Podcasts about intracellular

Rabbi Richard Louis Price, M.D. is a Yale & Columbia University-trained psychiatry professor at Weill Cornell Medical College/New York-Presbyterian Hospital. Over the past two decades, he has evaluated over 20,000 patients serving as a medical director at Achieve Behavioral Health in Monsey; Rockland TMS & Wellness Center; Hamaspik of Orange and Rockland Counties; Volunteer Counseling Services in New City; ParCare in Brooklyn, Chai Urgent Care Centers of New York, Pennsylvania, and Florida,, and has a private pediatric and adult psychotherapy and psychopharmacology practice in Monsey, New York. Dr. Price is triple board certified in Psychiatry, Consultation-Liaison/Mind-Body Medicine, and Addiction Medicine and has been awarded numerous patents in the United States, Canada, Europe, and Israel for a novel pharmacotherapy for the treatment of both core and associated symptoms of Autism Spectrum Disorder. Dr. Price has served on the advisory boards and as a national speaker for several pharmaceutical companies, such as Abbvie, Alkermes, Allergan, Almatica, Axsome, Idorsia, Intracellular, Janssen, Jazz, Lumbeck, Neuronetics, Otsuka, Supernus, and Vanda and has been recognized as a top Medical Educator by the American Psychiatric Association. He is also a professional singer and taekwondo black belt.     ADHD ARTICLE PUBLISHED: https://pmc.ncbi.nlm.nih.gov/articles/PMC10374479/ HISTORICAL OVERVIEW OF VILOXAZINE: https://pmc.ncbi.nlm.nih.gov/articles/PMC8219567/  

"Every year after my birthday, I noticed I got stronger. This protocol allowed me to set a world record in chest press at the age of 63." - John Jubilee John and Chelsea Jubilee are the co-founders of Energized Health, a pioneering health company dedicated to cellular health and wellness. With over 20 years of experience in operating businesses, John and Chelsea have become visionaries in the health industry. John holds a deep understanding of intracellular hydration and health optimization at the cellular level, while Chelsea brings expertise in the healing of cellular trauma. Their combined efforts focus on transforming the mind, body, and spirit, ensuring holistic health improvements for their clients. Episode Summary: In this enlightening episode of "Oh, My Health... There Is Hope," host Jana Short welcomes John and Chelsea Jubilee, the innovative minds behind Energized Health. With a mission to optimize health at a cellular level, John and Chelsea share their personal journey, insights, and groundbreaking methodologies that promise to transform health and wellness. John Jubilee recounts his personal struggles with health issues and the subsequent research that led him to develop the concept of intracellular hydration. Chelsea adds depth to their mission by discussing the significant role of cellular trauma and its impact on overall health. The couple elaborated on how their combined sciences not only rejuvenate the body at a cellular level but also offer incredible health benefits such as increased energy, reduced brain fog, and enhanced mental acuity. They further detail how their 88-day protocol promotes sustainable wellness, eliminates the need for ongoing treatments, and offers a holistic approach to health, mind, and spirit. Key Takeaways: Intracellular Hydration: This concept focuses on hydrating cells from within, providing substantial health benefits and reversing various medical conditions. Holistic Health Approach: John and Chelsea's protocol caters to the mind, body, and spirit—ensuring overall wellness. Reversing Illnesses: The protocol has shown promising results in reversing chronic conditions such as diabetes, high blood pressure, and even joint issues. Community Support: Energized Health offers a supportive community and experienced coaches, including former nurses who have transitioned from traditional healthcare to this innovative approach. Youthful Longevity: Emphasizing the importance of starting early, the protocol benefits people of all ages, and ensures long-term health and vitality. Get in touch with Chelsea: www.energizedhealth.com Get in touch with Jana and listen to more Podcasts: https://www.janashort.com/ Show Music ‘Hold On' by Amy Gerhartz: https://www.amygerhartz.com/music. Get the Best Holistic Life Magazine Subscription! One of the fastest-growing independent magazines centered around holistic living. https://bestholisticlife.info/Subscription Grab your gift today: https://www.janashort.com/becoming-the-next-influencers-download-offer/ Connect with Jana Short: https://www.janashort.com/contact/

Dr. Cate Shanahan, “The Energy Doctor,” is a Cornell-trained physician-scientist whose works have inspired entire movements involving bone broth, live-culture ferments, and seed oil-free business empires. Together, with NBA legend Gary Vitti, she created the LA Lakers PRO Nutrition program, which has been emulated by elite championship teams around the world. Dr. Cate is back for a threepeat to discuss her new book Dark Calories, in which she introduces you to well-respected scientists who warn that vegetable oils are a public health disaster, wreaking havoc on your body's cells by depleting antioxidants and promoting free radical toxicity. Their many effects include: Uncontrollable hunger, resulting in the need for drugs to maintain your weight Inflammatory fat buildup under your skin and within your internal organs and arteries Blood sugar swings that promote bad moods and antisocial behavior Disrupted brain energy, concentration problems, and mental illnesses Intracellular oxidative stress that promotes cancer development Gut inflammation, bloating, heartburn, and "the runs" Important protein powder note: During our discussion, Dr. Cate and I expose the issues with the oxidation and processing of protein powders. Oxidation can indeed be an issue for all food and supplement products. This is why, at my supplements company Kion, we negotiate higher up the supply chain to get fresher raw ingredients, have negotiated rights to reject products based on oxidation and use an ISO-certified fulfillment center specialized and certified for food warehousing and fulfillment. For Full Shownotes here: https://bengreenfieldlife.com/darkcalories Episode Sponsors: Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/BEN and using code BEN at checkout. BioStack Labs: Get 15% off your purchase of $100 or more by going to biostack.com/ben15. Magic Spoon: Scoop up these new, crispy, crunchy, protein-packed treats at your nearest grocery store or visit MagicSpoon.com/greenfield to save $5 on your order today! BEAM Minerals: Go to beamminerals.com and use code BEN at checkout for 20% off your order. Aires Tech: Aires Tech is offering you a 30% discount at airestech.com/ben—just use code BEN30.See omnystudio.com/listener for privacy information.

Thomas Levy, MD, JD,  is a board-certified cardiologist and a bar-certified attorney. After practicing adult cardiology for 15 years, he began to research the enormous toxicity associated with much dental work, as well as the pronounced ability of properly-administered vitamin C to neutralize this toxicity. He has now written 13 books, with several addressing the wide-ranging properties of vitamin C in neutralizing all toxins and resolving most infections, as well as its vital role in the effective treatment of heart disease and cancer. Others address the important roles of dental toxicity and nutrition in disease and health. Inducted into the Orthomolecular Medicine Hall of Fame in 2016, Dr. Levy continues to research the effect of the orthomolecular application of vitamin C and antioxidants in general on chronic degenerative diseases, including heart disease. His ongoing research involves documenting that all diseases are different forms and degrees of focal scurvy, arising from increased oxidative stress, especially intracellularly, and that they all benefit from bio-oxidative therapy protocols that optimize the antioxidant levels in the body while eliminating pathogens. In particular, the cause-and-effect relationship between oral cavity infections and all heart attacks is now solidly established.

Overcoming Confusion and Misinformation in Meeting the Needs of Children on the Spectrum While I'm used to guiding health-minded audiences deep down the Rabbit-Hole of water topics, today's discussion with Karen will be light on science and heavy on practicality. It aims to explain the challenging path for families who are intent on providing the safest and healthiest water for children on the Autism Spectrum and other Special Needs. Choosing water for consumption (drinking, beverages and food preparation) and water for bathing water for your family is daunting task because of the minefield of misinformation and hype that is associated with suppliers of water treatment for consumers. You cannot trust the Internet, your local water dealer, big-box stores or persuasive TV promotions. It is unconscionable and embarrassing to me – someone who spent the past 50+ years in the water industry that it has has not kept up with the current state of water contaminants AND the growing assaults on the declining state of health of humanity. Based on decades of observing homeowner's selection of water treatment technology, I conclude that more than 80-90% purchase and install inadequate systems for their and their children's health needs. Introduction The human body is 50% to over 90% water by weight depending on the stage of life. Not too long ago it was revealed that if we were to segregate all the types of molecules that make up the body, H2O would amount to 99% of them! An adult body contains roughly 40 liters of functional water derived from more than a billion years of evolution in the sea. No other single factor had such a profound influence on the animal kingdom's biological design and function. There are two primary compartments in the body: The Extracellular fluid (ECF) and the Intracellular Fluid. So, our 50+ trillion cells are floating in the Extracellular fluid (the Terrain) and contained within them is the Intracellular fluid where all the action is. It is the biochemical quality of the Terrain that governs overall health. Virtually all the great physiologists over the past 2 centuries agree one central concept – “The Terrain Is Everything” Understanding healthy hydration and how to maintain it Maintaining proper hydration is not only about consuming enough water. In fact, consuming an excessive amount of water can interfere with optimal hydration. Many factors can jeopardize the body's ability to maintain healthy hydration (illness, diarrhea, excessive work or exercise in hot climates, an imbalance in the quantity and variety of electrolytes). Key indicators of dehydration are varied and can include Lightheadedness or dizzy feeling Dry mouth and tongue and cracked lips Less frequent need to urinate Muscle cramps Thirst Frequent headaches Fatigue or drowsiness Urine has a darker color Eyes more sunken than usual The key physiological measure in achieving proper hydration is having sufficient water inside our cells – referred to as intracellular water. Sufficient pure water with the proper quantity and mix of electrolytes is key to achieving optimal hydration. A very rough daily guideline for those in good health is to consume – as water or sugar-free beverages (e.g. coffee, tea, vegetable juices, etc.)... Click Here or Click the link below for more details! https://naturallyrecoveringautism.com/199

Jonathan Weitzman, professor of genetics at the Université Paris Cité in France, joins Jonathan Sackier to discuss the role of epigenetic events in cellular differentiation programmes, as well as his own podcast, ‘The Lonely Pipette'. Use the following timestamps to navigate this episode: (00:00)-Introduction (02:49)-Specialising in epigenetics (05:45)-Helping young scientists navigate their careers (11:58)-Back to basics: epigenetics (19:21)-The emergence of ‘form' (22:02)-Cell reprogramming (23:26)-The Centre for Epigenetics and Cell Fate (24:28)-Genetics in 30 seconds (29:30)-Intracellular hijackers (35:45)-Who am I? (41:20)-Jonathan's three wishes 

In this episode, we delve into intracellular NAD+ testing and explore self-experimentation aimed at optimizing NAD+ synthesis. From supporting the salvage pathway, de novo synthesis, and the Preiss-Handler pathway to inhibiting the CD38 enzyme, we will uncover some key nutrients and precursors that will enhance NAD+ stores and production. Topics: 1. Importance of NAD+ - Cellular processes involving NAD+ - NAD+ as a coenzyme for numerous enzymes - Focus on energy metabolism 2. Energy Metabolism and NAD+ - Glycolysis and NAD+ - Krebs cycle and NAD+ - Electron transport chain and ATP production 3. Disruption of NAD+ to NADH Ratio - Inhibition of electron transport chain - Role of reactive oxygen species (ROS) 4. Strategies to Restore NAD+ Levels - De novo synthesis pathway of NAD+ - Preiss-Handler Pathway - Salvage pathway - Supporting pathways with supplements - CD38 Enzyme inhibition: how and why? 5. Personal Experimentation and Results Sharing - Self-experimentation to optimize intracellular NAD+ - Reporting results of experimentation Thank you to our episode sponsor: ⁠Dr. Morse's Daily Detox Kit⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Welcome to the Gladden Longevity podcast, and in this episode, Dr. Gladden speaks with Jeff Lioon. Jeff, born into the health industry with family ties to Douglas Laboratories, initially pursued a corporate career. After finding himself unfulfilled, he embarked on a transformative journey, including working with Ayahuasca in the Amazon. Dissatisfied with the corporate world's impact on his well-being, he left his job, explored carnivore diets, and mastered animal processing in Hawaii. Realizing his true calling in health, he returned to Austin to join his father in promoting Oligoscan technology for understanding mineral deficiency root causes. Jeff's journey reflects a shift from corporate life to holistic health pursuit. In this episode, Jeff, born into the health industry, shared his journey from corporate burnout to holistic wellness. Inspired by Ayahuasca's experiences, he left his NYC job and spent a transformative year exploring, then immersed in carnivore living. Realizing his true purpose, he joined his father in promoting Oligoscan technology. His story highlights a quest for holistic health, emphasizing the impact of lifestyle choices, nutrition, and spiritual well-being. The episodes promote sweating for detox, avoiding processed foods, and recognizing the spiritual dimension in overall health. Tune in as they discuss detoxification pathways, the benefits of sauna usage, the importance of a nutrient-rich diet, and so much more. So grab your headphones and get ready to embark on an enriching and insightful journey with the Gladden Longevity podcast.     Dr. Gladden says the conversation with Jeff was a fascinating one.  (00:55) In quantum thinking, all things are possible. (3:26) Dr. Gladden asked Jeff to share how he got into the health space. (5:22) Jeff shares that he wanted to see how the world works. (7:18) Dr. Gladden reveals how he went to Case Western, among other options. (9:45) Steve asks Jeff what biomagnetism is all about. (11:44) Dr Gladden asked Jeff to talk about oligoscan. (14:30) When people go on crash diets, they get toxic and feel pretty terrible because they are releasing toxins into the bloodstream. (16:57) Jeff recollects the first time he scanned himself using a technology his dad brought home. (19:10) Dr. Gladden mentions using oligoscan at a Radfest meeting earlier. (22:17) Jeff gives an example of a patient with high antimony due to drinking from plastic regularly. (24:30) Jeff believes the sauna is great and one of the excellent healing modalities. (27:51) Dr. Gladden asks Jeff about the number of elements they are currently testing. (30:40) Jeff notes that right now, most people have a magnesium deficiency. (34:10) Antiperspirant blocks the lymphatic system. (37:25) The body loves variety and nutrient density. (42:34) Jeff answers the question about what we will do differently in two to five from now. (45:56) Some toxins can get stuck into the structure of the body. (45:31) Dr. Gladden shares about Heliocare. (51:30)   To know more about Jeff: Website: www.TheOligoscan.com Instagram: @JeffLioon / @TheIntracellularPodcast Website: aynimana.com     Affiliate Link/Code:  https://www.zeolitelabs.com/?ref=oligoscan     Coupon Code: OLIGOSCAN10   Use the code ‘podcast10' to get 10% off your supplements at the Gladden Longevity Store.

In this episode, we review the high-yield topic of⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Intracellular Organisms⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

The question I keep asking myself is why is it we always hear about that some people can't or don't get positive results with a Ketogenic diet (aka Low Carb High Fat). Whether it is the Virta Health study or any one of various Obesity and Lifestyle Clinics around the country. It is pretty much common knowledge that about 50 % will get positive results, which usually mean weight loss or reversing diabetes. However that also means that 50% of those attempting the LCHF diet did not find any positive benefit for their efforts. WHY IS THAT THE CASE?This discussion is about exactly that. Going over some our collective (anonymous) results to reveal some of their common lab markers, metabolic problems that may have been an Invisible Obstacle for these people. It was only by looking deeper into areas that hadn't been examined before, a Metabolic lab panel, Hormone panel, Intracellular nutrient panel, and Genome analysis, that we found problems that they didn't know they had which could be easily improved and then make the Ketogenic easy to implement.—————————COME SAY HI!!! —————————— Facebook Group about Keto: https://www.facebook.com/groups/ketonaturopath/ BLOG: https://ketonaturopath.com/ Pinterest: https://www.pinterest.com/ketonaturopath YYouTube channel www.youtube.com/ketonaturopath Podcast: https://www.buzzsprout.com/482971/episodes Our Youtube Podcasts https://studio.youtube.com/channel/UC6LBX8_RDaXtzF_Z02jvl0QJudi's NEW cooking channel Keto Naturopath Kitchen https://www.youtube.com/c/KetoNaturopathKitchen       ——————————— OUR COURSE —————————— PSMF 30 day course: https://www.thebiointegrationcode.com/courses/PSMFChallenge————WHERE WE GET OUR GENOME SNP ANALYSIS DONE—————Strategene https://bit.ly/3iqCfka ——————————WHERE WE GET YOUR LABS DONE—————https://www.UltaLabTests.com/ketonaturopath ————————— WHERE WE BUY OUR SUPPLEMENTS ——————https://us.fullscript.com/welcome/drgoldkamp/signupWhy get a Fullscript account to get your supplements?? 1. They have more brands than anywhere else to choose from; 2. Their prices are 20 -50% lower than anywhere else; compare and you'll see 3. This is where most physicians have their account 4. Been in existence for nearly 30 years working with physicians and health practitioners sustained outcomes in the end.

Guest: Jeff Lioon Jeff Lioon is the Creative Director of Oligoscan. Being the son of the Founder of Douglas Labs, he's been immersed in both the nutritional supplement and health industry practically his entire life. He's spent the past 7 years studying and interpreting Oligoscan Test Reports and understanding the complex relationships between Heavy Metals and Minerals. Jeff is also an avid hunter and teaches individuals how to hunt and process animals in the Hill Country of Texas.  Instagram: @jefflioon Websites: www.theoligoscan.com www.aynimana.com   Work With Me: My Instagram: @integrativematt My Website: Integrativethoughts.com   Advertisements:   Valence Nutraceuticals: Use code ITP20 for 20% off https://valencenutraceuticals.myshopify.com/   Zeolite Labs Zeocharge: Use Code ITP for 10% off https://www.zeolitelabs.com/product-page/zeocharge?ref=ITP Magnesium Breakthrough: Use Code integrativethoughts10 for 10% OFF https://bioptimizers.com/shop/products/magnesium-breakthrough Just Thrive: Use Code ITP15 for 15% off https://justthrivehealth.com/discount/ITP15 Therasage: Use Code Coffman10 for 10% off https://www.therasage.com/discount/COFFMAN10?rfsn=6763480.4aed7f&utm_source=refersion&utm_medium=affiliate&utm_campaign=6763480.4aed7f   Chapters: 00:00 Introduction and Background 02:30 The Impact of Family Background 06:01 The Effects of Corporate Takeovers in the Supplement Industry 10:13 The Importance of Quality in Supplements 13:39 Personal Journey and Awakening 15:50 Transition to Health Industry 24:38 Exploring the OligoScan 31:28 Understanding the OligoScan Technology 38:17 Mercury Toxicity and Detoxification 45:03 The Importance of Knowing Your Blood Type 46:18 Instant Results and Convenience of the Scan 47:29 Jeff's Personal Experience and Journey 50:30 The Need for a Holistic Approach to Health 53:40 Reducing Toxic Load: Water and Air 58:59 Different Approaches to Diet and Nutrition 01:02:26 Common Patterns and Findings in Test Results 01:11:32 The Impact of Aluminum and Iron on Health 01:17:04 The Importance of Balance and Detoxification 01:17:56 Understanding Sulfur and Zinc Levels 01:19:03 The Impact of Diet on Mineral Levels 01:21:00 The Importance of Sulfur in the Diet 01:23:16 The Connection Between Plastics and Weight Gain 01:25:41 The Role of Copper Toxicity in Vegetarian and Vegan Diets 01:26:18 The Relationship Between Copper and Zinc 01:29:09 The Importance of Zinc in the Diet 01:30:32 Recommended Foods and Supplements for Mineral Balance 01:35:35 The Benefits of Zeolite as a Binder 01:36:43 The Potential of Homeopathy in Mineral Balancing 01:41:38 The Use of Turpentine and Sugar for Parasite Cleansing 01:43:12 Finding an OligoScan Practitioner 01:45:25 The Importance of Sodium-Potassium Ratio 01:50:28 The Complexity of Mineral Balance and Retracing 01:54:55 The Role of Interpretation in Mineral Testing 01:55:14 The Personal Impact of Hunting 01:57:08 Hunting and Processing Game 01:59:31 Trips and Contact Information 02:00:22 Interest in Hunting 02:01:46 Shipping and Resources 02:02:23 Finding Jeff Lioon   Summary: The conversation covers topics such as the impact of family background on health, the effects of corporate takeovers in the supplement industry, the importance of quality in supplements, personal journey and awakening, transition to the health industry, and understanding the OligoScan technology. In this part of the conversation, Matthew and Jeff discuss the impact of mercury toxicity and the challenges of detoxification. They also explore the importance of knowing one's blood type and the convenience of instant results from the scan. Jeff shares his personal health journey and the need for a holistic approach to health. They discuss the significance of reducing toxic load through water and air filtration. The conversation also touches on different dietary approaches and common patterns found in test results. The chapter concludes with a discussion on the impact of aluminum and iron on health and the importance of balance in detoxification. This part of the conversation explores the importance of sulfur and zinc levels in the body, the impact of diet on mineral levels, and the connection between plastics and weight gain. It also discusses the role of copper toxicity in vegetarian and vegan diets, the relationship between copper and zinc, and recommended foods and supplements for mineral balance. The benefits of zeolite as a binder and the potential of homeopathy in mineral balancing are explored. The conversation also touches on the use of turpentine and sugar for parasite cleansing, finding an OligoScan practitioner, and the complexity of mineral balance and retracing. Lastly, the personal impact of hunting is discussed. In this conversation, Jeff Lioon discusses his passion for hunting and processing game. He shares his methods for skinning, tanning hides, and making skull mounts. Jeff emphasizes the fulfillment and gratitude that comes from hunting and processing one's own meat. He also mentions his hunting trips in Austin, Texas, and provides contact information for those interested in joining him. The conversation concludes with a discussion on shipping game meat and resources for learning about hunting.

Water seems like a simple topic, right?  Not so fast!  There is quite a lot to know about the water we drink and the water we use in our daily lives.Water is a key component of life.  Every living organism must have water to survive.  Today we jump into the deep end of water with Jess Higgins Kelley, a Master Nutrition Therapist and Oncology Nutrition Consultant.  Jess truly takes a deep dive into water and the importance of hydration for our overall health. Jess has something for everyone today!  You won't want to miss all the nuggets of information about water including: water as the master nutrient,hydration for various health conditions,the importance of water quality,electrolytes and why they matter, and so much more!Connect with Jess Kelley at the Oncology Nutrition Institute:https://www.oncologynutritioninstitute.com/Suggested Resource Links:BOOK:  The Metabolic Approach to CancerMercola/Bush Hydration PodcastLMNT ElectrolytesTrace Minerals ElectrolytesEnvironmental Working Group (EWG)LINK:  Home urinalysis stripsLINK:  Home urine sample collection cupsNote from Jess:  Carbonated vs Non-Carbonated Water and Hydration Status. There are currently no studies showing both intracellular and extracellular hydration status when comparing carbonated vs non carbonated water. Intracellular hydration is more important to mitochondrial function than external. Because of this, currently it is widely accepted that both are equally hydrating. However, since we practice ancestral nutrition, we know that humans didn't add carbonation = carbonic acid a weak acid, to water until about 100 years ago. It also REALLY depends on the sparkling water/carbonated water source. In general, plain mineral waters in glass are excellent. Those with any artificial or natural flavors, sugars, etc should be avoided. All that said, many people do not have access to drinking water AT ALL so something is better than nothing!!!!

This is a big deal - tonight we discuss the second 10+ reasons and benefits of getting intracellular micronutrient testing. Can you reverse diabetes, relieve neuropathy, grow thicker hair, and balance hormones form proper supplementation? Remember, tonight we pick the winner of the FREE CMA with the stipulation that we have to record the visit with you to help others understand the process of intracellular testing. You in? Order your own test today and start feeling AMAZING at danpursermd.com

In this CME episode, Dr. Andrew Cutler interviews Dr. Vladimir Maletic about the impact of residual symptoms on patients with major depressive disorder, as well as treatment modifications to address residual symptoms in these individuals. Optional CME/CE Credits and Certificate Instructions: After listening to the podcast, to take the optional posttest and receive CME/CE credit, click: https://nei.global/POD23-MDD Learning Objectives: After completing this educational activity, you should be better able to: Describe the burden of residual symptoms in patients with major depressive disorder (MDD) Implement measurement-based care to assess residual MDD symptoms Modify treatment strategies to address residual MDD symptoms, including cognitive impairment, anhedonia, emotional blunting, and sexual dysfunction Accreditation: In support of improving patient care, Neuroscience Education Institute (NEI) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. NEI designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. A posttest score of 70% or higher is required to receive CME/CE credit. The content in this activity pertains to pharmacology and is worth 1.0 continuing education hour of pharmacotherapeutics. Credit Types: The following are being offered for this activity: Nurse Practitioner: ANCC contact hours Pharmacy: ACPE application-based contact hours Physician: ACCME AMA PRA Category 1 Credits ™ Physician Associate: AAPA Category 1 CME credits Psychology: APA CE credits Social Work: ASWB-ACE CE credits Non-Physician Member of the Healthcare Team: Certificate of Participation stating the program is designated for AMA PRA Category 1 Credits™ Peer Review: The content was peer-reviewed by an MD specializing in psychiatry to ensure the scientific accuracy and medical relevance of information presented and its independence from commercial bias. NEI takes responsibility for the content, quality, and scientific integrity of this CME/CE activity. Disclosures: All individuals in a position to influence or control content are required to disclose any relevant financial relationships. Potential conflicts of interest are identified and mitigated prior to the activity being planned, developed, or presented. Interviewer Andrew J. Cutler, MD Clinical Associate Professor, Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY Chief Medical Officer, Neuroscience Education Institute, Carlsbad, CA Consultant/Advisor: AbbVie, Acadia, Alfasigma, Alkermes, Axsome, Biogen, BioXcel, Boehringer Ingelheim, Cerevel, Corium, Intra-Cellular, Ironshore, Janssen, Jazz, Karuna, Neumora, Neurocrine, Noven, Otsuka, Relmada, Sage Therapeutics, Sunovion, Supernus, Teva, Tris Pharma, VistaGen Therapeutics Speakers Bureau: AbbVie, Acadia, Alkermes, Axsome, BioXcel, Corium, Intra-Cellular, Ironshore, Janssen, Jazz, Lundbeck, Neurocrine, Noven, Otsuka, Sunovion, Supernus, Takeda, Teva, Tris Pharma Interviewee Vladimir Maletic, MD, MS Clinical Professor, Department of Psychiatry and Behavioral Science, University of South Carolina School of Medicine Greenville, SC Consultant/ Advisor: AbbVie, Acadia, Alfasigma, Alkermes, Biogen/Sage, Boehringer Ingelheim, Cervel, Intra-Cellular, Janssen, Jazz, Lundbeck, Neurelis, Neumora, Noven, Otsuka, Pax Medica, Relmada, Sunovion, Supernus, Takeda Speakers Bureau: AbbVie, Alfasigma, Alkermes, Axsome, Corium, Intracellular, Janssen, Lundbeck, Otsuka, Sunovion, Supernus, Takeda Pre-Interview Author Caroline L. O'Brien, MS Assistant Manager, Grant Development, Neuroscience Education Institute, Carlsbad, CA No financial relationships to disclose. The Planning Committee, Content Editor, and Peer Reviewer have no financial relationships to disclose. Disclosure of Off-Label Use: This educational activity may include discussion of unlabeled and/or investigational uses of agents that are not currently labeled for such use by the FDA. Please consult the product prescribing information for full disclosure of labeled uses. Cultural Linguistic Competencies and Implicit Bias: A variety of resources addressing cultural and linguistic competencies and strategies for understanding and reducing implicit bias can be found in this handout—download me. Support: This activity is supported by an unrestricted educational grant from Takeda. Released: November 29, 2023      CME/CE credit expires: November 29, 2026

Part 1 - This is a big deal - in this episode we discuss the first 10+ reasons and benefits of getting intracellular micronutrient testing. Can you reverse diabetes, relieve neuropathy, grow thicker hair, and balance hormones form proper supplementation? Yes, but only with the guidance of intracellular micronutrient levels through a CMA test. Order today at danpursermd.com

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Journée François Jacob : La vie sociale des microbes - How Intracellular Life Turns Symbiotic Bacteria into PathobiontsIntervenant(s)Olivier Espeli, Chercheur, Centre interdisciplinaire de recherche en biologie (CIRB - « Dynamique des chromosomes ») – DR1 CNRSLes Journées François JacobLes Journées François Jacob, organisées par l'Institut de Biologie du Collège de France, rassemblent chaque année les meilleurs spécialistes français et étrangers autour d'un thème à la pointe des enjeux de la recherche en biologie.Le lauréat du prix Antoine Lacassagne, attribué chaque année par le Collège de France à un chercheur en biologie, est traditionnellement invité à recevoir son prix lors des Journées François Jacob et à y donner un séminaire en relation avec ses travaux.Ces journées sont nommées en l'honneur de François Jacob, titulaire de la chaire Génétique cellulaire du Collège de France (1964-1991), prix Nobel de physiologie ou médecine 1965 avec André Lwoff et Jacques Monod pour la découverte de la régulation génétique de la synthèse des enzymes et des virus.

Are You Glutathione Deficient? Glutathione It's Role in The Human Body. The most valuable and effective glutathione promoters are sea vegetables. Most of them contain glutathione in addition to additional compounds that support its production in the body. Sea vegetables also contain chlorophyll, protein, amino acids, minerals, electrolytes, and numerous plant-based compounds that boost immune response and assist in hormone production, among hundreds of other benefits to the human body (alkalizes, detoxes chemicals and heavy metals, balances hormones and sugar levels, boosts immune responses, etc.). (Glutathione Related Disorders: Do Seaweeds have Potential for Cure). Topics in this episode include: Master Antioxidant & Detoxification Specialist – The Role of Glutathione in the Body Physical Longevity & the Effects of Toxicity on Glutathione Are Glutathione Supplements or Glutathione Supportive Foods Your Best Sources? A List of Glutathione Containing Foods and Food Sources of Glutathione Precursors Nature's Gift of Longevity with Health- https://bhsales.myctfo.com/vie.html Celluvie The Ageless Superfood Solution Check out the video below Scientific Team Develops Anti-Aging Nutraceutical What is GlutathioneGlutathione is a protein, naturally occurring in the body, which supports the protection of cells, tissues and organs from premature aging and illness. Glutathione supports a healthy immune system, cellular energy production and detoxification of the bloodstream. Glutathione, known as the master antioxidant, supports the proper functioning of every single cell in your body, helping it to regain its ability to heal itself. Problem:Glutathione is being depleted from our bodies on a regular basis, and even more in people who are exposed to oxidative stressors such as: smoking, pollution, dietary deficiency, pharmaceuticals, radiation, bacterial and viral infections as well as alcohol consumption. Intracellular glutathione levels, within a cell or cells, appear to be a sensitive indicator of the cell's overall health and its ability to resist toxic challenges. Optimizing glutathione levels has been proposed as a strategy for health promotion and prevention.Theoretically, the body is made up of over 100 trillion cells. Your eyes, nose, skin, heart, liver, fingernails, etc. are all made up of cells. As you are reading this, every second it's estimated over 3 million cells die, and 3 million cells are replicated. You could be either replicating healthy cells or unhealthy cells. Therefore, you could be either speeding the aging process or delaying the aging process.CELLUVie® supports the elimination of free radicals within your cells to help regenerate healthy cells. The CELLUVie® Superfood SolutionCELLUVie® is Undenatured, Biogenic Whey Protein Isolate and a Glutathione Precursor. CELLUVie® acts as a precursor, a chemical reaction that produces another compound, supporting the increase of intracellular glutathione which helps regulate the immune system and is known as a primary antioxidant and helps detoxify cells.The scientific team, backed by 20 years of knowledge, developed a unique proprietary process that supports the balance of specific peptides,supports the balance of specific peptides, formulated with the important role of protecting cells, tissues and organs from premature aging.This makes CELLUVie® a well-balanced protein peptide superfood for maintaining youthful energetic cells. CELLUVie® is a tri-peptide complex made from minimally processed, fresh dairy whey. It is one of the highest pharmaceutical-grade whey protein isolates on the market today with many people reporting positive personal anecdotes. It remains a natural product with no side effects.Your tomorrow is determined by the health of your cells TODAY. GLUTATHIONE HAS FOUR MAJOR FUNCTIONS:• ANTIOXIDANT• IMMUNE SYSTEM ENHANCER• DETOXIFIER• RADIATION PROTECTION --- Send in a voice message: https://podcasters.spotify.com/pod/show/bhsales/message

In this podcast, Dr. Paul Morgan, Head of DMPK at Grünenthal Group, discusses the development of the publication that introduced the “5R framework” and improved the likelihood of AstraZeneca candidate survival from candidate drug nomination to Phase III. We will then discuss how the area has developed since then and where the field may go in the future.The episode addresses the following questions:What was the situation like that led to the development of the 5Rs?How was the analysis conducted?How was this analysis accepted both within the organization and externally?What changes occurred as a result of this?As we sit here today has this work led to the improvements suggested?What do you see as the future? Have we done enough? What else is needed?Speaker:Paul Morgan, Ph.D. - Head of DMPK at Grünenthal GroupDr Paul Morgan has worked in Pharma R&D for 30 years across multiple therapeutic areas taking projects from early discovery through all stages of drug development and registration.  With specialism in Drug Metabolism and Pharmacokinetics (DMPK), he has led R&D departments in Pfizer, AstraZeneca, Sosei Heptares and now Grunenthal working across the interface between DMPK and Med Chem, Pharmacology, Safety, Clinical and CMC.  He has a keen interest in R&D productivity enhancement and has contributed to major initiatives at both Pfizer and AstraZeneca to introduce frameworks for the improvement of drug survival.   Paul is an honorary senior lecturer in Department of Pharmacology at University of Liverpool where he did his PhD.   Paul is originally from Belfast, Northern Ireland and is currently based in North-West England just outside Manchester.  He is married with two grown-up children and a lively dog!References:Morgan, P., et al, 2018. Impact of a five-dimensional framework on R&D productivity at AstraZeneca. Nature reviews Drug discovery 17.3: 167-181.Summerfield, S.G., Yates, J.W. and Fairman, D.A., 2022. Free Drug Theory–No Longer Just a Hypothesis?. Pharmaceutical Research, 39(2): 213-222. Smith, D.A., and Rowland, M., 2019. Intracellular and intraorgan concentrations of small molecule drugs: theory, uncertainties in infectious diseases and oncology, and promise. Drug Metabolism and Disposition 47.6: 665-672.Smith, D.A., Di, L. and Kerns, E.H., 2010. "The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery." Nature reviews Drug discovery, 9.12: 929-939.Stay tuned for more podcasts in our Pharmaron DMPK Insights Series!

Join us as we dive deep into the five most critical deficiencies you'd want to avoid. We'll explore the symptoms associated with each and discuss how addressing these intracellular imbalances can pave the way for optimal health. Don't miss this enlightening session!

Named Scientist of the Year in 2001 for her work in BioAcoustic Biology Sharry Edwards (Sharry Edwards™) is the pioneer in the study of Human BioAcoustic Biology. Her 30 years of research is being used at the Institute of BioAcoustic Biology. Currently, Edwards and her team at Sound Health are using human voice and the associated frequencies to help clients resolve health issues such as: macular degeneration, multiple sclerosis, headaches, muscle stress, brain trauma, weight issues and nutritional concerns. The technology she brings to the stage is cutting edge! This technology can identify health and well-being possibilities that you have never encountered.  According to Edwards, "BioAcoustics Voice Spectral Analysis can detect hidden or underlying stresses in the body that are expressed as disease." The vocal print can identify toxins, pathogens and nutritional supplements that are too low or too high. In addition, vocal print can be used to match the most compatible treatment remedy to each client. More information: Sound Health Portal 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.24.550379v1?rss=1 Authors: Stephens, E. B., Henke, W., Kalamvoki, M. Abstract: The open reading frame 3a (ORF3a) is an accessory transmembrane protein that is important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (Yxx{Phi}; where x is any amino acid and {Phi} is a hydrophobic amino acid with a bulky -R group). They have been implicated in the trafficking of membrane proteins to the cell plasma membrane and to intracellular organelles. Previous studies have indicated that mutation of the 160YSNV163 motif abrogated plasma membrane expression and inhibited ORF3a-induced apoptosis. However, two additional canonical tyrosine-based sorting motifs (211YYQL213, 233YNKI236) exist in the cytoplasmic domain of ORF3a that have not been assessed. We removed all three potential tyrosine-based motifs and systematically restored them to assess the importance of each motif or combination of motifs that restored efficient trafficking to the cell surface and lysosomes. Our results indicate that the Yxx{Phi} motif at position 160 was insufficient for the trafficking of ORF3a to the cell surface. Our studies also showed that ORF3a proteins with an intact Yxx{Phi} at position 211 or at 160 and 211 were most important. We found that ORF3a cell surface expression correlated with the co-localization of ORF3a with LAMP-1 near the cell surface. These results suggest that Yxx{Phi} motifs within the cytoplasmic domain may act cooperatively in ORF3a transport to the plasma membrane and endocytosis to lysosomes. Further, our results indicate that certain tyrosine mutants failed to activate caspase 3 and did not correlate with autophagy functions associated with this protein. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.19.549752v1?rss=1 Authors: Dong, B., Mahapatra, S., Clark, M. G., Carlsen, M., Mohn, K. J., Ma, S., Brasseale, K., Crim, G., Zhang, C. Abstract: Controlling chemical processes in live cells is a challenging task. The spatial heterogeneity of biochemical reactions in cells is often overlooked by conventional means of incubating cells with desired chemicals. A comprehensive understanding of spatially diverse biochemical processes requires precise control over molecular activities at the subcellular level. Herein, we develop a closed-loop optoelectronic control system that allows the manipulation of biomolecular activities in live cells at high spatiotemporal precision. Chemical-selective fluorescence signals are utilized to command lasers that trigger specific chemical reactions or control the activation of photoswitchable inhibitors at desired targets. We demonstrate the capability to selectively produce reactive oxygen species (ROS) solely at targeted organelles using blue light. Notably, the induction of ROS in the endoplasmic reticulum leads to a more pronounced disruption of tubulin polymerization and a reduction in green fluorescent protein signals, in comparison to that in lipid droplets. Moreover, when combined with a photoswitchable inhibitor, we selectively inhibit tubulin polymerization within subcellular compartments. This technology enables spatiotemporal control over chemical processes and drug activities, exclusively at desired targets, while minimizing undesired effects on non-targeted locations. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.18.549465v1?rss=1 Authors: Alfonsa, H., Vyazovskiy, V. V., Akerman, C. Abstract: Neural plasticity varies depending on the time of day and preceding sleep-wake history. It is unclear however, how diurnal changes in cellular physiology modulate a neuron's propensity to exhibit synaptic plasticity. Recently it has been shown that cortical pyramidal neurons exhibit diurnal changes in their transmembrane chloride gradients, which shift the equilibrium potential for GABAA receptors (EGABAA). Here we demonstrate that diurnal EGABAA affects membrane potential dynamics and glutamatergic long-term potentiation (LTP) elicited by high-frequency spiking activity in pyramidal neurons of mouse cortex. More depolarized EGABAA values associated with the active period facilitate LTP induction by promoting residual depolarization during synaptically-evoked spiking. Diurnal differences in LTP can be reversed by switching the EGABAA-dependent effects on membrane potential dynamics, either by direct current injection or pharmacologically altering EGABAA. These findings identify EGABAA as a metaplastic regulator of glutamatergic synaptic potentiation, which has implications for understanding synaptic plasticity during waking and sleep. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.18.548845v1?rss=1 Authors: Penjweini, R., Pasut, A., Roarke, B., Alspaugh, G., Sackett, D. L., Knutson, J. R. Abstract: Molecular oxygen (O2) is one of the most functionally relevant metabolites. O2 is essential for mito-chondrial aerobic respiration. Changes in O2 affect muscle metabolism and play a critical role in the maintenance of skeletal muscle mass, with lack of sufficient O2 resulting in detrimental loss of muscle mass and function. How exactly O2 is used by muscle cells is less known, mainly due to the lack of tools to address O2 dynamics at the cellular level. Here we discuss a new imaging method for the real time quantification of intracellular O2 in muscle cells based on a genetically encoded O2-responsive sensor, Myoglobin-mCherry. We show that we can spatially resolve and quantify intracellular O2 con-centration in single muscle cells and that the spatiotemporal O2 gradient measured by the sensor is linked to, and reflects, functional metabolic changes occurring during the process of muscle differentia-tion. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.21.546029v1?rss=1 Authors: Yamasaki, T., Mori, W., Ohkubo, T., Hiraishi, A., Zhang, Y., Kurihara, Y., Nengaki, N., Tashima, H., Fujinaga, M., Zhang, M.-R. Abstract: Intracellular pH (pHi) is a valuable index for predicting hypoxic brain damage. However, no positron emission tomography (PET) probe is currently available for monitoring pHi in vivo. In this study, we developed a new approach for visualizing monoacylglycerol lipase (MAGL) activity in the brain. This approach used PET with a new probe [11C]HC-A, an azetidine carbamate inhibitor, whose uptake and residence depended on the pHi gradient was evaluated with in silico, in vitro, and in vivo assessments. Molecular dynamics simulations predicted that complex (complex-A) between HC-A and MAGL would be difficult to hydrolyze under acidic conditions. In vitro assessment using rat brain homogenate showed that [11C]HC-A reacted with MAGL to yield [11C]complex-A, which was rapidly hydrolyzed to liberate 11CO2. The 11CO2 liberation rate was slower at lower pH. In PET with [11C]HC-A using ischemic rats, the radioactivity clearance rate, which reflects the production rate of 11CO2 in the brain, was lower in a remarkably hypoxic area than in the contralateral region. In conclusion, we successfully visualized the pHi gradient in the brain using PET imaging. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.04.537313v1?rss=1 Authors: Hellweg, L., Pfeifer, M., Chang, L., Tarnawski, M., Bergner, A., Kress, J., Hiblot, J., Reinhardt, J., Johnsson, K., Leippe, P. Abstract: Aspartate is a limiting metabolite in proliferating cells with its production closely linked to glutamine and mitochondrial metabolism. To date, measuring aspartate concentrations in live cells was deemed impossible. We present iAspSnFR, a genetically-encoded biosensor for intracellular aspartate, engineered by displaying and screening biosensor libraries in HEK293 cells. In live cells, iAspSnFR exhibits a dynamic range of 130% fluorescence change and detects reduced aspartate levels upon glutamine deprivation or glutaminase inhibition. Furthermore, iAspSnFR tracks aspartate uptake by excitatory amino acid transporters, or of asparagine after co-expression of an asparaginase. Importantly, iAspSnFR reports aspartate depletions upon electron transport chain inhibition, and therefore it can serve as a proxy for mitochondrial respiration. Consequently, iAspSnFR can dissect the major cellular pathways of aspartate production, offering immediate applications, particularly in cancer biology, such as screening small molecules targeting aspartate and glutamine metabolism. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.22.533138v1?rss=1 Authors: Sigaeva, A., Zijlema, E., Zhang, Y., Schirhagl, R. Abstract: Fluorescent nanodiamonds have exceptional optical properties and are highly biocompatible, which allows to use them as labels for long-term tracking of the cells. The research fields that make use of this application of nanodiamonds include stem cell biology and cancer biology, where quiescent and differentiating cells can be traced in vitro and in vivo. However, these studies focus on using nanodiamonds as simple labels, whereas they can serve as highly sensitive intracellular sensors for free radical species. In this chapter, we aimed to bring the two approaches together and to assess the free radical production in the cells over the course of their differentiation. We report on the successful enterocytic differentiation of HT-29 colon adenocarcinoma cells, pre-loaded with fluorescent nanodiamonds. The cells were cultured in butyrate-free or butyrate-supplemented medium for 13 days. Butyrate-treated cells developed the morphological and molecular traits, characteristic for the normal enterocytes. Fluorescent nanodiamonds did not have a negative effect on the process of differentiation. Moreover, the particles could be found in the cytoplasm of both undifferentiated and re-differentiated cells even after 13 days of culture. The internalized nanodiamonds were used to assess the free radical load in the undifferentiated and re-differentiated HT-29 cells at different stages of the experiment. Consistently with previous findings, re-differentiated HT-29 cells showed higher free radical load than undifferentiated ones. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Both EMFs And Various Chemicals Can Act To Increase Intracellular Calcium In The Developing Brain Dr Martin Pall • https://www.researchgate.net/profile/Martin-Pall• Book – Explaining Unexplained Illness #MartinPall#ChronicFatigueSyndrome #ChemicalExposure Dr Martin Pall is an author. He has a Bachelor of Arts in physics and earned his PhD in biochemistry and genetics from Caltech. Dr Pall was professor of biochemistry and basic medical sciences at Washington State Universityand has published on Chronic Fatigue Syndrome.  He retired from that position in 2008 since when he has researched on multiple chemical sensitivity and published papers on the effect of low intensity microwave frequency electromagnetic fields on the human body. He has been a critic of the expansion of 5G mobile phone networks and the use of wireless technology generally, believing the technology has negative consequences for human health. His Book, Explaining “Unexplained Illnesses”, Discovers the answer to the mysteries of these debilitating illnesses This book  provides long-sought explanations for the properties of chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), fibromyalgia, and posttraumatic stress disorder.  This groundbreaking book examines common symptoms and signs; short-term stressors such as infection, chemical exposure, physical trauma, and severe psychological stress;  why people are often diagnosed as having more than one of these illnesses, and approaches for treating the cause of each disease, rather than the symptoms Explaining "Unexplained Illnesses" provides answers to these questions: • how do short-term stressors initiate chronic illness?• how does the biochemistry of the NO/ONOO- cycle produce chronic illness?• how can the diverse symptoms and signs of these illnesses be generated as a consequence of their common biochemistry?• why is there so much variation in symptoms from one sufferer to another?• what are the principles underlying the NO/ONOO- cycle mechanism?• how does the NO/ONOO- cycle provide explanations for a dozen previously unexplained properties of these illnesses?• how might 14 additional illnesses/diseases also be caused by the NO/ONOO- cycle etiology? Explaining “Unexplained Illnesses” is a must-read for physicians and scientists, and for anyone who suffers from-or knows someone who suffers from—these previously puzzling illnesses. To Contact Martin Pall go tohttps://www.researchgate.net/profile/Martin-Pall Disclaimer:Medical and Health information changes constantly. Therefore, the information provided in this podcast should not be considered current, complete, or exhaustive. Reliance on any information provided in this podcast is solely at your own risk. The Real Truth About Health does not recommend or endorse any specific tests, products, procedures, or opinions referenced in the following podcasts, nor does it exercise any authority or editorial control over that material. The Real Truth About Health provides a forum for discussion of public health issues. The views and opinions of our panelists do not necessarily reflect those of The Real Truth About Health and are provided by those panelists in their individual capacities. The Real Truth About Health has not reviewed or evaluated those statements or claims. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.27.530266v1?rss=1 Authors: Raj, D., Nair, A. V., Sharma, J., Prakash, S., Kaushik, A., Basu, S., Sahu, S., Singh, S., Bhosale, V., Chandra, T., Ghoshal, U. C., Dasgupta, A., Siddiqi, M. I., Gupta, S. K., Chakravortty, D., Ammanathan, V., LAHIRI, A. Abstract: Intracellular Salmonella resides and multiplies in cholesterol-rich specialized compartment called Salmonella-containing vacuoles (SCVs) and avoids fusion with acidic lysosomes. Given, lysosomes are primary organelle that redistributes LDL derived cholesterol to other organelles; we questioned how lysosomal cholesterol can be transported to SCV. We demonstrate here that peroxisomes are recruited to SCVs in human primary macrophages, epithelial cells and functions as pro-bacterial organelles. Further, this interaction is assisted by SseI, a Salmonella effector protein containing mammalian peroxisome targeting sequence. SseI localizes to peroxisome, interacts and activates a host Ras GTPase, ARF-1 on the peroxisome membrane. Activation of ARF-1 leads to recruitment of phosphatidylinsolitol-5-phosphate-4 kinase to generate phosphatidylinsolitol-4-5-bisphosphate on peroxisomes. Accordingly, the {Delta}sseI strain showed reduced virulence in cell lines and during mice infection. Taken together, our work identified a fascinating mechanism by which a pathogen targets host organelles via its secretory effectors and exploits host metabolic intermediates for its intracellular proliferation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.17.528983v1?rss=1 Authors: Fameli, N., van Breemen, C., Groschner, K. Abstract: Specificity of control over virtually all essential cellular functions by Ca2+ is based on the existence of separated, autonomic signaling modules. Spatiotemporal definition of Ca2+ signals involves the assembly of signaling complexes within the nano-architecture of contact sites between the sarco/endoplasmic (SR/ER) reticulum and the plasma membrane (PM). While the requirement of precise spatial assembly and positioning of the junctional signaling elements is well documented, the role of the nano-scale membrane architecture itself, as an ion reflecting confinement of the signaling unit, remains as yet elusive. Utilizing the NCX1/SERCA2-mediated ER Ca2+ refilling process as a junctional signalling paradigm, we provide here the first evidence for an indispensable cellular function of the junctional membrane architecture. Our stochastic modeling approach demonstrates that junctional ER Ca2+ refilling operates exclusively at nano-scale membrane spacing, with a strong inverse relationship between junctional width and signaling efficiency. Our model predicts a breakdown of junctional Ca2+ signaling with loss of reflecting membrane confinement, irrespective of the spatial positioning of the molecular signaling elements. Alterations in the molecular and nano-scale membrane organization at organelle-PM contacts are suggested as new concept in pathophysiology. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

What's actually going on in a cell–or on the spiky outside of an invading virus? Gael McGill, Director of Molecular Visualization at the Center for Molecular and Cellular Dynamics at Harvard Medical School is founder and CEO of Digizyme and has spent his career exploring and developing different modes for visualizing evidence. For this scientific conversation taped back in 2021, Recall this Book host John is joined once again by Brandeis neuroscientist Gina Turrigiano (think ep 4 Madeline Miller; think ep 2 Addiction!). You may want to check out Digizyme‘s images of the spike protein attaching the SARS-CoV2 virus to a hapless cell and fusing their membranes. Or click through to watch a gorgeous video Gael and his team have created. Mentioned in the Episode: Gael praised Galileo's revolutionary images (drawings? diagrams?) of Jupiter's moons: Leonardo's stunning anatomical drawings: The DNA Double-Helix: We all knew that Watson and Crick‘s revelation came with this model: But it's easy to forget this indispensable antecedent: the enigmatic yet foundational x-ray crystallography of Rosalind Franklin: “All models are wrong; some are useful.”smiley statistician George Box “A picture held us captive. And we could not get outside it, for it lay in our language and language seemed to repeat it to us inexorably.” Ludwig Wittgenstein, Philosophical Investigations, 115 And what sort of deceptive picture did Wittgenstein have in mind? well, how about the 1904 “Plum-pudding model” of what the atom might look like? Wrong, and productive of all sorts of mistaken hypotheses. Gina credited the beautiful drawings of Santiago Ramón y Cajal with inspiring and illuminating generations of neuroscientists. John credits Science in the Marketplace, an edited collection reminding us that even in crowded lecture-halls, to display science may also mean doing science….. Gael ended his historical tour by praising David Goodsell, cell-painter extraordinaire: John also raved (as he is wont to do) about cave paintings as the first animation in the world (e.g. these horses from Peche-Merle). Listen and Read Here: 47 Glimpsing COVID: Gael McGill on Data Visualization Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

What's actually going on in a cell–or on the spiky outside of an invading virus? Gael McGill, Director of Molecular Visualization at the Center for Molecular and Cellular Dynamics at Harvard Medical School is founder and CEO of Digizyme and has spent his career exploring and developing different modes for visualizing evidence. For this scientific conversation taped back in 2021, Recall this Book host John is joined once again by Brandeis neuroscientist Gina Turrigiano (think ep 4 Madeline Miller; think ep 2 Addiction!). You may want to check out Digizyme‘s images of the spike protein attaching the SARS-CoV2 virus to a hapless cell and fusing their membranes. Or click through to watch a gorgeous video Gael and his team have created. Mentioned in the Episode: Gael praised Galileo's revolutionary images (drawings? diagrams?) of Jupiter's moons: Leonardo's stunning anatomical drawings: The DNA Double-Helix: We all knew that Watson and Crick‘s revelation came with this model: But it's easy to forget this indispensable antecedent: the enigmatic yet foundational x-ray crystallography of Rosalind Franklin: “All models are wrong; some are useful.”smiley statistician George Box “A picture held us captive. And we could not get outside it, for it lay in our language and language seemed to repeat it to us inexorably.” Ludwig Wittgenstein, Philosophical Investigations, 115 And what sort of deceptive picture did Wittgenstein have in mind? well, how about the 1904 “Plum-pudding model” of what the atom might look like? Wrong, and productive of all sorts of mistaken hypotheses. Gina credited the beautiful drawings of Santiago Ramón y Cajal with inspiring and illuminating generations of neuroscientists. John credits Science in the Marketplace, an edited collection reminding us that even in crowded lecture-halls, to display science may also mean doing science….. Gael ended his historical tour by praising David Goodsell, cell-painter extraordinaire: John also raved (as he is wont to do) about cave paintings as the first animation in the world (e.g. these horses from Peche-Merle). Listen and Read Here: 47 Glimpsing COVID: Gael McGill on Data Visualization Learn more about your ad choices. Visit megaphone.fm/adchoices

What's actually going on in a cell–or on the spiky outside of an invading virus? Gael McGill, Director of Molecular Visualization at the Center for Molecular and Cellular Dynamics at Harvard Medical School is founder and CEO of Digizyme and has spent his career exploring and developing different modes for visualizing evidence. For this scientific conversation taped back in 2021, Recall this Book host John is joined once again by Brandeis neuroscientist Gina Turrigiano (think ep 4 Madeline Miller; think ep 2 Addiction!). You may want to check out Digizyme‘s images of the spike protein attaching the SARS-CoV2 virus to a hapless cell and fusing their membranes. Or click through to watch a gorgeous video Gael and his team have created. Mentioned in the Episode: Gael praised Galileo's revolutionary images (drawings? diagrams?) of Jupiter's moons: Leonardo's stunning anatomical drawings: The DNA Double-Helix: We all knew that Watson and Crick‘s revelation came with this model: But it's easy to forget this indispensable antecedent: the enigmatic yet foundational x-ray crystallography of Rosalind Franklin: “All models are wrong; some are useful.”smiley statistician George Box “A picture held us captive. And we could not get outside it, for it lay in our language and language seemed to repeat it to us inexorably.” Ludwig Wittgenstein, Philosophical Investigations, 115 And what sort of deceptive picture did Wittgenstein have in mind? well, how about the 1904 “Plum-pudding model” of what the atom might look like? Wrong, and productive of all sorts of mistaken hypotheses. Gina credited the beautiful drawings of Santiago Ramón y Cajal with inspiring and illuminating generations of neuroscientists. John credits Science in the Marketplace, an edited collection reminding us that even in crowded lecture-halls, to display science may also mean doing science….. Gael ended his historical tour by praising David Goodsell, cell-painter extraordinaire: John also raved (as he is wont to do) about cave paintings as the first animation in the world (e.g. these horses from Peche-Merle). Listen and Read Here: 47 Glimpsing COVID: Gael McGill on Data Visualization Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

What's actually going on in a cell–or on the spiky outside of an invading virus? Gael McGill, Director of Molecular Visualization at the Center for Molecular and Cellular Dynamics at Harvard Medical School is founder and CEO of Digizyme and has spent his career exploring and developing different modes for visualizing evidence. For this scientific conversation taped back in 2021, Recall this Book host John is joined once again by Brandeis neuroscientist Gina Turrigiano (think ep 4 Madeline Miller; think ep 2 Addiction!). You may want to check out Digizyme‘s images of the spike protein attaching the SARS-CoV2 virus to a hapless cell and fusing their membranes. Or click through to watch a gorgeous video Gael and his team have created. Mentioned in the Episode: Gael praised Galileo's revolutionary images (drawings? diagrams?) of Jupiter's moons: Leonardo's stunning anatomical drawings: The DNA Double-Helix: We all knew that Watson and Crick‘s revelation came with this model: But it's easy to forget this indispensable antecedent: the enigmatic yet foundational x-ray crystallography of Rosalind Franklin: “All models are wrong; some are useful.”smiley statistician George Box “A picture held us captive. And we could not get outside it, for it lay in our language and language seemed to repeat it to us inexorably.” Ludwig Wittgenstein, Philosophical Investigations, 115 And what sort of deceptive picture did Wittgenstein have in mind? well, how about the 1904 “Plum-pudding model” of what the atom might look like? Wrong, and productive of all sorts of mistaken hypotheses. Gina credited the beautiful drawings of Santiago Ramón y Cajal with inspiring and illuminating generations of neuroscientists. John credits Science in the Marketplace, an edited collection reminding us that even in crowded lecture-halls, to display science may also mean doing science….. Gael ended his historical tour by praising David Goodsell, cell-painter extraordinaire: John also raved (as he is wont to do) about cave paintings as the first animation in the world (e.g. these horses from Peche-Merle). Listen and Read Here: 47 Glimpsing COVID: Gael McGill on Data Visualization Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science-technology-and-society

What's actually going on in a cell–or on the spiky outside of an invading virus? Gael McGill, Director of Molecular Visualization at the Center for Molecular and Cellular Dynamics at Harvard Medical School is founder and CEO of Digizyme and has spent his career exploring and developing different modes for visualizing evidence. For this scientific conversation taped back in 2021, Recall this Book host John is joined once again by Brandeis neuroscientist Gina Turrigiano (think ep 4 Madeline Miller; think ep 2 Addiction!). You may want to check out Digizyme‘s images of the spike protein attaching the SARS-CoV2 virus to a hapless cell and fusing their membranes. Or click through to watch a gorgeous video Gael and his team have created. Mentioned in the Episode: Gael praised Galileo's revolutionary images (drawings? diagrams?) of Jupiter's moons: Leonardo's stunning anatomical drawings: The DNA Double-Helix: We all knew that Watson and Crick‘s revelation came with this model: But it's easy to forget this indispensable antecedent: the enigmatic yet foundational x-ray crystallography of Rosalind Franklin: “All models are wrong; some are useful.”smiley statistician George Box “A picture held us captive. And we could not get outside it, for it lay in our language and language seemed to repeat it to us inexorably.” Ludwig Wittgenstein, Philosophical Investigations, 115 And what sort of deceptive picture did Wittgenstein have in mind? well, how about the 1904 “Plum-pudding model” of what the atom might look like? Wrong, and productive of all sorts of mistaken hypotheses. Gina credited the beautiful drawings of Santiago Ramón y Cajal with inspiring and illuminating generations of neuroscientists. John credits Science in the Marketplace, an edited collection reminding us that even in crowded lecture-halls, to display science may also mean doing science….. Gael ended his historical tour by praising David Goodsell, cell-painter extraordinaire: John also raved (as he is wont to do) about cave paintings as the first animation in the world (e.g. these horses from Peche-Merle). Listen and Read Here: 47 Glimpsing COVID: Gael McGill on Data Visualization Learn more about your ad choices. Visit megaphone.fm/adchoices

What's actually going on in a cell–or on the spiky outside of an invading virus? Gael McGill, Director of Molecular Visualization at the Center for Molecular and Cellular Dynamics at Harvard Medical School is founder and CEO of Digizyme and has spent his career exploring and developing different modes for visualizing evidence. For this scientific conversation taped back in 2021, Recall this Book host John is joined once again by Brandeis neuroscientist Gina Turrigiano (think ep 4 Madeline Miller; think ep 2 Addiction!). You may want to check out Digizyme‘s images of the spike protein attaching the SARS-CoV2 virus to a hapless cell and fusing their membranes. Or click through to watch a gorgeous video Gael and his team have created. Mentioned in the Episode: Gael praised Galileo's revolutionary images (drawings? diagrams?) of Jupiter's moons: Leonardo's stunning anatomical drawings: The DNA Double-Helix: We all knew that Watson and Crick‘s revelation came with this model: But it's easy to forget this indispensable antecedent: the enigmatic yet foundational x-ray crystallography of Rosalind Franklin: “All models are wrong; some are useful.”smiley statistician George Box “A picture held us captive. And we could not get outside it, for it lay in our language and language seemed to repeat it to us inexorably.” Ludwig Wittgenstein, Philosophical Investigations, 115 And what sort of deceptive picture did Wittgenstein have in mind? well, how about the 1904 “Plum-pudding model” of what the atom might look like? Wrong, and productive of all sorts of mistaken hypotheses. Gina credited the beautiful drawings of Santiago Ramón y Cajal with inspiring and illuminating generations of neuroscientists. John credits Science in the Marketplace, an edited collection reminding us that even in crowded lecture-halls, to display science may also mean doing science….. Gael ended his historical tour by praising David Goodsell, cell-painter extraordinaire: John also raved (as he is wont to do) about cave paintings as the first animation in the world (e.g. these horses from Peche-Merle). Listen and Read Here: 47 Glimpsing COVID: Gael McGill on Data Visualization Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527921v1?rss=1 Authors: Stephan, G., Liu, W., Frenster, J., Ravn-Boess, N., Bready, D., Cai, J., Fenyo, D., Neubert, T. A., Placantonakis, D. Abstract: GPR133 (ADGRD1) is an adhesion G protein-coupled receptor that signals through Gas and is required for growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely understood. Here, we use proximity biotinylation proteomics to identify ESYT1, a Ca2+-dependent mediator of endoplasmic reticulum-plasma membrane bridge formation, as an intracellular interactor of GPR133. ESYT1 knockdown or knockout increases GPR133 signaling, while its overexpression has the opposite effect, without altering GPR133 levels in the plasma membrane. The GPR133-ESYT1 interaction requires the Ca2+-sensing C2C domain of ESYT1. Thapsigargin-mediated increases in cytosolic Ca2+ relieve signaling-suppressive effects of ESYT1 by promoting ESYT1-GPR133 dissociation. ESYT1 knockdown or knockout in GBM impairs tumor growth in vitro, suggesting functions of ESYT1 beyond the interaction with GPR133. Our findings suggest a novel mechanism for modulation of GPR133 signaling by increased cytosolic Ca2+, which reduces the signaling-suppressive interaction between GPR133 and ESYT1 to raise cAMP levels. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Gerald Maguire is the world's frontrunner in pharmacological treatment research for stuttering. His personal connection with stuttering, academic background, professional experience and international links with top scientists have positioned him as the leading expert on medication's future role in the treatment of stuttering. Dr. Maguire is a professor and Founding Chair of Psychiatry for the American University of Health Sciences School of Medicine in California. He is the principal investigator for CenExel CIT, Global Medical Director for iStutter, and Chair of Research and Development for the World Stuttering Network.Dr. Maguire's disclosures include:Research Grants related to stuttering: Noema, Emalex. Other CNS research grants: Bioexcel, Neurocrine, Jazz, Sunovion, Karuna, Cerevel, Intracellular, Otsuka, AxsomeConsultant/Advisor: Karuna, Sage/Biogen, Noema, EmalexSpeakers' Bureau: Alkermes, Janssen, Otsuka, AxsomeNo medication is FDA approved for stutteringIf you would like to learn more about the Orpheus Study and how to participate, click here: https://www.orpheusstudy.com/WSN

Nik from Rooted Leaf is BACK to continue our individual nutrient explorations- this time focusing on CALCIUM. Nik explains how calcium is absorbed and utilized by the plant, and how cannabis calcium consumption changes throughout the cannabis grow cycle. He goes on to expound on different forms of applicable calcium, and compares the sources based on solubility, nitrogen content, and more. Nik goes on to explain a few mind blowing phenomena involving calcium; the first being the intracellular exchange of calcium - making it pretty agile for an immobile nutrient - and also the production of calcium waves that originate from a point of stress and ripple throughout the plants entire cellular being. Nik also talks about the upcoming INDUSTRY NIGHT and GROW CLASS (with Jordan River speaking) which you can find tickets to at www.rootedleaf.com (code growcast for 20% off products) GrowCast Classes (IL Breeding Workshop on sale now! Living Soil Masterclass coming to MA, and MO!) GrowCast Seed Co (Fems dropping soon!) *Code growcast15 now works with grow KITS from AC Infinity! www.acinfinity.com use promo code growcast15 for 10% off the BEST grow fans in the game, plus tents, pots, scissors, LED lights, and now GROW KITS!*

Why is moisture important in your pet's diet?We talk about the WHY!Makes your body crave moisture when you feed your pet dry kibble, so they drink more. Both dogs and cats.Your pets are designed (think carnivores) to eat food that contains 60-80% moisture.Intracellular moisture is extremely important for the digestive tract, for the proper digestion and breakdown of food nutrients. Without this moisture, in the example of dry food kibble diets, the cat or dog is in a constant state of dehydration. Drinking water from a bowl is not usually sufficient.Historically, cats derive most of the water their bodies needed from their prey. Because dry food has a low moisture content, your cat needs to get water from a dish, fountain or wet food. Feeding a combination of wet and dry food, rather than just dry, is a great way to help your cat get more water.What can you do? Add filtered water (if tap water is something you wouldn't drink it). You can warm up the water and pour it over the food. Or warm up the broth you are using as a pour-over.Flo Glodde After completing her Master's degree in Animal Nutrition and working as a pet nutritionist at a local natural pet supply store, “Crude Carnivore” was born. With an avid interest in nutrition, she has fed her pets Hurley, Marvin, Ovie & Clem the way nature intended for years and now spends every day spreading food awareness to as many pet owners as possible. Flo's Website Join the Wildside for updates and discounts!Learn more about Steve's Real Foods.Learn more about Northwest Naturals.Learn more about Lifetime Pet Wellness Center.We are a local, independent, and owner-operated shop that is committed to providing the dogs and cats in our hometown of Columbus, Ohio with the best possible foods, supplements, and gear available. Also, we're a little different. Our small shop is not your typical pet food store. We don't carry unnecessary pet supplies like a lot of other shops do. We do not saturate our little space with products that we don't believe in and feel are unnecessary. Our goal is to have a place full of positive vibes that you and your pet feel comfortable in.We answer a "question of the week" in every episode, so send your question. Either DM us at @fangsfurpets or send us an email at danielle@fangsfur.com. Find us on Facebook and Instagram.Music in this episode thanks to...Uppbeat: https://uppbeat.io/t/soundroll/fuzz-buzz - License code: LXYRDYTBCUZ8NMUCUppbeat: https://uppbeat.io/t/all-good-folks/habanera-bizet-hip-hop-remix -License code: HGGVZ43LS1MCK8PDCopyright 2022 Fangs & Fur

Named Scientist of the Year in 2001 for her work in BioAcoustic Biology Sharry Edwards (Sharry Edwards™) is the pioneer in the study of Human BioAcoustic Biology. Her 30 years of research is being used at the Institute of BioAcoustic Biology. Currently, Edwards and her team at Sound Health are using human voice and the associated frequencies to help clients resolve health issues such as: macular degeneration, multiple sclerosis, headaches, muscle stress, brain trauma, weight issues and nutritional concerns. The technology she brings to the stage is cutting edge! This technology can identify health and well-being possibilities that you have never encountered.  According to Edwards, "BioAcoustics Voice Spectral Analysis can detect hidden or underlying stresses in the body that are expressed as disease." The vocal print can identify toxins, pathogens and nutritional supplements that are too low or too high. In addition, vocal print can be used to match the most compatible treatment remedy to each client.

References Dr Guerra's lipid lectures Periodicum Biologorum 2011. 113(1):43-49 Obstet Gynecol Sci 2014. v.57(2) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

  In this CME episode, Dr. Andrew Cutler interviews Dr. Vladimir Maletic about novel agents in development for Major Depressive Disorder or MDD. Optional CME/CE Credits and Certificate Instructions: After listening to the podcast, to take the optional posttest and receive CME/CE credit, click: https://nei.global/POD22-MDD. Learning Objectives: After completing this educational activity, you should be better able to: Describe novel mechanisms of action of agents under investigation for the treatment of depression Explain the potential implications of novel rapid-acting and multi-modal agents in optimizing outcomes for patients with unipolar depression Integrate newly available options for depression into clinical practice Accreditation: In support of improving patient care, Neuroscience Education Institute (NEI) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. NEI designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.   A posttest score of 70% or higher is required to receive CME/CE credit. The content in this activity pertains to pharmacology and is worth 1.0 continuing education hour of pharmacotherapeutics. Credit Types. The following are being offered for this activity: Nurse Practitioner: ANCC contact hours Pharmacy: ACPE application-based contact hours Physician: ACCME AMA PRA Category 1 Credits ™ Physician Assistant: AAPA Category 1 CME credits Psychology: APA CE credits Social Work: ASWB-ACE CE credits Non-Physician Member of the Mental Healthcare Team: Certificate of Participation stating the program is designated for AMA PRA Category 1 Credits ™ Peer Review: The content was peer-reviewed by an MD specializing in psychiatry to ensure the scientific accuracy and medical relevance of information presented and its independence from commercial bias. NEI takes responsibility for the content, quality, and scientific integrity of this CME/CE activity. Disclosures: All individuals in a position to influence or control content are required to disclose any relevant financial relationships. Any potential conflicts of interest were identified and mitigated prior to the activity being planned, developed, or presented. InterviewerAndrew J. Cutler, MD Clinical Associate Professor, Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY Chief Medical Officer, Neuroscience Education Institute, Carlsbad, CA Consultant/Advisor: AbbVie/Allergan, Acadia, Alfasigma, Biogen, BioXcel, Boehringer Ingelheim, Corium, Intra-Cellular, Ironshore, Janssen, Jazz, Karuna, Lundbeck, Neurocrine, Noven, Otsuka, Relmada, Sage, Sunovion, Supernus, Teva Speakers Bureau: AbbVie/Allergan, Acadia, Alfasigma, BioXcel, Corium, Intra-Cellular, Ironshore, Janssen, Lundbeck, Neurocrine, Noven, Otsuka, Sunovion, Supernus, Teva   IntervieweeVladimir Maletic, MD, MS Clinical Professor of Psychiatry, University of South Carolina School of Medicine, Greenville, SC Consultant/Advisor: AbbVie, Alfasigma, Alkermes, Biogen/Sage, Intracellular, Ironshore, Janssen, Lundbeck, Otsuka, Relmada, Sunovion, Supernus, Takeda Speakers Bureau: AbbVie, Alfasigma, Alkermes, Biogen/Sage, Intracellular, Ironshore, Janssen, Lundbeck, Otsuka, Sunovion, Supernus, Takeda   Pre-Interview AuthorSabrina K. Bradbury-Segal, PhD Medical Writer, Neuroscience Education Institute, Carlsbad, CA No financial relationships to disclose.   The Planning Committee and Peer Reviewer have no financial relationships to disclose. Disclosure of Off-Label Use: This educational activity may include discussion of unlabeled and/or investigational uses of agents that are not currently labeled for such use by the FDA. Please consult the product prescribing information for full disclosure of labeled uses. Cultural Linguistic Competencies and Implicit Bias: A variety of resources addressing cultural and linguistic competency and strategies for understanding and reducing the impact of implicit bias can be found in this handout. Support: This activity is supported by an unrestricted educational grant from Sage Therapeutics, Inc. Released: September 26, 2022     CME/CE credit expires: September 26, 2025

Herbs are replacing supplements BIG time in the holistic autism recovery community.In this podcast episode with herbalist Allan Hopking, you'll understand why.We cover:The effect of micro-dosing herbs to  RE-EDUCATE the microbiome and combat picky eating.Intracellular healing and how herbs can get rid of intestinal crustation and "starve" diseased cells.The NUMBER ONE multi-functional herbal tincture and powder that should always be in your kitchen cabinet.How herbs can SHIELD each organ and work intracellularly in a way that supplements never will. Herbal shields (this is amazing) for each organ (breast, kidney, liver and sexual organs)The MOST IMPORTANT plant for our immune system and why you should collect it for free.The herbal approach to parasites, Morgellons, worms and how parasites are linked to gallstones/kidney stones.How to cleanse the intestines and detox the liver, intestines, and kidneys.The number one herbal remedies for autism families, cancer, PCOS, viral load, bacteria, infections, addictions and more.LINKS FOR HERBS MENTIONED:USE DISCOUNT CODE: HERBSHIELD:https://www.herbactive.co.uk/shop/herbshield-tonic/ABCD POWDER FOR MICRODOSING:https://www.herbactive.co.uk/shop/abc-daily-herbal-nutripowder-plus/BREASTSHIELD:https://www.herbactive.co.uk/shop/breastshield-tonic/WORMLESShttps://www.herbactive.co.uk/shop/wormless-tonic-now-even-stronger/BLACK SALVEhttps://www.herbactive.co.uk/shop/black-salve-strong-internal-tonic/BLACK SALVE LOTION:https://www.herbactive.co.uk/shop/black-salve-paste-ointment-now-even-stronger/

Yah'ki Awakened is a black-owned, holistic health and wellness business focused on cellular regeneration, DNA repair, and intracellular detoxification using a high energetic diet, powerful alkaline botanicals and natural herbs. Yah'ki – also known as Alexander Hickman – is a Master Herbalist, Holistic Teacher, Crystal Healer, Detoxification Specialist, Reiki Healer, Motivational Speaker, self-taught BioChemist, and community activist.  From former gang member in Illinois to multi-million-dollar business owner, Yah'ki has an incredible story to share on his entrepreneurial journey and education in holistic healing. He has healed thousands of individuals worldwide including celebrities and athletes. His list of products including natural herbs, tinctures, and more can be found at https://yahkiawakened.com/. Some topics we touched on during the podcast include: All things holistic health, wellness, and herbs, especially as it relates to women's health Salt, Sugar, Fat & Protein - the lies of the food industry Awakening - what foods support your process? What are some good herbal/holistic health options for women in general? How can cellular regeneration and DNA repair help women? Intracellular detoxification using a high energetic diet, powerful alkaline botanicals and natural herbs. The importance and spirituality of wo(mb)mens health SHOW LINKS: Website: https://yahkiawakened.com/ Facebook: https://www.facebook.com/YahkiEl YouTube: https://www.youtube.com/channel/UCFHk2xdeKnSG-B1rCt_tkTA?view_as=subscriber Instagram: https://www.instagram.com/yahki_awakened_/?hl=en Shop Eco-friendly & Sustainable fashion use code WITCHY for 20% off your purchase at Blair Lane Co. - www.blairlaneco.com Take the Anxious Personality Type Quiz: https://www.anxioustoaligned.com/quiz evo HEMP products: use code WITCHY for 20% off your purchase!

What Makes The King Herbs of Life a Good Neighbor...The King Herbs of Life is a health and wellness shop catering to the inner and outer beauty. Our focus is on lifestyle change for women men children and families. Health and nutrition are important in our health journey Jhonathan and his team are committed to help you take control over your own health. we shouldn't have to fear getting sick or feel trapped and hopeless to the medical system that address your symptoms with more and more medication. your body is the ultimate technology in its ability to heal itself through diet ,lifestyle change and natural herbal remedies provided by mother nature.The King Herbs of Life has helped hundreds reach their wellness goals and adress countless diseases such as diabetes mellitus, high blood pressure, obesity, anxiety, depression, arthritis , lupus and many more. Our focus is on detoxifying the body through an intra-cellular cleansing. An Intracellular cleanse is a cellular cleanse or rinsing of each cell, this ensures proper nutrition and strengthening of the cells, while cleansing the entire cell matrix, systems and organs that make up the entire human organism. The Colon is the body's sewer system where most of the toxic waste goes . Inside the colon, poisons are created every day from the effects of improper elimination through fermentation and petrification. Once efficient bowel elimination is impaired (2-3 times a day), toxins will accumulate and be absorbed into the bloodstream. Once this happens, these Physiological toxins can circulate throughout the body and clog cells, organs, and function of the system, accumulating in the tissue over time, eventually manifesting in the disease of one way or another. the lack of oxygen being received by the 100 trillion cells that make up your human body is the cause of dis-ease.Jhonathan created the King Herbs of Life for the community to improve their health and wellness. our personal mission is to provide the tools and information to eliminate sickness and suffering caused by pharmaceuticals and chemicals that do not assimilate in the human body. we achieve this through proper nutrition, cellular cleansing and rebuilding the human body through the intake of minerals found in mother nature. Jhonathan and his team is committed to help women, men, children, and families live a happy, healthier and long life through diet and proper education of the human body and its self healing mechanisms.To learn more about The King Herbs of Life, go to: https://www.thekingherbsoflife.com/aboutThe King Herbs of Life886 110th Ave N Naples, Fl34108, Suite 8(239) 431-5286Support the show (https://goodneighborpodcast.com)

My AP Biology Thoughts  Unit 4 Cell Communication and Cell CycleWelcome to My AP Biology Thoughts podcast, my name is Victoria Villagran and I am your host for episode #90 called Unit 4 Cell Communication and Cell Cycle: Cellular Responses in Signaling Pathways. Today we will be discussing general cellular responses in signaling pathways.  Segment 1: Introduction to Cellular Responses in Signaling Pathways Signaling pathway: Signaling begins with the recognition of a chemical messenger, a ligand, by a receptor protein in a target cell The ligand-binding domain of a receptor recognizes a specific chemical messenger, which can be a peptide, a small chemical, or protein, in a specific one-to-one relationship Signal reception, which is when the target cell receives a signaling molecule; transduction, which is a series of events that converts the signal to something the target cell can respond to; and cellular response, which is when the target cell responds to the signal.  They are many varieties of ligands and receptors, and them binding can lead to many different responses  May involved 2nd messengers or phosphorylation, and protein phosphorylation  They all produce some kind of cellular response The same signal or ligand can lead to different responses  Signal Pathways may influence how the cell responds to its environment  Responses can be short or long term We can see changes such as an increase in the transcription of certain genes or the activity of particular enzymes. We may be able to see changes in the outward behavior or appearance of the cell, such as cell growth or cell death, that are caused by the molecular changes Three Response Types 1. Metabolism/Growth/Enzyme Activation/Open Ion Channel Altering the activity of specific enzymes, metabolic enzymes in the cell become more or less active  Activated G Protein binds to a molecule that starts the transduction pathway, we will go into more detail later  Some signals bind to ligand-gated ion channels which either open or close in response to binding  2. Gene Expression The process where information from a gene is used by the cell to produce a functional product, a protein. It involves two steps, transcription and translation. Signaling pathways can target either or both steps to alter the amount of a particular protein produced in a cell. Intracellular receptor: ligands are small or non-polar and can diffuse into the membrane. They are an activated hormone-receptor that can act as a transcription factor and affect gene expression Controlling which genes are expressed or not through a number control mechanisms  3. Apoptosis: programmed cell death in cell cycle (also T cell Recognition) Internal signals (such as those triggered by damaged DNA) can lead to apoptosis, but so can signals from outside the cell.  Segment 2: More About Specific Cellular Responses  Metabolism: Epinephrine  When epinephrine binds to its receptor on a muscle cell (G protein-coupled receptor), it triggers a signal transduction cascade involving production of the second messenger molecule cyclic AMP (cAMP). This cascade leads to phosphorylation of two metabolic enzymes, causing a change in the enzymes' behavior. The first enzyme is glycogen phosphorylase (GP) which breaks down glycogen into glucose. Phosphorylation activates glycogen phosphorylase, causing lots of glucose to be released. The second enzyme that gets phosphorylated is glycogen synthase (GS) and it is involved in building up glycogen, and phosphorylation inhibits its activity.  Through regulation of these enzymes, a muscle cell rapidly gets a large, ready pool of glucose molecules. The glucose is available for use by the muscle cell in response to a sudden surge of adrenaline aka the “fight or flight” response. Apoptosis: External Signaling  Most animal cells have receptors that interact with the...

My AP Biology Thoughts  Unit 4 Cell Communication and Cell CycleWelcome to My AP Biology Thoughts podcast, my name is Pauline Brillouet and I am your host for episode #87 called Unit 4 Cell Communication and Cell Cycle: Reception: Ligand Gated Ion Channels and Intracellular Receptors. Today we will be discussing the function and examples of these two types of receptors. Segment 1: Introduction to Reception: Ligand Gated Ion Channels and Intracellular ReceptorsLigand gated ion channels and intracellular receptors are both involved in the first step of a signaling pathway known as reception. Reception is the process where a signal, or otherwise called a ligand, binds to a receptor. The ligand-binding domain of the receptor recognizes the specific chemical messenger to then start transduction. One thing to note is that the binding of ligand and receptor is noncovalent, so it is temporary and functions like an enzyme-substrate complex where size and shape of the signal is essential.  The main difference between the two receptors we are exploring is their location. Ligand-gated ion channels are membrane proteins. Meaning they are embedded in the membrane. Like the name suggests, intracellular receptors obviously lie within the cell.  Segment 2: More About Reception: Ligand Gated Ion Channels and Intracellular ReceptorsLigand gated ion channels either open or close in response to binding. They conduct ion flow. An example is a neurotransmitter binding to neurons, which opens the gate for Na+ Intracellular receptors require ligands that are small or nonpolar because they can diffuse through the membrane. An example of this is the sex hormone estrogen or any steroid hormone. When a hormone enters a cell and binds to its receptor, it causes the receptor to change shape, allowing the receptor-hormone complex to enter the nucleus (if it wasn't there already) and regulate gene activity Segment 3: Connection to the CourseThe hydrophilic ion channel lets ions cross the membrane without having to touch the hydrophobic core of the https://www.khanacademy.org/science/biology/membranes-and-transport/the-plasma-membrane/a/structure-of-the-plasma-membrane (phospholipid bilayer). Changes in ion levels inside the cell can change the activity of other molecules, such as ion-binding enzymes. The binding of neurotransmitters to neurons is also essential for the entire nervous system and basic brain functions such as attention, learning, and memory.  Intracellular receptors are unique because they cause these changes very directly, binding to the DNA and altering transcription themselves. A very important gas that acts as a ligand that is able to directly diffuse through the membrane is Nitric oxide (NO). It activates a signaling pathway in the smooth muscle surrounding blood vessels, one that makes the muscle relax and allows the blood vessels to expand. Drugs that treat heart diseases release NO to bind to the intracellular receptors and dilate vessels to restore blood flow to the heart. Thank you for listening to this episode of My AP Biology Thoughts. For more student-ran podcasts and digital content, make sure that you visit http://www.hvspn.com (www.hvspn.com). Thank you! Music Credits: "Ice Flow" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License http://creativecommons.org/licenses/by/4.0/ Subscribe to our Podcast https://podcasts.apple.com/us/podcast/my-ap-biology-thoughts/id1549942575 (Apple Podcasts) https://open.spotify.com/show/1nH8Ft9c9f6dmo75V9imCk (Spotify) https://podcasts.google.com/search/my%20ap%20biology%20thoughts (Google Podcasts )   https://www.youtube.com/channel/UC07e_nBHLyc_nyvjF6z-DVg (YouTube)   Connect with us on Social Media Twitterhttps://twitter.com/thehvspn ( @thehvspn)

This is an introduction to the embodiment of the Aries constellation through science and story. Intracellular and extracellular structures mimic she shapes associated with Aries and have similar archetypal functions. 

This episode covers intracellular pathogens!