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Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs: https://membership.metabolicinitiative.comIn today's journal club episode, co-hosts of The Metabolic Link, Dr. Angela Poff and Dr. Dominic D'Agostino, unpack the startling rise of non-alcoholic fatty liver disease (NAFLD)—a silent epidemic affecting millions worldwide. Tune in as they break down groundbreaking new research revealing how NAFLD isn't just impacting adults, but alarmingly, children and adolescents too.You'll learn about the latest updates in terminology, such as Metabolic Dysfunction Associated Steatohepatitis (MASH) and Metabolic Dysfunction Associated Steatotic Fatty Liver Disease (MASLD), highlighting a critical connection to underlying metabolic dysfunction. Plus, discover exciting dietary strategies—like therapeutic carbohydrate restriction—that hold potential not just to prevent, but to actually reverse liver fat accumulation.If you've ever wondered how your diet and lifestyle choices directly shape your metabolic health, this episode delivers practical insights and actionable information straight from cutting-edge science. Don't miss this deep dive into the latest science on NAFLD—and how simple shifts today could dramatically improve your metabolic health tomorrow.Special thanks to the sponsors of this episode:Genova Connect – Get 15% off any test kit with code METABOLICLINK hereMaui Nui Venison: Gain access to a limited collection of our favorite Maui Nui products hereiRestore: Use code METABOLICLINK for exclusive discounts on the iRestore Illumina Face Mask here Puori – Get 20% off supplements with code METABOLICLINK hereRead the papers discussed here: https://pubmed.ncbi.nlm.nih.gov/38521116/ https://pubmed.ncbi.nlm.nih.gov/38914224/https://pubmed.ncbi.nlm.nih.gov/38771552/https://pubmed.ncbi.nlm.nih.gov/38723301/ In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here. In this journal club episode, host Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D'Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping cancer metabolism through lysine beta-hydroxybutylaration.From the clinical implications of these findings to the potential of ketone supplementation, this episode is packed with insights for researchers, clinicians, and health enthusiasts. Don't miss the opportunity to learn how these discoveries could shape the future of precision medicine.
Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here.In this journal club episode of The Metabolic Link, we explore the cutting-edge "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain's energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.We discuss how this groundbreaking research links bipolar disorder to epilepsy and how therapeutic ketosis—through diet or supplementation—might restore energy balance, reduce manic episodes, and complement traditional medications.With the potential to reshape psychiatric treatment, you won't want to miss this paper or journal club episode! Read the full paper here: https://www.nature.com/articles/s41380-024-02431-wSpecial thanks to the sponsors of this episode:Genova Connect - Receive 15% off any of their tests with code METABOLICLINK hereFatty15 - Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK hereNed - Get 15% off Ned products with code METABOLICLINK hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at https://gdx.net/themetaboliclinkAs mentioned in the introduction, you can watch the free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this episode of The Metabolic Link, Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field recap Metabolic Health Summit 2024, the world's leading medical and scientific conference on metabolic health. Listen to this episode to get an inside look at the top scientific highlights and surprising moments from the perspective of the hosts who made it happen.Want to learn about all the cutting-edge research and scientific insights on metabolic health and therapy that you won't find anywhere else? We recorded the entirety of Metabolic Health Summit 2024 and you can still watch the replay, but the window is closing very soon! Click here to secure your access before time runs out.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this episode, our co-hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field discuss two recent scientific papers on the metabolic effects of allulose and how blocking fructose intake may help fight cancer.The first paper examines how allulose consumption influences metabolic factors like appetite, blood sugar, and insulin sensitivity through the release of key gut hormones and effects on carbohydrate digestion and metabolism.The second paper reviews multiple lines of evidence linking fructose metabolism to driving cancer progression. High fructose intake may directly supply tumors with fuel and biomolecular building blocks to grow while also creating an obesity and diabetic state that triggers cancer development. The paper proposes dietary fructose restriction as a potential anti-cancer intervention.Overall, the episode illuminates cutting-edge research on sugar, diet and disease. With that said, our hosts emphasize the need for further study. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this episode, our co-hosts Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff discuss two recent scientific papers on the potential metabolic connections to psychiatric disorders and mindfulness-based interventions.The first paper is a systematic review on the efficacy of low-carb and ketogenic diets for treating mood and anxiety disorders. They discuss the importance in defining what constitutes a low-carb or ketogenic diet in research studies. Our hosts also discuss the limited data available, with only 12 studies meeting the criteria for inclusion. However, the review indicates some positive preliminary findings for the use of these diets for conditions like bipolar disorder, depression and schizophrenia.The second paper is a meta-analysis examining mindfulness-based interventions for psychiatric disorders. It found mindfulness approaches were superior to non-evidence based treatments and comparable to standard therapies for conditions like anxiety and depression. Our hosts discuss the need for more research, but note the promising potential for simple lifestyle approaches like mindfulness, breathwork and nutrition to positively impact mental health.Overall, the episode highlights emerging science linking metabolic function to brain health and psychiatric wellbeing. Our hosts emphasize the need to continue conducting rigorous clinical trials in this nascent field of metabolic psychiatry and share their perspectives on implementing lifestyle interventions for optimal mental health.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this episode, our co-hosts Victoria Field, Dominic D'Agostino, PhD, and Angela Poff, PhD, discuss two recent scientific studies that focus on the potential metabolic connections to neurodegenerative diseases.Study 1: Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's diseaseThe study delves into the molecular changes causing a neuron's transition from healthy to degenerative, as seen in sporadic Alzheimer's, which is the most prevalent form of Alzheimer's disease and isn't directly inherited but arises from a mix of genetic and environmental factors. It proposes that metabolic changes in neurons due to altered gene expression might play a role in the disease's onset. Today's discussion touches upon the similarities between the findings in this study and the well-established Warburg Effect seen in cancer. This study may provide a clue to the molecular mechanisms behind Alzheimer's disease and open the door for exploration of potential treatments.Study 2: Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability, and potential clinical benefitsThis study measured the impact of a dietitian-guided ketogenic diet on MS patients on several markers including body composition, mood, mental health, and physical stamina. Our co-hosts discuss these findings as well as the secondary benefits of ketogenic therapies due to reduced MS symptoms, and the unique challenges of dietary vs pharmaceutical trials, such as ensuring accuracy, participant compliance and how to measure the intervention's effectiveness.If you'd like to read the papers referenced above, please find them here: Study 1 & Study 2In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field review recent research uncovering the potential impact of high blood glucose on stroke outcomes and the positive influence of exercise on Alzheimer's disease.An ischemic stroke happens when a blood vessel in the brain is occluded. This prevents oxygen and nutrients from reaching a region of the brain, ultimately causing some of that tissue to die. A hemorrhagic stroke occurs when a blood vessel bursts and causes bleeding into the brain, and is a less common but often more dangerous type of stroke. Hyperglycemia following an acute ischemic stroke is known as a predictor of poor clinical outcomes. In the first research paper discussed, researchers set out to explore whether this also holds true for intracerebral hemorrhage.The group also dives into a fascinating paper investigating the potential functional benefits of aerobic exercise in early Alzheimer's disease. Researchers investigated memory performance, executive function, and functional ability in association with exercise-related gains in cardiorespiratory fitness.Please find all research references below:Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trialHigher fasting blood glucose was associated with worse in-hospital clinical outcomes in patients with primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registryIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
Dr Sanjeev Goel interviews Dr Angela Poff, an research scientist on the science of ketones and ketosis and its health benefits.
You won't be surprised to hear that a night of poor sleep can affect how good you feel the next day. But did you know that disruptions in sleep quality, especially when they occur chronically, can have a major negative impact on your cognitive function, mood, and overall metabolic health?On this week's Journal Club episode of The Metabolic Link, co-hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field dive into two research publications exploring how meal timing in shift workers affects mood vulnerability and how light exposure during sleep impairs cardiometabolic function.The first study sought to determine if night-time eating contributed to the increased risk of depression and anxiety observed in shift workers. Amazingly, daytime-only eating during a simulated night work environment was not associated with the same negative health outcomes that appeared in those who ate during the night-time hours, suggesting a potential intervention to combat some of the health risks of shift work. The second study revealed how exposure to light during sleep can negatively affect glucose homeostasis, insulin sensitivity, sleep quality, heart rate, and heart rate variability, even after only a single night. Join the Metabolic Link co-hosts as they dive into the fascinating details of these studies!Publications discussed in this episode:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944904/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499546/In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
On this week's Journal Club episode of The Metabolic Link, co-hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field discuss two seemingly conflicting research studies exploring the effects of ketosis on muscle health in models of atrophy.Atrophy refers to the wasting of a body tissue or organ that occurs due to the degeneration of cells. Atrophy of vital tissues such as the skeletal muscle occurs in numerous pathological catabolic conditions, such as in cancer cachexia, motor neuron diseases, and following ischemic events, and it contributes greatly to morbidity and mortality in these patients. But skeletal muscle atrophy also occurs during aging. This is referred to as sarcopenia and is defined as an age-related, involuntary loss of skeletal muscle mass and strength. Its prevalence and impact in the elderly should make the prevention of sarcopenia a goal for all.Unsurprisingly, researchers are interested in designing methods to combat atrophy and sarcopenia. Due to the reported anti-catabolic metabolic and signaling properties of ketone bodies, researchers are studying how ketosis – either through the ketogenic diet or exogenous ketones – may play a therapeutic role in this condition. In their chat, the Metabolic Link co-hosts take a deep dive into two research papers that seem to produce conflicting results on the topic. But as always, the devil's in the details, and the team discusses some illuminating points that highlight just how complex interpreting scientific research can be.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!Publications discussed:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422126https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432582/In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field review recent research exploring the use of ketogenic metabolic therapy in Parkinson's Disease and Mental Illness.The first study discussed investigates the effects of a ketogenic diet applied prior to versus after the onset of Parkinson's disease in an animal model. Parkinson's disease is a highly prevalent disease, with over 6 million people worldwide who suffer from it. We understand the fundamental feature of Parkinson's disease is characterized by the loss of dopaminergic neurons, but researchers can't yet fully explain why this loss occurs. It's thought that neuro-inflammation might be a potential culprit and this study explores tackling such inflammation head-on with ketosis.The groups also dives into the exciting and rapidly developing field of metabolic psychiatry, including the potential use of ketogenic therapy in treating mental illness. They discuss a review article that highlights the emerging evidence supporting the use of ketogenic therapy in serious mental illness which covers several case studies in even the most challenging of mental illnesses, including psychosis. The mechanisms behind why this therapy might improve mental health are also discussed.Please find all research references below. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!Research papers discussed in episode:The Anti-Inflammatory Effect of Preventive Intervention with Ketogenic Diet Mediated by the Histone Acetylation of mGluR5 Promotor Region in Rat Parkinson's Disease Model: A Dual-Tracer PET Study: https://pubmed.ncbi.nlm.nih.gov/36105302/Ketogenic Therapy in Serious Mental Illness: Emerging Evidence: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387764/Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-6-10Ketogenic diet in the treatment of schizoaffective disorder: Two case studies: In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
In this week's Journal Club episode of The Metabolic Link, hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field explore metabolic therapy for cancer and why some researchers believe that the altered metabolism that drives tumor progression might be successfully targeted with novel metabolic focused approaches such as the ketogenic diet. They specifically review and evaluate a 2022 case study detailing the use of a calorie restricted ketogenic diet complementary to standard of care therapies in a patient with lung cancer that had metastasized to the brain. This emerging field of research is promising, but still in its infancy with many nuances to consider. Tune in for a thought-provoking discussion on this fascinating topic!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
Welcome to The Metabolic Link! A podcast that explores the common thread of metabolism in health and disease. In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field dive into the central link of metabolism that exists between most chronic illnesses, and how research in this growing field is unveiling new, promising strategies to optimize health and delay, prevent, or treat the development of disease.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
HVMN Podcast Podcast Notes Key Takeaways Explosion of ketones as a field of study: (1) ketones are a potent but accessible intervention (legal, accessed through diet or exogenous; (2) scientists are living the lifestyle of what they're studying which helps credibility, influence, experience“Ketones can rapidly change brain energy metabolism and the neuropharmacology of your brain in a way that's neuroprotective and anti-seizure.” – Dr. Dom D' AgostinoThere should be a duty to disseminate translatable, clear research to the public if funded through government meansKetones improve brain energy signaling metabolism, resilience, and enhance ability to maintain cognitive and physical performance in extreme environments – both environmental and physiologicEven within the ketogenic diet, there are many routes to go and options for exogenous ketones as supplement – like any diet, it needs to be personalized to your needs (a continuous glucose monitor can help)Starting in early middle age, natural uptake of glucose declines but ketone uptake is retained in the aging brain – ketones can circumvent glucose transporter and provide the energy for proper functionThe greatest effect of ketogenic diet on athletic performance will likely be over time where you'll see improvements in recovery, epigenetic effects, anti-inflammatory effectsTip: consuming carbohydrates with exogenous ketones (such as a ketone salt, MCT) will minimize glycemic variability “Completely excluding carbohydrates, fruit, and vegetables to the extent we do that with a clinical ketogenic diet is not optimal [for everyday]. A more diverse diet with plants, vegetables, different protein sources, with exogenous ketones would be more optimal.” – Dr. Dom D'AgostinoInstead, try a Mediterranean diet with exogenous ketones for supplementation with about 50-100g carbohydratesRead the full notes @ podcastnotes.orgDr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative. Dr. Latt Mansor and Geoff Woo met Dr. D'Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022. Key point topics and studies mentioned: Role of ketones and the future direction of ketone research in: Athletic performance/ extreme environment Mitochondrial protection in astronauts in space Cancers Metabolic psychiatry Alzheimer's and dementia Optimal blood ketone levels for health benefits Keto vs. carnivore vs. plant-based diets H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans, and we want to give you a special reward. Use HVMNPOD10 to get 10% off your next H.V.M.N. order. _______________________________________________________________ Learn More About H.V.M.N. here: https://hvmn.com/pod Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions!
HVMN Podcast Podcast Notes Key Takeaways Explosion of ketones as a field of study: (1) ketones are a potent but accessible intervention (legal, accessed through diet or exogenous; (2) scientists are living the lifestyle of what they're studying which helps credibility, influence, experience“Ketones can rapidly change brain energy metabolism and the neuropharmacology of your brain in a way that's neuroprotective and anti-seizure.” – Dr. Dom D' AgostinoThere should be a duty to disseminate translatable, clear research to the public if funded through government meansKetones improve brain energy signaling metabolism, resilience, and enhance ability to maintain cognitive and physical performance in extreme environments – both environmental and physiologicEven within the ketogenic diet, there are many routes to go and options for exogenous ketones as supplement – like any diet, it needs to be personalized to your needs (a continuous glucose monitor can help)Starting in early middle age, natural uptake of glucose declines but ketone uptake is retained in the aging brain – ketones can circumvent glucose transporter and provide the energy for proper functionThe greatest effect of ketogenic diet on athletic performance will likely be over time where you'll see improvements in recovery, epigenetic effects, anti-inflammatory effectsTip: consuming carbohydrates with exogenous ketones (such as a ketone salt, MCT) will minimize glycemic variability “Completely excluding carbohydrates, fruit, and vegetables to the extent we do that with a clinical ketogenic diet is not optimal [for everyday]. A more diverse diet with plants, vegetables, different protein sources, with exogenous ketones would be more optimal.” – Dr. Dom D'AgostinoInstead, try a Mediterranean diet with exogenous ketones for supplementation with about 50-100g carbohydratesRead the full notes @ podcastnotes.orgDr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative. Dr. Latt Mansor and Geoff Woo met Dr. D'Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022. Key point topics and studies mentioned: Role of ketones and the future direction of ketone research in: Athletic performance/ extreme environment Mitochondrial protection in astronauts in space Cancers Metabolic psychiatry Alzheimer's and dementia Optimal blood ketone levels for health benefits Keto vs. carnivore vs. plant-based diets H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans, and we want to give you a special reward. Use HVMNPOD10 to get 10% off your next H.V.M.N. order. _______________________________________________________________ Learn More About H.V.M.N. here: https://hvmn.com/pod Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions!
HVMN Podcast: Evidence-based Nutrition, Fitness, & Biohacking
Dr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative. Dr. Latt Mansor and Geoff Woo met Dr. D'Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022. Key point topics and studies mentioned: Role of ketones and the future direction of ketone research in: Athletic performance/ extreme environment Mitochondrial protection in astronauts in space Cancers Metabolic psychiatry Alzheimer's and dementia Optimal blood ketone levels for health benefits Keto vs. carnivore vs. plant-based diets H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans, and we want to give you a special reward. Use HVMNPOD10 to get 10% off your next H.V.M.N. order. _______________________________________________________________ Learn More About H.V.M.N. here: https://hvmn.com/pod Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions!
EPISODE #9 - Justin and Audra are joined by the founders of the Metabolic Health Summit, Angela Poff, PhD and Victoria Field, to talk all about metabolic health and what it means for families. From the in-depth discussion on the connection between metabolism and overall health to some simple tips on how to start making healthier choices today, this episode is definitely serving up some food for thought.
Today we are chatting with Victoria Field and Dr. Angela Poff, co-founders of the Metabolic Health Summit (MHS). MHS was created to bring the two worlds of science and society together and is one of our absolute favorite conferences. If you have an interest in the clinical application of metabolic health improvement you will absolutely love the Metabolic Health Summit and all the resources made available by the Metabolic Health Initiative. During this episode, we talk a lot about the influence of low-carb and ketogenic diets on neurological health, metabolic health, and more. Victoria and Angela also hooked us up with an incredible FREE resource summarizing the research findings surrounding advancements in ketogenic and metabolic therapy for neurological health, cancer, metabolic dysfunction, human optimization, and aging. If you are a health coach helping clients overcome metabolic dysfunction or simply someone who enjoys getting lost in evidence-based research, this episode is for you! To learn how to become a health coach or to up-level your skills and credentials as a health coach, visit primalhealthcoach.com.
Look up "keto cookbooks" and you find a plethora of options: Quick and Easy Ketogenic Cooking, Southern Keto, Ketogenic Cleanse, Keto Comfort Foods… It's fair to say this is a diet craze. But does it really work? This week on Florida Matters we talk with nutrition experts about the keto diet and how it can affect your health, from weight loss to possibly treating cancer. Florida Matters host Robin Sussingham talks to guests Dom D'Agostino, widely-known keto expert and Associate Professor of Molecular Pharmacology and Physiology at the University of South Florida; Angela Poff, Research Associate with USF's Department of Molecular Pharmacology and Physiology; and Jenna Bell, Registered Dietitian, triathlete and Senior Vice President at Pollock Communications
Look up "keto cookbooks" and you find a plethora of options: Quick and Easy Ketogenic Cooking, Southern Keto, Ketogenic Cleanse, Keto Comfort Foods… It's fair to say this is a diet craze. But does it really work? This week on Florida Matters we talk with nutrition experts about the keto diet and how it can affect your health, from weight loss to possibly treating cancer. Florida Matters host Robin Sussingham talks to guests Dom D'Agostino, widely-known keto expert and Associate Professor of Molecular Pharmacology and Physiology at the University of South Florida; Angela Poff, Research Associate with USF's Department of Molecular Pharmacology and Physiology; and Jenna Bell, Registered Dietitian, triathlete and Senior Vice President at Pollock Communications
In Episode 133 of The Real Food Reel we are joined by Angela Poff, Research Associate from Dom D'Agostino's, Laboratory of Nutritional and Metabolic Medicine. Today we explore the latest research into cancer and the ketogenic diet. Show Notes Angela Poff PhD on Facebook KetoNutrition.org The post RFR 133: The latest research into cancer and the ketogenic diet appeared first on The Wellness Couch.