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Nels and Vincent take apart an amazing symbiosis consisting of two bacteria, one bacteriophage, and seven different genomes all within a single-celled alga. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode •Join the MicrobeTV Discord server •A single crowded cryptomonad cell (Curr Biol) •Letters read on TWiEVO 94 Science Picks Nels – What happened at NIH during the last government shutdown Vincent – Geneticist J. Craig Venter: ‘I consider retirement tantamount to death' Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv
Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Contribute to Parasites Without Borders Microsporidian impairs Plasmodium transmission (Nat Comm) Hero: Eugene T. Lyons (obituary) Image credit: Josh Letters read on TWiP 184 Become a patron of TWiP. Case Study for TWiP 184 69 yo female with several months of abdominal symptoms started in S. Africa, water shortage as described for her husband in the previous TWiP. Husband had C. cayetanensis. Her symptoms improved; her stool was positive for B. hominis and E. nana. Given many different treatments. Then comes to see Daniel. Some abdominal discomfort, mucosy stools. All past med/surg unremarkable, nothing in family, sent for repeat labs, stool O&P all normal including GI PCR Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect. Links for this episode: Human coronavirus 229E infectivity on common surfaces (mBio) Aerosol and surface stability of SARS-CoV-2 (medRxiv) Peptidoglycan synthesis by a insect-bacteria mosaic (Cell) Letters read on TWiM 213 Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv
The tetracoccal TWiM team visits Tardigrades on the Moon, and the twelve year quest to isolate an archaeon that provides insights into the emergence of the first eukaryotic cell. Links for this episode: Tardigrades on the moon (Mashable) Meet the Tardigrade (WaPo) Archaeon at prokaryote-eukaryote interface (bioRxiv) Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv
The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components. Become a patron of TWiM. Links for this episode: Take the TWiM listener survey Bacteria store energy for gutless worms (PNAS) Paracatenula on TWiM #21 E. coli extracts nutrients from host cells (Cell) Image credit Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv
The TWiP legends solve the case of Surfer Sans Septum, and discuss how two symbiotic bacteria in the tsetse fly allow colonization with Trypanosoma brucei. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: A Tale of Three Species (mBio) V.B. Wigglesworth (Wikipedia) VB Nimble, VB Quick Hero: James Paget Letters read on TWiP 164 Case Study for TWiP 164 Welcome to Uganda. Mother brings in 4 yo female child, end of rainy season, concerned that has one day of fever, headache, cough. On exam looks ill, unremarkable except rapid heart rate, localized crackles in right lower lung. Several children in family. Spends day swimming in local stream. Take care of animals. Help gather drinking water in morning. Live in dirt floor home, thatch roof, with animals around. Saw many others with same problem. What tests do you want to do? Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Oldest human plague from 4,900 years ago (PNAS) Engineering yeast endosymbionts (PNAS) Letters read on TWiM 191 TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to "mailto:twim@microbe.tv">twim@microbe.tv
The TWiP professors solve the case of the Woman With Intracellular Ring Forms, and explore the role of Coxiella and Rickettsia endosymbionts in acquisition of Babesia by ticks. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Endosymbionts and Babesia in ticks (Front Microbiol) Q fever with Robert Heintzen (TWiM Special) Hero: Percy Garnham Image credit Letters read on TWiP 157 Case Study for TWiP 157 Back to Thailand. Housewife, complaint has multiple red bumps on body, intense itching, worse at night. On head, legs, upper chest. Also does not feel well, feverish, muscle aches, difficulty breathing. Moved into abandoned residence, symptoms began a few days later. Many coconut husks around. Thatched roof. Husband and children developed similar symptoms. No med/surg history, no allergies. No meds. Unused mattresses, rat nests around. No toxic habits, no travel. No pets. On exam: not febrile, not toxic, increased heart, breathing comfortably. Has multiple red papules, central punctum. Labs unremarkable. Diff: unremarkable 6% eosinophils. Skin scraping from lesion on chest done. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!). Become a patron of TWiV! Links for this episode Predators allow virus infection of endosymbiont (PNAS) Image credit Letters read on TWiV 416 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:34:40 Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05 Register for the 2017 ASM Grant Writing Online course. Weekly Science Picks Alan - Cubes in Space Dickson - The Architecture of Eden by H. Pearlman and A. Whalley Rich - Studying the building blocks of life in stereo (original paper)Kathy - Ancient bottom wipes yield evidence of diseases (original paper) Vincent - Iguana vs snakes Send your virology questions and comments to twiv@microbe.tv
The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts. Links for this episode: Antimicrobial peptides to modulate microbial ecology (PNAS) Targeting specific bacteria in the oral microbiome (Trends Micro) How Wolbachiakills male hosts (PLoS Biol) Wolbachia phage on TWiV 332 Image: Transmission electron micrograph of Wolbachia within an insect cell. By: Scott O'Neill - Genome Sequence of the Intracellular Bacterium Wolbachia. PLoS Biol 2/3/2004: e76.
Host: Vincent Racaniello Guests: Seth Bordenstein, James Crowe, and Mark Denison Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses. Links for this episode SARS-CoV error correction (PLoS Path) 19:00 Marburg virus neutralization by a human antibody (Cell one and two) 56:35 Phage WO, Wolbachia and Drosophila (Peer J) 1:02:00 Seth's blog Symbionticism 1:31:30 Seth on Twitter Video of this episode: view at YouTube Timestamps by Jennifer. Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson. Vincent, Elio, Michael, and Michele consider whether our eating behavior is manipulated by gastrointestinal microbiota, and an aphid gene of bacterial origin whose gene product encodes a protein that is transported to an obligate endosymbiont. Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app. Links for this episode National Biosafety Stewardship month Aphid gene of bacterial origin (Curr Biol) Eroding symbiont/organelle distinction (Curr Biol) Is our eating manipulated by our microbiota? (Bioessays) Road to microbial endocrinology (STC) Microbial endocrinology (STC) Letters read on TWiM 86 Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson. Vincent, Michael, Elio and Michele discuss how an endosymbiont betrays its aphid host to alert plant defenses, and a new immunosuppressive cell that allows infection of neonates. Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app. Links for this episode Endosymbiont protein betrays aphid (PNAS) Plant immune system (Nature) Plant defenses against pathogens (Am Phyt Soc) New neonatal defense against infection (Nature) Marty Blaser and Bill Maher (YouTube) Two days from any village (YouTube) Letters read on TWiM 82 Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
The complete TWiV gang discusses the use of Wolbachia to control mosquito-borne infections.
In this NewsFlash, we hear how the proton appears to be smaller than we thought, prompting a reevaluation of some trusted laws of physics, how antidepressants in seawater can make shrimps swim towards danger and why some male fireflies flash together. Plus, a novel mechanism for natural selection - beneficial bacteria!
The role of lasers in biomedicine goes under the spotlight this week as we explore the workings of photodynamic cancer therapy, find out how laser tweezers can be used to force-feed bugs to white blood cells and hear how a new technique uses laser-powered DNA nanoswitches to spot specific genes. Also, why the proton just got smaller, prompting a reevaluation of some trusted laws of physics, how antidepressants in seawater can make shrimps swim towards danger and a novel mechanism for natural selection - beneficial bacteria! Plus, in Kitchen Science, what the patterns produced by laser light... Like this podcast? Please help us by supporting the Naked Scientists
The role of lasers in biomedicine goes under the spotlight this week as we explore the workings of photodynamic cancer therapy, find out how laser tweezers can be used to force-feed bugs to white blood cells and hear how a new technique uses laser-powered DNA nanoswitches to spot specific genes. Also, why the proton just got smaller, prompting a reevaluation of some trusted laws of physics, how antidepressants in seawater can make shrimps swim towards danger and a novel mechanism for natural selection - beneficial bacteria! Plus, in Kitchen Science, what the patterns produced by laser light... Like this podcast? Please help us by supporting the Naked Scientists