Podcasts about Parkinson

Hosts Kevin Palmieri and Alan Lazaros break down why “not having enough time” is one of the most common excuses holding ambitious people back. They explain how poor structure, loose deadlines, and unclear standards quietly undermine productivity, focus, and long-term growth. Drawing from years of coaching, business building, and thousands of conversations with high performers, they challenge the belief that more time automatically leads to better results.This episode explores how discipline, intentional constraints, and clear finish lines create momentum, confidence, and consistency in life, health, business, and relationships. If you are tired of feeling behind and ready to operate with greater precision and personal authority, this conversation will reshape how you think about time._______________________Learn more about:Track the Work. Earn the Results. 10 Pounds in 10 Weeks Challenge. To know more about the Next Level Fitness Accountability Group or get directly connected via Instagram:Kevin: https://www.instagram.com/neverquitkid/Alan: https://www.instagram.com/alazaros88/Join our Next Level University Monthly Masterclass, "Setting Your Life up for the Most Productive Year You've Ever Had." One hour. Real principles. Lasting breakthroughs - https://us06web.zoom.us/meeting/register/nOyQhYF9TOaUdO1ezDdfdA#/registrationYour first 30-minute “Business Breakthrough Session” call with Alan is FREE. This call is designed to help you identify bottlenecks and build a clear plan for your next level. - https://calendly.com/alanlazaros/30-minute-breakthrough-session_______________________NLU is not just a podcast; it's a gateway to a wealth of resources designed to help you achieve your goals and dreams. From our Next Level Dreamliner to our Group Coaching, we offer a variety of tools and communities to support your personal development journey.For more information, check out our website and socials using the links below.

If certain windsurfing former Judges are to be believed, there's nothing quite like a bout of vigorous exercise for easing the symptoms of Parkinson's. But does the medical evidence support this? Cramped into their booth in the Notting Hill pub, the Movers & Shakers pick over the verifiable scientific facts behind the assumption that exercise can alleviate PD symptoms. Is it possible to fairly analyse the impact of exercise? Could the effect be more psychological than physical? And might exercise, one day, be prescribed by your neurologist? We're discussing all this (and more) with top experts and the gang.Movers & Shakers is brought to you by Cure Parkinson's.Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.Produced and edited by Nick Hilton for Podot.Sound mixing by Ewan Cameron.Music by Alex Stobbs. Hosted on Acast. See acast.com/privacy for more information.

Send us a textForget the assumption that modern neurology only thrives where resources are abundant. We sit down with Dr. Daniel Ontaneda and Dr. Nelson Maldonado—two Ecuadorian neurologists driving change across Latin America—to explore how world-class care is built on clinical craft, cultural fluency, and relentless advocacy. From bedside localization when the MRI is down to expanding stroke thrombolysis from a handful of cases to hundreds, their stories reveal a system where expertise is abundant but access can lag—and how that gap is closing.We retrace Dan's journey from Quito to leading-edge MS research, and Nelson's decision to return home to build services few believed possible. Together they unpack what training looks like across the region, including long-format medical school, rural service, and residencies that demand deep exam skills. We compare public and private systems in Ecuador, break down why patients often want clear directives rather than options, and examine how cultural beliefs and language shape adherence. The conversation digs into MS treatment in low- and middle-resource settings, the rise of highly effective disease-modifying therapies, and the pragmatic use of cost-effective options like rituximab.The episode also exposes a hidden threat: substandard medications entering through price-first procurement, undermining both acute care and chronic neurologic disease. Yet the momentum is real—regional MS registries, imaging collaborations that move faster than heavily regulated systems, and conferences that bring neurocritical care and MS experts under one roof. Even subspecialists practice broadly, treating Parkinson's disease, epilepsy, headache, and ICU cases in the same week, sharpening an exam-first mindset that delivers results.If you care about global neurology, stroke systems of care, MS access, and the practical ethics of delivering evidence-based treatment under constraints, this conversation will challenge assumptions and spark ideas. Subscribe, share with a colleague, and leave a review telling us where neurology should invest next.Support the showHosts:Dr. Nupur Goel is a third-year neurology resident at Mass General Brigham in Boston, MA. Follow Dr. Nupur Goel on Twitter @mdgoels Dr. Blake Buletko is a vascular neurologist and program director of the Adult Neurology Residency Program at the Cleveland Clinic in Cleveland, OH. Follow Dr. Blake Buletko on Twitter @blakebuletko Follow the Neurophilia Podcast on Twitter and Instagram @NeurophiliaPod

Can specific gut and mouth bacteria influence brain health and conditions like Parkinson's or Alzheimer's? We look at early clinical work on Lactobacillus plantarum PS128 and its potential to slow Parkinson's progression, links between gum disease and dementia, and how Lactobacillus reuteri may stimulate oxytocin. This clip explores the gut-brain and oral-brain connections, the idea of a brain microbiome, and emerging views on brain regeneration and healthy aging. ***This episode is sponsored by:NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at https://nowatch.com/Mojo: the app for expert-led courses in better sex.Learn from world-class sex therapists and relationship experts with courses tailored to your needs.15% off with code LiveWell15 at mymojo.com/livewellbewell***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.

Des préliminaires tout en musique, deux vieux dans un bistrot qui hésitent entre avoir Alzheimer et Parkinson, et deux belges qui regardent la télévision... Découvrez les 3 histoires drôles du jour ! Tous les jours, en podcast, retrouvez une compilation des meilleures blagues de vos Grosses Têtes préférées.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

What if two people saved the exact same amount of money... but one retired with nearly $900,000 more than the other? The difference wasn't discipline — it was where the money lived. In this episode of Without the Bank, we break down one of the most powerful chapters from Becoming Your Own Banker: The Twin Sister Example. Using Nelson Nash's comparison between CDs and Infinite Banking, we examine how capitalization, dividends, and ownership significantly impact long-term outcomes. We also tackle one of the most misunderstood — and ignored — components of Infinite Banking: the death benefit. Many people focus only on early cash value, but real banking strategies account for protection, longevity, and uninterrupted compounding. If you've ever wondered why Infinite Banking outperforms traditional savings, CDs, and even "paying cash," this episode connects the dots. Key Takeaways: Why capitalization is unavoidable — no matter how you finance purchases How leasing, bank loans, cash, CDs, and Infinite Banking really compare The hidden cost of "paying cash" and sinking funds Why the death benefit is not a downside — it's a bonus How ownership and dividends change retirement income forever Why Infinite Banking allows income without running out of money Chapters: (00:00) – Why the death benefit matters more than people think (01:09) – Why starting small beats radical lifestyle changes (02:25) – Comparing car financing: lease, bank, cash, CD, IBC (08:38) – CDs vs Infinite Banking: the Twin Sister example (12:55) – Why dividends change everything long-term (16:13) – Retirement income: why one sister runs out and the other doesn't (27:32) – The two rules of Infinite Banking you must follow Get Started: Ready to build your own banking system? Email: maryjo@withoutthebank.com Email: tarisa@withoutthebank.com Grab your copy of Becoming Your Own Banker: https://www.withoutthebank.com/shop... Schedule an appointment and start beating Parkinson's Law today!

Brant Peterson, Vice President & Fellow at Valo Health, joins Data in Biotech to explore how his team leverages real-world data, genetic insights, and machine learning to de-risk drug discovery. From building causal DAGs to identifying patient subtypes in neurodegenerative diseases like Parkinson's, this episode dives deep into a patient-first, data-driven approach to biomedical innovation. What You'll Learn in This Episode: >> How Valo Health uses real-world evidence and EHR data to prioritize drug targets earlier in the development pipeline. >> Why integrating wet lab experiments and causal DAGs accelerates therapeutic validation. >> The importance of genetic pleiotropy and Mendelian randomization in refining disease hypotheses. >> How Valo Health identifies high-impact patient subgroups in neurodegenerative diseases like Parkinson's and Alzheimer's. >> Where machine learning models succeed and fall short, in uncovering mechanisms of disease from sparse longitudinal data. Meet Our Guest Brant Peterson is Vice President & Fellow in Data Science at Valo Health. He brings deep expertise in genetics, computational biology, and biomedical innovation. Formerly a Distinguished Data Scientist at Valo and Computational Biologist at Novartis, Brant focuses on leveraging patient-centric data to drive causal discovery in drug development. About The Host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancyConnect with Brant Peterson on LinkedIn  Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science.Subscribe and leave a review if you enjoyed this episode!Connect with Ross Katz on LinkedIn Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn.

(airdate: 01.29.26) Michael J. Fox opens up about living with Parkinson's, pushing for more government support for brain research, and sharing emotional scenes with Harrison Ford on Shrinking (Apple TV+). Plus, Ryan Reynolds is reportedly eyeing a return to Deadpool mode as he looks to reset his public image and get back into the role fans love most. Voted 6th Best Entertainment News Podcast! Because being #1 is soooo overrated. And @HalleBerry Listen to the daily Van Camp and Morgan radio show at: https://vancampandmorgan.com/stations buy us a coffee    

Many medications ease the constellation of symptoms that define Parkinson's disease, but the only treatment that slows the progression of the neurological movement disorder can't be purchased at a pharmacy. It's high-intensity, cardiovascular exercise, like boxing, and it's changing lives.

No stranger to the WBZ NewsRadio airwaves, longtime radio broadcaster Jordan Rich joined us this to discuss his latest book written about him, along with the author John A. DiCicco of "Jordan's Rich Journey: A Path of Purpose, Strength, and Hope with Parkinson's." As many listeners know, Jordan was diagnosed with Parkinson’s disease a couple of years ago. Jordan took listeners calls about not just his life with Parkinson’s but about his extensive career in broadcasting. See omnystudio.com/listener for privacy information.

In part one of this four-part series, Casey Kozak breaks down tremors observed during the physical examination of FND.  Show transcript:  Casey Kozak: Welcome back to Neurology Minute. This is Casey Kozak with Rutgers, and today we'll be discussing a very important and evolving topic, that is Functional Neurological Disorder, or FND. If you're a regular fan of the Minute, you'll have already heard a great miniseries on FND by Jon Stone and Gabriela Gilmour, which focuses on diagnosis and treatment. If you haven't listened yet, I encourage you to check it out. In this series, we're going to focus in on physical exam findings associated with FND to help you excel on the floors. Talking about the physical exam, it's important to keep in mind that FND looks different for every patient. However, some general characteristics of symptoms may include inconsistency, variability, selectivity of impairment, meaning mismatch of impairment with different tasks, distractibility, suggestibility, and incongruence with symptoms seen in other neurological disorders. Since tremors are one of the most common presentations of FND, we'll start there. Even while taking their history, you may notice features consistent with FND. And in fact, this is a great time to make natural observations of the patient and their symptoms. Unlike tremors associated with degenerative movement disorders like Parkinson's, functional tremors may exhibit variability of frequency and amplitude, especially during periods of shifted attention. You can further evaluate the tremor using the entrainment test. To perform the entrainment test, ask the patient to make a tapping motion. As the patient taps, look for a change in frequency in their tremor. The frequency of the tremor may begin to match the frequency of the patient's tapping. Any change in the tremor while the patient is tapping is considered a positive finding. Alternatively, you can also test the whack-a-mole sign. To elicit the whack-a-mole sign, the examiner holds down the tremulous body part while looking for the emergence of a tremor in a different body part. This finding is consistent with a functional tremor, as tremors related to neurodegenerative diseases do not jump limbs. Let's break now to practice. Join us again for our next episode where we will turn to functional weakness. See you then.

Do you have trouble sleeping? It's a topic you can't avoid once you reach a certain age. And while sleep problems are common in people with Parkinson's disease, they certainly aren't limited to them. Because of that, treatment is often the same as it is for anyone else. Until researchers uncover more specific biological causes in Parkinson's—progress is being made—we rely on standard, evidence-based treatments for insomnia. In this episode, we speak with an expert about one such treatment: a non-medication approach called Cognitive Behavioral Therapy for Insomnia, or CBT-I. It helped me tremendously, and I hope you'll listen. It may be something you want to try. https://cbti.directory/ Thank you to our sponsor – Boston Scientific, the maker of Vercise Genus, a Deep Brain Stimulation or DBS system. To learn more about the latest treatment options for Parkinson's disease at https://DBSandMe.com/17branches   

Stress isn't just a feeling—it's your body mobilizing resources to meet a moment. We sit down with a neuropsychologist to map what stress actually is, how it differs from anxiety, and why chronic activation can make the “on” switch hypersensitive and the “off” switch hard to hit. From there, we wade into depression and apathy in Parkinson's—two experiences that look similar from the outside but feel very different inside—and why apathy in particular is tough on families and tricky to treat.We compare roles on the care team—psychiatry for medications, psychology and neuropsychology for therapy and assessment—and talk about why a blended plan often works best. For those navigating young-onset Parkinson's, we get real about career pressure, parenting, and socially demanding hobbies, and we offer scripts for advocating needs without withdrawing. Hiding symptoms hands the disease more than it took; a single text that asks “What would you like to do with us?” can change the week.You'll leave with practical tools you can use today: exposure therapy to unlearn avoidance, mindfulness that's grounded in sensory cues, and progressive muscle relaxation to pull the only two voluntary levers you have in the stress response—breath and muscles. We round it out with the habits that build resilience—sleep, movement within your limits, honest conversations, and small daily acts of joy—and with the bigger question that shapes recovery: who am I now, and who can I become with this diagnosis?If this conversation landed with you, follow the show, share it with a friend who needs it, and leave a rating or review so more people can find it. Your voice helps this community grow. Co-hosts: Judy Yaras & Travis Robinson www.INDYpodcast.net

Dysphagia in Parkinson's disease is not one-size-fits-all, and treatment decisions shouldn't be either.In this episode of Swallow Your Pride, Theresa is joined by PD Dr. Bendix Labeit, MBA, neurologist and clinician-scientist, and Jule Hofacker, MSc, speech-language pathologist and PhD student in neurogenic dysphagia, to explore how Parkinson's treatments impact swallowing. They discuss how dopaminergic medication […] The post 388 – Parkinson's, Swallowing, and Deep Brain Stimulation: What Clinicians Need to Know appeared first on Swallow Your Pride Podcast.

Dr. Margarita Fedorova discusses possible environmental exposures and their risk of Parkinson disease.  Show citation:  Dorsey ER, De Miranda BR, Hussain S, et al. Environmental toxicants and Parkinson's disease: recent evidence, risks, and prevention opportunities. Lancet Neurol. 2025;24(11):976-986. doi:10.1016/S1474-4422(25)00287-X  Show transcript:  Dr. Margarita Fedorova: Welcome to Neurology Minute. My name is Margarita Fedorova and I'm a neurology resident at the Cleveland Clinic. Today, we're reviewing some information about possible environmental exposures and their risk of Parkinson disease. As we see in diagnose patients with Parkinson, they often want to know why they developed it and some emerging studies may offer insights. A recent personal view published in The Lancet Neurology by Ray Dorsey and colleagues in November 2025 examined associations between three environmental exposures and Parkinson's disease; pesticides, dry cleaning chemicals and air pollution. Since only five to 15% of Parkinson's cases have an identifiable genetic cause, environmental factors are an important area of investigation. Dorsey and colleagues describe studies showing that pesticide exposure is associated with Parkinson's risk. One example is Paraquat, an herbicide widely used in agriculture. It's banned in over 30 countries, but remains legal in the United States. In a population-based US study, residents living or working near areas where Paraquat was sprayed at twice the risk of developing Parkinson's, suggesting residential proximity alone may confer risk. Other pesticide exposures may show similar patterns. The organic chlorides, DGT and gildren are used in various agricultural areas. They're fat-soluble compounds that accumulate over decades. Postmortem studies found that when brains with lewd pathology and some studies suggest developmental exposure may increase risk of neurodegeneration years later. There have also been risks possibly associated with chemicals used in dry cleaning and metal degreasing. Trichloroethylene or TCE is one such chemical that was found in high amounts in the water at Camp Lejeune in North Carolina. A study of over 170,000 marines stationed there showed a 70% increase in risk of developing Parkinson's compared to marines at a non-contaminated base. What's particularly striking is the timing. Marines were exposed at an average age of 20 and the exposure lasted just over two years, yet disease manifested 34 years later. This suggests a long latency period between exposure and disease onset. TCE is also concerning because it evaporates from contaminated groundwater and can seep into buildings. As of 2000, 30% of US groundwater was contaminated with TCE. The third category of environmental exposure is air pollution. Studies from Canada, South Korea, Taiwan, and the UK show association between exposure to fine particular matter known as PM 2.5 in nitrogen dioxide with increased Parkinson's risk. These pollutants come from vehicle emissions, industrial sources, and combustion processes. The studies suggest that chronic exposure to these air pollutants may contribute to neurodegeneration through inflammatory and oxidative stress mechanisms. Unlike pesticides and dry cleaning chemicals, the magnitude of increased risk is often modest, typically ranging from one to 20%. However, the potential impact at large since almost everyone worldwide, 99% of people breathe on healthy air. For us as clinicians, this underscores the importance of taking detailed environmental histories. When patients ask, "Why me?" We can acknowledge that environmental exposures may have contributed to their disease. It's important to note that these studies show associations, but they don't confirm clear causation. Regardless, they may provide some answers to patients asking about the etiology of their Parkinson's or even the risks to others. That's your neurology minute for today. Keep exploring and we'll see you next time. If you want to read more, please find the paper by Ray Dorsey, titled Environmental Toxicants and Parkinson's Disease: Recent Evidence and Prevention Opportunities, published online in The Lancet Neurology in November 2025.

In this episode, hosts Erin Gallardo, PT, DPT, NCS and Claire McLean, PT, DPT, NCS discuss a new research article, "Refining maximal heart rate estimation to enhance exercise recommendations for persons with Parkinson's disease." Parkinson's is a multi-system condition and changes to the function of the autonomic nervous system are common. At times this can present as a person with PD having trouble reaching aerobic heart rate zones calculated based on age while they're performing high intensity exercise. Claire explains the challenges they've faced using standard heart rate formulas and color-zoned monitoring apps when many clients appear stuck in a "gray zone," likely due to this autonomic dysfunction and chronotropic incompetence common in Parkinson's. After exploring but struggling to access cardiopulmonary exercise testing (CPET)—the gold standard for determining true maximal heart rate—Claire finds this new study, which uses CPET data from a cycling trial to derive a more accurate regression-based equation for people with Parkinson's: 166 − (1.15 × age) + (0.60 × resting heart rate). She describes how they are now applying this formula in practice by calculating individualized max heart rates, manually updating values in their OnBeat app, and offering a public calculator via their website so people with Parkinson's and clinicians can easily generate appropriate training zones. This shift should make target zones more realistic, motivating, and safer. Listen to the show to easily incorporate this research into your practice today!   Pull up the article here (free full text available): https://pubmed.ncbi.nlm.nih.gov/40194736/ Use Claire's calculator that uses the research-based formula here: https://www.roguept.com/cardio

We go from laser-beam shenanigans and comic book hot takes to a practical, no-fluff playbook for managing time at work. A simple framework, clear constraints, and better negotiations turn chaos into momentum and make you look reliably in control.• three-answer intake for new requests: yes now, yes later with a date, or no• clarifying questions that set purpose, deadline, and success• Parkinson's Law and the cheap, good, fast trade-off• stakeholder time negotiations and priority mediation• manager alignment by sharing your active stack for reprioritization• scope to time: match quality to constraints without guilt• email triage, batch processing, and protecting deep work• reputation benefits of reliability over busynessJoin the Discord via the Linktree in the show notes to vote on Bruce's hero or villain arc and learn about our totally real time travel plan. Also: “Buy us a coffee” via the Linktree to support the showClick/Tap HERE for everything Corporate StrategyElevator Music by Julian Avila Promoted by MrSnoozeDon't forget ⭐⭐⭐⭐⭐ it helps!

How does research into Parkinson's and Alzheimer's overlap, and what insights are being revealed? Tune into audio from this month's Third Thursdays Webinar to hear our panel of experts discuss what scientists are learning about how these diseases affect the brain and how understanding their links may lead to better care for people living with a disease.Like our podcasts? Please consider leaving a rating or review and sharing the series with your community. https://apple.co/3p02Jw0Whether you have Parkinson's or not, you can help move research forward. Join the study that's changing everything at michaeljfox.org/podcast-ppmiMentioned in this episode:The Foundation's landmark research study is exploring the connection between sense of smell and brain disease. People with and without Parkinson's can help by taking a free scratch-and-sniff test. Get yours at mysmelltest.org/request.

In this episode, Dr. Alexander Lehn explores the clinical management of Parkinson's disease across the reproductive journey; before conception, during pregnancy, and in the postpartum period. He shares the current evidence, practical challenges, medication safety considerations, and multidisciplinary decision-making. The conversation highlights gaps in data, real-world clinical strategies, and key counseling points to support optimal outcomes for both the parent and child. Read the article.

Cardiologist Bob Harrington talks to Mitch Elkind, chief science officer for Brain Health and Stroke at the AHA, about the heart-brain connection and why what's good for the brain is good for the heart. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association  https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078 Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546 Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands https://doi.org/10.1080/13814788.2017.1398318 Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study https://doi.org/10.1002/epd2.20253 Traumatic Brain Injury and Risk of Neurodegenerative Disorder https://doi.org/10.1016/j.biopsych.2021.05.025 Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence https://doi.org/10.3390/ijms222413488 The neuropathological diagnosis of Alzheimer's disease https://doi.org/10.1186/s13024-019-0333-5 Failed Semaglutide for Early Alzheimer's Not the End of the Road? https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration https://doi.org/10.1161/circulationaha.121.055018 Reduced regional cerebral blood flow in patients with heart failure https://doi.org/10.1002/ejhf.874 Heart-brain Interactions in Heart Failure https://doi.org/10.15420/cfr.2018.14.2 While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder https://doi.org/10.1001/jamapsychiatry.2024.3599 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356 "VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593 Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299 Unlocking Longevity: Aging Reimagined  https://www.medscape.com/viewarticle/1002241 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Jeffrey Weissman, over ninety film and television, and over one hundred stage credits. On television, he guest stars on Diagnosis Murder, Scarecrow & Mrs King, Saved By the Bell, Max Headroom, and othersHe co-stars in Back to the Future II & III (as George McFly), Pale Rider, Twilight Zone the Movie, most recently in No Address, Siblings and as Professor James Moriarty in Sherlock Holmes and the True Believer.Jeffrey is an advocate, and fundraiser for many charities; The Michael J. Fox Foundation for Parkinson's Research, American Heart Association, National Brain Tumor Foundation, Make A Wish Foundation, The Coalition on Homelessness, The Source's 'Dignity Bus' and many more.

A typical vaccine stimulates a person's immune system, yet only a portion of the immune response actually targets the disease it's designed to protect against. However, a new technology may be changing that dynamic.In this episode, I sit down with Lou Reese, an entrepreneur who has led or co-founded several biotech companies and has been working on synthetic peptide-based active immunotherapy medicines. He's co-CEO of United Biomedical and co-founder of Vaxxinity, Cana Life, and Axxium.He's working on a product that could—if proven successful—transform our approach to treating and preventing Alzheimer's. He and his team also have a product that has shown preliminary promise in phase 1 trials in treating Parkinson's.In this episode, he also reveals an incredible story: He and his team previously developed a peptide-based active immunotherapy vaccine candidate for COVID-19, and they successfully completed Phase 1 and Phase 2 trials. Institutional backing, however, favored Pfizer and Moderna. In 2022, Lou Reese's team was invited to the White House “Summit on the Future of COVID‑19 Vaccines,” where they presented their candidate as an alternative to Pfizer's mRNA vaccine, which by then had been associated with serious side effects.In the end, their product was never approved, and related content on YouTube was marked as misinformation.Views expressed in this video are opinions of the host and the guest, and do not necessarily reflect the views of The Epoch Times.

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3268: Dr. Neal Malik breaks down the health risks of sugar-free energy drinks, pointing to concerns beyond just sugar, such as unregulated additives and potential links to heart and liver issues. He explains why switching to plain coffee is likely the safer, more beneficial choice for daily caffeine. Quotes to ponder: "Most health experts agree that the issue with energy drinks isn't necessarily their caffeine, but the amount of added sugar they contain as well as some of the other added ingredients." "Extra L-carnitine can increase a person's risk of developing cardiovascular disease." "Three to four cups of plain coffee consumed each day may protect against type 2 diabetes, colon cancer, liver cancer, Parkinson's disease, and even cardiovascular disease." Learn more about your ad choices. Visit megaphone.fm/adchoices

Is life insurance a luxury—or a necessity? In this episode of Farming Without The Bank (FWTB Ep. 338), Mary Jo breaks down Chapter 7 of Nelson Nash's Warehouse of Wealth and explains how Parkinson's Law silently destroys financial progress, especially when people experience windfalls of money. From selling land, paying off equipment, kids leaving the house, or daycare expenses disappearing—windfalls happen whether you notice them or not. The real question is: Where does that money go? Nelson Nash's real-life example shows how paying off a policy loan after a windfall can feel like backdating life insurance by 13 years at a better health rating—an advantage you can never recreate later. This episode challenges the belief that life insurance is optional and explains why end-of-life benefits and banking should be treated like fuel in a vehicle—non-negotiable. Key Takeaways: Why Parkinson's Law eats every "extra dollar" if you don't give it a job How windfalls (kids moving out, loans paid off, daycare ending) should be redirected Why delaying a policy creates massive inefficiencies later in life Why the end of life benefit for children is about time to mourn, not profit How farmers and ranchers must be in the business of banking, not just production Chapters: (00:00) – Life Insurance: Luxury or Necessity? (01:07) – Nelson Nash's Windfall & Backdated Advantage (03:10) – Kids Leaving Home = Hidden Windfall (04:42) – Parkinson's Law Explained (08:04) – Daycare, Sports & Missed Opportunities (09:43) – Death Benefit Is Non-Negotiable (12:29) – Building Banking Into Your Commodity Price

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3268: Dr. Neal Malik breaks down the health risks of sugar-free energy drinks, pointing to concerns beyond just sugar, such as unregulated additives and potential links to heart and liver issues. He explains why switching to plain coffee is likely the safer, more beneficial choice for daily caffeine. Quotes to ponder: "Most health experts agree that the issue with energy drinks isn't necessarily their caffeine, but the amount of added sugar they contain as well as some of the other added ingredients." "Extra L-carnitine can increase a person's risk of developing cardiovascular disease." "Three to four cups of plain coffee consumed each day may protect against type 2 diabetes, colon cancer, liver cancer, Parkinson's disease, and even cardiovascular disease." Learn more about your ad choices. Visit megaphone.fm/adchoices

In this important and timely presentation on "The Effects of Toxins on Mental Health," naturopathic physician and environmental medicine pioneer Dr Joe Pizzorno reveals how the global rise in mental health disorders parallels a dramatic increase in human exposure to toxic chemicals. He explains that toxins now permeate our food, water, air, household environments, and even medical care – while the nutrients that once protected us from these chemicals have simultaneously declined in the modern diet. This combination, he shows, has created ideal conditions for brain dysfunction, neurodegeneration and mood disorders worldwide. Dr Pizzorno – founding president of Bastyr University, co-author of Clinical Environmental Medicine and The Toxin Solution, and one of the world's leading voices in science-based natural medicine – draws on decades of research, clinical practice and large-scale human data to demonstrate that environmental toxins are now major drivers of neurological and psychiatric illness. He outlines how specific contaminants, including arsenic, pesticides, industrial chemicals, persistent organic pollutants (POPs), mercury and commonly used medications, damage the brain through mitochondrial dysfunction, oxidative stress, glutathione depletion, microglial activation and impaired apoptosis. In this deeply informative and practical session, Dr Pizzorno explains how clinicians and patients can meaningfully reduce toxic exposure and support detoxification through diet, lifestyle and environmental choices. By correcting nutritional deficiencies, decreasing total toxic load and improving the body's natural elimination pathways, he shows that biomarkers of oxidative and toxic burden can improve – and so can long-term brain health. In this episode, you will learn: Why the global epidemic of mental disorders aligns closely with rising exposure to neurotoxins and falling intake of protective nutrients. Which environmental toxins are strongly associated with dementia, cognitive decline, depression, ADHD, autism and Parkinson's disease. Why arsenic, particularly from contaminated water and food, is one of the most damaging neurotoxins linked to Alzheimer's disease, dementia and major cancers. How pesticides, PCBs and contaminated fish contribute to neurodegeneration and psychiatric symptoms. Why commonly used prescription and over-the-counter medications can act as neurotoxins and increase the risk of dementia. How toxins harm the brain through mitochondrial damage, oxidative stress and glutathione depletion. Why food is the single largest source of toxic exposure, followed by water, household chemicals, personal-care products and indoor air. Practical ways to reduce exposure at home, including air filtration, choosing cleaner products and improving food quality. How increasing dietary fibre and colourful plant foods supports toxin elimination and protects brain function. Why supporting glutathione and detoxification pathways – and maintaining these habits over time – can lower oxidative burden and improve long-term mental health.

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain's immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer's Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. You'll Learn: • How microglia shift between supportive and destructive states and why metabolism drives that change • How mitochondrial function inside immune cells influences inflammation and brain resilience • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain Resources: • Learn More About Dr. Perlmutter at: https://drperlmutter.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:45 - Autism Spectrum 4:38 - Alzheimer's & Beta Amyloid 7:02 - Brain Immune Cells 8:06 - GLP-1 & Parkinson's 10:44 - M1 vs M2 Microglia 13:08 - Pharmaceutical Microdosing 15:51 - Gene Therapy 19:09 - Mold & Toxins 21:58 - Environmental Pollution 26:05 - MPTP Discovery 29:07 - Healing Interventions 31:39 - Light & Sound Therapy 36:35 - Mitochondrial Function 44:57 - Inflammation & Prefrontal Cortex 48:00 - GLP-1 Global Impact 52:11 - Mitochondrial Community 56:05 - Consciousness & The Field 1:00:00 - Psychedelics 1:01:59 - Love & Judgment 1:06:35 - Death & Knowing 1:09:06 - Heart-Brain Connection 1:11:06 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Parkinson's disease is rising rapidly worldwide, and most cases are driven by lifestyle and environmental stressors rather than genetics, meaning daily choices play a powerful role in risk and progression The disease often begins years before diagnosis, with early signs like poor sleep, digestive issues, anxiety, and fatigue signaling stress on your brain long before tremors appear Chronic inflammation, toxin exposure, poor sleep, and metabolic strain weaken dopamine-producing neurons, but improving sleep, movement, diet, and stress regulation slow this damage Supporting gut health, reducing exposure to environmental toxins, and maintaining steady energy through proper nutrition help protect your brain and preserve mobility and cognition Consistent habits that lower stress, improve sleep quality, encourage movement, and support vitamin D balance give your brain the conditions it needs to stay resilient over time

Dr. Deb Muth 0:03Today’s guest is someone I’m honored to call both a friend and a mentor, and one of the most trusted voices in medicine for patients with complex chronic illness. Dr. Neal Nathan is a board certified family physician who has spent decades caring for patients who don’t fit neatly into diagnostic boxes. Patients with mold related illnesses, Lyme disease, mast cell activation, and profound nervous system dysregulation. These are the patients who are often told their labs are normal and their symptoms are anxiety or that nothing more can be done. Instead of dismissing them, Dr. Nathan listened and he asked better questions. His work, including his landmark book, Toxic, has helped thousands of people finally feel seen, believed, and understood, and more importantly, has given them a path forward when medicine failed them. This conversation is for anyone who reacts to supplements or medications, for anyone who has gotten worse instead of better with treatment, and for anyone who knows their body that something deeper is going on, even if they’ve been told otherwise. Dr. Nathan, I’m deeply grateful for your mentorship, your integrity, and the way you continue to advocate for the most vulnerable patients. I’m so glad to have you here today. And before we begin, grab a cup of coffee, tea, or whatever grounds you, because this is the conversation you’ll want to settle into. Now, before we go onto this conversation, we need to hear from our sponsors. So give us just a quick moment and then Dr. Nathan and I are going to dive in to his story and how this all started for him and leave you with some nuggets of wisdom that you can help yourself with. Ladies, it’s time to reignite your vitality. Primal Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that lasts. Get 25% off@primalqueen.com Serenity Health that’s PrimalQueen.com Serenity Health because every queen deserves to feel in her prime the right places and then we can get started. All right? So, Dr. Nathan, like I said, I’m so excited to have you here today. Tell us a little bit about how did you start your career? Because you didn’t intend to work with the most complex and sensitive patients, I’m sure when you started out. But what did you notice early on that made you realize medicine was missing something? Neil Nathan MD3:03You know, Deb, actually, I did start out wanting to work with the most complicated cases. My delusional fantasy when I started was I wanted to help every single person who walked into my office. And so when I left medical school, I realized pretty quickly that the tools that I learned there were not adequate to do That I needed to learn more. So I started on a passionate journey of discovery, if you will, in which I started studying with anyone who had anything interesting about healing to talk about. And I want to emphasize that I was interested in healing, not in what I’ll call medical technology. So medical school taught me to be a good medical technologist, but it didn’t teach me about healing. I graduated a long time ago. I graduated from Medical School in 1971. And the word holistic wasn’t even a word back in those days, but that’s what I was looking for over many, many years. I studied osteopathic manipulation, homeopathy, therapeutic touch, emotional release techniques, hypnosis. If it’s weird, I probably have studied it at some point. I wasted some weekends studying things that I don’t think were particularly valuable. And I’ve had some remarkable experiences with true healers that taught me how to expand my understanding of what healing really meant. So early on, when I first started practice, I would invite my colleagues to send me their most complicated patients because that was my learning. That makes me weird. I know that. I love some problem solving. You know, I’m the kind of person who I get up in the morning and I do all of the New York Times kinds of puzzles. That’s. That’s my brain wake up call. So actually I did invite my colleagues to send me their complicated patients, and they did. So, I mean, they were thrilled to have me in the community because these were people they didn’t know what to do with. And I was happy as a clam with all these complicated things that I had no idea what to do with. But it pushed me to keep learning more, to keep searching for this person’s answer. And this person’s answer, that constant question is, what am I missing? What is it that I don’t know or understand? What questions am I not asking this person that would help me to figure it out? So sorry for the long winded digression. Dr. Deb Muth 6:14No, I’m glad you shared that. I’m very similar to you. I didn’t seek out working with the most complex, but as I started that, I was always very curious as well. So I was the same as you. Every weekend I would learn something and hypnosis and naturopathic medicine, homeopathy, and all these quote unquote weird things, right? And there’s always a pearl that you learn from something. You never not learn anything, but some of it, you kind of take or leave or integrate or not. And, and I think it, it makes you a better Practitioner, because you have all these tools in your toolbox for helping people that nobody else has been able to help. And. And it’s just kind of fun learning. I mean, I’m kind of a geek that way too. I like to learn all those things. Neil Nathan MD7:00Learning is my passion. One of my greatest joys in life is going to a medical meeting and getting a pearl. Literally. I’m not one of these people at medical meetings that have a computer in front of me listening. And I have a pad of paper and I’m writing down ideas next to people that I’m working with. So that, oh, let’s bring this up for these people. Let’s bring this up for these people. So it’s like, oh, great. Can’t get right back to the office on Monday so I can start, have some new ideas about what I’m missing. Dr. Deb Muth 7:38Yeah, I do the same thing. I have my pad of paper and I do the same thing. And as I hear something, I’m thinking about a person that’s in my office that I haven’t been able to help, or we’ve been stuck on something, and I’m like, oh, there’s a new thing we can try. And it’s so exciting. I love that. Let me ask you this. Was there a time when you finally thought, like, if I don’t listen to these patients differently, they might not ever get better? Neil Nathan MD8:04That’s a very complicated question. The people that I was treating that weren’t getting better were the ones that got my greatest attention. And one of the questions that constantly troubled me still does is, is this person not getting better because of some feature of themselves, or is it because of something that I don’t know? So I’ve wrestled with that for a very long time. My answer to it now is, For a long time, I’ve been able to see what I will call the light in a person. Call it a healing spark and energy. It isn’t truly light. There’s just something about that person when I work with them where I know this person will get well if I stick with them long enough. And then when I don’t get that, I don’t think I’ve helped any of those people over the years. Yeah, so it was a very long process of really not helping people for five years daily. And I would. I would ask those patients, I would say, you know, I haven’t helped you. We’ve been doing this for a very long time. Why are you still here? And they would say, because you care. And I would. Back when I was Younger, that was enough for me to go. That’s true. Okay, I’ll keep working at it. But as I’ve gotten older, caring isn’t enough. It’s. I’m not sure I’m the right person for you. And so as I’ve gotten older, when I don’t see that spark, when I don’t get that sense of someone, I’m more inclined early on in the relationship to tell them I’m not the right person for you. Yeah, you know, see if you can find someone else who can understand what you’re going through and help you. Because I, I’m not it. Dr. Deb Muth 10:16Yeah, you, you kind of know that you can help them or not. Yeah. Neil Nathan MD10:21I don’t know how to define that sense, but it’s very clear to me. I call it like seeing the inner light of another being. If it’s not there, and maybe it’s not there for me to see as opposed to someone else can see it. Dr. Deb Muth 10:41That’s interesting. So you’re known for working with patients who are highly reactive. They don’t tolerate supplements, a lot of times medications, or even some of your most gentlest protocols. Why are these patients so often misunderstood? Neil Nathan MD 10:59Because they appear to their family and to many other physicians to be so sensitive that the thought process of families and other physicians is often. Nobody’s that sensitive. This has got to be in your head. And that is what is conveyed to those patients. And they’re told it’s gotta be in your head. Go see a psychiatrist or a therapist. But I can’t help you. And unfortunately, we have learned in the last 20 years a great deal about, is making our patients so sensitive. It is a true reaction of their nervous system and immune system, and it is in response to various medical conditions they have. So again, as we’ve been talking about, those were the people that got sent to me for many years. And I, I have never believed that the majority of any. Anything that someone has experienced is in their head. Yeah, Almost everything I look at is real. I may not understand what is causing it, but for me, doubting a patient’s experience is not something I’ve ever done. And that’s what’s helped fuel what I’ve learned and what you learned over the year. That, okay, if this is real, and it is, I’m sure it is, the person in front of me looks like a straight shooter. They’re not hyper reactive. They’re not going off the deep end talking about it and talking about it very straightforwardly. And I’ve got these symptoms. I’VE got this, I’ve got this. And it’s really making my life miserable. Okay, what’s causing that? So I began to work with what we now call very sensitive patients and figuring out what caused that. So over the years, I think we have names for this in medicine. Sometimes we call this multiple chemical sensitivity. People who will go to be walking down the street and someone will walk past them wearing a particular scent or perfume and they will literally fall to the ground or go brain dead or can’t think straight or even have some neurological symptoms. And I’ve seen that happen in my office. I’ve seen patients walking down the hall and having a staff member who had washed their clothes and tied walk past them. And I literally watched them fall on the floor. And it’s like, this is not psychological. This is someone who is reacting to the chemical that they are being exposed to and this is the effect it’s having on them. And so eventually it became clear that all forms of sensitivity, sensitivity to light, sound, chemicals, smells, food, EMFs, touch, were really being triggered by a limbic system that was unhappy. We began to learn about limbic issues before that. Give you a short history of it. I have discovered something called low dose immunotherapy different by Butch Schrader. And there was a long three year period of if someone stuck with it. If I used those materials over time, a lot of my chemically sensitive people would get better. It was the only tool I had back then. Dr. Deb Muth 14:41Yeah. Neil Nathan MD 14:42)Then, I don’t know, 15 years ago I discovered Annie Hopper’s work with dynamic neural retraining. And when I added that to what people were doing, that’s when I had my, ah, this is an Olympic system issue. And this is something we can reboot. And since then, many other people have limbic rebooting programs which are quite excellent and useful. Now I helped a lot of people at that point and it wasn’t until I stumbled on Stephen Porges work with the vagal system with this concept of polyvagal theory that I realized that the two areas of the brain that are monitoring that person’s environment, internal and external, for safety, are the limbic and the vagal systems combined. So when I started adding vagal strategies to the limbic strategies, I helped even more people. And then the first, the third piece of this trifecta was 2016 when Larry Afron wrote his book Don’t Never Bet Against Occam, in which he began our understanding of mast cell activation. And when I read his book, it was like, oh, big piece of the puzzle. And then we realized that those three things. And there’s more, but those three things were treated, Would help the vast majority of our sensitive patients regain their health and regain their equilibrium. This is not psychological. This is really treatable. Dr. Deb Muth 16:19Yeah, I’ve noticed the same thing in my practice and followed very similar paths. As you started out with ldi and lda, and then the vagus nerve things have been by far. I think if I look back, the vagus nerve work has been the biggest changer in our practice as well. I mean, all of the things help, but, like, I can give somebody a vagus nerve stimulator today, and within 30 days, 90% of their symptoms are better. And that just kind of blows my mind. It’s like I’ve never had a tool in my toolbox that has worked that well and that quickly. So. So it really is making a big difference. And I, too, was trained way back in the late 90s with multiple chemical sensitivity people. And some of those clients that I inherited from my mentor are still around. And, you know, they still can’t function at all. They’re wearing gas masks. They can’t leave their house. You know, any smells that even come in without them opening the windows, they are stuck. And no matter what you do, it’s just a challenge. Nothing works for them. And it’s a very sad life that they have to live. Neil Nathan MD 17:30Well, let’s add to that story that you can give people limbic vagal and mast cell treatments, and it’ll really work well to help them, but you need to look deeper, which is what is causing mass cell issues. And in my experience, mold toxicity is by far the number one and various components of lyme disease is a second one, and then a variety of other environmental toxins, infections, and things like that may trigger for some, but you’ve got to go back and get to the cause or else. Dr. Deb Muth 18:12Yeah, nothing works. Neil Nathan MD 18:13You can make them better, but you can’t really get them. Well, you get rid of the cause, and people can completely differently life back. Dr. Deb Muth (18:20-18:21)Yeah. Neil Nathan MD 18:22One of my frustrations with the mast cell world is after Larry efferent’s book came out, it changed people’s consciousness about mast cell activation. Something genetically rare to something which we now know. It affects 17% of the population, so not rare at all. But the clinics that are popping up to do it, and now in every major medical center of the country has a mast cell clinic. But number one, they rely completely on testing to make the diagnosis, and testing is notoriously inaccurate. And second, they just aren’t aware that you gotta get cause. So they’re helping people, but they’re not curing people because they’re not looking for cause. Dr. Deb Muth 19:13Yeah. And if they’re helping people, it’s on a minimal level, in my experience. They’re. You know, most of the patients that we see that have been at those clinics have been dismissed. Once again, told that because the testing isn’t positive and they’ve only done it once, that they don’t have this. But yet they fit all of the pictures. And then when you start digging, you start realizing they really do have mast cell, and. And you can find the answers for it for them. Neil Nathan MD 19:40Yeah. Dr. Deb Muth 19:41Why do you think mold remains so unrecognized in conventional medicine? Neil Nathan MD 19:48Interesting question. You know, I started writing a book chapter on the history of mold toxicity, our understanding of mold toxicity. And it’s. It’s fascinating to me. The mold toxicity is described in the Bible as a fairly long passage in Leviticus where it talks about that. So it’s not like it’s unknown to the universe, but largely, it’s remained undiscussed. Most people are aware of mold allergy. We’ve been treating mold allergy for decades. That we accept fully. I think the answer to your question lies in history a little bit. And I didn’t know this until I started kind of digging into it. There was an episode in the 70s in which a large number of school children in Cleveland, Ohio, got sick, and public health authorities attributed it to mold. About a year or two later, it was discovered that they. The H VAC system in the school had Legionella. Legionnaires disease. And it was then decided that, no, it wasn’t mold, it was legionnaires. And then a number of articles began appearing in the medical journals. Their names were literally mold. The hoax of mold toxicity. And that consciousness pervaded for 20, 30 years where people were reading these articles in which they were being told that mold toxicity was a hoax. That’s a strong word. And it took papers after papers after papers published in all kinds of medical journals, which were began to say, this is very real. This is symptoms that. That we see. It wasn’t until 2003, when Michael Gray and his team published a series of papers showing that these widespread symptoms, which we now recognize as mold toxicity, was real and directly attributed to mold. Now, keep in mind, we didn’t even have a test for mold at that point. Dr. Deb Muth 22:10Right. Neil Nathan MD 22:12So you could say this is mold toxin, because this person was. Well, they went into a moldy environment, they got sick, they went out of the moldy environment. They got well again, but we didn’t have treatments. We didn’t have a test for it. Historically, people were suspicious. Not very scientific. 2005, Richard Shoemaker wrote his book mole warriors, which really began to popularize the concept of this was a real thing. And in it, Ritchie talked about his markers and the visual contrast test. Now, these were not specific for mold, but they strongly, at least implicated that. Now, we had a test that could be helpful. So it wasn’t really until about 2010 that the first urine mycotoxin test came on the market. And at that point, we. We really could tell a person, you’ve got these symptoms, you’ve been living in mold. And now we have a test that shows you have mycotoxins in your urine. Now, it’s not like it’s a theory. It’s coming out of your body. That has furthered it, but not yet in the consciousness of the medical profession at large. As I’m sure you know, the history of medicine, in fact, the history of science, is that new ideas take 20 plus years to really be accepted by the profession. A new drug, a new technology is accepted very quickly because there’s an economic push to it. There’s no economic push to a new idea. So we’re still in the throes of some of us who work in the field. People say there’s no published data that really prove that this exists. And we’re working on that. As you know, we’re working on getting the papers published, but again, working on this history of molotoxism, There are actually hundreds and hundreds and hundreds of papers in the medical literature which really attest to the fact that this is a reality. It’s just that you and I are the only ones reading these papers. Dr. Deb Muth 24:33Yeah, we’re the only ones that care. Yeah. What would acknowledging mold actually forced medicine and the institutions to confront? Neil Nathan MD 24:44First of all, many medical offices and. Dr. Deb Muth 24:47Hospitals are molding, very much so. Neil Nathan MD 24:51And nobody wants to deal with that. It’s expensive. It’s difficult to truly get mold out of a building when it’s there. And so there’s a huge economic push to not acknowledge mold toxicity as an entity. The whole building industry doesn’t want to deal with it. Yes. It is estimated by the federal government that 47% of all molds have visible or smellable mold in them. It’s not like it’s rare. Not everyone’s going to get sick from it. But if your immune system takes a hit from anything and it loses containment over that mold, then you will take a hit from it. And it is also estimated that at least at this moment, 10 million Americans are suffering with some degree of mold toxicity and don’t even have a clue that that’s a real thing and that it can be both diagnosed and treated successfully. Dr. Deb Muth 25:51Yeah, it’s so hard. Like so many of the patients that we see, mold is never on their radar when they come to us. You know, Lyme disease is never on their radar when they come to us. And many of our patients have both. And the argument of there’s no way I could have, you know, mold exposure until you start digging back into their history a little bit. And then they’ll say, well, yeah, grandma’s house smelled and you know, I live in a hundred year old house, but it’s been completely renovated. And until you start having these conversations and really talking about it, people don’t have a clue that these things could make them sick. Or they, you know, I have a lot of clients that renovate houses for a living or that’s, you know, their hobby. And they go in and they renovate these houses and they’ve never worn appropriate equipment to protect themselves and, and then they’re sick 10, 15 years later. But don’t really understand why. Neil Nathan MD 26:47Yeah, from my perspective, it’s about how robust the immune system is. Dr. Deb Muth 26:51Yeah. Neil Nathan MD 26:52That if your immune system is robust, and this is true for Lyme as well as molecules, you could be bitten by a tick, you may have a Lyme or a co infection of Lyme like Bartonella rubesia in your body, or you could be exposed to mold, you could be living in a moldy environment, and your immune system will allow you to function at a high level for a while if your immune system takes a hit. Now the hit recently, big time, was Covid that unmasked Lyme and mold for a lot of people and a lot of people who think they have long whole Covid really have unmasked that they have Lyme and mold toxicity. That’s a whole other subject here. But menopause, childbirth, surgical procedure, any severe infection, any intense emotional reaction, death of a loved one, any of these can weaken the immune system. And then what is already there is no longer contained and we are off to the races of severely impaired health. Dr. Deb Muth 28:02Yeah, that’s what it did for me. I got sick with COVID and maybe about six, eight months later, I started to express neurological symptoms that looked like Ms. And actually had the diagnosis of Ms. But knowing what I know, I said, you know what? Ms. Is something else. Until proven otherwise in my book. And so because I had the knowledge that I did, I went and did all the Lyme testing and the mold testing and hit the trifecta of everything. Lyme co infections, mold, viruses. I just had everything. And as I started down that path of trying to clean it all up, all of my symptoms started to disappear. And certainly it wasn’t as easy as it sounds, and it wasn’t as quick. And I felt a lot worse before I felt better, as most of our clients do. But I think that I’m not the only person that this has happened to. And I think a lot of people get misdiagnosed just simply because nobody’s looking for the other problems that you and I look for and that we know of. And that’s one of the ways our medical system fails the clients they work with. Unfortunately. Neil Nathan MD 29:12One of the things that I teach and want people to be aware of is any specialist who makes the diagnosis that includes the word atypical. So atypical ms, atypical Parkinson’s, atypical Alzheimer’s, atypical rheumatoid arthritis, whatever it is, if that’s the word. What they’re saying is this has feedback features of this illness, but doesn’t really match what I see every day in my office. And when I hear the word atypical, I say, please look for mold, please look for Lyme. Because that is often the case here. Dr. Deb Muth 29:51Yeah, oftentimes it is. You also teach that when patients get worse under treatment, it doesn’t mean they’re failing. It means the treatment might not be appropriate for their psychology. Can you explain that a little bit? Neil Nathan MD 30:05Yeah. I think that many people start understanding about things like Lyme or mold and don’t really have the bigger picture. And so they will jump in with aggressive treatments in people who aren’t really ready for that degree of aggressive treatment. And here we’re going to come back to, if someone’s living vagal and mast cell systems are dysfunctional and not working properly, it is highly likely they won’t be able to take normal doses of the binders we use for mold, or to take antifungals or to take the antibiotics we need for Lyme disease. It’s not that they don’t want to. They can’t. And so what I see is not understanding what you need to do, in what order. If you do it in the right order, you’ll help the vast majority of people you’re working with. And again, that trifecta of limbic vaginal, mast Cell is one piece that a lot of people don’t address. And again, order matters. For example, in the mold world, some people have learned that, oh, I’ll need to give people antifungals to get this mold and Candida out of their body. But if you do that and you don’t have binders on board, there’s a very high risk that you’re going to cause a severe die off and make people really miserable. I remember when we kind of first started this, I was working with Joe Brewer, who’s an infectious disease specialist from Kansas City. And Joe wrote some of the earlier papers on this particular subject. And I was doing, I had a radio show at that point and Joe was on and we were talking about mold toxicity and how we treat it and what we did. And he mentioned that about 40% of his patients had this really nasty die off. And I went, I almost never see a die off. And so when we got off the program, we sat down and tried to compare notes about, okay, what am I doing differently than you, that I’m not getting the die off. And Joe, as an infectious disease specialist would go quickly to his antifungals. And yes, he put people on binders, but he also simultaneously put the lungs in pretty heavy doing antifungal. They got a nasty diure. I never put people in antifungals until their binders were up and running. So from my way of thinking about it, if you use any antifungal, they all work by punching holes in the cell wall of either a mold or a candida organism, killing it. However, by punching holes in it, what’s in that cell leaks out. And that includes mycotoxins. So. So you’re literally, if you’re using it aggressively, you can literally flood the body with mycotoxins. And if you don’t have the binders on board to mop it up, there’s a high risk that you’re gonna be pretty miserable. Cause you’re literally more toxic. Dr. Deb Muth 33:18Yeah, I remember in the early 2000s when they were teaching, if you’re not getting somebody to have that die off reaction, that quote unquote, herx reaction, then you’re not doing your job, you’re not giving them enough. And we would have clients that would come in and say, I’m not herxing. You’re not doing enough for me. And we were always the ones that are saying, you don’t have to hurt to get rid of this thing. I’m a naturopath too. And so preserving the adrenal Function was always very important to us. And we were like, if we cause you to hurts like that, now we’re depleting the adrenal system. We’re creating more problems that we’re gonna have to fix on the backside. And that was the narrative that was being taught back then. And I’m glad that’s not the narrative that’s being taught today, for sure. But people don’t understand. Like you said, you’re more toxic at this point, and creating more toxicity isn’t what we want to do. Neil Nathan MD 34:12It’s not good for healing. Kind of intuitively obvious, but you’re right. Back in the early days, we were taught that just to put a spin, I’ll call it on a nasty Herc’s reaction. Oh, great, we’re killing those little microbes. This is fabulous. Yep. I mean, that’s how we spun it back then. And currently I can’t say that some Lyme literate doctors still believe that, but most of us have realized that. No, that means we’re killing him too quickly. We need to modify what we’re doing so that we are killing it, but not at a rate that our patient is getting worse. Dr. Deb Muth 34:59Yeah, I always tell people we want to kill the bug, but we don’t want to make you feel like we’re killing you at the same time, because that’s what’s going to happen if we’re not careful. So, yeah, how does trauma and emotional or physical trauma and abuse and chronic illness, how do they all reinforce each other? Neil Nathan MD 35:24Our limbic systems have been trying to keep us safe since we were in our mother’s uterus. By again scrutinizing the stimuli we’re being exposed to from the perspective of safety. So none of us have had perfect childhoods. Yeah, some older than others. But depending on what you had in your childhood, maybe you had recurrent ear or throat infections and took lots of antibiotics. Or maybe you needed surgeries. Or maybe you had parents who were both working and not particularly available to you. Or maybe you had abusive parents in any way possible. But through your whole childhood experience, your limbic system is really going okay. This isn’t safe. This is not good for me. This is not right. And becoming more and more hyper vigilant to really be aware of that so it can try to keep us safe, which is okay. Maybe my parent was an alcoholic and okay, they’re coming in now. I’m going to make myself scarce. My limbic system is going to tell you, get out of here. Don’t put yourself in harm’s. Way, if that’s the case. And then as we go through our lives, more things occur. We have heartbreak when we’re teenagers, and we have difficulties with work or bosses or other things. Each insult of safety to us helps to create a limbic system that is more and more hypervigilant. So if you then have a trauma of any kind, it’s kind of like the straw that breaks the camel’s back at that point. And that could be mold toxicity, that could be Covid, that could be the loss of a loved one, that could be a betrayal of some point, any number of things, once that happens. Now that limbic system is super hypervigilant. Now, what that means is, symptomatically for people is we’re going to have symptoms in two main categories. Not to make us sick, but to warn us from our limbic system that, hey, this isn’t safe for you. You got to get into a safe place here. And those symptoms are in the category of emotion and sensitivity. So with any of our patients that we see, if they have become more and more anxious patients, panic, depressed, ocd, mood swings, depersonalization, derealization, that’s all limbic. And if they have any increase in sensitivity to light, sound, chemicals, smell, food, touch, EMFs, limbic. So most of our patients have gotten to that place. And as I’ve said, the vagal system comes along with the limbic system because it does the same job. Those symptoms are a little different. The vagal system controls the autonomic nervous system, and so things like temperature, dysregulation, pots, blood pressure, palpitations. The vagus nerve also controls almost all gastrointestinal function. So almost any symptom in the GI tract is going to have a vagal piece to it. Gas, bloating, distension, reflux, abdominal pain, constipation, diarrhea. So those are common symptoms in our patients. And it helps us to tease it apart that we can literally tell them these are symptoms of vagal dysfunction. These are symptoms of limbic dysfunction. And I hope I’m answering your question, which is, how does this evolve? It evolves throughout our whole life, and then eventually we get to the point where our limbic system is overwhelmed. And here’s the good news. We can treat this. We can fix it. We have various programs. And honestly, Deb, I believe that every man, woman and child on this planet needs limbic retraining, or at least limbic work. Co did a real number on the whole planet. Yeah, most people live in some degree of fear From a wide variety of causes. And we don’t have to live in fear. We don’t have to let us hurt us, but we do need to recognize that it is limbic, it is vagal, and we can do something about it. Dr. Deb Muth 39:58Yeah, that’s an exciting time for us, I think. You know, I. I agree. Like, the last couple of years have been very traumatic for a lot of people. Our young kids that were traumatized in school, their parents, the grandparents. I mean, everybody has gone through some kind of anxiety or fear around what’s happened in the last few years, and not to mention all the things that they’ve lived with their whole lives. And this just kind of came to a head and I think broke open for a lot of people that were suppressing their feelings up until this point. And it. It just was the perfect storm for a lot of people, unfortunately. And there’s a lot of people that can’t get over the trauma that’s occurred. The lying amongst the government and our families, how we treated each other and pushed each other aside and, you know, broken families apart because of their belief systems. It really did a number on people, and they’re really struggling to get back. Back for sure. Neil Nathan MD 40:56Yeah, we’re in complete agreement here. Dr. Deb Muth 40:59Yeah. Yeah. So many of our listeners, especially women, have been told their symptoms are anxiety or stress or quote, unquote, just hormonal. Right. And from your perspective, what damage does that kind of dismissal cause for people? Neil Nathan MD 41:16We have a fancy word for that, which is iatrogenic illness. Translation is your doctor is making you sick by treating you inappropriately, not making the right diagnosis and not honoring what you’re experiencing. There’s actually a new word that I’ve recently heard called medical gaslighting, in which you describe something to your doctor and he goes, no, this is in your head. There’s nothing really physically wrong with you, and you know that. No, no, no, no, no. I might be a little bit stressed by it, but something else is going on in my body. And they’re telling you, no, we tested you. Usually those testings involve doing a blood count and a chemistry profile, and that’s it. Those tests will not reveal the kinds of things we’re talking about because you’re not looking for the right thing. So it is really common for our patients to have been told that there’s nothing wrong with you. You need to see a psychiatrist because they don’t know enough to understand that the symptoms you’re describing, if you understood what you’re looking at, are very clear manifestations of Things. Things like mold toxicity and Lyme disease, chronic viral infections, a variety of other things. But your doctor has to know this in order to happen. And this is a failure of medical education. So if my message to everybody always is never doubt yourself or what you’re experiencing, it’s real, there’s never a reason to doubt that. If the people around you aren’t believing, you find someone who does. And again, to augment this, part of the problem is if families accompany the patient to the doctor’s office and they hear the doctor telling them it’s in their head, families become less supportive of their loved ones and go, well, doctor said, this is in your head. I don’t know why you feel so awful. And so families need the same point of view of trust your loved one’s perceptions. There’s no reason not to. Malaboring hypochondria is extremely rare. Gets talked about a lot. I’ve been practicing for over 50 years. I have rarely seen, seen anybody with those truly with those symptoms. So trust yourself. Good. Dr. Deb Muth 44:03I love that. What do you wish every clinician understood about listening? Neil Nathan MD 44:13I wish that every clinician had the same curiosity that we do, which is, I might not understand why this being in front of me has these symptoms or is ill, but I’m going to do everything in my power to figure it out. That means I’ll learn what I need to learn. I’ll study what I need to study to figure out why this person is sick. I really wish, and I understand kind of why that’s happened. My wife always thought that everyone was like me, which was Saturday mornings. My great joy in life was getting up early with a cup of coffee and reading medical journals or obscure medical books. That was my joy. She was shocked that most other people don’t. The way medicine actually evolved. We’re burning out doctors at a rate never before in the history of this planet by making them do things that are not in the service of patients, but are in the service of making money. And so doctors are being given seven minutes per visit. If you have a complicated person, there’s no way you could do income. Seven minutes. The way the system is set up, it doesn’t allow doctors to do their job. And then they’re under tremendous pressure to get the charts filled out properly, the way the advent of electronic medical records supposed to be. This great thing is it’s making doctors have to go home and spend two hours at home, not with their family, but getting their charts squared away. And I don’t think all patients realize the Kind of pressures that doctors are under. So to answer your question, I would like doctors to be more curious, but also, the system is broken, and I wish we could fix the system so that every patient could get the amount of time they needed with their doctor to really explore what’s going on and get to the heart of what’s happening. Dr. Deb Muth 46:31I so agree. So agree with all of that. If there was one question you would want every patient to ask their doctor, what would it be? Neil Nathan MD 46:44How would you treat me if I was your sister, mother, relative, whatever. Not what you want to do, theoretically. But if I were your wife, if I were your sister, how would you treat me? I don’t see that happening much, especially with elderly people. I see Doctors going, you’re 80. What do you expect me to do? I’m getting pretty close to being 80. And I expect you to help me because I want to function at this high level for a very long time. There was. It was an old joke that used to be Bella went in to see the doctor, and the doctor, he said, doc, my knee is all swollen and it’s tender and I’m having trouble walking on it. And the doctor said, you’re 102 years old. What do you expect? But, doctor, my other knee is perfectly fine, and it’s 102 years old also. So I once had the opportunity. I had a 100-year-old patient who had exactly that. So that was able to look at his knee and go, we’re going to take care of this. So it’s just older people need to be treated with respect, with the same thing, of absolutely no reason that they shouldn’t get the kind of attention that you would want your grandfather, your father, to have. Dr. Deb Muth 48:16Yeah, I love that question. So I have one last big question for you. If medicine were rebuilt around patients instead of systems, what would you change? First. Neil Nathan MD 48:33I would get rid of the middle man in medicine, the HMOs, the managed care organizations, where they take the profit and it’s being shunted into other areas. So rather than the physician being paid directly for what’s happening, they just get a piece of it that the managed care organization deems appropriate. You know, I grew up in what was called golden age of medicine back in the 70s, where I could do for people what they wanted done. People didn’t doubt that it was in their best interest and that if I ordered a test, it got done. I didn’t have to have someone else authorizing or tell me this is an okay or an appropriate test, I could do it. So I would go back to a. A practice of medicine, direct care, where you. Maybe there’s a system that would help reimburse you for it, but you could go to the doctor and you get what you need, and the doctor decides what you need. Actually, they’re the ones seeing you. Would a clerk in an office 600 miles away decide whether you can have this test or not? Have this test? Test? It doesn’t make any sense to me. I should be able to deliver what you want and need, and I should have the time it takes to really work with you. I’d like to go back to the 70s. Dr. Deb Muth 50:07Me too. Me too. Is there one thing that gives you hope right now for our system? Neil Nathan MD 50:16Honestly, I’m a very optimistic person. My answer is is no. I think the system is broken. I think it is being held intact by people who are profiting from this system. They have no interest in letting go of their profits for it, and they don’t have any interest in seeing that people get treated properly and well. So I think, as I said, the system’s broken. It needs to be rebuilt from the ground up. Dr. Deb Muth 50:45I agree. I agree. Dr. Nathan, thank you so much. Not just for the conversation, but for the way you’ve modeled curiosity and humility and compassion in medicine. It is an honor to work alongside of you, call you my friend, and learn from you. Thank you so much for that. For those listening, if this episode resonates with you, I want you to hear this clear clearly, your sensitivity is not a flaw. Your body is not broken. And needing a different approach does not mean you’re failing. Healing doesn’t happen by forcing the body. It happens when the body finally feels safe enough to heal. If this conversation has helped you and you feel seen, I encourage you to share it with someone who needs that as a reminder. Thank you for being here and thank you for sharing with us. Let’s talk wellness now. Neil Nathan MD 51:38So in this context, I just want people to be aware of one of my recent books, which is the Sensitive Patient’s Healing Guide, which talks about this in great detail. And the new second edition of my book, Toxic, goes over the whole mold Lyme thing in more detail. So again, that wasn’t intended to be self serving, but rather there are resources where you can learn even more about it than Deb and I are able to cover in this short interview. Dr. Deb Muth 52:09Yeah, absolutely. And your first book, Toxic, was amazing. So if people haven’t read it, you definitely want to read the second version of it because it is incredible. And Dr. Nathan, if there’s somebody that wants to get a hold of you. How do they find you? How do they learn more about what you’re doing? Neil Nathan MD 52:24A very complicated website. Neilnathanmd. Com. Dr. Deb Muth 52:30Perfect. Well, thank you for today. Neil Nathan MD 52:34You’re very welcome.The post Episode 253 – Environmental exposures, Lyme disease & multiple chemical sensitivities: integrative approaches to healing first appeared on Let's Talk Wellness Now.

Ambient documentation is becoming normal in clinics. But the most interesting “voice” capability may not be transcription at all.In the latest episode of Faces of Digital Health, Henry O'Connell (Canary Speech) explains why voice biomarkers stalled for decades: the field analyzed words, not the neurological signal behind speech production.Canary's approach focuses on the “primary data layer”—how the central nervous system drives respiration, vocal cord vibration, and articulation in real conversational speech. A few details that stood out: ⏱️ ~45 seconds of conversation can be enough for assessment

Dr. Margarita Fedorova outlines how genetic, environmental, and pathological factors interact in Parkinson's disease and what this means for patient counseling.  Show citation:  Blauwendraat C, Morris HR, Van Keuren-Jensen K, Noyce AJ, Singleton AB. The temporal order of genetic, environmental, and pathological risk factors in Parkinson's disease: paving the way to prevention. Lancet Neurol. 2025;24(11):969-975. doi:10.1016/S1474-4422(25)00271-6  Show transcript:  Dr. Margarita Federova: Welcome to Neurology Minute. My name is Margarita Fedorova, and I'm a neurology resident at the Cleveland Clinic. Today we're exploring a framework for understanding how genetic, environmental, and pathological factors interact in Parkinson's disease and what this means for how we counsel our patients. A personal view paper by Blauwendraat and colleagues, published in The Lancet Neurology in September 2025, addresses a critical question. We've identified over 100 genetic loci for Parkinson's, but how do they act? The common saying is genetics loads the gun and environment pulls the trigger, but this paper suggests the relationship may be more complex. The key tool here is alpha-synuclein seeding amplification assays or SAAs. These detect misfolded alpha-synuclein protein in cerebrospinal fluid. Over 90% of Parkinson's patients test positive for misfolded alpha-synuclein using this assay. But here's what's notable. 2% to 16% of neurologically healthy older adults also test positive with prevalence increasing with age. This means there are more asymptomatic people with detectable alpha-synuclein pathology than people with actual Parkinson's disease. Most of these asymptomatic individuals will never develop symptoms. This raises an important question. What determines who converts to a disease and who doesn't? By integrating SAA results with genetic data, researchers can examine whether genetic factors drive initial protein misfolding or whether they modulate the response to pathology triggered by environmental or random events. Preliminary data suggests polygenic risk scores don't strongly associate with SAA positivity in healthy older adults. In other words, people with high genetic risk for Parkinson's aren't necessarily more likely to have misfolded alpha-synuclein if they're healthy. This suggests most Parkinson's genetic risk factors may not be causing initial misfolding. Instead, they may be determining what happens afterward, such as whether the pathology progresses to clinical disease. LRRK2 mutations support this model. About 33% of LRRK2 related Parkinson's patients are SAA-negative compared to only 7% in sporadic disease. This means many people with LRRK2 mutations develop Parkinson's without the typical alpha-synuclein pathology. LRRK2 mutations also show varied pathology. Sometimes alpha-synuclein, sometimes tau, sometimes neither. This suggests LRRK2 may modulate responses to different initiating events rather than directly causing protein misfolding. What does this mean for us as clinicians? Asymptomatic SAA-positive individuals could represent a window for intervention. If we can understand what protects them from converting to disease or what triggers that conversion, we could enable earlier identification of at risk individuals and potentially intervene before symptoms develop. The authors call for large scale studies using SAAs in older populations, combined with genetic analysis and longitudinal follow-up. By integrating pathological biomarkers with genetic and environmental data, we can better understand the temporal sequence of events in development of Parkinson's. This approach could fundamentally change how we think about disease prevention and early intervention, potentially allowing us to identify at risk individuals before symptoms appear and develop targeted prevention strategies. That's your neurology minute for today. Keep exploring, and we'll see you next time. If you want to read more, please find the paper by Cornelis Blauwendraat et al titled The Temporal Order of Genetic, Environmental and Pathological Risk Factors in Parkinson's Disease: Paving the Way to Prevention, published online in September 2025 in Lancet Neurology.

What if you could detect early warning signs of serious health conditions in just minutes, from the comfort of your own home? Download Your Health Compass Assessment Tool: https://yourhealthcompass.org In this groundbreaking episode, longevity expert Lisa Tamati unveils the revolutionary Health Compass App - a privacy-focused wellness tool that empowers you to take control of your health destiny through evidence-based questionnaires and self-assessment. Forget expensive tests and lengthy doctor visits. This simple yet powerful app uses validated public health data to flag early indicators for conditions that matter most, putting the power of health awareness directly in your hands. In this episode, we explore: How the Health Compass App works: simple yes/no questionnaires based on symptoms and risk factors Early detection insights for Parkinson's, Diabetes, Alzheimer's, Cancer (Prostate & Breast), Multiple Sclerosis, Lupus, Asthma, Anxiety, and Depression Why privacy matters: non-personalised summaries that respect your data sovereignty The difference between empowering insights and medical diagnostics How this tool fits into your biohacking and peak performance toolkit Self-sovereign health: taking charge without compromising your privacy When and why to consult healthcare professionals based on your results The future of personalised health assessment technology Whether you're deep into biohacking, focused on peak performance, or simply want to stay ahead of potential health issues, this app becomes your companion for proactive, self-directed wellness. Lisa breaks down exactly how to use this tool effectively and why early awareness - not diagnosis - can be your most powerful health asset. Ready to take control of your health compass?

Gül Dölen is a pioneering neuroscientist in the emerging field of psychedelics. She's studied how psychedelics may assist in treating trauma, addiction, depression, and even Parkinson's. A key piece of her research has involved critical periods–when the brain is capable of rapid and deep learning. Psychedelics may be a master key for unlocking these critical periods and curing diseases of the brain. Dölen speaks with Krista Tippett, host of the “On Being” podcast, about what she's learning about the brain and its capacity to heal. Dölen is a professor at UC Berkeley where she teaches both psychology and neuroscience.

In this deep-dive episode, Dr. Jill Carnahan and Dr. O'Bryan explore why LPS is far more than a gut issue—and how it silently fuels systemic inflammation for decades before symptoms like Alzheimer's, dementia, Parkinson's, or autoimmune disease appear.

Roche/Genentech announced on June 15–16, 2025 that prasinezumab — an anti-α-synuclein monoclonal antibody — will enter Phase III trials for early Parkinson's disease after mixed but encouraging Phase II signals.  In this episode (watch on YouTube) we explain the biology behind α-synuclein targeting, summarize the PASADENA and PADOVA findings (what was missed and what looked promising), discuss safety issues and trial design challenges, and speak with experts/patients about realistic timelines and hopes for disease-modifying therapies To follow trials like this and to have customized information and results delivered to you directly, consider signing up to try Turnto and the AI sidekick Turny. Sign up here and use the promo code PDEDUCATION for a 10% discount: https://www.turnto.ai/sidekick?fpr=pdeducation Help to support this channel and out efforts to educate the world about Parkinson's Disease and get access to personalized content: https://www.youtube.com/channel/UC0g3abv8hkaqZbGD8y1dfYQ/join  https://www.patreon.com/pdeducation Please be sure to give support to our channel sponsors: Comfort Linen: https://comfortlinen.com/PARKINSONSDISEASEEDUCATION(15% off entire order when applying the code PARKINSONSDISEASEEDUCATION at checkout) Kizik Shoes: https://kizik.sjv.io/pdeducation Cure Hydration: https://lvnta.com/lv_XG06Rho8SSlXEq3qlV If you have products that you would like for me to review on the channel please send them here: Parkinson's Disease Education P.O. Box 1678 Broken Arrow, OK 74013 Medical Disclaimer All information, content, and material of this video is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider. Affiliate disclaimer: Keep in mind that links used for recommended products may earn me a commission when you make purchases. However, this does not impact what products I recommend. If I recommend a specific product it is because it has been vetted by myself or based on personal use. #parkinson #parkinsonsawareness #parkinsonsdisease #parkinsons #prasinezumab #monoclonalantibodies #alphasynuclein

Antti Vuolanto, CEO of Herantis Pharma, discusses the significant unmet need in Parkinson's disease and outlines Phase II plans for the company's lead asset HER-096.

Ashley Paul, MD joins us to learn more about diagnosing and treating tremors. She shares point to look for in a high‑yield history, physical exam findings, and how to think about medical management among much more.Please check out more of Dr. Paul's work here: “Parkinson's Foundation Fundamentals of Parkinson's Disease” CME video. Send us a textSupport the show Check out our website at www.theneurotransmitters.com to sign up for emails, classes, and quizzes! Would you like to be a guest or suggest a topic? Email us at contact@theneurotransmitters.com Follow our podcast channel on

Join “Conversations on Health Care” hosts Mark Masselli and Margaret Flinter to learn why Dr. Dorsey believes cleaning up our environment may be one of the most powerful public health tools we have right now. The post Is Parkinson's Preventable? Our Guest Says Yes appeared first on Healthy Communities Online.

In this episode of the Jack Westin MCAT Podcast, Mike and Molly continue their MCAT brain anatomy series by tackling one of the most underrated topics on the exam: how the brain actually makes you move.If you've ever thought “why are there so many brain parts just for movement?” this episode is your roadmap.You'll learn:

What if inflammation—not genetics, not aging, not bad luck—was the common thread behind most chronic disease?In this expansive and thought-provoking conversation, physicist, inventor, and engineer Samuel Shepherd shares his extraordinary personal journey after being diagnosed with a rare, terminal bone marrow cancer in 2003. Given no viable medical options, Sam turned to decades of scientific expertise to investigate inflammation, free radicals, and cellular breakdown—ultimately leading him to study astaxanthin, one of the most powerful antioxidants found in nature.We explore the science of oxidative stress, PD-L1 immune signaling, cellular transport, and why conventional antioxidant delivery often fails. Sam explains how he developed a patented glycosidic form of astaxanthin designed to improve absorption and target inflammation more effectively—and how this work reshaped not only his health, but his entire understanding of disease, aging, and resilience.This episode also dives into:Why inflammation may be the root driver of many chronic and neurodegenerative conditionsThe role of free radicals in cancer, Parkinson's, Alzheimer's, and metabolic diseaseHow modern diets—especially fructose exposure—impact inflammation over timeWhat HS-CRP can reveal about long-term health riskWhy curiosity, self-trust, and asking better questions matter more than blind complianceThis is not medical advice. It is an invitation into inquiry, responsibility, and deeper self-education—especially for those who sense that healing requires more than symptom management.If you're someone who values science, autonomy, and understanding your body rather than outsourcing it, this conversation will expand how you think about health, inflammation, and what's truly possible.Connect with Samuel: Website: https://valasta.net/ Youtube: https://www.youtube.com/@ValAsta Facebook: https://www.facebook.com/ValastaHome Connect with Kelly:⁠⁠⁠drkellykessler.com⁠⁠⁠Free Guide: Sacred Boundaries: ⁠⁠⁠http://drkellykessler.com/sacredboundaries⁠⁠Self-Respect Reset is a guided, body-based experience for women who struggle to set boundaries—not because they don't know what they need, but because it hasn't felt safe to honor it.Inside, you'll learn how to rebuild inner safety, strengthen self-trust, and create boundaries that actually protect your peace—without guilt, over-explaining, or self-abandonment.

Cuando los síntomas del Parkinson están bajo control durante el día, esto se conoce como estar en "on". Cuando los efectos del(los) medicamento(s) empiezan a desaparecer y los síntomas reaparecen o empeoran, se consideran periodos en "off". Estas fluctuaciones de los síntomas pueden variar de una persona a otra; algunas personas pueden notar más síntomas motores durante los períodos en "off", mientras que otras pueden verse más afectadas por síntomas no motores.     Los periodos en "off" pueden complicar las tareas diarias, sobre todo si suceden con mayor frecuencia a lo largo del día. En este episodio, hablamos con el Dr. Enrique Urrea Mendoza, neurólogo y especialista en trastornos del movimiento en Tallahassee Memorial Healthcare, para entender mejor por qué se producen los periodos en "off". Habla de los desencadenantes habituales que pueden contribuir a los periodos en "off" y comparte estrategias para manejar mejor estas fluctuaciones.   ¡Siga y califíquenos en su plataforma favorita de podcasts para recibir notificaciones cuando salga un nuevo episodio! Cuéntenos que otros temas le gustaría que cubriéramos visitando parkinson.org/podcastencuesta. 

No matter your age, whether you have Parkinson's or not, there are steps you can take today to boost your brain health. In this extended version of a popular Ask the MD video, movement disorder specialist, life medicine physician and MJFF Principal Medical Advisor Rachel Dolhun, MD, DipABLM, sits down with Ayesha Sherzai, MD, and Dean Sherzai, MD, PhD, known as The Brain Docs. Together they answer community questions and share tips for using lifestyle medicine to help your brain.Mentioned in this episode:The Foundation's landmark research study is exploring the connection between sense of smell and brain disease. People with and without Parkinson's can help by taking a free scratch-and-sniff test. Get yours at mysmelltest.org/request.

Former Professional Football Player & Miami Hurricanes alumni Bernie Kosar calls into the program to talk about his health battles, including early-stage dementia, Parkinson's, and over a hundred concussions. Kosar shares his journey through regenerative medicine, including a recent liver transplant, which has dramatically improved his cognitive and physical health. He also reflects on his NFL career and friends lost to similar struggles. Switching to the present, Kosar comments on the Miami Hurricanes' improved chances in the national championship, crediting strong offensive and defensive lines for their success. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ever feel busy all day long but still never have time for the things you actually want to do? In this episode, Anna uncovers why so many of us feel stuck maintaining our lives instead of improving them. She explains how everyday tasks like laundry, email, and tidying quietly expand to fill all available time, a pattern she calls "maintenance mode." You will learn how Parkinson's Law applies to real life, why busy feels productive even when it is not, and the four simple shifts that help you reclaim space for rest, growth, and joy without letting your life fall apart. Apply for a free time management coaching session: freetimecall.com. Full shownotes: abouttimepodcast.com/308.

In episode 228, Dr. Sina McCullough and Joel Salatin explore why conditions like Parkinson's, Alzheimer's, ADHD, cognitive decline, and other neurological disorders are rising simultaneously.Access the Entire Episode on Beyond Labels Premium HERE: https://beyondlabels.supportingcast.fm/Follow on InstagramFollow on XSubscribe on RumbleSubscribe on YouTubeFind Joel Here: www.polyfacefarms.comFind Sina Here: www.drsinamccullough.comDISCLAIMER

In this powerful episode of Light Body Radio, we explore what's possible when persistence meets emerging neuroscience. Diagnosed with stage three Parkinson's and facing early cognitive decline, today's guest refused to accept a predetermined outcome—and instead began a deep investigation into neuroprotection, brain cell health, and the body's innate capacity for recovery. This conversation unpacks the science behind neurological resilience, including glial cell support, glymphatic system function, and cutting-edge research that challenges the belief that neurodegeneration is always progressive. It's an inspiring and informative discussion for anyone navigating neurological conditions, brain health concerns, or seeking hope beyond conventional prognoses. © Light Body Radio-Podcast, 2026. All rights reserved. This podcast features background music by ScottHolmes Music. We have obtained the necessary licenses for the use of this music. Our license was renewed on May 7, 2024, and we have been using ScottHolmes Music since 2017. Unauthorized use or distribution of this podcast, including but not limited to the background music, is strictly prohibited and may result in legal action. For more information or to request permissions, please contact scott@scottholmesmusic.com.

Video: https://www.youtube.com/watch?v=A6ymQgVLC5cAutism & Parkinson's https://youtu.be/1E53ZYehUCU?si=69pKeFSKi07GGsATHypothyroid Biomarker https://youtu.be/X6CxX9kA6b0?si=Bkr8ZKooNdie-N6IDr. Kristen Lyall, ScD https://youtu.be/cjBR8m82KZQ?si=C-Tclr25oBbid7qGNicole Rincon & links to her other episodes in notes https://youtu.be/jRd7rE38W90?si=i8CvVutA4a1K9NzeDaylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autismChroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autismFig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autismCognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com00:00 Serotonin Recap: thalamocortical connections (esp. S1 somatosensory)02:41 Aromatic Amino Acids & UV-sensitive aromatic benzene rings04:56 Personal Sunlight Reversal Host reversed Hashimoto's (2005–2024) via increased sunlight07:58 Cell-Level Roles Serotonin drives neurogenesis, migration, dendrites/spines; T3 matures organelles, myelination & cellular energy11:00 Maternal Thyroid Dependency Fetus relies on maternal T3/T4 until ~weeks 16–20; hypothyroidism as easy, modifiable biomarker for autism/Parkinson's13:07 Substantia Nigra & Basal Ganglia Neuromelanin/dopamine loss in substantia nigra links autism & Parkinson's; disrupts basal ganglia go/no-go orchestration15:44 Mitochondria & Melanin Energy Cytochrome c oxidase produces H2O in ETC; melanin + water coupling provides power 18:00 Hypothyroidism Biomarker Call Undisputed, simple-to-check risk factor; urgent prenatal thyroid screening & sunlight exposure needed20:36 Modern Environment Impact Blue light/low sunlight blocks synthesis; upstream fixes (reflexes, thyroid checks, sunlight) offer prevention/recovery potential22:15 Serotonin & T3 Synergy Serotonin architects connections; T3 engineers cell/organelle maturity & myelination; combined deficits cascade into autism/Parkinson's24:00 Substantia Nigra Detail Loss of neuromelanin/dopamine in substantia nigra (mesencephalon) impairs basal ganglia; ties to movement disorders in both conditions25:44 Mitochondria Water Production Cytochrome c oxidase (complex IV) generates H2O; melanin & water 27:58 Final Synthesis & Implications Serotonin + T3 critical for cell development/myelination; maternal hypothyroidism disrupts both autism/Parkinson's riskX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Broadcast from KSQD, Santa Cruz on 1-15-2026: An emailer from Switzerland asks about fluorescein angiography requested before her first retina appointment. Dr. Dawn suspects protocol-based medicine screening for macular degeneration and suggests negotiating to see the doctor first given her different reason for seeing a retinal specialist. She encourages patients to maintain agency in medical settings. An emailer asks about creatine supplements. Dr. Dawn notes it helps muscle development in people doing weight training at 3-5 grams daily, but does nothing for aerobic-only exercisers. Claims about cognition and mood lack solid research. She advises against high-dose "loading," and cautions that creatine causes fluid retention problematic for congestive heart failure and should be avoided with stage 3 or higher kidney disease. Dr. Dawn reminds listeners it's not too late for flu shots, noting this season's H3N2 strain emerged after vaccine formulation was finalized. She laments mRNA vaccine research defunding, as that technology allows rapid reformulation. She describes organoids—tissues grown from stem cells that self-organize into primitive organ structures, enabling rapid drug screening without animal testing. Stanford researchers created assembloids by placing four neurological organoids together that spontaneously connected and built the ascending sensory pain pathway, offering new approaches to studying chronic pain. Dr. Dawn explains research showing satellite glial cells transfer healthy mitochondria to spinal sensory neurons through tunneling nanotubules. When this transfer fails, neurons fire erratically causing pain. Infusing healthy mitochondria into mouse spinal columns cured peripheral neuropathy—suggesting future periodic infusion treatments for humans. She reports Texas A&M researchers created "nanoflowers" from molybdenum disulfate that double stem cell's mitochondrial production, potentially supercharging regenerative medicine for conditions including Alzheimer's and muscular dystrophy. A caller asks about flu vaccines with egg allergy. Dr. Dawn explains that his gastrointestinal reactions to eggs differ from dangerous IgE allergies causing hives or anaphylaxis—GI intolerance doesn't preclude vaccination. Dr. Dawn reveals that 20 years of Parkinson's research followed a false lead. MRI showed increased iron in patients' brains, prompting iron chelation trials—which worsened symptoms. The problem: MRI detects paramagnetic ferric iron (stored, inert) not ferrous iron (biologically active). Patients accumulate useless ferric iron but are deficient in usable ferrous iron. Earlier 1980s studies showing that iron supplementation helped were ignored and abandoned prematurely. She suggests Parkinson's patients discuss iron supplementation with neurologists. She will post the link in the resources page on her website. A caller concerned about early Parkinson's describes tremors and balance problems in darkness. Dr. Dawn suggests darkness-related symptoms sound more like peripheral neuropathy than Parkinson's, recommending neurological examination and screening for diabetes, B vitamin deficiency, or heavy metal exposure. She confirms that sedentary lifestyle reduces mitochondrial production while progressive exercise builds both muscle and mitochondria.

Each year, around 90,000 people in the U.S. are diagnosed with Parkinson's, a neurodegenerative disease that can cause tremors and affect cognition. Scientists are working to identify some of the earliest signs of the disease, and to figure out how we might test for—and treat—Parkinson's in the future.Neurologists Emily Tamadonfar and Michael Okun join Host Flora Lichtman to discuss what we know about why Parkinson's starts and how it may be associated with genetic mutations, pollution, and other factors.Guests:Dr. Emily Tamadonfar is a clinical associate professor of neurology in the Keck School of Medicine of the University of Southern California in Los Angeles.Dr. Michael Okun is a professor and executive director of the Norman Fixel Institute for Neurological Diseases at University of Florida Health in Gainesville, Florida.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

It's time for our first Favored or Forsaken of 2026! Join Erin, Evan, and Jamie as we discuss Philip Yancey, plagiarizing sermons, and deer jerky ministry! You'll hear about relevant insights from Casting Crowns songs, we discuss whether or not a sermon is even important to the Sunday gathering, and we present super specific ministries we would like to bring into the world. MENTIONS​Philip Yancey: Here's the Christianity Today article | Parkinson's Article Research Corner: Why More Marriages End When Wives Become IllIs sermon plagiarization ok? Here's the article | Stealing Sundays on YouTubeDeer Jerky Ministry: Here's the article | Boone Brothers Book Recommendation: The Serviceberry by Robin Wall KimmererThe Faith Adjacent Seminary: Support us on Patreon. I've Got Questions by Erin Moon: Order Here | Guided Journal Subscribe to our Newsletter: The Dish from Faith AdjacentFaith Adjacent Merch: Shop HereShop our Amazon Link: amazon.com/shop/faithadjacentFollow Faith Adjacent on Socials: Instagram See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.