Podcasts about Longitudinal

Interview with Leila J. Mady, MD, PhD, MPH, author of Longitudinal Financial Toxicity and Quality of Life in Head and Neck Cancer. Hosted by Paul C. Bryson, MD, MBA. Related Content: Longitudinal Financial Toxicity and Quality of Life in Head and Neck Cancer

Longitudinal trajectory of medial gastrocnemius muscle growth in the first years of lifeAim: To define the longitudinal trajectory of gastrocnemius muscle growth in 6- to 36-month-old children with and without spastic cerebral palsy (SCP) and to compare trajectories by levels of gross motor function (Gross Motor Function Classification System, GMFCS) and presumed brain-lesion timing.Method: Twenty typically developing children and 24 children with SCP (GMFCS levels I-II/III-IV = 15/9), were included (28/16 females/males; mean age at first scan 15.4 months [standard deviation 4.93, range 6.24-23.8]). Three-dimensional freehand ultrasound was used to repeatedly assess muscle volume, length, and cross-sectional area (CSA), resulting in 138 assessments (mean interval 7.9 months). Brain lesion timing was evaluated with magnetic resonance imaging classification. Linear mixed-effects models defined growth rates, adjusted for GMFCS levels and presumed brain-lesion timing.Results: At age 12 months, children with SCP showed smaller morphological muscle size than typically developing children (5.8 mL vs 9.8 mL, p < 0.001), while subsequently no differences in muscle growth were found between children with and without SCP (muscle volume: 0.65 mL/month vs 0.74 mL/month). However, muscle volume and CSA growth rates were lower in children classified in GMFCS levels III and IV than typically developing children and those classified in GMFCS levels I and II, with differences ranging from -56% to -70% (p < 0.001).Interpretation: Muscle growth is already hampered during infancy in SCP. Muscle size growth further reduces with decreasing functional levels, independently from the brain lesion. Early monitoring of muscle growth combined with early intervention is needed.

In this BJSM podcast, Dr Harvi Hart overview of the different types of body mass and body composition measurements, and they may impact common knee conditions, and what this means for clinicians, patients, and athletes. Harvi specializes in knee injuries and conditions, such as ACL injuries, patellofemoral pain, and osteoarthritis. Her research aims to develop targeted treatments that improve symptoms, mobility, and quality of life for individuals with knee conditions, using a combination of joint movement analysis, imaging, and clinical outcome measures. Links: Is body mass index associated with patellofemoral pain and patellofemoral osteoarthritis? A systematic review and meta-regression and analysis https://pubmed.ncbi.nlm.nih.gov/27927675/ Adiposity and cartilage lesions following ACL reconstruction: https://pubmed.ncbi.nlm.nih.gov/38631554/ Longitudinal changes in adiposity following anterior cruciate ligament reconstruction and associations with knee symptoms and function: https://pubmed.ncbi.nlm.nih.gov/38737984/ Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study https://pubmed.ncbi.nlm.nih.gov/31705199/

Do you know anyone who has extremely intense relationships—one minute totally in love with someone; the next, flying into a rage and calling them the worst person ever? It's possible that they have borderline personality disorder.Whatever that is. What is a “personality disorder”, anyway? How is one diagnosed? In this episode of The Studies Show, Tom and Stuart discuss a disorder that gets a lot of attention online, but which seems pretty tricky to define. And it's somehow both surprising and entirely predictable that Tom relates this disorder back to his favourite topic: the Reverend Thomas Bayes.The Studies Show is brought to you by Works in Progress magazine. On their Substack newsletter, you can find different styles of articles that aren't part of the main magazine, like this excellent walkthrough of nuclear power technology called “Nuclear Reactors for Dummies”. You can find that and much more at worksinprogress.news. Show notes* Mayo Clinic page on personality disorders* NHS page on Borderline Personality Disorder* Chimamanda Ngozi Adichie's 2021 essay “It is Obscene”* Tom's Unherd article on this controversy* 2009 paper on Dissociative Identity Disorder and its overlap with Borderline Personality Disorder* Comparison of patients with DID and BPD, with a discussion of the overlap* Pieces by people with BPD diagnoses who've regularly changed their dress/style* Tom's book on Bayesianism* Sceptical article about top-down effects on perception* Paper on the “predictive processing” theory of BPD* Scott Alexander article on the same topic* Twin study on the overlap between BPD and antisocial personality disorder, and potential sex differences* Longitudinal studies on whether people “age out” of BPD* People higher in “dark tetrad” traits are more likely to enjoy trolling people onlineCreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

This episode originally aired on October 1st, 2024. Dr. Rachel Quaney chats with Dr. Michael Keller and Dr. Burton Lee on their paper "Impact of Longitudinal Mechanical Ventilation Curriculum on Decay of Knowledge." 

Send us a textEpisódio 54 – Hipotermia, Crescimento, Infecção Metabólica e Nariz Eletrônico na NeonatologiaNeste episódio especial, apresentamos os destaques do Encontro Internacional de Neonatologia, realizado nos dias 4 e 5 de abril em Gramado, sob a mais uma vez brilhante organização dos professores Rita e Renato Procianoy. Um evento que reuniu especialistas do Brasil e do mundo para discutir os avanços mais recentes no cuidado neonatal — e nós não poderíamos deixar de compartilhar com vocês, ouvintes que acompanham quinzenalmente o nosso Journal Club em língua portuguesa.Selecionamos quatro estudos que marcaram as discussões científicas durante o encontro:1. Whole-Body Hypothermia vs Targeted Normothermia for Neonates With Mild Encephalopathy – Este ensaio clínico multicêntrico coloca em pauta uma pergunta que muitos de nós enfrentamos à beira do leito: recém-nascidos com encefalopatia leve devem ser resfriados?2. Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis-infected preterm newborns – Uma fascinante investigação experimental que conecta metabolismo energético e resposta inflamatória em prematuros infectados, com possíveis implicações clínicas na prevenção da disfunção orgânica.3.Monitoring the Postnatal Growth of Preterm Infants: A Paradigm Change – Este artigo propõe uma verdadeira mudança de paradigma na forma como monitoramos o crescimento de prematuros, destacando a importância de uma abordagem individualizada e centrada no bebê. 4. Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants– Um estudo que combina análise do microbioma e metabolômica para identificar marcadores precoces de enterocolite necrosante, uma das doenças mais temidas da neonatologia.Esperamos que este episódio especial amplie seu repertório científico e inspire práticas ainda mais seguras e baseadas em evidências. Se você gosta do nosso conteúdo, avalie o programa na sua plataforma de streaming e compartilhe com colegas e interessados. Seu apoio é essencial para continuarmos promovendo a neonatologia em língua portuguesa!Até o próximo episódio! Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Host Dr. Davide Soldato and guests Dr. Jessica Burris discuss the article "Longitudinal Results from the Nationwide Just ASK Initiative to Promote Routine Smoking Assessment in American College of Surgeons Accredited Cancer Programs" and how persistent smoking following cancer diagnosis causes adverse outcomes while smoking cessation can improve survival. TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Dr. Davide SoldatoHello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, medical oncologist at Ospedale San Martino in Genoa, Italy. Today we are joined by JCO author Dr. Jessica Burris. Dr. Burris is an Associate professor of Psychology at the University of Kentucky and co leader of the Cancer Prevention and Control Research Program at the Markey Cancer Center. Her research focuses on smoking cessation among cancer survivors, health disparities, and behavioral interventions to promote health equity. She also leads the BIRDS Lab, which explores the intersection of smoking, social determinants of health, and cancer survivorship. Today I will be discussing with Dr. Burris on the article titled Longitudinal Results from the Nationwide Just Ask Initiative to Promote Routine Smoking Assessment in American College of Surgeons Accredited Cancer Program. So, thank you for Speaking with us, Dr. Burris. Dr. Jessica BurrisThank you for inviting me. Dr. Davide SoldatoSo today we'll be discussing an important study on the implementation of smoking assessment in cancer care and specifically through the Just Ask Initiative. So, we know that tobacco use is a critical factor in cancer treatment outcomes in general, and yet integrating systematic smoking assessment into oncology care has faced various challenges. So, Dr. Burris, to start off our interview, I would like to ask you to briefly introduce the Just Ask Initiative for those of our readers and listeners who may not be familiar with it. So, a little bit about the primary goals and why do you think that routine smoking assessment is such an important aspect of cancer care and why the Just Ask Initiative focuses on this specific issue? Dr. Jessica BurrisSure. So, as you mentioned before, smoking is a really critical factor in terms of cancer care and cancer outcomes. It impacts a lot of things, from complications after surgery up into cancer mortality, but it also impacts patient's quality of life. Their pain may be more severe, they're more tired, their distress levels are higher. So, there's just a lot of different reasons why we need to understand and address smoking in the context of cancer care. But like you said too, there's a lot of barriers as well. But in order to effectively treat nicotine dependence and tobacco use, we really need to know who is currently smoking. And so that was really the driver for Just Ask, wanting to make sure that we are asking every person with cancer at their diagnosis and as they go through treatment, what their smoking history is, if they are currently smoking, which we usually consider to be any smoking or other tobacco use in the past 30 days, so that once we can identify that person, then we know who we need to help. Dr. Davide SoldatoThank you very much. That was very clear. And in terms of methodology, Just Ask was really a quality improvement type of initiative that involved the programs that were contacted and approached to participate in this type of initiative. And the methodology is pretty standard for this type of implementation science, which is the Plan Do Study Act methodology. So just a little bit of background on this type of methodology and why do you think it might be so successful when implementing these types of changes at the structural level and when we are implementing these types of programs. Dr. Jessica BurrisRight. So, the American College of Surgeons requires all the accredited cancer programs, both Commission on Cancer and the NAPBC or the ones that focus on breast cancer, to do at least one quality improvement project annually. And most of the programs do use the evidence-based Plan Do Study Act approach. I think it's a great one. It has a lot of evidence behind it, but it also is very practical or pragmatic. So, you're using data from your local healthcare system or clinic or program to inform what it is that you do. And then you're constantly pulling data out to see how well you're addressing the clinical practice change that you're hoping to achieve. And so, data is going in and coming out and you're using that to inform exactly what it is that you're doing over time. So, it's an iterative approach to practice change and again, one that has proven successful time and time again. And so that's the program that these programs and Just Ask used in order to increase the frequency by which they ask patients about smoking. Dr. Davide SoldatoSo as you were saying, the main objective of the initiative was really to understand if we are asking patients diagnosed with cancer and survivors if they are smoking. And how can we better report this information inside of the medical chart of the patient. So, what was the primary endpoint or the objective that you had for this type of intervention? And can you give us a little bit of results? So, what did you find the implementation of this quality improvement? How did it change the percentages of patients that were asked about smoking habits? And a little bit, what is your opinion on the results that you obtain in the study? Dr. Jessica BurrisSure. So, the goal was simple and that was to have an ask rate that was at least 90%. The way that we defined an ask rate is among all newly diagnosed cancer patients, how many were asked about their smoking history and their current status at that initial visit? And so, we wanted all of the participating programs who opted in to Just Ask in 2022 to achieve that 90% ask rate by the end of this one-year quality improvement project. And again, using the Plan Do Study Act approach, it was a very pragmatic study in some ways. So, what we did was we provided an intervention change package that we made available online. And programs could access that whenever they needed to and pull-down educational resources, patient facing materials, practical tools for changing the EHR or pulling data out of the EHR, any of those number of things. And then we also hosted webinars over the course of the year. And those webinars were great because half the time they were in response to questions that programs were asking as they went through the Just Ask QI project. And the other half of time we were really just reminding programs of the rationale and the reason for making sure that they're asking. And then of course, letting them know that they don't have to stop there, they should be advising patients to quit and assisting them with cessation. Even though that wasn't the goal of Just Ask, the goal again of Just Ask was getting that 90% rate. And so, we had over 750 programs who opted in to Just Ask and did this QI study with us, and it was successful. So, we met the goal, or rather the programs met the goal of that 90% ask rate. And that was maintained over time. And that was just fantastic. So again, we know that the end goal is really to assist patients with quitting, but we can't do that unless we know who to help. And so, you have to ask first. And again, they were able to do that. Dr. Davide SoldatoSo thank you very much. The quality improvement program was absolutely successful. And to go a little bit in the numbers, by the end of the one-year implementation of the program, you report a 98% rate of asking patients who first approached the centers or over time if they were or not smokers. So, you said before that you targeted a 90% ask rate in terms of smoking habits. But when looking at the data, I noticed that you already had in the baseline survey where you asked the programs about what were the practice before the implementation of the Just Ask initiative, already something that was quite close to the 90%. And yet, despite starting from such a good point, which was basically your endpoint, you still observed a major change over the years of the implementation. So, I wanted to just underline a little bit what is the value of this type of programs. And still starting from such a very high standard still, we managed to further improve. And as you were saying, this is pivotal and I think it's fundamental to really understand and see who are the patients that we need to refer and then to help in the smoking cessation. So, I just wanted a little bit of a comment on these very important results, despite already starting from a very good background from the centers. Dr. Jessica BurrisYeah, I'm glad that you brought up the baseline. So, I think one thing that's important about this study is that we looked at our ask rate or the asking as a clinical practice in two different ways. So, the 98% that you referred to that we found at the final survey is based on a response to a question on the frequency of asking. So, it's a Likert type question. And essentially what we did was we combined programs that reported usually asking or almost always asking into one, and that's where we arrived at the 98%. And at baseline it was 92%. What's interesting though is that we also asked them to report the specific number of patients who were seen in their cancer program during the prior six months and the number of patients who were asked about smoking in the prior six months. And with that we could get a proportion. And in every case, the self-report Likert question had a higher outcome than the raw data based on the data that was pulled from the EHR. And so, we saw this increase significantly over time, both in the self-report Likert question, but also in the EHR based data. And so, it was a win in two ways. What I think is really interesting though is that at baseline, even though 92% of programs said that they regularly ask about their patient smoking status, 16% of programs could not provide data that would allow calculation of an ask rate. So, they were reporting that they were able to do so but then could not actually do so. So, I think what that means essentially is that there's a disconnect between what programs are doing regularly or they believe that they're doing regularly and what their data actually shows. And it could be an issue with the quality of the data that's going into the EHR, or it could be an issue with pulling the data out of the EHR. And so one of the things that we saw that I think is a second indicator of success of Just Ask is that the quality of the data that programs were inputting into the EHR related to their patients smoking history and smoking status did improve over time, which meant that by the end it really was the case that the vast majority of programs were asking. And not only that, but they were also documenting it in a way to where it could inform patient care. Does that make sense? Dr. Davide SoldatoAbsolutely. And I think that that explanation really is truly important because I think that it also connects a little bit to how the initiative was able also to change things at the structural level, to be sure that there was the best possible way of asking, but also of having that information readily available inside of the EHR. This also connects a little bit to my next question, which was a little bit about organizational structure and also implementation barriers, which you report also as a self-reported information by the specific programs. So, there was a little bit of implementation barriers that was reported by the programs and this was not a specific endpoint of the Just Ask initiative, but you kind of mentioned it a little bit. The difficulties in pulling data from the EHR in understanding whether the information was collected and how it was collected. This might be one of the implementation barrier when we are looking at initiatives like Just Ask. So, I just wanted a little bit of your opinion if you think that these implementational barriers are more on the organizational side or on the provider side. And how can we use these quality improvement programs to really tackle this type of barriers to improve overall the reach and the importance of our action regarding smoking cessation. Dr. Jessica BurrisThe devils in the details, right? So I think it's a “both and” situation and not either or I think for providers, for individual providers, oncologists, nurses, supportive care providers, the issue of feeling like they're not fully trained in tobacco use assessment and treatment, and also feeling because of a lack of training that they don't feel confident or competent or even comfortable having conversations with their patients about their smoking history or being in the position to where they can really help someone who wants to quit in choosing the best path and way forward to do that that really matters. And so organizational readiness, these programs that participated were pretty high even at baseline in terms of the organizational readiness. They understood that it's a problem and they wanted to do something about it. And they were really eager and chomping at the bit to do so. But that has to trickle down to individual providers. And so, I think one of the implementation strategies that was used was staff training and provider education. And a lot of the participating programs chose that strategy. And I think as staff and providers are trained in how to ask and how to do so in a way that is nonjudgmental and that doesn't lean into things like stigma or blame or making patients feel guilty that perhaps their behavior led to their cancer, but really just understanding tobacco history and understanding nicotine dependence and the best strategies that we have to address those things that helped and that made a difference but it also is things at the system level, like having good EHR data, being able to pull those data out at a regular interval every three months or every four months, or even every six months to make sure that you're tracking smoking and also quitting over time. Both of those things need to happen. And I think those were things that we saw change as a result of Just Ask participation. Dr. Davide SoldatoRelating to this, provider readiness also to counsel patients on how to stop smoking or what is the best strategy. Despite, as you said in the very beginning, this was not the objective of Just Ask because you just wanted to improve the rate of smoking assessment and the quality of reporting of smoking assessment. You still observed higher rates of patients and survivors that were actually referred to some kind of intervention for smoking cessation. So, I was just wondering, why do you think that even though that was not required, you still observe this type of improvement? Like, is it just inherent to the fact that we are improving and we are placing more interest and more attention on the fact that patients should quit smoking, or do you think that it relates to something else completely? Dr. Jessica BurrisI think there's probably multiple things going on. One is once you're fully aware of the fact of the impact of smoking after a cancer diagnosis, you're going to be compelled to do something, I think. And so just the simple fact of knowing now that the patient sitting in front of you has smoked in the past week or two, they may be under a lot of stress because they're coping with cancer and they're coping with the side effects of their treatment. They may even have increased their smoking since their cancer diagnosis. And now you have this information. I think people who are providing cancer care, they want to improve the health and the life of the person sitting in front of them. And if they understand that smoking is a detriment or a hurdle to their doing so, then they're also more inclined to try and help that person quit smoking. And so, I think the asking and the documenting likely led to an increase in assistance and referrals to tobacco treatment specialists or to a state quit line, which was also common, simply because that's part of providing quality care. I think also there's been a greater emphasis nationally, in part led by the National Cancer Institute and a cancer moonshot initiative that it led, they're really focused on getting more treatment to more patients with smoking and increasing the reach and the effectiveness of the treatments that we provide. And so, I think there has been a shift in oncology care broadly to put more attention on smoking and smoking cessation as part of standard cancer care. And so, I think this kind of shift in the field also informed things as well as, again, thinking about the patient and the individual who's in the room and wanting to do something about the problem that you've just identified. Dr. Davide SoldatoAnd one thing that I believe is truly exceptional about the Just Ask initiative is really also the diversity of the type of programs that you involved. Like, you went from community centers to more academic centers. And really, I did not have the impression reading the manuscript that there was any difference in the way this type of quality improvement initiative can really benefit all these programs and all these centers. So, I was just wanting to have your opinion or comment on how do you think this type of initiative could be transferable across the country and across different settings and different types of cancer care? Dr. Jessica BurrisYeah, I'm really glad that you brought that up, because I think most of the clinical trials that are done in this area are done at academic medical centers, which are admittedly kind of resource rich places to receive cancer care. And so, what works in academic medical center may not work in a small rural practice in the middle of Kansas, for example, or in Mississippi. And it may not work in other community-based practices, even if they're larger and set in an urban setting. And so, one of the things that frankly I loved about Just Ask is that it was very heterogeneous in terms of the sites and the participating groups. And so not only was it national and by far the largest initiative in this area, again with over 750 different programs, but the programs were diverse. So, we had large community-based programs, integrated networks, smaller community programs. And then the academic centers were actually the smallest. Only like 10 or 12 out of the 750 plus were academic. And so, it was very different than what is the norm in this research area and in this area generally in terms of clinical practice. And we were able to show that the type of program that participated had no bearing on their success. And so, when we think about initiatives that work and interventions that work, we also really have to think about what is scalable and what could be disseminated across different practices. And this is one of those things that can. It worked and it worked across different swaths of group, which was great. Dr. Davide SoldatoAbsolutely. And just one last comment about the intervention, and it's also a point that you raised in the manuscript. This initiative, like many others also at the national levels that have been reported previously, they rarely had really the participation or the perspective of the patients embodied inside of them. So, I was wondering, how do you see the field moving forward. Like you envision something that would implement sort of a co-creation with patients or cancer survivors in order to really create something that is more appealing and takes more into consideration what is the patient perspectives when we are approaching something like smoking cessation, which as you were mentioning before, it can have a lot of stigma or already some negative feelings by the patients and feelings of guilt regarding the fact that they smoked and that might have caused that cancer. So just a little bit of your opinion as to how you see the implementation science in smoking cessation moving forward while integrating also the patient perspectives. Dr. Jessica BurrisYeah, that's a great question. So, this is something that I've thought about a lot in my lab and at Market Cancer center, which I'll use as an example. But oftentimes what we see is that even when tobacco treatment is offered as part of standard cancer care, even when we try to remove barriers like the financial cost of treatment at Markey, we embed it within our psych oncology program. And so, all of those services are offered for free. The rate at which patients say, yes, they want to engage in treatment is much, much lower than what we would want. And so that means two things. One, we need to offer help repeatedly to patients and understand that their willingness to quit and their willingness to accept treatment likely would change over time. And so, we need to keep coming back to people. It's not a one and done situation. But then also we need to understand what the barriers are from a patient's perspective. So why are they saying no? That they're either not ready or that they don't want treatment. They want to, quote, unquote, go it alone. And oftentimes what we hear is that patients want to be able to do this by themselves. They want to feel like, I quit smoking and I did it all by myself. And this is this huge thing that I've overcome. Not too different from the perspective that a lot of patients have about fighting cancer. They want to fight this addiction, this dependence that they've had oftentimes for multiple decades. And so, I think one thing that might be beneficial is to think about having peer led tobacco treatment. So have a patient who was able to quit successfully and have them provide counseling alongside a trained provider so that patients see someone like them who's went through it in the context of cancer care and who was able to overcome and to fight and win against tobacco, essentially. I think the other thing is trying to make sure that when we're asking about smoking and when we're offering treatment that we are not accidentally harming patients by bringing up feelings of stigma or guilt or shame. And I think one way to make sure we don't do that is to really lean on clinicians who are trained in addressing social determinants of health and other supportive care. So, our social workers, I think would be great. They're oftentimes embedded within oncology care. They are surely able to be trained as tobacco treatment specialists. They're already working with patients; they're addressing other barriers to care. They're sensitive in how they ask questions oftentimes. And so, they're really an ideal partner for this work. And we have found in a lot of settings that social workers are great in terms of being tobacco treatment specialists, including what we saw in Just Ask. Dr. Davide SoldatoThank you very much. That was really very, very interesting. And so, last question, moving forward, we improved the rate of asking patients. We are able to document this addiction more clearly in the EHR. So how do you see the field moving forward? In the manuscript, you speak a little bit about the Beyond Ask initiative. So just a little bit of a background about what is this initiative, what you are planning to do, and what do you think would be the best way to really act on this information that we are starting to collect in a better way and more frequently. Dr. Jessica BurrisYeah. So Beyond Ask really took everything that we did in Just Ask and amplified it. So instead of focusing on asking, we really said to make a difference and to improve cancer outcomes, ultimately patients need to be able to quit smoking. It's not enough that we know who is smoking, but that we help that individual or those groups of people quit. And so Beyond Ask had the goal to increase cessation assistance. So, either prescribing medication to help with smoking cessation, referring to a quit line, or another evidence-based program, or personally providing cessation counseling on site at that cancer program and to try and improve again within assistance. It was another one-year study, but we increased the frequency of surveys. I think we ended up with five total surveys. So, we were capturing two to three months at a time instead of a six-month period. And the data that we were capturing was very similar to what we did in Just Ask. And I can say we're still doing the data analysis, but it was another major success. So, with Beyond Ask, we had about 350 participating programs, many of whom not all, but many did participate in Just Ask. So, I think Just Ask kind of energized people around addressing the issue of smoking in their patient population. And again, they were really chomping at the bit to do more. And so, we offered Beyond Ask just after Just Ask. So Just Ask was 2022. Beyond ask was 2023. It ended in the spring of 2024. And again, another success. Dr. Davide SoldatoThank you very much. So, we are eager to see the results of this study. So that leads us to the end of this interview. So, thank you again, Dr. Burris for joining us today and speaking about your work. Dr. Jessica BurrisThank you. Dr. Davide SoldatoSo we appreciate you sharing more on the JCO article titled Longitudinal Results from the Nationwide Just Ask Initiative to Promote Routine Smoking Assessment in American College of Surgeons Accredited Cancer Program. If you enjoy our show, please leave us a rating and a review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcast. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.  

Cancer detection is long overdue for a revolution. Current screening methods miss too much, cost billions, and often lead to false positives. But what if we could catch cancer at the very first cell—before it ever becomes a threat? A breakthrough technology could make that possible. AI, continuous monitoring, and implantable devices are reshaping how we detect disease, moving beyond outdated methods toward real-time, 24/7 tracking. Imagine a future where cancer is stopped before it even starts. Is this the next big leap in medicine?

This is the Weight and Healthcare newsletter. If you like what you are reading, please consider subscribing and/or sharing!Content note: this piece will discuss research around binge eating, including behaviors and frequency. In part 1, we looked at the authors and methodology of a 2024 study called “Evaluating dietary restriction as a maintaining factor in binge-eating disorder” by Bartholomay et al., whose authors claim that the findings “challenge the assumption that dietary restriction maintains BE [binge eating] among all individuals with BED [Binge Eating Disorder]. Rather, results suggest that dietary restriction may be largely unrelated to BE maintenance in this population, and that reducing dietary restriction generally does not have the intended effect on BE frequency.”Too Long Didn't Read Version:When analyzing research, it's important to check to see if the research that the authors cite to support their claims actually does support their claims. In this case, these authors are drawing large, broad-based conclusions that would support a weight-centric/weight-loss paradigm based on small, short-term, and decades old studies that offer only weak conclusions. They are also completely ignoring the success of a weight-neutral intervention that is included in on of the studies they cite. Let's dig in!When I teach research analysis, I recommend checking something I call “The Do-Do's” which encompasses two questions: Do the citations support the claims? Do the study data support the results?In this part of our three-part analysis, we're going to examine the first question. Regular readers may have noticed me pointing out in my analyses how often the studies that are cited don't support the claims. In the case of this study, the question “do the citations support the claims” is particularly important since they are using them to bolster a very limited experimental design, so I've devoted this section to some examples.Bartholomay et al. claim:“randomized controlled trials conducted among individuals with overw*ight and ob*sity demonstrate that assignment to a low-calorie weight loss diet (e.g., 1200 calories per day) produced greater decreases in binge-eating symptoms than assignment to a wait list control group (Goodrick et al., 1998; Klem et al., 1997; Reeves et al., 2001).”What I want to note here is that the study authors have created a false binary between low calorie weight loss diets and wait list control group which would be bad enough. In this case, they've done so by blatantly ignoring the inclusion of a weight-neutral intervention in the very first study they cited.Let's look at the three studies they cited to, in theory, support this claim:The first study they cite is1998 Nondieting versus dieting treatment for overw*ight binge-eating womenG K Goodrick 1, W S Poston 2nd, K T Kimball, R S Reeves, J P ForeytDOI: 10.1037//0022-006x.66.2.363This study evaluated non dieting vs dieting treatment for what they described as “overw*ight binge-eating women.” There were 219 subjects and they were assigned randomly to diet treatment, non-diet treatment, or wait-list control (which is a form of control group in which participants are told that they were on a wait list for the intervention, while being offered no intervention.)The diet intervention was a restricted diet “reinforced with behavioral strategies” and the non-diet treatment was “therapy designed to help participants break out of their dieting cycles.” It involved 18 months of contact - 6 months of treatment followed by 26 bi-weekly maintenance meetings. They checked in on the subjects 6 months later and 18 months later and at both follow-up points the Binge Eating Scale of both the diet and non-diet group was significantly better than the weight list group and at 18 months both experienced weight gain. They concluded that “Results indicate that neither intervention was successful in producing short- or long-term weight loss.”I would suggest that this means that the weight loss intervention is a failure since its goal was weight loss and binge eating reduction but the non-diet intervention was a success since it's goal was to reduce binge eating disorder. I would also suggest that it may have been more effective if the therapy included more specific techniques to reduce binge eating.What it means for sure is that a higher-weight cis woman (the only group included in the sample and thus the only group we can draw conclusions about) who wants to reduce binge eating without risking the experience of another failed diet (and the physical and psychological risks that can come with it) would be best served by a non-diet approach.Second, they cite:1997 A descriptive study of individuals successful at long-term maintenance of substantial weight lossM L Klem 1, R R Wing, M T McGuire, H M Seagle, J O HillDOI: 10.1093/ajcn/66.2.239The study discusses the ridiculous National Weight Control Registry (NWCR) which I often use as a peak example of the embarrassingly poor methodology that gets passed off as research in the weight-centric paradigm. I've written about it in detail previously but the short story is that they collect commonalities among an incredibly small group of dieters (literally 10,000 out of what is estimated to be over a billion attmpts) and then make unsupportable claims about those commonalities. I am unclear why Bartholomay et al cited this since the only reference to binge eating disorders is two studies that happened to include those who binge that tracked the mean lifetime weight loss of participants in order to compare it to the mean lifetime loss claimed in the NWCR. Not only could I find no claim here about whether weight loss attempts impacted binge behaviors, what I did find was that:”20% of the sample indicated a worsening in time spent thinking about weight and 14% reported a worsening in time spent thinking about food.”I would argue that, being as generous as I possibly can, this study has nothing to do with the authors claims and, being a bit less generous, this could be seen as a bit of a refutation of the claims.And this is why we check the references. Finally they cite2001 Nutrient intake of ob*se female binge eatersR S Reeves 1, R S McPherson, M Z Nichaman, R B Harrist, J P Foreyt, G K GoodrickDOI: 10.1016/S0002-8223(01)00055-4In this very small, short study 46 cis women were given a behavioral self-management intervention (6 months of weekly, 1-hour classes taught by registered dietitians) and the other group was a wait list control group. The researchers wanted to measure any change in calories consumed, percentages of calories from fat, protein, and carbohydrates, grams of fiber per 1,000 calories and change in number of self-reported binge days.After 6 months they found no significant difference between nutrients in either group. The behavioral self management group reported a greater reduction in binge days than the control group.Their conclusion was quite weak, finding that “Our results suggest that collecting dietary information from participants identified with binge eating disorder is challenging. Dietitians who conduct behavioral weight management programs may require additional training in identifying and understanding the psychological characteristics of participants with binge-eating disorder.”For this conclusion to have merit, behavioral weight management programs would have to be effective and there is no research supporting that and plenty suggesting that it is not.Overall these studies are small, short term, and quite old. The most recent was conducted about 24 years ago. It makes me wonder if there really isn't more recent data, or if more recent data exists but didn't support their conclusion? Also, remember that Barholomay et al. claimed “randomized controlled trials conducted among individuals with overw*ight and ob*sity demonstrate that assignment to a low-calorie weight loss diet (e.g., 1200 calories per day) produced greater decreases in binge-eating symptoms than assignment to a wait list control group.”I think their claim is seriously overstated. First of all, they should have been clear that this was the case in short-term, small sample studies. They also failed to mention that a non-diet treatment also produced greater decreases in binge-eating symptoms than in weight list control group - I wonder why they left that out of everything?Ok, let's look at another claim from Bartholomay et al.. They claim that adolescent girls with BN (which they explain is “bulimia nervosa, a disorder characterized by both binge eating and extreme compensatory behaviors; American Psychiatric Association, 2013”) who were assigned to participate in a healthy dieting intervention promoting weight control through moderate reductions in caloric intake, exhibited greater reductions in binge eating than girls who were assigned to a wait list control group.The first issue here is the claim that there is any such thing as a “healthy dieting intervention.” This is, in fact, a claim and not a fact, and it requires evidentiary support, which they don't offer. They don't even offer a definition of “healthy” nor proof that this intervention is, in fact, healthy by any definition. Again as we often see in research propping up the weight loss paradigm the authors have substituted “just saying stuff” for anything resembling scientific precision. In this case they are repeating a mistake originally made in the 2006 study they are citing by Burton and Stice called “Evaluation of a healthy-weight treatment program for bulimia nervosa: a preliminary randomized trial.” This study included 85 cisgender female participants with “full- and sub-threshold bulimia nervosa” who were randomly assigned to a 6-session “healthy dieting intervention” or a waitlist control group and assessed after a 3 month follow up. Their conclusion was that “These preliminary results suggest that this intervention shows potential for the treatment of bulimia nervosa and may be worthy of future refinement and evaluation. Results also provide experimental evidence that dieting behaviors do not maintain bulimia nervosa, suggesting the need to reconsider maintenance models for this eating disorder.”In using this study to support their claim, Bartholomay et al seem to be heavily glossing over words like “preliminary” and “may be worthy.” Also, even if we believe the results (without a deep dive into them) the fact that people on diets can suppress binging (or report suppressing binging) over 9 months is a far cry from showing what impact that restriction has over the long term.Back to Bartholomay et al., they make another claim that“Importantly, although longitudinal studies indicate that self reported dietary restraint predicts the future onset of binge-eating symptoms (Field et al., 1999; Killen et al., 1994; Stice, 2001; Stice et al., 2002), these results stand in stark contrast with findings from experimental treatment studies testing the causal effect of dietary restriction and restraint on the maintenance of binge eating.”This is an odd claim that, to me, is made with far too much confidence/bias. Longitudinal studies look at a longer time period, often quite a bit longer, than experimental treatments. Bartholomay et al. do not have a method to determine whether any difference is due to experimental design or simply due to the fact that experimental treatment studies capture a much shorter time frame. If what is true is that people who are on diets can suppress binge behaviors short term, but that the restriction drives additional binge behavior long-term, then the longitudinal studies could be more accurate.Let me offer an example to help illustrate the issue: It takes from 10-40 years for symptoms of asbestos conditions to appear. Let's stay that a study claimed “Importantly, although longitudinal studies indicate that exposure to asbestos causes mesothelioma, these results stand in stark contrast with findings from [6 month - 1.5 year] experimental treatment studies testing the causal effect of asbestos on mesothelioma, which found no relationship.”If the effect takes longer to appear than the time over which the experiments are conducted, there is a significant risk of missing the effect. That effect may be identified by longitudinal studies.Overall, I don't think the studies they are citing come anywhere close to, as they claim:“challenge the assumption that dietary restriction maintains BE [binge eating] among all individuals with BED [Binge Eating Disorder]. Rather, results suggest that dietary restriction may be largely unrelated to BE maintenance in this population, and that reducing dietary restriction generally does not have the intended effect on BE frequency.”In part 3 we'll investigate to see if the rest of the article's data supports their conclusions. Did you find this post helpful? You can subscribe for free to get future posts delivered direct to your inbox, or choose a paid subscription to support the newsletter (and the work that goes into it!) and get special benefits! Click the Subscribe button below for details:Liked the piece? Share the piece!More researchThe Research PostMore resourcesThe Resource Post*Note on language: I use “fat” as a neutral descriptor as used by the fat activist community, I use “ob*se” and “overw*ight” to acknowledge that these are terms that were created to medicalize and pathologize fat bodies, with roots in racism and specifically anti-Blackness. Please read Sabrina Strings' Fearing the Black Body – the Racial Origins of Fat Phobia and Da'Shaun Harrison' Get full access to Weight and Healthcare at weightandhealthcare.substack.com/subscribe

In this week's episode Greg and Patrick explore both the challenges and the opportunities of age-period-cohort analysis when trying to understand the complexities of human behavior over time. Along the way they also discuss bachelor night, Dave Brubeck, pay phones, street lights, global nuclear war, lazy thinking, I'm not a crook, biking to grandmas, HMS Pinafore, the Beatles, aggressive mice, trash snakes, and getting high at A-Basin.Stay in contact with Quantitude! Web page: quantitudepod.org TwitterX: @quantitudepod YouTube: @quantitudepod Merch: redbubble.com

Host Paul Bryson, MD, MBA shares key findings from a longitudinal study revealing that otolaryngologists are the primary surgical specialists consulted for chronic cough. Learn how this condition, often disruptive to patient quality of life, necessitates a collaborative approach involving pulmonology, gastroenterology, and allergy/immunology.

小説家がアルツハイマー病に→作品に兆候はあったのか？　クリスティの文章などを調査　2011年の研究。　カナダのトロント大学に所属する研究者らが2011年に発表した論文「Longitudinal detection of dementia through lexical and syntactic changes in writing: a case study of three British novelists」は、小説家の文章におけるアルツハイマー病の言語学的な兆候を分析した研究報告である。

Join me for a summary of recent long-term research of resorbed teeth due to impacted canines. This podcast is based on an excellent lecture by Julia Naoumova delivered at last year's British Orthodontic Conference. Part 2 with focus on the prognosis of resorbed teeth from impacted canines, and follows on from part 1 with explored outcomes of open Vs closed exposures of impacted canines – see here for part 1.  Root resorption of incisors reported at 19-67% Erikson 2000 Walker 2005, Mitsea 2022Anna Dahlén and Julia Naoumova 2024 retrospective CBCT study n =27 incisorsMean   Follow-up average 9 years (5.5-14.6)Patient reported outcomesSurvival 100%Horizontal grade 3 moderate resorption n=17  (resorption inner dentine not involve pulp moderate)Horizontal grade 4 severe resorption n=12 (pulp exposed severe)Vertical grade 3+ severe resorption n=7 (resorption 2mm-1/3rd moderate)oVertical grade 4 extreme resorption n = 1  (resorption 1/3rd +)No significant difference in any grade of resorption long term of the following:Symptoms Mobility and ankylosisDiscolourationIncrease gingival pocketing but not clinically significant RR horizontal changes with time No change 81%Worse 4%Improve 15%RR vertical changes  with timeNo change 43%Worsen 57%Expected as had orthodontic treatment as wellPrevious research 1-23 years Survival 93-100% Falahat 2008 , Bjerklin 2011, Becker 2005, Jönsson 2007Jönsson 2007 showed grade 1 mobility when root length < 10mm Conclusion:Extraction of asymptomatic based purely on root resorption should be routinely performedPaper by Anna Dahlén and Julia Naoumova 2024 Longitudinal study of root resorption on incisors caused by impacted maxillary canines—a clinical and cone beam CT assessment https://doi.org/10.1093/ejo/cjae052

This episode features Moyke Versluis (Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands Graduate school of Social and behavioral sciences, Tilburg University, Tilburg, The Netherlands).   What is already known about the topic? Patients who are aware of their limited prognosis are more likely to be actively involved in advance care planning. Many patients with advanced cancer are unaware of their limited prognosis.   What this paper adds? More patients with advanced cancer become aware of their limited prognosis during their last year of life. Some patients do not want to know their prognosis, and their wish to not know their prognosis is persistent during their last year of life.   Implications for practice, theory, or policy It is important for physicians to recognise that the patients' perception of prognosis may change as the disease progresses and to invite patients to discuss their needs and wishes regularly. Although some patients may prefer not to know their prognosis, it remains important to respectfully explore their preferences and wishes for end-of-life care.   Full paper available from:     https://journals.sagepub.com/doi/full/10.1177/02692163241301220   If you would like to record a podcast about your published (or accepted) Palliative Medicine paper, please contact Dr Amara Nwosu: a.nwosu@lancaster.ac.uk

Welcome to the 25th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with senior author Dr Tanya Stojkovic of the Brain article entitled: Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis Dr Stojkovic discusses findings from an impressive longitudinal adult cohort of congenital myasthenia syndrome and important issues around accurate diagnosis of congenital myasthenic syndromes and use of electromyography and muscle biopsy. Check out the full article on the Brain website as part of the November 2024 issue: https://doi.org/10.1093/brain/awae124 This episode was co-hosted by David Michael and Roberto Bellanti,  edited and produced by Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.

In this episode of the Becker's Healthcare Podcast, Erika Spicer Mason sits down with Jason Comer, CEO of Health Recovery Solutions, to explore the evolving landscape of remote patient monitoring (RPM). They discuss how healthcare organizations are leveraging RPM for longitudinal care, the benefits for both providers and patients, and key considerations for effective integration. Tune in to learn how RPM is transforming the healthcare journey and what the future holds for this innovative technology.This episode is sponsored by Health Recovery Solutions.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Association of Longitudinal Change in Ambulatory Blood Pressure With Cognitive Decline in Older Adults

Join Dr. Steve Gard, editor-in-chief of the Journal of Prosthetics and Orthotics, as he talks with Philip Muccio, founder & CEO of AxioBionics, about his study on Neuromuscular Electrical Stimulation (NMES) and its impact on arm use in hemiparetic and hemiplegic patients. They explore the development of the Axiobionics Biosleeve, study findings showing increased arm movement over time, and how these results challenge traditional recovery expectations. The conversation also looks at future research and the potential of advanced technologies to improve patient outcomes.   Show notes JPO article: Longitudinal Retrospective Study of a Wearable NMES System to Determine the Effects on Arm Usage in Hemiparetic and Hemiplegic Patients   O&P Research Insights is produced by Association Briefings.

O que é herpes? Separe trinta minutinhos do seu dia e descubra, com Mila Massuda, quais são os tipos, formas de transmissão, sintomas e complicações desses vírus que acompanham a humanidade há milhares de anos.Apresentação: Mila Massuda (@milamassuda)Roteiro: Mila Massuda (@milamassuda) e Emilio Garcia (@emilioblablalogia)Revisão de Roteiro: Vee Almeida Técnico de Gravação: Caio de Santis (@caiodesantis)Editora: Lilian Correa (@_lilianleme)Mixagem e Masterização: Lívia Mello (@adiscolizard) Produção: Prof. Vítor Soares (@profvitorsoares), Matheus Herédia (@Matheus_Heredia) e BláBláLogia (@blablalogia) e Biologia em Meia Hora (@biologiaemmeiahora)Gravado e editado nos estúdios TocaCast, do grupo Tocalivros (@tocalivros)REFERÊNCIASBJORNEVIK, K. et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science, v. 375, n. 6578, 21 jan. 2022.DAVISON, A. J. et al. The Order Herpesvirales. Archives of virology, v. 154, n. 1, p. 171–177, 2009.JOHNSTON, C. et al. Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection. JAMA, v. 328, n. 17, p. 1730, 1 nov. 2022.UMBERTO ROSANI et al. Tracing the invertebrate herpesviruses in the global sequence datasets. Frontiers in Marine Science, v. 10, 14 jul. 2023.WALD, A. Effect of Condoms on Reducing the Transmission of Herpes Simplex Virus Type 2 From Men to Women. JAMA, v. 285, n. 24, p. 3100, 27 jun. 2001.

Epigenetics offers fascinating insights into how our genes are influenced by lifestyle and environmental factors. In this week's episode of the Everything Epigenetics podcast, Dr. Raffaele Teperino and I delve into groundbreaking research on epigenetic inheritance and how reproductive fitness impacts long-term health. From the transfer of epigenetic material during conception to the role of paternal health in childhood obesity and diabetes risk, we discuss how these factors shape generational health outcomes. You'll learn about: • The role of epigenetics in reproductive fitness and how it goes beyond reproductive capacity. • How sperm and eggs transfer more than just DNA, influencing offspring development through epigenetic material. • The surprising impact of paternal health at conception on childhood obesity and metabolic disorders. • The importance of lifestyle changes before conception to improve offspring health. • Practical insights into integrating epigenetics into preventive medicine and public health. Chapters: 00:00 Welcome & Introduction 01:09 Dr. Teperino's journey into epigenetics and its link to complex diseases. 03:56 Understanding reproductive fitness and its connection to epigenetics. 08:33 The transfer of epigenetic material from sperm to oocyte. 17:01 The role of paternal health in shaping offspring health risks. 24:07 Longitudinal studies on early-life risks of obesity and diabetes. 37:44 The overlooked role of seminal plasma in reproductive health. 42:00 The future of epigenetics: Neurodevelopmental disorders and preventive health. 45:32 Closing thoughts and where to connect with Dr. Teperino.Support the showWhere to Find Us:Instagram Twitter Facebook Follow us on:Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

Rent control is one of the most hotly debated housing policies, and also one of the most researched. Konstantin Kholodilin reviewed over 200 rent control studies, dating back decades and spanning six continents, and he joins us to give an overview of their results.Show notes:Kholodilin, K. A. (2024). Rent control effects through the lens of empirical research: An almost complete review of the literature. Journal of Housing Economics, 101983.Konstantin's massive database of rent control policies across the world: Longitudinal database of rental housing market regulations: 100+ countries over 100+ years.Kholodilin, K. (2020). Long-term, multicountry perspective on rental market regulations. Housing Policy Debate, 30(6), 994-1015.Wikipedia article on ‘kommunalka' (communal apartment).Fogelson, R. M. (2013). The Great Rent Wars: New York, 1917-1929. Yale University Press.Episode 36 of UCLA Housing Voice on rent control in India with Sahil Gandhi and Richard Green.Willis, J. W. (1948). State rent-control legislation, 1946-1947. The Yale Law Journal, 57(3), 351-376.

Commentary by Dr. Alena Shantsila.

In this episode of Admissions Straight Talk, host Linda Abraham interviews Dr. Jeffrey SooHoo, Assistant Dean for Admissions at the University of Colorado School of Medicine. They discuss the unique aspects of the Colorado medical curriculum, including the new Trek curriculum, the importance of longitudinal integrated clerkships, and the various tracks available for students. Dr. SooHoo also shares insights into the secondary application process, the role of the CASPER test, and the criteria for interview invitations. The conversation highlights common mistakes applicants make, the importance of research experience, and the support systems in place for medical students. Dr. SooHoo emphasizes the competitive nature of medical school admissions and the holistic review process used to evaluate applicants.Takeaways:The Colorado School of Medicine has a unique Trek curriculum launched in 2021.Longitudinal integrated clerkships allow for deeper relationships with preceptors and patients.Students can choose from various tracks, including rural medicine and global health.The secondary application focuses on value alignment with the school's pillars: leadership, curiosity, and commitment.CASPER is used to assess non-cognitive competencies in applicants.The admissions process is highly competitive, with many qualified applicants not receiving offers.Interviews are conducted virtually and include both group and individual assessments.Research experience is beneficial but not mandatory for applicants.Common mistakes include not understanding the competitiveness of admissions and failing to tell a cohesive story in applications.Support systems like Compass Guides help students navigate their medical education.Relevant Links:University of Colorado School of MedicineAccepted's Med School Calculator QuizRelated Shows:Washington University School of MedicineDeep Dive Into Duke Medical: An Interview with Associate Dean Linton YeeDuke's Physician Assistant ProgramGetting Into Med School Isn't Easy…But This Applicant Did It! Follow UsYouTubeFacebookLinkedInContact Uswww.accepted.comsupport@accepted.com+1 (310) 815-9553

Today, you'll learn about a new bacteria-busting polymer inspired by barnacles, how the things you do today will affect your brain in two weeks, and the memories elephants keep of their favorite people from long ago. Barnacle Polymers “Barnacle-inspired polymers could present new way to design antibiofilm materials, researchers say.” by Cynthia McCormick Hibbdrt. 2024. “Coacervate Dense Phase Displaces Surface-Established Pseudomonas aeruginosa Biofilms.” by Apoorva Vishwakarma, et al. 2024. Two Week Brain “Your Brain Changes Based on What You Did Two Weeks Ago.” by Pandora Dewan. 2024. “Longitudinal single-subject neuroimaging study reveals effects of daily environmental, physiological, and lifestyle factors on functional brain connectivity.” by Ana Maria Triana, et al. 2024. Elephant Memory “Do African Savanna Elephants (Loxodonta africana) Show Interspecific Social Long-Term Memory for Their Zoo Keepers?” by Martin Kranzlin, et al. 2024. “Truth or Tail: Elephants have good memories.” Cleveland Zoo Society. 2021. “Long-Term Olfactory Memory in African Elephants.” by Franziska Hoerner, et al. 2023. Follow Curiosity Daily on your favorite podcast app to get smarter with Calli and Nate — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. Hosted on Acast. See acast.com/privacy for more information.

Welcome to the Social-Engineer Podcast: The Doctor Is In Series – where we will discuss understandings and developments in the field of psychology.     In today's episode, Chris and Abbie are discussing Bullying. They will talk about what bullying is, the difference between bullying and just being mean and the psychological impact it can have on people, as well as what we can do about it. [Nov 4, 2024]    00:00 - Intro  00:16 - Dr. Abbie Maroño Intro  00:42 - Intro Links  Social-Engineer.com - http://www.social-engineer.com/  Managed Voice Phishing - https://www.social-engineer.com/services/vishing-service/  Managed Email Phishing - https://www.social-engineer.com/services/se-phishing-service/  Adversarial Simulations - https://www.social-engineer.com/services/social-engineering-penetration-test/  Social-Engineer channel on SLACK - https://social-engineering-hq.slack.com/ssb  CLUTCH - http://www.pro-rock.com/  innocentlivesfoundation.org - http://www.innocentlivesfoundation.org/   03:50 - The Topic of the Day: Bullying  04:17 - Defining Bullying  09:04 - Them or You  11:39 - Understanding Consequences  14:54 - Dehumanizing as an Excuse  17:18 - Symptoms of Being Bullied  21:10 - The Power of Support  23:40 - PTSD Similarities  31:04 - Names Can Hurt Me!  34:14 - Some Things to Help  37:00 - The Problems in Schools  41:41 - Reading, Writing & Empathy  42:50 - Wrap Up  43:17 - Next Month: Flow State and Self Compassion  43:34 - Outro   www.social-engineer.com   www.innocentlivesfoundation.org     Find us online:  Twitter: @DrAbbieofficial  LinkedIn: linkedin.com/in/dr-abbie-maroño-phd  Instagram: @DoctorAbbieofficial  Twitter: @humanhacker  LinkedIn: linkedin.com/in/christopherhadnagy      References:  Basharpoor, S., Molavi, P., Sheykhi, S., Khanjani, S., Rajabi, M., & Mosavi, S. A. (2013). The relationship between emotion regulation and emotion expression styles with bullying behaviors in adolescent Students. J Ardabil Univ Med Sci, 13(3), 264-75.  Conway, P. M., Høgh, A., Balducci, C., & Ebbesen, D. K. (2021). Workplace bullying and mental health. Pathways of job-related negative behaviour, 101-128.  deLara, E. W. (2019). Consequences of childhood bullying on mental health and relationships for young adults. Journal of Child and Family Studies, 28, 2379-2389.  Du Plessis, M. R., Smeekens, S., Cillessen, A. H., Whittle, S., & Güroǧlu, B. (2019). Bullying the brain? Longitudinal links between childhood peer victimization, cortisol, and adolescent brain structure. Frontiers in psychology, 9, 398857.  Foody, M., & Samara, M. (2018). Considering mindfulness techniques in school-based anti-bullying programmes. Journal of New Approaches in Educational Research (NAER Journal), 7(1), 3-9.  Landstedt, E., & Persson, S. (2014). Bullying, cyberbullying, and mental health in young people. Scandinavian journal of public health, 42(4), 393-399.  Mahady Wilton, M. M., Craig, W. M., & Pepler, D. J. (2000). Emotional regulation and display in classroom victims of bullying: Characteristic expressions of affect, coping styles and relevant contextual factors. Social development, 9(2), 226-245.  Moore, B., & Woodcock, S. (2017). Resilience, bullying, and mental health: Factors associated with improved outcomes. Psychology in the Schools, 54(7), 689-702.  Olweus, D. (2013). School bullying: Development and some important challenges. Annual review of clinical psychology, 9, 751-780.  Rigby, K. (2003). Consequences of bullying in schools. The Canadian journal of psychiatry, 48(9), 583-590.  Rivers, I., Poteat, V. P., Noret, N., & Ashurst, N. (2009). Observing bullying at school: The mental health implications of witness status. School Psychology Quarterly, 24(4), 211.  Rossouw, P. J. (2013). The effects of bullying on the developing brain. Strategies for effective interventions. PJ Rossouw (Ed.), 2, 102-112. 

Dave & Karl have started a civil war and they must pick a team to represent them but with multiple factors... "The longitudinal match, to end all matches! Due to an argument between Dave and Karl over the awarding of points for being late for pod recordings, the world has been split in two! Right down the middle between the two of you, following a longitudinal line down from the exact mid point between Navan and London (yes I bothered to figure out where that was). The only way to settle this argument is for the both of you to come up with a squad made of players from each of your respective hemispheres. So for Dave he gets Ireland, all of the Americas, western Spain, Portugal and a lot of west Africa, plus western Wales, most of Scotland and then Cornwall, Devon, Somerset and Dorset from England. Karl gets the rest of England, the eastern half of Spain, the rest of Europe, the bulk of Africa, then all of Asia and Australasia as well. I have included the a map so if you need a visual you can go from this! Rules are as follows. Each need to create a squad with a starting 11 and 5 subs of current players, you must have at least two players from each continent in your hemisphere, and when the match is played out, you both have to make at least three subs at 60 minutes. A little twist is you both HAVE to include one player from these nations, and they MUST be included in your mandatory 60th minute substitution. Dave - Costa Rica Karl - Finland Who might win this hypothetical game, who can put the best squad together, and who has the best hemisphere!?" Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, Dr. Valentin Fuster discusses a groundbreaking study linking urinary metal levels, particularly non-essential metals like cadmium and uranium, to coronary artery calcification, highlighting their potential role in cardiovascular disease. The findings underscore the urgent need for public health initiatives to address environmental metal exposure, as they could significantly mitigate cardiovascular risks and health disparities.

Dr. Rachel Quaney chats with Dr. Michael Keller and Dr. Burton Lee on their paper "Impact of Longitudinal Mechanical Ventilation Curriculum on Decay of Knowledge." 

Are you tired of waking up every morning, dragging yourself to the office, and counting the hours until you can clock out? If you feel your job is just a series of endless tasks without real meaning, you're not alone. Many professionals find themselves stuck in a cycle of monotony, feeling like they're just going through the motions. But work doesn't have to be this way.In this episode of the HAPPINESS SQUAD Podcast, Ashish Kothari, Founder of HAPPINESS SQUAD, shares how to uncover and activate your purpose to transform your work life into a happier and more fulfilling one.Things you will learn from this episode:• Rethinking the link between purpose and work• The importance of purpose at work• Strategies to activate purpose at work• The impact of a purpose-driven culture in an organizationFinding and activating your purpose can turn any role into a rewarding adventure. Don't settle for just a paycheck—find out how to ignite your passion at work.Tune in to this epic episode now!Resources:• Ikigai and subsequent health and wellbeing among Japanese older adults: Longitudinal outcome-wide analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814687/ • The Power of Purpose: How Ikigai Can Help Us Live Longer: https://www.forbes.com/sites/nelldebevoise/2023/10/06/the-power-of-purpose-how-ikigai-can-help-us-live-longer/ • Effect of a Purpose in Life on Risk of Incident Alzheimer's Disease and Mild Cognitive Impairment in Community-Dwelling Older Persons by Patricia Boyle: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897172/ • Jiro Dreams of Sushi (2011 movie)• Rewire Program: https://happinesssquad.com/rewire-program/ • Apple Podcast: https://podcasts.apple.com/us/podcast/the-happiness-squad/id1663683864• Website: https://happinesssquad.com/• Instagram: https://www.instagram.com/myhappinesssquad/ Books:• Hardwired for Happiness: 9 Proven Practices to Overcome Stress and Live Your Best Life.https://www.amazon.com/Hardwired-Happiness-Proven-Practices-Overcome/dp/1544534655

Dr. Kaitlyn McGraw discusses her study on the relationship between urinary trace metal levels and coronary artery calcification, highlighting the role of environmental exposures in cardiovascular disease risk. The research reveals significant associations between elevated levels of metals like cadmium, tungsten, and uranium with the progression of calcification, comparable to traditional risk factors such as smoking and diabetes. Dr. McGraw emphasizes the need for integrating environmental factors into cardiovascular risk assessments and suggests policy changes to better regulate metal exposure in the population. Moderated by Khurram Nasir, MBBS, FACC.

Shari Lipner, MD, PhD, FAAD interviewed by Sabrina Shearer, MD, FAAD

When we're growing up, it's hard to conceive that the future will feel any different than the present, but the slogan “it gets better”, made popular by sexpert Dan Savage specifically addressing LGBTQ+ youth, tries to bridge that gap with reassurance. But does it actually get better? This week, sex researcher Anna delivers a longitudinal analysis following 230 LGTBQ+ adolescents over three and a half years. The paper talks about the distress caused by harassment and the impact and correlation of social support on mental health outcomes. Turn on your mind with a listen to this dose of Carnal Knowledge, and be a beacon for kids still coming through it.Link to Study:Does It Get Better? A Longitudinal Analysis of Psychological Distress and Victimization in Lesbian, Gay, Bisexual, Transgender, and Questioning Youth Hosted on Acast. See acast.com/privacy for more information.

En una nueva edición del Rat Pack de Mesa Central, Ivan Valenzuela junto a Angélica Bulnes conversaron con el psicólogo social de la Escuela de Psicología UC e investigador del Centro de Estudios de Conflictos y Cohesión Social (COES), Roberto González, sobre el estudio “Radiografía de la Cohesión Social en Chile. Estudio Longitudinal 2016-2023”.

Devices can calm our emotional children - but does a screen actually help them to emotionally regulate or is it just distracting them from their emotions in the heat of the moment? Are there long term consequences to letting screens "manage" a child's emotions? We also talk about a controversial topic - using "screen-time" as a reward! There is an important connection between screen use and children's executive function and emotional regulation, and it's not good news! In this episode: Your words have power:  @always.upper.elementary Toothpaste Words: The most important back to school lesson you can do Should we comment on someone's appearance? Cure for tantrums? Longitudinal associations between parental digital emotion regulation and children's self-regulatory skills Using devices as digital pacifiers Frustration tolerance Unplug Childhood: Join the village, sign the petition #1038 - Managing Emotional Dysregulation Tolerable discomfort Resilience Associations between media parenting practices and early adolescent screen use  Social media Using screens as punishment or reward leads to higher screen use Alfie Kohn, author of 'Punished by Rewards' Positive/negative reinforcement The most important "app" for our children Related links:  Unplugging Parenthood #137 Punishment & Rewards with Alfie Kohn . Doors are now open to the Happy Families Membership  NEW weekly kids' ‘Print & Play' subscription FELT (Fostering Emotional Learning Together) Find us on Facebook or TikTok Subscribe to the Happy Families newsletter  See omnystudio.com/listener for privacy information.

Send us a Text Message.The longitudinal assessment of prenatal cannabis use on neonatal outcomes.Habersham LL, Hurd YL, Nomura Y.J Perinatol. 2024 Jun 18. doi: 10.1038/s41372-024-02027-w. Online ahead of print.PMID: 38890400As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Dr. Halley Alexander discusses the Neurology Today article, "Prospective Study Presents Longitudinal Trajectory of Cognitive Impairment in Patients With Essential Tremor" by Susan Kreimer, available in the June 20th issue of Neurology Today or at neurologytoday.com.  Show reference:  https://journals.lww.com/neurotodayonline/fulltext/2024/06200/prospective_study_presents_longitudinal_trajectory.2.aspx This podcast is sponsored by argenx. Visit www.vyvgarthcp.com for more information.

Read this carefully: children of fathers with mild depressive symptoms or anxiety tend to have fewer behavioral difficulties and higher IQs. Yup. We'll talk a bit about the research here, but we want to emphasize the huge benefits of acknowledging and sharing mental health struggles with those close to us. Yes, that means emotional openness is a parenting strength. That means parents and adults can model how to navigate tough emotions in such a way that builds personal growth and enhanced resilience in both themselves and the kids around them. This episode goes out to all the dads, but it's really true for all of us. Joy Lab and Natural Mental Health are community-supported. When you buy through the links below, we may earn a commission. That support helps keep the Joy Lab podcast free for all!   Sources and Notes: Joy Lab Program: Take the next leap in your wellbeing journey with step-by-step practices to help you build and maintain the elements of joy in your life. Your Joy Lab membership also includes our NMH Community! NMH Community: Access lots of extra resilience-boosting resources AND join a group of inspiring folks who play an integral role in keeping this podcast going. Where to shop: Our partner store, Fullscript: Here you can find high-quality supplements and wellness products. Except for our CBD Gummies, any product links mentioned in the show notes will require an account. Sign up for free. Resilient Remedies: Shop our line of trusted, high-quality CBD gummies. Subscribe to our Newsletter: Join us over at NaturalMentalHealth.com for exclusive emails, updates, and additional strategies. Check out our favorite resilience-boosting reads at Bookshop.org.  Study referenced: Longitudinal associations between paternal mental health and child behavior and cognition in middle childhood Full transcript here Please remember that this content is for informational and educational purposes only. It is not intended to provide medical advice and is not a replacement for advice and treatment from a medical professional. Please consult your doctor or other qualified health professional before beginning any diet change, supplement, or lifestyle program. Please see our terms for more information. If you or someone you know is struggling or in crisis, help is available. Call the NAMI HelpLine: 1-800-950-6264 available Monday through Friday, 10 a.m. – 10 p.m., ET. OR text "HelpLine" to 62640 or email NAMI at helpline@nami.org. Visit NAMI for more. You can also call or text SAMHSA at 988 or chat 988lifeline.org.

Once Dr. Ray Damadian had the idea to create a machine that used nuclear magnetic resonance to capture diagnostic data by scanning a human body, he still had to build it. And though he did, other scientists got credit for inventing the MRI.   Research: Bashir U, Rock P, Murphy A, et al. T2 relaxation. Reference article, Radiopaedia.org. https://doi.org/10.53347/rID-16494 Bellis, Mary. "A Guide to Magnetic Resonance Imaging (MRI)." ThoughtCo, Apr. 5, 2023, thoughtco.com/magnetic-resonance-imaging-mri-1992133 Bloch, Felix. “The Principle of Nuclear Induction.” Nobel Lecture. Dec. 11, 1952. https://www.nobelprize.org/uploads/2018/06/bloch-lecture-1.pdf Bloembergen, Nicolas. “Edward M. Purcell (1912-97).” Nature. April 17, 1997. https://www.nature.com/articles/386662a0.pdf Britannica, The Editors of Encyclopaedia. "Isidor Isaac Rabi". Encyclopedia Britannica, 3 Apr. 2024, https://www.britannica.com/biography/Isidor-Isaac-Rabi Britannica, The Editors of Encyclopaedia. "Paul Lauterbur". Encyclopedia Britannica, 2 May. 2024, https://www.britannica.com/biography/Paul-Lauterbur Britannica, The Editors of Encyclopaedia. "nuclear magnetic resonance". Encyclopedia Britannica, 25 Apr. 2024, https://www.britannica.com/science/nuclear-magnetic-resonance Damadian, Raymond, and Jeff Kinley. “Gifted Mind: The Dr. Raymond Damadian Story.” Master Books. 2015. Damadian R. “Tumor detection by nuclear magnetic resonance.” Science. 1971 Mar 19;171(3976):1151-3. doi: 10.1126/science.171.3976.1151 Deutsch, Claudia H. “Patent Fights Aplenty for MRI Pioneer.” New York Times. July 12, 1997. https://www.nytimes.com/1997/07/12/business/patent-fights-aplenty-for-mri-pioneer.html “Dr. Edward Purcell, 84, Dies; Shared Nobel Prize in Physics.” New York Times. March 10, 1997. https://www.nytimes.com/1997/03/10/us/dr-edward-purcell-84-dies-shared-nobel-prize-in-physics.html Drew Z, Jones J, Murphy A, et al. Longitudinal and transverse magnetization. Reference article, Radiopaedia.org (Accessed on 03 Jun 2024) https://doi.org/10.53347/rID-60738 "Edward Mills Purcell." National Academy of Sciences. 2000. Biographical Memoirs: Volume 78. Washington, DC: The National Academies Press. doi: 10.17226/9977 :"Felix Bloch." National Academy of Sciences. 1994. Biographical Memoirs: Volume 64. Washington, DC: The National Academies Press. doi: 10.17226/4547 LAUTERBUR, P. Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance. Nature242, 190–191 (1973). https://doi.org/10.1038/242190a0 National Academies of Sciences, Engineering, and Medicine. 1994. Biographical Memoirs: Volume 64. Washington, DC: The National Academies Press. https://doi.org/10.17226/4547. National Academies of Sciences, Engineering, and Medicine. 2000. Biographical Memoirs: Volume 78. Washington, DC: The National Academies Press. https://doi.org/10.17226/9977. Hofstadter, Robert. “Felix Bloch.” National Academies of Sciences, Engineering, and Medicine. 1994. Biographical Memoirs: Volume 64. Washington, DC: The National Academies Press. https://doi.org/10.17226/4547. Isidor Isaac Rabi – Biographical. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 4 Jun 2024. https://www.nobelprize.org/prizes/physics/1944/rabi/biographical/ Jones J, Howden W, Rock P, et al. T1 relaxation time. Reference article, Radiopaedia.org (Accessed on 03 Jun 2024) https://doi.org/10.53347/rID-6315 Luiten, A.L. (1999). Magnetic Resonance Imaging: A Historical Introduction. In: Magnetic Resonance Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03800-0_1 MacWilliams, B. Russian claims first in magnetic imaging. Nature426, 375 (2003). https://doi.org/10.1038/426375a “Magnetic Resonance Imaging (MRI).” National Institute of Biomedical Imaging and BioEngineering. https://www.nibib.nih.gov/science-education/science-topics/magnetic-resonance-imaging-mri “The Man Who Did Not Win.” Sydney Morning Herald. October 17, 2003. https://www.smh.com.au/national/the-man-who-did-not-win-20031017-gdhlpn.html Odeblad E, Lindström G. Some preliminary observations on the proton magnetic resonance in biologic samples. Acta Radiol Suppl (Stockholm). 2008 Aug;434:57-61. doi: 10.1080/02841850802133337 Paul C. Lauterbur – Biographical. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 4 Jun 2024. https://www.nobelprize.org/prizes/medicine/2003/lauterbur/biographical/ Plewes, Donald B., PhD, and Walter Kucharczyk, PhD. “Physics of MRI: A Primer.” MR Physics for Clinicians. April 12, 2012. https://doi.org/10.1002/jmri.23642 Prasad, Amit. “The (Amorphous) Anatomy of an Invention: The Case of Magnetic Resonance Imaging (MRI).” Social Studies of Science, vol. 37, no. 4, 2007, pp. 533–60. JSTOR, http://www.jstor.org/stable/25474534 Purcell, E.M. et al. “Resonance Absorption by Nuclear Magnetic Moments in a Solid.” Physics Review. January 1, 1946. https://journals.aps.org/pr/pdf/10.1103/PhysRev.69.37 “Raymond Damadian.” Lemelson-MIT. https://lemelson.mit.edu/award-winners/raymond-damadian Sandomir, Richard. “Raymond Damadian, Creator of the First M.R.I. Scanner, Dies at 86.” New York Times. Aug. 17, 2022. https://www.nytimes.com/2022/08/17/science/raymond-damadian-dead.html Serai, Suraj, PhD, and Tony Dandino. “Why are MRI scans so loud?” Cincinnati Children's Radiology Department Blog. October 13, 2016. https://radiologyblog.cincinnatichildrens.org/whats-with-all-the-noise/ Sullivan, Walter. “Five Named as Winners of Lasker Medical Research Awards.” New York Times. Nov. 15, 1984. https://www.nytimes.com/1984/11/15/us/five-named-as-winners-of-lasker-medical-research-awards.html National Academies of Sciences, Engineering, and Medicine. 2000. Biographical Memoirs: Volume 78. Washington, DC: The National Academies Press. https://doi.org/10.17226/9977. Wakefield, Julie. “The ‘Indomitable' MRI.” Smithsonian. June 2000. https://www.smithsonianmag.com/science-nature/the-indomitable-mri-29126670/ See omnystudio.com/listener for privacy information.

Who invented the MRI? Well, that's actually tricky to say, and it is a topic that still opens debate. In this first part, we'll talk about the various developments in physics that led to the idea of an MRI machine even existing. Research: Bashir U, Rock P, Murphy A, et al. T2 relaxation. Reference article, Radiopaedia.org. https://doi.org/10.53347/rID-16494 Bellis, Mary. "A Guide to Magnetic Resonance Imaging (MRI)." ThoughtCo, Apr. 5, 2023, thoughtco.com/magnetic-resonance-imaging-mri-1992133 Bloch, Felix. “The Principle of Nuclear Induction.” Nobel Lecture. Dec. 11, 1952. https://www.nobelprize.org/uploads/2018/06/bloch-lecture-1.pdf Bloembergen, Nicolas. “Edward M. Purcell (1912-97).” Nature. April 17, 1997. https://www.nature.com/articles/386662a0.pdf Britannica, The Editors of Encyclopaedia. "Isidor Isaac Rabi". Encyclopedia Britannica, 3 Apr. 2024, https://www.britannica.com/biography/Isidor-Isaac-Rabi Britannica, The Editors of Encyclopaedia. "Paul Lauterbur". Encyclopedia Britannica, 2 May. 2024, https://www.britannica.com/biography/Paul-Lauterbur Britannica, The Editors of Encyclopaedia. "nuclear magnetic resonance". Encyclopedia Britannica, 25 Apr. 2024, https://www.britannica.com/science/nuclear-magnetic-resonance Damadian, Raymond, and Jeff Kinley. “Gifted Mind: The Dr. Raymond Damadian Story.” Master Books. 2015. Damadian R. “Tumor detection by nuclear magnetic resonance.” Science. 1971 Mar 19;171(3976):1151-3. doi: 10.1126/science.171.3976.1151 Deutsch, Claudia H. “Patent Fights Aplenty for MRI Pioneer.” New York Times. July 12, 1997. https://www.nytimes.com/1997/07/12/business/patent-fights-aplenty-for-mri-pioneer.html “Dr. Edward Purcell, 84, Dies; Shared Nobel Prize in Physics.” New York Times. March 10, 1997. https://www.nytimes.com/1997/03/10/us/dr-edward-purcell-84-dies-shared-nobel-prize-in-physics.html Drew Z, Jones J, Murphy A, et al. Longitudinal and transverse magnetization. Reference article, Radiopaedia.org (Accessed on 03 Jun 2024) https://doi.org/10.53347/rID-60738 "Edward Mills Purcell." National Academy of Sciences. 2000. Biographical Memoirs: Volume 78. Washington, DC: The National Academies Press. doi: 10.17226/9977 :"Felix Bloch." National Academy of Sciences. 1994. Biographical Memoirs: Volume 64. Washington, DC: The National Academies Press. doi: 10.17226/4547 LAUTERBUR, P. Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance. Nature242, 190–191 (1973). https://doi.org/10.1038/242190a0 National Academies of Sciences, Engineering, and Medicine. 1994. Biographical Memoirs: Volume 64. Washington, DC: The National Academies Press. https://doi.org/10.17226/4547. National Academies of Sciences, Engineering, and Medicine. 2000. Biographical Memoirs: Volume 78. Washington, DC: The National Academies Press. https://doi.org/10.17226/9977. Hofstadter, Robert. “Felix Bloch.” National Academies of Sciences, Engineering, and Medicine. 1994. Biographical Memoirs: Volume 64. Washington, DC: The National Academies Press. https://doi.org/10.17226/4547. Isidor Isaac Rabi – Biographical. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 4 Jun 2024. https://www.nobelprize.org/prizes/physics/1944/rabi/biographical/ Jones J, Howden W, Rock P, et al. T1 relaxation time. Reference article, Radiopaedia.org (Accessed on 03 Jun 2024) https://doi.org/10.53347/rID-6315 Luiten, A.L. (1999). Magnetic Resonance Imaging: A Historical Introduction. In: Magnetic Resonance Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03800-0_1 MacWilliams, B. Russian claims first in magnetic imaging. Nature426, 375 (2003). https://doi.org/10.1038/426375a “Magnetic Resonance Imaging (MRI).” National Institute of Biomedical Imaging and BioEngineering. https://www.nibib.nih.gov/science-education/science-topics/magnetic-resonance-imaging-mri “The Man Who Did Not Win.” Sydney Morning Herald. October 17, 2003. https://www.smh.com.au/national/the-man-who-did-not-win-20031017-gdhlpn.html Odeblad E, Lindström G. Some preliminary observations on the proton magnetic resonance in biologic samples. Acta Radiol Suppl (Stockholm). 2008 Aug;434:57-61. doi: 10.1080/02841850802133337 Paul C. Lauterbur – Biographical. NobelPrize.org. Nobel Prize Outreach AB 2024. Tue. 4 Jun 2024. https://www.nobelprize.org/prizes/medicine/2003/lauterbur/biographical/ Plewes, Donald B., PhD, and Walter Kucharczyk, PhD. “Physics of MRI: A Primer.” MR Physics for Clinicians. April 12, 2012. https://doi.org/10.1002/jmri.23642 Prasad, Amit. “The (Amorphous) Anatomy of an Invention: The Case of Magnetic Resonance Imaging (MRI).” Social Studies of Science, vol. 37, no. 4, 2007, pp. 533–60. JSTOR, http://www.jstor.org/stable/25474534 Purcell, E.M. et al. “Resonance Absorption by Nuclear Magnetic Moments in a Solid.” Physics Review. January 1, 1946. https://journals.aps.org/pr/pdf/10.1103/PhysRev.69.37 “Raymond Damadian.” Lemelson-MIT. https://lemelson.mit.edu/award-winners/raymond-damadian Sandomir, Richard. “Raymond Damadian, Creator of the First M.R.I. Scanner, Dies at 86.” New York Times. Aug. 17, 2022. https://www.nytimes.com/2022/08/17/science/raymond-damadian-dead.html Serai, Suraj, PhD, and Tony Dandino. “Why are MRI scans so loud?” Cincinnati Children's Radiology Department Blog. October 13, 2016. https://radiologyblog.cincinnatichildrens.org/whats-with-all-the-noise/ Sullivan, Walter. “Five Named as Winners of Lasker Medical Research Awards.” New York Times. Nov. 15, 1984. https://www.nytimes.com/1984/11/15/us/five-named-as-winners-of-lasker-medical-research-awards.html National Academies of Sciences, Engineering, and Medicine. 2000. Biographical Memoirs: Volume 78. Washington, DC: The National Academies Press. https://doi.org/10.17226/9977. Wakefield, Julie. “The ‘Indomitable' MRI.” Smithsonian. June 2000. https://www.smithsonianmag.com/science-nature/the-indomitable-mri-29126670/ See omnystudio.com/listener for privacy information.

**Alert! The name of this podcast is changing on June 4th to Open Heart Surgery with Boots! Be sure to subscribe so you don't miss the announcement. Be sure to subscribe to the newsletter!**Boots brings you heart news that caught her eye for the month of April in a new monthly segment! Let Boots know what you want to hear more of or less of by sending her an email boots@theheartchamberpodcast.comRisk of heart disease rises sharply in women after menopause, study - Times of India (indiatimes.com)Artificial intelligence shows that social isolation impacts cardiovascular age and mortality rate - Mayo Clinic4-year-old who received new heart after waiting 1,025 days goes home from hospital - ABC NewsResearch uncovers hidden link between heart attacks and cancer - ISRAEL21cBlake Hospital performs first minimally invasive mitral valve repair (mysuncoast.com)Longitudinal blood glucose level and increased silent myocardial infarction: a pooled analysis of four cohort studies | Cardiovascular Diabetology | Full Text (biomedcentral.com)Boots Knighton has been an educator since the late 1990s in all facets of education including high school science, middle school mathematics, elementary reading, college level ecology, ski instruction, backpacking, and experiential education. Her greatest teacher has been her heart thanks to a surprise diagnosis in 2020 (during the pandemic) of three different congenital heart defects. She is now thriving after her open-heart surgery on January 15, 2021 and is on a mission to raise awareness through her podcast, The Heart Chamber: patient stories of open-heart surgery and recovery, that heart surgery can be an incredible opportunity to begin again in life and live life wide open. **I am not a doctor and this is not medical advice. Be sure to check in with your care team about all the next right steps for you and your heart.**How to connect with BootsEmail: Boots@theheartchamberpodcast.comInstagram: @openheartsurgerywithboots or @boots.knightonLinkedIn: linkedin.com/in/boots-knightonBoots...

Featuring perspectives from Dr Naveen Pemmaraju, including the following topics: Recent developments in management approaches for myelofibrosis prior to ASH 2023 (0:00) Updated data with navitoclax in combination with ruxolitinib for patients with myelofibrosis (12:35) Key findings with pelabresib in combination with ruxolitinib for JAK inhibitor treatment-naïve myelofibrosis in the Phase III MANIFEST-2 study (22:21) Long-term follow-up from the Phase I/III XPORT-MF-034 trial of selinexor with ruxolitinib for JAK inhibitor-naïve myelofibrosis (29:10) Effect of new or worsening anemia on clinical outcomes in patients with myelofibrosis treated with ruxolitinib in the expanded-access JUMP study (34:33) Results from the Phase III FREEDOM-2 study of fedratinib for patients with myelofibrosis after prior ruxolitinib (40:38) Landmark survival analysis of the Phase III PERSIST-2 trial evaluating pacritinib versus best available therapy in patients with myelofibrosis and thrombocytopenia (43:08) Retrospective analysis of the PAC203 and PERSIST-2 studies of pacritinib for cytopenic myelofibrosis (47:56) Longitudinal assessment of transfusion intensity in patients who received momelotinib for myelofibrosis in the Phase III SIMPLIFY-1 and MOMENTUM trials (52:48) Two-year follow-up from the Phase II REVIVE study of rusfertide in phlebotomy-dependent patients with polycythemia vera (55:18) Available Phase I/II data with the novel agent zilurgisertib with or without ruxolitinib in patients with anemia due to myelofibrosis (58:56) CME information and select publications

Is it possible to breed a species of bee with total viral immunity? Maybe, and the research being done in Michelle Flenniken's lab could pave the way for it to happen. Tune in to discover: Whether bees might utilize a form of preventative medicine In what way a honeybee model for insect immunity might be superior to the status quo fruit fly model Why the term “honeybee viruses” might be misleading Michelle Flenniken is Assistant Professor in the Plant Sciences Department and Co-Director of the Pollinator Health Center at Montana State University whose primary research is focused not only on understanding the impact of viruses on honeybees, but on the molecular mechanisms that bees have evolved to combat viral infections. Longitudinal monitoring projects looking at the prevalence and abundance of 16 pathogens across several bee colonies over time have led to interesting and useful findings. For instance, Flenniken's lab has shown that bees that are infected with viruses have perturbation in the genes that are important for metabolic processes, and that even in so-called asymptomatic bees, there are more than a billion copies of RNA viruses per bee. The hypothesis that follows this finding is that this viral load could be energetically taxing on bees—even if the bees appear phenotypically normal. More recent research in Flenniken's lab has shown that a bee's immune response is stimulated by double-stranded RNA, which is a molecule that viruses produce when replicating; this molecule stimulates RNA interference in bees—an antiviral mechanism. This has shown to be true also in bumblebees, but is not the case in the fruit fly, which is the go-to model for studying insect immunity. This has opened the door to more exciting and new research that Flenniken and her lab are gearing up to conduct. If antiviral mechanisms in bees can be fully understood, then it may be possible to identify the genes associated with fighting off viral infection, which would make it possible to breed honeybees that are resistant or immune to viral infections. Flenniken discusses the details of all this and more, including viral transmission in bees and across species, whether different castes of bees are differentially impacted by viruses, host-pathogen interaction studies, and which viruses most commonly impact bees. Check out https://plantsciences.montana.edu/directory/faculty/1524085/michelle-flenniken to learn more. Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Available on Apple Podcasts: apple.co/2Os0myK

Today, Dr. Vincent Young of the University of Michigan Department of Internal Medicine and Infectious Disease Division in Ann Arbor, joins the #QualityQuorum to chat about the ecology of the human gut as it relates to a serious bacterial disease caused by Clostridiodes difficile.  He will also discuss what it is like to be a medical scientist with both MD and PhD degrees. Host: Mark O. Martin Guest: Vincent Young Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode Backyard DNA sequencing—is this a possibility?  Here is a source of information.  And Sebastian Cocioba is a great source of information. The company Giant Microbes makes a  C. diff plush toy. An introduction to C. difficile the bacterium. An introduction to the disease caused by C. difficile. Some journal articles by Dr. Young and his colleagues and discussed in this podcast:  “Viewing Bacterial Colonization through the Lens of Systems Biology,” “Capturing the environment of the Clostridioides difficile infection cycle,” “Microbiome therapeutics for the treatment of recurrent Clostridioides difficile infection,” and “Longitudinal genomic surveillance ofcarriage and transmission of Clostridioides difficile in an intensive care unit.” Dr. Young's colleague Dr. Madeline Barron, who writes wonderful essays about microbiology for the American Society for Microbiology. An informative interview with Dr. Young.  Here is another good interview.  A good biography of Dr. Young from ASM. Dr. Young's faculty website. Dr. Young's laboratory website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent's comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles tracking (CDC) What happens when measles is included in commercial syndromic PCR panels (MMWR) Influenza/flu surveillance (CDC) Influenza on the Texas ranch (Statnews) Sequence analysis of highly pathogenic avian influenza from Texas (CDC) Influenza/flu map (CDC) COVID-19  hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Can inflammatory cytokines and antibodies play nicely to prevent COVID-19 mortality (IJID) Association of GLP-1RA and SGLT-2i to modulate COVID-19 severity (Diabetes Therapy) Spring COVID-19 booster recommendations (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Remdesivir and cardiac adverse events in hospitalized patients (CID) Long COVID evidence based review TWiV shout out (TWiV 1088) Longitudinal study reveals long COVID symptom peaks and nadirs (OFID) Paxlovid lowers risk of cardiovascular disease in COVID-19 patients with autoimmune disease (BMC Medicine) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1102 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

CHEST April 2024, Volume 165, Issue 4 Sonia Graziano, PsyD, joins CHEST Podcast Moderator Gretchen Winter, MD, to discuss how elexacaftor/tezacaftor/ivacaftor affects mental health, cognitive processing, neuropsychological side effects, GI symptoms, and health-related quality of life in people with cystic fibrosis. DOI: https://doi.org/10.1016/j.chest.2023.10.043   Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.

In this episode: Linda reviews an article chosen by Medical Education. She calls it “When is a clerkship not a clerkship?” Length: 20:05 min Authors: Worley P, Couper I, Strasser R, Graves L, Cummings B-A, Woodman R, Stagg S, Hirsh D and the Consortium of Longitudinal Integrated Clerkships (CLIC). Publication details: A typology of longitudinal integrated clerkships. Medical Education. 2016. [epub ahead of print] PubMed Link 

Many people believe the pursuit of good health and healing has been derailed by modern medical thinking that focuses on one narrow way of doing things — often not the best way — while disregarding everything else, including vital and proven spiritual knowledge.Dr. Robert Gilbert makes his long overdue return to the podcast to help us better understand the connections between ancient spiritual knowledge and modern discoveries like BioGeometry and Cymatics in this healing Living 4D conversation. Learn more about Robert's work with sacred geometry at vesica.org. For Living 4D listeners: Save $75 off two of the Vesica Institute's most popular courses — Essential Teachings and Practices of Spiritual Science and The Personal Wavelength (good for one year of unlimited access) — by using the promo code PAUL75 at checkout.  TimestampsHow ancient spiritual knowledge connects with and gives a larger context to modern scientific discoveries in ways that help us understand and apply it. (8:31)The causal plane. (14:07)Scalar energy. (23:45)BioGeometry: The equilibrium point for all types of biological systems. (30:37)A definition of dimension from Robert's perspective. (37:38)The LD50/median lethal dose. (45:04)“Deep thinking burns up life energy in the body.” (56:23)Longitudinal and transverse waves. (1:09:01)Cymatics explains how invisible energy wave structure matters. (1:14:44)How the supplementary motor area of your brain intersects with the Chakra system. (1:22:40)What promotes better healing through electromagnetics: A TENS unit or microcurrent therapy? (1:27:45)The subtle energy problems with owning and using second-hand items. (1:35:56)Do you blame others for their illnesses and physical challenges? (1:47:00)Sacred geometry of space and time that operates on the astral and physical planes. (1:56:32)Memento mori: Remember that you will die. (2:02:42)Past life regression and embedded trauma. (2:11:53)Expanding our unconscious is the foundation of mindfulness. (2:20:39)How to instill more consciousness in ourselves every time we incarnate. (2:32:37)ResourcesWatchmen by Alan Moore and Dave GibbonsHealing is Voltage: The Handbook by Jerry TennantFind more resources for this episode on our website.Thanks to our awesome sponsors:PaleovalleyBiOptimizers US and BiOptimizers UK PAUL10Organifi CHEK20CHEK Institute/How to Eat, Move and Be Healthy Online programWild PasturesWe may earn commissions from qualifying purchases using affiliate links.

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ossification Posterior Longitudinal Ligament ⁠⁠ ⁠⁠⁠⁠from the Spine section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Orthobullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Social Media: ⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠YouTube --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message