Podcasts about neurons

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Can the aging brain still make new neurons?   A landmark 2026 Nature study analyzed 355,997 human hippocampal nuclei using single-nucleus RNA sequencing and ATAC sequencing. Neurogenesis persists into adulthood—but chromatin accessibility collapses early in Alzheimer's disease.   SuperAgers showed a 2.5-fold increase in immature neurons and a preserved resilience signature.   Epigenetics may be the earliest battlefield in cognitive decline.

For decades, neuroscience treated the brain like a digital machine — storing information in synaptic connections and sustaining activity like a switch flipped on. But what if that model is incomplete?In this conversation, I sit down with Earl Miller, MIT professor and head of the Miller Lab, to explore a growing shift in cognitive neuroscience: the brain may compute using dynamic electrical waves.We discuss how oscillations coordinate millions of neurons, how waves interact with spikes in a two-way system, why large-scale brain organization may depend on rhythmic patterns, and what this means for artificial intelligence.If cognition isn't just stored in connections — but emerges from real-time analog wave computation — how should we rethink intelligence? TIMESTAMPS:(0:00) - Introduction: Mind-Brain Relationship Explained(0:27) - Brain as an Analog System: Dynamic Wave Computation(0:59) - 20th Century Brain Models: Connectionist Cognition(2:04) - AI Limitations from Old Brain Models(2:35) - Storing Information in Synaptic Connections(3:29) - Self-Organizing Brain & Internal Control Systems(4:29) - Brain Waves for Large-Scale Organization(5:17) - Spikes and Waves: Two-Way Brain Interaction(6:30) - Electrical Oscillations: Excitation & Inhibition Patterns(9:30) - Advantages of Wave-Based Processing over Logic Gates(11:00) - Coordinating Millions of Neurons for Attention(12:30) - Goals, Plans & Intentions Driving Brain Activity(15:30) - Real-Time Control: Synapses vs Waves Debate(18:30) - Generating New Brain Wave Patterns in Real Time(23:00) - Implications for AI & Cognitive Science(27:30) - Evolving Views on Cortical Computation & Oscillations(32:00) - High & Low Energy Phases in Brain Waves Explained(38:00) - Waves as a Mechanism for Self-Organization(44:00) - Real Analog Computation Through Wave Interactions(1:15:26) - Closing ThoughtsEPISODE LINKS:- Earl's Website: https://ekmillerlab.mit.edu/earl-miller/- Earl's Publications: https://scholar.google.com/citations?user=hv8jgk8AAAAJ&hl=en- Earl's X: https://x.com/MillerLabMIT- Earl's LinkedIn: https://www.linkedin.com/in/earlkmiller/- Cognition is an emergent property: https://doi.org/10.1016/j.cobeha.2024.101388- Analog Theory:https://loc.closertotruth.com/theory/millers-brain-waves-analog-organization-of-cortex- Cognition Emerges From Neural Dynamics Lecture: https://youtu.be/ie58Ujqy0vACONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That's why clinicians and researchers are excited about using oxytocin as a potential therapeutic. Brian Trainor is a professor at UC Davis, and his lab has been studying this complexity for the past decade. For an animal model, they work with a territorial, aggressive, monogamous rodent species called California mice. If the male is removed and the female is forced to defend their nest, she will experience what's known as social defeat, and she will exhibit what's called inhibited affiliative behavior, the type that can be affected by oxytocin — and this effect can be studied in a mouse's brain.Read the full study here: https://www.nature.com/articles/s41386-026-02352-y Hosted on Acast. See acast.com/privacy for more information.

You just have to be a good parent 30-40% of the time. According to the research, and parenting expert Maggie Dent.

If we’re all in the people business, then every leader needs to ask one question: What tools are in your toolbox? On this episode of Like It Matters Radio, Mr. Black unpacks the science and structure behind human behavior, motivation, and transformation. After nearly 34 years in the human potential field, he makes it clear: Nobody is broken. We are programmed. People run patterns—of thought, emotion, belief, and identity. And leaders who understand those patterns don’t just manage behavior… they transform it. This episode weaves together powerful frameworks including: Hebb’s Law – Neurons that fire together wire together Social Learning Theory – People model what they see Mimetic Theory – We imitate what we desire Attachment Theory – Secure relationships shape performance NLP patterning – Change the “how,” and the outcome changes You’ll also explore the deeper layers of transformation—Environment, Behavior, Capabilities, Beliefs, Identity, and Purpose—and why identity is the ultimate leadership superpower. If a pattern can be seen, it can be changed. If it can be changed, it can be repeated. If it can be repeated, it becomes a new reality. This episode equips leaders with practical insight to move, influence, and grow people from the inside out. Inspiration. Education. Application. When you live your life like it matters… it does. Be sure to Like and Follow us on our facebook page! www.facebook.com/limradio Instagram @likeitmattersradio Twitter @likeitmatters Get daily inspiration from our blog www.wayofwarrior.blog Learn about our non profit work at www.givelikeitmatters.com Check out our training website www.LikeItMatters.Net Always available online at www.likeitmattersradio.comSee omnystudio.com/listener for privacy information.

It was an honour to engage in a wonderful conversation with Lori about her Chapter, Calling All Neurons: A Literacy Journey. Lori generously unpacks several points about her journey in education and her book Calling All Neurons. An enormous thanks to Lori for spending the time, energy, and effort in sharing her Chapter and to everyone else that will engage with it. Lori can be found on:Amazon link: Calling All Neurons!: How Reading and Spelling HappenMy website: https://lorijosephson.com/Website links to my book: https://lorijosephson.com/calling-all-neurons-how-reading-and-spelling-happen/This conversation will be available on  ⁨@humanchapters⁩  YouTube, Podcast, and Facebook page.

What actually happens when AI stops being a cloud-only experiment and starts running on desks, in labs, and inside real teams trying to ship real work? In this episode, I sit down with Logan Lawler, Senior Director at Dell Technologies, to unpack how AI workloads are really being built and supported on the ground today. Logan leads Dell's Precision and Pro Max AI Solutions business and hosts Dell's own Reshaping Workflows podcast, giving him a rare vantage point into how engineers, developers, creatives, and data teams are actually working, not how marketing slides suggest they should be. We start by cutting through the noise around AI PCs. At every conference stage, Logan breaks down what genuinely matters when choosing hardware for AI work. CPUs, GPUs, NPUs, memory, and software stacks all play different roles, and misunderstanding those roles often leads teams to overspend or underspec. Logan explains why all AI workstations qualify as AI PCs, but not all AI PCs are suitable for serious AI work, and why GPUs remain central for anyone doing real model development, fine-tuning, or inference at scale. From there, the conversation shifts to a broader architectural rethink. As AI workloads grow heavier and data sensitivity increases, many organizations are reconsidering where compute should live. Logan shares how GPU-powered Dell workstations, storage-rich environments, and hybrid cloud setups are giving teams more control over performance, cost, and data. We explore why local compute is becoming attractive again, how modern GPUs now rival small server setups, and why hybrid workflows, local for development and cloud for deployment, are becoming the default rather than the exception. One of the most compelling parts of the discussion comes when Logan connects hardware choices back to business reality. Drawing on real-world examples, he explains how teams use local AI environments to move faster, reduce cloud costs, and avoid getting locked into architectures that are hard to unwind later. This is not about abandoning the cloud, but about being intentional from the start, mainly as AI usage spreads beyond developers into marketing, operations, and everyday business roles. We also step back to reflect on a deeper challenge. As AI becomes easier to use, what happens to critical thinking, curiosity, and learning? Logan shares a candid perspective, shaped by his experiences as a parent, technologist, and podcast host, raising questions about how tools should support rather than replace thinking. If you are trying to make sense of AI PCs, local versus cloud compute, or how teams are really reshaping workflows with AI hardware today, this conversation offers grounded insight from someone living at the center of it. Are we designing systems that genuinely empower people to think better and build faster, or are we sleepwalking into decisions we will regret later? How do you want your own AI workflow to evolve? Useful Links TLDR AI newsletter and the Neurons. The Reshaping Workflows podcast Connect with Logan Lawler Follow Dell Technologies on LinkedIn

Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that were once difficult to obtain. Our guests today focus on improving the derivation and study of sensory neurons, which are sparse and diverse nerve cells near the spine that carry information like pain, touch, or position of the body to the brain. Damage to these neurons or sensory neuropathies, as can happen in diabetes or infections, is estimated to affect millions of people worldwide, yet treatments are limited. To improve the generation of human sensory neurons, the authors developed a genetic toolkit to fluorescently label these individual cells and their subtypes. This approach enables more precise study of these subtypes, their roles in disease, and potentially the development of treatments for sensory neuropathies. GuestsJoriene C. de Nooij, PhD, Department of Neurology, Columbia University, USA Eti Malka-Gibor, PhD, Department of Neurology, Columbia University, USA HostJanet Rossant, Editor-in-Chief, Stem Cell Reports and The Gairdner FoundationSupporting ContentPaper link: Derivation and analysis of human somatic sensory neuron subtypes facilitated through fluorescent hPSC reporters," Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReportsAbout ISSCRAcross more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to advancing stem cell research and its translation to medicine.ISSCR StaffKeith Alm, Chief Executive OfficerShuangshuang Du, Scientific Programs ManagerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Senior Marketing ManagerJack Mosher, Scientific DirectorHunter Reed, Senior Marketing Coordinator 

Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.

Jessica and Harry from SomX explore three stories from the latest edition of the Healthtech Pigeon Newsletter.

The two lectures span human networks from neurons (Col 3) to nations (Mt 28) in discipleship…

The two lectures span human networks from neurons (Col 3) to nations (Mt 28) in discipleship…

In order to feel less stressed (and stop yelling), you've got to learn to understand and care for your nervous system. You'll Learn:The two parts of your nervous system and how they work togetherWhy managing your stress is so importantSignals that you're in a stress responseSome of my favorite mini stress resets (and where you can get a list of them for free)I'm zooming out to talk about the bigger picture of your entire central nervous system. And I'll show you how you can use your own nervous system to calm yourself more quickly.-------------------------------------------Your Nervous System ExplainedThere are two main parts of your nervous system. The first is your sympathetic nervous system. You might also have heard this talked about as your fight/flight/freeze/faint/fawn response). The second part is your parasympathetic nervous system, which includes the vagus nerve. The two parts work together to help you respond to stressful situations and then decrease that stress response, kinda like a teeter totter. One is activated at a time, while the other is decreased. Think of your nervous system as an information highway running through your body at all times. It takes in information through your senses and tells the brain how to respond to what you are experiencing. Neurons (brain cells) carry this message all throughout your body. If your brain interprets any of this information as dangerous, it triggers your stress response and activates the sympathetic nervous system. To your brain, a threat can be something like a kid spitting in your face or getting a bad grade or spilling juice all over the table. Stress juice floods your body, giving you the oomph to respond to the danger. When your stress response is activated, there is a period of time where you aren't able to regulate your nervous system. When that threat has passed, you start to come back online and your parasympathetic nervous system comes into play. The parasympathetic nervous system is your best friend when it comes to managing your stress response. It has its own network of nerves and helps relax your body after periods of stress or danger. It typically activates on its own after a stressor, but when we have triggers coming at us all the time (like in parenting life), it gets weakened and doesn't respond as well. That's why you need tools to reset the system on your own. When we talk about calm and taking pause breaks to reset, the parasympathetic nervous system is the piece that we're resetting. Chronic StressYour stress response is healthy and necessary. But often, our brains misinterpret things (like spilled juice being a life-or-death emergency). Parenting is a lot. What ends up happening is that you have a lot of demands and stressors coming at you one after the next, and you don't always have enough time to recover from them.This causes us to be chronically stressed. We constantly have stress juice pouring through our bodies, and it makes it really difficult to stay calm.This is what's going on when you find yourself getting angry and annoyed about every single thing your kid does. You've probably been in an activated stress response for a while, so you are dysregulated. As a mom, you're dealing with stressors all day long, especially if you have more than one kid. But there are little breaks in between.Our goal is to practice getting ourselves into the parasympathetic nervous system so that we can more easily recover from stress. We want that teeter totter to go easily up and down so that we flow smoothly between the two states of stress and non-stress. The way to do this is to...

Recorded by K. A. Hays for Poem-a-Day, a series produced by the Academy of American Poets. Published on January 29, 2026. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.poets.org⁠

Support the show to get full episodes, full archive, and join the Discord community. The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. Read more about our partnership. Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released. To explore more neuroscience news and perspectives, visit thetransmitter.org. Michael Shadlen is a professor of neuroscience in the Department of Neuroscience at Columbia University, where he's the principle investigator of the Shadlen Lab. If you study the neural basis of decision making, you already know Shadlen's extensive research, because you are constantly referring to it if you're not already in his lab doing the work. The name Shadlen adorns many many papers relating the behavior and neural activity during decision-making to mathematical models in the drift diffusion family of models. That's not the only work he is known for, As you may have gleaned from those little intro clips, Michael is with me today to discuss his account of what makes a thought conscious, in the hopes to inspire neuroscience research to eventually tackle the hard problem of consciousness - why and how we have subjective experience. But Mike's account isn't an account of just consciousness. It's an account of nonconscious thought and conscious thought, and how thoughts go from non-conscious to conscious His account is inspired by multiple sources and lines of reasoning. Partly, Shadlen refers to philosophical accounts of cognition by people like Marleau-Ponty and James Gibson, appreciating the embodied and ecological aspects of cognition. And much of his account derives from his own decades of research studying the neural basis of decision-making mostly using perceptual choice tasks where animals make eye movements to report their decisions. So we discuss some of that, including what we continue to learn about neurobiological, neurophysiological, and anatomical details of brains, and the possibility of AI consciousness, given Shadlen's account. Shadlen Lab. Twitter: @shadlen. Decision Making and Consciousness (Chapter in upcoming Principles of Neuroscience textbook). Talk: Decision Making as a Model of thought Read the transcript. 0:00 - Intro 7:05 - Overview of Mike's account 9:10 - Thought as interrogation 21:03 - Neurons and thoughts 27:05 - Why so many neurons? 36:21 - Evolution of Mike's thinking 39:48 - Marleau-Ponty, cognition, and meaning 44:54 - Naturalistic tasks 51:11 - Consciousness 58:01 - Martin Buber and relational consciousness 1:00:18 - Social and conscious phenomena correlated 1:04:17 - Function vs. nature of consciousness 1:06:05 - Did language evolve because of consciousness? 1:11:11 - Weak phenomenology and long-range feedback 1:22:02 - How does interrogation work in the brain? 1:26:18 - AI consciousness 1:35:49 - The hard problem of consciousness 1:39:34 - Meditation and flow

What if neurons aren't the foundation of mind? In this Mind-Body Solution Colloquia, Michael Levin and Robert Chis-Ciure challenge one of neuroscience's deepest assumptions: that cognition and intelligence are exclusive to brains and neurons.Drawing on cutting-edge work in bioelectricity, developmental biology, and philosophy of mind, this conversation explores how cells, tissues, and living systems exhibit goal-directed behavior, memory, and problem-solving — long before neurons ever appear.We explore: • Cognition without neurons• Bioelectric networks as control systems• Memory and learning beyond synapses• Morphogenesis as collective intelligence• Implications for AI, consciousness, and ethicsThis episode pushes neuroscience beyond the neuron, toward a deeper understanding of mind, life, and intelligence as continuous across scales.TIMESTAMPS:0:00 – Introduction: Why Neuroscience Must Go Beyond Neurons3:12 – The Central Claim: Cognition Is Not Exclusive to Brains7:05 – Defining Cognition, Intelligence, and Agency Without Neurons11:02 – Bioelectricity as a Control Layer for Morphogenesis15:08 – Cells as Problem-Solvers: Goals, Memory, and Error Correction19:41 – The Body as a Cognitive System: Scaling Intelligence Across Levels24:10 – Developmental Plasticity and Non-Neural Decision-Making28:36 – Morphological Computation and Collective Cellular Intelligence33:02 – Challenging Neuron-Centric Neuroscience Assumptions37:18 – Bioelectric Networks vs Neural Networks: Key Differences41:55 – Memory Without Synapses: Storing Information in Living Tissue46:07 – Rewriting Anatomy: Regeneration, Repatterning, and Control50:29 – Cancer, Developmental Errors, and Cognitive Breakdown54:48 – Pluribus: Philosophical Implications59:14 – From Cells to Selves: Where Does Agency Begin?1:03:22 – Implications for AI: Intelligence Without Brains or Neurons1:08:11 – Rethinking Consciousness: Gradualism vs Binary Models1:12:47 – Ethics of Expanding the Moral Circle Beyond Humans1:17:31 – Future Science: New Tools for a Post-Neuron Neuroscience1:22:54 – Closing Reflections: Life, Mind, and Intelligence All the Way DownEPISODE LINKS:- Cognition All the Way Down 2.0: Neuroscience Beyond Neurons in the Diverse Intelligence Era: https://link.springer.com/article/10.1007/s11229-025-05319-6- Robert's Publications: https://scholar.google.com/citations?user=7V9C7skAAAAJ&hl=en- Mike's Podcast 1: https://www.youtube.com/watch?v=v6gp-ORTBlU- Mike's Podcast 2: https://www.youtube.com/watch?v=kMxTS7eKkNM- Mike's Podcast 3: https://www.youtube.com/watch?v=1R-tdscgxu4- Mike's Podcast 4 (with Terrence Deacon): https://youtu.be/HuWbHwPZd60?si=z2unvX37OjXMjjIv- Mike's Lecture: https://www.youtube.com/watch?v=aQEX-twenkA- Mike's Channel: https://www.youtube.com/@drmichaellevin- Mike's Website: https://drmichaellevin.org/- Mike's Blog: https://thoughtforms.lifeCONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@mindbodysolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson's disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]

Today I'm joined by Dr Ewelina Kurtys, strategic advisor to FinalSpark, a company building computers powered by living human neurons.In simple terms, FinalSpark is exploring a new form of biocomputing that replaces silicon with real brain cells. This conversation dives into what that actually means, why it matters, and what it could unlock for the future of computation, energy efficiency, and AI.This is a genuinely mind-bending episode that sits at the intersection of neuroscience, computing, ethics, and deep tech innovation.Key Topics CoveredWhat FinalSpark is building and why biocomputing represents a radical shift from silicon-based systemsWhat drew Ewelina to FinalSpark's mission and long-term visionEarly challenges in building a biocomputing platform and how close the company is to true product-market fitFeedback from early users and adopters working with neuron-based computingThe biggest technical and operational hurdles to scaling living neuron infrastructureHow FinalSpark differentiates itself in the emerging biocomputing spaceThe company's long-term vision over the next 5 to 10 years and how it plans to fund and execute that roadmapWhy This Episode MattersBiocomputing is no longer science fiction. As traditional computing approaches physical and energy limits, FinalSpark is exploring an entirely new paradigm. This episode offers a rare, grounded look at what it really takes to turn breakthrough science into a commercial platform.

The atlas also offers up molecular and cellular targets for new pain therapies.

Send us a textA warm welcome today to emergency physician, Johnny Acheson, who is here to talk about his book, When Your Neurons Dance, which is a journey through Johnny's own diagnosis with Parkinson's disease at the age of 41. We explore some of the lessons that he has learned from lived experience of being a doctor, living and working with Parkinson's disease, thinking about the importance of exercise, community, support, education, It's a real eye opener as a book and one that I think we can all learn a huge amount from.

This is the audio version of a White Board Series.Video https://youtu.be/ocE0__RrTjM?si=oYsu4v4vyunt9RMDInsula and Salience Network https://youtu.be/XpzXkN-5ghA?si=0_3RKXe3C9aRZgERAutism & Salience Network on 6 weeks old https://youtu.be/_JQdir0V6Cg?si=pwJUzwv4BaspWluXFull Episode Spindle Neurons, Salience Network, & Social Behaviors https://youtu.be/FlPMVHnls-4?si=NyGyzrAknwVwNSGSFull Episode Autism and Adaptive Responses, and exploring the mPFC, ACC, and Insula https://youtu.be/Zj3_e6ZjCGk?si=VhHRN9HG5tJGKfcEFull Episode Autism and the Salience Network https://youtu.be/9ZbTztb3al8?si=WVv1txx39Y42l09bVon Economo neurons (VEN), sometimes called Spindle Neurons, are the brain's rare, giant ‘social superhighway' cells that let us make split-second intuitive judgments in complex social environments — and in autism these cells are significantly abnormal- some increased amounts in key brain hubs, some morphological impairments like altered soma, dendrite, or cytoarchitecture (remember microtubules for this role, too). These abnormal developed VENs are pulling the salience network toward raw sensory input instead of flexible social cognition.Daylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autismFig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com00:00 Spindle Neurons Introduction, Discovery, Species03:40 Brain Regions, Rapid Transmission, Neuropeptide Y07:20 Anterior Cingulate Cortex (ACC) Roles, Adaptive Responses11:00 Insula Functions, Salience Network Hubs14:40 Salience Network Nodes, Infant fMRI Study (UCLA 2024)18:20 Spindle vs Pyramidal Neuron Shape, Layer 5B Location22:00 Spindle Neurons in Autism, Lack of Adaptive ResponsesX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Neurons need particular sodium and potassium concentration gradients across their membranes to function. These gradients are set up by so-called ion pumps which require energy stored in ATP molecules to run. ATP is the common energy currency in the brain and is produced from nutrients delivered by the blood by a complicated set of chemical reactions known as a metabolic network. Today's guest has just published a comprehensive model of such a network and explains how it can shed light on differences between young and brains.

Ready to put your brain to the ultimate test?

This episode dives deep into excitatory neurons—the brain's primary “go” signal—and their outsized role in the autistic phenotype. We explore how pyramidal neurons, powered by glutamate through AMPA and NMDA receptors, drive lightning-fast information transmission, synaptic hyperplasticity via BDNF, and elevated gamma oscillations (30–80 Hz) in V1, S1, and A1. This overactive excitatory push, paired with reduced parvalbumin and somatostatin inhibition, creates the well-documented E:I imbalance that fuels sensory hypersensitivity, one-trial learning, rigid memory encoding, repetitive behaviors, and the classic distal-connection timing mismatch from early sensory cortices to prefrontal regions.The autistic brain gets to the first two stops blazingly fast yet struggles to reach the final destination typical brains arrive at effortlessly.Inhibition Episodes: https://youtu.be/cjwbog7Rk4c?si=uSaLLNmS5EJLa_iHhttps://youtu.be/Oee4L7Vsj4E?si=Y5F2eVudCLhkxNw1 https://youtu.be/PBHVssvoQkM?si=A6SPedQi-Dt-DVO_E/I https://youtu.be/ETChjRQ0SzQ?si=yIFNovzldwSZRMeThttps://youtu.be/jl0xwjnyXII?si=dmk49CMQo3Uf17axDaylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autismFig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com00:00 Excitatory Neurons, Push-Pull System, Parvalbumin Deficiency03:30 E:I Imbalance, Sensory Hypersensitivity, Repetitive Behaviors07:00 Pyramidal Neurons, Glutamate, AMPA/NMDA Receptors10:30 Brain Regions: DLPFC, Anterior Insula, V1 S1 A114:00 Amygdala Misnomer, Low Road vs High Road, Emotional Hub18:30 Receptors: AMPA 1-5ms, NMDA 10-200ms, mGluR Modulatory22:00 Gamma Oscillations, BDNF Hyperplasticity, Sensory Overload25:30 Distal Connections, Point-A-to-Point-B Timing Mismatch29:00 BDNF Critical Period, One-Trial Learning, Rigid Memory32:30 TRN Dysfunction, Repetitive Behaviors, Corticostriatal Circuit34:30 Go-Signal vs Stop-Signal, Push-Pull Bowling Bumpers36:00 Rubenstein & Merzenich 2003, E:I Imbalance Foundation37:08 Daylight Computer Company, use "autism" for $50 discount39:32 Chroma Light Devices, use "autism" for 10% discount42:35 Reviews/Ratings & Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this enlightening episode, I’m joined by Dr. Nathan Bryan to discuss the multifaceted role of nitric oxide in human health. Dr. Bryan, a pioneering scientist in nitric oxide research, offers an in-depth exploration of its function as a crucial signalling molecule, its impact on cardiovascular health, and its potential therapeutic applications for various diseases. Through this conversation, the importance of dietary choices, the dangers of common health misconceptions, and the power of simple lifestyle changes come to light. What You'll Learn: Origins and Discovery: Learn about the groundbreaking discovery of nitric oxide as a signalling molecule in the cardiovascular system, a discovery that earned its pioneers a Nobel Prize. Physiological Roles: Understand how nitric oxide functions as a neurotransmitter and its significance in long-term memory and nerve communication. Connection to Diet: Discover the vital relationship between dietary nitrates, nitric oxide production, and the importance of a healthy microbiome. Impact of Lifestyle Choices: Explore how lifestyle choices, like diet and oral hygiene practices, can profoundly affect nitric oxide production and overall health. Current and Future Research: Gain insight into Dr. Bryan’s ongoing research into nitric oxide-based therapies for diseases like Alzheimer's and cardiovascular issues. Key Takeaways: Diet and Health: Consuming a diet rich in green leafy vegetables can optimise nitric oxide production, supporting cardiovascular and immune health. Oral Hygiene: Antiseptic mouthwashes and fluoride toothpaste can disrupt the oral microbiome, negatively impacting nitric oxide production and raising blood pressure. The Microbiome's Role: A diverse and healthy microbiome supports nitric oxide production, critical for numerous bodily functions. Therapeutic Potential: Nitric oxide has the potential to revolutionise treatments for diseases like heart disease and Alzheimer’s. Holistic Health Approaches: Combining dietary changes, careful oral care, and appropriate supplements with conventional medical treatments can significantly enhance health outcomes. Resources Discover more through Dr. Nathan Bryan’s book, "The Secret of Nitric Oxide: Bringing the Science to Life," available at major retailers. Explore Dr. Bryan's educational videos on YouTube to deepen your understanding of nitric oxide and its health impacts. Connect with Dr. Bryan on LinkedIn for ongoing insights and information. Connect with Dr. Bryan on Instagram Website: https://n1o1.com/about-dr-nathan-bryan/ Through this conversation, Dr. Bryan reveals that understanding and optimising nitric oxide production can play a significant role in improving health outcomes. By making informed lifestyle choices and staying updated with scientific advances, we can harness this powerful molecule for better health and longevity. If you're interested in health innovation and the body's complex biochemistry, this discussion is a must-listen. Support the Podcast If you found this conversation enriching and beneficial, subscribe, rate, and review us on your favourite podcast platform. Your support spreads these essential dialogues, offering more individuals the opportunity to embark on their healing journeys. 01:53 Understanding Nitric Oxide: Basics and Discoveries 02:49 Nitric Oxide in the Cardiovascular System 08:28 Nitric Oxide's Role in the Immune System 10:33 Nitric Oxide in Neurons and Brain Health 16:37 Diet, Microbiome, and Nitric Oxide Production 31:49 Impact of Medications on Nitric Oxide Production 42:29 Optimising Nitric Oxide Through Diet and Supplements 46:15 The Impact of Dental Hygiene on Nitric Oxide Production 46:37 The Controversy of Fluoride in Water and Toothpaste 48:48 The Dangers of Antiseptic Mouthwash 53:06 The Benefits of Tongue Scraping 54:05 Optimising Nitric Oxide Through Lifestyle Practices 56:26 The Science of Photo biomodulation and Infrared Saunas 59:00 The Debate Between Traditional and Infrared Saunas 01:02:40 Morning Routine for Optimal Health 01:04:45 Scepticism Around Biohacking Supplements 01:12:02 Exciting Future of Nitric Oxide ResearchSee omnystudio.com/listener for privacy information.

Today's episode explores the role of inhibitory neurons & the Sonic Hedgehog (SHH) gene in shaping the Autistic phenotype, focusing on the excitation-inhibition imbalance that drives sensory hypersensitivity and cognitive challenges. Through a neuroscience lens, the episode connects these mechanisms to heightened gamma activity.Ben Ari Episode https://youtu.be/jo-ffwF9u0YParvalbumin Interneurons episode https://youtu.be/PBHVssvoQkM?si=t8WYGlcHcv7WiE-TVisual Thinking Part 1 https://youtu.be/XqQ8jCvWzYc?si=lffUEjGHjWj4mGOMNeurulation Part 1 https://youtu.be/gZdg9bX3Nuw?si=xvwtlz-p1hPHI8FADaylight Computer Company, use "autism" for $50 off athttps://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount athttps://getchroma.co/?ref=autismuse "autism" for 10% discount at Fig Tree Christian Golf Apparel & Accessories https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount athttps://thecognity.com00:00 - Autistic phenotype, excitation-inhibition imbalance, sensory hypersensitivity, cognitive deficits03:40 - Inhibitory neurons, GABA receptors, GABA-A, GABA-B, GABA-C, tonic inhibition07:24 - Tonic firing, burst firing, phasic firing, neural oscillations, sensory processing08:31 - Sonic Hedgehog gene, neural development, GABAergic identity, thalamic reticular nucleus (TRN)14:48 - Parvalbumin interneurons, fast-spiking, gamma oscillations, sensory gating, dorsolateral prefrontal cortex18:22 - Parvalbumin dysfunction, sensory hypersensitivity, visual cortex (V1), EI imbalance, brain-derived neurotrophic factor (BDNF)22:02 - Somatostatin interneurons, feedback inhibition, dendritic modulation, sensory adaptation, hippocampus25:43 - Vasoactive intestinal peptide (VIP) interneurons, disinhibition, pyramidal activity, attention, social processing29:30 - Calbindin interneurons, calretinin interneurons, dendritic inhibition, sensory processing, anterior insula33:15 - Purkinje cells, cerebellum, motor control, cognitive timing, cell loss in autism36:00 - Evolutionary perspective, parvalbium density, neural circuit stabilization, sensory-cognitive processing39:25 - Gamma activity, visual processing, retina, lateral geniculate nucleus, attention to detail, autistic self39:52 Daylight Computer Company, use "autism" for $50 discount42:13 Chroma Light Devices, use "autism" for 10% discount45:17 Reviews & Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

What if a nasal spray could switch off acute social anxiety in minutes—without systemic side effects?Shawn Singh, CEO of Vistagen, joins Fractals to explain how pherines work: odorless intranasal molecules that tap the olfactory pathway to flip specific brain circuits on and off.Highlights from the episode:How pherines activate the nose → olfactory bulb → targeted brain regions in milliseconds.Why fasadienol could be the first acute pharmacologic option for social anxiety disorder.The practical benefits of nasal-delivered treatment: on-demand use, fewer systemic risks, and new opportunities for people to engage in life (work, school, medical care).Real CEO lessons on resilience, trial design, and building teams that span science, regulatory, and operations.Tune into the full episode on your preferred podcast platform and contact Bracken to learn how we can support you from development through regulatory and commercial planning.

Emily is an Assistant Professor at MDI Biological Laboratory where she studies neurodegenerative disease-associated genes using super-resolution imaging of living, adult worms. Emily earned her Ph.D. at the University of Maine while embedded in the Jackson Laboratory and during her post-doc at MDI Bio Lab, she was recognized by the National Institutes of Health as an “Outstanding Scholar in Neuroscience”.This conversation was recorded in September 2025. ~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It is recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle. The Discover Maine theme was composed and performed by Nick Parker. To support our work: https://www.mainediscoverymuseum.org/donate. Find us online:Maine Discovery MuseumMaine Discovery Museum on social media: Facebook Instagram LinkedIn Bluesky Maine Science Festival on social media: Facebook Instagram LinkedInMaine Science Podcast on social media: Facebook Instagram © 2025 Maine Discovery Museum

Nociceptors tamp down the production of reactive oxygen species in response to heat, chemical irritants or toxins.

Join The Deep Dive (Life-changing teachings for spiritual mastery, guided sound journeys, and access to live community gatherings to share your most authentic self) ⁠https://iamemilioortiz.com/the-deep-d...⁠ In this powerful interview, Emilio Ortiz and Anne Tucker explore the activations and new energy transforming our planet and our lives. Anne channels angelic insights on the earth changes underway, describing how the Earth must crack open to allow light to enter and why humanity's role in witnessing this release is essential. Together they discuss the rise of self-awareness, the experience of loneliness in both humanity and the Earth, and how our thoughts and presence contribute to collective healing. This dialogue also reveals how we are moving beyond the karmic construct into a new earth shaped by unity, self-acceptance, and manifestation through presence. Anne describes the coming flash of light as a turning point that will awaken a higher octave of self, allowing us to co-create reality in alignment with our soul's truth. By embracing transformation, practicing self-love, and allowing what is, we become more dynamically open than ever before. Anne Tucker is healer & channel, supporting awakening souls on their journey through community, spiritual connection, and healing, so they can take advantage of this time of rapid growth and ascension. As a trance channel, Anne enters a meditative state where she connects to the Angelic realm and allows Angels to speak directly through her. She is a channel for Angelic guidance and healing frequencies that will prepare us and help to usher us through the planetary shift in consciousness. ___________________ Read Anne Tucker's book: What's Coming Next: A Channeled Guide to Navigating the Greatest Shift of our Time

Are you ready to explore the truth of human origins, evolution & consciousness from the perspective of universal beings so you can reclaim your true identity? Episode 146 of The Authentic Human Podcast is part 71 of The Story of Creation. Michelle Vickers invites you to explore the universal truth of human origins that have been strategically hidden from our collective memory. In this candid conversation with The Creator and Universal Beings, they reveal how universal communication (energy language) - the most ancient language in existence is the key to decoding the truth of human history and restoring the evolution of consciousness. You will discover: • How Michelle communicates with the Universal Beings who shaped existence to retrieve the true story of creation • Why modern systems are designed to trap us in classifications (labels, diagnoses, identities) • How the neurons in your brain communicate with your energy and vibrations revealing the higher truth of how they were designed to work for you. • The difference between living by society's rules and choosing universal truth • Why surrendering old belief systems (that comfy, stained sweater) is the doorway to freedom, joy, and peace This episode is for the truth seekers, for those who feel a deep pull toward spiritual awakening, for those who feel there must be more than what they've been told. You don't need to be an expert — you only need a curious heart and courage to question. Michelle shares universal level truth in simple, accessible terms so every human can reclaim the wisdom of their soul. She combines the best of both science and spirit — proving that the real history of humanity is encoded inside you and is accessible through universal communication, once we drop the lies. You're invited to step beyond the classification system into the fulfillment system. Stay curious. You are not alone. 0:00 Why The Story of Creation Matters 5:30 Neurons, Soul Energy & Universal Communication 8:49 Why Classification Limits You 12:12 Neuronal Vibrations & Universal Communication 15:43 Letting Go of the Comforting Beliefs 17:50 Overcoming Panic, Resistance & the Comfort Zone 20:26 Reclaiming Your Power Over Labels 24:06 Energy Moves, You Are Movement 28:11 Break Up with the Old To-Do List 📌 Subscribe to The Authentic Human Podcast to unlock more episodes of universal truth and cosmic discovery. Michelle Vickers is an explorer, researcher, and intuitive explorer bridging the deepest realms of consciousness and universal communication. She reveals how creation, existence, and human origins are encoded in you and they're all accessible through the universal language itself. Michelle translates that knowledge into simple terms so every human can access the truth of their soul, their purpose, and their connection to the universe. ________________________________________ #universaltruth #selfawareness #consciousness #humanorigins #universalperspective #spiritualawakening #spiritualawakening #ancientwisdom #hiddenknowledge #alchemy #spiritualdevelopment #higherconsciousness #spiritualpodcast #authentichuman #massawakening #quantumintelligence

Health technologist and science communicator Caitlin Shure (NextSense) joins me to unpack brainwave-measuring earbuds that can both read and change your mental state—starting with sleep.  We dive into why “Gen-1” wearables overwhelm you with charts but don't help you in the moment, how earbud-EEG works (yes, with just three electrodes), the messy truth on EMF fears, and why women—especially moms—need “do-it-for-me” tools, not just dashboards.  This episode is for women—especially busy moms and high-achievers—who want better sleep, calmer days, and science-backed wearables that actually help (not just track). WE TALK ABOUT:  05:00 - Caitlin's origin story: From “not a science person” to neuroscience and science communication 06:20 - Making complex brain science click for everyday life (and why wearables help) 09:55 - Why “one new idea at a time” beats info overload in health education 10:20 - Early neurotech (Muse), then Apple Watch, Oura, CGM—what worked and what didn't 13:20 - Why “wearable must be wearable”: Rings, watches, now earbuds near your brain 14:30 - Starting with sleep: The lowest-hanging lever for memory, mood, and cognition 19:40 - Neurons, synchrony, and how three earbud electrodes capture EEG 24:50 - Women's health use-cases: Pregnancy, postpartum, perimenopause, menopause 29:05 - “Numbers, not judgments”: Why NextSense won't label your sleep ‘good' or ‘bad' 34:30 - What's next: Adaptive Focus and Relaxation sessions (neurofeedback-like audio) 36:30 - Binaural beats: Mixed evidence, likely responders vs non-responders SPONSORS: CaloCurb (get 10% OFF) is my go-to, 100% plant-based alternative to Ozempic—helping you feel full sooner, snack less, and finally trust your body again without needles, drugs, or yo-yo diets. Join me in Costa Rica for Optimize Her, a 5-night luxury women's retreat in Costa Rica with yoga, healing rituals, and biohacking workshops—only 12 spots available. RESOURCES: Trying to conceive? Join my Baby Steps Course to optimize your fertility with biohacking. Free gift: Download my hormone-balancing, fertility-boosting chocolate recipe. Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. NextSense website and Instagram Caitlin Shure's website LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

My guest is Dr. Christof Koch, PhD, a pioneering researcher on the topic of consciousness, an investigator at the Allen Institute for Brain Science and the chief scientist at the Tiny Blue Dot Foundation. We discuss the neuroscience of consciousness—how it arises in our brain, how it shapes our identity and how we can modify and expand it. Dr. Koch explains how we all experience life through a unique “perception box,” which holds our beliefs, our memories and thus our biases about reality. We discuss how human consciousness is changed by meditation, non-sleep deep rest, psychedelics, dreams and virtual reality. We also discuss neuroplasticity (rewiring the brain), flow states and the ever-changing but also persistent aspect of the “collective consciousness” of humanity. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman BetterHelp: https://betterhelp.com/huberman Our Place: https://fromourplace.com/huberman Helix: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (0:00) Christof Koch (2:31) Consciousness; Self, Flow States (8:02) NSDR, Yoga Nidra, Liminal States; State of Being, Intelligence vs Consciousness (13:14) Sponsors: BetterHelp & Our Place (15:53) Self, Derealization, Psychedelics; Selflessness & Flow States (19:53) Transformative Experience, VR, Racism & Self; Perception Box, Bayesian Model (28:29) Oliver Sacks, Empathy & Animals (34:01) Changing Outlook on Life, Tool: Belief & Agency (37:48) Sponsors: AGZ by AG1 & Helix Sleep (40:23) Alcoholics Anonymous (AA) & Higher Power (42:09) Neurobiology of Consciousness; Accidents, Covert Consciousness (51:09) Non-Responsive State; Disability Bias, Will to Live, Resilience (55:34) Will to Live, Akinetic Mutism, Neural Correlates of Consciousness (57:43) Conflicting Perception Boxes, Meta Prior, Religion, AI (1:06:47) AI, Violence, Swapping Perception Boxes, Video (1:12:19) 5-MeO-DMT, Psychedelics, Light, Consciousness & Awe; Loss of Self (1:20:54) Death, Mystical Experience, Ocean Analogy; Physicalism & Observer (1:27:57) Sponsor: LMNT (1:29:29) Meditation, Tool: Spacetime Bridging; Ball-bearing Analogy; Digital Twin (1:36:16) Mental Health Decline, Social Media, Pandemic, Family & Play, Tool: Body-Awareness Exercises (1:41:34) Dog Breeds; Movement, Cognitive Flexibility & Longevity (1:47:17) Cynicism, Ketamine, Tool: Belief Effect; Heroes & Finding Flaws (1:52:46) Cynicism vs Curiosity, Compassion; Deaths of Despair, Mental Health Crisis (1:57:26) Jennifer Aniston, Recognition & Neurons; Grandmother Hypothesis (2:03:20) Book Recommendation; Meaning of Life (2:09:10) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, I discuss science-supported nutrients that directly support brain structure, function and long-term cognitive health. I highlight specific nutrients, including omega-3 fatty acids, creatine, phosphatidylserine, anthocyanins, choline and glutamine, and discuss their recommended doses and dietary sources. I also describe how taste perception, gut-brain signaling and learned associations shape what foods we prefer and crave. Finally, I share practical behavioral tools to help rewire your food preferences toward healthier choices. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Food & Brain Health 00:01:32 Structural Fat & Neurons, Tools: Omega-3s, EPA; Phosphatidylserine 00:05:11 Acetylcholine & Focus, Tool: Dietary Choline 00:06:48 Creatine & Brain Health, Tool: Creatine Supplementation 00:08:26 Sponsor: David 00:09:41 Anthocyanins & Brain Function, Tool: Blueberries & Berries 00:10:52 Glutamine & Brain, Tool: Glutamine & Offset Sugar Cravings 00:12:48 Brain-Boosting Nutrients, Foods & Supplements 00:15:03 Food Preference; Yum, Yuck or Meh; Mouth, Taste & Palatability 00:19:30 Gut, Nutrients & Subconscious Signaling 00:21:56 Learned Food Preferences 00:23:36 Sponsors: AGZ by AG1 & LMNT 00:26:16 Food & Learned Associations, Tool: Unpair Artificial Sweeteners 00:30:18 Belief Effects, Satiety, Tool: Rewiring Food Preferences 00:35:48 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

BASE64 Over DNS The base64 character set exceeds what is allowable in DNS. However, some implementations will work even with these invalid characters. https://isc.sans.edu/diary/BASE64%20Over%20DNS/32274 Google Chrome Update Google released an update for Google Chrome, addressing two vulnerabilities. One of the vulnerabilities is rated critical and may allow code execution. https://chromereleases.googleblog.com/2025/09/stable-channel-update-for-desktop_9.html Ivanti Updates Ivanti patched a number of vulnerabilities, several of them critical, across its product portfolio. https://forums.ivanti.com/s/article/September-Security-Advisory-Ivanti-Connect-Secure-Policy-Secure-ZTA-Gateways-and-Neurons-for-Secure-Access-Multiple-CVEs Sophos Patches Sophos resolved authentication bypass vulnerability in Sophos AP6 series wireless access point firmware (CVE-2025-10159) https://www.sophos.com/en-us/security-advisories/sophos-sa-20250909-ap6 Apple Introduces Memory Integrity Enforcement With the new hardware promoted in yesterday s event, Apple also introduced new memory integrity features based on this new hardware. https://security.apple.com/blog/memory-integrity-enforcement/

Support the show to get full episodes, full archive, and join the Discord community. The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. Read more about our partnership: https://www.thetransmitter.org/partners/ Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: https://www.thetransmitter.org/newsletters/ To explore more neuroscience news and perspectives, visit thetransmitter.org. What changes and what stays the same as you scale from single neurons up to local populations of neurons up to whole brains? How tuning parameters like the gain in some neural populations affects the dynamical and computational properties of the rest of the system. Those are the main questions my guests today discuss. Michael Breakspear is a professor of Systems Neuroscience and runs the Systems Neuroscience Group at the University of Newcastle in Australia. Mac Shine is back, he was here a few years ago. Mac runs the Shine Lab at the University of Sidney in Australia. Michael and Mac have been collaborating on the questions I mentioned above, using a systems approach to studying brains and cognition. The short summary of what they discovered in their first collaboration is that turning up or down the gain across broad networks of neurons in the brain affects integration - working together - and segregation - working apart. They map this gain modulation on to the ascending arousal pathway, in which the locus coeruleus projects widely throughout the brain distributing noradrenaline. At a certain sweet spot of gain, integration and segregation are balanced near a bifurcation point, near criticality, which maximizes properties that are good for cognition. In their recent collaboration, they used a coarse graining procedure inspired by physics to study the collective dynamics of various sizes of neural populations, going from single neurons to large populations of neurons. Here they found that despite different coding properties at different scales, there are also scale-free properties that suggest neural populations of all sizes, from single neurons to brains, can do cognitive stuff useful for the organism. And they found this is a conserved property across many different species, suggesting it's a universal principle of brain dynamics in general. So we discuss all that, but to get there we talk about what a systems approach to neuroscience is, how systems neuroscience has changed over the years, and how it has inspired the questions Michael and Mac ask. Breakspear: Systems Neuroscience Group. @DrBreaky. Shine: Shine Lab. @jmacshine. Related papers Dynamic models of large-scale brain activity Metastable brain waves The modulation of neural gain facilitates a transition between functional segregation and integration in the brain Multiscale Organization of Neuronal Activity Unifies Scale-Dependent Theories of Brain Function. The brain that controls itself. Metastability demystified — the foundational past, the pragmatic present and the promising future. Generation of surrogate brain maps preserving spatial autocorrelation through random rotation of geometric eigenmodes. Related episodes BI 212 John Beggs: Why Brains Seek the Edge of Chaos BI 216 Woodrow Shew and Keith Hengen: The Nature of Brain Criticality BI 121 Mac Shine: Systems Neurobiology 0:00 - Intro 4:28 - Neuroscience vs neurobiology 8:01 - Systems approach 26:52 - Physics for neuroscience 33:15 - Gain and bifurcation: earliest collaboration 55:32 - Multiscale organization 1:17:54 - Roadblocks

Professor Barbara Webb from the University of Edinburgh in Scotland​ uses physical robots to validate neural mechanisms in crickets, ants, and bees. In this episode of Brains and Machines, she talks to Dr. Sunny Bains of University College London about her work. Discussion follows with Dr. Giulia D'Angelo from the Czech Technical University in Prague and Professor Ralph Etienne-Cummings of Johns Hopkins University.

Neurons. Immune systems. MRIs. Weed gummies? One of the greats in neurology, Dr. Aaron Boster, takes time to chat all about Multiple Sclerosis, a neurological autoimmune disease close to our hearts. Alie's mom, your grammapod a.k.a. Fancy Nancy, was diagnosed with MS over two decades ago, and this episode explores in depth the factors that can cause MS, therapies that do – and don't –  show promise, how diet, exercise and mindfulness actually can help folks who have MS, the oftentimes agonizing journey to a diagnosis, and advice for those who've MS for a while – or are newly in the community. Also: yeah, weed. Visit the Boster Center for Multiple Sclerosis and follow Dr. Boster on YouTubeA donation went to MS Views and NewsMore episode sources and linksOther episodes you may enjoy: Disability Sociology (DISABILITY PRIDE), Diabetology (BLOOD SUGAR), Post-Viral Epidemiology (LONG COVID), Dolorology (PAIN), Salugenology (WHY HUMANS REQUIRE HOBBIES), Psychedeliology (HALLUCINOGENS), Cardiology (THE HEART), Somnology (SLEEP)400+ Ologies episodes sorted by topicSmologies (short, classroom-safe) episodesSponsors of OlogiesTranscripts and bleeped episodesBecome a patron of Ologies for as little as a buck a monthOlogiesMerch.com has hats, shirts, hoodies, totes!Follow Ologies on Instagram and BlueskyFollow Alie Ward on Instagram and TikTokEditing by Mercedes Maitland of Maitland Audio Productions and Jake ChaffeeManaging Director: Susan HaleScheduling Producer: Noel DilworthTranscripts by Aveline Malek Website by Kelly R. DwyerTheme song by Nick Thorburn

Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer's trials.In this episode, we discuss:How skin-derived cells can be turned into neurons to repair the brain.Why replacing lost neurons may succeed where drugs have failed in Alzheimer's.What makes autologous (self-derived) cell therapy safer and more effective.How testing in dogs brought stronger proof than traditional mouse models.Why this approach could shift Alzheimer's treatment from slowing decline to restoring memory.Credits:Created by Greg Kubin and Matias SerebrinskyHost: Matias Serebrinsky & Greg KubinProduced by Caitlin Ner & Nico V. Rey Find us at businesstrip.fm and psymed.venturesFollow us on Instagram and Twitter!Theme music by Dorian LoveAdditional Music: Distant Daze by Zack Frank

Dr. Ewelina Kurtys is leading the way in biocomputing at FinalSpark where she is working on the next evolutionary leap for AI and neuron-powered computing. It's a brave new world, just 10 years in the making. We discuss lab-grown human brain organoids connected to electrodes, the possibility to solve AI's massive energy consumption challenge, post-silicon approach to computing, biological vs quantum physics and more.

In this Huberman Lab Essentials episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity. I discuss both the hardwired mechanisms and subjective factors that shape an individual's perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Pain & Pleasure 00:00:39 Skin, Appetitive vs Aversive Behaviors 00:02:10 Skin, Neurons & Brain 00:04:46 Brain Interpretation, Homunculus, Two-Point Discrimination Test 00:07:43 Pain & Pleasure, Subjective Interpretation 00:09:53 Sponsor: AG1 00:11:30 Tool: Pain & Expectation 00:13:08 Pain Threshold 00:14:46 Heat & Cold, Tool: Moving into Cold or Hot Environments 00:16:37 Subjective Pain, Psychosomatic, Fibromyalgia, Whole Body Pain, Acetyl-L-carnitine 00:20:54 Acupuncture, Electroacupuncture, Pain Management 00:23:44 Sponsors: LMNT & Eight Sleep 00:26:36 Red Heads & Pain Threshold, Endorphins 00:28:32 Improving Pain Threshold, Dopamine 00:30:00 Pleasure, Dopamine, Serotonin; Depression, Anti-depressants 00:34:12 Pleasure & Pain Balance, Dopamine, Addiction 00:36:08 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Huberman Lab Essentials episode, I explain how to build endurance and describe targeted protocols to enhance different types of endurance. I discuss how endurance—the ability to sustain effort—requires the coordination of physical and mental systems driven by energy availability, brain willpower, and specific training adaptations in the muscles, heart, lungs and neurons. I explain conditioning protocols designed to enhance four types of endurance, from long-duration steady state to muscular endurance and high-intensity intervals, and how each training style triggers unique adaptations in the body and brain, such as improved mitochondrial function and oxygen utilization. Additionally, I highlight the crucial role of hydration and electrolytes, which are essential for neural function and influence the brain's willpower to sustain effort. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Follow Huberman Lab Instagram Threads X Facebook TikTok LinkedIn Timestamps 00:00:00 Huberman Lab Essentials; Build Endurance 00:00:50 Energy Sources, ATP, Oxygen 00:04:14 Neurons & Willpower, Glucose & Electrolytes 00:09:19 Heart, Lungs; Physiology & Performance Limiting Factors 00:10:35 Sponsor: AG1 00:12:30 Muscular Endurance, Protocol, Concentric Movements, Mitochondria 00:19:10 Sponsors: LMNT & Eight Sleep 00:22:00 Long-Duration Endurance, Efficiency, Mitochondria, Capillaries 00:25:54 High-Intensity Interval Training (HIIT), Anaerobic Endurance, Protocol 00:32:33 High-Intensity Aerobic Endurance, Adaptations 00:35:30 Sponsor: Function 00:37:26 Brain & Body Adaptations, Heart 00:40:40 Hydration, Tool: Galpin Equation 00:42:21 Supplements, Stimulants, Magnesium Malate 00:43:11 Recap & Key Takeaways Disclaimer & Disclosures