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5 episodes with Warburg effect
3 episodes with Warburg effect
2 episodes with Warburg effect
2 episodes with Warburg effect
2 episodes with Warburg effect
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
In this compelling episode, Dr. Vera Tarman interviews Dr. Thomas Seyfried, a pioneer in the field of cancer metabolism. Dr. Seyfried challenges the mainstream view of cancer as a genetic disease and presents strong evidence that cancer is fundamentally a mitochondrial metabolic disorder. Dr. Thomas N. Seyfried is a distinguished American biologist and professor at Boston College, renowned for his pioneering work in cancer metabolism. With a Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, and postdoctoral training in neurochemistry at Yale University School of Medicine, Dr. Seyfried has dedicated his career to exploring the metabolic underpinnings of cancer and other neurological diseases. Dr. Seyfried is best known for his groundbreaking book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (2012), where he presents compelling evidence that cancer is primarily a mitochondrial metabolic disorder rather than a genetic one. This perspective builds upon the early 20th-century findings of Otto Warburg, who observed that cancer cells rely heavily on fermentation for energy production, even in the presence of oxygen—a phenomenon known as the Warburg effect. Dr. Seyfried's research suggests that targeting cancer's metabolic dependencies, such as glucose and glutamine, through dietary interventions like the ketogenic diet, could offer non-toxic therapeutic strategies. We explore: How cancer cells fuel themselves differently from healthy cells The connection between sugar, ultra-processed foods (UPFs), and cancer growth The Warburg Effect and the roles of glucose and glutamine in tumor development Whether refined sugar is carcinogenic like tobacco Why Dr. Seyfried believes ketogenic diets and caloric restriction can be powerful cancer therapies How his views align with metabolic psychiatry (Dr. Chris Palmer's Brain Energy) The controversial yet promising approach of "press-pulse" therapy The potential for preventing cancer through dietary change Follow: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html https://tomseyfried.com The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.
What if everything we thought we knew about cancer was wrong? For decades, scientists have debated what really causes cancer. Is it genetic mutations, as the Somatic Mutation Theory suggests? Is it a metabolic dysfunction, as the Metabolic Theory argues? Or is there a deeper, overlooked truth—one that could redefine cancer treatment as we know it? In this episode, Dr. Ralph Moss and Ben Moss break down the battle between competing cancer theories, why conventional wisdom is being challenged, and what the latest research is uncovering about cancer stem cells, metabolism, and the Warburg Effect.
Welcome to Protecting Your Nest with Dr. Tony Hampton. Sam Apple is on the faculty of the MA in Science Writing and MA in Writing programs at Johns Hopkins. Prior to his arrival at Johns Hopkins, Apple taught creative writing and journalism at the University of Pennsylvania for ten years. He holds a BA in English and Creative Writing from the University of Michigan and an MFA in Creative Nonfiction from Columbia University. He is the author of Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection. In this discussion, Dr. Tony and Sam talk about: (00:00) Intro (02:32) Why Sam is a writer and why he decided to write non-fiction (04:23) How Sam and his sister, Jessica—the co-founder of The Metabolic Revolution—became interested in metabolic health (07:00) The book that Sam wrote with Jayson Tatum (09:31) What got Sam into basketball (12:55) Why Sam chose to research and write about the cancer-diet connection (14:34) The Warburg Effect (17:17) Awareness in culture about how cancer can be prevented with nutrition/diet (21:15) Why sugar consumption puts you at a higher risk for cancer and how we can use it without running serious health risks (24:51) Who Sam's book, Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection, is for (28:23) The writing process for articles versus books (30:35) The power of stories and how Sam's book advances awareness about metabolic health Thank you for listening to Protecting Your Nest. For additional resources and information, please see the links below. Links: Resources Mentioned in this Episode: The Metabolic Revolution: https://www.metabolicrevolution.org Petition to Ban Ultra-Processed Foods from School Meals: https://petition.qomon.org/healthy-futures-ban-ultra-processed-foods-from-school-lunches/ Gary Taubes (website): https://garytaubes.com/ Nina Teicholz (website): https://ninateicholz.com/ Sam Apple: Books: https://www.amazon.com/stores/author/B001HMPI0M/allbooks?ingress=0&visitId=9c72ad44-1a9a-41a3-921f-b3bee7d7ed18 Website: https://www.samapple.com Instagram: https://www.instagram.com/samapplebooks/?hl=en X: https://x.com/Sam_Apple1 Dr. Tony Hampton: Linktree: https://linktr.ee/drtonyhampton Instagram Account: https://www.instagram.com/drtonyhampton/ LinkedIn Account: https://www.linkedin.com/in/drtonyhampton/ Ritmos Negros Podcast: https://podcasts.apple.com/us/podcast/ritmos-negros/id1534043495 Q Med: https://qmedcme.com Symposium for Metabolic Health Lectures: https://www.lowcarbusa.org/smhp-symposiums/san-diego-2022/ How Waking Up Every Day at 4:30 Can Change Your Life: https://www.youtube.com/watch?v=qOEB1Fr0_MM • • Keto Mojo: https://keto-mojo.com/speakers/tony-hampton/
Alkaline water is EVERYWHERE! But is there really any benefits behind the booming business? In this episode we explore higher pH water and its supposed impact on hydration, acid reflux, bone health, and even cancer prevention. Through discussions on acidity, alkaline diets, and the Warburg effect, we aim to separate fact from marketing, highlighting that while alkaline water might have minor benefits for specific conditions like osteoporosis, it does not prevent cancer or necessarily provide superior hydration. Moreover, we emphasize safe use when experimenting with alkaline water at home. Have you been buying this water and wanted to know the dirty on the whether it actually helps? Check out this episode with Your Doctor Friends today! 00:00 Introduction: What's Your Preferred Form of Water? 00:25 The Alkaline Water Experience 04:45 Understanding pH and Alkalinity 08:10 The Warburg Effect and Alkaline Diet 13:39 Can You Change Your Body's pH? 17:16 Measurable Outcomes and the Warburg Effect 17:38 The Complexity of Human Biology vs. Lab Data 18:13 The Dangers of DIY Health Research 19:51 The Butterfly Effect and Alkaline Water Myths 20:12 Alkaline Water and Acid Reflux 25:46 Alkaline Water and Bone Health 28:20 Hydration and Alkaline Water 32:22 Final Thoughts on Alkaline Water 35:13 Podcast Disclaimer Thanks for tuning in, friends! Please sign up for our “PULSE CHECK” monthly newsletter! Signup is easy, right on our website, and we PROMISE not to spam you. We just want to send you monthly cool articles, videos, and thoughts :) For more episodes, limited edition merch, to send us direct messages, and more, follow this link! Connect with us: Website: https://yourdoctorfriendspodcast.com/ Email us at yourdoctorfriendspodcast@gmail.com @your_doctor_friends on Instagram - Send/DM us a voice memo or question and we might play it/answer it on the show or on socials! @yourdoctorfriendspodcast1013 on YouTube @JeremyAllandMD on Instagram, Facebook, and Twitter/X @JuliaBrueneMD on Instagram
Matters Microbial #57: Pitting Metabolic Inhibitors Against Viruses September 18, 2024 Today, Dr. Tracie Delgado of the Biology Department at Seattle Pacific University joins the #QualityQuorum to discuss her undergraduate research team's explorations of how some herpesviruses can cause cancer . . . and how to use the host cell's metabolism to fight those viruses! Host: Mark O. Martin Guest: Tracie Delgado Download MM#57 (39 MB mp3, 65 min) Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode An overview of the herpesviruses as a group. A description of gammaherpesvirus, the type of herpesvirus with which Dr. Delagado and colleagues work. The relationship between some herpesviruses and cancer. The mysterious Warburg Effect, discussed by Dr. Delgado today. A wonderful TED talk by Dr. Delgado. A talk Dr. Delgado gave at a 2017 March for Science Event, arguing for more and better representation in STEM. An article about Dr. Delgado's journey to science. Dr, Delgado's research team's website with links to research articles that were discussed. Dr. Delgado's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com
Is Sugar Feeding Your Cancer?Discover how a simple shift in your diet and metabolism could render cancer and chronic disease powerless. In this episode Dr. Katie Deming brings an intriguing conversation with Dr. Thomas Seyfried, a renowned biology professor at Boston College and author of "Cancer as a Metabolic Disease." Dr. Seyfried challenges the traditional view of cancer as a genetic disease. His insights into the Warburg Effect, the role of mitochondria in cancer cells, and the impact of diet are eye-opening.Discover how dietary interventions play a crucial role in metabolic therapy. Chapters:07:41 - Weight Loss Led To Tumor Reduction, Not Drug.15:40 - The Argument That Cancer Is A Metabolic, Not Genetic 21:04 - Incentives Against Systemic Change In Cancer Treatment22:18 - How To Maintain Healthy Mitochondria30:30 - Why Monitor Glucose Ketone Index In Cancer Patients46:49 - The Key To Aging And Death01:03:55 - ATP is Life's EnergyDr. Deming helps bridge the gap between conventional cancer treatments and metabolic therapy. You learn about the importance of personalized treatment plans based on individual metabolic profiles and the latest research in the field.Join this enlightening conversation that could change the way you think about cancer and chronic disease management.Listen, learn, and prepare to challenge your understanding of chronic illnesses and explore a transformative perspective on cancer treatment.This episode promises to provide insights into the future approach of cancer treatment and how it could revolutionize patient care.GLOSSARY:Mitochondria's primary function is to produce energy in the form of adenosine triphosphate (ATP).Metabolic Therapy for cancer treatment involves a combination of dietary changes, possibly supplements, and in some cases, specific medications. The Glucose Ketone Index (GKI) as a way to monitor how your body is fueling itself – whether it's mainly using sugars (glucose) or burning fats (ketones). Grab Your Spot for the Free Radiant Health Online Workshop on March 5th: Sign Me Up!MORE FROM KATIE DEMING M.D. Take a Deeper Dive into Your Healing JourneyFollow Dr. Katie Deming's Substack HereWork with Dr. Katie:www.katiedeming.comFollow Dr. Katie Deming on Instagram:The.Conscious.OncologistPlease Support the Show Share this episode with a friend or family member Give a Review on Spotify Give a Review on Apple Podcast DISCLAIMER:The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.
Early onset cancers are on the rise in young adults, yet experts claim they 'don't know what's driving the surge.' Research finds Millennials have more chronic health conditions compared to other generations, likely from early introduction of processed foods. Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: https://bit.ly/berberine-fasting-accelerator Use code podcast to save 12% Link to Studies: https://bit.ly/3sMkdAu Tripping Over the Truth Book: https://amzn.to/3ENhbiG ----------------------Show Notes-------------------------- 00:00 Intro 06:94: early onset cancers in young 30:00 Rise in Cancers 1:15 Global increase 2:23 Metabolic health and cancer 3:00 Berberine and food cravings 3:50 Cancer no longer a disease of the elderly 4:15 Warburg Effect 5:11 High glucose is linked with cancer 6:35 Mainstream medicine food suggestions 7:20 Poor metabolic health and cancer 8:11 Otto Warburg 9:47 High A1C and Cancer 10:39 Glucose intake and mortality 11:15 Carbohydrate intake and cancer 12:00 Conclusions
Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological. Join my upcoming FREE keto LIVE training here: http://www.ketosismasterclass.com Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals. Mr. Cash has an MS in physics from the University of Oklahoma. As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business, Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm. In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer.
In this episode, our co-hosts Victoria Field, Dominic D'Agostino, PhD, and Angela Poff, PhD, discuss two recent scientific studies that focus on the potential metabolic connections to neurodegenerative diseases.Study 1: Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's diseaseThe study delves into the molecular changes causing a neuron's transition from healthy to degenerative, as seen in sporadic Alzheimer's, which is the most prevalent form of Alzheimer's disease and isn't directly inherited but arises from a mix of genetic and environmental factors. It proposes that metabolic changes in neurons due to altered gene expression might play a role in the disease's onset. Today's discussion touches upon the similarities between the findings in this study and the well-established Warburg Effect seen in cancer. This study may provide a clue to the molecular mechanisms behind Alzheimer's disease and open the door for exploration of potential treatments.Study 2: Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability, and potential clinical benefitsThis study measured the impact of a dietitian-guided ketogenic diet on MS patients on several markers including body composition, mood, mental health, and physical stamina. Our co-hosts discuss these findings as well as the secondary benefits of ketogenic therapies due to reduced MS symptoms, and the unique challenges of dietary vs pharmaceutical trials, such as ensuring accuracy, participant compliance and how to measure the intervention's effectiveness.If you'd like to read the papers referenced above, please find them here: Study 1 & Study 2In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
An Israeli study is saying that exercise, the real vitamin E, can reduce your risk of cancer by 72%. The study looked specifically at muscle building exercises. You may not know who Otto Warburg was, but he had a theory that cancer cells are different from normal cells. Normal cells thrive on protein and fat, whereas cancer cells feed on sugar. The premise of the Warburg Effect is that the more muscle you have, the more bins you have for storing glucose. Dr. Martin has often talked about having larger storage bins for glucose and that's why muscle building exercises are the most important exercises you can do, especially when it comes to preventing cancer.
The Cancer Pod: A Resource for Cancer Patients, Survivors, Caregivers & Everyone In Between.
High blood sugar (glucose) isn't desirable for a host of reasons, but is "feeding cancer" one of them? The truth is bittersweet and takes a little more clarification than a simple "yes" or "no." Tina & Leah discuss the origin-story of "sugar feeds cancer," tell you whether it's valid or not and give you some tips & tricks on how to have your cake and eat it too! High blood sugar and cancer progression, a reviewThe original Warburg Effect paper (1927)The “Reverse Warburg” effectThe Academy of Nutrition & Dietetics Summary on Sugar & CancerCarbons as the source of cancer cell metabolismMetabolic flexibility in cancer cells How exercise is anti-cancer and helps with glucose controlTypes of cancers associated with metabolic syndromeSupport the showSupport the podcast here! Or, go to Buymeacoffee. Either way, we'll give you a shout-out! Find our podcast useful? We hope so! Please review & rate us! (every bit helps!)Share this podcast with someone you love! Here's a link: https://podfollow.com/the-cancer-pod Email us: thecancerpod@gmail.comWe are @TheCancerPod Instagram Twitter Facebook THANK YOU!
Today, I am blessed to have here with me Sam Apple. He is on the faculty of the MA in Science Writing and MA in Writing programs at Johns Hopkins. Register your FREE spot for the next 7 day keto kickstart challenge with Dr Jason Fung, Dr Ken Berry, Dr Annette Boz and many others: http://www.ketokampchallenge.com This episode originally aired in December 2021 Prior to his arrival at Johns Hopkins, Apple taught creative writing and journalism at the University of Pennsylvania for ten years. He holds a BA in English and Creative Writing from the University of Michigan and an MFA in Creative Nonfiction from Columbia University. Apple is the author of Ravenous American Parent, and Schlepping Through the Alps. He has published short stories, personal essays, satires, and journalistic features on a wide range of topics. In recent years, he has primarily written about science and health. His work has appeared in The New York Times Magazine, The New Yorker, The Atlantic, Wired, The Los Angeles Times, The Financial Times Magazine, ESPN The Magazine, The MIT Technology Review, and McSweeney's, among many other publications. Schlepping Through the Alps was a finalist for the PEN America Award for a first work of nonfiction. In this episode, Sam talks about the inspiration behind his book Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet. We dive into Otto Warburg's work and how the Nazis protected him for his cancer science. Sam explains how sugar can promote cancer growth and what steps you can take to lower your insulin levels. Tune in as we chat about fasting, therapies for cancer, and the importance of exercise. Get Sam's book here: https://www.amazon.com/Ravenous-Warburg-Search-Cancer-Diet-Connection/dp/1631493159/benazadi-20 Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S EveryDay Dose Everything you love about coffee, none of what you don't — say goodbye to jitters, anxiety, crash, and digestive issues. https://everydaydose.superfiliate.com/KETOKAMP (5 FREE Travel Packs + Free Frother applied) PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:30] The Inspiration Behind Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Read Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection: https://www.amazon.com/Ravenous-Warburg-Search-Cancer-Diet-Connection/dp/1631493159/benazadi-20 Sam was interested in researching metabolic disease and metabolic health. Plus, Gary Taubes inspired him. Sam was really surprised to learn that that cancer was associated with diabetes, insulin resistance, obesity, and cardiovascular disease. He wanted to dig further on the connection between cancer and metabolic disease. [02:10] The Nazis Protected Warburg For His Cancer Research In 1923, Warburg makes this famous discovery called the Warburg Effect. Cancer cells take up a lot more glucose than other cells and burn it without oxygen; they ferment it, just like microorganisms do. Warburg also has made other discoveries about how cells breathe and use oxygen. He wins the Nobel Prize in 1931. In 1933, the Nazis come along. Despite having a Jewish father and being openly gay, the Nazis protected Warburg because they were interested in his cancer research. [06:50] Warburg's Studies Started To Disappear After The War After the war, Warburg's cancer research really starts to disappear. Australia in the 1950s famously discovered the structure of DNA. Eventually, we had a new sort of genetic understanding of cancer where we can now identify specific mutations. So, how cells take up glucose and shift their metabolism was considered irrelevant because of the study of genetics. Warburg's studies take peoeple back to diet, and there's a huge bias against taking diet seriously. [12:20] What Sugar Does To Promote Cancer Growth If cancer is about these metabolic shifts inside of a cell, what is it about the way we eat that affects the way a cell eats? In America, one out of three women are diagnosed with cancer within their lifetime. For men, it's about one in two. Cancer is closely linked to obesity. 13 of the deadliest cancers have been solidly linked to obesity. Sam wanted to know if obesity was causing cancer or if something was driving both. Elevated levels of the hormone insulin are responsible for obesity and give microscopic cancers a chance to grow and thrive. What is it about our diet that causes insulin to rise? Sugar! The increase in sugar consumption maps pretty closely to the rise of diabetes, heart disease, and cancer. [19:30] How A Keto Diet That Will Help You Prevent Cancer Sam is a huge believer that keto is a logical way to prevent cancer. The single most important thing you can do to improve your odds for cancer prevention is to keep your insulin levels low. Hyperinsulinemia promotes the growth of cancer. So, it's important to follow a diet that keeps your insulin levels down. [22:20] Intermittent Fasting Is Another Great Way To Lower Insulin Intermittent fasting is one very successful strategy for keeping insulin down. If you can fast consistently, it seems to work quite effectively on lowering insulin. Fasting can lead to weight loss because it lowers insulin levels in the body. Sam wants to point out that thin people can still have insulin resistance. In some ways, being naturally thin can actually be a disadvantage because you can't store subcutaneous fat. [26:30] How To Optimize Insulin and Glucose Levels To Be Proactive Instead of Reactive You can't outrun a bad diet. However, exercise can help you feel better and make you more inspired to follow a low-carb diet. After workouts, you can be inspired to eat healthily and continue to feel good. Once you understand that sugar is linked to cancer, it should help you ditch it during mealtime. [38:30] Finding Therapies To Target Specific Cancer Mutations When cancer can eat lots of glucose, it's no longer thinking about dying; it's thinking about doing a lot more things. Based on which particular mutation you have, the oncologist will devise a treatment. Unfortunately, targeted therapies to specific mutations haven't been as successful as we would have liked. However, there are some cases where therapies will successfully target mutations. [42:25] The Best Preventative Measures To Preventing Cancer In The Future Eliminate sugar from your diet. Definitely eliminate liquid sugar from your diet. If you are insulin resistant, you need to reduce those insulin levels. Stop smoking. Cut out refined carbohydrates. AND MUCH MORE! Resources from this episode: Check out Sam's Website: http://samapple.com/ Read Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection: https://www.amazon.com/Ravenous-Warburg-Search-Cancer-Diet-Connection/dp/1631493159/benazadi-20 Follow Sam Apple Twitter: https://twitter.com/sam_apple1 Instagram: https://www.instagram.com/samapplebooks/ Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a WatchKeto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Register your FREE spot for the next 7 day keto kickstart challenge with Dr Jason Fung, Dr Ken Berry, Dr Annette Boz and many others: http://www.ketokampchallenge.com Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S EveryDay Dose Everything you love about coffee, none of what you don't — say goodbye to jitters, anxiety, crash, and digestive issues. https://everydaydose.superfiliate.com/KETOKAMP (5 FREE Travel Packs + Free Frother applied) PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Let's discuss more about cancer, sugar and The Warburg effect. Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE : https://bit.ly/electrolyte-stix Use code podcast to save 12% Link to study & Images: https://youtu.be/I6_QmMuluiE Show Notes: 0:00 Intro 0:05 Breast, lung, colon, and brain cancer have been linked with deranged cellular metabolism. 0:27 Cancer is the second leading cause of mortality in the US. 1:00 Normal cells aerobically breakdown carbohydrates and fats to create ATP. 1:50 Cancer cells, in the presence of oxygen, ferment glucose to make pyruvate and lactate. 3:10 Mitochondria regulate preprogrammed cell death. 5:10 Dysregulated glucose metabolism fosters a tumor microenvironment that favors expansive growth. 5:35 PET scan is diagnostic imaging tool which uses a radioisotope glucose, fluorodeoxyglucose, that helps to diagnose cancer. 7:00 Metformin, which decreases glucose, is being used in cancer treatment and therapeutics. 9:10 Tumors require a chronic overexpression of lactate. Exercise is a transient acute increase in lactate. 10:04 Lactate can cause a cascade of events which helps the tumor grow more blood vessels. 11:25 By circumventing mitochondria for energy, it's ability to induce apoptosis is inhibited. 13:00 Your microenvironment can foster or inhibit the growth of a tumor. 14:45 Cold immersion is a mitochondrial therapy. 15:40 There is an association with a lower risk for breast cancer, total cancers and colorectal cancers for people who follow dietary prevention guidelines.
Sam Apple joins us to discuss his fascinating book 'Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection'. We discuss the connection between diet and cancer, and the Warburg Effect, which states that cancer cells thrive on dietary glucose, and why Sam thinks it's not entirely accurate because it ignores the role of insulin resistance. We also discuss Hitler's fascination with cancer research, which allowed Warburg to survive the Nazi era even though he was Jewish and gay, and Hitler's infamous addiction to sugar. We further discuss why this enormously important work has been ignored in modern science, why alternative genetic hypotheses are woefully inadequate, whether modern medicine can be reformed to focus on dietary causes of disease, and, of course, how bitcoin fixes this!References (All links are available on saifedean.com/podcast/150-the-cancer-diet-connection-with-sam-apple)Sam Apple's official website.Buy Sam's book on Amazon, The Book Shop and Norton.Chris PalmerEcontalk with Gary TaubesThe Nazi War on Cancer by Robert N. Proctor Lewis Cantley Harvard pageEnjoyed this episode? You can take part in podcast seminars, access Saifedean's courses – including his ongoing course ECO22: The Fiat Standard – and read chapters of his forthcoming book, Principles of Economics, by becoming a Saifedean.com member. Find out more here.
Have you ever considered that you could actually become cancer-proof? Thanks to my friend and Ancestral health expert Dr. Cate Shanahan, this rebroadcast episode will show you how you can actually make that happen. I even ask her what she would do if she received a cancer diagnosis tomorrow…and her answer may surprise you! Referencing the work of Dr. Thomas Seyfried, Dr. Cate explains that cancer is actually a metabolic disease, rather than a genetic disease. This implies that instead of aggressive chemo and radiation treatments designed to attack cancer at the genetic level, dietary modification could be the most effective strategy. This aligns with the Warburg Effect principle, which suggests cancer cells feed preferentially on glucose over regular cells. The idea is that starving cancer cells of glucose with fasting and ketogenic eating patterns makes it possible to shrink tumors and heal. To put it simply, metabolic diseases are most effectively treated through metabolic treatments. Enjoy this hard-hitting show! TIMESTAMPS: There is another avenue to explore when you get a cancer diagnosis. [01:46] Cancer is a metabolic disease rather than a genetic disease. [03:46] The Warburg Effect observes that cancer cells feed preferentially on glucose. [08:46] What is Dr. Cate's new job that brought her to Florida? She left the hospital job because her main interest is keeping people healthy. [10:47] The current system is not keeping people healthy. It boils down to the primary care doctor. [18:32] There is a new method of primary care which can be a more personal relationship with the patient and save money. [23:33] False positives can be deadly. There are many different ways to look at what cancer is. [24:45] There was much good research in the 1930's and 1940's learning about cancer and much of that has been forgotten. [32:46] If Brad got a cancer diagnosis today, the first thing she would suggest he do, would be Go over the diet to see if he were doing something wrong and watch a video by Dr. Seyfried. [36:32] Are all cancers the same? They are all downstream from metabolism. [43:12] Doctors who are studying cancers have varied opinions on the frequency of testing. [48:39] People are so confused. Who do you listen to? [50:09] The four pillars of human nutrition are fresh foods, fermented foods, meat on the bone, and organ meats. [52:05] Other than diet, we still must look at daily movement and good sleep habits. The vegetable oils promote cancer. [56:47] Canola oil is molecularly unstable and when you have too much of it in your diet, it destabilizes the DNA in your body. [01:00:02] Would it be undisputed that a dietary modification leading to increased HDL and reduced triglycerides is a positive? What do we learn from our blood chemistry? [01:09:00] LINKS: Brad Kearns.com Brad's Shopping page Paleo Clinic in Hungary Warburg Effect Deep Nutrition Dr. Cate Shanahan ABC Fine Wines and Spirits Primal Prescription Cancer is a Metabolic Disease The Fatburn Fix Biology of Belief Ageless Body, Timeless Mind Ancestral Supplements QUOTES: "You could have a hard drive that has a glitch, but if you have a really good operating system, you'd never know it." "If you assume cancer is a death sentence, you will over diagnose and over treat it." "30 to 40% of the average person's daily calories come from what I have to call “non-food” sources of carbs and fat, and those things promote cancer." Join Brad for more fun on: Instagram: @bradkearns1 Facebook: @bradkearnsjumphigh Twitter: @bradleykearns YouTube: @BradKearns TikTok: @bradkearns We appreciate all feedback, and questions for Q&A shows, emailed to podcast@bradventures.com. If you have a moment, please share an episode you like with a quick text message, or leave a review on your podcast app. Thank you! Check out each of these companies because they are absolutely awesome or they wouldn't occupy this revered space. Seriously, Brad won't promote anything he doesn't absolutely love and use in daily life. Brad's Macadamia Masterpiece: Mind-blowing, life-changing nut butter blend Male Optimization Formula with Organs (MOFO): Optimize testosterone naturally with 100% grassfed animal organ supplement BeautyCounter: Complete line of cosmetics tested to be free of typical toxins and endocrine disruptors. Try Brad's favorite vitamin-C skin serum and make the switch away from toxic mainstream skin-care products! Butcher Box: Convenient, affordable home delivery - free shipping! - of the highest quality meat, poultry, and seafood with customizable box design. Click here for special promotion. Bala Enzyme: Electrolyte and triple enzyme recovery drink mix. BRAD30 for 30% off BiOptimizers: Top quality performance supplements like magnesium, probiotics, and digestive enzymes. BRAD10 for 10% off Paleo Valley: Nutrient-rich, ancestral inspired health products. BRAD15 for 15% off BradNutrition.com: Coming soon - the ultimate whey protein superfuel formula for peak performance and longevity Ultimate Morning Routine Online Course: Learn how to custom-design an energizing, focusing morning exercise routine. Enroll now for earlybird discount Check out Brad Kearns Favorites Pagefor great products and discounts See omnystudio.com/listener for privacy information. See omnystudio.com/listener for privacy information.
Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological. Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals. Mr. Cash has an MS in physics from the University of Oklahoma. As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business, Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm. In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer.
In today's episode, we tackle one of the most controversial questions in the world of cancer nutrition. The question is, "Does sugar feed cancer?" I address:The metabolic theory of cancer (where the idea comes from), why it is controversial, an additional fuel source for cancer cells that doesn't always get discussed, my opinion on the matter as a nutrition professional, Ketogenic diets (benefits and drawbacks) the role that sugar plays in inflammation, how to keep blood sugar levels stable and build a healthy meal. References: The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies byby Dr. Nasha Winters ND FABNO LAc DiplOM, Jess Higgins Kelley MNT, et al. New Clarity on the Warburg Effect published by the National Cancer Insitute, 2021,Alba Luengo PhD, Zhaoqi Li PhD, and Matt Vander Heiden PhD. Beyond Sugar: What Cancer Cells Need to Grow By Matthew Tontonoz of the Memorial Sloan Kettering Cancer Center, 2019 No Sugar, No Cancer? A Look at the Evidence By Matthew Tontonoz of the Memorial Sloan Kettering Cancer Center, 2016Breast Cancer Grounding Kit Freebie (contains a recipe, meditation and journal prompts to get you through the stress and anxiety that come with a breast cancer diagnosis) Facts/Feelings Workbook: Tamoxifen Are you feeling really overwhelmed and scared about the recommendation that your oncologist has made regarding taking Tamoxifen? This workbook allows you to put the facts alongside your personal feeling on the issue so you can find peace with your decision to take or not take this controversial hormonal therapy. Free Guided Meditations on Insight Timer Email me via juni@junibwell.com or through my website www.junibwell.comor find me on social media:Instagram and Tik Tok: @junibwellFacebook: Juni Bucher, NTP LinkedIn: Juni Bucher, NTP May I ask a small favor? Please review the podcast, if you are enjoying it ,so that others can find this information. It helps those in need and I would be so grateful! Thank you so much. Wishing you well, Juni
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi's and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him. It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/livelongerworld SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld SAM APPLE LINKS: Ravenous book: https://amzn.to/3yT9qpd Website: http://www.samapple.com/ Twitter: https://twitter.com/Sam_Apple1 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS: 0:00 Cancer as a disease of modern societies 1:27 Otto Warburg & the Cancer-Metabolic Connection 2:27 Warburg's research on respiration 4:02 Why was cancer skyrocketing in Western societies? 9:17 Warburg Effect: Warburg's research on cancer cells 15:00 Why do cancer cells take up so much glucose? 17:44 Cancer-Diet Connection 21:44 Cancer, Ketogenic diets & Fasting 23:43 Hibernation of the metabolic story of cancer 27:20 Hitler's connection with cancer 30:07 Warburg's arrogance 31:51 Why does cancer need glucose? 38:46 Warburg's stigma: connecting with Nazi's 40:51 Is insulin responsible for cancer? 48:00 Science is not immune from politics 50:24 Prostate cancer & obesity 52:13 Pendulum swing in cancer research 54:40 Mitochondria & Cancer Connection 57:07 Nazi's fixation on cancer Episode Show Notes: https://livelongerworld.substack.com/p/sapple Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
0:00 Introduction13:05 Who is Sam Apple?15:00 Why did it take 5 years to write the book?16:15 Germany and Science: Warburg's childhood experience19:37 Did Einstein save Warburg's life?24:10 Nazi ideology: can Germany beat Cancer?28:50 Warburg's gay life in Nazi Germany33:36 The Warburg Effect (what causes cancer)38:00 Jews and German science40:04 The Nazi's, cancer and the "Jewish Problem"43:26 Did Hitler save Warburg from the gas chambers?48:38 The end of WW11. Warburg survives...53:33 Was Warburg right about cancer?53:42 The end of Warburg
metabolism and aerobic systemtest at muscle level with a Moxy sensoraerobic use is a dial, not an on/off switchtesting VO2maxCooper Run or 2K on Rowercompare to the populationTemplate MWF = lifting: Cardio T, Th, maybe SatModality, start with a bike if you have the option, less depletion of O2 overallIn the Phys Flex Course, I go over pH and O2 / CO2 mechanics and how to program for itThis podcast is brought to you by the Physiologic Flexibility Certification course. In the course, I talk about the body's homeostatic regulators and how you can train them. The benefit is enhanced recovery and greater robustness. We cover breathing techniques, CWI, sauna, HIIT, diet, and more. Sign up for the waitlist, and you'll be notified as soon as the course opens.Articles:3 Metabolic Tests by Dr Mike T Nelsonhttps://miketnelson.com/3-metabolic-tests-from-rmr-to-vo2-max/How To Test Your VO2 Max with the Concept 2 Rowerhttps://miketnelson.com/forgotten-factor-in-training/Podcastshttps://flex-diet-podcast.simplecast.com/episodes/s2-ep-23-cranial-face-structures-nasal-breathing-orthodontics-tongue-position-and-more-unlikely-performance-limiters-interview-with-zac-cupples-nUobdSwo/transcripthttps://miketnelson.com/interview-with-james-nestor-author-of-breath-the-new-science-of-a-lost-art-2/ReferencesBrooks GA. The Science and Translation of Lactate Shuttle Theory. Cell Metab. 2018 Apr 3;27(4):757-785. doi: 10.1016/j.cmet.2018.03.008. PMID: 29617642. https://pubmed.ncbi.nlm.nih.gov/29617642/Brooks GA. Lactate as a fulcrum of metabolism. Redox Biol. 2020 Aug;35:101454. doi: 10.1016/j.redox.2020.101454. Epub 2020 Feb 9. PMID: 32113910; PMCID: PMC7284908. https://pubmed.ncbi.nlm.nih.gov/32113910/Lacour JR. Activité musculaire et dépense d'énergie [Muscle activity and energy expenditure]. Rev Mal Respir. 2011 Dec;28(10):1278-92. French. doi: 10.1016/j.rmr.2011.06.014. Epub 2011 Nov 6. PMID: 22152936. https://pubmed.ncbi.nlm.nih.gov/22152936/Ortenblad N, Macdonald WA, Sahlin K. Glycolysis in contracting rat skeletal muscle is controlled by factors related to energy state. Biochem J. 2009 May 13;420(2):161-8. doi: 10.1042/BJ20082135. PMID: 19250062. https://pubmed.ncbi.nlm.nih.gov/19250062/Rothman DL, Shulman RG. Two transition states of the glycogen shunt and two steady states of gene expression support metabolic flexibility and the Warburg effect in cancer. Neoplasia. 2021 Sep;23(9):879-886. doi: 10.1016/j.neo.2021.06.004. Epub 2021 Jul 21. PMID: 34303218; PMCID: PMC8322124. https://pubmed.ncbi.nlm.nih.gov/34303218/Shulman RG, Rothman DL. The "glycogen shunt" in exercising muscle: A role for glycogen in muscle energetics and fatigue. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):457-61. doi: 10.1073/pnas.98.2.457. PMID: 11209049; PMCID: PMC14608. https://pubmed.ncbi.nlm.nih.gov/11209049/Shulman RG, Hyder F, Rothman DL. Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6417-22. doi: 10.1073/pnas.101129298. Epub 2001 May 8. PMID: 11344262; PMCID: PMC33483. https://pubmed.ncbi.nlm.nih.gov/11344262/Shulman, Robert & Rothman, Douglas. (2015). Homeostasis and the glycogen shunt explains aerobic ethanol production in yeast. Proceedings of the National Academy of Sciences of the United States of America. 112. 10.1073/pnas.1510730112. https://www.pnas.org/content/112/35/10902.figures-onlyShulman RG. Glycogen turnover forms lactate during exercise. Exerc Sport Sci Rev. 2005 Oct;33(4):157-62. doi: 10.1097/00003677-200510000-00002. PMID: 16239831. https://pubmed.ncbi.nlm.nih.gov/16239831/Shulman RG, Rothman DL. The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer. Trends Cancer. 2017 Nov;3(11):761-767. doi: 10.1016/j.trecan.2017.09.007. Epub 2017 Nov 6. PMID: 29120752. https://pubmed.ncbi.nlm.nih.gov/29120752/
Cancer is one of the most terrifying things to happen to anyone. Not only that, cancer treatments are always in a rush to remove tumours, making you think that this is the only way. Clinical practice is years behind clinical research, and there are now additional and alternative ways to boost your health and treat cancer. The research can be difficult to understand and read through, especially when you're in the thick of cancer. Our guests today share their newest project — a documentary all about the metabolic approach to cancer with researchers and cancer thrivers all in one place! In this episode, Maggie Jones shares how her experience with cancer became the inspiration for CanceRevolution. She credits both traditional therapy and metabolic therapy as the key to treating her condition and prolonging her life. Brad and Maggie hope that their documentary can reach people and spread the word about the metabolic approach. Don't just blindly follow doctors who won't have the time to do research for you. Instead, start taking ownership of your health! If you want to learn more about fighting cancer through the metabolic approach and the CanceRevolution documentary, then this episode is for you! Here are three reasons why you should listen to the full episode: Discover how Maggie's journey with cancer led her and her husband to work on the upcoming documentary, CanceRevolution. Learn about traditional radiation therapy and how incorporating the metabolic approach to cancer can help you! Find out how to take ownership of your health and stay disciplined even after beating cancer. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle? Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. 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Episode Highlights [04:00] Maggie's Journey with Cancer In 2018, Maggie was diagnosed with lung cancer and was told that she had less than a year to live. At first, Maggie accepted her fate, but she started to learn more about how she can help her body heal. She took up fasting, a ketogenic diet, organic foods, and metabolic treatments. A year after her diagnosis, she was cancer-free. While Maggie is not dealing with cancer anymore, she has been dealing with the effects of cancer medicine that was used on her. Cancer treatment often feels too rushed. It would be better to spread out treatments and lower their dosage. [08:27] How Maggie's Cancer Affected Brad Brad tried to hide how much Maggie's cancer impacted him emotionally. At the same time, he felt that Maggie was strong enough to face and survive cancer. He learned all about metabolic treatments through Maggie and served as her reminder. Brad even started eating Maggie's diet and fasted with her. [12:13] How Fasting Can Help Before Treatments Maggie used to think eating healthy was good. After a tumour surgery, she was vomiting and sweating. However, she tried fasting before the surgery and found that she felt great after the procedure. Fasting is known to be able to “close” normal cells while the cancer cells are still active and looking for energy. When exposed to radiation, the cancer cells get more affected. Clinical research takes around 17 years before becoming part of clinical practice. [15:39] Genetics and Epigenetics Combining hyperbaric therapy, a strict diet, and exogenous ketones can make a big difference. Yet, this practice is not common in cancer treatment. The industry focuses more on DNA, even though there have been more discoveries about biochemistry since then. Genetics and epigenetics are different. The former is about the genes themselves, while the latter looks at what turns the genes on and off. Our environment and behaviour affect the way our genes work. Differentiation of cells is the true cause of aging. [18:49] The Warburg Effect Cancers can and will change their way of using energy. Even when oxygen is available, cancer cells use fermentation, which is not as efficient. The Warburg effect is already a fact. What's not being studied is why this is happening. There is the genetic theory where genes mutate and cause cell changes, while the other theory is the other way around. Cutting off the cancer cells' food source is the start. This includes glucose, glutamine, and so much more. You can block cancer cell growth with diet, off label drugs, and specific protocols for specific cancers. Learn more about these in the full episode! [24:48] Why Starving Cancer Can Help The biggest criticism of starving cancer is that cancer cells can adapt to different metabolic pathways. While starving cancer may not lead to curing it, it can help you buy time. The drug protocols have lower side effects than traditional therapy and radiation surgery. [25:48] How to Use Press Pulse Due to cancer's adaptability, you can expect to change protocols every so often. Maggie shares that press pulse can be helpful. This is using a certain protocol first, then switching to something else once cancer adapts and eventually reintroducing the first protocol. [27:57] Always Be Vigilant Brad cautions people not to think they're cured of cancer and go back to unhealthy foods and habits. We all have some cancer cells. Your immune system needs to be strong enough to fight against it. Even if your cancer markers are gone, retaining a ketogenic diet can still be helpful. Exogenous ketones are not fermentable as a food source for cancer. [33:05] Maggie and Brad's Documentary, CanceRevolution Maggie and Brad's documentary about cancer includes guests who are at the forefront of cancer research and people who have experienced cancer. The documentary is still a work in progress. Donations are highly appreciated. This is all about sharing the metabolic approach to cancer and understanding how cancer works. In the medical profession, doctors can lose their license if they go all-in on the metabolic approach, even if it has been proven effective. The profession has shown that money drives what is promoted or not. Thus, we need to be proactive and take ownership of our health. [42:36] Take Ownership of Your Health While somatic mutation, genetic theory, and metabolic theory are not yet proven, technologies can be built around it to prove it. For example, the PET scan is a cancer diagnostics tool based on the Warburg Effect. As a patient, you have to be your own advocate and not just blindly listen to doctors. Read books and clinical research. Remember that you're in control of your body. 7 Powerful Quotes [9:18] “When, we were together, I just always had this feeling that she was going to make it through. I don't know why, but I was just like — I knew my wife. I knew how strong she was. And if anyone is going to fight this disease, it's her.” — Bradley [25:05] “I was given the six to eight months to live. My starving cancer bought me another three years of life. This is time to address the next pathway when it comes up and to wait for the next conventional therapy that might help me and all the new research that's coming out. Though it's not going to cure your cancer, it's going to buy you time and buy you incredible quality of life.” — Maggie [28:30] “It's really hard to be completely cured. Your cancer is always somewhere. We all have some. My immune system is holding its own, whilst Maggie's wasn't. That's basically what happened is her immune system couldn't fight it off anymore.” — Bradley [32:21] “So having these exogenous ketones can really help just for athletes, as well as cancer patients, but it's really — it's teaching your body to be metabolically flexible.” — Lisa [34:12] “...she's [Dr Nasha Winters] lived such a powerful life helping others. She was diagnosed too late in her progression to ever receive chemotherapy. And I think that's really what we can all strive for is even if scans aren't perfect, you can still live such a long, full life and don't give up hope.” — Maggie [49:32] “One of the things that Maggie and I tell try and tell everyone is you have to be — as a patient, you have to be your own advocate. Do not just listen to what your doctor is saying — your oncologist or any doctor. They only meet with you for a half hour, right? Like Maggie sees her oncologist for like about a half hour once every three months.” — Bradley [55:11] “I'm not unlucky. There are very clear therapeutic things that I can do, that I did to get cancer, that I can do to get out of it. And we need to promote this message of you're in control of your medical destiny. Don't just listen to somebody else who tells you it's a lost cause.” — Maggie Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! How to Starve Cancer by Jane McLelland Lifespan by David Sinclair with Matthew D LaPlante Lifespan Podcast with Dr David Sinclair Want to learn more about how to manage and treat cancer? Check out our previous episodes: Episode 231: The Immune System and How It Fights Cancer Cells and Viruses with Dr Elizabeth Yurth Episode 229: Cancer Treatments: Starve Cancer, Be Free From It with Jane McLelland Episode 227: Fighting Cancer and Other Diseases Using the Ketogenic Diet with Dr Dominic D'Agostino Learn more about the use of Vitamin C from our past episodes: Episode 171: Vitamin C for the Critically Ill with Dr Anita Carr Episode 169: Vitamin C in Sepsis and ARDS Treatment with Dr Alpha “Berry” Fowler Episode 168: Vitamin C for Cancer Treatment with Professor Margaret Vissers Episode 167: Curing the Uncurable with Vitamin C with Dr Thomas Levy MD, JD Episode 164: The Power of Intravenous Vitamin C with Dr Ron Hunninghake Press-pulse: a novel therapeutic strategy for the metabolic management of cancer Support CanceRevolution and learn more about the documentary! Stay updated with CanceRevolution: Twitter | Facebook | Instagram | Youtube Connect with Brad Jones: LinkedIn | Website | Twitter | Instagram Connect with Maggie Jones: LinkedIn About Maggie and Brad Jones Maggie Jones has over 20 years of media experience and is currently the Vice President of Newsrooms Systems for South China Morning Post and Vice President of Product for Tribune Publishing and the Los Angeles Times. She is also the founder of Jones Wellness, LLC, a content creation, marketing, and consulting firm in the wellness and nutrition space. In addition, she is a stage 4 cancer thriver who credits metabolic therapy and conventional targeted therapy in prolonging her life. Brad Jones has over 20 years of filmmaking experience and is the Executive Producer of Jones Wellness, LLC. He has edited films, from a Peabody Award-winning documentary to the highest-rated shows on MTV and CMT and has spent over a decade working at the Sundance Film Lab and Festival. Know more and support their upcoming documentary, CanceRevolution! You can also connect with Brad on his website, LinkedIn, Twitter, and Instagram. Connect with Maggie on LinkedIn. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn more about the metabolic approach to cancer. Have any questions about the different approaches to cancer? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa
Sam Apple is the author of the book Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection, published in May 2021. In this episode, Sam describes the fascinating life story of Otto Warburg, a Nobel Prize-winning scientist who, despite being both Jewish and gay, survived Nazi Germany because of his valuable research on cellular metabolism and cancer. Sam describes Warburg's observation that cancer cells consume large amounts of glucose anaerobically – a phenomenon subsequently known as the “Warburg Effect” – and relates how Warburg's seminal work on this topic was largely forgotten after the discovery of oncogenes, only to regain relevance decades later within the field of cancer biology. Sam sheds light on the current debate around Warburg's interpretation of the causes of cancer, and Peter gives his personal take on the matter. Finally, Peter and Sam tie it all together with a discussion about cancer prevention, the role of hyperinsulinemia, and the link between dietary sugar and cancer. We discuss: Sam's interest in Otto Warburg and work as a writer [2:30]; Otto Warburg's dedication to science and his complicated life in Germany [14:00]; Warburg's interest in cancer and early discoveries about cellular consumption of oxygen [23:00]; The role models who fueled Warburg's desire to make a great discovery [34:15]; How Warburg described the primary and secondary causes of cancer [42:15]; Warburg's Nobel Prize in 1931 [45:45]; Warburg's life and work during WWII in Nazi Germany [46:30]; Warburg's research in hydrogen transfers and coenzymes—his best science? [59:45]; Warburg's decision to stay in Germany after WWII [1:03:30]; Discovery of oncogenes in the 1970s and the decline in interest in Warburg's ideas [1:07:30]; The renaissance of Warburg's ideas on cancer metabolism and a new explanation for the Warburg Effect [1:13:45]; The argument against the Warburg Effect as a primary cause of cancer and the potential role hyperinsulinemia [1:21:15]; Identifying primary and secondary causes of cancer for the purpose of prevention [1:27:00]; The link between sugar, fructose, and cancer [1:35:30]; Sam's reflections on the work that went into Ravenous [1:39:45]; More View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Learn More About Peter Attia Sign Up to Receive Peter's Weekly Newsletter Connect With Peter on Twitter, Instagram, Facebook & YouTube
Today, I am blessed to have here with me Sam Apple. He is on the faculty of the MA in Science Writing and MA in Writing programs at Johns Hopkins. Prior to his arrival at Johns Hopkins, Apple taught creative writing and journalism at the University of Pennsylvania for ten years. He holds a BA in English and Creative Writing from the University of Michigan and an MFA in Creative Nonfiction from Columbia University. Apple is the author of Ravenous American Parent, and Schlepping Through the Alps. He has published short stories, personal essays, satires, and journalistic features on a wide range of topics. In recent years, he has primarily written about science and health. His work has appeared in The New York Times Magazine, The New Yorker, The Atlantic, Wired, The Los Angeles Times, The Financial Times Magazine, ESPN The Magazine, The MIT Technology Review, and McSweeney's, among many other publications. Schlepping Through the Alps was a finalist for the PEN America Award for a first work of nonfiction. In this episode, Sam talks about the inspiration behind his book Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet. We dive into Otto Warburg's work and how the Nazis protected him for his cancer science. Sam explains how sugar can promote cancer growth and what steps you can take to lower your insulin levels. Tune in as we chat about fasting, therapies for cancer, and the importance of exercise. Get Sam's book here: https://www.amazon.com/Ravenous-Warburg-Search-Cancer-Diet-Connection/dp/1631493159/benazadi-20 Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use BEN10 at checkout for 10% off your order. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:30] The Inspiration Behind Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Read Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection: https://www.amazon.com/Ravenous-Warburg-Search-Cancer-Diet-Connection/dp/1631493159/benazadi-20 Sam was interested in researching metabolic disease and metabolic health. Plus, Gary Taubes inspired him. Sam was really surprised to learn that that cancer was associated with diabetes, insulin resistance, obesity, and cardiovascular disease. He wanted to dig further on the connection between cancer and metabolic disease. [02:10] The Nazis Protected Warburg For His Cancer Research In 1923, Warburg makes this famous discovery called the Warburg Effect. Cancer cells take up a lot more glucose than other cells and burn it without oxygen; they ferment it, just like microorganisms do. Warburg also has made other discoveries about how cells breathe and use oxygen. He wins the Nobel Prize in 1931. In 1933, the Nazis come along. Despite having a Jewish father and being openly gay, the Nazis protected Warburg because they were interested in his cancer research. [06:50] Warburg's Studies Started To Disappear After The War After the war, Warburg's cancer research really starts to disappear. Australia in the 1950s famously discovered the structure of DNA. Eventually, we had a new sort of genetic understanding of cancer where we can now identify specific mutations. So, how cells take up glucose and shift their metabolism was considered irrelevant because of the study of genetics. Warburg's studies take peoeple back to diet, and there's a huge bias against taking diet seriously. [12:20] What Sugar Does To Promote Cancer Growth If cancer is about these metabolic shifts inside of a cell, what is it about the way we eat that affects the way a cell eats? In America, one out of three women are diagnosed with cancer within their lifetime. For men, it's about one in two. Cancer is closely linked to obesity. 13 of the deadliest cancers have been solidly linked to obesity. Sam wanted to know if obesity was causing cancer or if something was driving both. Elevated levels of the hormone insulin are responsible for obesity and give microscopic cancers a chance to grow and thrive. What is it about our diet that causes insulin to rise? Sugar! The increase in sugar consumption maps pretty closely to the rise of diabetes, heart disease, and cancer. [19:30] How A Keto Diet That Will Help You Prevent Cancer Sam is a huge believer that keto is a logical way to prevent cancer. The single most important thing you can do to improve your odds for cancer prevention is to keep your insulin levels low. Hyperinsulinemia promotes the growth of cancer. So, it's important to follow a diet that keeps your insulin levels down. [22:20] Intermittent Fasting Is Another Great Way To Lower Insulin Intermittent fasting is one very successful strategy for keeping insulin down. If you can fast consistently, it seems to work quite effectively on lowering insulin. Fasting can lead to weight loss because it lowers insulin levels in the body. Sam wants to point out that thin people can still have insulin resistance. In some ways, being naturally thin can actually be a disadvantage because you can't store subcutaneous fat. [26:30] How To Optimize Insulin and Glucose Levels To Be Proactive Instead of Reactive You can't outrun a bad diet. However, exercise can help you feel better and make you more inspired to follow a low-carb diet. After workouts, you can be inspired to eat healthily and continue to feel good. Once you understand that sugar is linked to cancer, it should help you ditch it during mealtime. [38:30] Finding Therapies To Target Specific Cancer Mutations When cancer can eat lots of glucose, it's no longer thinking about dying; it's thinking about doing a lot more things. Based on which particular mutation you have, the oncologist will devise a treatment. Unfortunately, targeted therapies to specific mutations haven't been as successful as we would have liked. However, there are some cases where therapies will successfully target mutations. [42:25] The Best Preventative Measures To Preventing Cancer In The Future Eliminate sugar from your diet. Definitely eliminate liquid sugar from your diet. If you are insulin resistant, you need to reduce those insulin levels. Stop smoking. Cut out refined carbohydrates. AND MUCH MORE! Resources from this episode: Check out Sam's Website: http://samapple.com/ Read Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection: https://www.amazon.com/Ravenous-Warburg-Search-Cancer-Diet-Connection/dp/1631493159/benazadi-20 Follow Sam Apple Twitter: https://twitter.com/sam_apple1 Instagram: https://www.instagram.com/samapplebooks/ Join theKeto Kamp Academy: https://ketokampacademy.com/7-day-trial-a WatchKeto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E S P ON S O R S PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use BEN10 at checkout for 10% off your order. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. 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On Episode 4 of the Conscious Breathing Podcast with Steve Scott, Dr. Daniel Thomas shows us the next-generation strategies he is successfully using with his cancer patients who come from all over the world to get treatment from him at his medical clinic in the Orlando Florida area. Dr. Thomas is a highly educated, experienced, and forward-thinking physician. For over 30 years, he has helped people all over the world by providing innovative solutions to reverse disease, improve mental and physical vigor, and increase lifespan. His expertise is in the practical application of cutting-edge biomedical research. Dr. Thomas spends 20-30 hours a week poring over the latest scientific literature in search of promising therapeutic strategies. In this show, he goes over his 8 step treatment protocol. You'll learn why the most aggressive tumors are hypoxic and how carbon dioxide treatments may be an effective tool in the battle against cancer. If you or a loved one has cancer, make sure to listen to the entire show and learn some strategies you may have never heard of before. 00:00:00 Introduction 00:01:19 Breathing with the Relaxator 00:01.51 Introducing Dr. Daniel Thomas 00:02:53 Dr. Daniels Tomas' background & how he got interested in cancer 00:04:39 The reason for reading science journals instead of medical journals 00:05:48 The Gerson Institute nutritional therapy 00:06:39 The history of the Gerson Therapy 00:09:37 What is the cause of cancer? Genomic vs metabolic 00:11:31 Recent discovery - cancer's love affair of iron 00:12:33 Cancer & iron levels, absorption & excretion 00:13:56 Could high iron levels be a potential sign of cancer? 00:15:12 Optimal ferritin levels 00:15:46 The benefit of blood donation in reducing iron levels & the advantage of female menstruation, especially for protecting the heart 00:16:40 Pulling down iron levels with natural supplementation & commercial drugs 00:18:03 Excess iron & genetic mutations. Iron's role in assisting or magnifying cancer's ability to get the energy it needs, especially from glucose 00:19:15 Cancer's need for glucose & how cancer gets its energy. Glutamine, fatty acids & autophagy. 00:21:09 Glycolysis vs aerobic use of sugar & The “Warburg Effect” 00:22:36 The use of carbon dioxide in cancer treatment – BodyStream & Carbohaler. Hypoxia & Normaxia. Tumor & tissue oxygenation. Bohr Effect. 00:25:08 Preferences for how to use carbon dioxide for different types of cancer, topically (BodyStream) vs inhalation (Carbohaler) 00:27:01 Breathing methods & the importance of oxygenating the cancer tumor to make it vulnerable. IV therapies. Ozonated salin. Increasing efficacy of chemotherapy & radiation. 00:29:04 Hyperthermia & heating tumor tissue for increased blood flow & delivery of chemo drugs or natural compounds. Cytotoxic effect. 00:30:57 How heat affects hemoglobin's affinity for oxygen. 00:31:59 Dr. Daniel's protocols for the cancer patients that seek him out & why patients usually get the best results when combining conventional & alternative medicine. Reducing risk of developing chemo resistance & radio resistance 00:35:02 Next generation medicine, going beyond alternative medicine & blending the best of both worlds. Functional medicine. Integrative medicine. 00:37:04 Diet & cancer. The use of repurposed medicine, Ivermectin. A twofold approach. 00:39:23 Hyperthermia. The procedure of heating up the cancer tumor 00:41:02 Benefits of regular sauna & infrared sauna in comparison to medical hyperthermia machines? 00:42:07 What is more important - treating the whole person (environment of tumor), vs the tumor itself? Dr. Daniel's eightfold approach to cancer treatment 00:43:54 The role of the essential amino acid methionine & why Dr. Daniel advocates for a plant based diet for most cancer patients 00:46:19 Dr. Daniel's walks us through his eightfold approach to treating cancer First approach – to target cancer's addiction to methionine & iron & its resistance to ferroptosis (iron mediated cell death) 00:47:50 Second approach –to inhibit cancer's ability to metabolize glucose or glutamine for energy. Metformin. Sodium selenite. 00:49:03 Recent data on shutting down fat metabolism by cancer 00:50:25 Third approach – Increasing tumor blood flow & reducing tumor hypoxia 00:51:08 Fourth approach – Lowering inflammatory markers 00:51:39 Fifth approach – Immunotherapy. Stimulating the immune system & removing the barriers that can inhibit a strong immune system from working 00:52:14 Sixth approach – Suppressing the metastatic potential of cancer. Help preventing the lymphatic system from spreading the cancer. The reason people die from cancer & the use of lithium. 00:53:29 Seventh approach – The importance of not only targeting cancer cells, but also cancer stem cells. 00:53:43 Eight approach – Promoting efficient removal of tumor debris & and how your body removes the tumor debris 00:54:56 The different stages of cancer. The possibility of integrating conventional therapies with alternative therapies & the reason for Dr. Daniel's high success rate 00:58:02 The importance of hope in people's success rate 01:00:21 Having a student's perspective & being open minded 01:01:34 Solasonin & solamargin, natural compounds found in eggplant that potentially can work as strong as chemo & might give lasting immunity to cancer 01:04:07 Plant compounds may hold the key to all ills of mankind 01:04:57 Different approaches for different types of cancer 01:07:43 The different treatment options offered at Dr. Daniel Thomas' clinic & how to get in touch.
The Oncology Journal Club - Delivering Oncology News DifferentlyThe Oncology Podcast, brought to you by Oncology News Australia, is proud to present Episode 54 in our series The Oncology Journal Club.Welcome to this week's episode of The OJC. Join Eva Segelov, Craig Underhill and Hans Prenen as they chat through the latest papers.Eva talks us through tumour burden and efficacy of immune-checkpoint inhibitor. Hans gets stuck into aligning tumour mutational burden quantification across diagnostic platforms and Craig details the CheckMate 142 Study.You'll also find out how to deliver Cancer Care in the Wake of a Cyber Attack and phew, Hans can relax – Eva tells us that coffee is still good for us!We've also the first guest in our new ‘The Paper That Changed My practice' segment – thanks Merve aka our favourite kiwi, yes it's Chris Jackson!. Full bios and the list of all papers discussed are available on our website.For the latest oncology news visit www.oncologynews.com.au and for regular oncology updates for healthcare professionals, subscribe for free to get the weekly The Oncology Newsletter.The Oncology Podcast - An Australian Oncology Perspective
Thank you for joining us for another episode of the Low Carb MD Podcast. Sam Apple is a health care and medical writer. He did his undergrad at University of Michigan, his masters at Columbia. He has worked for University of Pennsylvania, is currently on the faculty of the MA in Science Writing and MA in Writing programs at Johns Hopkins, and has written extensively on metformin and metabolic health. Soon, he will be releasing his brand new book, Ravenous, which tackles, among others, the subjects of the Warburg Effect and metabolic health's relationship to cancer. In this discussion, Tro, Brian, and Sam talk about the role of metabolic health in preventing cancer, the effect that hyperinsulinemia has an cancer growth, the Warburg Effect and the work of Otto Warburg as it pertains to cancer cell research, how sugar, stress, and poor sleep habits raise insulin, the unfortunate lack of emphasis on preventative treatments for cancer in research, how the rise in cancer diagnoses follows the same curve as the rise of the western diet, and whether there is a diet out there that treats cancer. For more information, please see the links below. Thank you for listening! Links: Sam Apple: Website Twitter Dr. Brian Lenzkes: Website Dr. Tro Kalayjian: Website
Qi Chen revealed the mechanisms of action for IVC. The ascorbate-generated peroxide is essential in exerting anti-tumor effects. IVC is multiple-targeting and causes genotoxic and metabolic stress that make cancer cells more susceptible than normal cells. The differentiated sensitivity has a root in the Warburg Effect.Qi's research on IVC and cancer treatment has been widely recognized by the academic and scientific society. The work has been featured in prestigious journals, and reported by national and international health media.Qi Chen's lab documented that the combination of IVC with chemotherapies had synergistic effects in tumor inhibition. With collaboration with clinicians, Qi translated the positive animal studies into clinical trials. A Phase I/II study in stage III and IV ovarian cancer patients showed that adding IVC to standard platinum/taxane chemotherapy was safe and well-tolerated. In addition, it reduced toxic side effects associated with chemotherapy. Time to disease relapse/progress trended towards prolongation. We also conducted a Phase I/II study in locally advanced and metastatic pancreatic cancer. IVC did not interfere with pharmacokinetics of chemotherapeutic drugs, and potentially improved progress free survival.
The true nature of a scientist is to approach situations with curiosity and explore all possibilities and that is exactly why I like chatting with people that challenge the mainstream narrative about a particular disease or illness, particular a disease that is ruthlessly defended by the industry that profits from its existence. This episode presents some new ideas and perspectives around cancer and if you’re on a journey and collecting information, this episode will be a useful pitstop along the way.In This Episode We Cover:The Cancer BusinessCancer metabolism and the Warburg EffectWhy the Genetic/DNA Theory of Cancer is Incorrect***Join the Facebook Group Here - Answer the group Entry questions to Apply for the Program to Lose Weight and Be your Healthiest Self: https://www.facebook.com/groups/IntermittentFastingForHealth/***--SOCIAL MEDIA--MARK SLOANWebsite: https://endalldisease.com/YouTube: https://www.youtube.com/channel/UCM1gCPhk_keYePdDZQjeTDw--MATTY LANSDOWNInstagram: https://www.instagram.com/mattylansdown/Linkedin: https://www.linkedin.com/in/matty-lansdown/Join the Facebook Group Here(formerly Health Hacks For Humans):https://bit.ly/IntermittentFastingForHealthWebsite: https://mattylansdown.com/--Thanks for checking out the show. If you enjoyed this episode and want to hear more then please consider subscribing. If you really loved this episode and want to just tell the world about it then please take a screenshot and share it on your Instagram story and be sure to tag me so I know you're tuning in. 5-star ratings and positive reviews really help the podcast too so thank you in advance!......Music credits:Intro/Outro track Tropic Love by "Diviners feat. Contacreast" www.youtube.com/watch?v=DoJfqJsGk8s
Low carb vs keto, easy weight loss, ketones vs blood sugar, the FreeStyle Libre, Continuous Glucose Monitoring (CGM), the GKI ( Glucose Ketone Index), the DrBoz ratio, Dr. Bosworth & keto, the Warburg effect, CIMTs ( Carotid Intima-Media Thickness ) test & others. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: ·PrevMed's website·PrevMed's YouTube channel·PrevMed's Facebook page
In this episode of The Moss Report Podcast, Mary Hardy, MD, and David Wales, talk with our host, Ralph W. Moss, Ph.D. about recent research on an unusual treatment: fermented wheat germ extract (FWGE). Recent research has shown FWGE can reduce the abnormal metabolism of cancer cells. This raises the prospect that FWGE might heal cancer cells by reversing the “Warburg Effect,” thus converting a glucose-fermenting cell back into a normal cell. The research into wheat germ has a long history and a promising future, as scientific papers show verifiable results and FWGE becomes more widely available. Mary Hardy, MD, is board-certified in internal medicine and a specialist in botanical and integrative medicine. She has been combining complementary and alternative therapies with Western medicine for over thirty years in both her clinical practice and research projects. She also has a long-standing interest in patients who have shown exceptional responses during cancer care.
Nutrient or toxin… which one do you choose? Seems simply right? When you’re a cancer patient in the mainstream system you don’t geta choice, you’re very quickly knees deep in toxic therapy, and hey, sometimes toxic lives require toxic treatment, but often, increased toxic load doesn’t produce highly favourable outcomes. Not to mention that types of foods that we put into our body and not in fact really nutrition and thus they add to the toxic load… what a rabbit hole right? Well you are in the right place as Dr Nasha Winters and I unpack a few of the approaches cancer therapy which do not add toxic burden to the body and can be used, even alongside conventional therapy to enhance its effects at a lesser dose - amazing right!In This Episode We Cover:The Warburg Effect and why conventional therapy doesn’t really engage this hallmark of cancerHow your metabolism works and how to develop metabolic flexibilityWhy low carb, keto and intermittent fasting are powerful therapeutic agentsJoin the Facebook Group Here(formerly Health Hacks For Humans):https://www.facebook.com/groups/IntermittentFastingForHealth/***--SOCIAL MEDIA--DR NASHA WINTERSWebsite: https://www.drnasha.com/Instagram: https://www.instagram.com/drnashawinters/Facebook: https://www.facebook.com/drnashainc/Mistletoe Therapy for Cancer: https://believebig.org/--MATTY LANSDOWNInstagram: https://www.instagram.com/mattylansdown/Website: https://mattylansdown.com/--Got a question? Or maybe even a guest suggestion? Email through - podcast@mattylansdown.com--Thanks for checking out the show. If you enjoyed this episode and want to hear more then please consider subscribing. If you really loved this episode and want to just tell the world about it then please take a screenshot and share it on your Instagram story and be sure to tag me so I know you're tuning in. 5 star ratings and positive reviews really help the podcast too so thank you in advance!......Music credits:Intro/Outro track Tropic Love by "Diviners feat. Contacreast" www.youtube.com/watch?v=DoJfqJsGk8s
00:06:54 - Skip setup music 00:06:55 - Georgi and Danny catch-up, experiences with mask-wearing, misconceptions about mask-wearing (i.e., the idea behind the mask is wearing it forever) 00:13:00 - Some things Danny wanted to address about the Ray interviews ('Ray is being goaded into talking about conspiracy theories') 00:34:56 - Simple metabolic change sufficient to turn "normal" cells into "cancer" 00:43:56 - Cytokine storm in COVID-19 / sepsis due to "cancer metabolism" (Warburg Effect) 00:49:32 - The World Might Actually Run Out of People 01:03:28 - Dietary PUFA causes (reversible) male infertility and androgen deficiency 01:08:15 - www.raypeatwiki.com 01:10:25 - Male sexual function does NOT require estrogen 01:15:54 - Simply diluting "old blood" has the same anti-aging effects as parabiosis 01:20:58 - Estrogen and histamine, not HPV, drive cervical cancer 01:24:24 - Niacinamide (vitamin B3) may cure HIV (human study) 01:28:55 - Question: vitamins D and A in milk? 01:31:11 - Question: suggestions for varicocele 01:36:14 - Question: treating h. pylori 01:40:50 - Question: policosanol dosages 01:47:43 - Question: caffeine, DHT, progesterone 01:54:03 - Question: zinc, selenium, copper 01:58:57 - Question: progesterone and DHEA for muscular dystrophy 02:01:08 - Question: suggestions for breast cancer 02:05:04 - Question: does having a source of glycine make methionine restriction unnecessary? 02:06:30 - Question: ED, porn, dopamine, libido, "addiction" 02:09:31 - Question: suggestions for asthma 02:11:41 - Question: what is the status of Georgi's studies? 02:14:37 - Question: how much policosanol and octacosanol in TocoVit (Idealabs vitamin E) 02:16:10 - Question: tips for athletes, insomnia, limitation on sugar consumption 02:20:07 - Question: suggestions for psoriasis
In episode 279 of The Real Food Reel we are joined by Cliff Harvey to explore the publication, ‘Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition'. We discuss how caloric restriction differs from a ketogenic diet in regards to cancer treatment and how we must consider both the Warburg Effect and the reverse hypothesis, that while some cancer cells thrive on glucose, others thrive on ketone bodies. We then discuss glutamine and the relevance of protein intake versus the prevention of muscle wastage, the role of a holistic and individualised approach to cancer treatment, future directions including the press-pulse strategy and so much more. Cliff Harvey online: http://www.cliffharvey.com The Carbohydrate Appropriate Diet: http://www.cliffharvey.com/books.html Holistic Performance Academy: https://holisticperformance.ac.nz Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition: https://doi.org/10.1101/2020.03.09.984302 Click below to download transcript: The post RFR 279: The Latest in Keto Cancer Research with Cliff Harvey, PhD appeared first on The Wellness Couch.
In this episode, Lew Cantley, Professor of cancer biology and Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College in NYC, walks us through his amazing discovery of phosphoinositide 3-kinase (PI3K) and the implications for the care of patients with cancer. He explains various combinations of therapies being tested and used, including the possibility of pairing prescriptive nutritional therapies to increase the efficacy of drugs like PI3K inhibitors. Lew also explains the metabolic nature of cancer through the lens of his research into the connection between sugar consumption, insulin resistance, and tumor growth. Additionally, Lew provides some details about his exciting new clinical trial that is just now enrolling patients with stage 4 breast cancer and endometrial cancer. We discuss: Teaching science through the lens of discovery—A better approach to learning science [5:15]; The metabolic nature of cancer, mitochondria, and a more nuanced explanation of the Warburg Effect [8:30]; The observation that convinced Lew to stop eating sugar [20:15]; The connection between obesity, insulin resistance, and cancer [25:30]; Sugar consumption and tumor growth—What did Lew’s 2019 paper find? [32:00]; Natural sugar vs. HFCS, fruit vs. fruit juice, insulin response and cancer growth [43:00]; Increasing efficacy of PI3K inhibitors with ketogenic diets, SGLT2 inhibitors, and metformin [53:30]; Lew’s clinical trial enrolling stage 4 breast cancer and endometrial cancer patients [1:07:30]; Pairing diet with drug could be the future of cancer treatment [1:09:30]; PI3K inhibitors on the market, alpha vs. delta isoform, and the possibility of pairing them with a food prescription [1:16:15]; What questions will Lew be focused on in the next chapter of his career? [1:22:15]; Lew's early work that ultimately led to the discovery of PI3K [1:27:30]; Studying the mechanism by which mitochondria make ATP [1:30:45]; How understanding the mechanism by which insulin drove glucose uptake into a cell got Lew closer to finding PI3K [1:38:15]; How Lew knew PI3K was important in driving the growth of cancer cells [1:55:00]; Lew’s unlikely observation of phosphorylation at the 3' position of the inositol ring resulting in the formation of phosphatidylinositol-3-phosphate [1:59:00]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/lewcantley/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.23.049056v1?rss=1 Authors: DECK, M., Van Hameren, G., Campbell, G., Bernard-Marissal, N., Devaux, J., Berthelot, J., Lattard, A., Medard, J.-J., Gautier, B., Quintana, P., Chao De La Barca, J. M., Reynier, P., Lenaers, G., Chrast, R., Tricaud, N. Abstract: Whether glial cells use a particular metabolism to support axonal metabolism and function remains controversial. We show here that the deletion of PKM2, an enzyme essential for the Warburg effect, in mature myelinating Schwann cells (mSC) of mice leads to a deficit of lactate in these cells and in peripheral nerves, and to motor defects despite no alteration of the myelin sheath. When electrically stimulated, peripheral nerve axons of mutant mice failed to maintain lactate homeostasis, resulting in an impaired production of mitochondrial ATP. Action potential propagation was not changed but axonal mitochondria transport was altered, muscle axon terminals retracted and motor neurons showed cellular stress. Further reducing lactate availability through dichloroacetate treatment definitely aggravated axonal malfunction in mutant mice. Thus, cancer-like Warburg effect is essential in mSC for the long term maintenance of peripheral nerve axons physiology and function. Copy rights belong to original authors. Visit the link for more info
Jenna completed her BSc in Immunology at the University of Glasgow in 2002 followed by a PhD in the National Heart and Lung Institute at Imperial College London. She has held positions in infectious disease at The London School of Hygiene & Tropical Medicine as well as working in both Biotech specialising in clinical retraining of immunological tolerance using oral immunotherapy and in Pharma looking at management of inflammation using dietary fibre and metabolic endotoxemia. Jenna is currently a lecturer at the University of Sussex where she chairs the Board of Study for various degrees in the biomedical arena. Jenna's Instagram Jennas Website Jenna's Book "Immunity: The Science of Staying Well" Jenna's Twitter In this episode we cover: The coincidental timing of Jenna's book release with the current COVID-19 situation Jenna's extensive background in immunology What is the immune system, what different parts make it up and how does it work to protect us? What are some of the factors that make COVID-19 so effective at spreading? What are cytokines and how are they involved in the "cytokine storm", characteristic of serious cases of COVID-19? They way our own immune system can be responsible for some of damage caused during an infection Why do some people get more serious cases of COVID-19 than others? How can nutrition affect the way viruses behave in our bodies? The difference between taking supplements to fix a genuine deficiency and taking more than you need. More isn't always better. What's the role of oxidative stress in our immune response? Is "boosting" our immune system possible with diet/supplements or is it even something we would want to do? The massive amount of misinformation, circulating right now about nutrition and immunity and the role the media plays What role do macronutrients and energy metabolism play in the immune response? The importance of eating in energy balance. Metabolic reprogramming, the Warburg Effect and glucose use in immune cells. The research around and potential role of fasting and ketosis in immuno-modulation. How does exercise effect immunity. Can you do too much? The role of resistance exercise and muscle mass in maintaining our thymus gland and immune function Cumulative stress from multiple sources and how it can affect immunity How can the microbiome and gut-health play a part in our immune response Other lifestyle factors that we can manage to help with immunity
Today, I am grateful to have here with me, Dr. Jeff Matheson, co-founder of an all-natural migraine and headache centre, which promotes a non-narcotic approach to pain and headache management. Plus, Dr. Jeff Matheson is the co-founder and medical director of Pure Life Science. Dr. Jeff Matheson successfully practiced medicine in emergency departments across Canada and internationally, from Ontario, Newfoundland, and Abu Dhabi in the United Arab Emirates. He later was appointed Medical Director of Med-EmergInc in 1998, a company dedicated to staffing underserved hospitals in Canada. Dr. Matheson has traveled extensively throughout Europe, the Middle East, Africa, and South East Asia and well as Oceania. According to Dr. Matheson, “traveling is the best education!” Dr. Matheson is an enthusiastic believer, as well as being immersed in other cultures. Similarly, if one does not listen to patients, one won’t hear what is necessary to understand the patient’s problem, i.e., the patient’s “culture.” It is with this ability to listen and empathize with the patients that Dr. Matheson allows an accurate diagnosis and develop sustainable solutions, optimizing health, and patient outcomes. If a solution cannot be determined, resources will be dedicated, through the involvement of alternative care specialists, ascertaining the best possible treatment for the patient by trying to treat causes, not just manage symptoms. In this episode, Dr. Matheson opens up the show discussing his introduction to the ketogenic diet and how exactly quality fats will promote health. Dr. Matheson dives deep into the relationship between the cell membrane and our DNA. Plus, he speaks about the troubles of fish oil and why we should never take the supplement. Stay tuned to hear Dr. Matheson reveal other damaging fats for our bodies and all about his Pure Form Omegas. PureForm Plant Based Omegas: http://bit.ly/2OL0FWU . [05:45] About Dr. Matheson Matheson realized there was no standardization for pain management in Canada. He created a standardization; now, all pain clinics need to use his system. Matheson had all sorts of pain himself. After trying a specific diet, all of the pain melted away. Then, he started prescribing the diet to his patients, who had similar results. Now, Dr. Matheson wants to introduce people to the proper fats for our bodies. Bad fats can harm you just as much as carbohydrates can. [11:10] How Quality Fats Promote Health The structure of the cell is based on fat. The cell membrane is a fatty membrane. If you do not have a membrane, then you do not have a cell. If we are putting bad fats in our bodies, then we will have a weak cell membrane. How does the cell membrane interact with the rest of the cell? The mitochondria are also made up of fats – it is loaded with the membrane. Unhealthy cell membranes will result in lethargy. [13:40] Relationship Between the Cell Membrane and our DNA 25% - 33% of your cell membrane is made up of omega-6. 40% of your mitochondria membrane is made up of omega-6. 100% of your cardiolipin is made up of omega-6. When you keep DNA under repair, you need proper omega-6. Our brains take 20% of our metabolic energy. If our mitochondria have bad fats in them, it can’t produce the energy that the nucleus requires to stay healthy. We are being damaged by radiation, so it requires a lot of energy to keep it repaired. If we can’t keep it repaired, we will run into mutations and possibly cancers. [16:20] What’s the Issue with Fish Oil? Fish oil became popular when researchers found out Inuit people had low rates of heart disease. They assumed their pristine health was because of eating so much fish. However, the Inuit people didn’t eat that much fish. Their diets consisted mostly of seal, whale, and blubber. Most fish oil studies are not very well done scientifically. Fish oils are way too unstable for humans to be consuming. It is taxing our ability to keep the oil from oxidizing. A majority of the fish oil on the shelves are already oxidized – there is no way that can be healthy for you. It turns out that you only need 4.3 milligrams of DHA a day for a healthy brain. Matheson is amazed at how many punches the human body can take and still function. [22:10] How to Get DHA Without Fish Oil Most people get enough DHA. DHA can hang around the brain for about 18 months. There isn’t a significant turnover, and we do not need tons of it. You have to have the right fats to make DHA in the first place. [23:00] Where Does the Fish Oil End Up? The fish oil will get broken down. The body will recognize it as a toxin. Most of the fish oil is artificial, and the body cannot even recognize its chemical makeup. You can decrease the efficiency of mitochondria by introducing DHA. [28:30] The Most Pristine Fish Oil in the World Your body can get rid of the fish oil pretty fast. If you are on fish oil for a month, do you feel any better on it? If you feel good on the fish oil, then something positive is happening. Fish oil can have a cortisol effect at first. However, it is not a long-term or healthy effect. [36:40] Damaging Fats Plant oils that are processed and rancid olive oils. When you oxidize an oil, it starts to smell bad. So, the manufactures deodorize the oil. Now, the oil cannot take oxygen. Putting that oil in your cell membrane will result in the Warburg Effect. If you decrease the oxygen in your cells, then they will turn cancerous. 60% of us will get cancer in our lifetime. In the 1900s, it was 3%. [43:30] About Pure Form Omegas Pure Form is all organized and cold-pressed under a blanket of nitrogen. The oil has not touched oxygen, and every capsule has a bubble in it. We used to eat things straight from the ground. Now, we don’t have a choice anymore. People will feel the difference, and they will feel it quickly. AND MUCH MORE! Resources from this episode: Check out Pure Life Science Follow Pure Life Science Facebook Twitter Pinterest Instagram YouTube Email sales@pureformomega.com Call 905-812-8333 Visit the HMC Centre Website Follow Dr. Jeff Matheson LinkedIn Facebook Listen to The Keto Kamp Podcast with Brian Peskin Buy the Pure Form Omegas Learn about Low Carb USA Watch The Truth About Fish Oil & Three Reasons to Avoid It Join the Keto Kamp Academy WatchKeto Kamp on YouTube $39 Bottle of Olive Oil for $1.00 Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Dr. Wagner is a clinical nephrologist. He is the Director of the Kidney Institute of New Mexico as well as being the acting Associate Chief of Research and Renal Section Chief for the VA in Albuquerque. In this episode we discuss recent evidence urging caution over the use of gadolinium based contrast agents.To fund Dr. Wagner's work you can donate to the Kidney Institute of New Mexico athttps://www.unmfund.org/fund/unm-kidn...Links:Reveal Pharmaceuticals, Gadolinium-free MRI contrast agents products.http://www.revealpharma.comPeter Caravan PhD. Director, Institute for Innovation in Imaging Massachusetts and Associate Professor of Radiology at Harvard Medical School.Twitter- @PeterCaravanThe FDA adverse event reporting systemhttps://open.fda.gov/data/faers/Gadolinium-based contrast agents: why nephrologists need to be concernedhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416778/
Special offerIf you are a frequent listener to our podcast and have yet to read the magazine, we have put together a special offer for you.You can get hold of a recent issue of the magazine for free. Simply register your details here: https://news.wddty.com/landing/free-issue/ In the latest What Doctors Don’t Tell You (WDDTY) podcast, editors Lynne McTaggart and Bryan Hubbard review the routine procedure of steroid injections in arthritic joints. The shots are supposed to reduce pain and improve mobility, but new research suggests they also speed up bone deterioration. The Warburg effect was a discovery by biophysicist Otto Warburg that cancer cells act differently and consume sugar – instead of oxygen – to survive and develop. This astonishing should have transformed oncology, but didn’t, with sceptics claiming it was unproven. Now the final piece in the Warburg jigsaw has been discovered – and Bryan and Lynne discuss how this could transform the way we see and treat cancer. Nobody seems to know what depression really is – but it’s certainly not a serotonin chemical imbalance, even though the theory launched the SSRI antidepressant market. Instead, ‘talking cures’, such as CBT work just as well, as Bryan and Lynne uncover. To wrap up proceedings, they review a new opioid scandal looming, the dangerous side effect of the only prescription drug for cystitis, and how the avocado is as effective as a statin drug.
The Warburg effect -- why cancer cells prefer glycolysis; A synthetic version of a chemical from turmeric kills cancer cells; Nicotinimide supplement helps prevent skin cancer in high risk individuals; Review of the VITAL study that criticizes Vitamin D and Fish Oil usefulness; Is there a mold toxin problem with extracted citric acid? Turning chemicals from wood processing into valium and other useful chemicals! How the molecules in mucus are antimicrobial; Technological shorts that help you walk better seem very silly to Dr. Dawn!
Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer and metabolic wellness. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. Time stamps 5:56 Nasa Neemo 23 17:38 Organization/entrepreneurship/ and prioritization. 19:38 Human Metabolism and the ketogenic diet. 29:07 Glucose Metabolism 31:06 Do we need glucose to run our body? 32:43 What changes in our body when we don't consume carbohydrates. 39:50 Medium chain triglycerides. 42:45 How do we adapt to ketosis? 44:52 Calorie restriction benefits of the ketogenic diet. 48:53 Neuro protective effects of ketones. 49:58 Anti-inflammatory mechanisms of ketones. 53:45 Histone deacetylase 56:40 Epigenome. 58:00 Krebs Cycle. 59:51 Mitochondrial Function with Ketones/oxidative stress. 71:17 Carbohydrate based metabolism and oxidative stress.. 72:55 Mean amplitude glucose excursions. 76:10 Glucose, inflammation , oxidative stress and insulin resistance. 77:20 The Warburg Effect 89:35 Mitochondria Damage or nucleus damage in regards to cancer. 92:37 Ketogenic diet and Mitochondria protection. 94:20 The most radical thing Dom has done recently. 95:45 Where to find Dom online/upcoming projects. Dom’s info: Instagram: dominic.dagostino.kt Twitter: DominicDAgosti2 Web: ketonutrition.org Ancestral Supplements https://ancestralsupplements.com/ use the promo code “SaladinoMD” on the shopify site for 10% off. JOOVV: www.joovv.com/paul My contact information: PATREON: https://www.patreon.com/paulsaladinomd SOCIAL MEDIA Instagram: @paulsaladinomd Website: paulsaladinomd.com Twitter:@mdsaladino Facebook: Paul Saladino MD email: paulsaladinomd@gmail.com Be sure to subscribe for more medicine and lifestyle content. Stay radical!
Dr. Cate Shanahan, the author of Deep Nutrition and Food Rules, pulls no punches when discussing how our conventional view of screening and treating cancer could be ill-advised. Referencing the work of Dr. Thomas Seyfried, Cate explains that cancer is actually a metabolic disease, rather than a genetic disease. This implies that instead of aggressive chemo and radiation treatment to attack cancer at the genetic level, the dietary modification could be the most effective strategy. This aligns with Warburg Effect principle, which suggests cancer cells feed preferentially on glucose, at a rate greater than regular cells. The idea is that starving cancer cells of glucose with fasting and ketogenic eating patterns makes it possible to shrink tumors and heal. Cate tackles the big C question, our biggest fear: What would you do if you were diagnosed with cancer tomorrow? Cate says she would get to business with fasting and ketogenic eating, and head off to Turkey, yes Turkey!, to participate in cutting edge insulin therapy. While it might be unsettling to rethink the template strategy of cancer-fighting, Cate's commentary can help you reflect further about how your thoughts, beliefs, and food choices affect your overall health. Enjoy this discussion with one of the great leaders of the ancestral health movement, and be sure to read Deep Nutrition to learn the hows and whys about choosing the most nutritious foods that your genes expect for optimum health.
Paul Anderson, ND, shares insights from his 25-year career in treating complex diseases with natural remedies, with a focus on cancer. We discuss exciting new research about how natural therapies affect cancer development and progression and how the once chemo-and-radiation-centered field of oncology is embracing lower side effect therapies: keto, fasting and immune modulators. New Book: Outside the Box Cancer Therapies: https://amzn.to/2rC2PMe Connect with Dr. Paul: http://www.drabooks.com ----New Low-Carb eCourse------------ Raw Veggie Bread Creations: https://courses.highintensityhealth.com/p/raw-veggie-bread-creations-spring ----Key Timestamps------------ 03:24 Dr. Anderson’s travel health strategies. 05:03 Breast cancer recurrence dropped with fasting 05:21 The biochemistry changes after 3 to 4 months of intermittent fasting of 13 to 14 hours, even in non-cancer patients. 07:29 Intermittent fasting. 09:02 Hospitals are embracing intermittent fasting around chemo 11:15 People who respond best to natural treatment are those who tend to the basics and take care of their overall health. 13:42 Chemotherapy has evolved in the past 5 to 10 years to be more targeted. 15:08 Some targeted chemotherapies work well, others have deadly side effects or cancer coming back stronger. 16:10 The trophoblastic theory is the cancer stem cell theory. Once the main cancer tumor has been destroyed, the cancer stem cells step back and wait. 18:27 The more we quiet inflammation and regulate blood sugar, the less likely it is that cancer stem cells will activate. 19:19 Secondary prevention includes and goes beyond diet and lifestyle. Other issues must be addressed: immune issues, chronic infections in the lymphatic system, toxin burdens, and hormonal aberrations. 24:36 Aberrant thoughts affect the immune system. 28:03 Cancer stem cells stay with the blueprint and the rest are the soldier cancer cells that we see. The stem cells, are generally not affected by the treatment that destroys the soldiers. 29:53 Cancer stem cells have the ability to recruit and program normal cells. The harder we hit the cancer soldier stem cells with chemo radiation, the more the stem cells back away from the area and wait. 31:06 The strategy is to keep cancer stem cells happy and quiet. 33:44 A very low carb or keto diet was a common link in cancer patients that did the best with their therapies, longer remissions or no recurrence. 37:13 Research has found that integrative cancer therapies extended lifespan, compared to only standard therapy. 41:29 Work with at least two practitioners to get many options and varied care. 49:07 By the time we can see a cancer tumor with imaging, it has been growing slowly for 5 to 10 years or longer. 51:00 Prescreening tests are getting better. Next generation testing, which still has some gaps, looks for things like circulating cancer cells. 52:06 Some traditional testing of non-specific inflammatory markers show metabolic shifts to an inflammatory milieu or a milieu that shows Warburg Effect. 58:38 Thermography, when done correctly, can detect and track cancer. 01:03:28 Dr. Anderson tests all cancer survivors for chronic infection, including the family of HHV, mycoplasma, c pneumoniae and more. 01:05:21 People who eat mushrooms regularly have lower rates of certain cancers. Some cancers that do not respond to anything else, will respond to mushrooms. 01:10:45 High protein intake and low quality protein sources can bring you out of cancer fighting mode and out of ketosis. Poor quality protein, and food in general, can bring toxins into your body. 01:14:18 The ideal morning routine for preventing cancer starts with a quiet mind and centering. Exercise in the morning for the brain and body. Hydrate. 01:18:27 Dr. Anderson would choose curcumin as his desert island supplement. Curcumin levels out cytokines and triggering molecules. 01:22:33 Dr. Anderson’s elevator pitch: keep people from developing cancer to is to get them to do the things that bring their metabolism back to its intended balance.
Our Scientific Director Megan Hall (née Roberts) recently had some of the work from her Master’s degree published in the journal Cell Metabolism, which is seriously impressive. The paper appeared on Science Daily, and generally caused a bit of a stir in the low carb community. As we have direct access to the horse’s mouth, I’ve asked Megan to join me in this episode of the podcast to summarise the findings and give some thoughts on how it might relate to human health. Here’s the outline of this interview with Megan Hall: [00:00:55] Mastermind Talks. [00:01:47] The lead up to the study. [00:02:17] Time-restricted feeding. [00:02:38] Are they eating longer because of a less crappy diet? [00:04:21] Calorie restriction was the focus of Megan's lab. [00:05:27] Stephen Phinney, MD, PhD and Jon Ramsey, PhD. [00:06:13] Study design. [00:07:36] High-fat diets in rodents. [00:08:39] Two arms: longevity and healthspan. [00:10:55] Grip strength in a rodent. [00:11:40] Novel object test. [00:12:55] fMRI for body composition using the EchoMRI. [00:13:13] The results. Study: Roberts, Megan N., et al. "A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice." Cell Metabolism 26.3 (2017): 539-546. [00:15:40] Valter Longo, PhD and USC Longevity Institute. Studies: Brandhorst, Sebastian, et al. "A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan." Cell metabolism 22.1 (2015): 86-99 and Wei, Min, et al. "Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease." Science translational medicine 9.377 (2017): eaai8700. [00:16:27] Study: Sleiman, Sama F., et al. "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate." Elife 5 (2016): e15092. [00:17:34] Motor function and coordination. [00:18:58] The importance of preserving type IIA muscle fibers. Podcast: The Most Reliable Way to Lose Weight with Dr Tommy Wood and The High-Performance Athlete with Drs Tommy Wood and Andy Galpin. [00:19:18] Study: Zou, Xiaoting, et al. "Acetoacetate accelerates muscle regeneration and ameliorates muscular dystrophy in mice." Journal of Biological Chemistry291.5 (2016): 2181-2195. [00:20:04] Exercise performance. [00:21:13] Physiologic insulin resistance. [00:22:06] Podcast: Real Food for Gestational Diabetes with Lily Nichols. [00:24:21] Keto vs low-carb. [00:27:05] Studies: β-Hydroxybutyrate: A Signaling Metabolite and Ketone bodies as signalling metabolites. [00:27:49] YouTube: Histone deacetylation and inhibition. [00:29:19] I mentioned the Khan Academy, but in the end Megan liked these videos on HDAC inhibitors and cancer and Histone deacetylation and inhibition (also mentions p53!). [00:30:49] FOXO proteins. [00:31:30] Lysine residues. [00:31:48] Mn SOD. [00:32:10] mTOR, Dr. Ron Rosedale. [00:34:04] REDD1 protein. [00:34:32] P53 protein, metformin. [00:35:30] Less cancer in KD mice. [00:36:00] Warburg Effect. [00:36:21] Replicability. [00:36:57] Study: Newman, John C., et al. "Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice." Cell Metabolism 26.3 (2017): 547-557. [00:38:28] Press coverage of the study, “Eat Fat, Live Longer” at Sciencedaily.com. [00:41:01] Soybean oil in rodent diets. [00:41:34] Sex-dependent differences. [00:43:23] Takeaways. [00:44:21] Dogma displacement inertia. [00:45:19] Exogenous ketones. Study: Stubbs, Brianna Jane, et al. "On the metabolism of exogenous ketones in humans." Frontiers in Physiology 8 (2017): 848. [00:46:34] What does this mean for humans? [00:47:42] Weightloss. [00:48:36] Micromanaging the details. [00:50:33] Who are you and what are your goals -- Robb Wolf. Podcast: Wired to Eat with Robb Wolf. [00:51:55] Nourish Balance Thrive Highlights Series sign up. [00:53:11] Megan's purpose. [00:53:39] Book: Find Your Why: A Practical Guide for Discovering Purpose for You and Your Team by Simon Sinek and David Mead.
It was an honor to have Dr. Dominc D'Agostino on our podcast since he was the one who inspired us to start Ketogeek in the first place. We have always looked up to him as a role model when it comes to researching, asking questions and consistently learning while at the same time helping educate the public. Bio: Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, cancer and performance. He was a crew member on NASA’s Extreme Environment Mission Operations 22 (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. Time Stamps: 3:36 - New in Dr. Dominic’s life and latest research going on 5:39 - Hyperbaric vs. Hypobaric & countermeasures against extreme environments 11:55 - Hyperbaric Oxygen Therapy and its various applications 13:54 – Biological mechanism behind Hyperbaric Oxygen Therapy for combating cancer 20:34 – How to determine frequency and pressure for Hyperbaric Oxygen Chamber? 21:52 – How to design a Ketogenic diet to be used for experimentation? 24:09 - Impact of Ketogenic diet in rodent models 27:00 – Comprehensive protocols and therapy designs to combat cancer 28:40 – How to take animal models and apply them to human therapy and clinical trials? 32:40 – Can computer models and machine learning help with simulating the growth of cancerous cells? 36:12 – Warburg Effect, metabolic approach and is there a relationship between genetics and cancer? 43:17 – Steps to take if I have cancer? 50:49 – Resources available from Dr. Dominic and promoting the role of nutrition and modern cancer therapies. 57:16 – Overcoming challenges when pushing paradigm shifting ideas in the world 1:00:06 – Inflammation and signaling effects of Ketones 1:03:25 – Tracking the right biomarkers to maximize the potency of a therapeutic ketogenic diet 1:09:48 – How NEEMO 22 (NASA Extreme Environment Mission Operations) simulates an extreme environment. 1:13:10 – Objectives carried out and biomarkers tracked during this operation 1:15:13 – Pitching the Ketogenic Diet against the NEEMO environment 1:16:00 – Routines, tasks and gadgets used to gather data for various researches 1:20:31 – Impact of NEEMO environment on inflammation, stress levels, sleep and task loading 1:22:14 – Objective prioritization and efficient multi-tasking in the extreme aquatic environment 1:27:54 – Dr. Dominic’s plug and recommendations Plugs: Website: https://ketonutrition.org/ Social Media accounts (Twitter/Instagram/SnapChat/Facebook): Facebook: https://www.facebook.com/dominic.dagostino.1 Twitter: https://twitter.com/DominicDAgosti2?lang=en Instagram: https://www.instagram.com/dominic.dagostino.kt/?hl=en Linkedin: https://www.linkedin.com/in/dominic-d-agostino-156014b/ Academia (research pubs): https://usf.academia.edu/DominicDAgostino Ketogeek has a massive sphere of influence with it's three pillars of 'Educate', 'Empower' and 'Innovate' and we highly recommend signing up to our newsletter to learn everything from our community news to our products to our latest session with world class educators! Sign up by clicking here!
Mohamed Soliman and Jim Dennis discuss an adaptor protein that decreases glucose uptake and metabolism by inhibiting mTOR signaling.
Dr. Cate Shanahan, author of Deep Nutrition and Food Rules, pulls no punches when discussing how our conventional view of screening and treating cancer could be ill-advised. Unsurprisingly, the “conventional” ways of viewing many things in our world do not hold up anymore - and this, of course, includes the food system, the hospital system, and most importantly, how we perceive health-care and the concept of sickness in this country. Could it be that we have actually gotten some crucial things wrong when it comes to how we view the screening and treatment process for cancer? If anyone would know, it’s Dr. Cate, as she has always been ahead of the game. Early on in her career, she had an epiphany that would change the course of her life: “My goal of making people healthy was not in alignment with the hospital’s goal, which was taking money out of sick people.” We once lived in a world where patients spent 90% of their doctor’s appointment simply talking to their doctor, but now, 90% of your appointment time is spent doing expensive tests! Still, Dr. Cate admits that when she first began her journey as a doctor, she naively believed that there had to be one hospital out there with a different way of doing things. Unfortunately, as we all know now, that’s just not the case. Thankfully, we have radical thinkers and pioneers in the medical field like Dr. Cate, who dedicate their lives to truly helping people heal. Referencing the work of Dr. Thomas Seyfried, Dr. Cate explains that cancer is actually a metabolic disease, rather than a genetic disease. This implies that instead of aggressive chemo and radiation treatment to attack cancer at the genetic level, dietary modification could be the most effective strategy. This aligns with the Warburg Effect principle, which suggests cancer cells feed preferentially on glucose, at a rate greater than regular cells. The idea is that starving cancer cells of glucose with fasting and ketogenic eating patterns makes it possible to shrink tumors and heal. To put it simply, metabolic diseases are most effectively treated through metabolic treatments. While it might be unsettling to rethink the template strategy of cancer fighting, Dr. Cate's commentary can help you reflect further about how your thoughts, beliefs, and food choices affect your overall health. Unfortunately, there are so many things that most people do in daily life, from certain lifestyle habits to not being aware that their salad dressing contains vegetable oil, that actually promotes cancer. There are so many hidden dangers lurking in this world, but luckily, Dr. Cate knows exactly what you need to do to protect yourself from them, so enjoy this discussion with one of the great leaders of the ancestral health movement, and be sure to read Deep Nutrition ( https://www.amazon.com/Deep-Nutrition-Your-Genes-Traditional/dp/1250113849/ref=sr_1_1?crid=2P1GKRK74W0S1&keywords=deep+nutrition+by+catherine+shanahan&qid=1574651628&sprefix=deep+nutrit%2Caps%2C274&sr=8-1 ) to learn the hows and whys about choosing the most nutritious foods that your genes expect for optimum health. *TIMESTAMPS:* How hospitals extract money from people [5:30]. It used to be that 90% of your appointment time was spent talking to your doctor, nowadays, 90% of your time is spent getting tests done [11:10]. The myth that catching cancer early on is better is not always true [16:45]. Metabolic problems need to be solved by metabolic treatments [21:40]. Why Dr. Cate feels like she is “cancer-proof” [28:30]. Familial and genetic diseases have a degree of penetrance, which is your chance of developing the disease [34:00]. The four foods that will give you everything you need [43:00]. 30-40% of the average person’s daily calories come from “non-food” sources, like vegetable oils, which actively promote cancer [47:25]. Support this podcast at — https://redcircle.com/the-get-over-yourself-podcast/donations Advertising Inquiries: https://redcircle.com/brands
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