SciPod

Research from Dr. Andrey Kostyuk at the Grenoble Ecole de Management supervised by Prof. Martina Battisti, a Senior Fellow of Higher Education Academy, and Director of European Council for Small Business and Entrepreneurship, reveals that successful startup mentoring operates as a complex social exchange where both mentors and entrepreneurs must benefit for ventures to thrive. The findings advance the understanding of entrepreneurial mentoring and provide a blueprint for designing more effective mentoring programs that could accelerate sustainable startup growth worldwide.

Despite decades of awareness about gender equality, a persistent pleasure gap remains between women and men in sexual encounters, with women experiencing significantly fewer orgasms and less sexual pleasure. It is important to note that this gender difference exists primarily in contexts where women have sex with men, while women who have sex with women tend to experience more orgasms and sexual pleasure. Since the gendered pleasure gap cannot be explained by biological factors, researchers continue investigating hidden sociocultural forces that perpetuate this inequality. Two complementary studies from Tanja Oschatz at Johannes Gutenberg University and her colleagues reveal previously overlooked contributors to this gap: women's performance of sexual emotional labor in intimate relationships and biased media representations of sexual pleasure.

Imagine a future where treating cancer doesn't just depend on high-tech machines or potent drugs, but also on something as simple, and as complex, as the bacteria living in your gut. This future might be closer than we think, thanks to groundbreaking research led by Professor Andrea Facciabene at the University of Pennsylvania. In a randomized pilot study recently published in the Journal for ImmunoTherapy of Cancer, Prof. Facciabene and an international team of researchers explored a curious and compelling idea: could altering the gut microbiome enhance the effectiveness of radiation therapy in patients with inoperable early-stage lung cancer? The answer, at least in this early stage, appears to be yes.

Research from communication scholars at The Ohio State University reveals fascinating new insights about the dynamics of conversations about race-related issues in the USA. Two complementary studies show that White participants expected more negative outcomes and were more likely to avoid conversations with fellow White people from different political parties than with Black people from different parties. The findings challenge assumptions about racial identity and suggest that partisan divisions have become more influential than racial divisions in shaping willingness to engage in difficult conversations.

When they design mechanical systems, engineers first need to understand how they will behave using mathematical modelling tools that can simulate their movements. In recent years, they have increasingly explored the possibilities of ‘compliant' mechanisms: highly flexible systems which are now being applied across numerous leading fields of technology. However, because their motions are often incredibly complex, engineers have so far found it difficult to recreate their behaviours in the mathematical tools needed to design them. Because they involve complex, nonlinear behaviour, designing compliant mechanisms has posed a long-standing challenge for engineers. While several advanced synthesis methods are now available, they're often computationally intensive and can't readily cope with the inevitable uncertainties in a system's operating variables. In their latest research, Ahmed Alhindi and Dr. Meng-Sang Chew at Lehigh University, Pennsylvania, propose a novel approach that directly accounts for uncertainty in the design process. By reformulating widely used equations, their ‘dimensional synthesis' method offers a streamlined yet powerful way to design compliant mechanisms under real-world, uncertain conditions.

Loneliness is often described as the invisible epidemic of our time. It creeps quietly into lives, eroding confidence, weakening social bonds, and, at its most dangerous, pushing individuals toward the edge of despair. Stigma can prevent the lonely from seeking help and as loneliness is largely experienced through the prism of isolation, those in need of support may feel they have no-one to turn to. In his chapter “Loneliness, Social Isolation, and Suicidal Behavior: ‘Only Girl, Middle Child'” from the Edited Volume “Loneliness - The Ultimate Suffering in Modern Society”, Dr. Raymond Atwebembere of the Washington University in St. Louis examines this crisis not through abstract statistics alone but through vivid personal stories. His work underscores the truth that loneliness is not just a feeling; if left unaddressed it can be lethal.

Operating and maintaining highway rest areas across the United States has long posed a costly challenge for state transportation departments, especially amid tightening budgets and rising demand. In a new study, Dr. Kishor Shrestha, associate professor at Washington State University finds that one outsourcing method known as method-based contracting is significantly more cost-effective than its two main alternatives. The results offer transport officials a clearer path forward for running rest areas more efficiently, and could help to preventing costly, potentially dangerous closures in the future.

Between 1982 and 2012, the 150-foot solar tower at Mount Wilson Observatory collected a vast archive of observations of the Sun's surface. In a series of recent studies, Professor Roger Ulrich, together with colleagues Dr. Tham Tran and Dr. John Boyden at UCLA, have revisited these data, running a thorough recalibration of the findings. Their results led them to a crucial discovery: two properties of the Sun's plasma which were once thought to be separate are actually two faces of the same underlying effect, which plays a fundamental role in shaping the Sun's magnetic field throughout the solar cycle.

In this episode, Professor Mary Rezk-Hanna of UCLA explores how flavored tobacco and nicotine products hook young people, challenge regulation, and blur the line between risk and appeal. Tune in to understand what's really at stake for public health.

By all measures, America's mental health system is stretched too thin. Families are in crisis, community mental health providers are overworked, and groundbreaking research often struggles to find its way into real-world practice. But thanks to researchers such as Professor Ukamaka Oruche of the University of South Florida, and colleagues, we're learning how to map and close that gap, one challenge at a time. When we think of medical breakthroughs or scientific discoveries, we often imagine white coats, high-tech labs, and swift translation from theory to practice. But in the world of mental health, particularly in community settings that serve the most vulnerable, reality looks very different. Shockingly, it can take 17 to 20 years for evidence-based mental health interventions to become part of everyday clinical care.

Building the next generation of particle accelerators depends on solving surprisingly small but stubborn material-related problems. Dr Jerzy Lorkiewicz and his collaborators of the National Centre for Nuclear Research in Poland tackled one of the toughest challenges: how to make lead films stick firmly to niobium, to realise his vision of a fully superconducting electron injector. By implanting lead ions into the niobium before adding a lead layer, his team created a smoother, more durable bond that resisted peeling. This innovation brings us closer to more efficient electron injectors for powerful particle accelerators.

Highly polar pesticides such as glyphosate are notoriously difficult to detect in food due to their chemical properties and interference from natural food compounds. A new method developed by Dr Michelangelo Anastassiades and Ann‑Kathrin Schäfer of CVUA Stuttgart, and their colleagues, offers a more accurate and practical way to identify residues of these pesticides. By simplifying sample preparation and reducing interference, the method delivers reliable results across a wide range of foods. This development improves routine food safety testing and strengthens our ability to monitor potentially harmful pesticides.

If you stroll into a McDonald's fast-food restaurant in Paris, Tokyo, or New York, you'll notice that the Big Mac tastes the same, the menu looks familiar, and the process is quick and efficient. You order your food, wait a short while, and you get exactly what you expect. In the 1990s, American sociologist George Ritzer gave a name to this phenomenon: McDonaldization. He identified four principles behind the model's success. The first is Efficiency, in terms of getting things done in the fastest, least expensive way possible. Second comes Calculability, which involves valuing numerical metrics, such as how many burgers sold and how fast they were served, over subjective qualities such as taste or ambiance. The third factor is Predictability, which involves making sure the experience is the same way everywhere. The final aspect is Control, where the corporation uses refined rules, technology, and systems to achieve the preceding three principles. While these ideas may work for burgers and fries, can they work if applied to something very different, such as healthcare? In a thought-provoking review, Professor Dr. Frederik Wenz of the University of Freiburg explores how these fast-food-inspired principles are transforming hospitals, clinics, and even the role of patients themselves. This phenomenon doesn't just involve faster patient registrations or standardized treatments. It's about a fundamental shift in how we think about healing, and how much responsibility patients are willing (or able) to take on themselves.

Research from Dr. Adam W. Carrico at the Florida International University, and his colleagues, explores innovative approaches to address HIV prevention and treatment challenges among sexual minority men who use stimulants. Three interconnected studies examine how behavioral interventions can reduce HIV viral load, alter gene expression in immune cells, and increase the use of preventive medication in this high-priority population. Collectively, these randomized controlled trials provide compelling evidence of the potential of behavioral interventions to improve health behaviors and outcomes.

When we reach into a medicine cabinet we aim to find something to relieve our symptoms and treat our ailments. This could be a painkiller for a headache, an antibiotic for an infection, or insulin for diabetes. Typically, we assume that what's inside that blister pack, bottle or vial is real, safe, and effective. But what if it's not, and not only may it be ineffective at relieving our symptoms, but it could even cause harm? That unsettling question is at the heart of a groundbreaking new study from the University of Plymouth. Led by Dr Maysa Falah and Dr Michael Dillon, the research team explored an underreported problem that quietly afflicts health systems worldwide: substandard and falsified medicines, or SF medicines for short. Through their research in Jordan, they offer a glimpse into how widespread and misunderstood the issue truly is, not just among the public, but also in pharmacies and clinics, revealing both the prevalence of poor-quality medicines and the deep uncertainty around what we trust to put in our bodies.

Research from Professor Juliane Reinecke at the University of Oxford and Professor Jimmy Donaghey at the University of South Australia reveals how strategic ambiguity in international agreements can paradoxically strengthen rather than weaken collective action. Their eight-year study of the Bangladesh Accord for Fire and Building Safety demonstrates how deliberately vague language that initially enables difficult negotiations can evolve into robust, expanding commitments that exceed original expectations.

Research from Dr. Bernhard Reinsberg at the University of Glasgow and Dr. Christoph Valentin Steinert at the University of Zurich reveals how France's groundbreaking mandatory due diligence law defied business predictions of economic harm. Through analysis of 11,504 French companies over fifteen years, their study demonstrates that requiring firms to monitor human rights and environmental standards in their supply chains had no significant impact on profitability. Their findings challenge widespread industry claims that such regulations threaten competitiveness and provide crucial evidence for policymakers considering similar legislation worldwide.

Training walls and entrance breakwaters have long been used to keep estuary entrances clear of shoals that threaten boat navigation and increase flood risks for nearby communities. But new research by Alexander Nielsen of Worley Consulting and coastal engineer Angus Gordon reveals that these structures may be causing long-term damage. Their study uncovers how engineered inlets are reshaping the flow of water through estuaries, disrupting wetland ecosystems and triggering costly maintenance challenges.

In the 18th century, Scottish philosopher David Hume posed a confounding question about the nature of the scientific method. By questioning the logic behind making predictions based on past observations, he exposed a fundamental problem that has vexed logicians to this day. But now, through a new analysis, philosophers Prof. Gerhard Schurz and Dr. Paul Thorn at Heinrich Heine University Düsseldorf offer a fresh perspective – one that could finally help us escape Hume's logical trap, through a concept known as regret-based meta-induction.

For over a century, Einstein's theory of general relativity has underpinned our understanding of gravity. However, it still hasn't been able to explain some of the most enduring mysteries in cosmology, including the need for vast quantities of dark matter, which has gone undetected for decades. Today, this need has been explained by Conformal Gravity: a framework which modifies Einstein's theory by requiring that the laws of physics must stay the same, even if all fields are scaled up or down at every point in space and time. Through his research, Robert Nesbet of IBM's Almaden Research Center argues that this principle – named ‘universal conformal symmetry' – should apply to all fundamental fields. If correct, this framework could eliminate the need for dark matter and dark energy.

We typically take our skulls for granted, beyond their basic function in keeping our brain safe and sound within our head. When you look in the mirror, the shape of your skull, which forms the very structure beneath your face, is something you may not have considered in much detail. However, the story of how your skull came to be, and how bone spread across your embryonic head in perfect symmetry to form a complete and protective dome over your brain, is a marvel of biology that scientists are only just beginning to understand. In a new study led by Dr. Jacqueline Tabler at the Max Planck Institute for Molecular Cell Biology and Genetics, researchers have uncovered a surprising and elegant mechanism behind how skull bones grow that is different to how we typically think of cell movement and migration in the body. Published in the open-access journal Nature Communications, this latest research rewrites what we thought we knew about cell movement, tissue development, and the mechanics of morphogenesis, the process through which an organism takes shape.

Communication research from Texas Christian University reveals how the killing of Atatiana Jefferson in Fort Worth exposed fundamental failures in how cities listen to Black residents. Through in-depth interviews and a national survey, Dr. Ashley English, Dr. Jacqueline Lambiase and Dr. Julie O'Neil demonstrate that meaningful organizational listening requires not just hearing community voices, but implementing changes based on their input. Their findings show that without authentic engagement and accountability, municipal listening processes perpetuate rather than disrupt systemic racism.

When a baby is born, the bones of the skull are meant to behave like the slats of a wooden barrel, flexible enough to slide into the correct orientation as the brain beneath them doubles in size during the first year of life. However, in about seven of every 100,000 births one of those seams between the bones of the skull (called a suture) closes too early along a single side of the forehead, a condition called unicoronal synostosis (or UCS). Instead of rounding out evenly, the skull twists: one brow pulls backward, the opposite brow juts forward, the eye sockets tilt, and the nose shifts off‑centre. Beyond cosmetic considerations such as the visible asymmetry, these children can also face raised brain pressure, vision problems and slower development.

When the COVID-19 pandemic arrived as an unexpected and unwelcome presence in our lives, it didn't just disrupt our daily routines, it drastically changed how we learn, teach, and connect. For many healthcare professionals, including those in dentistry, this meant abandoning lecture halls and clinical classrooms for an unfamiliar and potentially daunting virtual teaching landscape. After all, no-one knew if this mandatory experiment in online teaching would work out. Yet from this unprecedented upheaval emerged an extraordinary opportunity to rethink how education is delivered globally, one that Dr. Shasha Cui of the Eastman Institute for Oral Health at the University of Rochester School of Medicine and Dentistry, and her colleagues, seized with insight, innovation, and a keen eye toward the future.

By now, most of us are familiar with stories of wildlife interacting with the modern world, often with unfortunate consequences. Examples include urban foxes struck by vehicles, bears rummaging through trash, and sea turtles entangled in plastic. But there's a quieter, often unseen danger that claims hundreds of millions of bird lives each year. This is the common window, a source of light for us, but potentially deadly for unsuspecting birds on the wing. Bird-window collisions (or BWCs for short) are a global phenomenon and a growing conservation concern. Birds in flight often fail to perceive clear or reflective glass as a barrier, leading to fatal crashes into windows, especially on modern buildings. Until recently, tracking the scope of this problem, especially in tropical and subtropical regions, has proven difficult. Traditional monitoring methods require trained observers, time-consuming surveys, and, critically, access to fresh bird carcasses, which can vanish quickly in warm, scavenger-rich environments. But in Taiwan, an innovative approach is offering new hope, and it's coming from an unexpected place: social media.

When you imagine a scientific conference, you may picture rows of poster boards, bustling coffee breaks, and seasoned researchers discussing the latest data and research approaches. It can feel like a world reserved for insiders. Yet a recent study led by Dr Malgorzata Trela and Dr Sophie Rutschmann at Imperial College London argues that this lively professional gathering is precisely where tomorrow's scientists ought to cut their teeth. Their paper, “Immunology in Practice: a modular framework to support Master of Science students' conference attendance and engagement,” describes an educational project that turns a four-day professional congress into the beating heart of a master's-level module, and in doing so, reshapes how students learn, network and even see themselves.

Facial reconstruction is one of the most challenging fields in cosmetic and reconstructive surgery. When patients undergo skin transplants to address large facial defects, the surgeon's goal is to restore both the function and appearance of the face in a way that integrates seamlessly with their natural features. Dr Xusong Luo, Dr Lin Lu and their colleagues at Shanghai Ninth People's Hospital have developed an innovative approach that offers a promising new option for repairing large facial defects, particularly in children born with giant congenital melanocytic nevi.

Research from Professor Justin J. Joseph at the University of North Alabama examines the influences that impact the behaviour of underrepresented populations. In one study, he explores potential sex differences in the relationship between psychopathy traits, executive functioning, and youth gang membership. In a separate study, Joseph and colleagues investigated how information sources shape perceptions of campus carry policies among students at a Historically Black University.

Amino acids are a fundamental building block for fur, muscle, and every other living tissue on Earth. These molecules come in “left-handed” (L) and “right-handed” (D) forms, a bit like gloves that fit different hands or mirror images. Life largely runs on the left-handed set, so biologists once assumed the right-handed versions were irrelevant. Yet nature quietly manufactures these D-amino acids and they can play a role in certain biological processes. In research led by Japanese analytical chemist Ren Kimura of the R&D-Analytical Science Research department of the Kao Corporation, Japan, researchers reveal that these overlooked molecules may offer an early-warning beacon for one of the most common and deadly ailments in cats, chronic kidney disease (or CKD for short), and they may even have potential in diagnosing human conditions.

If you picture doctors making their daily rounds through hospital floors, you might imagine a single doctor standing by a bedside, examining a patient's chart, or perhaps a group of doctors discussing a case right outside a patient's room. However, the future of hospital care may well look more like a well-choreographed team effort, with doctors, nurses, pharmacists, students, and patients themselves, all in the same room, and all working as one team. This is exactly what Dr. Sarah Hallen and her colleagues at MaineHealth Maine Medical Center Portland envisioned when they created the iPACE model, short for Interprofessional Partnership to Advance Care and Education. Launched in 2017, this model is not just changing how doctors are trained; it's leveraging team synergies to reshape what it means to deliver healthcare.

As our world becomes increasingly complex, the need for genuine self-development and "inner work" grows more important. Dr Kerstin Liesenfeld and colleagues at the Liesenfeld Research Institute explore how people develop and maintain authenticity throughout their lives. Their research reveals that authentic development follows distinct patterns and stages, occurring at different rates across various aspects of our personalities. This understanding could help shape more effective approaches to personal development and coaching.

Scientific discovery often unfolds in unexpected ways. What begins as a search for solutions to real-world challenges can lead researchers into unexplored scientific territory, where unconventional ideas emerge and spark debate. This dynamic was at the heart of research by Dr. Arthur W. Snow and Dr. Ramagopal Ananth in the Chemistry Division of the US Naval Research Laboratory. Their study aimed to address a pressing need: replacing fluorocarbon surfactants in firefighting foams. What they discovered would take them beyond firefighting applications and into fundamental questions about the nature of water itself.

In early 2020, the world changed almost overnight. As COVID-19 swept across the world, homes were repurposed as schools, playgrounds and classrooms were abandoned, and family routines changed utterly or vanished. People were forced to adapt to remote working, many lost their jobs, and a significant proportion of us experienced anxiety about the virus that had turned the world upside down. However, amid this pandemonium, one group of people was especially vulnerable: children. We often think of childhood as a carefree time, protected from responsibilities, worries and burdens. However, the pandemic shattered this illusion. For many children, it caused confusion, isolation, and fear. Recognizing the need to understand this impact, Dr. Carlos Lastra and his team of researchers at Saint Peter's University Hospital in New Jersey, undertook an essential study: assessing how the pandemic affected anxiety levels in children and adolescents.

Are we primarily motivated by self-interest, or can activities that advance the progress of others provide similar or even greater levels of motivation? Logically, it would seem that people are most motivated to achieve specific goals when they are doing things that benefit themselves. Examples include studying for an exam, doing regular physical exercise, or working toward a career milestone; all activities that have tangible and readily apparent benefits for the individual pursuing them. Consequently, many of us would tend to believe that personal progress is our biggest driver. However, a recent study by Prof. Olya Bryksina from the University of Winnipeg reveals a surprising twist in how motivation works, especially when we're part of a group. In her innovative research, published in Motivation Science in 2025, Professor Bryksina explores a question many of us encounter daily but rarely think deeply about: What makes people put in effort when working toward a shared goal as part of a group? Her findings suggest something profound, that helping others in a group can be more motivating than helping ourselves.

In our increasingly interconnected world, sharing knowledge freely and fairly is crucial for ongoing development and progress. Increasing the overall size of our store of knowledge is important in dealing with the challenges we face in the modern world, but determining who can access and add to that knowledge is a key question. Prestigious academic journals and global conferences aim to help disseminate our most important discoveries and innovations, but researchers do not have equal access to such resources to promote their ideas and consequently not all voices are heard equally. Scholars from low- and middle-income countries continue to face invisible walls that limit their participation in the global exchange of ideas. This systemic imbalance is the focus of a deeply insightful study by Dr. Angel Ford of the University at Albany and Dr. Daniel Alemneh of the University of North Texas, who call for a more just and healthier scholarly communication system.

Thyroid cancer is one of the more common cancers globally, and for most patients, the prognosis is generally favorable with timely and effective treatment. The usual course involves surgery to remove the thyroid gland, followed by radioactive iodine therapy to eliminate any remaining cancerous cells. However, for a subset of patients, the story is far more complicated. When thyroid cancer no longer responds to radioiodine therapy, a condition known as radioiodine-refractory differentiated thyroid cancer, the outlook becomes significantly more daunting. These patients face limited treatment options and a much grimmer prognosis.

Research from Troy Norris at the WellBalance Institute for Positive Wellbeing reveals how a novel approach to measuring wellbeing can lead to more effective personalized interventions. The Wellbeing Balance and Lived Experiences (or WellBalance) Model and Assessment extends traditional wellbeing measures by evaluating both positive experiences and the feelings they generate, enabling tailored approaches to enhance individual flourishing based on specific life circumstances.

While checklists are often a vital tool for medical procedures, there has so far been little guidance on how they should be designed and applied in real medical scenarios. Now, a team including Dr. Alex Chaparro, a researcher at Embry-Riddle Aeronautical University, has developed an algorithm which can help medical experts to decide when a checklist is the best-suited tool for the task at hand; and if so, which type of checklist should be applied, based on the user's technical experience. The approach could ultimately help complex, potentially urgent medical procedures to become safer and more efficient.

Research from Professor Mamta Jain at UT Southwestern Medical Center and her colleagues reveals how electronic alerts, patient navigation, and mailed outreach can significantly increase hepatitis C screening and treatment in traditionally difficult-to-reach populations. Their work demonstrates that while electronic reminders are effective, combining multiple approaches with adequate clinical staffing and resources leads to the greatest improvements in patient care across all stages of the hepatitis C care continuum.

Research from Dr Aikaterini-Christina Koula at Manchester Metropolitan University reveals how legal systems are increasingly being weaponized to silence human rights defenders, particularly in Europe. Her work introduces a taxonomy of violations perpetrated through the legal system and demonstrates how these tactics deviate from human rights standards, offering valuable insights for academics, practitioners, and defenders alike.

Corn is a cornerstone of modern agricultural food production, particularly in North America. Humans have selectively bred such crops over generations to create better yields, improved appearance and flavor and enhanced disease resistance. However, what if we could skip these arduous rounds of selective breeding and improve a crop's stability and reliability regardless? Deep within the genetic blueprint of every maize kernel, scientists are aiming to achieve just this. In a recent groundbreaking study, Dr. Jon Reinders of Corteva Agriscience and his colleagues have unveiled a powerful new way to create genetically improved corn, not in a lab dish, but inside the plant itself. This new method is faster, cleaner, safer, and could transform how we grow our most essential crops.

Research from Professor Rumi Kato Price at the Washington University School of Medicine and her colleagues, Professors Sheldon Zhang and Annah Bender, reveals how research-driven, standardized indicator approaches can better identify human trafficking victims than traditional legal and prosecutorial frameworks. Their work in Cape Town, South Africa demonstrates that trafficking victimization exists on a spectrum rather than as a binary classification, with implications for improving identification and support for victims worldwide.

Research from Professor Germaine A. Hoston at the University of California, San Diego, reveals how traditional Chinese philosophical idealism influenced the development of Chinese Marxism. Her findings demonstrate that despite their rejection of China's feudal past, key Chinese Marxist theorists like Li Dazhao and Mao Zedong incorporated elements of Neo-Confucian idealism into their revolutionary philosophy. This "sinification" of Marxism drew particularly on concepts of consciousness, will, and the unity of knowledge and action from traditional Chinese thought, creating a uniquely Chinese revolutionary philosophy that challenged Soviet economic determinism.

Sitting directly over a complex network of fault lines, Haiti is one of the most earthquake-prone nations on Earth. In 2021, the Nippes earthquake became the latest to devastate the country, and today, researchers are still piecing together the timeline of seismic events which unfolded during the earthquake. Through their research, Professor Jeremy Maurer and colleagues at Missouri University of Science and Technology have described how the Nippes earthquake originated, shifted, and ruptured a major fault line, triggering numerous ‘afterslip' events in the following days.

Research from Professors Tristan Nighswander and Ariel Roddy at Northern Arizona University examines the effects of pre-employment training on employment outcomes for previously incarcerated individuals through the lens of two economic theories. Their findings reveal that while training significantly improves employment outcomes for the general population, it shows no meaningful benefit for those with incarceration histories. Even more surprisingly, high-ability individuals (defined through scores on an aptitude test called the Armed Forces Qualification Test, or the AFQT) with past incarceration may actually experience negative employment effects. This highlights the complex challenges of societal re-entry.

We can imagine our health as a jigsaw, with each individual piece representing a different aspect of our medical history. These pieces might include blood test results, X-ray images or the notes taken by a doctor as we describe our symptoms. These jigsaw pieces are ultimately recorded and stored in electronic health records (or EHRs). EHRs are a valuable resource, providing an overview of someone's health and they could have the potential to allow clinicians and researchers to unlock new medical insights. However, there's a fly in the ointment - not all the pieces in such records always fit together correctly, and they may not completely capture the required information. Some clinical event documentation may not be complete, others do not align with related pieces, and some events are even missing entirely. This data quality problem was tackled by Dr. Hanieh Razzaghi of the Children's Hospital of Philadelphia, and her colleagues, in their innovative work on the PRESERVE study, a research project exploring chronic kidney disease in children (the PRESERVE study itself was led by Drs. Michelle Denburg and Christopher Forrest). Using EHRs from 15 different hospitals across the United States, the team aimed to understand how various treatments could potentially slow down chronic kidney disease progression. However, initially, they had to make sure that the data they were relying on were accurate, reliable, and suitable for the required complex analyses.

Associate Professor Yassir Mahgoub and his team at Penn State University have uncovered an important link between melancholia – a severe form of depression that often doesn't respond to treatment – and catatonia – a condition characterized by abnormal movements and associated with schizophrenia. The researchers analyzed case studies involving six patients who had been hospitalized for severe depression. All six patients experienced significant relief from their depressive symptoms by taking lorazepam – a drug typically used to treat catatonia. This discovery reveals a potential new avenue for treating severe, treatment-resistant depression.

Our gut contains a sleepless army, creating a hostile environment for pathogens, and helping to fortify our body's immune defences. It may surprise you to learn that this army isn't even human in nature, but is bacterial. The trillions of bacteria that naturally live in our gut, known as the gut microbiota, form an important component of our overall immunity against infectious disease. While bacteria can also cause disease, beneficial bacteria naturally colonise available spaces in our body, such as the gut, and play a key role in our immunity and physiology. Research conducted by Prof. Nelson Gekara of Stockholm University in Sweden and colleagues has revealed that these microscopic organisms play a crucial role in protecting us from viral infections, even in organs that are unconnected to the gut. Their study, published in the journal Immunity, uncovers a fascinating link between the gut microbiota and our body's ability to fight viruses, offering new insights into immune function and the unintended consequences of antibiotic use.

A recent paper from Professor William Gardner at Texas Tech University and Professor Kelly Davis McCauley at West Texas A&M University challenges a critique that characterized authentic leadership theory as “wrong” and "perilous." Their analysis demonstrates how misrepresentations of the theory can undermine valuable leadership approaches, while highlighting the empirical support and practical benefits of leaders striving for authenticity in organizational settings.

Cancer is a daunting healthcare challenge, and is still affecting millions worldwide, despite the enormous research resources that have been directed at finding effective treatments over the past decades. Many anti-cancer treatments remain poorly specific for the tumours they are intended to treat, and often suffer from modest efficacy and serious off-target effects. Part of the problem is the inherent variability between many tumours and their resulting unpredictable responses to standard chemotherapy. However, the latest advancements in precision oncology may be the start of a new paradigm, potentially providing targeted therapeutic payloads that can successfully address the specific and unique issues underlying a given patient's cancer. Researchers such as Prof. Diana Jaalouk and her colleagues at the American University of Beirut in Lebanon are pioneering innovative tools that are changing the way we understand and treat this complex disease. Two remarkable recent technologies, CRISPR-Cas9 and PROteolysis TArgeting Chimeras (or PROTACs for short), are at the forefront of this precision revolution. While distinct in their approach, these tools share a common goal: targeting cancer with precision and minimizing harm to healthy cells. Together, they are set to reshape the therapeutic landscape.

When most of us think about poultry, our minds often turn to chickens, the staple of farms and dinner tables worldwide. However, Nigeria is home to several other fascinating types of poultry beyond the humble chicken that have played significant roles in the country's agriculture, culture, and economy. While these poultry species are firmly embedded in the Nigerian agricultural system, the history of how and when these animals came to be domesticated and where these populations originally derived from is often obscure. Recent research conducted by Dr. Adeniyi Charles Adeola of the Chinese Academy of Sciences, and colleagues, has shed new light on three often-overlooked poultry species, the Muscovy duck, the domestic pigeon, and the helmeted guinea fowl. These birds not only offer valuable genetic resources but also hold keys to food security, sustainable farming, and biodiversity conservation.