Podcasts about conclusions based

Have you ever found yourself jumping to conclusions or making assumptions about a situation based on your emotions? We all have biases, and they can sometimes lead us down the wrong path. This is especially true when we let our emotions take over and guide our thinking. In this blog post, we will explore the risks of jumping to conclusions based on emotions and discuss ways to unpack our biases. Jumping to conclusions based on emotions can be harmful in many ways. For example, it can lead to misunderstandings, hurt feelings, and damaged relationships. If we assume we know how someone feels or what they mean without checking our assumptions, we might miss the mark completely. This can cause unnecessary conflict and damage our relationships. Another risk of jumping to conclusions based on emotions is that it can lead us to make poor decisions. When we let our emotions guide our thinking, we might overlook important facts or ignore evidence that contradicts our assumptions. This can lead to bad choices and negative outcomes. So, what can we do to avoid jumping to conclusions based on emotions? The first step is to recognize that we all have biases. We are all shaped by our experiences, beliefs, and values, and these things can influence our thinking in ways that we are not always aware of. Once we recognize our biases, we can start to unpack them and examine how they might be affecting our thinking. One way to unpack our biases is to practice mindfulness. Mindfulness is the practice of paying attention to our thoughts, feelings, and sensations without judgment. When we practice mindfulness, we can observe our emotions and thoughts without getting caught up in them. This can help us identify when we are making assumptions based on our emotions and allow us to pause and consider other possibilities. Another way to avoid jumping to conclusions based on emotions is to gather more information. Before making assumptions, we should try to get a fuller picture of the situation. This might involve asking questions, seeking out different perspectives, or doing research. The more information we have, the less likely we are to jump to conclusions based on our emotions. Finally, we should be open to feedback and willing to revise our assumptions. If someone points out that our assumptions are incorrect or incomplete, we should be willing to listen and reconsider our thinking. This can be challenging, as it requires us to let go of our ego and be open to learning and growth. But it is essential if we want to avoid the risks of jumping to conclusions based on emotions. In conclusion, jumping to conclusions based on emotions can be harmful in many ways. It can lead to misunderstandings, hurt feelings, damaged relationships, and poor decisions. To avoid these risks, we should recognize our biases, practice mindfulness, gather more information, and be open to feedback. By unpacking our biases and examining our assumptions, we can make more informed and thoughtful decisions that lead to positive outcomes. Please go to www.abqpodcast.com where you can get show notes, resources, and links to everything we talked about today to help you navigate your journey as an entrepreneur and business owner. Be sure to follow me on Instagram at @abqjasonrigby  or Twitter at @abqjasonrigby also don't forget to sign up for our email list where I drop exclusive business strategies & marketing secrets to help you and your business grow!

www.WrightChat.comWe answer and schedule your new patient phone calls either as your primary or backup - Stop using outdated answering services as nobody leaves voicemails anymore ... We speak just like your own employees, remote in and schedule new patients and they never know a "third party" answered! www.NewPatientGroup.com/FreeCourses At New Patient Group, we are more than just orthodontic practice consultants. We are a transformational coaching and digital marketing company bringing outside of orthodontics expertise to orthodontic practices wanting to thrive in the new economy. We come from outside your orthodontic practice “bubble” with real expertise in all the non-clinical skill sets you and your team must have to succeed in today's commoditized orthodontic industry. We are described by others as having an “underground cult following” with a client retention rate of over 98% and the biggest orthodontist names as clients while spending virtually nothing on advertising. We are founded by Brian Wright, a world-renowned expert in business growth, sales, customer service, and consumer psychology. He is also a trusted speaker for the finest companies in the world, including Invisalign, Henry Schein, Dental Monitoring, OrthoFi, and others. He has been described as a combination of the team from Shark Tank and Marcus Lemonis from The Profit. The best orthodontists in the world utilize our innovative coaching and marketing services to become better versions of themselves, streamline their practices, advance their careers, break through plateaus, improve conversion, increase new patients, and more!  Schedule a Free Consultation today and let us learn more about you, your orthodontic practice, and how we can customize something specific to your wants/needs. 

Suspicion: How not to jump to conclusions based on someone's statues update Guest Shahista Ebrahim by Radio Islam

In today's podcast we discuss why we jump to conclusions. Basing our conclusions off fear and the "normal". Website: www.ritakaravias.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.23.309526v1?rss=1 Authors: Mazzetti, C., Gonzales Damatac, C., Sprooten, E., ter Huurne, N., Buitelaar, J. K., Jensen, O. Abstract: Background: While pharmacological treatment with Methylphenidate (MPH) is a first line intervention for ADHD, its mechanisms of action have yet to be elucidated. In a previous MEG study, we demonstrated that MPH in ADHD normalizes beta depression in preparation to motor responses (1). We here seek to identify the white matter tracts that mediate MPH's effect on beta oscillations. Methods: We implemented a double-blind placebo-controlled crossover design, where boys diagnosed with ADHD underwent behavioral and MEG measurements during a spatial attention task while on and off MPH. Results were compared with an age/IQ-matched typically developing (TD) group performing the same task. Estimates of white matter tracts were obtained through diffusion tensor imaging (DTI). Based on aprioristic selection model criteria, we sought to determine the fiber tracts associated with electrophysiological, behavioral and clinical features of attentional functions. Results: We identified three main tracts: the anterior thalamic radiation (ATR), the Superior Longitudinal Fasciculus (parietal endings) (SLFp) and Superior Longitudinal Fasciculus (temporal endings) (SLFt). ADHD symptoms severity was associated with lower fractional anisotropy (FA) within the ATR. In addition, individuals with relatively higher FA in SLFp compared to SLFt showed faster and more accurate behavioral responses to MPH. Furthermore, the same parieto-temporal FA gradient explained the effects of MPH on beta modulation: subjects with ADHD exhibiting higher FA in SLFp compared to SLFt also displayed greater effects of MPH on beta power during response preparation. Conclusions: Based on MPH's modulatory effects on striatal dopamine levels, our data suggest that the behavioral deficits and aberrant oscillatory modulations observed in ADHD depend on a structural connectivity imbalance within the SLF, caused by a diffusivity gradient in favor of temporal rather than parietal, fiber tracts. Copy rights belong to original authors. Visit the link for more info

Conclusions based on flawed assumptions are ultimately flawed conclusions. That makes sense. But when governments are involved, they don’t seem to adhere to that basic law of nature. Real estate developers will soon have to create or fund social and affordable housing if they want to build in Montreal. Projet Montreal passed a new housing bylaw in June of this year, following through on a campaign promise to give Montrealers more affordable housing. The new bylaw aims to regulate the real estate market and improve upon its current vacancy rate of 1.9 per cent, the lowest in years. Developers would have to enter into an agreement with the city to build affordable and social housing units, and family housing units, or give land to the city or make a financial contribution in lieu of building the finished units. The Mayor is hoping to get land for free out of the new rules. On a big project for example in downtown Montreal, The Mayor hopes it's going to be more interesting financially for developers to give the city land so the city can develop social and affordable housing. The number of units required to be social, affordable or family will depend on how many are being built overall and the location in the city. For example, for a building with 50 or more units downtown, a developer would have to build: - social housing equal to 20 per cent of the project - affordable housing equal to 10-15 per cent of the project - family housing equal to 5 per cent of the project The city expects condo prices to rise by 2 to 4 per cent because of the bylaw. I have to tell you that as a developer, it’s increasingly difficult to make the numbers work in today’s environment. This is simply based on the rising cost of construction, increased taxes and levies from government. For example, the development charges from the city have been steadily increasing and growing much faster than the rate of inflation. Only a few years ago, the federal government significantly reduced the value added tax rebate on new construction. This means that a developer needs to charge a 13% sales tax on the sale price of a new property. There is a small rebate, but most of the tax gets passed onto the end-buyer. Since the resale market has not gone up by 13% to compensate for this, it has had the impact of reducing or outright eliminating the profit margin for developers who build new housing. The industry still has not fully absorbed the additional tax. Many builders have exited the business entirely because the numbers no longer make sense. The smaller number of builders has created increased competition for fewer resources in the construction industry, which in turn has increased labor costs for construction. If we now have to build a significant proportion of the project that will introduce a loss and negative cash flow, the number of viable projects will decline. What government officials fail to recognize is that investment money has no geographic restriction. People who live in a geographic area don’t want to move. They are often anchored in their community. Money has no such restriction. The greater Montreal area is made up of several municipalities. If prices in the downtown are going to go up by 5% to accommodate this new bylaw, some will simply choose to live in one of the neighbouring communities. The truth is that if you take 1/4 of a project and make it unprofitable, you need to compensate for that in other parts of the project. My financial models show that the real impact to maintain parity would require a price increase of 10% on the remaining units in order to make a project viable with the loss of profit from the affordable units. This is yet another example of government using flawed math to justify their position. Conclusions based on flawed assumptions are ultimately flawed conclusions.

Background: Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer characterized by complex aberrant genomes. A fundamental goal of current studies is to identify those somatic events arising in the variable landscape of PDA genomes that can be exploited for improved clinical outcomes. Methods: We used DNA content flow sorting to identify and purify tumor nuclei of PDA samples from 50 patients. The genome of each sorted sample was profiled by oligonucleotide comparative genomic hybridization and targeted resequencing of STAG2. Transposon insertions within STAG2 in a KRAS(G12D)-driven genetically engineered mouse model of PDA were screened by RT-PCR. We then used a tissue microarray to survey STAG2 protein expression levels in 344 human PDA tumor samples and adjacent tissues. Univariate Kaplan Meier analysis and multivariate Cox Regression analysis were used to assess the association of STAG2 expression relative to overall survival and response to adjuvant therapy. Finally, RNAi-based assays with PDA cell lines were used to assess the potential therapeutic consequence of STAG2 expression in response to 18 therapeutic agents. Results: STAG2 is targeted by somatic aberrations in a subset (4%) of human PDAs. Transposon-mediated disruption of STAG2 in a KRAS(G12D) genetically engineered mouse model promotes the development of PDA and its progression to metastatic disease. There was a statistically significant loss of STAG2 protein expression in human tumor tissue (Wilcoxon-Rank test) with complete absence of STAG2 staining observed in 15 (4.3%) patients. In univariate Kaplan Meier analysis nearly complete STAG2 positive staining (> 95% of nuclei positive) was associated with a median survival benefit of 6.41 months (P = 0.031). The survival benefit of adjuvant chemotherapy was only seen in patients with a STAG2 staining of less than 95% (median survival benefit 7.65 months; P = 0.028). Multivariate Cox Regression analysis showed that STAG2 is an independent prognostic factor for survival in pancreatic cancer patients. Finally, we show that RNAi-mediated knockdown of STAG2 selectively sensitizes human PDA cell lines to platinum-based therapy. Conclusions: Based on these iterative findings we propose that STAG2 is a clinically significant tumor suppressor in PDA.

Background: Deregulation of Wnt/beta-catenin signaling is a hallmark of the majority of sporadic forms of colorectal cancer and results in increased stability of the protein beta-catenin. beta-catenin is then shuttled into the nucleus where it activates the transcription of its target genes, including the proto-oncogenes MYC and CCND1 as well as the genes encoding the basic helix-loop-helix (bHLH) proteins ASCL2 and ITF-2B. To identify genes commonly regulated by beta-catenin in colorectal cancer cell lines, we analyzed beta-catenin target gene expression in two non-isogenic cell lines, DLD1 and SW480, using DNA microarrays and compared these genes to beta-catenin target genes published in the PubMed database and DNA microarray data presented in the Gene Expression Omnibus (GEO) database. Results: Treatment of DLD1 and SW480 cells with beta-catenin siRNA resulted in differential expression of 1501 and 2389 genes, respectively. 335 of these genes were regulated in the same direction in both cell lines. Comparison of these data with published beta-catenin target genes for the colon carcinoma cell line LS174T revealed 193 genes that are regulated similarly in all three cell lines. The overlapping gene set includes confirmed beta-catenin target genes like AXIN2, MYC, and ASCL2. We also identified 11 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that are regulated similarly in DLD1 and SW480 cells and one pathway - the steroid biosynthesis pathway - was regulated in all three cell lines. Conclusions: Based on the large number of potential beta-catenin target genes found to be similarly regulated in DLD1, SW480 and LS174T cells as well as the large overlap with confirmed beta-catenin target genes, we conclude that DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study Wnt/beta-catenin signaling and associated colorectal carcinogenesis. Furthermore, the confirmed and the newly identified potential beta-catenin target genes are useful starting points for further studies.

Objective: Unplanned readmission of hospitalized patients to an ICU is associated with an increased mortality and hospital length of stay. The ability to identify patients at risk, who would benefit from prolonged ICU treatment, is limited. The aim of this study is to validate a previously published numerical index named the Stability and Workload Index for Transfer in a heterogeneous group of ICU patients. Design: In this retrospective data analysis, the Stability and Workload Index for Transfer score was calculated for all patients, and the ability of the score to predict readmission was compared with the original publication. Setting: Four ICUs, one intermediate care unit, and one postanesthesia care unit of the department of anesthesia and intensive care of a university hospital. Patients: All consecutive patients treated in one of the units. Interventions: None. Measurements and Main Results: Unplanned ICU readmissions or unexpected death within 7 days of ICU discharge. The data of 7,175 patients were included in the analysis. Five hundred ninety-six patients were readmitted or died within 7 days of discharge. The patients who are readmitted to the ICU are significantly older and have significantly higher scores that define the severity of disease at the time of admission and discharge of their first ICU stay. The source of admission for the initial ICU stay did not differ (p = 0.055), and the last Glasgow Coma Scale and the last Pao(2)/Fio(2) ratio before discharge from the ICU were higher in patients who did not need a readmission to the ICU. The performance of the Stability and Workload Index for Transfer score is poor with an area under the receiver operator curve of 0.581 (95% CI, 0.556-0.605; p < 0.001). Conclusions: Based on the data from our patients, the proposed Stability and Workload Index for Transfer score by Gajic et al is not ideal in aiding the clinician in the decision, if a patient can be discharged safely from the ICU and further research is necessary to define the patients at risk for readmission.

Background: The duration of protection after hepatitis B vaccination in early infancy is unclear and may be related to vaccination schedule, dosage, vaccine type and population characteristics. Factors potentially influencing waning immunity were assessed. Methods: A systematic review was performed. The main outcomes were prevalence of anti-hepatits B antibodies >= 10 mIU/mL after primary or booster vaccination. Factors potentially influencing protection were assessed in an adjusted random-effects meta-analysis model by age for both outcomes. Results of both meta-analyses were combined in a prognostic model. Results: Forty-six studies reporting on the anti-hepatits B antibodies >= 10 mIU/mL 5 to 20 years after primary immunization and 29 on booster response were identified. The adjusted meta-analyses identified maternal carrier status (odds ratio OR]: 2.37 1.11; 5.08]), lower vaccine dosage than presently recommended (OR: 0.14 0.06; 0.30]) and gap time between last and preceding dose of the primary vaccine series (OR: 0.44 0.22; 0.86]) as determinants for persistence of anti-hepatits B antibodies >= 10. A lower vaccine dosage was also associated with failure to respond to booster (OR: 0.20 0.10; 0.38]). The prognostic model predicted long-term protection of 90% 77%; 100%] at the age of 17 years for offspring of noncarrier mothers vaccinated with a presently recommended dose and vaccination schedule. Conclusions: Based on meta-analyses, predictors of waning immunity after hepatitis B vaccination in infancy could be identified. A prognostic model for long-term protection after hepatitis B vaccination in infancy was developed.

Background: Ehrlichia species are the etiological agents of emerging and life-threatening tick-borne human zoonoses that inflict serious and fatal infections in companion animals and livestock. The aim of this paper was to phylogeneticaly characterise a new species of Ehrlichia isolated from Rhipicephalus (Boophilus) microplus from Minas Gerais, Brazil. Methods: The agent was isolated from the hemolymph of Rhipicephalus (B.) microplus engorged females that had been collected from naturally infested cattle in a farm in the state of Minas Gerais, Brazil. This agent was then established and cultured in IDE8 tick cells. The molecular and phylogenetic analysis was based on 16S rRNA, groEL, dsb, gltA and gp36 genes. We used the maximum likelihood method to construct the phylogenetic trees. Results: The phylogenetic trees based on 16S rRNA, groEL, dsb and gltA showed that the Ehrlichia spp isolated in this study falls in a clade separated from any previously reported Ehrlichia spp. The molecular analysis of the ortholog of gp36, the major immunoreactive glycoproteins in E. canis and ortholog of the E. chaffeensis gp47, showed a unique tandem repeat of 9 amino acids (VPAASGDAQ) when compared with those reported for E. canis, E. chaffeensis and the related mucin-like protein in E. ruminantium. Conclusions: Based on the molecular and phylogenetic analysis of the 16S rRNA, groEL, dsb and gltA genes we concluded that this tick-derived microorganism isolated in Brazil is a new species, named E. mineirensis (UFMG-EV), with predicted novel antigenic properties in the gp36 ortholog glycoprotein. Further studies on this new Ehrlichia spp should address questions about its transmissibility by ticks and its pathogenicity for mammalian hosts.

Background: Blood gas analysis (BGA), including measurement of ionized calcium, is performed routinely in patients with end stage renal disease on renal replacement therapy, especially when using citrate for regional anticoagulation. After installation of a new blood gas analyzer (RAPIDpoint (R) 405; BGA), we observed lower ionized calcium concentrations in a few patients without signs of hypocalcemia, whereas calcium concentrations were normal using a standard laboratory method. Pseudohypocalcemia was of limited duration and correlated with the short-term intake of sodium perchlorate monohydrate (Irenat (R)). Methods: We prepared dilution series from whole blood samples and stock solutions of calcium and perchlorate with different concentrations of ionized calcium and perchlorate. Measurement of ionized calcium concentrations was performed using two different blood gas analyzers (RAPIDpoint (R) 405; BGA and Roche AVL 9180; standard laboratory method). Results: After addition of different amounts of perchlorate, significant lower ionized calcium concentrations were measured with BGA compared to the standard laboratory method using either preparations from whole blood samples or stock solutions. The addition of potassium or methylene blue known to complex perchlorate had no effect on the concentrations of ionized calcium measured with BGA. Using different mathematical methods, a calculation of the "real" ionized calcium concentration from the value measured with BGA was not possible. Conclusions: Based on our experiments, we confirm the hypothesis that perchlorate can influence the measurement of ionized calcium by BGA. As the effect depends on the ion selective electrode that is used, it is advisable to test the blood gas analyzer with calcium and perchlorate solutions.

Background: Several randomized trials have documented the value of radiation dose escalation in patients with prostate cancer, especially in patients with intermediate risk profile. Up to now dose escalation is usually applied to the whole prostate. IMRT and related techniques currently allow for dose escalation in sub-volumes of the organ. However, the sensitivity of the imaging modality and the fact that small islands of cancer are often dispersed within the whole organ may limit these approaches with regard to a clear clinical benefit. In order to assess potential effects of a dose escalation in certain sub-volumes based on choline PET imaging a mathematical dose-response model was developed. Methods: Based on different assumptions for alpha/beta, gamma 50, sensitivity and specificity of choline PET, the influence of the whole prostate and simultaneous integrated boost (SIB) dose on tumor control probability (TCP) was calculated. Based on the given heterogeneity of all potential variables certain representative permutations of the parameters were chosen and, subsequently, the influence on TCP was assessed. Results: Using schedules with 74 Gy within the whole prostate and a SIB dose of 90 Gy the TCP increase ranged from 23.1% (high detection rate of choline PET, low whole prostate dose, high gamma 50/ASTRO definition for tumor control) to 1.4% TCP gain (low sensitivity of PET, high whole prostate dose, CN + 2 definition for tumor control) or even 0% in selected cases. The corresponding initial TCP values without integrated boost ranged from 67.3% to 100%. According to a large data set of intermediate-risk prostate cancer patients the resulting TCP gains ranged from 22.2% to 10.1% (ASTRO definition) or from 13.2% to 6.0% (CN + 2 definition). Discussion: Although a simplified mathematical model was employed, the presented model allows for an estimation in how far given schedules are relevant for clinical practice. However, the benefit of a SIB based on choline PET seems less than intuitively expected. Only under the assumption of high detection rates and low initial TCP values the TCP gain has been shown to be relevant. Conclusions: Based on the employed assumptions, specific dose escalation to choline PET positive areas within the prostate may increase the local control rates. Due to the lack of exact PET sensitivity and prostate alpha/beta parameter, no firm conclusions can be made. Small variations may completely abrogate the clinical benefit of a SIB based on choline PET imaging.

BACKGROUND: Successful pregnancies require fine tuning of fibrinolytic activities in order to secure fibrin polymerization and stabilization of the placental basal plate as well as to prevent excess fibrin deposition in placental vessels and intervillous spaces. Fibrinolysis is tightly regulated by plasminogen activator inhibitor-1 (PAI-1). Endothelial PAI-1 synthesis is induced by angiotensin II, which is generated by angiotensin I-converting enzyme (ACE). METHODS: We studied the ACE deletion (D)/insertion (I) polymorphism and the PAI-1 4G/5G polymorphism in women with recurrent spontaneous miscarriages (RM). Both polymorphisms have been shown to be associated with ACE and PAI-1 expression levels respectively. A study group of 184 patients with a history of two or more consecutive unexplained spontaneous miscarriages was compared with a control group of 127 patients with uneventful term deliveries and no history of miscarriages. RESULTS: Our findings show: (i) homozygosity for the D allele of the ACE gene, which results in elevated PAI-1 concentrations and hypofibrinolysis, is associated with an elevated risk of RM; (ii) the combination of the D/D genotype with two 4G alleles of the PAI-1 promoter, which further increases PAI-1 plasma levels, is significantly more frequent in RM patients compared with controls. CONCLUSIONS: Based on these results, we recommend the incorporation of these two polymorphisms into the spectrum of thrombophilic mutations which should be analysed in individuals with recurrent spontaneous miscarriages. Patients homozygous for both the ACE D and PAI-1 4G alleles may benefit from the application of low molecular weight heparin as early as possible in the pregnancy in order to prevent uteroplacental microthromboses.

This is a new segment to the podcast. I wanted to watch Virginia's packline defense and instead got interested in the their new 5-0 free flowing read and react system that Coach Bennett learned from Division 3-St. Joseph's. This is a real quick look at the good and bad. Remember: Don't Jump to Conclusions Based on a Single Game! Youtube Clips are on Hoop Vision 68 courtesy of Jordan Sperber who also has an excellent podcast. FB and IG is WV Overtime, Twitter @OvertimeWV and email: WVOvertime@gmail.com Support this podcast at — https://redcircle.com/wv-overtime802/donations