Podcasts about Longitudinal

Welcome to the latest Midlife Minute. Today, I'm taking a closer look at oral contraceptive use in perimenopause and menopause, exploring how oral contraceptives work, how they suppress or blunt perimenopausal and menopausal symptoms, alter hormone signaling and testing, what women may experience when they stop taking them, and why the gut microbiome is an essential part of the conversation. IN THIS EPISODE, YOU WILL LEARN: How oral contraceptives suppress certain key signaling hormones, making it difficult to assess women's menopausal status accurately What women may experience when transitioning off oral contraceptives How long-term oral contraceptive use can alter gut microbial function and inflammatory pathways The association between long-term oral contraceptive use and nutrient depletion Why the standard reproductive hormone markers used to assess menopause (especially FSH/LH) are unreliable while on the pill How the microbiome changes that occur as women age may compound the effects of previous oral contraceptive use Helpful dietary, microbiome, and lifestyle strategies to support women navigating the post-pill transition Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Resources:  Sitruk-Ware R, Nath A. Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills. Best Practice and Research: Clinical Endocrinology and Metabolism. 2013;27(1):13–24. doi:10.1016/j.beem.2012.09.004 Schaffir J, Worly BL, Gur TL. Combined hormonal contraception and its effects on mood: a critical review. European Journal of Contraception and Reproductive Health Care. 2016;21(5):347–355. doi:10.1080/13625187.2016.1217327 Panzer C, Wise S, Fantini G, Kang D, Munarriz R, Guay A, Goldstein I. Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: a retrospective study in women with sexual dysfunction. Journal of Sexual Medicine. 2006;3(1):104–113. doi:10.1111/j.1743-6109.2005.00198.x Palmery M, Saraceno A, Vaiarelli A, Carlomagno G. Oral contraceptives and changes in nutritional requirements. European Review for Medical and Pharmacological Sciences. 2013;17(13):1804–1813. PMID:23852908 Khalili H, Higuchi LM, Ananthakrishnan AN, Richter JM, Feskanich D, Fuchs CS, Chan AT. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut. 2013;62(8):1153–1159. doi:10.1136/gutjnl-2012-302362 Flores R, Shi J, Fuhrman B, Xu X, Veenstra TD, Gail MH, Gajer P, Ravel J, Goedert JJ. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. Journal of Translational Medicine. 2012;10:253. doi:10.1186/1479-5876-10-253 Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: physiological and clinical implications. Maturitas. 2017;103:45–53. doi:10.1016/j.maturitas.2017.06.025 Hua X, Cao Y, Morgan DM, Miller K, Chin SM, Bellavance D, Khalili H. Longitudinal analysis of the impact of oral contraceptive use on the gut microbiome. Journal of Medical Microbiology. 2022;71(4):001512. doi:10.1099/jmm.0.001512 Mihajlovic J, Leutner M, Hausmann B, Kohl G, Schwarz J, et al. Combined hormonal contraceptives are associated with minor changes in composition and diversity in gut microbiota of healthy women. Environmental Microbiology. 2021;23(6):3037–3047. doi:10.1111/1462-2920.15461 Seelig MS. Increased magnesium need with use of combined oestrogen and calcium supplementation. Magnesium Research. 1990;3(3):197–215. PMID:2133742 Donders GGG, Bellen G, Mendling W. Management of recurrent vulvo-vaginal candidosis as a chronic illness. Gynecologic and Obstetric Investigation. 2010;70(4):306–321. doi:10.1159/000314022 Krog MC, Hugerth LW, Fransson E, et al. The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle. Human Reproduction. 2022;37(7):1525–1543. doi:10.1093/humrep/deac094

Colin Lawlor, CEO of Sleep ai, is focused on exploring sleep intelligence and sleep as a vital sign of health. The Sleep ai platform measures sleep longitudinally using data from consumer wearables and smartphones, with an emphasis on night-to-night variability, which is not captured in a single-night sleep lab. Poor sleep and variation in sleep patterns have been identified as highly predictive indicators of over 130 chronic diseases and have an impact on mental well-being and the effectiveness of medical treatments. Colin explains, "What we're doing is we're measuring sleep longitudinally, over the long term, and we're measuring it from whatever device the consumer has. For some consumers or patients, it may be wearable, and there are many, many different wearables, or for others, it's simply from their phone. We have the ability to collect high-quality sleep data from everyone every day. And that's really important because when we get into this, we'll talk about why longitudinal measurement is really helpful in dealing with sleep challenges themselves, but also in seeing sleep as a window into literally everything to do with our health."   "There are several factors going on here. The first one is that globally, four billion people wake up tired almost every day. We do not have, and we will never have, a sufficient number of sleep labs to send all of them for a one-night study. And if we collect data for only one night, we're only getting one picture of how that person is sleeping. But as we all know, life gets in the way. We may have had a stressful day, or we may have had an argument with our significant other. We may be suffering from a cold."   "Whatever it is, all of these multiple factors influence sleep. So if we over-rely on one data point to understand what's going on, it's just not sufficient. So what we are finding is that, actually, the variance night to night is probably the most useful and insightful thing we can see. Because when we look at the variance across many nights, we have a much more accurate picture of what's happening with the person's sleep, and that's highly predictive of many, many other conditions, issues, and challenges."  #SleepAI #DigitalHealth #SleepAsAVitalSign #ChronicDisease #PopulationHealth #AIinHealthcare #Wearables #LongitudinalData #SleepHealth, #SleepScience  sleep.ai Download the transcript here

Colin Lawlor, CEO of Sleep ai, is focused on exploring sleep intelligence and sleep as a vital sign of health. The Sleep ai platform measures sleep longitudinally using data from consumer wearables and smartphones, with an emphasis on night-to-night variability, which is not captured in a single-night sleep lab. Poor sleep and variation in sleep patterns have been identified as highly predictive indicators of over 130 chronic diseases and have an impact on mental well-being and the effectiveness of medical treatments. Colin explains, "What we're doing is we're measuring sleep longitudinally, over the long term, and we're measuring it from whatever device the consumer has. For some consumers or patients, it may be wearable, and there are many, many different wearables, or for others, it's simply from their phone. We have the ability to collect high-quality sleep data from everyone every day. And that's really important because when we get into this, we'll talk about why longitudinal measurement is really helpful in dealing with sleep challenges themselves, but also in seeing sleep as a window into literally everything to do with our health."   "There are several factors going on here. The first one is that globally, four billion people wake up tired almost every day. We do not have, and we will never have, a sufficient number of sleep labs to send all of them for a one-night study. And if we collect data for only one night, we're only getting one picture of how that person is sleeping. But as we all know, life gets in the way. We may have had a stressful day, or we may have had an argument with our significant other. We may be suffering from a cold."   "Whatever it is, all of these multiple factors influence sleep. So if we over-rely on one data point to understand what's going on, it's just not sufficient. So what we are finding is that, actually, the variance night to night is probably the most useful and insightful thing we can see. Because when we look at the variance across many nights, we have a much more accurate picture of what's happening with the person's sleep, and that's highly predictive of many, many other conditions, issues, and challenges."  #SleepAI #DigitalHealth #SleepAsAVitalSign #ChronicDisease #PopulationHealth #AIinHealthcare #Wearables #LongitudinalData #SleepHealth, #SleepScience  sleep.ai Listen to the podcast here

A guide to diagnosing, imaging, and managing acute renal colic and nephrolithiasis in the ED. Hosts: Brian Gilberti, MD Avir Mitra, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/Nephrolithiasis.mp3 Download Leave a Comment Tags: Kidney Stones, Urology Show Notes 1. CLINICAL CORE & PHYSIOLOGIC FRAMEWORK Epidemiologic Risk Profiles Lifetime incidence parameters hover around 1 in 11, presenting with a prominent male sex skew. Peak demographic manifestation concentrated within the 30–60 age band. High-yield temporal parameter: 50% recurrence vector within a 5-year post-initial-insult window. Mineralogical Composition Vectors Calcium oxalate crystals represent the predominant structural matrix. Struvite configurations (magnesium ammonium phosphate matrix) account for 1–2% of cohorts. Struvite stones function explicitly as infection-driven configurations secondary to upper tract proliferation; higher distribution index noted in female cohorts. Etiological & Modifiable Relational Dynamics Profound systemic dehydration or low baseline fluid throughput states. High-sodium diet structures and heavy animal-protein consumption loads. Positive genetic/familial history variables. Relative risk modulation: Each variable independently operates to expand baseline risk by a factor of 2x to 3x. Pathophysiologic Symptom Complexes Acute, sudden-onset, maximum-intensity (10/10) unilateral flank pain. Classic structural radiation vector tracking downward toward the ipsilateral groin/genitourinary dermatomes. Distinctive behavioral marker: Renal colic pacing/writhing behavior with zero antalgic position availability. Concomitant autonomic triggers: Nausea and emesis manifest in 50% of acute presentations. Physical Exam Discordance Metrics Severe subjective distress contrasted with a characteristically soft, completely non-tender abdominal palpation exam. CVA tenderness is completely variable and lacks reliable negative predictive value. Atypical Presentation Classifications Vague, poorly localized abdominal pain presentations occurring in up to 20% of active cases. Isolated lower urinary tract irritative signs including acute frequency or severe urgency. Incidental & Asymptomatic Dynamics Silent intrarenal or ureteral stones found incidentally. Longitudinal tracking demonstrates up to 33.3% of initially asymptomatic cohorts convert to fully symptomatic renal colic within a multi-year tracking window. 2. EXCLUSION DIAGNOSES & CRITICAL PATHWAY RED FLAGS Vascular Mimics: AAA rupture/expansion. This is a mandatory exclusion pathway in elderly cohorts presenting with acute flank or back pain. Physical tracking requires active exploration for an expansile, pulsatile abdominal mass. Gynecologic Emergencies: Ruptured ectopic pregnancy. Demands universal screening protocols via rapid beta-hCG testing in all female patients of childbearing potential presenting with lower abdominal/pelvic localization. Infectious Upper Tract Decompensation: Acute uncomplicated pyelonephritis. Differentiated via persistent high spikes, high fevers, systemic shaking chills, and profound pyuria. Genitourinary Structural Crises: Acute testicular torsion. Mandates a thorough, explicit scrotal/testicular structural exam if the flank pain radiates into the scrotum. Gastrointestinal and Adnexal Torsional Confounds: Acute appendicitis variants, acute mesenteric/bowel ischemia, and ovarian torsion syndromes. 3. LABORATORY TESTING & PHYSIOLOGIC EVALUATION Urinalysis Interpretation Nuances Microscopic or gross hematuria presents in approximately 66% to 90% of acute cases. Critical Pathological Caveat: Complete absence of hematuria documented in 20% to 33.3% of confirmed, acute obstructing ureteral stones. Diagnostic rule: A pristine urinalysis with zero red blood cells is entirely insufficient to exclude acute ureterolithiasis. Urinary pH as a Composition Clue Consistently low urinary pH parameters (pH < 5.5) point strongly toward a uric acid crystalline composition. Elevated urinary pH parameters (pH > 7.5) indicate the presence of urease-producing microbial pathogens, pointing toward a struvite infection stone. Infectious Screening Metrics Active tracking for marked pyuria, positive leukocyte esterase, and bacterial nitrites to rule out an obstructed, infected upper urinary tract system. BMP Immediate quantification of baseline serum creatinine to establish accurate eGFR values. Targeting detection of post-renal AKI from bilateral obstruction, unilateral obstruction in a single functioning kidney, or severe volume depletion. CBC Evaluation for marked leukocytosis. Physiologic Nuance: Mild-to-moderate white blood cell count elevations frequently represent non-specific stress demargination driven by severe pain and repetitive vomiting. High-grade white blood cell shifts demand immediate exclusion of systemic bacteremia or an infected, obstructed urinary system. Adjunctive Lab Pathways Rapid qualitative urine hCG testing. Reflex urine culture execution whenever urinalysis metrics display significant inflammatory profiles or clinical suspicion of UTI is high. 4. IMAGING MODALITIES & ALGORITHMIC CLINICAL SELECTION Non-Contrast CT Diagnostics Gold standard; diagnostic sensitivity and specificity parameters exceed 95% for stones >2 mm. Provides precise quantification of stone diameter (mm), exact localization (proximal, mid, or distal ureter), and degree of secondary hydronephrosis. Excellent structural visualization for detecting or ruling out alternate retroperitoneal, vascular, or intra-abdominal pathologies. Contrast-Enhanced CT Protocols Indicated when alternative intra-abdominal surgical pathology is highly suspected over isolated renal colic. Retains diagnostic capability to identify urinary tract stones >3 mm even within contrast-enhanced phases. NCCT Structural Architecture Limitations Standard stone protocol CT scans are executed in a prone position without IV contrast enhancement. It does not opacify the ureteral lumen. Presents a cumulative radiation exposure penalty when utilized serially across recurrent ED presentations. POCUS / Radiology Ultrasound Direct stone visualization capabilities are modest, operating at approximately 50% to 60% sensitivity, and is highly dependent on anatomical positioning at the extreme proximal ureter or the UVJ. Secondary obstruction tracking: Demonstration of hydronephrosis operates at a high sensitivity of approximately 80%. POCUS Clinical Utility Metrics Eliminates ionizing radiation exposure and allows immediate, rapid real-time execution directly at the patient’s bedside. Confirmation of significant hydronephrosis within a classic clinical presentation yields high post-test probability for stone presence while lowering suspicion for vascular catastrophes like a AAA. KUB Radiography Extremely poor overall diagnostic sensitivity, hovering around 57%. Fails to image radiolucent configurations (pure uric acid matrices) or small stones measuring

Dr. Lorenzo Tomé conversa com Bruno Colantoni, cardiologista e presidente do Colégio Brasileiro de Medicina de Estilo de Vida (CBMEV), sobre uma das transições mais importantes da medicina contemporânea: sair do modelo de tratar doenças para construir saúde de fato, e o que isso significa para a carreira e o consultório do médico. O episódio parte de um dado que não dá pra ignorar: 75% das mortes no Brasil e no mundo vêm de doenças crônicas não transmissíveis, e o modelo de consulta avulsa não foi feito para tratar esse perfil de paciente. A conversa passa pela origem da especialidade nos Estados Unidos, pelos seis pilares da MEV, pela ciência da mudança de comportamento e pelo processo completo de certificação internacional. Mas também vai além disso trazendo a discussão sobre por que o paciente paga caro pela caneta emagrecedora e não paga pela consulta, o que isso revela sobre percepção de valor, e como o médico pode reposicionar a sua entrega dentro de um mercado de wellness que movimenta R$ 100 bilhões por ano no Brasil. Se você já sabe que precisa entregar mais ao paciente, mas ainda não encontrou a estrutura clínica e de negócio para fazer isso, esse episódio aponta o caminho. O background do Bruno Colantoni Bruno Colantoni é médico cardiologista formado pela Faculdade de Medicina de Marília, com residência em Clínica Médica, Cardiologia e Ecocardiografia pela Unicamp. Construiu carreira como cardiologista clínico, sócio de clínica própria, e ao longo do processo viveu na pele a transformação que hoje ensina: partiu de um quadro de obesidade, sedentarismo e triglicérides de 700 mg/dL para emagrecer 30 kg e descobrir, a partir da própria experiência, o impacto real dos hábitos de vida nos desfechos clínicos. Em 2018, participou de um curso de Lifestyle Medicine em Harvard, onde teve contato com os fundadores do Colégio Brasileiro de Medicina de Estilo de Vida. Desde então, dedica sua carreira à difusão e consolidação da MEV no Brasil, hoje como presidente do CBMEV e parceiro estratégico da SD Escola na capacitação dos médicos em medicina de estilo de vida. Entre na Comunidade SD no WhatsApp e tenha conteúdo gratuito todos os dias sobre negócios médicos. Acesse Assista esse episódio também em vídeo no Youtube no nosso canal Saúde Digital Podcast! Acesse os episódios anteriores! SD358 - Upsell ético no consultório: mercado de wellness sem "empurroterapia" SD357 - As consultas avulsas estão falindo SD356 - O que ninguém lhe ensinou sobre sucessão na medicina Musica: Declan DP - Climb Music © Copyright Declan DP 2018 - Present. https://license.declandp.info | License ID: DDP1590665  

En este episodio de Hemispherics hablamos sobre el daño axonal difuso tras un traumatismo craneoencefálico, una de las formas de lesión cerebral más frecuentes y, al mismo tiempo, más difíciles de comprender desde la clínica y la neuroimagen convencional. A lo largo del episodio revisamos cómo las fuerzas de aceleración y rotación pueden producir una lesión de desconexión en las redes cerebrales, profundizando en conceptos como la axotomía secundaria, la neuroinflamación, la vía del SARM1 o la lesión axonal traumática. También abordamos qué sabemos actualmente sobre resonancia magnética, tensor de difusión y biomarcadores como GFAP, UCH-L1 o neurofilamento ligero. Más allá de la biología, el episodio intenta trasladar todo esto a la realidad clínica y terapéutica. Hablamos de las expresiones cognitivas, conductuales y motoras que pueden aparecer en estos pacientes, de las limitaciones actuales del pronóstico y de cómo entender el daño axonal difuso no como una única lesión focal, sino como una alteración dinámica de redes cerebrales. Referencias del episodio: 1. Adams, J. H., Doyle, D., Ford, I., Gennarelli, T. A., Graham, D. I., & McLellan, D. R. (1989). Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology, 15(1), 49–59. https://doi.org/10.1111/j.1365-2559.1989.tb03040.x (https://pubmed.ncbi.nlm.nih.gov/2767623/). 2. Bayley, M. T., Janzen, S., Harnett, A., Teasell, R., Patsakos, E., Marshall, S., Bragge, P., Velikonja, D., Kua, A., Douglas, J., Togher, L., Ponsford, J., & McIntyre, A. (2023). INCOG 2.0 Guidelines for Cognitive Rehabilitation Following Traumatic Brain Injury: Methods, Overview, and Principles. The Journal of head trauma rehabilitation, 38(1), 7–23. https://doi.org/10.1097/HTR.0000000000000838 (https://pubmed.ncbi.nlm.nih.gov/36594856/). 3. Castaño-Leon, A. M., Sánchez Carabias, C., Hilario, A., Ramos, A., Navarro-Main, B., Paredes, I., Munarriz, P. M., Panero, I., Eiriz Fernández, C., García-Pérez, D., Moreno-Gomez, L. M., Esteban-Sinovas, O., Garcia Posadas, G., Gomez, P. A., & Lagares, A. (2022). Serum assessment of traumatic axonal injury: the correlation of GFAP, t-Tau, UCH-L1, and NfL levels with diffusion tensor imaging metrics and its prognosis utility. Journal of neurosurgery, 138(2), 454–464. https://doi.org/10.3171/2022.5.JNS22638 (https://pubmed.ncbi.nlm.nih.gov/35901687/). 4. Frati, A., Cerretani, D., Fiaschi, A. I., Frati, P., Gatto, V., La Russa, R., Pesce, A., Pinchi, E., Santurro, A., Fraschetti, F., & Fineschi, V. (2017). Diffuse Axonal Injury and Oxidative Stress: A Comprehensive Review. International journal of molecular sciences, 18(12), 2600. https://doi.org/10.3390/ijms18122600 (https://pubmed.ncbi.nlm.nih.gov/29207487/). 5. Geiger, P., Gmeiner, R., Schön, V., Petr, O., Thomé, C., & Pinggera, D. (2025). Timing of Magnetic Resonance Imaging (MRI) in Moderate and Severe TBI: A Systematic Review. Journal of clinical medicine, 14(12), 4078. https://doi.org/10.3390/jcm14124078 (https://pubmed.ncbi.nlm.nih.gov/40565823/). 6. Henninger, N., Bouley, J., Sikoglu, E. M., An, J., Moore, C. M., King, J. A., Bowser, R., Freeman, M. R., & Brown, R. H., Jr (2016). Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1. Brain : a journal of neurology, 139(Pt 4), 1094–1105. https://doi.org/10.1093/brain/aww001 (https://pubmed.ncbi.nlm.nih.gov/26912636/). 7. Johnson, V. E., Stewart, W., & Smith, D. H. (2013). Axonal pathology in traumatic brain injury. Experimental neurology, 246, 35–43. https://doi.org/10.1016/j.expneurol.2012.01.013 (https://pubmed.ncbi.nlm.nih.gov/22285252/). 8. Lagares, A., de la Cruz, J., Terrisse, H., Mejan, O., Pavlov, V., Vermorel, C., Payen, J. F., & of the BRAINI participants and investigators (2024). An automated blood test for glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) to predict the absence of intracranial lesions on head CT in adult patients with mild traumatic brain injury: BRAINI, a multicentre observational study in Europe. EBioMedicine, 110, 105477. https://doi.org/10.1016/j.ebiom.2024.105477 (https://pmc.ncbi.nlm.nih.gov/articles/PMC11647500/). 9. Mac Donald, C. L., Dikranian, K., Song, S. K., Bayly, P. V., Holtzman, D. M., & Brody, D. L. (2007). Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. Experimental neurology, 205(1), 116–131. https://doi.org/10.1016/j.expneurol.2007.01.035 (https://pubmed.ncbi.nlm.nih.gov/17368446/). 10. Mac Donald, C. L., Yuh, E. L., Vande Vyvere, T., Edlow, B. L., Li, L. M., Mayer, A. R., Mukherjee, P., Newcombe, V. F. J., Wilde, E. A., Koerte, I. K., Yurgelun-Todd, D., Wu, Y. C., Duhaime, A. C., Awwad, H. O., Dams-O'Connor, K., Doperalski, A., Maas, A. I. R., McCrea, M. A., Umoh, N., & Manley, G. T. (2025). Neuroimaging Characterization of Acute Traumatic Brain Injury with Focus on Frontline Clinicians: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Imaging Working Group. Journal of neurotrauma, 42(13-14), 1056–1064. https://doi.org/10.1089/neu.2025.0079 (https://pubmed.ncbi.nlm.nih.gov/40393517/). 11. Muehlschlegel, S., Rajajee, V., Wartenberg, K. E., Alexander, S. A., Busl, K. M., Creutzfeldt, C. J., Fontaine, G. V., Hocker, S. E., Hwang, D. Y., Kim, K. S., Madzar, D., Mahanes, D., Mainali, S., Meixensberger, J., Sakowitz, O. W., Varelas, P. N., Weimar, C., & Westermaier, T. (2024). Guidelines for Neuroprognostication in Critically Ill Adults with Moderate-Severe Traumatic Brain Injury. Neurocritical care, 40(2), 448–476. https://doi.org/10.1007/s12028-023-01902-2 (https://pubmed.ncbi.nlm.nih.gov/38366277/). 12. Ponsford, J. L., Downing, M. G., Olver, J., Ponsford, M., Acher, R., Carty, M., & Spitz, G. (2014). Longitudinal follow-up of patients with traumatic brain injury: outcome at two, five, and ten years post-injury. Journal of neurotrauma, 31(1), 64–77. https://doi.org/10.1089/neu.2013.2997 (https://pubmed.ncbi.nlm.nih.gov/23889321/). 13. Sassani, M., Ghafari, T., Arachchige, P. R. W., Idrees, I., Gao, Y., Waitt, A., Weaver, S. R. C., Mazaheri, A., Lyons, H. S., Grech, O., Thaller, M., Witton, C., Bagshaw, A. P., Wilson, M., Park, H., Brookes, M., Novak, J., Mollan, S. P., Hill, L. J., Lucas, S. J. E., … Fernández-Espejo, D. (2025). Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury. Brain communications, 7(2), fcaf120. https://doi.org/10.1093/braincomms/fcaf120 (https://pubmed.ncbi.nlm.nih.gov/40241788/). 14. Siedler, D. G., Chuah, M. I., Kirkcaldie, M. T., Vickers, J. C., & King, A. E. (2014). Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments. Frontiers in cellular neuroscience, 8, 429. https://doi.org/10.3389/fncel.2014.00429 (https://pubmed.ncbi.nlm.nih.gov/25565963/). 15. Smith, D. H., Hicks, R., & Povlishock, J. T. (2013). Therapy development for diffuse axonal injury. Journal of neurotrauma, 30(5), 307–323. https://doi.org/10.1089/neu.2012.2825 (https://pubmed.ncbi.nlm.nih.gov/23252624/). 16. Wofford, K. L., Loane, D. J., & Cullen, D. K. (2019). Acute drivers of neuroinflammation in traumatic brain injury. 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Matching phenotype to genotype at scale could transform how rare diseases are found, understood, and treated. Komodo Health has partnered with GeneDx to build one of the most comprehensive longitudinal rare disease datasets ever assembled. John Wollman, head of revenue strategy at Komodo Health, discusses how Komodo's longitudinal real‑world data on more than 330 million de-identified U.S. patient journeys, combined with GeneDx's genomic testing and rich phenotypic information, can shorten diagnostic odysseys, rapidly enable natural history studies, and help stakeholders across the rare disease continuum make smarter and faster decisions for people living with rare diseases.

Wednesday, May 6, 2026 - Week 19   Congrats to GETA, CURE SYNGAP1 Australia & CAMP4 for a great weekend. https://www.linkedin.com/posts/syngap1-epilepsy-ugcPost-7457791427486466048-j8SB   WEBINARS! CURE-ID Webinar tomorrow! Register now. Thu May 7, 2026 1:30pm – 3pm (PDT) cureSYNGAP1.org/cureID    Next week, especially NY families, while you are registering, please make sure to go to this one with Dr. Buxbaum from Mt. Sinai. curesyngap1.org/seaver https://www.linkedin.com/posts/curesyngap1_curesyngap1-syngap1-rarediseaseresearch-activity-7457507565527044096-dDEK   Longitudinal Data Matters - Every six months or more!   Study list! CURE SYNGAP1 CONNECT http://curesyngap1.org/connect Citizen Health https://www.citizen.health/ai-advocate/syngap1 Combined Brain ProMMiS https://www.linkedin.com/feed/update/urn:li:activity:7450196488300728320 & Rare-X, the same week. OR DSC. #S10e CURE-ID for Drug responses. Webinar: Thu May 7, 2026 1:30pm – 3pm (PDT) cureSYNGAP1.org/cureID   6th ANNUAL SPRINT FOR SYNGAP1, we raised over $300k! (Gross) Thank you Tavillas for raising over $170k this will go to the Missense fund. We spent over $¼M on missense last year.   Thank you Emily Barnes for hosting a New England event for families. https://www.linkedin.com/posts/ecarlisle_we-had-an-incredible-sprint-for-syngap-ugcPost-7457845816502845440-nJCd   Thank you to Sara and Sarah for the Virginia event.  GREAT WORK. https://www.linkedin.com/posts/sarah-sakly-648544337_syngap1-raredisease-curesyngap1-ugcPost-7456869206341464065-VESz   Thank your Rifton for the donation of the tricycle.  Congratulations Matthew! https://www.linkedin.com/posts/curesyngap1_syngap1-curesyngap1-sprint4syngap-activity-7457806850676281344--JR-   Thank you to the Edouard Family! cureSYNGAP1.org/Crafts26 https://www.linkedin.com/posts/curesyngap1_curesyngap1-syngap1-craftsforacure-activity-7457211260242411520-ekPz   INAUGURAL SF NIGHT OF IMPACT, CA – 22 days Join us this is our only Gala for 2026! cureSYNGAP1.org/SF26   5TH SCRAMBLE FOR SYNGAP, SC – 150 days Classic case of a small event becoming an institution! cureSYNGAP1.org/Scramble26   USA: use your ICD-10, F78.A1: https://onlinelibrary.wiley.com/doi/10.1002/epi.70142   PUBMED Pubmed 2026 is at 27. +10 vs the week. (61 last year was +9) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2026-2026&sort=date   SOCIAL MATTERS 4,931 LinkedIn.  https://www.linkedin.com/company/curesyngap1 1.56k YouTube.  https://www.youtube.com/@CureSYNGAP1 11.1k Twitter https://twitter.com/cureSYNGAP1 45k Insta https://www.instagram.com/curesyngap1   $CAMP closed at $3.97 Friday. https://www.google.com/finance/beta/quote/CAMP:NASDAQ   Like and subscribe to this podcast wherever you listen. https://curesyngap1.org/podcasts/syngap10 Episode 206 of #Syngap10 #CureSYNGAP1 #Podcast

Longitudinal decline in upper-limb range of motion in adults with cerebral palsyErika Cloodt, Jenny Hedberg-Graff, Anna Lindgren, Marianne Arner, Evgenia Manousaki, Katina Pettersson, Elisabet Rodby-BousquetAbstractAim: To analyse longitudinal changes in passive range of motion (ROM) in the upper limb in adults with cerebral palsy (CP).Method: Passive ROM for shoulder abduction and flexion, supination, and elbow and wrist extension was analysed in a longitudinal cohort of adults aged 16 to 76 years from the Swedish CP registry. Individual ROM trajectories and mean ROM curves were calculated using the Manual Ability Classification System (MACS). A mixed-effects model was used to examine changes over 3 to 13 years 7 months.Results: In total, 1395 adults with CP were analysed (769 males, 626 females; median age 26 years). A continuous decline in shoulder ROM, supination, and wrist extension was observed across all MACS levels. Decline rates differed between MACS levels for shoulder flexion, elbow extension, and wrist extension, with steeper declines at higher MACS levels (levels IV and V). Adults classified in lower MACS levels (I and II) had greater initial ROM and slower declines compared to adults classified in higher MACS levels.Interpretation: Upper-limb ROM continuously declined in adults with CP, particularly at higher MACS levels. The varied decline rates highlight the need for tailored interventions and systematic follow-up to maintain ROM and functional ability, especially among individuals at higher risk.

In Season 11 Episode 8, Hayley Spira‑Bauer sits down with Christopher Hull, Co-founder & President at Otus, to explore how meaningful data use can restore time, clarity, and humanity to teaching. A former middle school teacher, Chris shares how mentors helped him find his voice and why classroom frustrations—especially inefficient, narrative‑driven problem‑solving meetings—sparked the idea for Otis. He explains how a comprehensive, longitudinal student profile enables educators to move beyond fragmented storytelling to actionable insights, helping schools identify root causes, respond thoughtfully to parent concerns, and focus on what matters most: student engagement, motivation, and growth over time.  

We need a “human in the loop” in mid-revenue cycle work, experts say. What they fail to answer is the more interesting question:  Where in the loop, exactly?Back-end AI fact-checker? Front-end query authorizer? Or, maybe something like my current OTR guest Penny Jefferson envisions: Medical record maestro. The end-to-end connectedness of the medical record, evolving API standards, increased use of prior authorization, episode-based reimbursement models, and review of all of this by AI and other tools makes documentation cohesion more important than ever.  CDI is changing with the times, but often not fast enough. It must change, or risk stagnation and possible extinction. The ready availability of vast amounts of information in the EHR and AI-enabled reviews and audits means a slip in a diagnosis can result in a big DRG downgrade or denial of stay altogether. But an AI powered enabled CDI maestro conducting the show can make a record strong, front to back. Penny has been writing like a fiend about many of these and other related topics for LinkedIn and the likes of ICD-10 Monitor--which is what led her back to the hot seat of the Off the Record studio. Listen in as we discuss:  A day in the life of: Penny's evolving role at UCDavis Her take on today's CDI work, where is it coming up short and/or at risk of being automated away? UR function/medical necessity and how CDI can assist case management without igniting a turf war. “Longitudinal episode integrity”: Episode-based bundled payments (TEAM, etc.) and how they shift chart review beyond discrete diagnosis review to breadth APIs and FHIR standards: Issues with fields that don't match throughout the medical record leading to denials, bringing it home with an encephalopathy example Where does CDI need to upskill to meet these new demands? Does the “traditional” chart review/query role need to change ... or do we need an entirely new role to evolve to meet these demands? And what about productivity metrics? Addressing the elephant in the room. Where is the human in the loop? For example: should a human review every AI query before it goes out? Spend more time on high dollar, 5+ day stays? Tiebreak a co-equal dx? Updates on admit type. Listeners might recall our previous show on this topic, with  loose NUBC definitions leading to urgent vs. elective categorization to minimize impact on quality metrics. Other fun stuff you only get on #OTR 

This episode features Dr Catriona Mayland (University of Sheffield, UK. Sheffield Teaching Hospitals NHS Foundation Trust, UK. Palliative Care Unit, University of Liverpool, UK).   What is already known on this topic? The disease trajectory for people with incurable head and neck cancer is unpredictable. This cancer subgroup has high healthcare utilisation even in the last months of life.   What this paper adds Patients, caregivers and healthcare professionals consistently reported systemic variability in healthcare experiences for those with incurable head and neck cancer. Improving access to symptom relieving medications, helping more with advocacy, and developing ways to improve caregivers' preparedness reflect areas for improvement across the disease trajectory. Information needs change over time, with initial overload, but then complexities relating to advance care planning developing later due to the unpredictable nature of the disease.   Implications for practice, theory or policy Solutions include cancer centres adopting more accessible, inclusive means of communication and providing patients and families with reliable contact points for key healthcare professionals. Developing strategies or interventions to improve caregivers' preparedness should incorporate both caregivers and relevant healthcare professionals to ensure the technical aspects of care can be addressed.   Full paper available from:     https://journals.sagepub.com/doi/10.1177/02692163261416267   If you would like to record a podcast about your published (or accepted) Palliative Medicine paper, please contact Dr Amara Nwosu:  a.nwosu@lancaster.ac.uk

Most of medicine is built around snapshots. You feel something, you test for it, and by the time you find it, you're already behind. But what if the problem isn't the test—it's how we use it? In this episode, I sit down with physicist and imaging pioneer Dr. Daniel Sodickson, Chief Medical Scientist at Function Health and author of The Future of Seeing. We break down why tools like MRI are shifting from one-time scans to something far more powerful: tracking your health over time. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we cover: • Why waiting for symptoms puts you behind—and how to get ahead • What an MRI can reveal about your body that bloodwork can't • How tracking your health over time helps you catch problems sooner • Why having a baseline could change the way you make health decisions • What it means to shift from reacting to disease to actually predicting it When you stop looking at a single result and start looking at patterns, you can catch changes earlier, reduce false alarms, and better predict where your health is headed. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, Maui Nui, Sunlighten, Paleovalley, Fatty15 and BIOptimizers. Head to boncharge.com/hyman and use code HYMAN for 15% off. Go to mauinuivenison.com/hyman to claim your free 6-pack of their Wild Axis Venison Jerky Sticks. Visit sunlighten.com and use code HYMAN to save up to $1600 today! Head to paleovalley.com/hyman to save 15% off your first order today. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. (0:00) Introduction and overview of modern medical imaging (3:26) Discussion with Dr. Daniel K. Sodickson begins (3:45) Full body MRIs: Benefits, risks, and the inspiration behind "The Future of Seeing" (7:52) Extending senses and paradigm shifts in imaging technology (14:55) Longitudinal imaging and its benefits (19:17) Future of personalized health data and imaging technology (23:54) Addressing information overload and reducing false positives through AI (28:33) Cost, accessibility, and innovations in imaging techniques (32:00) Vision for ubiquitous and continuous health scanning (33:30) Imaging vs. blood work: Comprehensive health assessment (35:29) Real-life examples and early detection through imaging (39:27) Historical context and real-time health data collection (41:46) Who should get baseline MRIs and scan frequency (47:26) The everywhere scanner: Future implications and cancer detection (52:35) Medical intelligence and transforming health monitoring (57:47) Preventive measures, early detection, and course correction (1:00:30) Medical intelligence labs and the future of healthcare (1:03:32) Future of personal data-driven healthcare and closing remarks

Rubicon - Healthcare Executive & thought Leader Dr, Darren Wethers my former CMO calls in from Arizona to discuss mentorship, clinical prowess and the state of current Medicare & Medicaid

Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting on alcohol usage. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the April issue, which focuses on subjects related to substance use disorders. 00:57     What did you discover about the long term effects of using a personal blood alcohol monitor? 03:12     Do health monitoring devices actually change behaviors? 04:10     What did your cohort look like? 08:49     Disparate impact of monitoring on heavy drinkers and light drinkers 11:36     Clinical implications 14:34     Limitations 15:46     Avenues for further research 18:39     Kalin interview 18:46     Lu et al. 24:00     Wittekind et al. 29:50     Nicholson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

In this Bright Spots in Healthcare episode, host Eric Glazer brought together payer and provider leaders to examine a major shift underway in specialty care. Historically, specialty models have been built around episodic intervention, stepping in after a condition has progressed. But as organizations take on greater accountability for outcomes and cost, that model is becoming harder to sustain. The conversation explored how AI, earlier signal detection, and more connected care models can help organizations identify risk sooner, guide members more effectively, and support better outcomes over time. Our guests include: Saria Saccocio, MD, Chief Medical Officer, Essence Healthcare  Ross Lagerblade, Vice President, Value Based Strategies, Humana Mary O'Connor, MD, Chief Medical Officer & Co-Founder, Vori Health   Together, they explored: How specialty care is evolving from reactive, episode-based intervention to models built around continuous visibility and earlier action How organizations are identifying risk that never shows up in traditional data, and what it takes to surface and act on those blind spots How leading plans are redesigning the member experience to create clearer, more guided pathways through complex specialty care journeys What it looks like to use AI and new data sources to scale outreach, triage, and coordination without increasing operational burden How clinically grounded models are ensuring members are directed to the right level of care at the right time, avoiding unnecessary escalation What it takes to align care delivery, incentives, and measurement around sustained outcomes rather than isolated interventions This episode offers an inside look at how leaders are building more proactive, coordinated specialty care models, and what it takes to make them work in practice. Panelist Bios: https://www.brightspotsinhealthcare.com/events/ai-and-specialty-vbc-moving-from-episodic-care-to-longitudinal-outcomes/   Download the Episode Guide: Get key takeaways and expert highlights to help you apply lessons from the episode. https://www.brightspotsinhealthcare.com/wp-content/uploads/2026/03/EpisodeGuideBrightSpotsinHealthCare032626.pdf Key Insights Summary: Find key insights from the discussion and guest takeaways from the conversation. https://www.brightspotsinhealthcare.com/wp-content/uploads/2026/03/Key-Insights-03-26-26.docx.pdf Resources:  Report: Moving Specialty Care Upstream: From Episodic Intervention to Longitudinal Outcomes This companion report from Vori Health explores how physician-led, longitudinal care models are helping organizations identify risk earlier, guide members more effectively, and improve outcomes over time. Drawing on real-world implementation, it highlights how combining clinical expertise with data, AI, and coordinated care pathways can shift specialty care from reactive treatment to continuous management. Inside, you'll find insights on: Extending specialty care beyond traditional encounters to support members earlier in their journey Designing clinically grounded care pathways that guide members to the right level of care at the right time Using data, wearables, and AI to surface risk that is not visible in traditional workflows Reducing unnecessary escalation, procedures, and downstream cost through earlier intervention Building scalable models that combine centralized coordination with physician-led care delivery Why longitudinal accountability is becoming essential as expectations for outcomes, experience, and cost continue to rise To request your copy, reach out to show producer Nicole Roberts at nroberts@brightspotsventures.com Thank You to Our Episode Partner,  Vori Health By combining a physician-led care model with data-driven insights and longitudinal support, Vori Health is helping extend specialty care beyond episodic encounters and into continuous, whole-person care. In addition to improving access, Vori Health drives better outcomes, stronger member engagement, and meaningful reductions in unnecessary procedures and total cost of care. You can learn more at vorihealth.com. Schedule a Meeting with a Vori Health Leader: To explore how Vori Health can support your organization in delivering physician-led, longitudinal specialty care and guiding members earlier to the right level of care, reach out to show producer Nicole Roberts at nroberts@brightspotsventures.com to schedule a conversation with a senior leader from Vori Health. About Bright Spots Ventures: Bright Spots Ventures is a healthcare strategy and engagement company that creates content, communities, and connections to accelerate innovation.   We help healthcare leaders discover what's working, and how to scale it. By bringing together health plan, hospital, and solution leaders, we facilitate the exchange of ideas that lead to measurable impact. Through our podcast, executive councils, private events, and go-to-market strategy work, we surface and amplify the "bright spots" in healthcare, proven innovations others can learn from and replicate. At our core, we exist to create trusted relationships that make real progress possible. Visit our website at www.brightspotsinhealthcare.com.

Send a textWe explore  findings from three recent scientific studies that show how flexible expectations, strong relationships, and emotional meaning shape a lifetime of sexual satisfaction in marriage. Bouchard KN, Cormier M, Huberman JS, Rosen NO. Sexual script flexibility and sexual well-being in long-term couples. Journal of Sexual Medicine. 2023. Tavares IM, Rosen NO, Heiman JR, Nobre PJ. Longitudinal associations between relational and sexual well-being. Family Process. 2024. Henninger W, Heinz M, Taylor N. Love, Sex & Aging. Social Sciences. 2025.Warning: We cover necessary and important topics about the marriage relationship and sex. We use frank language without being crude or crass. Our approach is biblical and wholesome, but not intended for singles — especially not for children.Additional info:Ladies, make your voice and experience heard, take part in new sex research: The Lived Experience of Marital Sex: Women's Perspectives -- www.surveymonkey.com/r/QRWQPWKJoin us at the Intimate Covenant Annual Marriage Retreat -- details and registration: www.intimatecovenant.com/retreatRiverHills Retreat Marriage Enrichment Weekend -- Hayden, Alabama; April 18th. Register here: intimatecovenant/alabamaPlease support these companies that support Intimate Covenant:Married Dance — https://marrieddance.com/?aff=29 We're a Christian-friendly, marriage-centered sex toy and marital aid store for couples that's nudity-free.  Shop from this link for special savings and part of your purchase will support Intimate Covenant.  Coconu — http://www.coconu.com Coconu is committed to helping people lead healthier, happier lives by offering 100% safe and organic personal care products.  Your purchase helps support Intimate Covenant AND you get 15% OFF. Coupon Code: intimateconvenantDating Divas — https://thedatingdivas.myshopify.com?sca_ref=6278443.H6eWDeXGfx Strengthening marriages one date at a time. Shop from this link and your part of your purchase will help support Intimate Covenant. Check out their Sexy Subscription Boxes!Honoring Intimates — https://www.honoringintimates.com/?ref=INTIMATECOVENANT Modest and classy premium lingerie, model-free. Get 20% off and support Intimate Covenant with your purchase.Ginger & Peach — https://www.gingerandpeachlingerie.com/ Ginger & Peach lingerie is a Christian husband and wife owned brand bringing classy, model-free lingerie to the market. Get 10% off your order and support Intimate Covenant with code: “INTIMATECOVENANT"  To send your comments, questions and suggestions, go to our website: www.intimatecovenant.com/podcast and click on the button: “Contact the Podcast” for an ANONYMOUS submission form. Or, send an email: podcast@intimatecovenant.com   Thanks for sharing, rating, reviewing and subsSupport the show

Dr. Dave Rogawski interviews Dr. David Solomon on his research that sheds light on how key genomic alterations in high-grade glioma evolve over time and how these insights might inform therapeutic development.

Commentary by Dr.  Thomas Zegkos.

Cardiologist Bob Harrington talks to Mitch Elkind, chief science officer for Brain Health and Stroke at the AHA, about the heart-brain connection and why what's good for the brain is good for the heart. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association  https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078 Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546 Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands https://doi.org/10.1080/13814788.2017.1398318 Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study https://doi.org/10.1002/epd2.20253 Traumatic Brain Injury and Risk of Neurodegenerative Disorder https://doi.org/10.1016/j.biopsych.2021.05.025 Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence https://doi.org/10.3390/ijms222413488 The neuropathological diagnosis of Alzheimer's disease https://doi.org/10.1186/s13024-019-0333-5 Failed Semaglutide for Early Alzheimer's Not the End of the Road? https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration https://doi.org/10.1161/circulationaha.121.055018 Reduced regional cerebral blood flow in patients with heart failure https://doi.org/10.1002/ejhf.874 Heart-brain Interactions in Heart Failure https://doi.org/10.15420/cfr.2018.14.2 While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder https://doi.org/10.1001/jamapsychiatry.2024.3599 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356 "VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593 Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299 Unlocking Longevity: Aging Reimagined  https://www.medscape.com/viewarticle/1002241 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Dr. Ahmed Khalil is an MD-PhD currently serving his residency in radiology at the Institute of Neuroradiology at Charité University Hospital in Berlin. Originally from Sudan, he has been doing pioneering work on resting-state BOLD latency mapping, a technique that reveals flow deficits in the brain associated with stroke. His research demonstrates that this approach compares favorably with the current clinical gold standard of dynamic susceptibility contrast imaging using gadolinium, while capturing useful data in as little as two minutes.In this episode, Peter and Ahmed discuss his work translating advanced MRI techniques into clinical practice. They explore how BOLD latency mapping can detect perfusion deficits and compare with both traditional gadolinium-based methods and DTI for identifying stroke lesions. The conversation delves into the broader challenge faced by all promising research methods: what does it actually take to move from successful proof-of-concept to daily clinical practice on scanners around the world?Ahmed and Peter also talk about the cultural gap between research-level image processing and the clinical preference for minimally processed, interpretable data and how AI might help bridge that divide. Along the way, Ahmed shares valuable advice for MD-PhD students on the importance of collaboration, learning from diverse experts, and maintaining curiosity across disciplines.We hope you enjoy this episode!Chapters:00:00 - Introduction to Ahmed Khalil and His Work05:02 - Journey into Medicine and Radiology12:10 - The Challenges of Methods Development in Clinical Applications22:15 - Research on Resting State BOLD Latency37:27 - Clinical Implications of Perfusion Imaging in Stroke43:52 - Challenges in Clinical Implementation of New Imaging Techniques47:50 - The Role of AI in Radiology and Imaging Interpretation52:42 - Future Aspirations and Research Directions in Imaging01:01:03 - Collaborative Efforts in Physiologic MRI Book Project01:03:25 - Advice for Aspiring MD-PhD StudentsWorks mentioned:22:48 - https://pubmed.ncbi.nlm.nih.gov/23378326/(Lv et al., 2013 - First paper showing BOLD delay in stroke with Arno Villinger)23:08 - https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.015566(Khalil et al., 2017 - Stroke paper, Relationship between BOLD delay and DSC-MRI)23:08 - https://pubmed.ncbi.nlm.nih.gov/30334657/(Khalil et al., 2018 - JCBFM paper, Longitudinal changes in BOLD delay)39:00 - https://pubmed.ncbi.nlm.nih.gov/34323339/(Hu et al., 2021 - Human Brain Mapping paper with Daniel Margulies - ICA approach)Episode producers:Ömer Faruk Gülban, Xuqian Michelle Li

Longitudinal Look at Tooth Loss and Cognitive Decline among Older AdultsBy Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/longitudinal-look-at-tooth-loss-and-cognitive-decline-among-older-adults/Need CE? Start earning CE credits today at ⁠https://rdh.tv/ce⁠ Get daily dental hygiene articles at ⁠https://www.todaysrdh.com⁠ Follow Today's RDH on Facebook: ⁠https://www.facebook.com/TodaysRDH/⁠Follow Kara RDH on Facebook: ⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠Follow Kara RDH on Instagram: ⁠https://www.instagram.com/kara_rdh/⁠

Julavsnitt och Wille och Jacob går i det här avsnittet igenom en avhandling och en studie på hur sömnen verkar påverka kollegeidrottares prestation och skaderisk. Först diskuterar vi avhandlingen som är en stor databas där man följt amerikanska fotbollsspelare på college och tittat på sambandet mellan deras sömnvanor, prestation och skaderisk. Vill du läsa hela den avhandlingen så hittar du den här, Temporally precise relationships between sleep, performance and injury risk in collegiate football athletes. Halvägs in så hoppar vi vidare till en studie med snarlikt upplägg fast denna gång är det på basebollspelare på college. I den här studien har forskarna även undersökt om mängden sömn korrelerar med träningseffekten som spelarna får över tid. Denna studie hittar du här, Longitudinal assessment of objective sleep and power output in Division I collegiate baseball athletes. På Tyngre Träningssnacks instagram kan du hitta bilder relaterat till detta och tidigare avsnitt. Hålltider (00:00:00) Introsnack (00:07:48) Ny avhandling på korrelationen mellan sömn och skador, prestation (00:08:28) Oura ringa för att mäta sömnen hos collegeidrottare (00:13:33) Ett stort antal deltagare med en väldigt stor datamängd (00:18:06) Skador är dokumenterade på ett tillförlitligt vis (00:19:09) Lite sömn hade stor effekt på skaderisken (00:24:22) Det var en väldgit stor andel av idrottarna som sov för lite i den här studien (00:25:17) Hårdare träningspass ökade sömnbehovet natten efter (00:31:28) Sambandet mellan sömn och prestation dagen efter (00:43:48) Sömn och anpassning under en träningsperiod hos basebollspelare (00:47:39) Fokuserar vi för lite på sömnen som återhämtning i förhållande till det fokus som tex läggs på kost? (00:49:30) Idrottare ger sig för lite tid i sängen så de kan inte sova tillräckligt (00:51:47) Vad är tillräckligt med bra sömn?

Mallory Willsea sits down with David Weil, SVP for Strategic Services and CIO at Ithaca College, to unpack a bold thesis from his recent EDUCAUSE article. The two dive deep into how AI's most transformative potential in higher education isn't found in flashy tools or automations — it's in building a longitudinal view of the student experience. From data ethics and institutional silos to retention strategies and responsible design, this conversation challenges the status quo and outlines a human-first path forward for AI in higher ed.David's Article: Three Years In: Reflections and Considerations for the Next Chapter of AI in Higher Education - - - -Connect With Our Host:Mallory Willsea https://www.linkedin.com/in/mallorywillsea/https://twitter.com/mallorywillseaAbout The Enrollify Podcast Network:The Higher Ed Pulse is a part of the Enrollify Podcast Network. If you like this podcast, chances are you'll like other Enrollify shows too!Enrollify is made possible by Element451 — The AI Workforce Platform for Higher Ed. Learn more at element451.com. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We've gathered the NaPS lab to answer all your fascinating questions on all things sleep! A perfect bitesize episode to get stuck into the marvellous world of sleep. 1. How does sleep deprivation affect mental health? - Answered by Martha WawrzutaBunney, B. G. , Bunney, W. E. (2013). Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms. Biological PsychiatryFang, H., Tu, S., Sheng, J., Shao, A. (2018). Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. Journal of Cellular and Molecular Medicine2. What is narcolepsy? - Answered by Kyrillos MeshrekyLeschziner G., Narcolepsy: a clinical review, Practical Neurology 2014;14:323-3313. Does the full moon affect sleep? - Answered by Al Saqib MajumderCasiraghi, L. et al. (2021). Moonstruck sleep: Synchronization of human sleep with the moon cycle under field conditions. Chaput, J. P. et al. (2016). Are Children Like Werewolves? Full Moon and Its Association with Sleep and Activity Behaviors in an International Sample of Children. Sleep Medicine4. How does a smart watch track sleep? - Answered by Yan Wang5. What is orthosomnia? - Answered by Sophie Smith Baron, K.G., et al. (2017) Orthosomnia: Are some patients taking the quantified self too far? J Clin Sleep Med6. What is sleep regression and how long does it last? - Answered by Mo AbdellahiWeinraub, M. et al. (2012). Patterns of developmental change in infants' nighttime sleep awakenings from 6 through 36 months of age. Developmental PsychologyBruni O. et al. (2014) Longitudinal study of sleep behavior in normal infants during the first year of life. J Clin Sleep Med7. Does Magnesium Citrate help you sleep? - Answered by Dulni PeramunugamageMagnesium for sleep, Sleep Foundation, 20258. Does dark chocolate help you sleep? - Answered by Martha Nguyen Abdoli, E. et al. (2024). A clinical trial of the effects of cocoa rich chocolate on depression and sleep quality in menopausal women. Scientific reports,Garbarino, S., Garbarino, E., & Lanteri, P. (2022). Circadian Rhythm, Mood, and Temporal Patterns of Eating Chocolate: A Scoping Review of Physiology, Findings, and Future Directions. NutrientsMusic by Sergio Prosvirini from PixabayCheck out our NaPS website to find out more about the podcast, our research and events. This recording is the property of the Sleep Science Podcast and not for resale.

AEM E&T Podcast host Resa E. Lewiss, MD, interviews author Jessica Baez, MD

Today, I'm joined by Jannine Versi, co-founder & CEO of Elektra Health. Transforming menopause care at scale, Elektra Health partners with 40+ health plans to provide evidence-based virtual support through clinical visits, coaching, and community. In this episode, we discuss building the infrastructure for women's midlife and aging care. We also cover: Developing patient trust for the long term  Entering health plans with data-driven ROI The future of value-based care and women's health  Subscribe to the podcast → insider.fitt.co/podcast  Subscribe to our newsletter → insider.fitt.co/subscribe  Follow us on LinkedIn → linkedin.com/company/fittinsider   Elektra's Website: www.elektrahealth.com  Instagram: https://www.instagram.com/elektrahealth/  Facebook: https://www.facebook.com/elektrahealth  - The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart fitness ecosystem for fitness and health facilities. Fitt Talent: https://talent.fitt.co/  Consulting: https://consulting.fitt.co/  Investments: https://capital.fitt.co/   Chapters:  (00:00) Introduction  (01:50) Jannine's background (02:30) Elektra Health's origin story (03:45) Early telemedicine adoption (05:00) Evolution of menopause awareness and conversation (06:00) Expanding health plan partnerships  (06:40) Education and community platform strategy  (09:00) Building a digital home for menopause content  (10:30) Meeting patients where they are in their journey  (12:40) Platform architecture (14:15) Complex patient journeys across clinical and coaching  (16:10) Long-term patient relationship and trust-building  (18:35) Access as the core challenge in women's midlife health  (19:25) Breaking into health plan partnerships  (21:00) Employer demand driving health plan adoption  (22:20) Proving clinical and financial value  (24:20) The women's health conversation and stigma  (25:10) Longitudinal aging care  (27:30) Value-based care and the future of women's health  (28:55) Product roadmap (32:00) Mainstreaming menopause and midlife health topics  (33:45) Oscar Health partnership (35:30) Evidence-based approach without product monetization  (36:20) Conclusion  

Katharine Phillips joins host Catherine Glass to explore how brain circuitry, heritability, and visual processing abnormalities contribute to body dysmorphic disorder. Drawing on decades of clinical research, she discusses chronicity, recovery patterns, and how surgeons can better identify patients seeking aesthetic procedures for BDD. This episode unpacks the neurobiological and behavioural roots behind the disorder.  Timestamps:  01:05 – Clinical features  02:25 – Neurobiology  05:10 - Interventions  08:50 – Longitudinal research  11:10 – Patient insight 

It's World AMR Awareness Week (WAAW) and we have prepared a special episode in light of that. In this week's Communicable, Navaneeth Narayanan and Thomas Tängdén host Aula Abbara (London, UK), Guido Granata (Rome, Italy) and Tuomas Aro (Helsinki, Finland) to discuss the phenomenon of AMR in conflict and crisis zones. They elaborate on how difficult conditions and austere environments amplify the spread of AMR, drawing on findings from the ongoing conflicts in Ukraine, Gaza, Syria and other regions. Other topics covered include adapting antimicrobial stewardship and infection prevention and control (IPC) practices as well as the need for genuine political will and international collaboration to end conflicts and their exacerbation on AMR.This episode follows the webinar “Beyond the frontlines” organised by ESCMID's AMR Action Subcommittee for WAAW 2025, featuring the same guests, and is available on ESCMID Media. This Communicable episode was peer reviewed by Arjana Zerja of Mother Theresa University Hospital Centre, Tirana, Albania.  Related ESCMID and Communicable mediaESCMID Media, Part 1: Beyond the frontlines - tackling AMR in conflict and crisis zones, webinar Communicable episode 11: Nightmare series, part 2 – how to deal with carbapenemase producers Communicable episode 16: Climate change and infections – effects on clinical practice & sustainabilityResourcesTrainee Association of ESCIMD (TAE) Doctors without Borders (Médecins sans Frontières), Antibiogo, https://www.antibiogo.org/Doctors without Borders (Médecins sans Frontières), Mini-lab, https://fondation.msf.fr/en/projects/mini-lab Further ReadingAbbara A, et al. Unravelling the linkages between conflict and antimicrobial resistance. NPJ Antimicrob Resist. 2025. DOI: 10.1038/s44259-025-00099-yAbbara A, et al. A summary and appraisal of existing evidence of antimicrobial resistance in the Syrian conflict. Int J Infect Dis. 2018. DOI: 10.1016/j.ijid.2018.06.010Abu-Shomar R, et al. Multidrug-resistant Pseudomonas isolated from water at primary health care centers in Gaza, Palestine: a cross-sectional study. IJID Reg. 2025. DOI: 10.1016/j.ijregi.2025.100671Aldbis A, et al. The lived experience of patients with conflict associated injuries whose wounds are affected by antimicrobial resistant organisms: a qualitative study from northwest Syria. Confl Health. 2023. DOI: 10.1186/s13031-023-00501-4Aro T, et al. War on antimicrobial resistance: high carriage rates of multidrug-resistant bacteria among war-injured Ukrainian refugees. Clin Microbiol Infect. 2025. DOI: 10.1016/j.cmi.2025.07.010  Bazzi W, et al. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front Microbiol. 2020. DOI: 10.3389/fmicb.2020.00068 Dewachi O. War Biology and Antimicrobial Resistance: The Case of Gaza, AMR Insights, 2024.Granata G, et al. The impact of armed conflict on the development and global spread of antibiotic resistance: a systematic review. Clin Microbiol Infect. 2024. DOI: 10.1016/j.cmi.2024.03.029 Huang XZ, et al. Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. Epidemiol Infect. 2012. DOI: 10.1017/S0950268811002871Hujer KM, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006. DOI: 10.1128/AAC.00778-06Karah N, et al. Teleclinical Microbiology: An Innovative Approach to Providing Web-Enabled Diagnostic Laboratory Services in Syria. Am J Clin Pathol. 2022. DOI: 10.1093/ajcp/aqab160Keen EF 3rd, et al. Evaluation of potential environmental contamination sources for the presence of multidrug-resistant bacteria linked to wound infections in combat casualties. Infect Control Hosp Epidemiol. 2012. DOI: 10.1086/667382Murray CK, et al. Recovery of multidrug-resistant bacteria from combat personnel evacuated from Iraq and Afghanistan at a single military treatment facility. Mil Med. 2009. DOI: 10.7205/milmed-d-03-8008Petersen K, et al. Diversity and clinical impact of Acinetobacter baumannii colonization and infection at a military medical center. J Clin Microbiol. 2011. DOI: 10.1128/JCM.00766-10Scott P, et al. An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. Clin Infect Dis. 2007. DOI: 10.1086/518170Sensenig RA, et al. Longitudinal characterization of Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonizing and infecting combat casualties. Am J Infect Control. 2012. DOI: 10.1016/j.ajic.2011.03.025World Health Organization. Fourth WHO Global Evidence Review on Health and Migration stresses that equitable access to and appropriate use of antibiotics for refugees and migrants is essential to tackling Antimicrobial Resistance, News, 2022.

One-time stories inspire emotion; longitudinal stories build transformation. The most successful fundraisers don't just tell what happened, they connect the dots over time, showing progress, growth, and real impact. When donors see themselves within the story—woven into its chapters—they move from giving out of urgency to giving out of identity. Storytelling isn't about communication; it is communication. And when done longitudinally, it becomes the foundation for trust, loyalty, and transformational giving.

Longitudinal studies of how an individual's accent changes over the course of their life are hard to come by. Fortunately, Taylor Swift's decade-plus career-- and the numerous interviews she's given over those years-- has opened a window into our understanding of how and why dialect changes may occur on an individual level. We talk to Miski Mohamed and Matthew Winn (University of Minnesota) about their work analyzing the shifts in Taylor Swift's speech over the years.Associated paper:- Miski Mohamed and Matthew B. Winn. "Acoustic analysis of Taylor Swift's dialect changes across different eras of her career." J. Acoust. Soc. Am. 158, 2278–2289 (2025). https://doi.org/10.1121/10.0039052Read more from The Journal of the Acoustical Society of America (JASA).Learn more about Acoustical Society of America Publications.Music Credit: Min 2019 by minwbu from Pixabay. 

On this episode of JHLT: The Podcast, the Digital Media Editors host a discussion on the paper, "Impact of donor specific antibodies on longitudinal lung function and baseline lung allograft dysfunction."   They are joined by the first author, Muhtadi Alnababteh, MD, Assistant Professor at the University of Maryland and Staff Clinician at the National Institutes of Health, and senior author Michael Keller, MD, of the Pulmonary and Critical Care division at the University of Maryland.   The discussion explores: Common characteristics of patients who developed donor-specific antibodies (DSA) Differences in outcomes depending on when DSA developed Associations between the development of DSA and antibody-mediated rejection, and related time frames For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

BUFFALO, NY — November 5, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on September 10, 2025, titled “Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos.” In this study led by Myriam Fornage, from The University of Texas Health Science Center at Houston, researchers found that faster biological aging, measured by DNA-based epigenetic clocks, is associated with greater cognitive decline and higher risk of mild cognitive impairment (MCI) in Hispanic/Latino adults. The results highlight the potential of epigenetic clocks to track changes in brain health over time, helping improve early detection and monitoring of age-related cognitive problems. Cognitive decline and dementia are major public health concerns, especially among aging populations. In this study, researchers followed 2671 Hispanic/Latino adults (average age 57; 66% women) over a seven-year period. They measured each participant's biological age using epigenetic clocks and assessed their cognitive performance at two time points. “We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit 2 (V2).” Epigenetic clocks estimate biological age based on DNA chemical modifications, called methylation, that accumulate with age. The study evaluated five different clocks, including newer models like GrimAge and DunedinPACE, which are designed to more accurately reflect health-related aging. The researchers found that individuals with faster biological aging showed lower cognitive function and higher probability of developing MCI over time. Among the five clocks studied, newer models such as GrimAge and DunedinPACE showed the strongest associations with memory, processing speed, and overall brain health. These findings suggest that tracking changes in biological age over time may be more effective than relying on a single measurement to identify those at risk for cognitive impairment. Importantly, the associations between biological aging and cognitive decline remained significant even after accounting for other known risk factors such as education, language preference, and cardiovascular health. This supports the idea that epigenetic clocks capture unique biological processes that influence brain aging. The study also found that the impact of changes in biological age over time was comparable to that of APOE4, a well-established genetic risk factor for Alzheimer's disease. Overall, this is the first large-scale study to examine these associations in a Hispanic/Latino population, a group that is underrepresented in aging research. By identifying early biological signs of brain aging, this work highlights the potential of epigenetic clocks as tools for routine health assessments. Monitoring changes in these biological markers could help detect individuals at risk for cognitive decline and guide timely interventions to preserve brain health. DOI - https://doi.org/10.18632/aging.206317 Corresponding author - Myriam Fornage - Myriam.Fornage@uth.tmc.edu Abstract video - https://www.youtube.com/watch?v=kG0Y-F_sods To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Katarina Zeder, MD, PhD, joins CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss her research into the ways in which longitudinal pulmonary arterial pressure trajectories inform clinical outcome in patients undergoing kidney transplantation.  DOI: 10.1016/j.chest.2025.05.024 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Send us a textEver wondered what's actually inside a “homemade” dog diet—and whether it truly keeps dogs healthy? We sat down with researchers Drs. Janice O'Brien and Audrey Ruple from the Dog Aging Project to pull back the curtain on what owners are really feeding, what the data reveals, and how to make home-prepared meals complete and balanced without guesswork. The conversation starts with a major survey upgrade: moving from simple checkboxes to detailed free-text responses that capture real ingredients, supplements, and routines. That shift exposes a surprising truth—most DIY bowls contain nine to ten ingredients, far beyond chicken and rice, yet many still miss key nutrients for maintenance.We walk through the practical and the personal: how to take a smarter diet history in the exam room, what owners should ask before they shop, and which tools can reliably build balanced recipes. Instead of fear or food wars, we focus on action. Consulting a board-certified veterinary nutritionist, using validated recipe platforms, and leveraging commercial base mixes can transform care and confidence. We also explore the long game. Do incomplete diets quietly shape future health risks? Which deficiencies matter most over time? Longitudinal data from the Dog Aging Project aims to turn those open questions into guidance that protects joints, skin, metabolism, and longevity.There's another layer that deserves attention: diversity among human owners. While our canine cohorts are broad, our human samples often aren't. Culture, income, education, and access influence feeding choices, shopping habits, and follow-up care. Broadening who participates in pet nutrition research makes our recommendations more realistic and more fair. By the end, you'll have a clearer view of where homemade feeding succeeds, where it stumbles, and how to build a plan that meets your dog's needs today and supports health tomorrow.If this conversation helped you think differently about dog nutrition, subscribe, share with a friend who home cooks, and leave a quick review—your feedback helps more pet owners find science they can use.AJVR article: https://doi.org/10.2460/ajvr.25.06.0216INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

How are our kids actually spending their time — and is it aligned with what we value for our families' lives and for our children's well-being? This week, Amy and Margaret discuss: How sleep too often loses out to homework and activities Time tracking and the sobering truth it can show about how many hours a week our kids actually spend on screens How outdoor time and free play, too often in short supply, affects creativity, independence, and self-regulation Strategies for families to audit time, realign priorities, and invite kids into decision-making It's worth the effort to track how our time is actually spent. As Annie Dillard said: “How we spend our days is how we spend our lives.” Here are links to some of the resources we mention in the episode: Gretchen Livingston for Pew Research Center: The way U.S. teens spend their time is changing, but differences between boys and girls persist Cleveland Clinic: How Much Sleep Kids Need: Recommended Hours by Age Dahl KL, et. al: Time Playing Outdoors Among Children Aged 3-5 Years: National Survey of Children's Health, 2021. Yeshe Colliver et. al for Early Childhood Research Quarterly: Free play predicts self-regulation years later: Longitudinal evidence from a large Australian sample of toddlers and preschoolers Our Fresh Take with Christina Martin on How Children Learn Through Play Our Fresh Take with Lenore Skenazy, author of FREE-RANGE KIDS Our Fresh Take with Ginny Yurich, host of the 1000 Hours Outside podcast Our Fresh Take with Laura Vanderkam, time-tracking expert Sign up for the What Fresh Hell newsletter! Once a month you'll get our favorite recent episodes, plus links to other things to read and watch and listen to, and upcoming special events We love the sponsors that make this show possible! You can always find all the special deals and codes for all our current sponsors on our website: ⁠⁠⁠https://www.whatfreshhellpodcast.com/p/promo-codes/ Get 50% Off Monarch Money, the all-in-one financial tool at ⁠www.monarchmoney.com/FRESH Ready to raise money-smart kids? Start now with your first month FREE at acornsearly.com/FRESH! Head to GigSalad.com and book some awesome talent for your next party, and let them know that What Fresh Hell sent you. How kids spend time, kids and screen time, parenting priorities, unstructured play, outdoor play for kids, kids and sleep needs, family time management, limiting screen time, Annie Dillard quote parenting, homework vs sleep, raising independent kids, parenting podcast, What Fresh Hell episode, time tracking for families, free play benefits Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Talking Sleep, host Dr. Seema Khosla welcomes Dr. Doug Kirsch, Medical Director of Atrium Health Sleep Medicine and Clinical Professor in the Department of Neurology at Wake Forest School of Medicine, and Dr. Fariha Abbasi-Feinberg, president-elect of the AASM and private practice physician with Millennium Physician Group in Fort Myers, Florida, to introduce PLATO—a groundbreaking longitudinal assessment tool for obstructive sleep apnea. The Epworth Sleepiness Scale has been a cornerstone of sleep medicine practice for decades, yet clinicians universally acknowledge its limitations in capturing the full patient experience. Similarly, PAP adherence—while important and part of Medicare's MIPS program—tells only part of the story about treatment success. During his AASM presidency, Dr. Kirsch recognized the need for a more comprehensive metric and convened an expert advisory panel to develop a better solution. The conversation traces PLATO's development journey, which Dr. Rosen described as "Doug's baby with a prolonged gestation." Starting with 44 potential questions and utilizing the ICON methodology, the panel carefully refined the tool to capture domains beyond simple sleepiness—including quality of life, functional impairment, and symptom burden that the Epworth overlooks. Dr. Kirsch and Dr. Abbasi-Feinberg explain the validation process, how the tool discriminates between OSA severity levels, and why certain seemingly similar questions about sleepiness were all retained. The episode addresses practical implementation questions: How is PLATO scored? Why do the first two sections use 5-point scales while the final section uses 10 points? Is it free to use, and how does one access it? Will it integrate into electronic health record systems like Epic? Most importantly, how should clinicians use this tool—will it replace the Epworth for Medicare requirements, or does it serve a different purpose? The discussion also explores how PLATO relates to the recent AHRQ report on OSA treatment outcomes and why the tool focuses on patient-reported symptoms rather than solely cardiovascular endpoints. Dr. Kirsch shares his vision for PLATO's future, including hopes for foundation grants to further study the tool and demonstrate that treating OSA and its associated sleepiness meaningfully improves patient outcomes. Whether you're frustrated with current assessment limitations, interested in value-based care metrics, or seeking better ways to document treatment efficacy beyond adherence data, this episode provides essential insights into a tool that may reshape how we measure success in sleep medicine. Join us for this important discussion about moving beyond PAP adherence and Epworth scores to truly capture what matters to our patients.

In this special dyslexia-focused Essentials episode of Science of Reading: The Podcast, Susan Lambert pulls from past episodes to summarize everything you need to know about dyslexia, from experts Emily Lutrick, Ed.D.; Nadine Gaab, Ph.D.; Tim Odegard, Ph.D.; Sally Shaywitz, M.D.; and Francisco Usero-González, Ph.D. You'll also hear first-hand accounts from young people about their personal experiences with dyslexia, reading, and the education system. Even if you have little prior knowledge of dyslexia, you'll walk away from this episode with a foundational understanding of the condition, including what it is, what causes it, how to identify it, the importance of early screening, how it is a continuum, methods for intervention, and more.Show notes:ResourcesAccess free high-quality resources at our brand new professional learning page: http://amplify.com/science-of-reading/professional-learning Listen to these additional full-length episodes about dyslexia:Diagnosing dyslexia in multilingual learners, with Francisco Usero-GonzálezGrowing up with dyslexia, with Kareem Weaver, Margaret Malaika Weaver, and Elijah ValenciaDyslexia: Where we started; where we're going, with Sally ShaywitzDebunking the "gift" of dyslexia, with Tim OdegardA conversation about growing up with dyslexia, with Hadyn FlemingDyslexia and developmental trajectories, with Nadine GaabThe facts and myths of dyslexia, with Emily LutrickJoin our community Facebook Group: www.facebook.com/groups/scienceofreadingEpisode Timestamps*00:27 Introduction to SoR: Essentials01:02 Susan's personal connection with dyslexia02:53 Accounts from young people on their experience of dyslexia05:09 Defining dyslexia with Dr. Emily Lutrick06:53 Dyslexia as a reading disability with Dr. Nadine Gaab07:39 Three key characteristics of people with dyslexia with Dr. Tim Odegard09:42 Longitudinal study with Dr. Sally Shaywitz11:54 The causes of dyslexia13:09 Early identification and effective intervention15:22 Discrepancy model/Waiting to fail model16:35 How early is too early to screen for dyslexia18:37 How to know when a student is at risk for dyslexia21:54 Identifying risk factors in older students22:54 Decoding nonsense words24:27 The power of naming a struggle25:28 The importance of having a cohesive system in place26:43 Screening students in their home language with Dr. Francisco Paco Usero Gonzalez29:45 Dyslexia as a continuum33:41 Final thoughts from young people on dyslexia36:12 Preview of upcoming episode

Dr. Leonard Egede, Dr. Rebekah Walker, and Dr. Obinna Ekwunife from the Department of Medicine at the University of Buffalo, NY, describe their #research paper #published in Volume 17, Issue 8 of Aging-US, entitled “Longitudinal relationship between social and CVD risk factors in older adults with prediabetes: the HRS 2006-2016.” #interview #authorinterview #aging #prediabetes #cardiovascular #health #openaccess #openscience #peerreviewed #journal #publication #publishing #meded DOI - https://doi.org/10.18632/aging.206308 Corresponding author - Leonard E. Egede - legede@buffalo.edu Video interview - https://www.youtube.com/watch?v=1MSTk3GQAGA Video transcript - https://aging-us.net/2025/10/08/behind-the-study-social-and-cardiovascular-risk-factors-in-older-adults-with-prediabetes/ Abstract Background: This study examines how multiple social risk factors influence cardiovascular disease (CVD) risk control over time in older adults with prediabetes using a nationally representative cohort. Methods: Data from the Health and Retirement Study (HRS) included 5,086 U.S. adults aged 50+ with prediabetes. Five social risk domains (economic stability, environment, education, healthcare, and social context) were examined as independent variables, while CVD risk factors included glycemic control (HbA1c), systolic blood pressure (SBP), and cholesterol ratio (total cholesterol/high-density lipoprotein). Mixed-effects models assessed relationships between social risk factors and CVD outcomes, adjusting for age, gender, race, and marital status. Results: The sample had an average age of 68.6 years, with 60.2% female, and 70.97% identifying as non-Hispanic Black. Average HbA1c was 5.7, SBP 129.4, and cholesterol ratio 3.85. Limited education was consistently associated with increased CVD risk—HbA1c (β = 0.03, 95% CI: 0.01–0.06, p < 0.001), SBP (β = 4.34, 95% CI: 2.96–5.71, p < 0.001), and cholesterol ratio (β = 0.08, 95% CI: 0.01–0.16, p < 0.05) —in the fully adjusted model. Medication cost-related non-adherence was significantly associated with higher HbA1c levels (β = 0.03, 95% CI: 0.002–0.06, p < 0.05). Difficulty paying bills and lack of health insurance were both significantly associated with higher cholesterol levels (β = 0.03, 95% CI: 0.002–0.06, p < 0.05) and (β = 0.22, 95% CI: 0.15–0.30, p < 0.001), respectively. Conclusions: Social risk factors, particularly limited education, significantly impact CVD risk in older adults with prediabetes. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206308 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, prediabetes, social determinants of health, health equity, cardiovascular health, population health To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Trigger warning: This episode includes discussion of suicide in the context of researching measurable predictive indicators and the lack thereof in the context of cyber. Episode NotesDr Caputo's path from social psychology to applied security, including intelligence analysis and building a behavioural-science team at MITRE.What MITRE is: a not-for-profit operating six federally funded R&D centres that provide independent, public-interest research alongside government.Why early “indicator” hunting on endpoints often chased the last bad case; shifting to experiments and known-bad/created-bad data to learn patterns of behaviour change.The LinkedIn recruiter field experiment: ethically approved creation of recruiter personas, staged outreach in three messages, and follow-up interviews to understand reporting barriers.What user-activity monitoring can and cannot tell you; the role of human judgement and programme design.Insider-risk is not only “malicious users”: designing programmes for negligent, mistaken or outsmarted behaviours as well.Current lines of work include improving employee recognition and reporting of malicious elicitations and exploring whether insider-risk telemetry offers early signals of suicide risk.Why multidisciplinary teams beat solo efforts in insider-risk operations.About our guest:Dr. Deanna D. Caputo MITRE Insider Threat Research & Solutions profile: https://insiderthreat.mitre.org/dr-caputo/ LinkedIn: https://www.linkedin.com/in/dr-deanna-d-caputoPapers or resources mentioned in this episode:Caputo, D. D. (2024). Employee risk recognition and reporting of malicious elicitations: Longitudinal improvement with new skills-based training. Frontiers in Psychology. https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1410426/full MITRE Insider Threat Research & Solutions. (2025). Suicide risk and insider-risk telemetry overview. https://insiderthreat.mitre.org/suicide-risk/ MITRE. (2024). Managing insider threats is a team sport. https://www.mitre.org/news-insights/impact-story/managing-insider-threats-team-sport MITRE Insider Threat Research & Solutions. (2024). Capability overview two-pager (PDF). https://insiderthreat.mitre.org/wp-content/uploads/2024/06/MITREInTResearchSolutions-CapabilityTwoPager-24-0659_2024-02-01.pdf MITRE Insider Threat Research & Solutions. (2024). Insider Threat Behavioural Risk Framework two-pager (PDF). https://insiderthreat.mitre.org/wp-content/uploads/2024/06/MITREInTResearchSolutions-InTFramework_TwoPager-24-0674_2024-03-18.pdf

Commentary by Dr. Kriti Mittal.

According to analysis by Financial Times writer John Burn-Murdoch, something extraordinary has happened to Americans' personalities in the last decade. Longitudinal tests indicate that we've collectively become less extroverted, less agreeable, and more neurotic. The most significant thing Burn-Murdoch found is that measures of conscientiousness among young Americans appears to be in a kind of free fall. Today, John and I talk about his research. We discuss personality tests, the value of conscientiousness, and how the modern world might be scrambling our personalities by making us less interested in other people and more consumed with our own neurotic interiority. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: John Burn-Murdoch Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of The Dairy Podcast Show, Dr. Hinayah Rojas, from Purdue University, shares valuable insights into the rapidly evolving field of genomics in dairy cattle. Dr. Rojas breaks down the challenges and opportunities presented by longitudinal traits like milk production, discussing how genomic tools are helping to boost sustainability across the industry. Additionally, Dr. Rojas offers advice on balancing motherhood with a demanding professional life. Listen now on all major platforms!"The lactation curve is complex, but genomics allows us to select animals not only for higher milk production but also for better lactation persistence."Meet the guest: Dr. Hinayah Rojas de Oliveira is an Assistant Professor of Genomics and Animal Breeding at Purdue University. She holds a PhD in Animal Sciences, focusing on Genetics and Animal Breeding, from the Federal University of Viçosa in Brazil. Dr. Rojas has completed postdoctoral work at the University of Guelph and Purdue University and previously worked as a Geneticist at Lactanet Canada. Her research aims to develop statistical models that maximize genetic progress while preserving diversity in livestock species.Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(01:30) Introduction(02:35) Dr. Rojas's journey(08:52) Genomics in dairy cattle(11:55) Longitudinal traits(14:30) Genomic & efficiency(17:11) Sustainability & genomics(28:35) Final questionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo* Lallemand* Priority IAC* Evonik- ICC- AHV- Protekta- Natural Biologics- SmaXtec- Berg + Schmidt- dsm-firmenich

Well, well, well, it’s time to prove things.

Interview with Leila J. Mady, MD, PhD, MPH, author of Longitudinal Financial Toxicity and Quality of Life in Head and Neck Cancer. Hosted by Paul C. Bryson, MD, MBA. Related Content: Longitudinal Financial Toxicity and Quality of Life in Head and Neck Cancer

In this BJSM podcast, Dr Harvi Hart overview of the different types of body mass and body composition measurements, and they may impact common knee conditions, and what this means for clinicians, patients, and athletes. Harvi specializes in knee injuries and conditions, such as ACL injuries, patellofemoral pain, and osteoarthritis. Her research aims to develop targeted treatments that improve symptoms, mobility, and quality of life for individuals with knee conditions, using a combination of joint movement analysis, imaging, and clinical outcome measures. Links: Is body mass index associated with patellofemoral pain and patellofemoral osteoarthritis? A systematic review and meta-regression and analysis https://pubmed.ncbi.nlm.nih.gov/27927675/ Adiposity and cartilage lesions following ACL reconstruction: https://pubmed.ncbi.nlm.nih.gov/38631554/ Longitudinal changes in adiposity following anterior cruciate ligament reconstruction and associations with knee symptoms and function: https://pubmed.ncbi.nlm.nih.gov/38737984/ Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study https://pubmed.ncbi.nlm.nih.gov/31705199/

Do you know anyone who has extremely intense relationships—one minute totally in love with someone; the next, flying into a rage and calling them the worst person ever? It's possible that they have borderline personality disorder.Whatever that is. What is a “personality disorder”, anyway? How is one diagnosed? In this episode of The Studies Show, Tom and Stuart discuss a disorder that gets a lot of attention online, but which seems pretty tricky to define. And it's somehow both surprising and entirely predictable that Tom relates this disorder back to his favourite topic: the Reverend Thomas Bayes.The Studies Show is brought to you by Works in Progress magazine. On their Substack newsletter, you can find different styles of articles that aren't part of the main magazine, like this excellent walkthrough of nuclear power technology called “Nuclear Reactors for Dummies”. You can find that and much more at worksinprogress.news. Show notes* Mayo Clinic page on personality disorders* NHS page on Borderline Personality Disorder* Chimamanda Ngozi Adichie's 2021 essay “It is Obscene”* Tom's Unherd article on this controversy* 2009 paper on Dissociative Identity Disorder and its overlap with Borderline Personality Disorder* Comparison of patients with DID and BPD, with a discussion of the overlap* Pieces by people with BPD diagnoses who've regularly changed their dress/style* Tom's book on Bayesianism* Sceptical article about top-down effects on perception* Paper on the “predictive processing” theory of BPD* Scott Alexander article on the same topic* Twin study on the overlap between BPD and antisocial personality disorder, and potential sex differences* Longitudinal studies on whether people “age out” of BPD* People higher in “dark tetrad” traits are more likely to enjoy trolling people onlineCreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

In this week's episode Greg and Patrick explore both the challenges and the opportunities of age-period-cohort analysis when trying to understand the complexities of human behavior over time. Along the way they also discuss bachelor night, Dave Brubeck, pay phones, street lights, global nuclear war, lazy thinking, I'm not a crook, biking to grandmas, HMS Pinafore, the Beatles, aggressive mice, trash snakes, and getting high at A-Basin.Stay in contact with Quantitude! Web page: quantitudepod.org TwitterX: @quantitudepod YouTube: @quantitudepod Merch: redbubble.com

Once Dr. Ray Damadian had the idea to create a machine that used nuclear magnetic resonance to capture diagnostic data by scanning a human body, he still had to build it. And though he did, other scientists got credit for inventing the MRI.   Research: Bashir U, Rock P, Murphy A, et al. T2 relaxation. Reference article, Radiopaedia.org. https://doi.org/10.53347/rID-16494 Bellis, Mary. "A Guide to Magnetic Resonance Imaging (MRI)." ThoughtCo, Apr. 5, 2023, thoughtco.com/magnetic-resonance-imaging-mri-1992133 Bloch, Felix. “The Principle of Nuclear Induction.” Nobel Lecture. Dec. 11, 1952. https://www.nobelprize.org/uploads/2018/06/bloch-lecture-1.pdf Bloembergen, Nicolas. “Edward M. Purcell (1912-97).” Nature. April 17, 1997. https://www.nature.com/articles/386662a0.pdf Britannica, The Editors of Encyclopaedia. "Isidor Isaac Rabi". Encyclopedia Britannica, 3 Apr. 2024, https://www.britannica.com/biography/Isidor-Isaac-Rabi Britannica, The Editors of Encyclopaedia. 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April 12, 2012. https://doi.org/10.1002/jmri.23642 Prasad, Amit. “The (Amorphous) Anatomy of an Invention: The Case of Magnetic Resonance Imaging (MRI).” Social Studies of Science, vol. 37, no. 4, 2007, pp. 533–60. JSTOR, http://www.jstor.org/stable/25474534 Purcell, E.M. et al. “Resonance Absorption by Nuclear Magnetic Moments in a Solid.” Physics Review. January 1, 1946. https://journals.aps.org/pr/pdf/10.1103/PhysRev.69.37 “Raymond Damadian.” Lemelson-MIT. https://lemelson.mit.edu/award-winners/raymond-damadian Sandomir, Richard. “Raymond Damadian, Creator of the First M.R.I. Scanner, Dies at 86.” New York Times. Aug. 17, 2022. https://www.nytimes.com/2022/08/17/science/raymond-damadian-dead.html Serai, Suraj, PhD, and Tony Dandino. “Why are MRI scans so loud?” Cincinnati Children's Radiology Department Blog. 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