchers such as Dr. Allen Place of the University of Maryland Center for Environmental Sciences, and his colleagues, have begun to unravel the secrets of its potent toxins, called karlotoxins. Their findings offer fascinating insights into the interactions of marine life and the weapons they adopt to capture prey and deter predators.

It's not difficult to picture a lush forest landscape populated with majestic deer and elk, long admired for their prowess and strength. Now, imagine that same scene, but instead of healthy and happy animals browsing a forest ecosystem, we see creatures that are thin and disoriented, that struggle to run or even stand, with halting and confused movements that are pitiable and distressing to watch. This is the harsh reality of Chronic Wasting Disease, an illness that currently has no cure and that threatens such wildlife around the world. Part of the challenge with Chronic Wasting Disease is the difficulty in studying it reliably in wildlife. The disease has subtle signs at an early stage, and it is difficult to obtain robust and reproducible data from large, wild animals who often live in remote and poorly accessible forest ecosystems. Consequently, researchers have turned to an unlikely but powerful ally, the tiny laboratory mouse, to model and study the disease under laboratory conditions. Dr. Andrea Grindeland of the McLaughlin Research Institute, and her colleagues, have authored a review of the existing mouse models of Chronic Wasting Disease. These tiny creatures have been engineered to mimic the biology of cervids, such as deer and elk, and are providing crucial insights into how Chronic Wasting Disease evolves, is transmitted, and how it might one day be controlled or even eradicated.

Racist encounters, both subtle and overt, continue to plague society and take a severe toll on the mental and physical health of people of colour. However, innovative research shows how we can equip youth and adults with the skills to navigate these stressful situations and emerge stronger. Dr. Howard Stevenson and his team at the University of Pennsylvania are pioneering new approaches to help people cope with racial trauma and find their voice.

The Arctic's climate is changing faster than almost anywhere else on Earth, but climate scientists are still uncertain how it is being affected by carbon-rich aerosols, released by fires thousands of kilometres to the south. Through their research, a team led by Dr Yvette Gramlich at Stockholm University in Sweden and the Paul Scherrer Institute in Switzerland has gained deeper insights into how these aerosols are impacting Earth's northernmost reaches. Their work could help climate scientists to better predict how the Arctic's climate will change in the future.

Cholangiocarcinoma is an aggressive cancer that begins in the bile ducts. While the cancer is relatively rare, affecting approximately 8,000 people in the United States each year, unfortunately, it is often undiagnosed until an advanced stage. This late diagnosis makes cholangiocarcinoma very challenging to treat, and less than 10% of patients survive for five years after diagnosis. Traditional anti-cancer treatments, such as chemotherapy, have only limited effectiveness in cholangiocarcinoma, and can cause serious side effects. Recently developed immunotherapy and targeted therapies have provided promising options for this difficult-to-treat disease. Dr. Kim Saverno of the Incyte Corporation, a biopharmaceutical company headquartered in the U.S., and the study's co-authors, have been studying the real-world use of an FDA-approved targeted drug for cholangiocarcinoma called pemigatinib. Pemigatinib was approved by the FDA in 2020. It can be specifically used for cholangiocarcinoma patients who have genetic changes in a protein known as fibroblast growth factor receptor 2, or FGFR2 for short. Their study, to the best of our knowledge, is the first to examine pemigatinib's use in real-world settings, and reveals information about treatment patterns, FGFR2 testing patterns, and effectiveness of pemigatinib for cholangiocarcinoma when used in everyday practice.

Hypertrophic cardiomyopathy (or HCM for short) is a serious heart condition that involves thickening of the heart muscle wall and disruption of the normal tissue architecture, called ‘disarray'. This can result in sudden cardiac death caused by abnormal heart rhythms, known as arrhythmias. Identifying those HCM patients who are most at risk could permit preventative measures, such as implanting a cardioverter-defibrillator, which could potentially be lifesaving. However, current techniques to predict the risk of sudden death in HCM are limited, leaving patients underserved. In a recent study, Dr Richard Saumarez, an academic cardiologist formerly of the University of Cambridge, and colleagues, questioned whether conventional methods, which consider risk factors such as family history of sudden death or the degree of heart muscle thickening, are effective in predicting sudden death in HCM patients. Their research suggests that risk factor assessments might miss crucial information about the heart's electrical behaviour, which could provide more accurate clues about the risk of sudden death. As an alternative, the researchers propose direct heart-investigation methods, called electrophysiological techniques, as a more reliable assessment. Although the study was concerned with HCM, the arguments put forward are more general and applicable to other diseases, particularly to survivors of myocardial infarcts who are also at risk of sudden death.

Our hearing is amongst our most profound senses, connecting us to the surrounding world through sound. However, this connection is diminished or absent altogether in millions of people around the world because of hearing loss. Hearing loss is a common sensory disorder and is often hereditary. The condition can be caused by complex genetic factors, and so far, researchers have linked over 150 genes to hearing impairment. Now, a new collaborative study led by Dr. Qiang Wang of the South China University of Technology, Dr. Tao Cai from the National Institute of Health, and Dr. Yuan Li from the China-Japan Friendship Hospital in Beijing, has uncovered a new genetic clue, a mutation in the OXR1 gene, that could upend our understanding of hereditary hearing loss, and the eventual treatments that we develop to combat it.

Humans aren't the only species that use tools, many animals do. Our closest relatives, the great apes, have long been known for their intelligence and ability to manipulate objects in their environment. Among the great apes, orangutans stand out for their complex tool use, which may hold important clues about how early human technologies evolved. A recent Outlook article authored by Dr. Robert Shumaker and Dr. Christopher Martin, both of the Indianapolis Zoo, delves into the existing research into ways that orangutans use stone tools, exploring the cognitive processes behind this behavior and what it can tell us about human evolution.

As global agriculture faces increasing challenges from climate change, soil degradation, and herbicide resistance, sustainable practices are becoming more crucial than ever. Among these practices, the use of cover crops, a technique that has been gaining traction for its multiple benefits, stands out. Dr. Kurt Vollmer and his colleagues at the University of Maryland and Rutgers University have delved into this area, focusing on the potential of spring-seeded grass cover crops in improving weed management and crop yields, specifically in cucurbit production. Their research sheds light on how integrating cover crops with traditional farming techniques can lead to more sustainable and productive agricultural systems.

Neuromorphic computing is a powerful tool for identifying time-varying patterns, but is often less effective than some AI-based techniques for more complex tasks. Researchers at the iCAS Lab directed by Ramtin Zand at the University of South Carolina, work on an NSF CAREER project to show how the capabilities of neuromorphic systems could be improved by blending them with specialized machine learning systems, without sacrificing their impressive energy efficiency. Using their approach, the team aims to show how the gestures of American Sign Language could be instantly translated into written and spoken language.