Podcasts about peptides

Peptides for midlife health are suddenly everywhere, but do they actually work or are they just the newest longevity trend? In this episode, Chalene Johnson sits down with longevity expert Dr. Elizabeth Yurth to break down the growing buzz around peptides and what women over 40 should know before jumping in. You've probably heard about GLP-1 medications, BPC-157, collagen peptides, and growth hormone peptides, all promising benefits for weight loss, inflammation, muscle recovery, and anti-aging. But with so many supplements, injections, and online sources popping up, it's getting harder to tell what's legitimate and what's just hype. Together, Chalene and Dr. Yurth unpack what peptides actually are, why they're suddenly everywhere in the longevity world, and why many experts believe peptide levels change as we age. They also discuss one of the biggest risks most people don't realize until it's too late: where peptides are coming from and why the source matters far more than most people think. If you've been curious about peptides, GLP-1 medications, or longevity therapies for women over 40, this conversation will help you start asking the right questions before deciding whether they belong in your midlife health routine. Check out this video on YouTube

Boss man is BACK! Today I am joined by my coach Christian Chapman and we run through a loaaad of questionsI hope you enjoy, and don't forget to share and tag us on insta @emma.currivan and @christian_physiquepro xoxo⁠⁠⁠⁠⁠CHAT TO ME ABOUT COACHING ON WHATSAPP⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠JOIN MY PATREON HERE⁠⁠⁠⁠⁠⁠⁠ - just 5.99 a month hehe xTo submit a question for a Q&A episode⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠click here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Don't forget to subscribe to my YouTube channel!⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Catch you in the next one xo

These days, many internet influencers are promoting a wellness trend that sounds like something you might remember from high school bio: peptides. They’re being sold as ways to improve skin, reverse aging – basically, peptides have become THE answer to your choice of wellness issues. But most of what’s hawked on Instagram or TikTok is not approved by the FDA. . That could change: Health Secretary Robert F. Kennedy Jr. recently said on Joe Rogan’s podcast that he wants to relax restrictions on many peptides. In the meantime, people are accessing them through methods that some experts say are…. dangerous. Guests: Alex Hogan, a senior multimedia producer at STAT News and the host of STATus Report Related links: Inside the world of internet peptides | STAT News Peptides Are the New Wellness Cure-All | Intelligencer Why 'Anti-Aging' Peptide Shots Are Trending on Social Media | TIME Peptides take off as a DIY treatment but is that a good idea? : NPR Thank you to the supporters of KUOW, you help make this show possible! If you want to help out, go to kuow.org/donate/soundsidenotes Soundside is a production of KUOW in Seattle, a proud member of the NPR Network.See omnystudio.com/listener for privacy information.

See exclusives at https://SarahWestall.Substack.comEddie Conner, one of America's top psychics, returns to the program to share his insights on what may be coming in the near future. Building on themes from our previous conversation, Eddie explains why he believes the pace of major disclosures will accelerate even further during this current Mercury retrograde cycle.We discuss how this period may mark a turning point, as long-hidden information begins to surface and longstanding narratives are challenged. According to Eddie, the world is entering a transformative time where greater transparency could bring long-awaited revelations and begin to correct injustices that have persisted for generations.You can learn more about Eddie and get a personal reading at https://EddieConner.comLinks and Offers Mentioned in the show:Buy quality at Quince.com/BusinessGame - get free shipping and 365-day returns! Now available in Canada too!Buy Anti AgingMUST Sign up as a VIP to see certain peptides like Retatrutide at https://limitlesslifenootropics.com/vip-club-registration/?uid=116&oid=1&affid=10134Buy Exercise Mimicking & Muscle Building Peptide SLU-PP-332 at https://www.limitlesslifenootropics.com/product/slu-pp-332-250mcg-60-capsules/?ref=vbWRE3J
- Use code Sarah to save 15%See the Peptide stack for weight loss stack in the Ultimate Peptide Guide for Weight Loss and Muscle Preservation at https://sarahwestall.substack.com/p/the-ultimate-peptide-guide-for-weightCopyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.Disclaimer: "As a journalist, I report what significant newsmakers are claiming. I do not have the resources or time to fully investigate all claims. Stories and people interviewed are selected based on relevance, listener requests, and by suggestions of those I highly respect. It is the responsibility of each viewer to evaluate the facts presented and then research each story furtherSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

True wellness isn't about chasing symptoms—it's about understanding the internal communication systems that allow the body to repair, adapt, and thrive. In this episode, Dr. Greg Jones is joined by Dr. Kathleen O'Neil-Smith, a Harvard-trained physician and pioneer in peptide therapy, to explore how peptides, mitochondria, and personalized medicine work together to support resilient, long-term health.As a founding board member of the International Peptide Society, Dr. Kathleen explains how small signaling proteins orchestrate large-scale healing by influencing cellular communication, inflammation, metabolic efficiency, and recovery. The conversation highlights why mitochondrial health sits at the foundation of longevity and how modern medicine often overlooks the body's innate capacity to heal.Moving beyond trends and surface-level protocols, Dr. Kathleen shares how peptide therapy integrates with hormones, gut health, nervous system balance, and lifestyle to create durable clinical outcomes. They also discuss why one-size-fits-all medicine consistently fails patients, and how clinicians can think more strategically about restoring resilience rather than suppressing symptoms.

Peptides are everywhere right now—touted as tools for weight loss, muscle growth, faster recovery, and even longevity. But what are they actually, and do they live up to the hype? In this episode of Office Hours, I break down the science behind peptides, how they influence the body's signaling systems, and how to think about them wisely within a functional medicine approach. In this episode, I cover: • How peptides act as signaling molecules that regulate metabolism, repair, appetite, and energy • The major peptide categories people are using today—from GLP-1 medications to growth and longevity peptides • When peptide therapies may be helpful and the situations where caution is important • Why foundational health habits still matter more than any advanced therapy Peptides may represent an exciting frontier in medicine, but they're not shortcuts. They amplify the biological environment you already have. When your foundation is strong, targeted therapies can enhance healing and performance. But when your biology is inflamed, sleep-deprived, or metabolically dysfunctional, no peptide can override that terrain. Health isn't built from hacks—it's built from habits. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year. Have a question you'd love answered on Office Hours? Submit it here

Daisy Wolf speaks with Dr. Andrew Huberman, professor of neurobiology and ophthalmology at Stanford University and host of the Huberman Lab podcast. They discuss how the pandemic sparked a consumer health revolution, the emerging peptide and GLP landscape, what the science actually says about focus drugs, and the neurotechnologies Huberman believes will let us write to our own biology within the next five years.   Resources: Follow Andrew Huberman on X: https://twitter.com/hubermanlab Follow Daisy Wolf on X: https://twitter.com/daisydwolf Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to the a16z Show on Apple PodcastsFollow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

You can't watch a single sporting event without being hit with an Ozempic commercial — but did you know that those GLP-1s everyone's talking about are actually peptides? Kyal Van Der Leest — nutritionist, naturopath, and the formulator behind LvLUp Health — breaks down which peptides actually work, which ones are all hype, and why the Swiss Army knife of peptides (BPC-157) might be exactly what your gut, your joints, and your brain have been begging for. Kyal gets into the oral vs. injectable debate (Kyal sells oral peptides and still admits most oral ones don't work — gotta respect that), why your midlife body composition changes aren't just about willpower, the mould exposure conversation that'll make you side-eye your hotel room forever, and whether microdosing GLP-1s is the smarter play. If you're a Betty navigating perimenopause or menopause and want real, science-backed options beyond "just take Ozempic," this episode is your new best friend. Go to https://lvluphealth.com/DRSTEPHANIE and use code DRSTEPHANIE for 15% off. Episode Overview:0:00 Teaser/Intro6:30 Oral vs. Injectable Peptides11:22 The Cost, Convenience & Travel Factor15:47 BPC-157: The Swiss Army Knife of Peptides21:10 Arthritis, Autoimmunity & the Gut Connection27:28 GHK-Copper: Skin From Within & Longevity Genes35:54 Body Composition Changes in Perimenopause & Menopause43:24 Microdosing GLP-1s49:47 Mould: The Hidden Wrecker of Hormones, Gut & Brain58:49 How to Cycle Peptides (And Why You Should)1:02:38 Level Up Health: Where to Find These Products1:09:29 The After Party: Dr. Stephanie's Honest Take Resources mentioned in this episode can be found at https://drstephanieestima.com/podcasts/ep459 We couldn't do it without our sponsors: TIMELINE  - As perimenopausal women, we know we are in a fight against time to preserve our muscle strength and endurance, plus our recovery needs are greater. That's why you save 20% at https://timelinenutrition.com/better with code BETTER. JUST THRIVE HEALTH - Take the Just Thrive FEEL BETTER challenge today, and save 20% on your first order. Go to https://justthrivehealth.com/better and use the code BETTER to see the difference for yourself. BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. AGZ - If you're ready to turn down the stress and focus on the rest, head to https://drinkag1.com/STEPHANIE to get a FREE Frother with your first purchase of AGZ. EQUIP COLLAGEN - Support bones, joints, gut, and skin with Equip Collagen. Get 20% off at https://equipfoods.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of Anything But Average, Brittany and Christina dive into a very real conversation about health, healing, and the wake-up calls our bodies sometimes give us. Brittany shares the unexpected experience of landing in the hospital for an emergency appendectomy, walking through the symptoms, the fast-moving hospital visit, surgery, and what recovery has actually looked like in the days following. From the anxiety of not knowing what was happening to realizing how incredible the human body truly is, this experience became a powerful reminder about paying attention to the signals our bodies send. Christina also opens up about her own health journey right now, including ongoing back issues, exploring peptides, and the work required to maintain strength, mobility, and resilience. Together they unpack: • What happens when your body forces you to slow down • The importance of acting quickly when something feels off • Recovery, patience, and giving your body the time it needs • Exploring new tools and therapies that support healing • Why health awareness and self-care should never be optional   This conversation is honest, reflective, and a reminder that even the strongest, most driven people still need to listen to their bodies. Sometimes the biggest lesson is simply this: health is everything. About Brittany and Christina: Meet Brittany and Christina, your dynamic podcast hosts who bring their unique blend of expertise, passion, and life experience to every conversation. Brittany, affectionately known as Britt, mom, mommy, bruh, and Queen, lives in Vancouver with her husband and their three fantastic kids (tweens and teens, hence the playful nicknames). Together for nearly two decades, Brittany and her husband share a love for travel and adventure. A self-proclaimed endurance sport junkie, Brittany thrives on pushing herself beyond her comfort zone to unlock her full potential. As a coach, she specializes in helping clients overcome overwhelm by aligning personal goals and values with actionable steps for success. Her greatest joys come from connecting with new people and witnessing their incredible achievements. Christina Lecuyer, a former professional golfer and TV host, is recognized as one of GlobeNewswire's Top Confidence Coaches. She works with clients worldwide, including entrepreneurs, Wall Street executives, stay-at-home moms, and small business owners. Through her signature "Decision, Faith & Action" framework, Christina has guided thousands of clients in creating their own versions of fulfillment and success, often leading to thriving six- and seven-figure businesses. Her 1-on-1 coaching model focuses on mindset and strategy to build self-trust, confidence, and long-term results. Together, Brittany and Christina bring their authentic, energetic, and empowering perspectives to help listeners navigate life, achieve their goals, and embrace their fullest potential.   Feeling like you want to share a hot topic you'd like us to discuss on the podcast? Send us a DM over on Instagram at @anythingbutaveragepod. Your hot topic just might make it in the next episode!

In this episode of the Flex Diet Podcast, I sit down with Dr. Ashley Dwyer, a PharmD-turned nutrition and fitness coach, to cover a wide range of topics, with a strong focus on PCOS (polycystic ovarian syndrome), a metabolic condition that affects fertility, cycles, and systemic health.  We dig into practical lifestyle strategies for insulin-resistant PCOS, including balanced meals, protein and fiber, blood sugar management, movement, and stress reduction, plus why long-term keto often isn't a great fit. We also discuss GLP-1 medications, including concerns about HRV and resting heart rate, and why foundations and coaching matter when someone uses them.  Finally, we discuss the current “wild west” of peptides, the lack of human data, dosing and purity issues, and the importance of transparency, consistency, and identity-based behavior change for body composition and long-term health. Sponsors: Flex4: Dr Ashley Dwyer's top 4 things for women to improve body composition: https://miketnelson.com/flex4 Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Check out: Real Coaches Summit 2026: https://realcoachessummit.com Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 05:02 Meet Dr Ashley 06:16 PCOS Explained 09:37 PCOS Nutrition Basics 11:31 Keto And Thyroid 15:21 Stress And Cardio 18:27 GLP1 Heart Effects 22:21 Maintenance And Habits 30:27 Identity And Mindset 32:56 Identity Reps and Habits 33:25 Daily Affirmations and Reminders 34:23 Taming Negative Self Talk 36:24 Peptides Hype and Risks 38:18 Anecdotes Dosing and Quality 42:38 Influencers Quick Fixes Foundations 43:56 Research Funding and Regulation 47:40 Transparency Natty vs Enhanced 49:55 Coaching Clients on Supplements 56:20 Outro Summit and Disclaimers Flex Diet Podcasts you may enjoy: Episode 359: Debunking Women's Fitness Myths with Dr. Lauren Colenso-Semple YouTube: https://www.youtube.com/watch?v=AG_iahp6t40 Episode 292: Expert Insights on Pelvic Floor Health, Stress Management & Functional Technique with Dr Catrina Fabian YouTube: https://www.youtube.com/watch?v=J3V3tCse-IA Connect with Dr Dwyer: Instagram: https://www.instagram.com/dr.dwyer Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

Today's conversation sits right at the edge of what many consider the next era of medicine — regenerative, precision-based, and centered on restoring function at the cellular level rather than simply managing symptoms.To guide us through this rapidly evolving field, I'm joined by Dr. Jeff Gross. Dr. Gross is a spine fellowship-trained neurological surgeon, an internationally recognized speaker in regenerative and biohacking medicine, and the founder of ReCELLebrate. With a background spanning biochemistry at UC Berkeley to a medical degree from George Washington University, he has spent years working at the intersection of surgical medicine, stem cell science, and cutting-edge biologics.We're diving into exosomes — tiny extracellular vesicles that act as biological messengers, carrying proteins, lipids, RNA, and signaling molecules between cells. Once dismissed as cellular debris, exosomes are now recognized as key regulators of inflammation, tissue repair, immune modulation, and possibly even aging itself. In other words, they don't just participate in healing — they help coordinate it.In this episode, we explore how exosomes differ from stem cells, what the current evidence actually shows, where they're being used clinically — from sports injury recovery to chronic inflammatory conditions — and what their role may be in extending health span, not just lifespan. We also discuss safety considerations, dosing questions, regulatory realities, and the future trajectory of regenerative therapeutics as patient demand for non-pharmaceutical solutions continues to grow.If you're a clinician, a biohacker, or simply someone interested in where medicine is heading over the next decade, this is a conversation you don't want to miss.

Check Out BioVitalis Peptides: https://biovitalis.org/ (Use Promo Code: GSD10 for 10% off)   Check Out ZONE (Amazing Nootropic for Mental Focus and Energy): https://forjlife.com/products/zone-nootropic-supplement-mental-focus-eye-fatigue   *Disclaimer: This NOT medical advice. Please make sure to seek your own medical professional for medical advice.

Potentially the most outspoken man in the bodybuilding industry.APR Health Solutions: www.aprhealthsolutions.comOptimize HRT Clinic: https://members.optimize-hp.com - code 'NYLE'Merch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle00:00:00 Intro00:03:22 Catching Up with Phil Viz00:05:32 Advanced Follicle Bio-Hacking00:12:06 The Peptide Gut Protocol00:15:30 The Truth About Kratom00:17:55 Pushing Mitochondrial Limits00:20:14 Microdosing Insulin & GLP-1s00:23:45 Warning: The Motility Crisis00:28:41 Mechanical Gut Scraping00:33:02 Sourcing Laboratory Standards00:37:30 Mentorship & Origin Stories00:45:00 Execution Under Fire00:48:10 Victory Has Defeated You00:51:30 Psychological Pain as Fuel00:53:30 Evolution of the Hard-Ass00:57:01 Logic Over Depression01:00:30 The Insulin Sensitivity Debate01:02:24 The False Positive GH Myth01:05:00 Hyperplasia & Skin Quality01:13:02 The Rebuild Blueprint01:18:15 Metrics of Longevity01:21:43 Pharmacological Resilience01:28:13 The Solidification Phase01:31:30 Integrity of the Exit01:37:15 Firing Lagging Chains01:42:30 The Olympia Verdict01:46:27 Spinal Decompression Myth01:52:45 The Art of Mock Peaks01:58:07 Slamming the Rebound02:02:13 Morphing: Endo vs Meso02:15:24 Final Reflections on Empathy

Want a simple workout plan built for busy dads?Start here: Free 7-day Trial to my workout planRecover faster and hit your protein goals with Phormula-1 ProteinIn this episode of the Fit Fathers Podcast, host Ben Barker (Ben Barker Fitness) sits down with Adam Braud (@adambraud) for a real conversation about faith, fitness, and fatherhood.Adam is a lifelong martial artist and father who shares how following Jesus, training Jiu-Jitsu, and prioritizing health have shaped the way he leads his family and lives with discipline.This episode goes deep into topics many dads are curious about but rarely hear discussed honestly—from peptides and TRT, to nutrition strategies for busy fathers, to the simple exercises every dad should master to stay strong for life.Whether you're trying to get stronger, lead your family better, or build a body that can keep up with your kids, this conversation will give you practical takeaways you can apply immediately.In this episode we cover:• How faith in Jesus shapes discipline, purpose, and leadership as a dad• Why Jiu-Jitsu is one of the best activities for fathers• Honest thoughts on TRT and peptides in today's fitness world• Simple nutrition strategies for busy dads• Adam's Top 5 exercises every dad should be doing• How to build strength that actually translates to real lifeIf you're a dad who cares about faith, family, and fitness, this episode is for you.Subscribe to the Fit Fathers Podcast for weekly conversations helping dads get stronger in faith, fitness, family, and finances.

MAHA News is back with a packed Friday show covering the latest developments in health policy, technology, and transparency. The hosts kick things off by discussing a proposed New York bill that would restrict AI chatbots from offering medical or legal advice, raising questions about whether powerful industries are trying to slow the disruption AI is bringing to healthcare and professional services. They also examine a new MIT study suggesting heavy reliance on AI tools may weaken critical thinking and memory retention. From there, the conversation shifts to Robert F. Kennedy Jr.'s push for greater accountability in the food industry, including calls for Dunkin' and Starbucks to release safety data on high sugar drinks. The show also highlights a new initiative requiring medical students at dozens of schools to complete nutrition training before graduation, a step toward addressing chronic disease through better education. Later in the episode, the hosts break down major declassification claims from Dr. Robert Malone linking historical U.S. military experiments to the spread of Lyme disease. They also discuss newly announced peptide policy changes, debates over glyphosate lawsuits, and continued scrutiny of vaccine messaging from federal health agencies.

Let us know what you think!Sheen Mayberry shares his journey from military service to politics and nonprofit leadership. This episode explores personal growth, leadership, and why veterans must step forward to shape the future.In This Episode:• Military transition and growth • Veterans in politics • Leadership lessons • Political system realities • Community and purpose

Send a textToday I'm joined by Dr. Ashley Dwyer, PharmD, a pharmacist who brings a refreshingly practical voice to the world of health and wellness. With all the buzz right now around peptides, biohacking, and supplement stacks, it can feel like you need a cabinet full of products just to stay healthy.In this conversation, Dr. Dwyer explains what peptides actually are, why she's cautious about over-recommending supplements, and why the fundamentals still matter most.We also talk about something powerful, building an identity as a fit and healthy person, and how that mindset is often the real key to long-term, sustainable health.Let's get into my conversation with Dr. Ashley Dwyer!Follow AshleyJoin Move Daily MembershipFOLLOW ALONG with Move Daily Fitness!Follow on InstagramFollow on FacebookIndemnity** All information provided by Move Daily Fitness and Tracy Steen is of a general nature and is furnished for educational/entertainment purposes only. No information is to be taken as medical or other health advice pertaining to any individual's specific health conditions. Move Daily is not engaged in rendering any medical services. Move Daily makes no guarantee regarding the accuracy, timeliness or relevance of any text, video or audio content. Any content provided is not a diagnosis, treatment plan or recommendation for a particular course of action regarding your health and it is not intended to provide specific medical advice. Do not delay in seeking the advice and diagnosis of a medical professional because of anything you may have read or interpreted from Move Daily Fitness content.  Consult your health care professional before participating in or acting on any recommendations found on Move Daily Fitness.  You agree, at your exposure, to indemnify and hold Move Daily Fitness and Tracy Steen harmless from any and all losses, liabilities and injuries, or damages resulting from and all claims, cause of action, suits, proceedings and demands against Move Daily Fitness and Tracy Steen, arising from or relateGrab our new How To Build Muscle As You Age 4.0 (Beginner or advanced avilable) The Move Daily Membership is a paid monthly subscription for women, which gives you access to a huge amount of resources to help support you in reaching your health goals. Whether you're looking to lose fat, gain lean muscle, focus on your nutrition, give time to wellness or simply wish to dial in your overall health, we can support you in achieving your objectives. Join today! Shop Legion Supplements and use discount code: MoveDailyThis is an affiliate link.Support the showUse discount code PODCAST10 for a discount on your Move Daily Membership. Don't fade out women, level up! Thanks for moving daily with us in your fitness, wellness and nutrition! Be sure to follow us here:YouTubeInstagramFacebookTikTokSubscribe to my podcast!

Links to All Articles Mentioned:https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-riskshttps://www.fda.gov/media/174456/downloadRFK Jr. just appeared on the Joe Rogan podcast and peptides were front and center. Dr. Matt Kaeberlein breaks down the conversation in real time, fact-checking claims about peptide efficacy, FDA regulation, and the growing black market for compounded peptides.What does the science actually say? What did RFK get right and where did the conversation miss the mark? Dr. Kaeberlein cuts through the noise with a scientist's lens, covering everything from BPC-157 to GLP-1 agonists to the FDA's Category 2 bulk drug substances list.If you're navigating the peptide space and want clarity over hype, this one's for you.Timestamps:00:00 — Intro & Episode Overview01:06 — RFK on Joe Rogan: The Peptide Conversation Begins02:06 — First Fact Check: "We Know Peptides Work"03:50 — GLP-1 Agonists: The Exception, Not the Rule05:05 — RFK's Personal Peptide Experience06:32 — The FDA's Bulk Drug Substances List Explained08:32 — FDA Category 2: What It Actually Means09:21 — The Peptides That Were Banned From Compounding10:18 — Did the FDA Consider Safety? Here's What the Data Says12:03 — Real Cases of People Harmed by Compounded Peptides13:40 — Can the FDA Consider Efficacy? Reading Directly From the Guidelines15:44 — The Peptide Black Market: How It Emerged17:54 — Will Reversing the Ban Actually Fix the Problem?19:20 — RFK's Push to Move 14 Peptides Back to the Bulk List20:16 — Dr. Kaeberlein's Take: Informed Patient Access Matters21:51 — Who Created the Black Market?22:46 — What Would Actually Help: Funding Real Clinical Trials23:36 — Final Thoughts & Call to Action

Let me know if you like this type of "solo podcast" and what you'd like to hear next! I'm happy to make anything you guys would like - update on my training and goals since hanging up the towel on competing, recap of my last prep and show season, my current diet, full day of eating, post-bodybuilding drug stuck, peptides - anything! Thank you!    https://www.instagram.com/scott_mys/   Use code "ScottM" at www.BiolongevityLabs.com to save on all Peptides for fat loss, tissue healing, and much more! Get the best prices on quality, lab-tested peptides and help support the show.   This podcast is brought to you by LMNT Electrolytes! It's great for a hot summer day, a workout, or just working at your desk with cold water. Check it out and get your free sample pack along with any regular purchase when you use my custom link, www.drinklmnt.com/ScottMys. The LMNT Sample Pack includes one packet of their most popular flavors. This is the perfect offer for 1) anyone who is interested in trying all of our flavors or 2) anyone who wants to introduce a friend to LMNT. Go to www.drinklmnt.com/ScottMys to claim this awesome deal!   Interested in working with me 1-1? DM me on Instagram and I can answer any questions. If you like, we can even set up a FREE consult call to go over your goals, answer questions, and discuss what it could look like to work together!   Disclaimer: The views presented on this show are not to be taken as medical advice. Please consult your doctor before adopting a new diet or nutrition regime.

In this episode of the Future of Fitness Podcast, host Eric Malzone sits down with Chris Mirabile, founder of NOVOS, to unpack the science and business of longevity. Chris shares how surviving a brain tumor as a teenager reshaped his perspective on health and pushed him to study aging at a biological level. The conversation dives into what longevity actually means beyond buzzwords—how it differs from simply living a healthy lifestyle, why healthspan matters just as much as lifespan, and the science behind targeting the biological "hallmarks of aging." Chris also explains why some popular trends like hormone optimization and peptides are more complex than they seem, and how NOVOS approaches longevity by addressing the root cellular mechanisms that drive aging, disease risk, and long-term performance. Key Takeaways:

Let us know what you think!In this solo episode of Security Halt! Podcast, host Deny Caballero breaks down Warrior Rising's new Activate Program, an eight-week startup accelerator created in partnership with Virginia Tech's Boeing Center for Veterans Transition and Military Families.Designed for veterans and military spouses building tech startups, the Activate program focuses on testing, validating, and launching new companies with mentorship, resources, and community support.Deny explains why entrepreneurship is becoming a powerful next mission for veterans transitioning out of service—and how programs like Activate provide the structure and guidance needed to succeed.Chapters:00:00 The Entrepreneurial Journey After Military Service 03:00 Warrior Rising's Mission Supporting Veteran Entrepreneurs 04:22 The Activate Program and Startup Accelerator Explained 07:50 Entrepreneurship as the Next Mission for VeteransActivate Program sign up: https://forms.monday.com/forms/e4127d9884803c09496356dd5fa28100?r=use1Warrior Rising Website: https://warriorrising.org/Instagram: https://www.instagram.com/wearewarriorrising/Facebook: https://www.facebook.com/WeAreWarriorRising/Sponsored by: Dr. Mark Gordon & Millennium Health Centers  Get the book Peptides for Health Vol.1 Medical Edition today.  Use code PTH25 for 25% off through March 15  Use code Phase2P for 10% off Millennium products  Available only at MillenniumHealthStore.comPure Liberty LabsUse code: Security_Halt_10Website: https://purelibertylabs.com/ PRECISION WELLNESS GROUP Use code: Security Halt Podcast 25Website: https://www.precisionwellnessgroup.com/  Security Halt Mediahttps://www.securityhaltmedia.com/ Instagram: @securityhaltX: @SecurityHaltTik Tok: @security.halt.podLinkedIn: Deny CaballeroSupport the showProduced by Security Halt Media

Watch Here : https://www.youtube.com/watch?v=XXY-0sxofNQ Website: https://vigoroussteve.com/ Consultations: https://vigoroussteve.com/consultations/ eBooks: https://vigoroussteve.com/shop/ YouTube Channel: http://www.youtube.com/user/VigorousSteve/ Workout Clips Channel: https://www.youtube.com/channel/UCWi2zZJwmQ6Mqg92FW2JbiA Instagram: https://instagram.com/vigoroussteve/ TikTok: https://www.tiktok.com/@vigoroussteve Reddit: https://www.reddit.com/r/VigorousSteve/ PodBean: https://vigoroussteve.podbean.com/ Spotify: https://open.spotify.com/show/2wR0XWY00qLq9K7tlvJ000 Patreon: https://www.patreon.com/vigoroussteve

See exclusives at https://SarahWestall.Substack.comPolitical analyst Dave Hodges rejoins the program to discuss his findings linking Attorney General Pam Bondi and FBI Director Kash Patel to the Epstein scandal. His revelations have been missed, unsurprisingly, by the mainstream media and represent what he argues is a serious conflict of interest related to the Epstein case.In this conversation, Dave walks through the connections he uncovered, why he believes they matter, and how they could affect the broader understanding of the Epstein network and the unanswered questions surrounding it.We also discuss Turning Point USA (TPUSA) and the continual stream of scandals related to the operation of the organization, including the controversy and questions surrounding the reported death of Charlie Kirk.You can follow Dave Hodges at https://TheCommonSenseShow.comLinks and Offers Mentioned in the show:Buy quality at Quince.com/BusinessGame - get free shipping and 365-day returns! Now available in Canada too!Buy Anti AgingMUST Sign up as a VIP to see certain peptides like Retatrutide at https://limitlesslifenootropics.com/vip-club-registration/?uid=116&oid=1&affid=10134Buy Exercise Mimicking & Muscle Building Peptide SLU-PP-332 at https://www.limitlesslifenootropics.com/product/slu-pp-332-250mcg-60-capsules/?ref=vbWRE3J
- Use code Sarah to save 15%Purchase the most effective weight peptide available, Next Generation GLP-1 Retatrutide - use code Sarah to save 15%: https://www.limitlesslifenootropics.com/product/retatrutide-ha/?ref=vbWRE3JSee the Peptide stack for weight loss stack in the Ultimate Peptide Guide for Weight Loss and Muscle Preservation at https://sarahwestall.substack.com/p/the-ultimate-peptide-guide-for-weightCopyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
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In this episode, Dana sits down with Dr. Sofia Din — physician, longevity specialist, and author of Do We Really Need Botox? — for a powerful conversation about beauty, aging, hormones, and the future of wellness medicine. Dr. Din shares her journey from practicing traditional medicine to focusing on preventative health, longevity, and menopause care, explaining why so many women feel disconnected from their bodies as they age — and what we can do about it.    They dive deep into topics like: • Why menopause affects every system in the body • The truth about beauty and genetics • Hormone replacement therapy and the mistakes medicine made • IV infusions, vitamins, and bioavailability • Peptides and the future of anti-aging medicine • GLP-1 medications and metabolic health • How women can protect their vitality and longevity   This conversation explores the intersection of science, beauty, and longevity, and why the future of medicine is shifting from sickness management to helping people stay vibrant, healthy, and energized for longer. If you're interested in hormone health, anti-aging science, peptides, IV therapy, and longevity medicine, this episode is packed with insights. Subscribe for more conversations on women's health, longevity, hormones, and wellness innovation.  

How do peptides, collagen, and adaptogens actually support radiant skin? Why do so many people fail to see results from supplements and skincare? In this episode, we explore the internal tools that support skin health from the inside out including peptides, collagen, adaptogens, protein, and creatine. I also share practical strategies to help you support your skin through nutrition, recovery, stress management, and smart supplementation and common mistakes that prevent many people from seeing results.Shop my skincare products to keep your skin looking radiant this season: https://alwaysradiantskinshop.com/Step into your Radiance Sanctuary in the Membership https://www.theschoolofradiance.com/membershipFor more resources related to today's episode, click here for the podcast episode page: https://www.theschoolofradiance.com/podcasts Follow Rachel Varga Official on Instagram: https://www.instagram.com/rachelvargaofficial/ —Catch full episodes of The School of Radiance Podcast here on YouTube https://www.youtube.com/@RachelVargaOfficial —Subscribe to the YouTube channel here: https://www.youtube.com/@RachelVargaOfficial —Follow me here:Instagram: https://www.instagram.com/rachelvargaofficial/ Facebook: https://www.instagram.com/rachelvargaofficial/ Website: https://www.theschoolofradiance.com —FREE STUFF: Download my FREE Skincare Checklist, sign up for my FREE 30 minute biohack your way to clear skin and slowing aging training now, and my newsletter for promos and exclusive events just for you! https://www.theschoolofradiance.com/freebiesEveryone gets one FREE call! Book your free 15-minute call with Rachel Varga to see which options will help you achieve your skin radiance goals! https://rachelvarga.as.me/YourPersonalizedRadianceConsultation —Looking for Skincare products, Tutorials, booking YOUR private One-on-One, and the deep dive Radiance Membership?SHOP skincare: https://alwaysradiantskinshop.comBOOK your private One-on-One: https://rachelvarga.as.me/Initialconsultation REGISTER for Tutorials and/or Membership: https://theschoolofradiance.com As a disclaimer, please note that the information shared in this podcast and interview is not to be taken as medical advice, and it's always important to consult with your physician before making any lifestyle changes. Rachel disclaims any responsibility for inaccurate credentials of guests or information used that may cause harm.Thank you for tuning in to this episode of The School of Radiance with Rachel Varga (formerly The Rachel Varga Podcast and The Always Radiant Skin Podcast)!Rachel Vargainfo@theschoolofradiance.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Let us know what you think!Geoff Dardia shares his journey through toxic exposures, mental health struggles, and recovery. This episode exposes Operator Syndrome and highlights the importance of proactive healthcare and community support.In This Episode:• Operator Syndrome explained • Toxic exposures and medications • Veteran recovery and mental health • Task Force Dagger's mission • Family and community support

The legal landscape for peptide therapy is changing. In this episode, Dr. Greg Jones talks with healthcare attorney Jeff Cohen about recent regulatory updates and their implications for providers. Jeff explains the risks of using "Research Use Only" products in a clinical setting and how to properly verify your suppliers' quality and safety. You will learn why it is important to focus on education rather than promotion on your website and how to improve your informed consent process to protect your license. Jeff also discusses the goals of the new American Peptide Association in setting industry standards. This conversation provides clear steps for clinic owners and practitioners to stay compliant while using compounded medications.

On This Episode Of RawTalk, Bradley Martyn Sits Down With Chicos Toxicos And Talks Felipe Getting Called Out in Church, Launching Their New Drink, Diego Surprising Felipe with a Brand New G35, Brad's Prime Protein Partnership, Peptides, Black Holes & So Much More!Sponsored by: Morgan & MorganHttps://www.forthepeople.com/rawtalk Sponsor RAWTALK: https://public.liveread.io/media-kit/rawtalkSUBSCRIBE HERE: https://www.youtube.com/c/REALRAWTALK?sub_confirmation=1LISTEN ON APPLE PODCASTS: https://podcasts.apple.com/us/podcast/rawtalk/id1294154339FOLLOW RAWTALK PODCAST:INSTAGRAM | https://instagram.com/getrawtalkTIKTOK | https://tiktok.com/@askrawtalkFOLLOW BRADLEY:INSTAGRAM | https://instagram.com/bradleymartynSUBSCRIBE TO RAWTALK PODCAST CLIPS: https://www.youtube.com/channel/UCvzSBNBOK599FqzrTZS8ScQ/?sub_confirmation=1SUBSCRIBE TO LIFE OF BRADLEY MARTYN: https://www.youtube.com/channel/UCWTQG2aMDYKGDqYEGqJb1FA/?sub_confirmation=1SUBSCRIBE TO FITNESS CHANNEL: https://www.youtube.com/bradleymartynonline?sub_confirmation=1RAWGEAR: https://www.rawgear.com (CODE:RAW)

What if aging isn't an inevitability but a system you can learn to influence? We sit down with Jay Campbell, author, founder of Bio Longevity Labs, and longtime voice in hormone optimization, to pull back the curtain on peptides, GLP-1s, TRT, and the habits that actually move the needle on biological age. No fluff, no hype cycles, just a direct path through the noise so you can stop guessing and start compounding wins.Jay explains why only a sliver of people truly understand peptides, how GLP-1s can slash obesity risk when used with intention, and why most failures come from bad sourcing and worse guidance. We cover the core stack of real-world results: protein-forward nutrition, intelligent strength training, daily movement, high-quality sleep, and targeted therapeutics. If you've felt stuck between social media extremes, miracle claims on one side, fatalistic “it is what it is” on the other, this conversation gives you the signal you've been missing.We also tackle the stigma around testosterone replacement therapy and the sports-era myths that still scare people away from safe, supervised care. Jay breaks down how to vet vendors, avoid counterfeit peptides, and recognize when AI-fed summaries are confidently wrong. Along the way, we talk recovery gains after 40, the danger of chasing the cheapest vial, and why mindset is the master lever: your thoughts shape your routines, and your routines sculpt your biomarkers.If you're ready to trade shortcuts for strategy and turn back metabolic drift with data and discipline, this is your playbook. Press play, take notes, and then take action. If this resonates, share it with someone who needs a nudge, subscribe for more contrarian health truth, and leave a review to help others find the show. Your future self will thank you.Join the What if it Did Work movement on FacebookGet the Book!www.omarmedrano.comwww.calendly.com/omarmedrano/15min

Text us a comment or question!What if up to 40% of dementia cases could be prevented — not with drugs, but with daily lifestyle choices?In this powerful episode of The Over 50 Health & Wellness Show, I sit down with molecular biologist and AI health innovator Thoryn Stephens, Founder & CEO of BRAIN.ONE, to unpack the real science behind brain health, longevity, and sustainable optimization after 50.We go beyond hype and dig into what actually moves the needle when it comes to protecting your cognition, extending your health span, and building a strong, capable body and mind for decades to come.In This Episode, We Cover:1. The Lifestyle Levers That Could Prevent 30–40% of DementiaBased on emerging global research, including insights from The Lancet 2024, we discuss:Why nutrition is foundational for brain healthThe role of strength training and physical activityHow sleep impacts cognitive declineWhy stress and social isolation matter more than you thinkThe surprising impact of hearing and vision health2. The #1 Longevity Hack (Hint: It's Not a Supplement)If you're looking for the single most powerful lever for brain health, Thoryn says it's this: Sleep.We discuss:Why sleep deprivation accelerates agingHow alcohol affects heart rate variability (HRV) and recoveryWhy measuring your sleep can change your behaviorHow to optimize without becoming obsessive 3. Measure What Matters: Wearables & Health Tracking After 50“You can't manage what you don't measure.”We break down:How wearables like Garmin, Oura, and Apple Watch can guide behaviorWhat HRV actually tells youHow small data insights lead to big long-term changesThe danger of letting data run your life 4. Peptides, GLP-1s & The Wild West of Longevity MedicinePeptides are everywhere right now. But are they miracle solutions — or risky trends?We cover:What peptides actually areThe difference between research and prescription peptidesMicrodosing GLP-1s and what it meansThe regulatory gray zoneWhy most doctors aren't trained in this space 5. AI, Brain Optimization & The Future of HealthWe explore:How AI is being used in brain-computer interfacesThe potential (and risks) of uploading health data to AI platformsWhat “Mindspan” means — and why it mattersWhy the future of health is hyper-personalizedBut here's the twist…Despite all the high-tech innovation, Thoryn keeps coming back to the basics. 

Cameron is joined by Dr. Rahi, a double board-certified specialist in integrated wellness and aesthetics, and they discuss her journey from Iran to Beverly Hills and her practice's evolution since 2017. She emphasizes the importance of integrating wellness with esthetics, using comprehensive patient intakes and personalized treatments. She provides insights into advanced therapies like peptides and GLP-1s. She highlights the role of social media, particularly Instagram, in marketing her practice, along with word-of-mouth referrals. She also discusses the rapid advancements in peptide therapy and other regenerative treatments, stressing the need for proper medical oversight. Dr. Rahi advises aspiring entrepreneurs to embrace change, maintain confidence, and prioritize self-care.Listen In!Thank you for listening to this episode of Medical Millionaire!Takeaways:Integrate esthetics with preventive wellness careComprehensive intakes beyond basic cosmetic concernsOrganic social media drives patient growthWord-of-mouth remains most powerful marketingAdvanced therapies: peptides, GLP‑1s, exosomes risingMedical oversight crucial for peptide safetyShift from overfilling to regenerative treatmentsProvider must embody optimized health personallyPractice evolves yearly; embrace constant changeFailures normal; keep adjusting and movingImmigrant journey built resilience and gritStrong self-belief essential for entrepreneurshipMedical Millionaire: The Blueprint for Scaling a World-Class Medical Aesthetics PracticeWelcome to Medical Millionaire, the go-to podcast for forward-thinking Medspa owners, Medical Aesthetics leaders, Plastic Surgery & Dermatology practices, Concierge Wellness clinics, and Elective Healthcare entrepreneurs who are ready to scale with intention and operate like a true, high-performing business.If you're building, growing, optimizing, or preparing to exit your aesthetics or wellness practice, this show is your competitive advantage.Hosted by Cameron Hemphill Your Guide to Sustainable, Scalable Growth Your host, Cameron Hemphill, is one of the most trusted growth strategists in Medical Aesthetics and Elective Wellness.With over 10 years in the industry, Cameron has helped scale 1,000+ practices and more than 2,300 providers, working alongside the most recognized KOLs, national brands, EMRs, tech companies, and private equity groups, shaping the future of aesthetics. From marketing to operations, from finance to leadership, Cameron brings a real-world, data-driven perspective on what it takes to turn a practice into a powerful business engine.What This Podcast Is All About: Each episode takes you behind the scenes of the fastest-growing practices in the country, revealing the systems, strategies, and mindset required to win in today's Medical Aesthetics landscape.Expect tactical insights, step-by-step frameworks, and conversations with:Industry thought leadersTop injectors & medical directorsEMR & tech innovatorsOperations expertsMarketing strategistsPrivate equity & M&A advisorsWellness and longevity pioneersThis is where aesthetics, business, technology, and wellness converge. What You'll Learn on Medical Millionaire Every week, you'll access expert guidance to help you scale profitably and predictably, including:Marketing & Brand PositioningCRM + Lead Management SystemsPatient Acquisition & ConversionEMR Optimization & Tech Stack ArchitectureSales Psychology & Consultation MasteryFinance, KPIs, and Practice EconomicsOperational Workflows & AutomationIndustry Trends Backed by Real Benchmark DataPatient Retention & Lifetime Value ExpansionMindset, Leadership & Team DevelopmentWhether you're opening your first location or running a multi-million-dollar enterprise, you'll gain the clarity and direction to grow with confidence. A Show Designed for Every Stage of Practice Growth Medical Millionaire breaks down the journey into four essential stages, showing you exactly how to move from one to the next:Startup – Build the foundation and attract your first wave of patientsGrowth – Scale revenue, expand services, and strengthen operationsOptimize – Increase efficiency, margins, and customer experienceExit – Prepare your practice for maximum valuation and acquisitionIf You're Ready to Grow, This Is Where You Start. Tune in weekly for actionable insights, expert interviews, and the exact playbooks high-performing practices use to dominate their markets. This is the podcast for Medspa owners who want more than a job; they want a scalable, profitable, industry-leading business. Welcome to Medical Millionaire.Let's build your practice into the empire it deserves to be.

In this episode of Creating Your Ageless Future (Health Accelerator Challenge), Regan Archibald uses a “peptides as information” framework to discuss how peptides fit into the broader landscape of modern health and wellness. He contrasts how pharmaceuticals are typically defined and evaluated (including the clinical trial pathway) with the way he thinks about peptides as signaling molecules that interact with receptors and influence cellular communication. Along the way, he shares analogies (like texting vs. phone calls) to explain why context—such as lifestyle factors and individual variability—matters when people talk about outcomes, and he cautions against DIY protocols and unreliable sourcing. He closes by encouraging education, responsible oversight, and participation in upcoming community events.RESOURCES:Book Comprehensive Labs: https://agelessfuture.com/longevity-labs/FREE copy of The Peptide Blueprint: https://agelessfuture.com/blueprintSign up for future Health Accelerator Challenges calls LIVE! https://us02web.zoom.us/webinar/register/WN_YZsiUMOzSyqcE8IinC5YEQ#/registrationBooks: https://www.amazon.com/Books-Regan-Archibald/s?rh=n%3A283155%2Cp_27%3ARegan%2BArchibaldArticles: https://medium.com/search?q=Regan+ArchibaldLIKE/FOLLOW/SUBSCRIBE:YouTube -https://www.youtube.com/@ReganArchibald / https://www.youtube.com/@Ageless.FutureLinkedIn: https://www.linkedin.com/in/regan-archibald-ab70b813Instagram: https://www.instagram.com/ageless.future/Facebook: https://www.facebook.com/AgelessFutureHealth/DISCLAIMER: This video is for educational purposes only and does not provide medical advice, diagnosis, or treatment.  Many of the molecules discussed in this video are research compounds and are not approved by the U.S. Food and Drug Administration (FDA) for any specific medical use, indication, or condition. They are mentioned only in the context of existing scientific literature and ongoing research and are not being recommended, prescribed, sold, or offered through this video.  This content does not endorse or recommend any specific tests, products, procedures, or treatment protocols.References to our clinic are for general educational context only; investigational or non‑approved products are not available for direct ordering or prescribing based solely on viewing this content.  Do not start, stop, or change any medication, peptide, or supplement based on this video. All medical decisions must be made with a licensed prescribing clinician after a proper evaluation. No provider–patient relationship is created by viewing this content or contacting our clinic.  Regan Archibald is a Licensed Acupuncturist and longevity coach. He is not a medical doctor. Cade Archibald is COO and Co-Founder of Ageless Future, also not a medical doctor. All medical decisions, lab ordering, and prescribing in our clinic are performed only by our licensed medical team (MD, APRN, PA).  Viewers should follow the guidance of their own licensed clinicians and local health authorities regarding diagnosis and treatment decisions.

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice. Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise. This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology. You'll Learn: Why precision medicine outperforms population-based health strategies for human performance How to layer genomics, transcriptomics, and proteomics into one complete biological picture Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits The real story on metformin, peptides, and which supplements actually move the needle How AI can help you understand your own biology and act on it faster Why biohacking precision beats random stacking every time Thank you to our sponsors! • Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order. • BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com • Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs Resources: • Learn More About Anil's Work And the Institute For Human Optimization At: https://ifho.org/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:53 – Intro to Precision Medicine 01:58 – Dr. Bajnath's Holistic Health Journey 05:03 – Pharmaceuticals vs. Supplements 07:58 – Peptides and Longevity Molecules 10:34 – Sexual Health and Vitality 13:56 – Vascular Health and Blood Flow 15:14 – Multi-Omics Approach 19:03 – DNA and Genomics 22:17 – Transcriptomics and RNA 24:24 – Proteomics and Inflammation Markers 32:00 – The Human Exposome 34:55 – Key Health Biomarkers 36:58 – Cell Membrane Dynamics 40:28 – Biological Investment Strategy 41:53 – Life Extension Possibilities 48:52 – Bioenergetics and Mitochondria 49:47 – Quantum Medicine and the Future 51:33 – Vagal Nerve Stimulation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

President Trump's military strike on Iran is sending shockwaves through the globe — and the media meltdown is in full swing.In this episode, we break down Trump's response to Iran, whether this is the start of another “endless war,” and what Defense Secretary Pete Hegseth had to say about boots on the ground. Secretary of State Marco Rubio sets the media straight, while critics on the right — including Matt Walsh, Tucker Carlson, and Megyn Kelly — question the strategy. Trump fires back.We also revisit Hillary Clinton's past comments about “obliterating” Iran, the Clinton deposition drama involving Bill Clinton, and the Epstein fallout that Republicans may have fumbled.International reaction pours in from NATO Secretary General Mark Rutte, while tensions rise between the U.S., Iran, and Israel — with Israeli Prime Minister Benjamin Netanyahu weighing in.Plus:- A shocking UN condemnation- Viral TikTok reactions- Influencers flip-flopping- A heated moment on The View- Latest Gen Z slangSUPPORT OUR SPONSORS TO SUPPORT OUR SHOW!Unlock healthier skin by targeting visible aging signs with OneSkin's OS-01 Peptide at https://OneSkin.co/CHICKS using code CHICKS for 15% off.Schedule your FREE risk review from Bulwark Capital at https://KnowYourRiskPodcast.comBackyard Butchers: Lock in under $10/meal while beef prices climb at https://BackyardButchers.com/Chicks  Code CHICKS auto-applies for 30% off first order + 2 free 10-oz ribeyes + free shipping!Subscribe and stay tuned for new episodes every weekday!Follow us here for more daily clips, updates, and commentary:YoutubeFacebookInstagramTikTokXLocalsMore InfoWebsite

On today's episode, I'm joined by celebrity esthetician Mimi Luzon — known for working with supermodels like Irina Shayk — for a deep dive into what actually works in skincare. We break down the truth about peptides and exosomes, how to choose high-quality ingredients, and which treatments truly improve skin elasticity and tighten from within. Mimi shares her thoughts on popular technologies like radio frequency, microneedling, Morpheus8, EMS, and lasers — plus the treatments she recommends avoiding. We also discuss how to build the right skincare routine in your 20s, 30s, and 40s, the biggest mistakes people make with acne and exfoliation, how to treat melasma and rosacea, and why SPF, sleep, and nutrition are non-negotiables for glowing skin. If you want clearer, tighter, healthier skin — and a smarter strategy behind your routine — this episode is packed with practical, expert-backed insights. Enjoy!To connect with Siff on Instagram, click HERE.To connect with Siff on Tiktok, click HERE.To learn more about Arrae, click HERE. To check out Siff's LTK, click HERE.To check out Siff's Amazon StoreFront, click HERE. To connect with Mimi on Instagram, click HERE.To shop Mimi Luzon on FWRD, click HERE. This episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Use code DREAMBIGGER15 for $15 off first purchase at thirdlove.comRedefine your standard of health. Secure 20% off your order and begin your intentional wellness journey today at Piquelife.com/dreambigger. That's Piquelife.com/dreambiggerThousands of guys have already used Rula to finally get the care they needed. Don't keep putting it off - go to Rula.com/dreambigger and get started today. Take the first step, get connected, and take control of your mental health.Get $25 off your first purchase when you go the TheRealReal.com/dreambiggerShopify.com/dreambiggerProduced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today's clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. In this quick hits episode you will hear a clip from my interview with Dr. Kirk Parsley — former Navy SEAL physician and one of the leading voices in sleep optimization — to unpack what chronic sleep deprivation is really doing to your body. Listen to the full episode here. Listen on Apple here. We dive into: Why Ambien and common sleep medications can damage long-term brain and hormonal health How chronic sleep loss mirrors traumatic brain injury How cortisol becomes your backup energy system when sleep fails Why poor sleep drives metabolic dysfunction and cravings How deep sleep regulates growth hormone, testosterone, estrogen, and stress hormones Why chronic insomnia is linked to shortened lifespan How poor sleep leads to beta-amyloid accumulation and neurodegeneration The connection between sleep loss, mitochondrial dysfunction, and menopause Why muscle health and mitochondria matter for brain resilience How peptides like Cerebrolysin, Dihexa, and BPC-157 may support neuroplasticity and inflammation reduction The emerging science of microdosing psychedelics for neurotrophic support and amygdala regulation Why melatonin production is disrupted by blue light and alcohol and MUCH MORE!     Sponsors Get 50% off the Energy Reboot Program hackmyage.com use coupon code HORMONES50.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

Most people obsess over lifespan—but what if the real metric that matters is healthspan? In this powerful conversation, Dr. JC Doornick sits down with world-renowned longevity expert Oz Garcia to unpack why so many people feel depleted, foggy, and biologically older than their years—even when their labs say they're “fine.” From post-COVID fatigue and chronic inflammation to mitochondrial health, cellular energy, brain vitality, and the responsible use of peptides as signaling molecules, this episode dives deep into what actually drives aging—and how to reverse the biological drift. If you've been asking, “Why am I always tired?” or wondering how to stay sharp, resilient, and fully alive after 40 or 50, this conversation will reframe everything you thought you knew about longevity. This isn't about hacks. It's about protecting your energy, preserving your brain, and staying in the game for decades to come. Connect with Oz Garcia: Website: www.ozgarcia.com IG - / @ozwellness   Dr. JC Doornick Links: Website - www.makessensebook.com YT -    / @drjcdoornick IG -   / @drjcdoornick FB -   / @makessensepodcast Makes Sense Book - https://tinyurl.com/makessensepurchase MAKES SENSE PODCAST Welcome to the Makes Sense with Dr. JC Doornick Podcast. This podcast explores topics that expand human consciousness and enhance performance. On the Makes Sense Podcast, we acknowledge that it's who you are that determines how well what you do works, and that perception is subjective and an acquired taste. When you change the way you look at things, the things you look at begin to change. Welcome to the uprising of the sleepwalking masses. Welcome to the Makes Sense with Dr. JC Doornick Podcast. SUBSCRIBE/RATE/REVIEW & SHARE our new podcast. FOLLOW Podcast: You will find a "Follow" button in the top right. This will enable the podcast software to alert you when a new episode launches each week. Apple: https://podcasts.apple.com/ca/podcast/makes-sense-with-dr-jc-doornick/id1730954168 Spotify: https://open.spotify.com/show/1WHfKWDDReMtrGFz4kkZs9?si=003780ca147c4aec Podcast Affiliates: Kwik Learning: Many people ask me where I get all these topics, which I've been covering for almost 15 years. I have learned to read nearly four times faster and retain information 10 times better with Kwik Learning. Learn how to learn and earn with Jim Kwik. Get his program at a special discount here: https://jimkwik.com/dragon OUR SPONSORS: Makes Sense Academy: A private mastermind and psychologically safe environment full of the Mindset and Action steps that will help you begin to thrive. The Makes Sense Academy. https://www.skool.com/makes-sense-academy/about The Sati Experience: A retreat designed for the married couple that truly loves one another, yet wants to take their love to that higher magical level. Relax, reestablish, and renew your love at the Sati Experience. https://www.satiexperience.com   0:00 - Intro 2:48 - What I like about Dr. OZ Garcia 5:57 - Lifespan vs. Healthspan? 8:25 - What's your position on the advancement of tech and lifespan 14:05 - The Better Educated Consumer of the Future 18:24 - Why do people feel biologically older while we are projecting a longer lifespan? 21:38 - Post Coved Chronic Inflammation and Fatigue 28:12 - What Causes Brain Fog - Is Cognitive Decline Reversible? 32:59 - Brain Optimization and Reducing Risk of Dementia and Alzheimer's 38:48 - What are the Top Three Most Essential Supplements to Take? 42:21 - What's the Buzz about Peptides, what are they, and why are they important? 47:33 - What is your take on GLP-1's and what is their correlation to longevity? 52:30 - What does Quality of Life Mean to You? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

March 3, 2026: Your daily rundown of health and wellness news, in under 5 minutes. Today's top stories: Temple raises $54M for temple-worn wearable continuously measuring brain blood flow to quantify focus, fatigue, and cognitive resilience in real time MyFitnessPal acquires AI-native Cal AI with $40M+ in sales, deepening push into digital nutrition tracking across 280M registered members HHS plans to reclassify 14 peptides including BPC-157 and CJC-1295 back to Category 1, enabling licensed compounding pharmacies to produce them with prescription More from Fitt: Fitt Insider breaks down the convergence of fitness, wellness, and healthcare — and what it means for business, culture, and capital. Subscribe to our newsletter → insider.fitt.co/subscribe Work with our recruiting firm → https://talent.fitt.co/ Follow us on Instagram → https://www.instagram.com/fittinsider/ Follow us on LinkedIn → linkedin.com/company/fittinsider Reach out → insider@fitt.co

What if your bloodwork is "normal"—but your health isn't optimized?     Lisa Fischer welcomes Regan Archibald back to explore how peptides are redefining longevity, metabolic health, and immune regulation. Instead of waiting for disease, Regan shares how comprehensive lab analysis can identify subtle imbalances in insulin, ferritin, thyroid antibodies, ApoB, and inflammatory markers—then match those findings with targeted peptide therapy.     They break down how peptides turn genes on and off, support muscle preservation, enhance neuroplasticity, improve sleep cycles, regulate stress hormones, and reduce systemic inflammation. The conversation also tackles safety, FDA regulation, compounding pharmacies, and why buying research peptides online can be risky. This episode is for anyone curious about epigenetics, advanced lab testing, and personalized health optimization beyond GLP-1 trends.     Link to the Little Rock Event: Link to event: https://agelessfuture.com/summit-26-03-20-little-rock/    

TTM Run Advanced is live. If improving your run times actually matters to you, this 16 week program is for you. Take 25% off with code RUN25. Sale ends Saturday, March 7 at midnight EST. Today's Overrated/Underrated Topics: 00:00:15 – Overrated/Underrated Intro 00:04:20 – California 00:09:04 – BPC 157 Peptides 00:11:22 – Carb cycling 00:16:04 – Push/Pull/Leg Split 00:20:17 – Zone 2 00:22:37 – Rice and Grinds as a main source of carbs 00:26:30 – Mobility and Stretching 00:31:02 – Voodoo's 5x5 00:35:41 – Leg blasters 00:38:26 – BJJ 00:41:03 – Running in kit 00:43:32 – Titan supplements 00:47:16 – Intuitive Rest Days 00:49:47 – Pre-workout 00:53:37 – Intervals on an assault bike/rower instead of running 00:55:37 – Icing for shin splints 01:00:21 – Prime Lifting Equipment 01:02:25 – Arsenal equipment 01:03:58 – Atlantis equipment 01:04:33 – Recovery Runs—Questions? Look for bi-weekly Q&A on my stories. I'll answer your questions on IG & on the podcast.—New Running Program: TTM Run AdvancedNew Selection Prep Program: Ruck | Run | Lift New Hybrid Program: Jacked Gazelle 3.0Ebook: SOF Selection Recovery & Nutrition Guide—TrainHeroic Team Subscription: T-850 Rebuilt (try a week for free!)—PDF programs2 & 5 Mile Run Program - run improvement program w/ strength workKickstart- beginner/garage gym friendlyTime Crunch- Workouts for those short on timeHypertrophy- intermediate/advancedJacked Gazelle- Hybrid athleteJacked Gazelle 2.0 - Hybrid athleteSFAS Prep- Special forces train-upRuck | Run | Lift - Selection Prep—Spoken Supplements: Code terminator_trainingCwench supplements: Code terminator_training—Let's connect:Newsletter Sign UpIG: terminator_trainingYoutube: Terminator Training Methodwebsite: terminatortraining.com

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Mazel morons! This week we welcome Dr. Craig Koniver (Josh's wellness wizard- not the Southern Charm star) to break down peptides, GLP-1s, methylene blue, muscle loss myths, and why half the internet is buying research-grade chemicals with “not for human use” on the label. Plus: bungalow discourse, Jewish kiddush engineering, microdosing Judaism, Botox myths, hair loss panic, and why Ben once accidentally did ketamine in a bathroom for 90 minutes. What are ya nuts?!Write in your questions to goodguyspodcast1@gmail.com!Follow us on Instagram and TikTok! Sponsors:Grab Goodwipes for free at Walmart so you can upgrade your restroom routine! Buy any one, two or three pack in Walmart or Walmart.com, text them your receipt, and get reimbursed almost immediately. For more details, head to goodwipes.com/GOODGUYS.Right now, Mizzen & Main is offering our listeners 20% off your first purchase at mizzenandmain.com, promo code goodguys20Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Caroline hosts renowned plastic surgeon and star of Botched, Dr. Terry Dubrow, for a “hard questions” episode and some laughs. He educates us on Ozempic/GLP-1 drugs, microdosing, and newer peptide options like tirzepatide and the not-yet–FDA-approved “retatrutide,” which he says may help lower inflammation and support “preservation longevity” while AI accelerates disease breakthroughs. They discuss fears around AI, his belief that people should learn to use it, and his warning about unregulated online/black-market compounds. In beauty, Dubrow urges women to dial back fillers, avoid “Ozempic face panic,” be cautious with deep plane facelifts, and invest more in consistent energy devices (lasers/ultrasound/radiofrequency) rather than extreme procedures. He shares lessons from Botched and Plastic Surgery Rewind, including turning down risky patients, a memorable case removing “concrete” facial injections by reducing—not fully removing—masses, and how he and his wife test wellness trends on their “Doctor and Mrs. Guinea Pig” channel. He also covers peptides uncertainty, cycling use if someone insists, creatine findings, daily visualization, and marriage rules for handling conflict.Find Dr Dubrow - Website: www.drdubrow.com- Instagram: @drdubrow- TikTok: @drterrydubrow- Botched Presents: Plastic Surgery Rewind on E! and PeacockFollow Caroline:- Podcast: https://being-caroline.com/podcast/- IG: https://www.instagram.com/shop.with.caroline/- TikTok: https://www.tiktok.com/@shop.with.caroline- Facebook: https://www.facebook.com/beingcaroline- Search Looks: https://www.shop-with-caroline.com/- Shop New Merch: https://shop.dearmedia.com/collections/coming-in-hotPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Text HOT to 64000 to get twenty percent off all IQBAR products, plus FREE shipping. Message and data rates may apply.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

APR Health Solutions: www.aprhealthsolutions.comOptimize HRT Clinic: https://members.optimize-hp.com - code 'NYLE'Merch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.Peptides we use: www.aprheathsolutions.com (code 'NYLE')To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle

This week's stories: Sinclair's This Is the Test: Are we about to see age reversal in humans? At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets. • Sources: – World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026 – NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair AlphaFold 4 in a locked box: DeepMind's private AI drug design engine Isomorphic Labs, DeepMind's drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs. • Sources: – Nature: https://www.nature.com/articles/d41586-026-00365-7 – Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier Peptides in the freezer: El Mencho's anti aging stash and the dark side of wellness After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides. • Sources: – New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/ – Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954 – Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM The disease we thought was dead: measles comes roaring back Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home. • Sources: – AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026 – ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078 – CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections DC vs your health: Trump's State of the Union health reset President Donald Trump's 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction. • Sources: – Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup – Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/ – This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/ All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update Thank you to our sponsors! Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 0:30 - Story #1: David Sinclair 2026 2:13 - Story #2: Google Drug Discovery 3:48 - Story #3: El Mencho Biohacking5:30 - Story #4: Measles Outbreak 6:51 - Story #5: Trump State of the Union 8:00 - Weekly Roundup 9:10 - Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The State of Hormone & Peptide Industry with Phil Vela Disrupting the health & wellness industry. (2:15) "It's that hard to do IT, so it's that easy to succeed once you've done IT." (2:48) What he did before he started Vita Bella, and the origins of the company. (5:00) The most applicable skills gained from his previous career. (7:41) Calling out the 'Grey Market' and its competition. (9:44) The state of the peptide industry and the fallout with Transcend. (15:54) Results & service. (25:23) Breaking down the Vita Bella membership package. (30:07) Businessman at heart. (33:34) Why he believes it should be illegal to prescribe GLP-1s by themselves. (35:13) Bad actors giving bad guidance. (43:33) His outlook for the future of the industry. (45:14) Will Ozempic and Tirzepatide ultimately bankrupt the United States? (53:27) The importance and value of having a trainer while on a GLP-1. (56:47) "I didn't build this business for money. I built it for a legacy!" (59:07) "Newer" peptides that have been impressed by. (1:03:16) Rapid fire: The best peptide for… (1:11:56) Related Links/Products Mentioned Visit Vita Bella for an exclusive offer for Mind Pump listeners! ** The first 50 signups will get a Vita Bella welcome box. You can finally achieve a top 1% all-around health at an affordable price! ** Get 20% off Kion at getkion.com/mindpump ** No code needed automatically applied at check out! ** MAPS Great 8 Launch - (Retail $127, Code: LAUNCH for 50% off!) ** Launch bonus include: MAPS GREAT 8 Nutrition Guide. ** Visit: http://mapsgreat8.com/  Mind Pump Store Mind Pump Hormones Facebook Private Forum GLP-1 Litigation: Compounder Sues Eli Lilly, Novo Nordisk Mind Pump #2597: Before You Take Ozempic, Wegovy, or Mounjaro Listen to This! Federal Court Tosses Lilly's Suit Against Strive Pharmacy: Jurisdiction Still Matters Mind Pump #2125: Heal Like Wolverine: BPC 157 with Dr. William Seeds Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Phil Vella – "Philly" (@phillyvz) Instagram Jay Campbell (@jaycampbell333) Instagram Rick Niemi (@gods.economy) Instagram Dr. William Seeds (@williamseedsmd) Instagram Peter Attia, M.D. (@peterattiamd) Instagram    

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You'll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. Then the conversation turns into what's new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. You'll Learn: • What peptides are, explained without jargon • Why delivery matters and why pens beat mixing vials all day • How PK curves change real results and dosing schedules • What elamipretide means for mitochondria and longevity • Why MOTS-c can feel like a fast energy shift for some people • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support • Why MK-677 sounds easy but can bring unwanted effects • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss • Why Klotho shows up in longevity research and why dose matters Thank you to our sponsors! • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection Resources: • Get a discount from BIOLONGEVITY LABS by using code ‘Dave' at: https://biolongevitylabs.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:22 – Introduction to Peptides 7:52 – Peptide Delivery Systems & Pens 14:22 – Safety & Regulation of Peptides 19:22 – SS-31 & Mitochondrial Health 26:22 – Blending Peptides & Cross-Linking 38:22 – Growth Hormone Peptides 44:22 – FLGR-242: The New Myostatin Inhibitor 54:22 – Melanin & Consciousness 57:22 – Klotho: The Longevity Peptide 59:25 – Regulatory Landscape & Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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