Podcasts about Neuroimmunology

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Neuroimmunology

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Best podcasts about Neuroimmunology

Latest podcast episodes about Neuroimmunology

Immune
Immune 92: Gut symbiont breaks antibody

Immune

Play Episode Listen Later May 27, 2025 80:33


Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Gut bacteria induce mucosal immunodeficiency (Science) Contribution of fetal mononuclear phagocytes to Zika virus neuroinvasion (Cell) TWiV468 discusses Zika and brain slice infection model. Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Neurology Minute
Neuroimmunology Update 2025: Autoimmune Encephalitis Outcomes

Neurology Minute

Play Episode Listen Later May 13, 2025 2:43


Dr. Justin Abbatemarco discuss autoimmune encephalitis with a focus on outcomes.  Show reference:  https://www.neurology.org/doi/10.1212/WNL.0000000000210109  https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00463-5/abstract 

Neurology Minute
Neuroimmunology Update 2025: MOGAD Treatments

Neurology Minute

Play Episode Listen Later May 7, 2025 2:41


Dr. Justin Abbatemarco discusses updates around MOGAD treatments.  Show references: https://jamanetwork.com/journals/jamaneurology/article-abstract/2822964  https://jnnp.bmj.com/content/95/11/1054 

Neurology Minute
Neuroimmunology Update 2025: Autoimmune Encephalitis Outcomes

Neurology Minute

Play Episode Listen Later May 6, 2025 2:45


Dr. Justin Abbatemarco discusses autoimmune encephalitis with a focus on outcomes. Show references: https://www.neurology.org/doi/10.1212/WNL.0000000000210109  https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(23)00463-5/abstract 

PN podcast
Fragmented sleep with delusions of theft, and falls after eye shingles - Case Reports April 2025

PN podcast

Play Episode Listen Later May 6, 2025 36:51


Two wide open cases from the latest issue of the journal. Starting with a case from Italy (1:18), of a 63-yo man having a history of behavioural and cognitive problems since retiring. His many changes included low mood, significant weight loss, and problems with sleep and temperature regulation. He had a background of type 2 diabetes. Initial treatment was on a suspicion of Alzheimer's, but there was no clinical improvement. https://pn.bmj.com/content/25/2/159  A case from the United States is next (17:36), featuring a 66-yo lady experiencing 10 days of generalised weakness, with episodes of forgetfulness and a series of falls. She had previously been treated for left-sided ophthalmic herpes zoster. Neurological examination showed mild right arm and leg weakness. https://pn.bmj.com/content/25/2/164    The case reports discussion is hosted by Prof. Martin Turner¹, who is joined by Dr. Ruth Wood² and Dr. Babak Soleimani³ for a group examination of the features of each presentation, followed by a step-by-step walkthrough of how the diagnosis was made. These case reports and many others can be found in the February 2025 issue of the journal. (1) Professor of Clinical Neurology and Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, and Consultant Neurologist at John Radcliffe Hospital. (2) Neurology Registrar, University Hospitals Sussex. (3) Clinical Research Fellow, Oxford Laboratory for Neuroimmunology and Immunopsychiatry, Nuffield Department of Medicine, University of Oxford Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Brian O'Toole. Thank you for listening. 

Neurology Minute
Neuroimmunology Update 2025: AQP4+ NMOSD Treatment Landscape

Neurology Minute

Play Episode Listen Later Apr 30, 2025 3:25


Dr. Justin Abbatemarco discusses updates around treatments in AQP4+ NMOSD.  Show references: https://pubmed.ncbi.nlm.nih.gov/38760098/ https://www.neurology.org/doi/10.1212/NXI.0000000000200071  

Live Well Be Well
The Brain-Immune Expert: This Is How Social Media Is Reprogramming Your Immune System | Dr. Dan Nicolau

Live Well Be Well

Play Episode Listen Later Apr 30, 2025 71:38


I'm excited to share this week's Live Well Be Well episode with you all! I had Dr. Dan Nicolau join me to explore the fascinating intersection of our brain and immune system - a relationship that could completely transform how we understand health and disease."Neuroimmunology" - the powerful two-way communication between our brain and immune system. We often think of these systems separately, but Dan reveals how they're constantly in dialogue, influencing everything from allergies and autoimmune conditions to mental health and chronic disease.We dive into how modern life - particularly our relationship with social media and screens - might be disrupting this delicate balance and potentially driving inflammation throughout our bodies. Dan shares insights from his groundbreaking research on how what we scroll through might literally be changing our biology, and offers practical wisdom on how we can become more mindful of these connections in our daily lives.About Dr. Dan Nicolau:Dr. Dan Nicolau is a polymath researcher whose work spans mathematics, engineering, medicine, and computer science. As a leading voice in neuroimmunology, his research explores how the brain and immune system communicate and how this relationship affects our health from allergies to cancer. His multidisciplinary approach combines rigorous science with profound philosophical insights about what it means to live well in the modern world.Connect with Dr. Dan Nicolau:Email: dan.nicolau@kcl.ac.ukLove,Sarah Ann

The Franciska Show
A Medical Talk About: Vax, Ozempic, SSRi's, Jewish Anxiety, IVF - with Dr. Sharon Stoll

The Franciska Show

Play Episode Listen Later Apr 29, 2025 63:26


Navigating Medicine and Faith: A Conversation with Dr. Sharon Stoll In this episode, Dr. Sharon Stoll discusses her background growing up in a modern Orthodox Jewish community in Philadelphia, her journey to becoming a neuroimmunologist, and her professional experiences working at Yale and now in Philadelphia. The conversation touches on her approach to patient education, especially around COVID-19 and various medications, including GLP-1 agonists like Ozempic and SSRIs for mental health. Dr. Stoll also speaks about her role in JOWMA (Jewish Orthodox Women's Medical Association) and the importance of educating her community on medical issues.    The discussion covers her views on IVF, the ethical considerations of genetic selection, and the interplay of anxiety and genetic predispositions within the Ashkenazi Jewish community. Dr. Stoll shares personal anecdotes and insights into balancing professional and personal life, making this an in-depth and enlightening conversation.   00:00 Introduction and Background 01:19 Professional Journey and Achievements  02:08 Balancing Media and Medicine 03:48 Involvement with Jowma 05:40 Views on Vaccination 14:26 Discussion on SSRIs and Ozempic 28:16 Challenges in the Frum Community  34:38 Debunking Misconceptions About Diabetes 35:07 Educational Gaps and Community Efforts 36:43 Health Education in Schools 39:06 Challenges of Motherhood and Societal Expectations 43:43 Genetic Risks and Mental Health in Ashkenazi Jews 54:38 IVF, Genetic Selection, and Ethical Dilemmas  01:02:34 Concluding Thoughts and Personal Reflections   About Our Guest: Dr. Sharon Stoll is a board-certified neurologist, neuro-immunologist. She currently serves as Director of Neurology at Stoll Medical Group in Philadelphia. For the past 8 years she worked as assistant professor, in the department of neurology at Yale School of Medicine. She completed her neurology residency training at Thomas Jefferson University Hospital in Philadelphia and her Neuroimmunology fellowship at Yale New Haven Hospital. Dr. Stoll played an active role in academic development and continuing medical education. She currently serves on several steering committees and advisory boards. She has been published in numerous peer-reviewed journals and served as Principal Investigator on several clinical trials. Dr. Stoll has received numerous awards, including Top Neurologist, 40 under 40, the Rodney Bell teaching award, and is a national multiple sclerosis society grant recipient. Dr. Stoll is also a medical editor for Medscape and Healthline and previously worked as a medical editor for ABC News. She is also a medical commentator for several national and local news outlets, including ABC, NBC, and CBS News, and has been on a variety of shows, including “The Doctors”. She is an internationally renowned speaker and patient advocate.   https://www.drsharonstoll.com https://www.instagram.com/drsharonstoll/?hl=en https://www.jowma.org  

Inspired to Lead
Neurology, Motherhood & Media; Defying Expectations - with Dr. Sharon Stoll

Inspired to Lead

Play Episode Listen Later Apr 3, 2025 81:03


In this episode of 'Inspire to Lead,' host Talia Mashiach interviews Dr. Sharon Stoll, a board-certified neurologist and neuroimmunologist from Philadelphia. Sharon discusses her upbringing, her unwavering passion for medicine despite societal discouragement, and how she navigated through medical school and residency while managing family life. She shares the pivotal role her supportive husband played in her success and addresses the challenges and triumphs of balancing a demanding career with motherhood. The conversation also delves into the expectations placed on Jewish women in their communities and the importance of pursuing fulfilling careers to maintain overall happiness and effectiveness as both mothers and wives. Sharon's story is an inspiring testament to resilience, determination, and the impact of supportive relationships.   00:00 Introduction to Inspire to Lead Podcast 00:29 Meet Sharon Stoll: A Journey to Medicine 02:38 Balancing Media and Medicine 08:44 Personal Life and Family Dynamics 15:15 Navigating Career and Marriage 37:12 Parenting in Modern Times 39:14 Balancing Career and Family Aspirations 42:43 The Journey to Motherhood 43:16 Navigating Medical School and Motherhood 54:24 Support Systems and Community 01:01:46 Reflections and Advice 01:16:09 Biggest Accomplishments and Lessons Learned     About Dr. Sharon Stoll: Dr. Sharon Stoll is a board-certified neurologist, neuro-immunologist. She currently serves as Director of Neurology at Stoll Medical Group in Philadelphia. For the past 8 years she worked as assistant professor, in the department of neurology at Yale School of Medicine. She completed her neurology residency training at Thomas Jefferson University Hospital in Philadelphia and her Neuroimmunology fellowship at Yale New Haven Hospital. Dr. Stoll played an active role in academic development and continuing medical education. She currently serves on several steering committees and advisory boards. She has been published in numerous peer-reviewed journals and served as Principal Investigator on several clinical trials. Dr. Stoll has received numerous awards, including Top Neurologist, 40 under 40, the Rodney Bell teaching award, and is a national multiple sclerosis society grant recipient. Dr. Stoll is also a medical editor for Medscape and Healthline and previously worked as a medical editor for ABC News. She is also a medical commentator for several national and local news outlets, including ABC, NBC, and CBS News, and has been on a variety of shows, including “The Doctors”. She is an internationally renowned speaker and patient advocate. https://www.drsharonstoll.com   Powered By Roth & Co The JWE For guest suggestions, please email Talia: podcast@thejwe.org

The Neurotransmitters
Neuroimmunology with Dr. Denis Balaban

The Neurotransmitters

Play Episode Listen Later Mar 26, 2025 58:21 Transcription Available


Send us a textDr. Denis Balaban joins us today to talk about a very challenging topic within neurology, neuroimmunology.  Check out our website at www.theneurotransmitters.com to sign up for emails, classes, and quizzes! Would you like to be a guest or suggest a topic? Email us at contact@theneurotransmitters.com Follow our podcast channel on

Beyond Lab Walls | Salk Institute
Irene Gutiérrez | Searching For Answers To Alzheimer's With Neuroimmunology

Beyond Lab Walls | Salk Institute

Play Episode Listen Later Mar 25, 2025 26:25 Transcription Available


Beginning as a spark stirred by rainy day boredom in Galicia, Spain and encouraged by wanting to understand her grandfather's brain tumor, Irene Lopéz Gutiérrez became a neuroscientist. Now, she's a postdoctoral researcher in Professor Susan Kaech's immunology lab—searching for answers about Alzheimer's disease in the exciting new field of neuroimmunology.

RealTalk MS
Bonus: An ACTRIMS Forum Conversation with Dr. Peter Calabresi

RealTalk MS

Play Episode Listen Later Mar 12, 2025 6:22


Just a couple of weeks ago, 1,800 scientists, clinicians, postdoctoral fellows, and medical residents gathered in West Palm Beach, Florida, for the Americas Committee for Treatment and Research in Multiple Sclerosis annual meeting, better known as the ACTRIMS Forum. Dr. Peter Calabresi is the Director of the Division of Neuroimmunology and the Director of the Multiple Sclerosis Center at Johns Hopkins Medicine, focusing on the diagnosis and management of MS. He is the principal investigator on several clinical trials and oversees research projects focused on creating new anti-inflammatory and neuroprotective therapies for MS. At the ACTRIMS Forum, we talked with Dr. Calabresi about updates to the criteria used to diagnose MS, the importance and benefit of identifying biomarkers for MS, and what he sees in MS research today that has him excited. We have a lot to talk about! Are you ready for RealTalk MS??! SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/actrims03 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com RealTalk MS on YouTube https://www.youtube.com/@RealTalkMS Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Bonus Episode Guest: Dr. Peter Calabresi Privacy Policy

STEM-Talk
Episode 179: JP Errico explains how vagus-nerve stimulation reduces inflammation and chronic diseases

STEM-Talk

Play Episode Listen Later Mar 5, 2025 76:43


Today we have JP Errico, a scientist and inventor whose work focuses on neuroimmunology and the many ways it impacts cellular metabolism, inflammation, mental health and how we age. He recently joined IHMC as a Senior Research Scientist. JP is particularly known for his research on vagus-nerve stimulation and is the author of the book, The Vagus-Immune Connection: Harness Your Vagus Nerve to Manage Stress, Prevent Immune Dysregulation, and Avoid Chronic Disease. He also is the co-host of the podcast, The Health Upgrade. JP has more than 250 patents and is the founder of ElectroCore, a company that specializes in neuromodulation and noninvasive vagus-nerve stimulation. He has an undergraduate degree in aeronautical engineering from the Massachusetts Institute of Technology and worked at Lincoln Laboratories. JP also holds graduate degrees in both law and mechanical/materials engineering from Duke University. Show notes: [00:03:08] Tim opens our interview mentioning that as a child JP was focused on both sports and academics. [00:04:50] Tim talks about how hard it is to find quality math and science education today similar to what JP experienced at his high school. [00:05:16] Tim asks JP what it was that led him to pursue an undergraduate degree at MIT. [00:05:53] Tim asks if it was always JP's plan to go into aeronautical engineering. [00:07:22] Tim mentions that as a kid, JP would scour bookstores and libraries for textbooks on physics and quantum mechanics and asks JP if there were any books that particularly inspired him. [00:10:12] Ken mentions that after MIT, JP went to Duke University where he pursued mechanical engineering and also went to law school. Given this workload, Ken asks if JP ever had any free time while studying at Duke. [00:13:26] Tim mentions that while JP was in law school, he got a job at a patent firm. After obtaining his law degree, JP's uncle called and offered JP an opportunity. [00:17:42] Tim explains that JP's career has focused on neuroimmunology, or the study of how the nervous system and immune system interact. Neuroimmunology affects a wide range of health factors including inflammation, mental health and aging. Tim also explains that JP has recently authored a book on neuroimmunology titled “The Vagus Immune Connection: Harness Your Vagus Nerve to Manage Stress, Prevent Immune Dysregulation and Avoid Chronic Disease.” Tim asks JP to touch on the key features of neuroimmunology that people should be aware of. [00:21:59] Tim asks JP to touch on the epigenetic factors regarding neuroimmunology. [00:25:01] Since JP brought up Dr. Kevin Tracey's work, Ken mentions that Kevin was recently interviewed on STEM-Talk episode 172 and encourages listeners to listen to that episode for more context on the vagus nerve and neuroimmunology. [00:25:48] JP talks about how he stumbled upon the idea of how stimulating a nerve may have the same clinical benefit that sometimes occurs as a result of cutting a nerve. [00:28:16] Tim talks about the unintended consequences he observed as surgeon when he cut a patient's vagus nerve. [00:30:50] Ken mentions that another area where JP has had impact with respect to stimulating the vagus nerve is the treatment of asthma and asks JP to talk about his findings in this area. [00:40:10] Tim notes that after JP knew that non-invasive approaches to vagus-nerve stimulation were possible, he went on to optimize a delivery device. These efforts resulted in a device called gamaCore. Tim asks JP to talk about this device and how it works. [00:43:27] Tim asks JP to talk about what it feels like for patients to have their vagus nerve stimulated. [00:44:50] Ken asks if JP thinks that his and others' work in vagus-nerve stimulation inspired the development of similar devices for orthopedic pain, where the device is implanted near the nerve on the knee or other area experiencing pain.

Talk Dizzy To Me
Vestibular Migraine: Surprising Symptoms, Treatment Evolution, and What's Next with Dr. Beh

Talk Dizzy To Me

Play Episode Listen Later Mar 5, 2025 36:19


Can you believe it's been 3 YEARS since we first had a conversation with Dr. Shin Beh about vestibular migraine? Dr. Abbie Ross, PT, NCS, and Dr. Danielle Tolman, PT catch up and discuss some new updates in vestibular migraine treatment approaches. About Dr. BehDr. Beh completed his neurology residency training at the University of Texas Southwestern Medical Center. His fellowship training consisted of: Neuroimmunology & Multiple Sclerosis, Neuro-otology, and Neuro-ophthalmology. His fellowship training was completed at three centers – the University of Texas Southwestern Medical Center, Johns Hopkins University Hospital, and New York University Medical Center. After completion of his fellowship training, he returned to the University of Texas Southwestern Medical Center to to set up its very first Vestibular & Neuro-Visual Disorders Clinic. This Clinic was built to help care for the many people suffering from neurological disorders that caused vertigo, dizziness, and imbalance. Initially, he divided his time between multiple sclerosis and vestibular disorders. After realizing there was a far greater need among people with vestibular disorders, he focused solely on this area, and joined the Headache & Facial Pain Program. Where to find Dr. Beh: https://www.vestibularmd.com/ Hosted by:

Smarter Not Harder
Neuroimmune Chaos & Dysautonomia: Modern Health Mysteries with Dr. Olivia Lesslar | SNH Podcast #112

Smarter Not Harder

Play Episode Listen Later Feb 26, 2025 80:04


In this episode of the Smarter Not Harder Podcast, Dr. Olivia Lesslar discusses how modern challenges impact human survival mechanisms. Dr. Lesslar discusses her unique frameworks like the "Eight Ancient Survival Threats" and the "Network of Threat Detection Systems" to explain how modern syndromes such as dysautonomia and POTS are formed due to evolutionary biology and modern stressors. She delves into optimization strategies for citizen astronauts, stress resilience, and the importance of the mind-body connection.    Join us as we delve into: Demystifying modern health issues with evolutionary biology Ancient survival threats and today's health challenges How psychoneuroimmunology bridges mind and body Dr. Olivia Lesler's life as a global doctor on the move This episode is for you if: You're curious about the nomadic lifestyle of a digital nomad physician. You've been navigating the medical desert and need a fresh perspective. You're eager to learn about ancient survival threats and modern health. You've heard of POTS and want to know about emerging syndromes. You can also find this episode on… YouTube: https://youtu.be/3zRPaImN2IU Find more from Dr. Olivia Lesslar: Website: https://www.drolivialesslar.com/ Instagram: https://www.instagram.com/drolivialesslar/ LinkedIn: https://www.linkedin.com/in/drolivialesslar/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

eanCast: Weekly Neurology
Ep. 133: Autoimmune encephalitis

eanCast: Weekly Neurology

Play Episode Listen Later Feb 2, 2025 31:32


EAN moderator: Maria Pia Giannoccaro (Bologna, Italy)Guests: Alberto Vogrig (Udine, Italy), Maarten Titulaer (Rotterdam, The Netherlands)In this first episode of the Neuroimmunology series, Maria Pia Giannoccaro talks with Alberto Vogrig and Maarten Titulaer about the current approach to diagnosis, acute treatment and long-term management of autoimmune encephalitis.

Neurology Minute
Ten Years of Neurology® Neuroimmunology & Neuroinflammation Decade in Review - Part 2

Neurology Minute

Play Episode Listen Later Jan 30, 2025 3:30


Dr. Justin Abbatemarco and Dr. Josep Dalmau discuss GAD-antibody disorders, providing updates on the diagnosis and treatment of these GAD65-related diseases. Show references: https://www.neurology.org/doi/10.1212/NXI.0000000000200363

Neurology Minute
Ten Years of Neurology® Neuroimmunology & Neuroinflammation Decade in Review - Part 1

Neurology Minute

Play Episode Listen Later Jan 29, 2025 2:05


Dr. Justin Abbatemarco and Dr. Josep Dalmau discuss the evolution of terminology in paraneoplastic disorders and the irruption of immune checkpoint inhibitors. Show references: https://www.neurology.org/doi/10.1212/NXI.0000000000200363 

Neurology® Podcast
Ten Years of Neurology® Neuroimmunology & Neuroinflammation

Neurology® Podcast

Play Episode Listen Later Jan 27, 2025 25:00


Dr. Justin Abbatemarco talks with Dr. Josep Dalmau about the evolution of Neurology: Neuroimmunology & Neuroinflammation over the past decade, and how it has emerged as a leading journal in clinical and translational neuroimmunology. Read the related article in Neurology: Neuroimmunology & Neuroinflammation. Disclosures can be found at Neurology.org.

AAAAI Podcast: Conversations from the World of Allergy
Neuroimmunology – How the Allergic Response is Initiated

AAAAI Podcast: Conversations from the World of Allergy

Play Episode Listen Later Jan 14, 2025 42:57


Caroline Sokol, MD, PhD, FAAAAI, discusses her work looking at how sensory neurons talk to the immune system and are key in initiating the allergic response. She also discusses why the allergic responses likely evolved to respond to toxins rather than worms and parasites. We also discuss the upcoming Discovery program at the AAAAI/WAO Joint Congress and advice for the next generation of scientists.

Immune
Immune 86: Where did the SARS-CoV-2 antibodies go?

Immune

Play Episode Listen Later Nov 26, 2024 65:13


Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Nasal mucsosal macrophages, neuronal maintenance, and pathogen defense (Mucos Immunol) No long lived memory B cells after SARS-CoV-2 mRNA vaccination (Nat Comm) Time stamps by Jolene. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Better Medicine
28. A Better Approach To Multiple Sclerosis and Neurological Autoimmunity with Dr. Erica Rivas

Better Medicine

Play Episode Listen Later Nov 19, 2024 26:43


Multiple Sclerosis is a complex autoimmune condition that is often poorly understood and requires a great deal of expertise to treat it effectively. My guest today, Dr. Erica Rivas does exactly that in her private practice focusing on a more holistic approach to Multiple Sclerosis. We also touch on other Neurological Autoimmune conditions that can affect the brain including Hashimoto's which is often not thought of as a brain condition but rather thyroid condition. Hashimoto's can have direct effects on the nervous system and often causes symptoms in these patients.We discuss:– Her medical background and why she went into Neurology.– What is Multiple Sclerosis and how does she treat it differently from other practitioners?– What are other autoimmune conditions that can affect the brain?– Is there potential for more holistic treatment options for autoimmune brain diseases?– How Hashimoto's affects the brain.– The Biggest challenges she faces with her patient population– Some success stories of patients with her approach.Guest Intro:Dr. Erica Rivas is the medical director of the Multiple Sclerosis and Neurology Institute of Austin. She is an expert in immunological disorders that affect the central nervous system, spinal cord and brain. She completed her fellowship in Multiple Sclerosis and Neuroimmunology at the University of Southern California. She is board-certified in Neurology. She is also the recipient of an educational grant award for the Americas Committee for Treatment and Research in Multiple Sclerosis. She has been named a top doctor in Austin.Connect with Dr. Akhter:Website: www.madinamedicine.comEmail: info@madinamedicine.comYouTube: www.youtube.com/@dromarakhterFacebook: www.facebook.com/madinamedicineaustinInstagram: www.instagram.com/dromarakhterLinkedIn: https://www.linkedin.com/in/dromarakhter/ TikTok: www.tiktok.com/dromarakhter Connect with Dr. RivasWebsite: https://www.msnia.com/Facebook: https://www.facebook.com/multiplesclerosisandneurologyInstagram: https://www.instagram.com/dr_ericarivas

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
785: Investigating Interactions Between the Immune System and Central Nervous System - Dr. Jonathan Kipnis

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later Nov 4, 2024 50:47


Dr. Jonathan (Jony) Kipnis is a BJC Investigator and the Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology at Washington University School of Medicine in St. Louis. He is also Professor of Neurology, Neuroscience, and Neurosurgery and Director of the Brain Immunology and Glia Center there. Jony is a neuroimmunologist. He works at the intersection of the immune system and the nervous system. The brain controls immune system activity, and the immune system affects brain function. The two work together to ensure our survival and well-being. Jony's research is improving our understanding of how they interact when we're healthy and in cases of nervous system damage or disease. When he's not working, Jony loves to read a good book, enjoy a nice glass of wine, cook, and eat delicious food. He particularly has a passion for grilling. He completed his BSc in Biology at Tel Aviv University, and he received his MSc in Neurobiology and PhD in Neuroimmunology from the Weizmann Institute of Science in Israel. Jony worked on the faculty at the University of Virginia for over a decade before joining the faculty at Washington University in St. Louis. He has received numerous awards and honors, including an NIH/NIA MERIT Award, the NIH Director's Pioneer Award, the Harrison Foundation Distinguished Teaching Professorship in Neuroscience, a Gutenberg Research College fellowship from the Johannes Gutenberg University of Mainz, and the Distinguished Research Career Development Award from the University of Virginia. He is also a Member of the National Academy of Medicine. In this interview, Jony shares more about his life and science.

Ask the Expert
1215. Women's Health within Neuroimmunology

Ask the Expert

Play Episode Listen Later Nov 4, 2024 15:00


In this "Ask the Expert" episode titled, "Women's Health within Neuroimmunology," Dr. Sonia Singh joined Krissy Dilger of SRNA to share women's health concerns within the context of neuroimmunology, focusing on issues like fertility and pregnancy for those with rare neuroimmune disorders [00:01:20]. Dr. Singh discussed how certain conditions, such as neuromyelitis optica spectrum disorder (NMOSD) and autoimmune encephalitis, and medications could impact fertility [00:03:45]. They also explored the increased risks of relapse during and after pregnancy and the importance of coordinated care between neurologists and obstetricians [00:07:10]. Dr. Singh emphasized the importance of teamwork during pregnancy to ensure optimal outcomes for both mother and child [00:21:45]. Sonia Kaur Singh, MD is a Neurologist and Assistant Professor of Neurology at Medical University of South Carolina (MUSC), Charleston who specializes in Neuroimmunology. Dr. Singh obtained her medical degree from Kasturba Medical College, Mangalore in Southern India. After graduation, she worked with dementia specialists in India studying dementia in culturally and linguistically diverse populations. She completed her neurology residency at University of Texas Health Science Center Houston (UTHealth Houston) in the Texas Medical Center. During residency, she was involved with innovative learning strategies including a structural competency curriculum and graduated with the prestigious Frank Yatsu Award for Excellence in Clinical Neurology. After residency, she completed a one-year fellowship in Multiple Sclerosis and Neuroimmunology from UTHealth Houston where she was actively involved in medical education and clinical trials. Dr. Singh has a special interest in women's health and cognition in neuroimmune conditions.

RealTalk MS
ECTRIMS Extra: Revisions to the Way MS is Diagnosed with Dr. Peter Calabresi

RealTalk MS

Play Episode Listen Later Sep 28, 2024 9:04


With more than 9,000 MS researchers and clinicians in attendance, the 2024 ECTRIMS meeting in Copenhagen was the largest MS research conference in the world. During the meeting, I had an opportunity to talk with some of the best and brightest minds in MS research and clinical practice. This is your invitation to listen in on my ECTRIMS EXTRA conversation with Dr. Peter Calabresi. Dr. Peter Calabresi is the Director of the Division of Neuroimmunology and the Director of the Multiple Sclerosis Center at Johns Hopkins Medicine. He is the principal investigator on several clinical trials and oversees research projects focused on developing new anti-inflammatory and neuroprotective therapies for MS. At ECTRIMS, Dr. Calabresi co-chaired what was probably the most highly anticipated presentation at this year's conference: the unveiling of updated criteria for diagnosing MS. We have a lot to talk about! Are you ready for RealTalk MS??! SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/ectrims243 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS ECTRIMS Extra Guest: Dr. Peter Calabresi Privacy Policy

Continuum Audio
Therapeutic Approach to Autoimmune Neurologic Disorders With Dr. Tammy Smith

Continuum Audio

Play Episode Listen Later Sep 25, 2024 23:47


Over the past 20 years, more than 50 antibodies have been identified and associated with autoimmune neurologic disorders. Although advances in diagnostic testing have allowed for more rapid diagnosis, the therapeutic approach to these disorders has largely continued to rely on expert opinion, case series, and case reports. In this episode, Allison Weathers, MD, FAAN, speaks with Tammy L. Smith, MD, PhD, an author of the article “Therapeutic Approach to Autoimmune Neurologic Disorders,” in the Continuum® August 2024 Autoimmune Neurology issue. Dr. Weathers is a Continuum® Audio interviewer and associate chief medical information officer at the Cleveland Clinic in Cleveland, Ohio. Dr. Smith is a GRECC investigator and staff neurologist at George E. Wahlen Veteran Affairs Medical Center and an assistant professor of neurology, at the University of Utah in Salt Lake City, Utah. Additional Resources Read the article: Therapeutic Approach to Autoimmune Neurologic Disorders Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Transcript Full episode transcript available here   Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology.  Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME.   Dr Weathers: This is Dr Allison Weathers. Today, I'm interviewing Dr Tammy Smith about her article on therapeutic approach to autoimmune neurologic disorders, which she wrote with Dr Stacey Clardy. This article is a part of the August 2024 Continuum issue on autoimmune neurology. Although, one of the things I love most about being an interviewer for Continuum is getting the opportunity to meet new neurologists and learn all about their areas of expertise, there's something really special when I get the chance to interview and catch up with old colleagues - and today, I'm fortunate to do just that. I had the privilege of working with Dr Smith when she was a resident at Rush, and I'm so excited to be able to speak to her today about her fantastic and really comprehensive article on this very timely topic. Welcome to the podcast, Dr Smith, and please introduce yourself to our audience.   Dr Smith: Hi. Yeah, thank you for inviting me to participate in the podcast and to write this article. So, I'm Tammy Smith. I am a neurologist who practices in Salt Lake City. I primarily work at the Salt Lake City VA Medical Center where I get to treat veterans with all sorts of neurologic diseases. I'm also an assistant professor of neurology at the University of Utah in the division of Neuroimmunology and Autoimmune Neurology, and I serve as a Clinical Consultant for ARUP Laboratories to help improve diagnostic testing for immune-mediated neurologic diseases.   Dr Weathers: Wow. That is a lot of different roles and things that you have on your plate. I want to start, actually, by talking about the article. Again, you cover so much ground (you and Dr Clardy) in this really comprehensive article, but if you had to choose the one most important message - if you wanted our listeners to walk away remembering one key point, what would it be?   Dr Smith: I think the key point I want our listeners to think about is just to use the resources that are available to you. Nobody can have all of these drugs (as we're talking about treatment of autoimmune neurologic diseases in this article) - no one can have all of those drugs memorized, all of the mechanisms of action, all of the approved treatments and off-label treatments, and all of the symptomatic therapies. But that's why resources like the Continuum exist - so that we can provide those resources to clinicians who are busy at that touch of, er, hopefully - or when they open their issue - to get the information they need to make decisions to take good care of their patients.   Dr Weathers: I think that is so reassuring. As I was reading this article, that was, like, one of the things that really struck me is that, you know, thinking about even being a resident and studying for something like the rate exam, you know, how much easier it used to be when there was such a limited number of drugs thinking about the autoimmune diseases or epilepsy, where just the number of drugs has just, kind of, multiplied so manyfold since I was in training, that it's really overwhelming. And I think you make a great (and as I said, a very reassuring) point that we don't have to memorize these, that there are these incredible resources (like Continuum) where it's not any longer about kind of memorization and keeping it in our heads, that it's more about knowing where to look and thinking about what's the right thing for the patient - knowing how to go and get the information is the more important knowledge there. And, actually, thinking about that and moving on, given your expertise, how do you personally approach the management of a patient with an autoimmune neurologic disorder? Again, in the article, you speak about all the different things to keep in mind, both from a therapeutic (really, treatment) standpoint, as well as a symptomatic standpoint - but what is your personal approach?   Dr Smith: My personal approach really involves considering whether the diagnosis of an autoimmune neurologic disorder is correct, first and foremost, and gathering the information to help support that diagnosis - and I think that's something that often gets overlooked in the excitement of a patient coming in with a rare-looking syndrome. Someone sends off diagnostic testing, rules out a few things, decides it's autoimmune, and starts down a pathway and keeps pushing forward. And I understand that inclination on a busy neurology service or in a busy clinic to just decide on one path and move forward, but I'm always questioning the diagnosis, even in the presence of positive antibody results sometimes. If my patient doesn't respond to the treatment that I'm giving them based on their presentation and the antibody results, I reassess and wonder if there's something else going on, are there two syndromes going on, or was that antibody result really not the right answer for some reason. So, I think my approach, really, is to always have a healthy amount of skepticism around the diagnosis, and even when I'm fairly confident in the diagnosis, to continually reassess that patient and their unique response to treatment. And then, also, their unique circumstances - so, everyone will need different symptomatic management, as well as different rehabilitation resources and other resources mobilized to help them maximize their recovery. And so, there's just not a “one size fits all” approach, but always keep talking to the patient, keep re-evaluating, stay curious, and don't be afraid to change paths when things aren't making sense.   Dr Weathers: I think that is incredibly sound, really thoughtful advice. So, I can imagine how incredibly challenging those cases must be when you think you have the right answer, it looks like it's lining up, the antibodies are pointing you in the right direction, and then, they're not responding. What else do you feel is the most challenging aspect of the management of these conditions? Is there some other kind of aspect that you also feel is really challenging in the treatment of these patients?   Dr Smith: Yeah, I think other challenges are really access to state-of-the-art therapies due to financial barriers - I think that's a pretty significant challenge for a lot of these patients, and I think we need to continue to work on advocacy efforts to make sure all patients have access to the medications they need to treat the disorders they are diagnosed with. And it's a real challenge, even when there's FDA-approved therapeutics - a lot of them are quite expensive, and then we end up playing the insurance game, and we learned that AI is automatically denying people's insurance claims, and so, we're battling computers as well as insurance companies. And I think that's a really significant challenge for a lot of these patients. And then, really, just the fact that a lot of immune-mediated neurologic disorders have a long tale. So, we don't treat a patient the same way we do for an infection and expect a dramatic and rapid recovery - a lot of the recovery for these patients happens over months to years. It's a process, and I think it's really important to be counseling patients and caregivers and other providers and educating them about this that we continue to mobilize resources to help our patients long past their inpatient hospitalization and the most dramatic part of their recovery.   Dr Weathers: Again, you raised some really insightful points there. No, I think they're really key. And I think, to your point, that even for some of these patients, that even if we can get over the economic barriers of the medications themselves and get them authorized, get them covered, you're left with, for a lot of patients, all of the other limitations of some of their social determinants of health challenges, right? So, the transportation challenges to even kind of get them to the appointments, and some of the other challenges they face, which makes some of these treatments very, very hard for them to be able to accomplish. So, it is very challenging - I think that's a very important call-out. What do you think is the easiest mistake to make when treating patients with autoimmune neurologic disorders, and how should our listeners avoid it?   Dr Smith: Yeah, that's an excellent question. One of the most common mistakes I see is either overvaluing diagnostic testing or not ordering the appropriate diagnostic testing for the clinical syndrome in any given patient. And where this comes into play, really, is the fact that when we order diagnostic testing in the United States for immune-mediated neurologic disorders, these autoantibody panels are available to us that test for a multitude of autoantibodies all at the same time, and if we don't choose the appropriate test for the clinical syndrome that the patient is there with, we run the risk of getting a positive result for an antibody that's unrelated to the syndrome we're seeing in the patient – and no test is 100% specific (or 100% sensitive, for that matter), but these low-specificity issues when you indiscriminately test really can cloud the clinical picture and delay getting the appropriate diagnosis. And so, I really think that one of the biggest mistakes is seeing maybe a low-positive result for an antibody that does not match the clinical syndrome if you go back to the books and use your resources to figure out if that result is meaningful - overvaluing that antibody result and maybe plowing forward with a treatment plan that involves a long course of immunomodulatory therapy is a pretty significant mistake. And then, on the flip side is that because these panel tests, you order them as a block, and you think that you ordered the right thing - or you think that whoever you asked to order the order for you ordered the right thing – and so often, people say the panel was negative, and they don't look at the individual results of the antibodies that were tested in the panel, and because different antibody panels are designed to test for different clinical phenotypes. I see the error where a clinician thinks that all of the antibodies necessary to test for were tested for and negative, and now they feel like their hands are tied. And so, it's both this overvaluing the diagnostic testing and forgetting to question the testing results if they're not what you expect once you get more clinical data - I think both of those are pretty big mistakes. And continuing, again, always be curious, always recheck results, and don't take laboratory values in an EMR that are in black and white as the stone-cold truth that tells you your answer - you have to stay curious about the patient, their history, their neurologic presentation, their response to treatment over time, and really keep assessing. My other soap box here about diagnostic testing is that, historically, a lot of the antibodies that we test for were called paraneoplastic (and that's because they were some of the first antibodies discovered, so, they were some of the earliest ones that we developed tests for), and clinical reference laboratories continue to offer paraneoplastic panels for historical reasons and because a lot of people think that that's what they want. But, paraneoplastic panels, in and of themselves, are not representative of a specific clinical phenotype - they just diagnose patients who have a high risk of malignancy associated with an antineural antibody. And so, most of the clinical reference labs I know of - certainly at ARUP, we have a notice on our testing page, I know Mayo Clinical Laboratories also has a notice that says, “Paraneoplastic panels are not generally the recommended panel to test for antineural antibodies. Consider ordering the phenotype-specific panel that fits the patient's clinical syndrome”. And I think that's super important – we still have paraneoplastic stuck in our head for historical reasons, and it is almost never the right answer.   Dr Weathers: It's really interesting. At my organization, you know, we actually have had some really thoughtful conversations about, do we really restrict it (you know, as part of lab stewardship efforts) - and, you know, these are expensive, and to your point, they can be frankly, really dangerous, you know, to really send somebody down this wrong path with a lot of surveillance, committing them to immunomodulatory therapies, and take you in completely the wrong direction when, actually, your low test probability was very low. So, I think that is an excellent one to really call out and for people to be very thoughtful of - and the way, again, to avoid it is to be very thoughtful about the panels. And for people, certainly, they are very convenient, but people need to be really aware of what's in them and what they are ordering and how to interpret them. And I love that advice about not just thinking about the wholesale as negative - really, you know, for many of us, they are still coming in as scan documents, you know, click into them, read every line, really understand what those results mean.   Dr Smith: And I would also say that I think people don't realize, but clinical reference laboratories would love for you to reach out when there are questions. So, if you don't understand the diagnostic testing that was performed or result, you pretty much all have hotlines. You can call and reach out to an expert in the testing and ask them some questions, and don't be afraid to reach out to your colleagues who might have more experience. We love hearing from people with questions and helping to direct them to the right testing and help them get the answers that they really want to for their patients.   Dr Weathers: I think that is a great plug. Before you order, preferably, before you send in.   Dr Smith: I do like when I hear from people before mistakes were made. Yes. That's nice.   Dr Weathers: It's a great point.   Dr Smith: When you order these panels, you do run the risk of having these low positive results that may or may not be clinically meaningful. And we do recommend that most of the diagnostic testing be ordered in both serum and CSF. And so, a good example of a mistake that can be made is a very low-positive NMDA-receptor antibody in serum - maybe it was ordered for a patient with cognitive decline or confusion (maybe not under the ideal clinical scenario for ordering), and then it's negative in the CSF. So, an NMDA-receptor positive, negative in the CSF, not the right clinical picture, people can get really jazzed and want to treat an NMDA-receptor encephalitis, that in that case, really isn't meeting diagnostic criteria, and there are excellent diagnostic criteria that have been developed and published for that disorder and for several other autoimmune neurologic disorders, and I think going back to those criteria and really questioning yourself before you start blindly down a path based on a lab result is really important.   Dr Weathers: I think that's excellent advice, too, always keeping that in mind that just because you have gone down this path and gotten that result doesn't mean that you are stuck and committed to it. Always keeping that criteria in mind, always going back, always checking it is really important as well. Moving on from mistakes to kind of an adjacent question, what do you think is the biggest controversy right now when it comes to the treatment of patients with autoimmune neurologic disorders?   Dr Smith: You know, one of the big controversies that I see and I'm concerned about is that we've gotten into a habit of treating the way we've always treated based on expert opinion, and while experts have their opinions based on a lot of experience, they don't take the place of well-designed randomized controlled clinical trials - and in rare diseases (like autoimmune neurologic diseases), it can be really challenging to conduct those trials, especially in the face of people who have a pathway that they always do with their patients. If they have a NMDA-receptor encephalitis patient, they feel very comfortable doing their standard of care with IV steroids and then either plasma exchange or IVIG, and then possibly (and very often), I see following with a B-cell inhibitor, like rituximab, as sort of just a “kitchen-sink” approach to treatment. And while I understand the passion and the desire to make a really sick patient sitting in front of us better as fast as possible, I don't think we have adequate evidence to support that being the “one-size-fits-all kitchen-sick” approach for treatment. And I really am passionate about all clinicians all over the world, supporting randomized controlled clinical trials that are well-designed with the backing of experts in the community, so that when we look at a patient and tell them that we recommend a course of treatment, we're recommending it based on the best quality evidence available, not just what everyone's always done before. I think we can do better than that. And I think there's some controversy in this. Some people think that it doesn't make sense, we already know the answer, but I would say we haven't asked the right question and thoroughly investigated enough. And this is especially important with children, right? We know pediatric patients often don't have well-designed clinical trials to guide their treatments - but in NMDA-receptor encephalitis, many of the patients are children, and I think that they deserve to be involved in well-designed clinical trials in order to support the recommendations that we make for treatment.   Dr Weathers: And in addition to children, think about all of the other patient populations that have traditionally not been well represented in trials, right - pregnant patients, patients of color (historically very underrepresented in trials) - many, many other patient populations that have not been adequately represented.   Dr Smith: Absolutely. Yeah. I think we need to really care about that and face that problem head on and speak to it. We can't just say this is the way we've always done things, so we're going to keep doing it that way. I think we owe it to our patients and ourselves, when we look our patients in the eye, to say that we have good evidence to support the recommendations we're making.   Dr Weathers: I think we have already answered this question in many ways with each of the questions we've already talked about, but is there any other strong arguments that you can make for why it's important for neurology clinicians to read your article?   Dr Smith: Dr Clardy and I spent a lot of time working on this article, trying to put together a piece that will be a resource that people could turn to again and again. I don't think that this article is something that you should read from top to bottom and think that you've absorbed and digested everything, right? So, what we work to do was to really provide a structure and a framework to think about the treatment of immune-mediated neurologic diseases. So, rather than memorizing specific drugs for specific conditions, we developed sort of a space where you could talk about B-cell targeting therapies and the different ways we can target B-cells, we talked about complement inhibitors, neonatal FC receptors, and, really, just at a high level, how these drugs work and how they're targeted, so that going forward in three, four, five years, what I believe we'll know more about each of the individual diseases mediated by antineural antibodies. When we understand what causes that disease, we'll be able to go to a resource like this and choose rationally based on mechanism of action, a drug to treat our patient - even if it's in a patient with such a rare disease that we don't have the luxury of a clinical trial to guide our choices.   Dr Weathers: That's a really excellent point - and I know I've said it a few times, but I think you guys did such a really excellent job at really laying it out in a way that makes it this really comprehensive, really easy-to-use resource at that point of care for providers to be able to do exactly that. Well, I always like to end on a hopeful note, so, this is always my favorite last question – but, what do you think is the next breakthrough coming in the treatment of patients with autoimmune neurologic diseases?   Dr Smith: Yeah, I think in the near future (I certainly hope, at least) that the next breakthrough is going to be in really being able to deliver personalized care based on what we understand about the mechanisms of a patient's rare disease. So, again, right now, I find we're kind of left with the “kitchen-sink” approach because we know so little about the mechanisms that drive each of these unique neurologic diseases and we don't have enough information from clinical trials to inform rational treatment decisions, so we go with these broad approaches - and I really think that in the near future, with work being done by a lot of people (dedicated people over the world) on biomarkers and things that predict either onset of disease or relapse or disease severity or really looking at basic fundamental mechanisms that drive disease, we're going to be able to make more rational choices in the treatment of these patients and mobilize the resources that are expensive, but valuable for the right patient at the right time.   Dr Weathers: That is a very exciting and hopeful future to look towards. Thank you, Dr Smith, for joining me on Continuum Audio. It was wonderful to get to spend this time with you again. Again, today, I've been interviewing Dr Tammy Smith, whose article on therapeutic approach to autoimmune neurologic disorders, written with Dr Stacey Clardy, appears in the most recent issue of Continuum on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you to our listeners for joining today.   Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.

The Brain Podcast
Anti-IgLon5 disease risk is mediated by HLA-DQB1*05 subtypes: when neuroimmunology meets neurodegeneration

The Brain Podcast

Play Episode Listen Later Aug 14, 2024 34:26


Welcome to the 21th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with the first author Dr Selina Yogeshwar of the Brain article entitled: HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease  Dr Yogeshwar offers exciting insight into the genetic mechanisms of a relatively recently discovered disease anti-IgLON5. She also discusses foundational information into how neuroimmunology, neurogenetics and neurodegeneration intersect in this fascinating condition. This exciting episode is not to be missed!  Check out the full article on the Brain website: https://doi.org/10.1093/brain/awae048 This episode was co-hosted by Adam Handel and Chaitra Sathyaprakash,  edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

Ask the Expert
1212. The Role of Physicians and Patients in Legislative Advocacy

Ask the Expert

Play Episode Listen Later Aug 7, 2024 36:03


In this episode of "Ask the Expert," hosted by Krissy Dilger of SRNA, Dr. Shuvro Roy talked about the importance of legislative advocacy in healthcare [00:01:10]. Dr. Roy discussed how physicians can engage in legislative advocacy by sharing their practice stories and providing technical expertise [00:05:05]. He emphasized the crucial role of patients in advocacy, highlighting that their personal stories carry significant weight with legislators [00:07:45]. Dr. Roy also shared examples of successful advocacy efforts, such as telemedicine policy changes and Medicare reforms, contributing to better patient outcomes [00:15:10]. Shuvro Roy, MD is an assistant professor of Neurology at the University of Washington, specializing in Neuroimmunology. He completed his neuroimmunology and neuroinfectious disease fellowship at Johns Hopkins University. He graduated from Medical School at Ohio State University and completed his neurology residency at University of California, Los Angeles. Dr. Roy is actively engaged with a number of projects to improve access to care, healthcare inequality, and patient safety for people with MS and related conditions, with a special interest in neuromyelitis optica and MOG antibody disease. His primary research focus examines how to better leverage health systems to understand and treat neuroimmunologic disorders. He chose to work with people who have MS and rare neuroimmunologic conditions because of the opportunity to build longstanding patient-provider relationships and to help his patients thrive in the face of challenging lifelong conditions.

The Lucky Few
264. Healing and Hope: Navigating Down Syndrome Regression Disorder (w/ Dr. Santoro & Dr. Quinn)

The Lucky Few

Play Episode Listen Later Jul 2, 2024 59:52


Today, we're chatting about the mysterious and challenging world of Down Syndrome Regression Disorder (DSRD). This condition has left many parents searching for answers as they witness profound changes in their children. Joining us are two leading experts, Dr. Jonathan Santoro and Dr. Eileen Quinn, who will share their insights and experiences from the frontlines of diagnosing and treating DSRD. Dr. Santoro serves as the Director of Neuroimmunology and Demyelinating Disorders Program and Director of Research for the Neurologic Institute at Children's Hospital Los Angeles. He also has clinical research expertise in DSRD. Dr. Quinn serves as the Medical Director of the Down Syndrome Clinic at ProMedica Ebeid Children's Hospital in Toledo. Dr. Quinn is also the mother of four perfect daughters, the youngest of whom, Sara, has Down syndrome. They're helping us understand the symptoms, treatment options, and the ongoing fight to understand this perplexing disorder. Friends, we're glad to bring this important conversation to everyone's attention. --- SHOW NOTES Read The Washington Post article featuring Dr. Santoro and Dr. Quinn Regression in Down Syndrome Facebook group Information on Down Syndrome Regression Disorder Facebook Group Additional resources from the National Down Syndrome Society (NDSS) Learn more about DSRD JOIN THE MOVEMENT Join us in celebrating and supporting The Lucky Few Podcast! For just $0.99, $4.99, or $9.99 a month, you can help us continue shouting worth and shifting narratives for people with Down syndrome. Your support makes a difference in our ability to create meaningful content, enable us to cover production costs, and explore additional opportunities to expand our resources. Become an essential part of The Lucky Few movement today!  DISCOUNT CODE Friends, grab your narrative shifting gear over on The Lucky Few Merch Shop and use code PODCAST for 10% off! HELP US SHIFT THE NARRATIVE Interested in partnering with The Lucky Few Podcast as a sponsor? Email hello@theluckyfewpodcast.com for more information! LET'S CHAT Email hello@theluckyfewpodcast.com with your questions and Good News for future episodes. --- Send in a voice message: https://podcasters.spotify.com/pod/show/theluckyfewpod/message Support this podcast: https://podcasters.spotify.com/pod/show/theluckyfewpod/support

Regaining Health and Humanity
Episode 018 - How neuroimmunology and the two-way body-brain connection influence health

Regaining Health and Humanity

Play Episode Listen Later Jul 2, 2024 45:35


Did you know that there is a deep connection between the immune and nervous systems? The vagus nerve links these two vital systems and you can influence this communication link through lifestyle, essential oils, and dietary supplements. Discover how in the latest episode of the Regaining Health & Humanity Podcast. Music from #Uppbeat (free for Creators!): https://uppbeat.io/t/noise-cake/in-my-memory License code: EEKELBJBYMWC9NZL --- Support this podcast: https://podcasters.spotify.com/pod/show/scott-a-johnson/support

Feeling Good Podcast | TEAM-CBT - The New Mood Therapy
401: Ask David: Bipolar, the Dark Side, Changing Behavior

Feeling Good Podcast | TEAM-CBT - The New Mood Therapy

Play Episode Listen Later Jun 17, 2024 44:33


Ask David Bipolar, the Dark Side, Changing Behavior We have lots of great questions today. The answers in the show notes were written prior to the podcast, and the answers in the live podcast as we discussed these questions may differ somewhat or amplify the written materials in these show notes. We love your questions. Remember to send them to David@feelinggood.com. Announcement: Our awesome summer intensive is returning after a long, five years due to the pandemic. It is typically the most outstanding and rewarding TEAM-CBT training of the year, and it will take place again and the wonderful South San Francisco Conference Center from August 8 – 11, 2025. You can attend in person if you register soon, since in-person seating will be strictly limited and only a small number are still available. You can also attend the online, live-streamed version of this program at a substantial discount. The online experience and small group exercises will be similar for the in-person and online participants. Check out the details, including early-bird discounts, at www.cbtintensive.com www.cbtintensive.com Hope to see you there! Warmly, david Today's Questions Alison asks: I have bipolar Disorder and I have had trouble challenging my negative thoughts. I'm suffering. What can I do NAME WITHHELD asks: Can or should a person really and truly accept their dark side? Trainor asks: In TEAM there is a strong emphasis on changing the way you think. But is it sometimes also important to change your behavior, or to make real changes in your life, or to help others who need help changing their circumstances==for example, people who are struggling in poverty.   1. Alison asks: I have bipolar Disorder and I have had trouble challenging my negative thoughts. I'm suffering. What can I do? Hi David, Many years ago I used your book to beat depressive thinking… in the last three years I've been diagnosed with Bipolar Disorder and have found my depressive thinking too difficult to budge with your book. I'm really suffering; any ideas about what I could do? Thank you for your service to humanity. I always recommend your book. David's response Hi Alison, A therapist could help. The new Feeling Great App could help. And tons of free resources at www.feelinggood.com. In addition, can you please give me an example of the negative thoughts you can't budge. Then we can point things out in the podcast and try to figure out why you're getting stuck! I have found that doing cognitive therapy / TEAM-CBT with individuals with Bipolar Disorder is exceptionally helpful during the depressed (not manic) phase, and works pretty much the same way as with anyone who's feeling down. Best, david   2. NAME WITHHELD asks: Can or should a person really and truly accept their dark side? Hello David, My name is NAME WITHHELD and I am doing my PhD degree in Neuroimmunology in LOCATION WITHHELD. I had come across your book feeling good and your podcasts by one of my therapists - they have had an immense impact on my way of thinking. I really love disarming and using “I feel” statements to connect! I had also realized that by finding some genuine truth in a person's belief even if it sounds ridiculous, I would automatically develop certain level of respect for that person! I really love that! I feel really happy that I can respect a person even without accepting his/her beliefs!! I am now working on my distortions. I really love working on my mind that way. Anyway, I have wanted to ask you if a person CAN accept his/her dark side? I seemed to have loathed myself for quite a long time and couldn't stand living alone without a partner or a person around. I hated myself for disrespecting my mother whilst growing up. But, sometime during Dec last year, I had had an epiphany of why things happened the way they did and somehow, I learnt that the reason why I had disrespected my mother was because my father, after their separation, kept filling my mind about how wrong my mother was for breaking up the family and I believed him because I had a good rapport with him, than I had with my mother. Also, my mother was very awkward in building a relationship with me and I had misconstrued that with her indifference towards me. After that, I stopped hurting myself over it because I had learnt to empathize with myself then. I sobbed profusely that day. Is it really possible to truly accept yourself? I feel at ease a lot more these days than I used to before. But I also have to battle my distortions too on a regular basis! Please help me out here! Thank you so much for everything that you have done!! I really love your work!! Regards, NAME WITHHELD David's reply Thanks so much. I hid your name and location, and hope that's okay, and we WILL include your excellent question on our upcoming podcast. My brief reply is that all human beings have a “dark side,” and that we are far better off accepting it, as opposed to denying it and seeing ourselves as “totally good,” because then we might see others as “totally bad,” and feel morally superior. This dynamic is the cause of wars and a great deal pf hatred and suffering.   3. Trainor asks: In TEAM there is a strong emphasis on changing the way you think. But is it sometimes also important to change your behavior, or to make real changes in your life, or to help others who need help changing their circumstances--for example, people who are struggling in poverty. Hey David! I have asked several questions over the years (I asked about A.I. which I much enjoyed the episode on that!), so feel free to ignore this email if you feel I've overburdened you guys. Anyway, I had a question about changing thoughts versus circumstances. You often say that our thoughts create all of our emotional and interpersonal realities. I thought maybe a better or more nuanced definition would be to also mention that events CAN change our feelings but they do so through changing our thoughts. I have heard Matt May mention this idea in some circumstances as the "low road to recovery." Where you actually get the thing you think you need and as a result feel better. However, I thought about certain situations where changing the circumstance could also be a valid solution to an individual's problems. Take someone living in poverty, I am certain that CBT could help this person change their emotions around the experience of living in poverty. But would bringing the individual out of poverty be considered a "low road to recovery"? Or could we say that bringing someone out of poverty is also a valid way of changing their emotional distress? Like sort of how therapists use both exposure and cognitive techniques to quell phobias or certain anxieties. I personally like this definition because it includes the ability to change your circumstances as a method to change your thinking, without it being the only method. It also makes sense in a world where people want to make changes in society (giving women the right to vote, ending child labor) and create environments that foster positive thinking. I think so much focus on the cognition (while fundamentally true) makes it feel like people should focus exclusively on changing the way they think about a situation. When, in reality, it seems like we can both change our circumstances and thinking simultaneously to make our lives better. Anyway, just wanted to know what you thought about this idea. Thanks for everything you do, Trainor Peters P.S. I have nearly completed my first year of my psychology undergrad to become a counselor. In great part to you and all the wonderful people on your podcast. So, thank you! David's reply. Thanks, Trainor, I will add this excellent question to our Ask David list, if that's okay, and discuss with Matt and Rhonda on a podcast. My hospital in Philadelphia was located in an inner-city neighborhood, and many (perhaps most) of our patients have very limited resources. Some were homeless, and many had not completed the 5th grade. This gave me abundant opportunities to work with people with “real” problems in addition to their distorted perceptions. In addition, I have always emphasized that sometimes you need to change the way you behave in the “real” world in addition to changing the way you think about it. We'll give these topics a deeper dive on the live podcast discussion. And, best of luck in your ongoing training! Once you are in a graduate program, you will be eligible, if interested, to join one of our two free weekly TEAM-CBT training groups, which are both virtual. Warmly, david Thanks for listening today! Rhonda and David Special Announcement Attend the legendary Summer Intensive Featuring Drs. David Burns and Jill Levitt August 8 - 11. 2024 Learn Advanced TEAM-CBT skills Heal yourself, heal your patients First Intensive in 5 long years. It will knock your socks off! Limited Seating--Act Fast! Click for registration / more information! Sadly, this workshop is a training program which will be limited to therapists and mental health professionals and graduate students in a mental health field  Apologies, but therapists have complained when non-therapists have attended our continuing education training programs. This is partly because of the intimate nature of the small group exercises and the personal work the therapists may do during the workshop. Certified coaches and counselors are welcome to attend. But there's some good news, too! The Feeling Great App is now available in both app stores (IOS and Android) and is for therapists and the general public, and you can take a ride for free! Check it out!

The ECTRIMS Podcast
The Impact of Ageing on MS

The ECTRIMS Podcast

Play Episode Listen Later Jun 5, 2024 28:52


While multiple sclerosis (MS) has been traditionally described as a disease of young adults, the significant improvements in treatments over the past few decades has meant that researchers and clinicians are now increasingly handling questions related to the impact of ageing.  In this episode, host Brett Drummond of MSTranslate talks with Anneke Van Der Walt, Director of MS and Neuroimmunology and Neuro-ophthalmology at Alfred Health in Melbourne, Australia and lead of the MS and Neuro-ophthalmology Research Group at the School of Translational Medicine, Monash University; and Professor Frederik Barkhof, Chair of Neuroradiology, Brain Repair & Rehabilitation at University College London's Queen Square Institute of Neurology and Professor in Neuroradiology at the Department of Radiology & Nuclear Medicine at VUmc in Amsterdam, on the key takeaways from a recent international workshop on ageing.

Ask the Expert
1209. What is ULTOMIRIS?

Ask the Expert

Play Episode Listen Later May 31, 2024 18:56


Dr. Michael Levy joined Dr. GG deFiebre of SRNA for the “Ask the Expert” podcast episode titled "What is ULTOMIRIS?" Dr. Levy explained that ravulizumab (ULTOMIRIS) is the newest FDA-approved medication for neuromyelitis optica spectrum disorder (NMOSD), offering a longer dosing interval compared to eculizumab (Soliris) [00:01:08]. Dr. Levy discussed the mechanism of ULTOMIRIS, which blocks the complement system to prevent relapses in NMOSD and highlighted the importance of vaccinations and possible antibiotic use to prevent infections while on this medication [00:02:48]. He also noted that ULTOMIRIS is more affordable than Soliris and emphasized the need for insurance coverage to make it accessible to patients [00:16:39]. Michael Levy, MD, PhD is an Associate Professor of Neurology at Massachusetts General Hospital and Research Director of the Division of Neuroimmunology & Neuroinfectious Disease. He completed the MD/PhD program at Baylor College of Medicine with a focus on neuroscience. In 2009, Dr. Levy was appointed to the faculty as Assistant Professor at Johns Hopkins where he started the Neuromyelitis Optica Clinic and Research Laboratory and in 2019 he moved to the Massachusetts General Hospital and Harvard Medical School to develop the research program in neuroimmunology. Clinically, Dr. Levy specializes in taking care of patients with rare neuroimmunological diseases including neuromyelitis optica, transverse myelitis, MOG antibody disease, acute disseminated encephalomyelitis and optic neuritis. In addition to neuroimmunology clinics, Dr. Levy has a special interest in patients with superficial siderosis of the central nervous system. Dr. Levy is the principal investigator on several clinical studies and drug trials for all of these conditions. In the laboratory, Dr. Levy's research focuses on the development of animal models of neuromyelitis optica and transverse myelitis with the goal of tolerization as a sustainable long-term treatment.

Biohacking Superhuman Performance
Episode #236: Dr. Olivia Lesslar on Emotional Autophagy: Clearing Mental Burdens for Physical Healing

Biohacking Superhuman Performance

Play Episode Listen Later May 21, 2024 74:55


How can our mindset, emotions, and life experiences impact our physical health and immune function in ways that are often overlooked by conventional medicine?   We're diving right into this topic for today's conversation. Dr. Olivia Lesslar joins the podcast to discuss the field of psycho neuro immunology (PNI) and its impact on health and well-being. She explains the complexity of PNI and how everything in the body is interconnected. Dr. Lesslar emphasizes the power of belief and mindset in influencing health outcomes and highlights the importance of addressing emotions and attitudes in patient care.    We also discuss the role of compassion in medicine and the need to treat the whole person. Our conversation explores the subjectivity of pain, the impact of hypochondria and the nocebo effect, and the potential for small changes to make a significant difference in health.    Dr Olivia works with innovative clinics and organizations worldwide. Her coordinating clinic is Cingulum Health - a neuro center founded by renowned neurosurgeon Professor Charles Teo.   She is an Adjunct Senior Lecturer with The National Centre for Neuroimmunology and Emerging Diseases.   Thank you to our sponsors for making this episode possible: Neurohacker Collective: Visit neurohacker.com/nathalie and use code NATHALIE Fatty15: Visit http://fatty15.com/NAT and use promo code NAT to save. Inside Tracker: Use NIDDAM to save 10% at https://www.insidetracker.com   Find more from Olivia Lesslar: Website: https://www.drolivialesslar.com/  Instagram: https://www.instagram.com/drolivialesslar/  Facebook: https://www.facebook.com/drolivialesslar  Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat's Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  02:13 Psycho Neuro Immunology (PNI) 03:35 The Complexity of PNI 06:16 The Power of Belief and Mindset 10:47 Anxiety and the Importance of Letting Go 17:15 Navigating Hypochondria and Nocebo Effect 20:50 The Power of Small Changes 26:09 The Role of Transient Receptor Potential Ion Channels 39:02 Immunotherapy and Emotions 40:20 The Impact of Stress on Allergies 41:57 The Neglect of Lifestyle Changes in Medicine 50:42 Curiosity and Open-Mindedness in Medicine 53:23 Reframing Threats and Flooding the Body with Safety Signals 01:02:43 The Biology of Belief and Curiosity Key Takeaways: Psycho neuro immunology (PNI) is a field that explores the interconnectedness of psychology, the nervous system, the immune system, and hormones. Belief and mindset have a significant impact on health outcomes and can influence the body's physiological responses. Emotions and attitudes play a crucial role in overall well-being and should be addressed in patient care.  

TLC Sessions - Living with Long Covid
Episode 74: Nancy Klimas M.D. - Neuroimmunology

TLC Sessions - Living with Long Covid

Play Episode Listen Later Apr 19, 2024 63:59


Dr Nancy Klimas, Director of the Institute for Neuro-Immune Medicine, Nova Southeastern University, is an immunologist internationally renowned for her work in multi-symptom illnesses.  In this week's episode she explains her work, from HIV through ME/CFS and Gulf War Syndrome, that has led to her having insight and an amazing team to channel efforts into Long Covid research and treatment.  In an insightful overview she describes her work in understanding the mechanisms (viral persistence, viral reactivation), impacts of (MCAS, cell dysfunction, T-cell dysregulation) and potential alleviation of the disease.  She has been involved in studies looking at clinical therapeutics such as LDN and has seen remarkable results with the use of MABs which she is hoping to replicate in a larger clinical trial in the coming weeks.Living with Long Covid? How was your week?Website - https://www.tlcsessions.net/Twitter - @SessionsTlc https://twitter.com/sessionstlcInsta - @tlcsessions https://www.instagram.com/tlcsessions

PeerVoice Clinical Pharmacology Audio
Ali Aamer Habib, MD - Neuroimmunology Matters: A Specific Review of Emerging Targeted Strategies for Generalised Myasthenia Gravis

PeerVoice Clinical Pharmacology Audio

Play Episode Listen Later Mar 26, 2024 25:13


Ali Aamer Habib, MD - Neuroimmunology Matters: A Specific Review of Emerging Targeted Strategies for Generalised Myasthenia Gravis

PeerVoice Internal Medicine Audio
Ali Aamer Habib, MD - Neuroimmunology Matters: A Specific Review of Emerging Targeted Strategies for Generalised Myasthenia Gravis

PeerVoice Internal Medicine Audio

Play Episode Listen Later Mar 26, 2024 25:13


Ali Aamer Habib, MD - Neuroimmunology Matters: A Specific Review of Emerging Targeted Strategies for Generalised Myasthenia Gravis

RealTalk MS
Episode 341: How MS Can Impact Vision with Dr. Shiv Saidha

RealTalk MS

Play Episode Listen Later Mar 11, 2024 31:17


Vision impairment is a key symptom of multiple sclerosis. In fact, many people experience optic neuritis as the very first sign of MS. People living with MS may also experience other vision-related issues including internuclear ophthalmoplegia, diplopia, nystagmus, oscillopsia, and reading fatigue.  Dr. Shiv Saidha joins me as we take a deep dive into strategies for navigating MS-related vision issues while managing and optimizing your vision. Dr. Saidha is a professor of neurology in the Division of Neuroimmunology and Neurological Infections at Johns Hopkins Medicine. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: We're taking a deep dive into managing MS-related vision issues  :22 Doctor Shiv Saidha discusses how to best manage MS-related vision issues  1:17 Share this episode  29:44 Have you downloaded the free RealTalk MS app?  30:05 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/341 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 341 Guest: Dr. Shiv Saidha Privacy Policy

Vitamin Katie
#100: How This Celebrity Doctor Optimizes Health, Dr. Olivia Lesslar

Vitamin Katie

Play Episode Listen Later Mar 4, 2024 47:45


Want to optimize your health but don't know where to begin? Dr. Lesslar discusses some simple, free, low hanging fruit that you can get started on right away to achieve optimal health and wellness, no matter how complex your symptoms or disease process might be. Dr Olivia Ly Lesslar Bachelor of Medicine, Bachelor of Surgery (MBBS), Australia Bachelor of International Relations (BIR), Australia Postgrad Certs in Skin Cancer Medicine, Clinical Nutrition Management and Dermatology CURRENT CAREER APPOINTMENTS Atlus, Queensland, Australia - Chief Medical Officer Atlus  CFS Health Program, Queensland, Australia - Resident Medical Consultant CFS Health  Cingulum Health, Sydney, NSW, Australia - Medical Director of Functional and Longevity Medicine Cingulum Health  Everest Health, Washington D.C., USA - Special Advisor Everest Health Partners  LifeSpan Medicine, Los Angeles, CA, USA - Associate - LifeSpan medicine  Queensland Allergy Clinic, Queensland, Australia - Visiting Expert QLD Allergy  Scott Laidler Fitness, London, UK - Medical Director Scott Laidler Fitness  Sens.ai, Montreal, Canada - Science Director Sens.ai Super Young, Melbourne, VIC, Australia - Medical Director Super Young  Wellgevity, London, UK - Associate Wellgevity London  ADVISORY BOARDS / CONSULTANT ROLES / ACADEMIC APPOINTMENTS Bioharmonize, Helsinki, Finland - Co-founder Bioharmonize  British College of Functional Medicine, London, UK - Trustee, Research and Events Lead BCFM  The Darbon Institute, Sydney, NSW, Australia - Clinical Advisor Darbon Institute  Egoo Health, Copenhagen, Denmark - Medical Advisor Egoo.health  Holistic Health Institute, Sydney, NSW, Australia - Consultant Expert Unstress Health Approach  Human Regenerator, London, UK - Clinical Consultant Human Regenerator  Liber8, Denver, CO, USA - Medical Advisor Liber8  The Naked Pharmacy, London, UK - Medical Advisor The Naked Pharmacy  The National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Queensland, Australia - Adjunct Senior Lecturer NCNED  National University of Singapore Medicine International Council, Singapore - Advisory Council to the Dean of Medicine NIC  Oxford Healthspan, Oxford, UK - Clinical Advisor Oxford Healthspan  Simplr Health, Sydney, NSW, Australia - Clinical Advisor Simplr Health  I would love to connect! Instagram: https://www.instagram.com/vitamin.katie/ Website: https://katie-reines.squarespace.com/ Email: k.reines1@gmail.com Looking for personalized nutrition recommendations and accountability? Click here to apply for a free initial consultation with me: https://form.jotform.com/193528759357172 Use discount code 'VITAMINKATIE40' to save $40 on your NutriSense Continuous Glucose Monitor: https://www.nutrisense.io/ Natural fertility tracker with 99.4% accuracy at determining fertile vs non fertile days with code 'DAYSYUS+485' https://join.daysy.me/go.cgi?pid=485&... Complement Essentials use code VITAMINKATIE: https://lovecomplement.com/products/complement-essential-vegan-multivitamin LyfeFuel Recovery Shake & Adaptogenic Supplements, code VITAMINKATIE (every purchase plants trees) : https://lyfefuel.com/ Hawaiian Ceremonial Cacao from Kokoleka Collective, use discount code 'KATIELOVE' : https://www.kokolekacollective.com/

MS Living Well: Key Info from Multiple Sclerosis Experts

Sex hormones, such as estrogens and testosterone, affect each individual's journey living with multiple sclerosis. While both genders face equal MS risk before puberty and after menopause, women experience up to three times higher risk during their reproductive years. Pregnancy generally brings less relapses, potentially attributed to high estriol levels. However, navigating treatment decisions well while trying to conceive and after delivery requires finesse and expertise. Equip yourself with the latest women's health info regarding MS, covering topics from birth control and fertility treatments to menopause and osteoporosis. Testosterone has important anti-inflammatory and neuroprotective benefits in multiple sclerosis.  Nevertheless, men are at higher risk for disability progression then women. Declining testosterone levels over time (called andropause) and Y chromosome genes may tilt the scales towards disability. Listen to current testosterone research including potential remyelination benefits. Barry Singer MD, Director of The MS Center for Innovations in Care, interviews: Maria Houtchens MD, founding director of the Women's Health Program at the Brigham MS Center and Associate Professor of Harvard Medical School in Boston, USA Jorge Correale MD, Head of Neuroimmunology and Demyelinating Diseases at the Dr. Raúl Carrea Institute of Neurological Research in Buenos Aires, Argentina  

Emerge Australia Imagine Podcast Series
Episode 16 – Dr Alain Moreau

Emerge Australia Imagine Podcast Series

Play Episode Listen Later Jan 25, 2024 56:04


In this podcast Anne Wilson, CEO Emerge Australia, is in a fascinating conversation with Dr Alain Moreau, hot on the heels of his enlightening November keynote address at The National Centre for Neuroimmunology and Emerging Diseases, ME/CFS and Long COVID International Conference in northern New South Wales. Dr Moreau is a Full Professor in the […]

Emerge Australia Imagine Podcast Series
Episode 15 – Dr David Systrom

Emerge Australia Imagine Podcast Series

Play Episode Listen Later Jan 18, 2024 58:42


In this podcast, Anne Wilson, CEO Emerge Australia is in enlightening discussions with Dr David Systrom, who recently presented a most absorbing keynote address at The National Centre for Neuroimmunology and Emerging Diseases, ME/CFS and Long COVID International Conference in northern New South Wales, here in Australia. Dr Systrom is a member of the Brigham […]

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
740: Targeting Complex Sugars on Cell Surfaces to Treat Multiple Sclerosis and Cancer - Dr. Michael Demetriou

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later Dec 25, 2023 41:13


Dr. Michael Demetriou is Director of the National Multiple Sclerosis Society Designated Comprehensive Care Clinic, Professor of Neurology, and Chief of the Division of Multiple Sclerosis and Neuroimmunology at the University of California, Irvine (UCI) School of Medicine. In his research, Mike studies the biological roles of complex sugars called glycans. Glycans are mostly found outside of cells and on cell surfaces. They form a dense forest around the surface of cells and can interact with other proteins to regulate cellular function through interactions with other cell surface proteins. Mike's lab is interested in how these cell surface glycans influence biology and disease, particularly in autoimmune diseases like multiple sclerosis (MS) and in diseases like cancer where there are commonly abnormalities in these glycans. Mike is also a big fan of the Toronto Maple Leafs hockey team. While he doesn't play hockey himself anymore, he loves watching professional hockey games and seeing the Maple Leafs play whenever they are in town. He was awarded his MD and his PhD in molecular genetics from the University of Toronto. Mike completed his residency in Neurology at the University of Toronto as well and completed his postdoctoral fellowship at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto. He has received a variety of awards and honors in his career, including being named a Fellow of the Royal College of Physicians and Surgeons in Canada. In addition, he has received UCI's College of Medicine Committee on Research Award, the Health Science Partners Research Award, the Academic Senate Distinguished Service Award, and the Dr. S. Van Den Noort Research Award for Junior Faculty. In our interview, Mike shares more about his life and science.

Mother Up
Neurodevelopment and Brain Health: Dr. Sharon Stoll on Screen Time, Mom Guilt, and Postpartum Challenges

Mother Up

Play Episode Listen Later Dec 4, 2023 50:34


Kacie and Gianna are joined by board-certified neurologist Dr. Sharon Stoll to discuss neurodevelopment in children, the effects of screen time and contact sports, her experience with postpartum depression and advice for moms going through it and navigating mom guilt (and when sometimes it's a good thing!). Dr. Stoll completed her fellowship training in Neuroimmunology at Yale School of Medicine, where she also served as an assistant professor for over 8 years. Her contributions to the field have earned her numerous awards and she is a well-known medical commentator for national news outlets such as ABC, CBS, and Fox News. Beyond her clinical work, Dr. Stoll is a published author in numerous peer-reviewed journals, an internationally renowned speaker and a dedicated patient advocate. Connect with Dr. Sharon Stoll: www.instagram.com/DrSharonStoll www.DrSharonStoll.com www.twitter.com/DrSharonStoll Stoll Medical Group Connect with Kacie & Gianna: ⁠⁠⁠⁠www.motheruppod.com⁠⁠⁠⁠ ⁠⁠⁠⁠www.instagram.com/motheruppod⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/@motheruppod⁠⁠⁠⁠ View full show notes at ⁠⁠⁠www.motheruppod.com⁠

The Neurophilia Podcast
A Conversation with Dr. Suma Shah and Dr. Alissa Willis: The Subspecialty of Neuroimmunology and MS

The Neurophilia Podcast

Play Episode Play 45 sec Highlight Listen Later Oct 9, 2023 51:39


In this episode of the Neurophilia Podcast, we sat down with two experts in the field of neuroimmunology, Drs. Suma Shah and Alissa Willis, and discuss their journeys into medicine as well as the unique privileges and challenges of a neuroimmunologist. Also, we highlighted the gender gaps in academic neurology and shared ways to promote women in leadership. If you want to learn more about neuroimmunology, women in academic neurology, or Drs. Shah and Willis' go-to comfort meals, make sure you listen to the full episode and leave us a review!Dr. Suma Shah is a fellowship-trained MS Specialist and Associate Professor of Neurology at Duke University School of Medicine. She serves as the Co-Associate Director of Clinical Care, MSCoE East, the Regional Director of the Regional MS Center of Excellence for the Durham VA, and the Program Director of the Duke Adult Neurology Residency Program.  Dr. Shah is actively involved in Duke Neurology's educational mission teaching and mentoring multiple learners and trainees.  She has been honored with teaching awards including the Golden Apple Teaching Award (2015), the E Wayne Massey Residency Teaching Award (2017), and the annual Duke Neurology Faculty Teaching Award (2021, 2022).Dr. Mary Alissa Willis is a clinician-educator passionate about multiple sclerosis and making neurology relevant and interesting for all trainees.  She has received numerous teaching awards including Alpha Omega Alpha Teacher of the Year and the AB Baker teacher recognition award from the AAN. After serving as Associate Residency Program Director and Medical Director of the Mellen Center for Multiple Sclerosis at Cleveland Clinic, Dr. Willis returned home to Mississippi as chair of the department of neurology at the University of Mississippi Medical Center.Follow the Neurophilia Podcast on Twitter and Instagram @NeurophiliaPodFollow Dr. Suma Shah on Twitter @sumadshahFollow Dr. Alissa Willis on Twitter @myelinMDFollow Dr. Nupur Goel on Twitter @mdgoelsFollow Dr. Blake Buletko on Twitter @blakebuletkoSupport the show

Exposing Mold
Ion Channelopathy: The Important Scientific Clue in CFS with Prof. Sonya Marshall-Gradisnik

Exposing Mold

Play Episode Play 45 sec Highlight Listen Later Jul 31, 2023 45:03


Professor Sonya Marshall-Gradisnik is Director of the National Centre for Neuroimmunology and Emerging Diseases (NCNED), Griffith University. She is an immunologist and recognized as the world leader in natural killer (NK) cell and ion channel dysfunction research for the identification of the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long Haul COVID-19 through her pioneering technique of electrophysiology patch clamp. Her discoveries are contributing directly to the development of a screening/diagnostic test and improved clinical guidelines and effective treatments for ME/CFS, including pharmacotherapeutics and drug repurposing. Professor Marshall-Gradisnik has achieved sustained success as an independent research leader through successful competitive grants, such as NHMRC and ME Research UK, and numerous philanthropic national and international grants of more than $15 million for over ten years. She has published over 115 scientific publications in the field of ME/CFS, graduated over 45 post graduate students and is an advisor to national and international agencies. Dr. Gradisnik is joined with her colleague Kay Schwarz and research fellow, Natalie Eaton-Fitch, PhD.  Need help navigating your mold injury without breaking the bank? Join our education group: exposingmold.org/membership Exposing Mold is a nonprofit! Donate here: https://www.flipcause.com/secure/cause_pdetails/MTY0OTg0Medical Disclaimer:This podcast is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician. Always seek the advice of your doctor or other qualified health provider regarding a medical condition.Support the showFind us on Linktree, Facebook, Instagram, Twitter, TikTok and Youtube

DKBmed Radio
Overcoming Barriers to MS Care

DKBmed Radio

Play Episode Listen Later Jul 19, 2023 23:08


Too many individuals with MS are not receiving access to the most effective care. Why? What's behind these disparities? And what can individual clinicians do to help remove the barriers that prevent equitable care for all patients?Join us, as Dr. Dorlan Kimbrough, from the division of Neurology, Multiple Sclerosis, and Neuroimmunology at the Duke University School of Medicine, discusses these topics, in this issue of eMultipleSclerosis Review. Take our post-test to claim CME credits.Read this podcast's companion newsletter here. Hosted on Acast. See acast.com/privacy for more information.

The WellBe Podcast (getwellbe)
Donna Jackson Nakazawa on the Link Between Stress, Emotion, and Immunity

The WellBe Podcast (getwellbe)

Play Episode Listen Later May 8, 2023 65:13


Donna Jackson Nakazawa is an acclaimed science writer who loved to tackle complex problems with big implications for people's everyday life and health. In this interview, she explains one of the biggest and most exciting of these topics: the field of psycho neuroimmunology, of the interplay between our brain, our stress response, and our immune system. Listen to the interview to learn how difficult childhood events shape our stress response for life, why the brain has its own immune system and what this has to do with our body's immune system, why emotional or social threats can have a serious impact on physical health, how early childhood experiences can contribute to autoimmune disease later in life, and much more. Join the conversation at the written version of the article here: https://getwellbe.com/psycho-neuroimmunology-donna-jackson-nakazawa

Immune
Immune 62: Every cell is an immune cell with D'Broski Herbert

Immune

Play Episode Listen Later Dec 2, 2022 83:43


D'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guests D'Broski Herbert Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immunology of helminth infections (Ann Rev Immunology) Neuroimmune regulatory networks (J Leuk Biol) Every cell is an immune cell (Immunity) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv