Podcast appearances and mentions of Ronald Jenkees

TWiM explains a study of the unique and extreme microbial and chemical environment on the International Space Station, and the connection between the gut microbiome and pain in fibromyalgia. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode ISS chemical and microbial environment (Cell) Gut microbiota and fibromyalgia pain (Neuron) Gut pain eases after doses of gut microbes (Nature) Skin innervation and fibromyalgia pain (Ann Neurol) Altered microbiome in fibromyalgia (Pain) Intestinal microbiome and fibromyalgia (Intl J Rheum Dis) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP describes how a gut commensal protozoan influences respiratory disease outcomes by shaping pulmonary immunity, and body shape variation in lice that parasitize diving hosts. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Gut commensal shapes pulmonary immunity (Cell) The deeper the rounder (Sci Rep) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiM describes isolation of a novel bacterial species isolated from the China Space Station, and how a chemical radar allows bacteria to detect and kill predators. Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin. Guest Mark O. Martin. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Niallia tiangongensis from the China Space Station (Int J Syst Evol Biol) Bacterial chemical radar (Cell) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP solves the case of the man in the Malaysian city of Kucheng who presents with left arm swelling, and presents a new case for you to decipher. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 257 New Case We are still in Kuching, Malaysia in the northern part of the Island of Borneo. This is the Sarawak portion of Malaysia. A man in his late 30s is admitted to the hospital in December with daily fevers that last for several hours and shaking chills. He had previously been healthy with no medical problems. He lives in the city and works in an office, however, in the few weeks prior to getting admitted he was visiting the jungle. Apparently not too far outside of Kuching, one can go up into the jungle and see Orangutans. He had gone into the jungle but this was 2 weeks prior to the onset of symptoms. Since then he reports no unusual exposures. He lives with his wife and children and they are all healthy. A few days prior to admission he noted fever, chills, and a headache. He is a little nauseated but no vomiting. On exam he has a fast heart rate and appears ill. His respiratory rate is increased and he is not febrile on admission but later does have fever.  No enlargement of the liver or spleen on exam. Otherwise unremarkable. His labs are notable for low white blood cells, anemia, and a platelet count of less than 50k per microL. His coagulation studies are abnormal, serum creatinine is elevated, and there is elevation of his serum aminotransferases. Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiM explains how to recode E. coli so it uses only one stop codon, and an exploration of the mechanisms of bacterial adhesion within dental plaque. Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Engineering E. coli with one stop codon (Nature) Bacterial adhesion in dental plaque (mBio) Microbial complexes in subgingival plaque (J Clin Periodontol) Bacterial clusters in periodontal and peri-implant diseases (Microorg) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Naegleria fowleri acquired at splash pad (MMWR) Determinants of P. falciparum drug resistance (Science) Paleoparasitological analysis of 5th–16th c. CE latrine (Parasitol) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Michelle Labrunda Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 255 New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves.  Hint: this is not Wuchereria Bancrofti. Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiM explains Pasteur's relentless hunt for microbes in the air, and how bacteria hunt for prey by ixotrophy - using grappling hooks! Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Pasteur's hunt for microbes in the air (NYTimes) Bacterial predation by ixotrophy (Science) Enter the pirates (STC) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiM describes Shigella infection is facilitated by interaction of human enteric α-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode National Black HIV/AIDS awareness day (CDC) Shigella infection and human enteric alpha-defensin 5 (Nature Microbio) RNA polymerase amino acid change and resistance to beta-lactams (Cell Rep) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 253 New Case 26-year-old female with no past medical history.  Patient is from Georgia in the US and is volunteering in Hérico, Guinea (town in the Lélouma Prefecture in the Labé Region of northern-central Guinea). She arrived in Guinea in December  2023.  She was taking doxycycline for malaria prophylaxis and says that she has not missed any doses On October  2024 she presented with fever and dry cough.  Lab work was done and follow up planned for the following day.  The patient slept poorly, was febrile to 104 and had ongoing cough.  The next day she went to the hospital and was evaluated in the ER for acute febrile illness of unclear etiology.   In the hospital, VS were 97.9F, BP 105/70, P 94 Oxy sat 98%, normal physical exam. She was started on Augmentin and Coartem. Pause here to think about the differential at this point and maybe some more history and what testing you might want WBC 14, Hb 13, HCT 40, PLT 285, Neut abs 8, Eos Abso0.80; BUN/creat  normal, AST normal; ALT 44, GGT 125 Stool parasite screen + for some sort of eggs, malaria smear negative, CXR with b/l infiltrates She was given a medication (vomited 30 min after dose received).  She then received a second dose of medication 5 hours after the first) and was discharged. The following day the patient returned to the ER, stating that she felt worse.  Her temperature had climbed to 104 overnight, and she developed watery diarrhea and nausea.  There were no additional episodes of vomiting.  She was given an additional dose of a medication, ibuprofen, and started on ceftriaxone 1 gm IV Q12 hrs.  During the day she continued to have low grade fevers and developed abdominal pain.  That night she was again febrile to 104 F.    She remained admitted for 5 days with ongoing symptoms of diarrhea, nighttime fevers and diffuse abdominal discomfort.  Three more malaria tests were negative (rapid test and slide review) Blood cultures collected – no growth She continued to have mild elevation of WBC and slight elevation of AST and ALT. The patient was transferred to a different hospital. They give her a different medication, and within 24 hours symptoms resolve.  What is the diagnosis and what happened here with management? Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Live attenuated malaria vaccine (NEJM) Plasmodium metabolism during hepatic development (Cell) Heroes – Jimmy and Rosallyn Carter, and the Carter Center The Carter Center Guinea Worm Eradication Programme Guinea Worm data visualisations (Our World in Data) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiM explains the remarkable abilities of bacterial ice nucleating proteins to promote freezing of water, and cryoprotective proteins produced by worm microbiomes that prevent freezing. Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Worm microbiomes produce crytoprotective proteins (Sci Adv) Biological antifreeze in Antarctic fishes (Sciece) Enhancement of bacterial ice nucleators (PNAS) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiM explores the discovery of microbial enzymes, PETases, that can degrade ubiquitous plastics, and how exogenous peptidoglycan is a danger signal to trigger biofilm formation. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson. Guest Mark O. Martin. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Discovery of PET depolymerases (Science) Exogenous peptidoglycan triggers biofilm formation (Nat Micro) What is a biofilm? (Vimeo) Peptidoglycan as a PAMP/MAMP (Immunol Rev) Light organ formation triggered by peptidoglycan (Science) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiM reveals that record high atmospheric methane growth has been driven by microbes, and the cecum as an adaptive niche for Salmonella typhi. Hosts: Michael Schmidt, Petra Levin and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Why a potent greenhouse gas is rising (WaPo) Microbial emissions drove record high atmospheric methane growth (PNAS) Salmonella biofilm formation in the cecum (mBio) Typhoid Mary (The Collector) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP reviews a study showing that the gut microbiota is essential for suppression of colitis by Trichinella spiralis. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Gut bacteria and Trichinella suppression of colitis (PLoS NTD) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

From ASMCUE 2024, the conference on undergraduate education, TWiM speaks with Becky, Melanie, and Katriana about their careers and how they use TWiM in undergraduate microbiology education. Hosts: Michael Schmidt and Mark O. Martin Guests: Becky Seipel-Thiemann, Melanie Melendrez-Vallard, and Katriana Popichak Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiM describes how to make concrete more ‘green' by using microbes, and bacterial bioluminescence as an important regulator of multitrophic interactions in the soil. Hosts: Vincent Racaniello, Michael Schmidt, and Mark O. Martin. Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Links for this episode Construction nanobiotechnology for concrete (Appl Env Micro) Self-healing concrete (Sci Tot Environ) Microbe-inspired self-healing concrete (Front Struct Civil Eng) Bacterial bioluminescence regulates multitrophic interactions in the soil (Cell Rep) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

TWiP taps into Dickson's knowledge of Trichinella to discuss an outbreak in humans who consumed rare bear meat, and the impact of globalization and climate change on the epidemiology of the species. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Outbreak of human trichinellosis (CCDR) Impact of climate change on Trichinella (Food Waterborne Parasit) Letters read on TWiP 246 Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Lilach Sheiner joins TWiP to talk about her career and her work on engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Hosts: Vincent Racaniello, Dickson Despommier, and Christina Naula Guest: Lilach Sheiner Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Engineering T. gondii for protein secretion (Nat Micro) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP solves the case of the Woman with White Worms, and submits a new case involving a 1 year old in northeastern Panama with a fatal leg infection. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Enterobius, the pinworm (TWiP 19) Hero: Mary Pritchard New Case This case comes from Panama mid summer 2024. A provider for Floating Doctors working in the coastal region in northeastern Panama. This case involves a one year old, so the history is a bit difficult, but there may have initially been a scratch or some sort of break in the skin. Otherwise healthy but over a period of time this area expands and becomes a deep necrotic wound on the leg. Several other nearby wounds develop and become deep and infected. By the time this one year old is seen by the provider much of the leg appears eaten away. This is just the tip of the iceberg as a number of others develop similar wounds in the area. No prior medical history. Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP reviews a study showing that intestinal helminth infection impairs vaccine-induced T cell responses through an IL-10 pathway, which compromised protection against antigenically drifted SARS-CoV-2 variants. Hosts: Vincent Racaniello, Daniel Griffin and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Worms impair COVID vaccines (Sci Trans Med) Heligmosomoides image (Wiki Commons) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiM explores evolution and host adaptation of Pseudomonas infections of plants, and the impact of COVID-19 on ESBL-producing E. coli on urinary tract and blood infections. Hosts: Vincent Racaniello and Michael Schmidt. Become a patron of TWiM. Links for this episode Evolution and host adaptation of Pseudomonas (Science) Type III secretion system, infection by injection (Nat Comm) Demographic inference with skyline plots (Peer J) Skyline plots (Taming the Beast) Panaroo, a bacterial genome analysis pipeline (Wellcome Sanger Inst) Impact of COVID-19 on ESBL-producing E. coli infections (Antimicro Resist Inf Control) Take the TWiM Listener survey! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

On episode #60 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/18/20 – 7/31/24. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Olympics Swimming in the Seine (NYTimes) Viral Twice-Yearlylenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women (NEJM) Consensus definitions of Cytomegalovirus Infection and Disease in Transplant Patients (CID) The recombinant shingles vaccine is associated with lower risk of dementia (Nature Medicine) Association of the incidence of postherpetic neuralgia with early treatment intervention of herpes zoster (International Journal of Infectious Diseases) Bacterial Updated guidelines for antimicrobial resistant gram-negative infections (IDSA) Put the Vanc Down, Flip it and Reverse it: Comparison of vancomycin and daptomycin (OFID) Durations of antibiotic treatment for acute otitis media and variability in prescribed durations (Journal of Pediatric Infectious Diseases Society) Fungal Adjunctive single-dose liposomal amphotericin to prevent cryptococcal meningitis in people with human immunodeficiency virus (HIV)–associated cryptococcal antigenemia and low plasma cryptococcal antigen (CrAg) titers(CID) Stagonospora cutaneous infection in a kidney transplant recipient: First human case (Transplant Infectious Disease) European Study of cerebral aspergillosis treated with Isavuconazole: an EFISG study (CID) Parasitic Rollout of world's second malaria vaccine begins in Ivory Coast (Healio) Executive summary: Evaluation and management of delusional infestation(CID) Parasitic contamination of soil in the Southern United States (ASTMH) Miscellaneous The potential benefits of delaying seasonal influenza vaccine selections for the northern hemisphere: A retrospective modeling study in the United States (JID) Music is by Ronald Jenkees

Sean Murphy joins TWiP to discuss his career and the work of his laboratory to assess the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda. Hosts: Vincent Racaniello, Dickson Despommier and Christina Naula Guest: Sean Murphy Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Daily natural history of Plasmodium infections (Lancet Microbe) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #59 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 7/3/20 – 7/17/24. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral The potential interrelationship of coronary artery disease -herpes zoster (OFID) Bacterial Pharmacokinetics of intravenous antibiotics into the infected pleural space (Thorax) Are gas emissions from microbiology cultures significant contributes to global warming?(OFID) Is combination treatment of ampicillin and gentamicin right for Listeria monocytogenes infection (Infection) Screening organ donors and monitoring recipients for Bartonella quintana (OFID) Neglected Tropical Disease: Rocky Mountain spotted fever (PLoS Pathogen) Updated guidelines for antimicrobial resistant gram-negative infections (IDSA) Fungal Are fungal pathogenssmarter than we are? (microbeTV) What influences the waning of antibodies during cryptococcal meningitis? (JID) Parasitic Artificial Intelligence for filariasis diagnosis and monitoring (PLoS Neglected Tropical Diseases) Is artificial intelligence the end of filariasis? (PLoS Neglected Tropical Diseases Miscellaneous APACHE II severity of disease classification system (GlobalRxPh) Clinical practice guideline for complicated intra-abdominal infections (CID) Procalcitonin or C-reactive protein guided antimicrobial discontinuation to treat sepsis (Critical Care Medicine) The “plague” of plague for the Neolithic population (Nature) Music is by Ronald Jenkees

On episode #58 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/20 – 7/3/24. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience) Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN) EBV and KSHV caused HIV associated cancers and lymphoproliferative disorders (Clinical Microbiology Reviews) Where in the CNS can dolutegravir, tenofovir, lamivudine and efavirenz be found? (JID) Therapeutic management of Varicella-Zoster virus meningitis (OFID) Bacterial Carbapenem use in extended-spectrum cephalosporin-resistant Enterobacterales infections (LANCET Infectious Diseases) IDSA guidelines (Columbia University) Guideline-Concordant Therapy for community-acquired pneumonia in the Hospitalized Population (OFID) Interpretive Criteria piperacillin/tazobactam susceptibility test for Enterobacterales (CID) FDA approval forCAPVAXIVE (FDA) 21 valent pneumococcal vaccine approved (Nature Reviews drug discovery) Antimicrobial resistant Staphylococcus aureus isolates (JAMA Network Open) Broad-spectrum antibiotic use for suspected community-onset sepsis (JAMA Network Open) Fungal The Last of Us ( Wikipedia) Challenges to vaccinating against coccidioidomycosis (OFID) Cryptococcosis: the story (OFID) Pneumocystis pneumonia: clinical spectrum, prophylaxis and delayed treatment (Intensive Care Medicine) Improve utilization of 1,3 β-D-glucan Testing(OFID) Music is by Ronald Jenkees

Michael Barrett joins TWiP to discuss progress in the elimination of human African trypanosomiasis caused by Trypanosoma brucei gambiense. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Michael Barrett Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Elimination of human African trypanosomiasis (PLoS NTD) Hero: David Livingstone Become a patron of TWiP  Send your guesses to twip@microbe.tv with TWiP 237 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #57 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 6/6 – 6/19/24. Host: Daniel Griffin Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Is letermovir or valganciclovir better to prevent CMV in kidney transplant recipients (JID) CMV antiviral therapy (GoodRx) Prevalence of and risk for CMV reactivation during COVID-19 pneumonia (PLoS One) Sofosbuvir off-label yellow fever treatment (OFID) Bacterial Preventing resistant gram negative bacteria through beta-lactam de-escalation in sepsis patients (CID) Competing risk analysis, survival analysis that aims to correctly estimate marginal probability of an event (Columbia University) Continuous or intermittent b-lactam infusion for critical sepsis (JAMA Network) Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock (JAMA Network) Phoenix sepsis score and risk in children with cancer (JAMA Network) New recognized spotted fever group Rickettsia in Northern California (Emerging Infectious Diseases) Screening for mycobacterium tuberculosis (Transplant Infectious Disease) Fungal Potential sexual transmission of Tinea pubogenitalis from TMWII (JAMA Dermatology) Household transmission of tinea infection (OFID) Drug-resistant oral candidiasis in HIV infected patients (BMC Infectious Disease) Parasitic Handheld digital microscope for rapid and comprehensive screening for urogenital and gastrointestinal schistosomiasis (American Journal of Tropical Medicine and Hygiene) Scorecard approach to eliminate onchocerciasis (Am J Trop Med Hyg) Miscellaneous Association between antibiotic receipt and provider rating (OFID) Infectious diseases and infection control prevention strategies when on ECMO (Perfusion) Music is by Ronald Jenkees

Marilyn Fabbri joins TWiP to reveal the case of a patient who became very ill after he and a number of friends attended a large dinner where venison and boar were served. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Marilyn Fabbri Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Toxoplasma gondii (TWiP 12) Parasitic Diseases Lectures #15: Toxoplasmosis Letters read on TWiP 237 Become a patron of TWiP  New Case Man in his 60s with HIV/AIDS CD4 count less than 50, CD4% less than 5% and elevated viral load (VL) with report of prior CNS toxoplasmosis requiring a craniotomy, disseminated Mycobacterium avium complex (MAC), comes in with fever and very watery diarrhea x 4 days. He reports that he lives in Georgia but comes up to NY for his HIV care and stays in NYC. Send your guesses to twip@microbe.tv with TWiP 237 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #56 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/28 – 6/5/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Highly pathogenic H5N1 in US dairy cattle and 2 human cases (MMWR) Developing novel treatments for acute COVID-19 should address long COVID (JID) Reactivation of inherited HHV 6B in transplant recipient (JID) Bacterial Suppressive antibiotic therapy after DAIR for acute periprosthetic joint infections (OFID) Piperacillin-tazobactam vs cefepime for sepsis treatment (JAMA Internal Medicine) Are the new diagnostic algorithms for pulmonary tuberculosis more sensitive? (OFID) Social factors associated with congenital syphilis (CID) Oral vancomyin treatment influences Clostridioides difficile recurrence in patients on concurrent systemic antibiotics Association between infectious diseases consultation and morality in Gram negative infected patients (CID) Fungal Not washing your hands: fluconazole-resistant Candida parapsilosis epidemiology (OFID) Retrospective case series: how Candida auris blood infections effect left ventricular assist devices (OFID) Trichophyton indotineae: clinical course, suspectibility and genome sequence (JAMA Dermatology) Screening serum for cryptococcal antigen in liver transplant recipients (OFID) Parasitic US outbreak of human trichinellosis (MMWR) Plague-ing the Pawlowsky glands of human body lice and transmission by bite(PLoS Biology) Miscellaneous Global change drivers and risk of infectious disease (Nature) ID specialists should care about ventilation (CMI) Music is by Ronald Jenkees

Marion Avril of MalarVx, Inc. joins TWiP to discuss an accelerated prime-and-trap regimen using repRNA-based circumsporozoite vaccine. Hosts: Dickson Despommier and Christina Naula Guest: Marion Avril Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute repRNA-based CSP malaria vaccine (NPJ vaccines) Hero: Mwelecele Ntuli Malecela Become a patron of TWiP  Send your guesses to twip@microbe.tv with TWiP 235 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #55 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 5/9 – 5/27/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Highly pathogenic H5N1 in US dairy cattle and 2 human cases (MMWR) Developing novel treatments for acute COVID-19 should address long COVID (JID) Reactivation of inherited HHV 6B in transplant recipient (JID) Bacterial Suppressive antibiotic therapy after DAIRfor acute periprosthetic joint infections (OFID) Piperacillin-tazobactam vs cefepime for sepsis treatment (JAMA Internal Medicine) Are the new diagnostic algorithms for pulmonary tuberculosis more sensitive? (OFID) Social factors associated with congenital syphilis (CID) Oral vancomyin treatment influences Clostridioides difficile recurrence in patients on concurrent systemic antibiotics Association between infectious diseases consultation and morality in Gram negative infected patients (CID) Fungal Not washing your hands: fluconazole-resistant Candida parapsilosis epidemiology (OFID) Retrospective case series: how Candida auris blood infections effect left ventricular assist devices (OFID) Trichophyton indotineae: clinical course, suspectibility and genome sequence (JAMA Dermatology) Screening serum for cryptococcal antigen in liver transplant recipients (OFID) Parasitic US outbreak of human trichinellosis (MMWR) Plague-ing the Pawlowsky glands of human body lice and transmission by bite(PLoS Biology) Miscellaneous Global change drivers and risk of infectious disease (Nature) ID specialists should care about ventilation (CMI) Music is by Ronald Jenkees

On episode #54 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/25 – 5/8/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Dengue: mother and child (American Economic Journal) Dairy farm worker and high path avian influenza A (H5N1) (NEJM) Respiratory virus pre and post transplant outcomes in children (CID) Bictegravir for HIV suppression during pregnancy (CID) Bacterial Group A Streptococcus pharyngitis: rapid diagnostic & antimicrobial stewardship (Pediatric ID Consult) Scrub typhus : Masquerade of disaster (OFID) One size fits all for UTI predictions? (CID) Infections of durable and acute mechanical circulatory support devices (Journal of Heart and Lung Transplantation) Fungal Crypto hosts for cryptococcal disease (NEJM) Parasitic Sampling for cutaneous Leishmaniasis (OFID) Skin monoclonal anti-Malaria antibody therapy (NEJM) Miscellaneous Origin of antimicrobial therapy (CID) Microneedle patches for MR (measles and rubella) vaccination (LANCET) Music is by Ronald Jenkees

TWiP discusses hookworm infection and the phase 1 clinical trial for a hookworm vaccine that could one day protect children from the hookworm anaemia, and reduce transmission of this infection. Hosts: Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hookworm vaccines in school-aged children in Gabon (Lancet Inf Dis) Step forward towards hookworm vaccines (Lancet Inf Dis) Hookworm vaccine protects dogs (FASEB J) Hero: Muriel Robertson Letters read on TWiP 233 Become a patron of TWiP   Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #53 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/11 – 4/24/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Reasons for what we do for routine respiratory pathogens (Journal of Hospital Medicine) Acute cardiac events due to RSV infection (JAMA Internal Medicine) Antiretroviral drugs and weight change (CID) What do antibiotics do for acute lower respiratory tract infection (Journal of General Internal Medicine) Guidelines for managing BK polyomavirus in kidney transplantation (Transplant) Bacterial Understanding Yersinia enterocolitica epidemiology(OFID) Medtronic duet external ventricular drain infections(MMWR) Who is more expensive daptomycin or vancomycin (OFID) Fungal Coccidioidomycosis related hospital visits (Emerging Infectious Diseases) Parasitic Leech in oropharynx of a 2-year old leads to anemia (AJTMH) The real use of ivermectin: treatment of strongyloidiasis (AJTHM) Miscellaneous Sporadic CJD in hunters? (Neurology) Where are all the infectious disease doctors? (OFID) Not interested in infectious diseases? Seriously! (CID) Music is by Ronald Jenkees

TWiP solves the case of the physician with no significant previous medical history who is currently doing their fellowship training develops diarrhea, and presents a new clinical case for our astute listeners to solve. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Keith Vickerman Letters read on TWiP 233 Become a patron of TWiP New Case study: I was recently asked about this case while I was off visiting Denmark. A man in his 50s has been reporting months of abdominal discomfort and decides to go discuss this situation with a local pharmacist. He describes this discomfort, some nausea, and some bloating of the abdomen. The pharmacist recommends that he take mebendazole. He takes the mebendazole and some time afterwards he vomits a worm into the sink. The worm does not have any obvious segmentation and appears completely nonsegmented and is moving around. One end is very pointy and the other little less so.   Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #51 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/28 – 4/10/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Winter vomiting disease (Open Forum Inf Dis) Ceftriaxone-Resistant Gonorrhea — China, 2022 (MMWR) Give me five days of antibiotics (JPIDS) Where did this come from (JPIDS) Differentiating cellulitis from pseudocellulitis (JAMA Derm) FLIR One Pro Neonatal Elizabethkingia anophelis meningitis from the water reservoir of automated infant milk dispenser (Eurosurveill) d-Mannose for Prevention of Recurrent UTI Among Women (JAMA Int Med) Oral vaccine for UTI potential alternative to antibiotics (Eurek!Alert) Oral vaccine for UTI trials BJUI one and BJUI two and NEJM NLRP3 inflammasome activation and type I interferon signaling predispose to necrotizing fasciitis (Cell Rep Med) Candida deep sternal wound infections: a consequence of antibiotic use? (OFID) Candida auris in US Correctional Facilities (Emerg Inf Dis) Scedosporiosis and lomentosporiosis: difficult-to-treat rare mold infections (Clin Micr Rev) Meeting the consultation surge (OFID) Music is by Ronald Jenkees

TWiP solves the case of the Woman With White Worms, and presents a new clinical case to decipher. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Ann Bishop Become a patron of TWiP New Case study: A physician with no significant PMH who is currently doing their fellowship training develops diarrhea. The diarrhea is significant enough that they are beginning to feel weak, lightheaded, and end up going to the local ER. The physician lives in NYC, works most of the time but did just get back from a week-long vacation in Florida with their long-term partner where they got a chance to swim in the pool and get some sun. They returned feeling well and then noted the onset of the diarrhea. The diarrhea was watery, with some abdominal cramping but no noted blood or actual fever. The stool did not have a strong smell and no floating stools were reported. The physician was given IVF and returned home feeling better but now gets a call that there is a parasite on the stool testing and is recommended to take a medicine they have never heard of 3x per day for 3 days.  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #49 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 2/14 – 2/27/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral HIV Cure?  (NEJM) The effects of HIV-1 antigen-expanded specific T-Cell therapy and vorinostat on persistent infection (JID) The burden of HMPV and influenza associated hospitalizations in adults (JID) Bacterial Length of antibiotic therapy among the hospitalized with uncomplicated pneumonia (Infection Control & Hospital Epidemiology) Guideline on fecal microbiota–vased therapies for some gastrointestinal diseases (Gastroenterology) Guideline on fecal microbiota–based therapies for recurrent C diff (CIDRAP) Reduced vancomycin susceptibility in Clostridioides difficile (CID) Fungal Histoplasmosisin non-HIV population (OFID) Parasitic Plasmodium falciparum under the host's Immune radar(JID) Did you hear Artemether-lumefantrine is recommended for uncomplicate malaria CID) Miscellaneous Uncompensated work in academic infectious diseases, seriously? (CID) Invasive mosquito Anopheles stephensi, Ghana (Emerging Infectious Diseases) Music is by Ronald Jenkees

Maria Adelaida Gomez joins TWiP to discuss her career and the work of her laboratory on understanding the healing process during cutaneous leishmaniasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Maria Adelaida Gomez Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CIDEIM Healing in cutaneous leishmaniasis (J Immunol) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #48 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/31 – 2/13/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Infectious attenuated tetravalent Butanatan-Dengue vaccine (NEJM) Kids with severe disease following first and second dengue virus infection (Nature) Oropouche fever outbreak in Latin America (Lancet Infectious Diseases) CMV mRNA vaccine knocks out gB/MF59 vaccine (JID) Acyuclovir-resistant mucocutaneous HSV in immunocompromised patients (OFID) Bacterial Dalbavancin for vertebral osteomyelitis (OFID) Severe vibrio vulnificus infections (MMWR) Demystifying UTIs in the era of antibiotic resistance (PLoS Pathogens) Syphilis testing recommendations (MMWR) Doxycycline vs azithromycin for scrub typhus (BMC Infectious Diseases) REALLY drug resistant Pseudomonas aeruginosa outbreak(CID) Fungal SUBA or conventional itraconazole for treatment of endemic mycoses (OFID) Fluconazole resistant Candida (CDC) Are you in the hospital too long after being treated with echinocandin for your Candidemia or invasive Candidiasis (OFID) Nasopharyngeal swab or lower respiratory tract specimen for Pneumocystis jirovecii diagnosis (OFID) Global guideline for cryptococcosis diagnosis and management (Lancet Infectious Disease) Parasitic Toxoplasma IgG positivity associates with increase mortality (AJTMH) Miscellaneous How well did infectious diseases fellows match (JID) Back to the future of the physician-scientist in infectious diseases (JID) Full or not infectious disease training (JID) Music is by Ronald Jenkees

TWiP discusses a tapeworm that causes extreme lifespan extension in infected ant workers, and a candidate antibody drug for prevention of malaria. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Extreme lifespan extension in tapeworm-infected ant workers (Roy Soc Open Sci) Candidate antibody drug for prevention of malaria Ceilidh goes viral (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

On episode #46 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/18 – 1/31/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Reinfection by Zika via genome diversity and antibody response (EID-Emerging Infectious Disease) People with HIV should breast/chest feed (CID) Norovirus GII in the water (PLoS Water) Herpes zoster and duloxetine premedication for neuralgia (CID) Bacterial SABATO: early oral switch trial (Lancet) Guideline for concordant antibiotic therapy to treat community-acquired pneumonia (Chest) Ceftriaxon with or without Nafcillin/Oxacillin for MSSA treatment (OFID) Ceftriaxone to prevent ventilator-associated pneumonia trial (Lancet) Azithromycin part of routine well-infant visits (NEJM) Burkholderia pseudomallei in Mississippi(NEJM) Cefiderocol red wine urine syndrome in children (Pediatric Infectious Disease Journal) Fungal InsuranceClaims equals blastomycosis Incidence (EID) Antimicrobial stewardship for coccidioidomycosis in endemic region (OFID) Endemic mycosesafter solid organ transplantation (OFID) Parasitic Headbobbing trematoda (CMI) Miscellaneous Suspected hemophagocytic lymphohistiocytosis (JPIDS) BioFire FilmArray for real-life assessment of hospitalized respiratory illness (JID) Clinical microbiology conferences gender and geography (Lancet) Is the toilet really the greatest sanitation invention? (AJICJ) Music is by Ronald Jenkees

On episode #46 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/4 – 1/17/24. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Comparing the performance of three models incorporating weather data to forecast dengue epidemics (JID) Elucidating the impacts of climate on dengue transmission through mathematical models (JID) Infants receiving a single dose of nirsevimab to prevent RSV do not have evidence of enhanced disease in their second RSV season (JPIDS) Patient perspectives on solid organ transplantation from donors with hepatitis C viremia to recipients without hepatitis C viremia (OFID) Oral Beta-Lactams, Fluoroquinolones, or Trimethoprim-Sulfamethoxazole for definitive treatment of uncomplicated Escherichia coli or Klebsiella species bacteremia from a urinary source (OFID) Discontinuation of contact precautions for methicillin-resistant Staphylococcus aureus in a pediatric healthcare system (JPIDS) Oral linezolid compared with benzathine PCN G for treatment of early syphilis in adults (The Lancet) Model-informed precision dosing improves outcomes in patients receiving vancomycin for gram-positive infections (OFID) The Xpert MTB/RIF cycle threshold value predicts M.tuberculosis transmission to close contacts (CID) Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (The Lancet) Oral antibiotics for treatment of Gram negative bacteremia in solid organ transplant recipients (CID) Dematiaceous fungal keratitis with tentacles mimicking Pythium Keratitis (Jama) Verification, analytical sensitivity, cost-effectiveness, and comparison of four Candida auris screening methods (OFID) Tafenoquine-Atovaquone combination achieves radical cure and confers sterile immunity in experimental models of human babesiosis (JID) Relapsing babesiosis with molecular evidence of resistance to certain antimicrobials commonly used to treat Babesia microti infections (OFID) Understanding parental leave policies in ID fellowship (OFID) What's hot this year in ID clinical science (CID) Music is by Ronald Jenkees

TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.   Become a patron of TWiM.   Links: S. aureus drives itch and scratch behavior (Cell) Staph scratches its itch (Cell) A new class of antibiotics (Nature) A new type of antibiotic (Nature) Novel antibiotic targets LPS transporter (Nature) New antibiotic traps LPS (Nature) Macrocyclic peptide drugs (Science) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv  

Jim Small joins TWiP to solve the case of the 41 year old Man with sudden GI distress and itchy hives, followed by a discussion of parasites and childhood stunting. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Jim Small Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Parasites and childhood stunting (Trends Parasitol) Letters read on TWiP 227 Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP reviews some parasite stories of 2023, including progress in the control of malaria and polio, and review a connection between parasites and childhood stunting. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Second malaria vaccine (Nature) Malaria report 2023 (WHO) Malaria and climate change (WHO) Parasites and childhood stunting (Trends Parasitol) Sea creature spotted off Japan identified (Science) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

TWiP solves the case of the Haitian female with AIDS and voluminous diarrhea, and review the pathogenesis, epidemiology, prevention and treatment of malaria and Chagas disease. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #223 (63 MB .mp3, 88 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Malaria (Lancet) Chagas disease (AJTMH) Hero: Joe Cook Letters read on TWiP 223 Become a patron of TWiP Case Study for TWiP 223 46 yo man with minimal pmh, elevated cholesterol, ongoing right upper extremity swelling, 5-10 years intermittently. Goose egg swelling on hand, foot. Lasts for hours, every few months. Go to ER, right upper extremity. Lives in NYS suburbs, Is vet and epidemiologist. Has done extensive travel, Liberia, Ghana, DRC, Uganda, Rwanda, 2 week duration. Doing work, fair amount of animal contact with bats, rodents, birds. PE unremarkable except for swelling of right arm. Blood work unremarkable. 2.5 yr later notice prickling irritation under right eyelid, think they see undulation under skin.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

At the meeting of the American Society for Tropical Medicine and Hygeine in Chicago, Natasha joins TWiP to solve the case of the Man with a Generalized Seizure and Infectious Forms in the Brain. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Natasha Spottiswoode Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Treatment of Balamuthia encephalitis with nitroxoline (Emerg Inf Dis) Letters read on TWiP 222 Become a patron of TWiP Case Study for TWiP 222 Haitian creole speaking, cachetic female in her 50s w/ hx HIV (noncompliant on medication), migrating from Haiti brought in by her daughter for dysphagia, cough x days, associated with NBNB vomiting, oral thrush extending to soft palate, concerning for oropharyngeal candidiasis. Weeks of nonresolving diarrhea. Admitted for failure to thrive and deconditioning, found to be Parainfluenza 3 positive), undergoing TB rule out. Diarrhea is voluminous, pt is dehydrated, there has been significant weight loss and lethargy over the last few weeks. MHx: HIV  Shx: Lives in haiti Remarried, Last sexual encounter 2 years ago. Denies illicit drug use. Drinks alcohol  Allergies: No Active Allergies Labs return with CD4 count in the 50s, elevated viral load. CD4 55/3% Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees