The study of parasites, their hosts, and the relationship between them
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TWiP describes how a gut commensal protozoan influences respiratory disease outcomes by shaping pulmonary immunity, and body shape variation in lice that parasitize diving hosts. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Gut commensal shapes pulmonary immunity (Cell) The deeper the rounder (Sci Rep) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
A nasty gastro parasite is making its presence felt in the capital with twice the number cryptosporidium cases that would be normal around this time of the year. As of last Thursday, there were 81 confirmed cases reported in the Greater Wellington Region for the year, with the majority reported from mid-March. The bug can cause severe vomiting and diarrhoea and people can be infectious for up to two weeks. Professor of Parasitology from the University of Otago Bruce Russell spoke to Lisa Owen.
TWiP solves the case of the man in the Malaysian city of Kucheng who presents with left arm swelling, and presents a new case for you to decipher. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 257 New Case We are still in Kuching, Malaysia in the northern part of the Island of Borneo. This is the Sarawak portion of Malaysia. A man in his late 30s is admitted to the hospital in December with daily fevers that last for several hours and shaking chills. He had previously been healthy with no medical problems. He lives in the city and works in an office, however, in the few weeks prior to getting admitted he was visiting the jungle. Apparently not too far outside of Kuching, one can go up into the jungle and see Orangutans. He had gone into the jungle but this was 2 weeks prior to the onset of symptoms. Since then he reports no unusual exposures. He lives with his wife and children and they are all healthy. A few days prior to admission he noted fever, chills, and a headache. He is a little nauseated but no vomiting. On exam he has a fast heart rate and appears ill. His respiratory rate is increased and he is not febrile on admission but later does have fever. No enlargement of the liver or spleen on exam. Otherwise unremarkable. His labs are notable for low white blood cells, anemia, and a platelet count of less than 50k per microL. His coagulation studies are abnormal, serum creatinine is elevated, and there is elevation of his serum aminotransferases. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Naegleria fowleri acquired at splash pad (MMWR) Determinants of P. falciparum drug resistance (Science) Paleoparasitological analysis of 5th–16th c. CE latrine (Parasitol) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
The Daily Quiz - Science and Nature Today's Questions: Question 1: What muscle is joined by the lingual nerve to the brain? Question 2: How many faces does a dodecahedron have? Question 3: A male alligator is known as what? Question 4: What is Grossology the study of? Question 5: What is Odontology the study of? Question 6: A Phon is a unit of what? Question 7: What is Parasitology the study of? Question 8: What is the name of the large muscle that covers the shoulder joint? Question 9: What is the word for a group of hawks? This podcast is produced by Klassic Studios Learn more about your ad choices. Visit megaphone.fm/adchoices
Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Michelle Labrunda Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 255 New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves. Hint: this is not Wuchereria Bancrofti. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
In this VETgirl veterinary continuing education podcast, we interview Dr. Michael Dryden, DVM, PhD on all things parasitology. Tune in as we talk about what you need to know to stay up to date on about changing insights to heartworm disease prevention and resistance to this life-threatening disease!Sponsored By: Boehringer Ingelheim
TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP solves the case of the man with somnolence and something extra-erythrocytic, and presents a new puzzle for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 253 New Case 26-year-old female with no past medical history. Patient is from Georgia in the US and is volunteering in Hérico, Guinea (town in the Lélouma Prefecture in the Labé Region of northern-central Guinea). She arrived in Guinea in December 2023. She was taking doxycycline for malaria prophylaxis and says that she has not missed any doses On October 2024 she presented with fever and dry cough. Lab work was done and follow up planned for the following day. The patient slept poorly, was febrile to 104 and had ongoing cough. The next day she went to the hospital and was evaluated in the ER for acute febrile illness of unclear etiology. In the hospital, VS were 97.9F, BP 105/70, P 94 Oxy sat 98%, normal physical exam. She was started on Augmentin and Coartem. Pause here to think about the differential at this point and maybe some more history and what testing you might want WBC 14, Hb 13, HCT 40, PLT 285, Neut abs 8, Eos Abso0.80; BUN/creat normal, AST normal; ALT 44, GGT 125 Stool parasite screen + for some sort of eggs, malaria smear negative, CXR with b/l infiltrates She was given a medication (vomited 30 min after dose received). She then received a second dose of medication 5 hours after the first) and was discharged. The following day the patient returned to the ER, stating that she felt worse. Her temperature had climbed to 104 overnight, and she developed watery diarrhea and nausea. There were no additional episodes of vomiting. She was given an additional dose of a medication, ibuprofen, and started on ceftriaxone 1 gm IV Q12 hrs. During the day she continued to have low grade fevers and developed abdominal pain. That night she was again febrile to 104 F. She remained admitted for 5 days with ongoing symptoms of diarrhea, nighttime fevers and diffuse abdominal discomfort. Three more malaria tests were negative (rapid test and slide review) Blood cultures collected – no growth She continued to have mild elevation of WBC and slight elevation of AST and ALT. The patient was transferred to a different hospital. They give her a different medication, and within 24 hours symptoms resolve. What is the diagnosis and what happened here with management? Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP discusses a study of the safety and immunogenicity of a late liver-stage attenuated malaria parasite delivered by mosquito bite. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Live attenuated malaria vaccine (NEJM) Plasmodium metabolism during hepatic development (Cell) Heroes – Jimmy and Rosallyn Carter, and the Carter Center The Carter Center Guinea Worm Eradication Programme Guinea Worm data visualisations (Our World in Data) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
CORDIScovery – unearthing the hottest topics in EU science, research and innovation
Why is it so hard to find a vaccine that works well against placental malaria? Ever thought about the challenges of irradiating 300 mosquitoes a second! And how do the dynamics of replication play out in our bodies? Malaria is described by the World Health Organization as ‘perpetuating a vicious cycle of inequity'. Listen on to see how EU scientists are working to understand and mitigate the disease. Catherine Merrick is professor of Parasitology in the Pathology Department at Cambridge University. She studies the human malaria parasite, aiming to improve our understanding of the fundamental biology of the parasite, and the impact of this biology on virulence. Lars Hviid is professor in the Department of Immunology and Microbiology, at the University of Copenhagen. His work has improved our understanding of how people gradually acquire protection from malaria, and furthered the development of vaccines against this deadly parasite. Hanan Lepek is the founder and CEO of Senecio Robotics. He works at the interface of biology and mechanical and software engineering, to create and deploy sterile mosquitoes on a large scale to reduce local mosquito populations.
TWiP solves the case of the woman who went to Belize and notices a lesion on her face, and presents a new clinical case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 251 New Case Recent case, Arusha hospital, 1800 m, 28 yo comes in, has been visiting game parks. Developing fevers, malaise, bad headaches, body aches, somnolent. Blood smears negative, no malaria. Repeat blood smear, see something extra-erythrocytic. This gives them the diagnosis. HIV neg, no toxic habits, no history. Symptom onset about a week ago. Rest of family is ok. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP reviews a study showing that the gut microbiota is essential for suppression of colitis by Trichinella spiralis. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Gut bacteria and Trichinella suppression of colitis (PLoS NTD) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP solves the case of the middle-aged man with eosinophilia and a history of sexual activity with paid sex workers in Okinawa, and presents a new case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 249 New Case Woman in 30s or 40s goes to Belize and after returning notices a lesion on her face. She goes to see several physicians and despite a number of topical creams the ulcer on her face does not heal. She is then referred to our office where a certain parasitic infection is considered and we involve our friends at Columbia to help us with the diagnosis.. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP reviews the observation that infection of Azlheimer's disease mice with Toxoplasma gondii reduces brain amyloid density globally and regionally. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Toxoplasma reduces amyloid in brain (J Inf Dis) Hero: Theodor Hiepe (Parasitol Res) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Dr. Karine Gaelle Le Roch is a Professor in the Department of Molecular, Cell and Systems Biology and Director of the Center for Infectious Disease and Vector Research at the University of California, Riverside. Karine's research focuses on parasites, and much of her work has focused on the parasite that causes malaria in humans. She is working to better understand the life cycle of the parasite, how the molecular components in its body work together, and how the parasite's function can be disrupted after a person has been infected in order to treat and cure malaria. When she's not doing science, Karine enjoys sailing in the San Diego Bay, skiing in the winter, spending time with her son, and watching him play soccer. She received her BA in Biochemistry and Microbiology from the University Paris-Sorbonne, her MS in host-parasite interactions between Oxford University in the UK and the University of Lille in France, and her PhD in Parasitology and host-parasite interactions from the University Paris-Sorbonne. Afterwards, she conducted postdoctoral research at The Scripps Research Institute in La Jolla and subsequently she was an Institute Fellow at the Genomics Institute of the Novartis Research Foundation. Karine joined the faculty at UCR in 2006. She has earned various honors and awards throughout her career, including the Academic Senate Regent Award for Outstanding Research from the University of California, she was a participant in the Provost Faculty Leadership Program at UCR and the University of California's Women's Initiative for Professional Development. In our interview, Karine shares more about her life and science.
TWiP solves the case of the Manhattan man with pain on urination or ejaculation, and presents a new case for you to solve. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Hero: Charles Louis Alphonse Laveran Letters read on TWiP 247 New Case A middle-aged male is referred to evaluation because of eosinophilia. This man is married, living here in the NY tristate area, and this was picked up on ‘routine blood work' by his primary care doctor. This man had been in the military, serving as a marine, with time spent in Okinawa, Japan. This individual does report sexual activity with paid sex workers while in Okinawa but has been monogamous with his current wife for many years. A number of investigations are done with a test coming back showing serological evidence of a prior parasitic infection and he was treated with an antiparasitic medicine with resolution of the eosinophilia. The eosinophilia returned and he was referred to us. Blood work is now down showing evidence of a viral infection that might explain why the eosinophilia returned after treatment. Pt is HIV negative. This was prior to the COVID-19 pandemic. He is on no medications and in general feels fine. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP taps into Dickson's knowledge of Trichinella to discuss an outbreak in humans who consumed rare bear meat, and the impact of globalization and climate change on the epidemiology of the species. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Outbreak of human trichinellosis (CCDR) Impact of climate change on Trichinella (Food Waterborne Parasit) Letters read on TWiP 246 Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Founder of Floating Doctors Ben LaBrot joins TWiP to solve the case of the 1 year old in northeastern Panama with a fatal leg infection, followed by a discussion of the history and mission of Floating Doctors. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Ben LaBrot Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Floating Doctors Letters read on TWiP 245 New Case A man in his early 20s comes in reporting pain when he urinates or ejaculates. He reports that he is sexually active. He does confide that he has been in a relationship with a woman but he had a sexual encounter outside this relationship about 2 weeks ago when they were on a break and he did not wear protection. He feels like he needs to urinate more often and describes thin white discharge from the penis. He reports that he has no history of any sexually transmitted infections and had no medical issues prior to this. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Imagine tapeworms longer than the height of an adult human. Or microbes that turn their hosts into zombies. If the revulsion they induce doesn't do it, the sheer number of parasites force us to pay attention. They are the most abundant form of animal life on Earth. Parasites can cause untold human suffering, like those that cause African River Blindness or Lyme disease, but their presence is also a sign of a health ecosystem. A parasitologist whose lab contains the largest parasite collection in the world gives us the ultimate inside story about these organisms. Guest: Scott Gardner - curator of parasites in the H.W. Manter Laboratory of Parasitology at the University of Nebraska State Museum, one of the largest collections of parasites in the world, and professor of biological sciences at University of Nebraska. Co-author of Parasites: The Inside Story. Featuring music by Dewey Dellay and Jun Miyake Originally aired July 31, 2023 Big Picture Science is part of the Airwave Media podcast network. Please contact advertising@airwavemedia.com to inquire about advertising on Big Picture Science. You can get early access to ad-free versions of every episode by joining us on Patreon. Thanks for your support! Learn more about your ad choices. Visit megaphone.fm/adchoices
Imagine tapeworms longer than the height of an adult human. Or microbes that turn their hosts into zombies. If the revulsion they induce doesn't do it, the sheer number of parasites force us to pay attention. They are the most abundant form of animal life on Earth. Parasites can cause untold human suffering, like those that cause African River Blindness or Lyme disease, but their presence is also a sign of a health ecosystem. A parasitologist whose lab contains the largest parasite collection in the world gives us the ultimate inside story about these organisms. Guest: Scott Gardner - curator of parasites in the H.W. Manter Laboratory of Parasitology at the University of Nebraska State Museum, one of the largest collections of parasites in the world, and professor of biological sciences at University of Nebraska. Co-author of Parasites: The Inside Story. Featuring music by Dewey Dellay and Jun Miyake Originally aired July 31, 2023 Big Picture Science is part of the Airwave Media podcast network. Please contact advertising@airwavemedia.com to inquire about advertising on Big Picture Science. You can get early access to ad-free versions of every episode by joining us on Patreon. Thanks for your support! Learn more about your ad choices. Visit megaphone.fm/adchoices
Lilach Sheiner joins TWiP to talk about her career and her work on engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Hosts: Vincent Racaniello, Dickson Despommier, and Christina Naula Guest: Lilach Sheiner Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Engineering T. gondii for protein secretion (Nat Micro) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP solves the case of the Woman with White Worms, and submits a new case involving a 1 year old in northeastern Panama with a fatal leg infection. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Enterobius, the pinworm (TWiP 19) Hero: Mary Pritchard New Case This case comes from Panama mid summer 2024. A provider for Floating Doctors working in the coastal region in northeastern Panama. This case involves a one year old, so the history is a bit difficult, but there may have initially been a scratch or some sort of break in the skin. Otherwise healthy but over a period of time this area expands and becomes a deep necrotic wound on the leg. Several other nearby wounds develop and become deep and infected. By the time this one year old is seen by the provider much of the leg appears eaten away. This is just the tip of the iceberg as a number of others develop similar wounds in the area. No prior medical history. Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP reviews a study showing that intestinal helminth infection impairs vaccine-induced T cell responses through an IL-10 pathway, which compromised protection against antigenically drifted SARS-CoV-2 variants. Hosts: Vincent Racaniello, Daniel Griffin and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Worms impair COVID vaccines (Sci Trans Med) Heligmosomoides image (Wiki Commons) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
In this episode of South Pole, host Clark Marchese interviews Dr. Soledad Leonardi, a parasitologist at the National Research Council in Argentina, about her research on the fascinating interactions between elephant seals and seal lice in Antarctica. They discuss the coevolution of these species, the role of seal lice in disease transmission, and how these parasites have adapted to the extreme conditions of the Southern Ocean. Dr. Leonardi also shares insights into how climate change could impact this delicate relationship and the broader Antarctic ecosystem. Tune in to learn about the unique challenges and discoveries in studying one of the few marine insects in the world.Episode Guest: Dr. Soledad LeonardiBrowse Dr. Soledad Leonardi's publications hereFollow Dr. Soledad Leonardi on X More information about the National Research Council Argentina hereEpisode Transcript and more information on the Pine Forest Media WebsiteFollow Pine Forest Media on Instagram @pineforestmediaHosted, produced, written, and edited by Clark Marchese Cover art and PFM logo by Laurel Wong. Theme music by Nela Ruiz Hosted on Acast. See acast.com/privacy for more information.
Sean Murphy joins TWiP to discuss his career and the work of his laboratory to assess the daily natural history of asymptomatic Plasmodium infections in adults and older children in Katakwi, Uganda. Hosts: Vincent Racaniello, Dickson Despommier and Christina Naula Guest: Sean Murphy Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Daily natural history of Plasmodium infections (Lancet Microbe) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Last year, almost half of the honeybee colonies in the U.S. died, making it the second deadliest year for honeybees on record. The main culprit wasn't climate change, starvation, or even pesticides, but a parasite: Varroa destructor.“The name for this parasite is a very Transformer-y sounding name, but … these Varroa destructor mites have earned this name. It's not melodramatic by any means. [They are] incredibly destructive organisms,” says Dr. Sammy Ramsey, entomologist at the University of Colorado Boulder.These tiny mites feed on the bees and make them susceptible to other threats like diseases and pesticides. They're also highly contagious: They arrived in the US in 1987, and now they live in almost every honeybee colony in the country. Honeybees pollinate many important crops, like apples, peaches, and berries, and their pollinator services add up to billions of dollars.Ramsey and his lab are trying to put an end to the varroa mites' spree. Part of their research includes spying on baby bees and their accompanying mites to learn how the parasites feed on the bees and whether there's a way to disrupt that process.In Boulder, Colorado, SciFri producer Rasha Aridi speaks with Dr. Ramsey and fellow entomologist Dr. Madison Sankovitz about how the varroa mites terrorize bees so effectively, and what it would take to get ahead of them.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.
TWiP solves the case of the AIDS patient who developed fever and watery diarrhea after drinking NYC tap water, and present a new case for your sleuthing. Hosts: Vincent Racaniello and Daniel Griffin Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Cryptosporidium (TWiP 18) Letters read on TWiP 239 Become a patron of TWiP New Case Man in his 70s originally from Mainland China, then Hong Kong who has been living in the US for decades is admitted to the hospital with fever for 6 days. He reports that he saw his primary care physician in Queens and was referred to the hospital after blood work revealed a sodium level of 123 and an increased monocyte count. Pt reports drenching sweats, lots of outdoor activity walking in local parks in Queens. He reports he does not feel particularly sick. PMH-HTN, BPH PSH-neg Social-retired, no wife, has one son, no pets, no exotic exposures or recent travel VS febrile to 39.5, tachycardia, meets sepsis criteria PE -unremarkable Labs, nl wbc, eos-0, elevated neutrophils and monocytes, Na-123, elevated AST, elevated ALT, low platelets, low Hct, CT Chest A/P unremarkable Send your guesses to twip@microbe.tv with TWiP 239 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Episode Notes Parasites and other diseases* Mitchell, Piers D. 2024. Chapter two - parasites in ancient Egypt and Nubia: malaria, schistosomiasis and the pharaohs. Advances in Parasitology 123, 23-49. DOI: 10.1016/bs.apar.2023.12.003* Metwaly AM, Ghoneim MM, Eissa IH, Elsehemy IA, Mostafa AE, Hegazy MM, Afifi WM, Dou D. Traditional ancient Egyptian medicine: A review. Saudi J Biol Sci. 2021 Oct;28(10):5823-5832. doi: 10.1016/j.sjbs.2021.06.044. Epub 2021 Jun 19. PMID: 34588897; PMCID: PMC8459052.* The Art of Medicine in Ancient EgyptReligion, Cult and Morality* Kemp, B. J. (1995) How Religious were the Ancient Egyptians? Cambridge archaeological journal. [Online] 5 (1), 25–54.* Van Blerk, N. (2019) The ancient Egyptians' “Religious World” : the foundation of Egyptian law. Journal for Semitics. [Online] 28 (1), 1–20.* Crime and punishment* Law in Ancient Egypt“New” Nile Branch* The Egyptian pyramid chain was built along the now abandoned Ahramat Nile BranchCultural Memory in ancient Egypt and Nubia* Prehistoric Egypt* Newman, J. & Wendrich, W. (2022) ‘Neolithic and Predynastic Egypt', in Reference Module in Social Sciences. [Online]. Elsevier Inc. p.* British Museum- Egyptian rock art* EES- Drawings along the Nile * Wadi Hammamat Project Valley of the Queens* AMAZING website charting all the tombs- Valley of the Queens and Western Wadis Get full access to Ancient/Now at ancientnow.substack.com/subscribe
Michael Barrett joins TWiP to discuss progress in the elimination of human African trypanosomiasis caused by Trypanosoma brucei gambiense. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Michael Barrett Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Elimination of human African trypanosomiasis (PLoS NTD) Hero: David Livingstone Become a patron of TWiP Send your guesses to twip@microbe.tv with TWiP 237 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Je kunt wel stellen dat er vandaag niet zomaar iemand aan tafel zit, en al helemaal niet iemand die je in het "antivaxxer"-hokje kunt stoppen. Prof. Dr. Theo Schetters is immunoloog en vaccinoloog. Hij is verbonden aan de universiteit van Pretoria in Zuid-Afrika en heeft bijgedragen aan de ontwikkeling van diverse vaccins. Hij is onderscheiden met een Medal of Honor van de faculteit Pharmacy van de Universiteit van Montpellier in Frankrijk en is lid van de editorial board van het wetenschappelijke tijdschrift Parasitology van Cambridge University Press. Daarnaast is hij directeur bij ProdActivity, dat zich richt op de ontwikkeling van vaccintechnologie. In de corona periode bleek Theo een gevaarlijk man voor veel grote instanties. Hij uitte al in een zeer vroeg stadium zijn kritiek en zorgen omtrent de massavaccinatie, wat er onder andere voor zorgde dat hij binnen no-time van LinkedIn werd gegooid. In dit gesprek legt Theo uit waarom hij zich grote zorgen maakt over de gevolgen van het mRNA-vaccin. "De mRNA-technologie is nog niet af. Er gebeurt nog zoveel meer in het lichaam dan waar het voor bedoelt is; het gaat overal heen." Daarnaast stelt hij dat het wishful thinking is om te zeggen dat mRNA niet in de celkern komt. "Ik zie een hele hoop obstakels waarom we dit niet moeten doen." Jorn en Theo praten over die afgelopen vier jaar, over hoe Theo zich staande heeft gehouden en hoe hij aankijkt tegen gezondheid en ziek zijn. "Onderschat niet wat een ziekteproces is. Ziek zijn heeft een effect op je immuunsysteem. Je traint je lichaam en dat maakt jou tot een gezond mens. Als niemand meer ziek mag worden houden we een hele kwetsbare populatie over. Dat is goed nieuws voor big pharma, maar niet voor de mensen." Ga ‘m luisteren! Deze aflevering is ook te zien op het That's The Spirit videoplatform, inclusief kijkersvragen. Laat ons vooral weten wat je van de aflevering vond! Ps. Mensen die te maken hebben met klachten rondom long-covid of spike proteïnen kunnen baat hebben bij het consumeren van curcumine honing of Curcubron. Dit laatste is een detox recept, samengesteld volgens het onderzoek en de receptuur van dr. Peter Mc Cullough en is een mix van watertoegankelijke curcumine, bromelaïne, nattokinase en Blue Earth Elixer. Het is geheel natuurlijk zonder kunstmatige toevoegingen. STEUN The Trueman Show: https://doneren.thetruemanshow.com/ ABONNEER op onze nieuwsbrief: http://www.thetruemanshow.com WORD MEMBER van ons platform That's The Spirit: https://thatsthespirit.nu/ VOLG ons op Instagram: https://www.instagram.com/thetruemanshowpodcast/ Facebook: https://www.facebook.com/jornluka/ STUUR je kijkersvragen in via Telegram: https://t.me/s/jornluka?before=217
VetFolio - Veterinary Practice Management and Continuing Education Podcasts
In this CE episode of the VetFolio Voice podcast, Dr. Cassi chats with Dr. Kathryn Reif, the Bailey-Goodwin Endowed Chair in Parasitology at Auburn University's College of Veterinary Medicine, about her research on ticks and tick-borne diseases. Ticks are spreading and can make both animals and people seriously sick, which is why considerations such as speed of kill are more important than ever when deciding on tick protection for your patients. This episode is sponsored by Credelio® (lotilaner), an Elanco product.
Marilyn Fabbri joins TWiP to reveal the case of a patient who became very ill after he and a number of friends attended a large dinner where venison and boar were served. Hosts: Daniel Griffin, Dickson Despommier and Christina Naula Guest: Marilyn Fabbri Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Toxoplasma gondii (TWiP 12) Parasitic Diseases Lectures #15: Toxoplasmosis Letters read on TWiP 237 Become a patron of TWiP New Case Man in his 60s with HIV/AIDS CD4 count less than 50, CD4% less than 5% and elevated viral load (VL) with report of prior CNS toxoplasmosis requiring a craniotomy, disseminated Mycobacterium avium complex (MAC), comes in with fever and very watery diarrhea x 4 days. He reports that he lives in Georgia but comes up to NY for his HIV care and stays in NYC. Send your guesses to twip@microbe.tv with TWiP 237 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Marion Avril of MalarVx, Inc. joins TWiP to discuss an accelerated prime-and-trap regimen using repRNA-based circumsporozoite vaccine. Hosts: Dickson Despommier and Christina Naula Guest: Marion Avril Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute repRNA-based CSP malaria vaccine (NPJ vaccines) Hero: Mwelecele Ntuli Malecela Become a patron of TWiP Send your guesses to twip@microbe.tv with TWiP 235 in the subject line Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP solves the case of a man in his 50s reporting months of abdominal discomfort, who takes mebendazole and some time afterwards vomits a worm into the sink. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute The giant intestinal worm, Ascaris lumbricoides (TWiP 21) Parasitic Diseases Lectures #24: Giant Intestinal Worm (YouTube) Letters read on TWiP 235 Hero: Ernst A. H. Friedheim Become a patron of TWiP New Case: I first learned about this case from a colleague at work who tells me that their friend has just gotten really sick. The friend is described as having had multiple illnesses over time but that he has never been as sick as he recently got. He reports that the illness began as a diffuse myalgia with fever, there was some sore throat, noted swelling in the neck, and overwhelming fatigue. He tells some of his friends that he is feeling really terrible and it turns out that some of his friends also feel poorly. It turns out that about a week prior to the onset of his symptoms he and a number of friends attended a large dinner where venison and boar was served. This individual is then seen in our office. Some testing is done. He feels really terrible and despite being reassured that he should get better without treatment he is given therapy. Send your guesses to twip@microbe.tv with TWiP 235 in the subject line Send your questions and comments to twip@microbe.tv
TWiP discusses hookworm infection and the phase 1 clinical trial for a hookworm vaccine that could one day protect children from the hookworm anaemia, and reduce transmission of this infection. Hosts: Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hookworm vaccines in school-aged children in Gabon (Lancet Inf Dis) Step forward towards hookworm vaccines (Lancet Inf Dis) Hookworm vaccine protects dogs (FASEB J) Hero: Muriel Robertson Letters read on TWiP 233 Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP solves the case of the physician with no significant previous medical history who is currently doing their fellowship training develops diarrhea, and presents a new clinical case for our astute listeners to solve. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Keith Vickerman Letters read on TWiP 233 Become a patron of TWiP New Case study: I was recently asked about this case while I was off visiting Denmark. A man in his 50s has been reporting months of abdominal discomfort and decides to go discuss this situation with a local pharmacist. He describes this discomfort, some nausea, and some bloating of the abdomen. The pharmacist recommends that he take mebendazole. He takes the mebendazole and some time afterwards he vomits a worm into the sink. The worm does not have any obvious segmentation and appears completely nonsegmented and is moving around. One end is very pointy and the other little less so. Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP reviews the cellular lives of Wolbachia, a gram-negative bacteria that infects many arthropods and filarial nematodes with very different outcomes – parasitism or mutualism. Hosts: Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Cellular lives of Wolbachia (Nat Rev Micro) Hero: Patricia F. Walker Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP solves the case of the Woman With White Worms, and presents a new clinical case to decipher. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Please support our work at microbe.tv/contribute Hero: Ann Bishop Become a patron of TWiP New Case study: A physician with no significant PMH who is currently doing their fellowship training develops diarrhea. The diarrhea is significant enough that they are beginning to feel weak, lightheaded, and end up going to the local ER. The physician lives in NYC, works most of the time but did just get back from a week-long vacation in Florida with their long-term partner where they got a chance to swim in the pool and get some sun. They returned feeling well and then noted the onset of the diarrhea. The diarrhea was watery, with some abdominal cramping but no noted blood or actual fever. The stool did not have a strong smell and no floating stools were reported. The physician was given IVF and returned home feeling better but now gets a call that there is a parasite on the stool testing and is recommended to take a medicine they have never heard of 3x per day for 3 days. Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Dr. Rick Gerhold, Associate Professor of Parasitology/Wildlife Diseases at the University of Tennessee, joins us to breakdown common diseases among turkeys and their symptoms, pathways of transmission, and infected biological effects. He also discusses histomonas and how you can get involved in cutting-edge egg research. Dr. Rick Gerhold (rgerhold@utk.edu) (Academic Profile) Donate to wild turkey research: UF Turkey Donation Fund , Auburn Turkey Donation Fund Dr. Marcus Lashley (@DrDisturbance) (Academic Profile) Dr. Will Gulsby (@dr_will_gulsby) (Academic Profile) Turkeys for Tomorrow (@turkeysfortomorrow) UF DEER Lab (@ufdeerlab) (YouTube) Please help us by taking our (QUICK) listener survey - Thank you! https://ufl.qualtrics.com/jfe/form/SV_3VR10xcKOMTvZH0 Watch these podcasts on YouTube: Wild Turkey Science YouTube This podcast is made possible by Turkeys for Tomorrow, a grassroots organization dedicated to the wild turkey. To learn more about TFT, go to turkeysfortomorrow.org. Help us help turkeys by rating this podcast and sharing it with your friends and family. Music by Artlist.io Produced & edited by Charlotte Nowak
Maria Adelaida Gomez joins TWiP to discuss her career and the work of her laboratory on understanding the healing process during cutaneous leishmaniasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Maria Adelaida Gomez Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CIDEIM Healing in cutaneous leishmaniasis (J Immunol) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Eyal joins TWiP to solve the case of the Female Traveler with Intermittent Fever and Ring Enhancements in the Liver. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Eyal Leshem Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Become a patron of TWiP Case Study for TWiP 229 Woman in her 40s is referred to me to be seen in the office from one of my colleagues. She reports that she has been having recurrent issues with worms exiting her anus and vagina since 2018. She reports that she lives with her husband and 4 children and they have never reported any issues. She reports that initially she took something over the counter and things resolved. She then a couple years later has this problem again and this time discussed the problem with her housekeeper from El Salvador who gave her an antiparasitic tablet from her home country. This problem has now recurred and she was referred to a GI doctor who she explains laughed at her and suggested she see a psychiatrist. She come in now very upset and tearful. She relates that she has this itching that wakes her up at night and was able to take pictures of something she found on the anus. She has photos as well as a video of a thin white 1 cm motile thing with on end coming to a point. She reports a normal nonrestrictive diet. She reports no travel outside the US or even outside the local area. No PMH, no PSH, family history of different cancers. She does not work outside the home. She reports no pets. She has an unremarkable exam and labs only notable for low vitamin D. Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Title of episode: Leishmania in Dogs and Cats Category: Immune System, Parasitology, Zoonotic Disease Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, VTS SAIM as we talk about: Leishmaniosis in Dogs and Cats! It's a crazy parasite that is zoonotic and not something to mess around with. Resources We Mentioned in the Show Parasites - Leishmaniasis from the CDC https://www.cdc.gov/parasites/leishmaniasis/index.html Leishmaniasis from the World Health Organization https://www.who.int/news-room/fact-sheets/detail/leishmaniasis Leishmaniosis in Dogs from Merck Manual https://www.merckvetmanual.com/generalized-conditions/leishmaniosis/leishmaniosis-in-dogs Leishmaniosis (Visceral Leishmaniasis) in Dogs from Merck Manual https://www.merckvetmanual.com/dog-owners/disorders-affecting-multiple-body-systems-of-dogs/leishmaniosis-visceral-leishmaniasis-in-dogs Canine Leishmaniasis: Update on Epidemiology, Diagnosis, Treatment, and Prevention https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416075/ Don't forget to check out LoveHuvet.com and use our discount code IMFVT10 to receive 10% off your order! Thanks so much for tuning in. Join us again next week for another episode! Want to earn some RACE approved CE credits for listening to the podcast? You can earn between 0.5-1.0 hour of RACE approved CE credit for each podcast episode you listen to. Join the Internal Medicine For Vet Techs Membership to earn and keep track of your continuing education hours as you get your learn on! Join now! http://internalmedicineforvettechsmembership.com/ Get Access to the Membership Site for your RACE approved CE certificates Sign up at https://internalmedicineforvettechsmembership.com Get Access to the Technician Treasure Trove Sign up at https://imfpp.org/treasuretrove Thanks for listening! – Yvonne and Jordan
TWiP discusses a tapeworm that causes extreme lifespan extension in infected ant workers, and a candidate antibody drug for prevention of malaria. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Extreme lifespan extension in tapeworm-infected ant workers (Roy Soc Open Sci) Candidate antibody drug for prevention of malaria Ceilidh goes viral (YouTube) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
The connection between alcohol and gut health is established in scientific literature: alcohol is an inflammatory agent. But as researchers like Vincent Maffei work to improve the quality of life for HIV patients, every bit of information of how that inflammation develops makes a difference, especially in how alcohol and bowel problems connect. Listeners will learn The difference between chronological and biological health and how HIV patients experience increased biological aging, The connection between alcohol and G.I. issues, particularly less diverse microbiota, and The significance of their findings, specifically the abundance of Prevotella spp., a bacteria that may be a mediator between alcohol and cell senescence. Vincent J. Maffei is with the Department of Microbiology, Immunology, and Parasitology at LSU. As a graduate student, he became involved in LSU's Comprehensive Alcohol Research Center (CARC) and studied how dysbiosis accompanies biological aging. He combined this with studying how alcohol affects the intestines, and now studies this specifically with HIV patients. More specifically, he works to find associations between alcohol use and advancing aging in HIV patients and their guts. He explains to listeners about several players in this complex mix of cause and effect: alcohol and gut health as well as alcohol and HIV patients. He establishes that any amount of alcohol can be harmful to someone suffering from HIV. Combine that with an already-established connection with alcohol and dysbiosis in the gut, and researchers are faced with a very real problem to solve for these patients. He does a careful job explaining the background to listeners, bringing in other studies more general to alcohol use and explaining its effect on T-cell senescence, which basically means they lack the ability to copy themselves—limiting their ability to fight infection. Senescence is also a characteristic of biological aging. He explains that the administration of alcohol breaks down the gut barrier, allowing microbes to migrate from the lumen of gut into tissue, which causes inflammation. He also explains their worthy end goal: to identify some sort of microbiota intervention to relieve this component of inflammation in HIV patients, improving their life span and quality of life. Hopefully their findings will lead to more precise mechanisms that can be leveraged in therapeutic modality. For more, see the CARC website: medschool.lsuhsc.edu/alcoholresearch. Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: apple.co/30PvU9C
Jim Small joins TWiP to solve the case of the 41 year old Man with sudden GI distress and itchy hives, followed by a discussion of parasites and childhood stunting. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Jim Small Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Parasites and childhood stunting (Trends Parasitol) Letters read on TWiP 227 Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
TWiP reviews some parasite stories of 2023, including progress in the control of malaria and polio, and review a connection between parasites and childhood stunting. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Second malaria vaccine (Nature) Malaria report 2023 (WHO) Malaria and climate change (WHO) Parasites and childhood stunting (Trends Parasitol) Sea creature spotted off Japan identified (Science) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees
Lee Gottesdiener joins TWiP to help solve the case of the 46 Year Old Man with Ongoing Upper Extremity Swelling, and review plant‑based production of a protective vaccine antigen against the bovine parasitic nematode Ostertagia ostertagi. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Vaccine against cow parasite (Vert Farm Daily) Protective vaccine against bovine parasitic nematode Ostertagia ostertagi Hero: Dr. Katy Ewer Letters read on TWiP 225 Become a patron of TWiP Case Study for TWiP 225 41-year-old male mechanical engineer, former Army Ranger trainee, moved from Denver, CO to Chattanooga, TN. He was in his usual state of vigorous health, hiking, doing Spartan races, working on his semi-rural property, and commuting to his place of work daily when about three months previous to his diagnosis, he began having episodes of sudden GI distress with diarrhea, followed by itchy hives in axilla and groin. He treated these episodes with Benadryl and got relief. At 10 PM one evening, he had another such episode, again took Benadryl, but began to experience gradual onset but relentlessly increasing shortness of breath and wheezing. He was taken at high speed to the Emergency Room by his wife. He reported that relaxation with a repetitive, meditative prayer seemed to control the symptoms but said it was like his throat was closing. Past history includes variable exercise and cold-induced asthma treated with an inhaler as a child, with only rare episodes in adulthood related to high exposure to allergens like cat dander. Family history is not contributory. Diet was omnivorous. They had one dog, a labradoodle named Raphael, which they chose because he was “hypoallergenic.” In the Emergency Department, he was treated with bronchodilators, intramuscular epinephrine, and antihistamines, and the symptoms abated. The experienced ED physician ordered a diagnostic test, having seen other similar cases in the region. A lifestyle intervention was successful.
Chuck Knirsch returns to TWiP to discuss the Neglected Tropical Diseases Roadmap published by WHO, which sets global targets and milestones to prevent, control, eliminate or eradicate 20 diseases and disease groups. Chuck Knirsch returns to TWiP to discuss the Neglected Tropical Diseases Roadmap published by WHO, which sets global targets and milestones to prevent, control, eliminate or eradicate 20 diseases and disease groups. Hosts: Vincent Racaniello, Dickson Despommier, and Chuck Knirsch Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Neglected Tropical Diseases Roadmap (WHO) World malaria report 2023 (WHO) Become a patron of TWiP Send your questions and comments to twip@microbe.tv