Podcasts about Choline

ai period programs feeding hansen dairy protected postnatal animal science calves animal health university of florida choline phenotype animal nutrition

Play Episode Listen Later Apr 1, 2025 41:00

Dr. Hansen's lab conducted several in vitro experiments where choline chloride was supplemented to beef embryo culture media for the first seven days of embryonic development. Calves resulting from the choline-supplemented embryos were consistently 17-20 kilograms heavier at weaning. In the feeding experiment presented at the Florida Ruminant Nutrition Symposium, Dr. Sagheer fed rumen-protected choline to beef cows one day before AI through seven days post-AI, spanning ovulation, fertilization, and the first seven days of embryo development. In contrast to the in vitro studies, calves born to cows supplemented with choline during the peri-conception period were lighter at weaning than control calves. The panel discusses potential mechanisms of action for these results, including choline's role as a methyl donor potentially impacting the epigenetic programming of the embryo.

Parkinson's, Women, Choline, Dopamine, What do they have in Common?

Keto Naturopath

Play Episode Listen Later Mar 10, 2025 34:27

women parkinson dopamine choline

EP 323 From Nike to Nutrition: A Fertility Journey | Ronit Menashe & Vida Delrahim

Fertility Wellness with The Wholesome Fertility Podcast

Play Episode Listen Later Feb 11, 2025 28:24

On today's episode of The Wholesome Fertility Podcast, Vida Delrahim and Ronit Menashe share their personal journeys from corporate careers to founding WeNatal, a company focused on improving fertility through better prenatal supplements. They discuss the importance of addressing both male and female health in the preconception phase, the science behind their product formulations, and the need for education and resources for couples trying to conceive. Their mission is to empower individuals with knowledge and high-quality supplements to enhance fertility outcomes. Takeaways Ronit and Vida met at Nike and became best friends. Ronit's experience in functional medicine changed their trajectory. Miscarriages led them to explore fertility solutions more deeply. Men contribute to 50% of miscarriages due to sperm quality. WeNatal was created to support both partners in fertility. Their prenatal supplements are designed for bioavailability and effectiveness. They focus on simplifying the supplement process for women. Education is key in supporting couples on their fertility journey. Their blog offers valuable resources for those trying to conceive. They emphasize the importance of quality ingredients in supplements. Guest Bio: Ronit Menashe and Vida Delrahim are the founders of WeNatal, a prenatal supplement company that is transforming the fertility space with the first prenatal supplement optimized for her AND him. WeNatal's mission to change the narrative surrounding fertility and reproductive health is personal; after suffering miscarriages a week apart, Ronit and Vida were given little direction on what to do differently. More importantly, the health of Ronit and Vida's partners(including the health of their sperm) was completely missing from their fertility dialogue with their doctors… something had to change. That is why WeNatal was born, to shift the fertility journey from "me" to "we.” WeNatal is revolutionizing the prenatal space and backed by industry leading Functional Medicine doctors, nutritionists, and fertility experts, including Dr. Mark Hyman and Kelly LeVeque. With 24 key clean, bioavailable nutrients, WeNatal steps up where other supplements fall short for all things preconception to postpartum for both parents and baby. Websites/Links: Free Preconception Guide: WeNatal.com/guide https://www.instagram.com/we_natal/?hl=en For more information about Michelle, visit: www.michelleoravitz.com Check out Michelle's Latest Book: The Way of Fertility! https://www.michelleoravitz.com/thewayoffertility The Wholesome FertilityFacebook group is where you can find free resources and support: https://www.facebook.com/groups/2149554308396504/ Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast for Neat and Vita. Vida Delrahim (00:02) Thanks for having us. We're so excited to be here. Ronit Menashe (00:04) So happy to be here. Michelle (00:06) Yes, so happy to have you guys. And I know that you guys have such an interesting story, first of all, on how you met and also the experience you guys went through together. So without giving anything away, I would love for you guys to share your stories, your personal stories and how that eventually led you to doing your passion project. Vida Delrahim (00:26) Yeah, I'd love to. So it's fun story because we never envisioned to be in the supplement space. And in fact, Ronit and I met in our corporate careers at Nike close to 18 years ago and became best friends and really just kind of embarked in life together. Ronit went on to work in the functional medicine space and we should all thank our lucky stars that she did because it kind of completely changed our trajectory. So. I had a miscarriage right when she was having her first daughter. And of course the answers we were given were very dismissive. They were typically like very common, keep trying, you're lucky you even got pregnant, could be the stress, could be a slew of things. They just kind of shove you along as part of the process. And I didn't know any better, of course, having my first and Ronit was actually in the functional med space, immersed and kind of taught me things like, have you checked your thyroid? Have you done this? Have you done that? Lo and behold, I had Hashimoto's, I didn't even know about it. Just that simple act of fixing my thyroid with medication and visiting an endocrinologist allowed me to have a healthy baby girl. And then fast forward to 2020, I had another miscarriage. And a week after, Ronit had one. And I think this was, it happened a week apart. This was a little bit shocking because... Like I kind of just accepted that this stuff happens, but Ronit working alongside Dr. Mark Hyman, who's very amazing functional practitioner, she was all about the root cause. She was all about the answers and the questions and the answers she was given was very similar, but she wasn't willing to accept that. Like, you know, there's nothing you can do as an answer. Michelle (02:02) Mm-hmm. Ronit Menashe (02:03) And I think for me, Michelle, the reason why it was so shocking was because I was a huge fan of functional medicine for so many years and I already was doing all of the things, or at least I thought I was. I had already cleaned out my house from plastics. I had already, you know, was eating organic food. I was focusing on movement. I was taking pretty good supplements. or at least what I thought was good supplements. And I was shocked. And when I started to dive into the root of what was happening, because it didn't make sense to me that my doctor said, there is nothing you could do to improve your fertility, literally. It is just common, just keep trying. I thought that makes zero sense. And I'm gonna learn about how to improve my egg quality. I thought. Michelle (02:48) Mm hmm. Ronit Menashe (03:01) It was a net quality issue. was 41 at the time. That's what made sense to me. And my biggest aha was when I learned that 50 % of miscarriages happen because of sperm quality. And that was when I called Vida and I said, Vida, did you know that men contribute to 50 % of miscarriages and that 50 that that sperm quality is easily improved using antioxidants like CoQ10 and AC. In fact, studies after studies show that when men take an antioxidant blend in high dose bioavailable forms, they can quadruple their chances of their partner getting pregnant and having a live birth. So, That was our big light bulb moment when we thought like, my God, we need to create a prenatal for men. And we need to scream this from the rooftops that men have a huge role, huge role in improving fertility outcomes and pregnancy outcomes for their families. And that was where we started our journey. Michelle (04:13) It is so important. can't even like tell you. It's so crazy because I have people that go to their doctors and so many times they don't even check the men. And also the DNA fragmentation, which is a whole other thing. Cause like, yeah, you can have perfect sperm numbers and motility and morphology. But if the DNA is off and that can get really impacted by the antioxidants, then that can make a big difference on so many things on IVF, is so expensive too. So I love that you guys bring this up. It's so important. Vida Delrahim (04:50) It's so important and how is it that we're so far in like medicine and women's rights, but like yet the burden of fertility still solely is falling so Ronit and I knew that was like the beginning of our mission that one, women and men deserve better products because we can talk about how once we uncover the fertility and the supplement space, we learn so much, but also that they both need to be leveling up their health. They both need to be part of the conversation. And WeNatal was really born to really level up both partners and bring them together during this journey and give them the best tools and the best nutrition to level up their health in this crucial timeframe, which is preconception. Michelle (05:32) For sure, and we're neat. So you had a different background and you changed your career like me. Ronit Menashe (05:38) Well, my background was in marketing. That's where Vida and I met at Nike. And I fell in love with functional medicine when I got into CrossFit and I learned about the Paleo diet. And then I learned about functional medicine. And then I started to do, you know, become, I became a functional medicine patient myself. And this was a year before, you know, we need years before we natal. And I just fell in love with this idea of medicine of the root cause. And once you learn it, you can't unlearn it. Like that's how you think about everything. It's like, even when, you know, your child has a tantrum nowadays, you're like, okay, like it's not them. Is it there? Is it that they're tired? Is it that they're hungry? Is it that they had sugar? You know, you, you Michelle (06:27) you Bye. Ronit Menashe (06:35) learn about root cause medicine, you realize it, you know, that just everything is connected. And so for me, that was, you know, a big change in my career because I was focused more on marketing. And then I wanted to get into the functional medicine space. I took Chris Kresser's adapt course and, know, kind of started to learn about becoming a practitioner, but it ended up serving me very well when I met Dr. Mark Hyman and I worked on his private practice and worked on his private practice more from like operations. And then I worked with him on his book launches. So still kind of like in the business side of things, marketing side of things, but more focused on this space that I love so much, which is functional integrative medicine. Michelle (07:26) That's amazing. so I'm sure with that background, and also realizing that there is a need for this. It really inspired you to do, to have this supplement company. Ronit Menashe (07:38) 100%. We spoke to Dr. Hyman when we first came up with the idea and he said, I always treat the man when a woman comes to me with infertility. And so what we wanted to do with WeNatal is be able to give everybody access to this kind of functional medicine approach, which essentially means optimizing male fertility and female fertility before trying to conceive. what it looks like is nourishing your body and kind of, creating that optimal soil for conception. And, know, we always say when you improve your health, you're improving your fertility. And when you're improving your fertility, you're improving your health. And we hear from so many customers that, you know, let's say men, for instance, they're taking we natal for him. And all of a sudden they have a libido all of a sudden. They have energy, they focus, their hair is growing. So that's kind of the side effects and the byproduct of working on improving your sperm and egg quality is you actually also feel good when you're nourished. You feel good when you're depleted from nutrients. Of course, you're going to be tired. And so many people just accept this notion of like, I'm getting older so I should be tired or I'm getting older I should be losing my hair or I'm postpartum I should be Michelle (09:06) Like it's normal, normal versus common. Vida Delrahim (09:08) Exactly. Exactly. Ronit Menashe (09:09) Exactly. Exactly. So yes, these things are common, but they're not normal. And Vida and I just, you know, had this like life circumstance where we realized like it's our mission now to educate people on the importance of preconception, that there is so much you could do as a couple. He needs to be part of the equation. And when we started WeNatal, we didn't know if the men would be into it, but we're happy to say Our we-natal men are amazing. We have so many incredible couples that are doing this together from day one. And we're always saying like, they're gonna be the best dads. If they are participating in fertility so early, they are amazing parents already. Michelle (09:56) So yeah, for sure. And talk about like the different ingredients or the and what they do when it comes to both egg and sperm quality. And you can take your time on this Ronit Menashe (10:08) for sure. Well, you know, here's the thing. We didn't think that the world needed another prenatal for women because there are so many prenatals out there, thousands. know, and. But when we started to dive into it and particularly for us, we were taking these packets made out of plastic that had seven pills in them. And we just thought women deserve better. Why do they need to take seven pills? Why do they need to throw out plastic every day? Like we care about creating these healthy little humans. What about the environment? there was that. Then when we looked at the lower level prenatals, we noticed that a lot of the ingredients were not bioavailable. So what does that mean? not everybody could utilize the nutrients that are part of those prenatals. So let's use folic acid as an example. When a prenatal has folic acid, that is the synthetic form of folate, which a lot of prenatals on the market, like if you go to a CVS or a Target, they have folic acid. And if somebody has the MTHFR genetic mutation, They cannot utilize that folic acid. And so that nutrient is actually harmful to them. So for we natal, all of our nutrients are bioavailable. They're all in the methylated B form. like methyl folate or 5MTHF. So first of all, we have bioavailability. Second of all, comprehensiveness. A lot of the prenatals on the market have 12-ish ingredients. We have 24 nutrients and we wouldn't leave one nutrient out. And it's very important because each and every one of our nutrients that are in our prenatal serves a very specific purpose for mom and baby and health of the pregnancy. And then you have... dosages because even if something has 24 key ingredients like we natal the Dosages make a big difference. So using choline as an example choline We natal has 400 milligrams choline is crucial for baby brain development and the research shows that a pregnant woman needs 450 milligrams and a lactating woman needs 550 milligrams the average Choline intake in the American diet, which you get choline from egg yolks is around 180. So we natal has 400 to be able to support that postpartum mom and obviously the pregnant mom, but there are prenatals on the market that have 50 milligrams. Now this is crucial for cognition of baby, brain mass, baby brain development. Michelle (13:15) Mm-hmm. Ronit Menashe (13:22) And so we were like, we have to create a prenatal for us because what we were doing is we were taking that base prenatal. We were adding choline. We were adding vitamin D. We were adding folate. We were adding iron. And most women are not going to do that. Most women are not going to, you know, take 10 plus pills a day and spend all that money on all of these nutrients. We were doing it because we were immersed in the research and we saw how important these nutrients were. But we wanted to create a product that made it simple and easy for women and men to take their prenatal. Our packaging is beautiful and the reason is, well, first of all, we love nice things, but also, Michelle (14:15) Thank Ronit Menashe (14:16) We wanted it to be part of people's home, people's life. So they're not hiding their prenatals in their, you know, cabinets that they can take it every day because consistency, like everything in health and wellness, consistency is what's going to make the biggest difference. And so that's kind of from a high level. And then, you know, you asked me what's in the prenatal and we can geek out a little bit more on the nutrients and what they do. But what's not in the prenatal is also a big, big key because a lot of supplements on the market have a ton of additional ingredients and those ingredients are harmful for fertility and just overall health. And so it's important. We always say it's important to look at the nutrition facts. but also look underneath the nutrition facts like what else is in there that shouldn't be in there and we natal doesn't have any additional fillers. And we do that because we manufacture in smaller dosages. We're not manufacturing in mass. Our shelf life is only two years where it's not like some prenatals that their shelf life is forever. which, you know, for us, we're fine. We're doing things in smaller batches. And, you know, from a business perspective, it complicates things, definitely complicates Vida's life because she's on the operation side of things, but we're doing the right thing for the consumer. And that's what matters to us the most. Michelle (15:43) . So I know that like for my patients, for example, I'll give them certain supplements, preparing, including a prenatal, but then I'll also add more supplements that I don't necessarily have them continue taking after they're pregnant. So some that are more like to beef up the quality of the eggs. Do you guys have different ones or is it like certain? Yeah. Vida Delrahim (16:13) Mm-hmm. Ronit Menashe (16:16) Yes. Yes. So we have our foundation support, which is the prenatal for him and for her. That is the multivitamin for men slash sperm support. And for women, it's the prenatal that has key nutrients for before, during, and after. But for those who want to beef up their egg quality, and we could talk about the scenarios in which you would need this product or not. Michelle (16:35) Mm-hmm. Ronit Menashe (16:44) We have a product that we launched this year called Egg Quality Plus, and it's five nutrients in one. So it's the five nutrients that we were taking after our miscarriage, CoQ10, NAC, PQQ, alpha lipoic acid, and L-carnitine. And what these nutrients do is they help improve egg quality. How do they do it? Michelle (16:49) Mm-hmm. Mm-hmm. Ronit Menashe (17:12) These nutrients are very specific nutrients that help improve mitochondria. We know that the three months before you ovulate, the egg that you ovulate with is going through all these processes that are very complex that require very strong mitochondria. So your mitochondria is like the battery of the cell. And if the battery is low, that process is not gonna go well and you're gonna end up with chromosomal abnormalities. So it's important to quote unquote charge the battery before you start trying so that when that process does take place, it happens with no or limited errors, if that makes sense. So we recommend for women who are either older or maybe had recurrent miscarriages or Michelle (18:00) Yeah. Ronit Menashe (18:09) Just wanna know that they did everything possible in the preconception timeframe to take Egg Quality Plus with our prenatal, which the prenatal also includes nutrients that help improve egg quality like folate, vitamin D. By the way, 4,000 I use a vitamin D. I don't think any prenatals on the market have that. And then, you you talked about in the postpartum phase, like for us, what was very important to include in our prenatal is iron because in the postpartum phase and in third trimester, a lot of women are very depleted from nutrients because you require more iron in that timeframe and just to help with postpartum recovery and all of those things. So our prenatal has iron in it as well. So what we wanted to do with the prenatal is be able to simplify people's lives and give them a tool that they can use before, during, and after. Then if somebody wants that extra boost, they could get that Egg Quality Plus B4. And that's kind of the philosophy. We wanna make it simple and easy. And the other thing that I didn't mention is our prenatal dosage is three pills a day. And so... Michelle (19:13) Mm-hmm. Mm-hmm. Mm Ronit Menashe (19:31) We just don't think it's realistic to ask women to take eight pills plus per day for their prenatal, especially in their first trimester when they're nauseous and they're throwing up and they can barely stomach any food. Michelle (19:41) Yep. yeah, for sure. And then as far as the iron, I know there's many different forms of iron and some can cause constipation. So I just wanted to ask about that. Ronit Menashe (19:53) Yeah, so the forms, we didn't get into the like real geekiness of our forms, but every single one of our forms are the best form that we can find. And we use a patented iron that doesn't constipate called ferrochell. And we do the same with some of our other ingredients, like our choline is microencapsulated. Every, our selenium is this like super special selenium. Every single one of our nutrients is sourced from the best of the best because we feel like women deserve the best. This is such an important time in people's lives and the nutrients really make a big difference and can make or break your journey. Michelle (20:43) I love that. I love that you're really putting attention to detail because it does make such a difference. And the thing is the thing, the reason why I'm asking also is just from my perspective as a practitioner, I'm always looking for supplements that can address so many issues. And what I find myself doing is getting a bunch of different things and then having to give so many different supplements and so many different bottles. So I love the fact that you guys have this really like thought out. It's really nice. Vida Delrahim (21:16) Well, that's essentially what Ronit was doing with me when we were on this journey together. She was AKA my doctor. And she's like, look at all the research shows that you need add iron you add this and so it ended up being I don't know Roni at some point I swear it was like 1215 maybe capsules because of all the additions some of it was drops. I could not keep up Ronit was a champion at taking supplements she could like down 10 at a time. I was nursing a couple meal Michelle (21:41) Yeah. Vida Delrahim (21:43) And of course I wouldn't even comply. And so that was when also the idea of we need to like the ease and simplicity is so important. We're all busy, but we want to know that we're giving our body the best nutrients. I had guilt about not taking enough because I literally just couldn't down pills as quickly as some people can. And so the fact that we're able to get these 24 quality bioavailable ingredients into three capsules took us years. And we're so proud of that because it is the nutrient density of six to eight capsules in three. And so that's what we were doing. We realized it wasn't feasible for everybody. Not everyone is at a road who can just chug them along. We realized this world had to be reinvented. Michelle (22:23) yeah, for sure. Well, this is great. mean, lots of great information. I'm looking at your website right now, actually. Yeah, you guys definitely, it looks like you guys did a lot of research and you also have a blog, which is great. Cause I think it's so important to educate people that are on this journey. Ronit Menashe (22:44) Well, that is exactly what we didn't have. It's so hard to reliable information that you can trust. And so we have an amazing blog and we put out so much great content on literally any topic under the sun from what to do if you just got diagnosed with gestational diabetes to, okay, how do you create a clean nursery to you know how to you know the fertility crisis you know we span everything on the blog and we share about it in our newsletter and we have an amazing guide with nine preconception tips if your listeners want to go to we natal.com slash guide they get our free couples guide and it's a really great starting point and a lot of the things that couples could do to support their fertility is free it doesn't have to be like complicated or fancy. It's a lot of like free things. And so that guide is a really great resource. Michelle (23:50) Awesome. Well, this is great information and you guys, this isn't a sponsored episode. It really is me wanting to find out more because there are amazing new things out there. And I think that it's important to hear all the different perspectives and really get it from the founders. So thank you guys so much for coming on and for people who are looking to learn more, how can they find you guys? Ronit Menashe (24:19) They on we natal.com our website on social. We're very active and that's where we also share a lot of the new research at we underscore natal. And also we're happy to hear from your listeners. Anybody has questions or needs help or needs us to point them in the direction of some something or some article they can DM us at our, on our Instagram where we're most active. Michelle (24:49) Awesome. Well, I loved this conversation and I loved all the details and the nerdy aspects of it because for me, I really liked the breakdown. think one thing that I find is that you want to find the smartest audience. It's usually a fertility audience. They're so smart because they do so much research on their own health and they really look into much more than the doctors give them. so, So I know that they like to find out really detailed information. So thank you for that. And thank you so much for coming on today. Vida Delrahim (25:26) Thanks for having us. We're excited to support you and your community. Michelle (25:31) Awesome. Ronit Menashe (25:31) Thanks, Michelle.

Glyphosate, Choline & Alzheimer's: Toxins & Nutrition to Prevent Neurodegeneration | Ramon Velazquez | 208

Mind & Matter

Play Episode Listen Later Feb 8, 2025 42:39

Send us a textShort Summary: The complexities of neurodegenerative disease, particularly Alzheimer's, environmental influences like glyphosate, and the crucial role of nutrients like choline, with actionable insights into brain health management.About the guest: Dr. Ramon Valazquez is an Assistant Professor at Arizona State University, leading a research lab at the Neurodegenerative Disease Research Center. His work focuses on environmental factors related to Alzheimer's and other dementias, alongside developing therapeutic strategies.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and to everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Dr. Ramon Velazquez explores neurodegenerative disease, with a deep dive into Alzheimer's, its pathophysiology including amyloid beta plaques and tau pathology. It examines the controversy around these proteins' roles in disease progression, the influence of environmental toxins like glyphosate on brain health, and the preventive potential of nutritional interventions, particularly choline.Key Takeaways:Neurodegenerative Disease Basics: Alzheimer's disease involves both amyloid beta plaques and tau tangles, with tau pathology more closely linked to clinical symptoms.Environmental Impact: Glyphosate, a common herbicide, can cross into the brain, potentially exacerbating neurodegenerative pathways through inflammation.Choline: Essential for brain function and fat metabolism, it's often deficient in diets, particularly plant-based ones. Adequate intake might prevent or mitigate cognitive decline and related diseases.Preventive Measures: Early nutritional intervention, like maintaining choline levels, could be vital for preventing neurodegenerative diseases. However, once symptoms are present, such interventions might not reverse existing pathology.Related episode:M&M #145: Epigenetics, HormonesSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Use your phone's link. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

What Every Parent Should Know Before Having Their Kid (Or Themselves) Take a Genetic Test with Dr. Erika Gray

The Wellness Mama Podcast

Play Episode Listen Later Feb 4, 2025 31:56

Episode Highlights with Dr. Erika GrayUnderstanding privacy concerns with genetic testing, especially in light of the security breach with a major DNA company recently Samples sent to testing companies are de-identified and not connected to personal dataSecurity concerns and how to make sure yours is safeHow their specific testing has layers of encryption and is not even mined for dataYou can use an alias on your genetic testing The limits of genetic testing and what it can and can't tell us Genetics is a screening tool and not a diagnostic tool — related to cancer risk and expressionMore related to choline and how this can be really beneficial for focus and attention Resources We MentionMy Toolbox Genomics - Use code wellnessmama for a discount

dna parent genetic data security cancer risk privacy concerns choline

199. [Doula Talk] Nutrition Boost

Entering Motherhood

Play Episode Listen Later Feb 4, 2025 17:55 Transcription Available

Welcome to The Entering Motherhood Podcast. In this special Doula Talk session, host Sarah Marie Bilger is joined by Katelyn, co-creator of the O.W.N. Your Birth Childbirth Education course, to delve into the vital topic of nutrition. For those navigating the journey of conceiving, pregnancy, or postpartum, this episode is packed with actionable insights aimed at empowering you. From exploring the significance of protein, fats, and carbohydrates to discussing essential vitamins like Vitamin D, Choline, and Iron, we're here to support your motherly path. Tune in as we unravel nutrition myths, provide tips for meal prepping, and share personal experiences that highlight the flexibility and personalized approach one can take towards diet during motherhood. Whether you're contemplating risk vs. benefits with foods like sushi and caffeine or just need guidance on forming healthy habits before entering pregnancy, this episode is a treasure trove of wisdom and encouragement. We'll also discuss cultivating a routine that works harmoniously with the lifestyle you aspire to achieve. Engage with us, share your nutritional challenges, and join a community that's dedicated to empowering you in your unique motherhood journey. Let's doula this, together. Click here for full show notes

nutrition boost engage vitamin d doula choline

Ep 539: Midlife Metabolism: Weight Gain and Fatty Liver Over 40 with Dr. Jannine Krause

The Health Fix

Play Episode Listen Later Feb 1, 2025 18:33

Gas, bloating, brain fog, depression and anxiety are symptoms conneted to aging as well as perimenopause and beyond. These symptoms are often misdiagnosed and overlooked as a cause of fatty liver. The good news is you can identify fatty liver before it damages your liver. In this episode of The Health Fix Podcast I share a connection I'm seeing with to stubborn weight loss and weight gain over 40. What You'll Learn In This Episode: Surprising symptoms of a fatty liver that mimic hormone imbalances How to use basic labs your doctor runs on you to see if you have a fatty liver What nutrient deficiencies are related to fatty liver How to adjust your diet and nutrients for a fatty liver Resources From The Show: Hepatic steatosis Index Fatty liver Index List of nutrient deficiencies related to a fatty liver: 2-4 weeks Very low carb and fat diet Hypochloric low carb or mediterranean diet thereafter Cardio and resistance exercise Vit E + Tocotrienols Choline N-Acetyl Cysteine Omega3's Carnitine Berberine Milk thistle Nigella seed Hesperidin Probiotic

anxiety depression milk weight loss surprising gas menopause midlife metabolism cardio weight gain probiotics perimenopause bloating hormone imbalance fatty liver nigella choline jannine krause

Methyl Donor Nutrition in the Transition Dairy Cow with Dr. Joe McFadden, Cornell University

Play Episode Listen Later Jan 21, 2025 44:53

This Real Science Exchange podcast episode was recorded during a webinar from Balchem's Real Science Lecture Series. You can find it at balchem.com/realscience.Feeding rumen-protected choline in early lactation has consistently increased milk yield and energy-corrected milk yield, which is more pronounced when cows are fed diets low in metabolizable methionine. Choline feeding also increases milk fat and protein yield, minimizes body condition loss in early lactation, and reduces postpartum disease incidence. Dr. McFadden presents three topics about choline biology in the dairy cow. (01:45)Why should we consider fatty acid feeding when feeding methyl donors like choline and methionine?Choline degradation in the rumen and small intestine, focusing on the role of triethylamine oxide Why should we consider lysophosphatidylcholine as an immunomodulator in fresh cows and preweaning calves?Fatty acid nutrition to optimize methyl donor efficiency. (4:02)Fatty liver is a concern for fresh cows because of its relationship with ketosis, poor fertility and compromised milk production. Cows with fatty liver exhibit low circulating concentrations of phosphatidylcholine, which is a component of very low-density lipoproteins (VLDL) that transport triglycerides out of the liver. Feeding rumen-protected choline lowers liver triglyceride deposition by supporting the synthesis of phosphatidylcholine and thus, VLDL. Dr. McFadden goes on to explain the two different pathways for phosphatidylcholine in the liver and how those interact with fatty acid metabolism. He describes several experiments that have investigated how rumen-protected choline and supplemental fatty acids interact in lactating cows. Low phosphatidylcholine supply is a key feature of fatty liver in dairy cows, likely due to low polyunsaturated fatty acid (PUFA) and low choline supplies. Delivery of post-ruminal PUFA may support phosphatidylcholine synthesis with accompanying improvements in insulin sensitivity, body condition maintenance, and inflammation, but interactions with dietary fatty acid digestibility should be considered. Dr. McFadden gives a list of considerations for fresh cow diets incorporating fat and choline supplementation. Gastrointestinal choline degradation and trimethylamine N-oxide (TMAO) (16:58)Unprotected choline is almost totally degraded in the rumen. Microbes convert choline into trimethylamine (TMA) which is then converted to TMAO in the liver. Rumen-protected choline allows for a large proportion of choline to reach the small intestine intact. However, research shows that choline can also be degraded by microbes in the small intestine in the same pathway, limiting choline bioavailability. Plasma TMAO accumulation is associated with non-alcoholic fatty liver disease, inflammation, insulin resistance, obesity, oxidative stress, and cardiovascular disease in rodent and human models. Little research was available regarding if the relationship between TMAO and poor health was causative or just associative. Dr. McFadden's lab infused cows intravenously with TMAO and found that TMAO did not modify milk production or glucose tolerance in early lactation cows. TMAO does not appear to influence energy metabolism or health in early lactation cows. Choline is subject to both ruminal and lower-gut degradation to TMA, and that influence on choline bioavailability needs to be defined. Data in non-ruminants suggests that unsaturated fatty acid feeding can shift the gut microbes to slow TMA formation. Lysophosphatidylcholine and immunomodulation (28:45)Dr. McFadden gives an overview of neutrophil activation and the oxidative burst that contributes to pathogen killing. The ability to elicit the oxidative burst is diminished in pre-weaned calves and transition cows. When cows were given endotoxin to cause an immune response, circulating lysophosphatidylcholine was decreased. In rodent models, lysophosphatidylcholine promotes the oxidative burst and suppresses long-term inflammation in response to bacterial infection. Dr. McFadden cultured neutrophils from pre-weaned calves with lysophosphatidylcholine and observed an enhanced oxidative burst.Immunosuppression is characterized by low circulating lysophosphatidylcholine concentrations in dairy cows. In vitro data suggests lysophosphatidylcholine can activate neutrophils, and rumen-protected choline increases circulating lysophosphatidylcholine. Future research is likely to define an immunomodulatory role for choline. Dr. McFadden takes questions from the webinar audience. (38:07)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Lecithin VS Choline Part 2

molecular metabolic fig choline betaine lecithin

Play Episode Listen Later Jan 21, 2025 9:45

This is the second of a 2 part response to a question about lecithin vs choline. Here's the link to part 1. https://open.spotify.com/episode/2at2pXZQ02Wt9ZmYq3lczz?si=6exmen2-QjWM2fJ6aaItog Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Information References: https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116 https://lpi.oregonstate.edu/mic/other-nutrients/choline https://pubmed.ncbi.nlm.nih.gov/14938439/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/ https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/ Image References: https://cordancemedical.com/the-problem/blood-brain-barrier/ https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691 https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357 https://www.ncbi.nlm.nih.gov/books/NBK114308/ https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5 https://www.ncbi.nlm.nih.gov/books/NBK594255/ https://pubchem.ncbi.nlm.nih.gov/compound/Choline https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid https://www.mdpi.com/2072-6651/8/11/326 https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/ https://www.examine.com/supplements/alpha-gpc/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/ https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/ https://lpi.oregonstate.edu/mic/other-nutrients/choline https://www.researchgate.net/figure/molecular-structure-of-the-phosphatidylethanolamine-eluting-at-462-min_fig2_23771336 https://www.nature.com/articles/srep16787 https://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065 https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1109445/full https://ncbi.nlm.nih.gov/books/NBK554408/ https://www.researchgate.net/figure/A-simplified-illustration-of-the-homocysteine-metabolism-pathway-BHMT-betaine_fig1_341362341 https://www.researchgate.net/figure/Fig-2-The-nucleus-basalis-of-Meynert-innervates-the-entire-cerebral-mantle-with_fig1_327756974 https://www.researchgate.net/figure/The-human-cholinergic-system-Cholinergic-nuclei-are-primarily-located-in-numbered-cell_fig1_345346799

Lecithin VS Choline Part 1

molecular metabolic fig choline betaine lecithin

Play Episode Listen Later Jan 19, 2025 7:48

This is the first of a two part response to a question about lecithin vs choline. Stay tuned for part 2. Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Information References: https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116 https://lpi.oregonstate.edu/mic/other-nutrients/choline https://pubmed.ncbi.nlm.nih.gov/14938439/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/ https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/ Image Resources: https://cordancemedical.com/the-problem/blood-brain-barrier/ https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691 https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357 https://www.ncbi.nlm.nih.gov/books/NBK114308/ https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5 https://www.ncbi.nlm.nih.gov/books/NBK594255/ https://pubchem.ncbi.nlm.nih.gov/compound/Choline https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid https://www.mdpi.com/2072-6651/8/11/326 https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/ https://www.examine.com/supplements/alpha-gpc/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/ https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/ https://lpi.oregonstate.edu/mic/other-nutrients/choline https://www.researchgate.net/figure/molecular-structure-of-the-phosphatidylethanolamine-eluting-at-462-min_fig2_23771336 https://www.nature.com/articles/srep16787 https://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065 https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1109445/full https://ncbi.nlm.nih.gov/books/NBK554408/ https://www.researchgate.net/figure/A-simplified-illustration-of-the-homocysteine-metabolism-pathway-BHMT-betaine_fig1_341362341 https://www.researchgate.net/figure/Fig-2-The-nucleus-basalis-of-Meynert-innervates-the-entire-cerebral-mantle-with_fig1_327756974 https://www.researchgate.net/figure/The-human-cholinergic-system-Cholinergic-nuclei-are-primarily-located-in-numbered-cell_fig1_345346799

ENCORE: Q&A with Leyla, Part 2: The Choline in Eggs

Intelligent Medicine

Play Episode Listen Later Jan 16, 2025 29:53

What dosage of Nicotinamide Riboside is optimal in increasing mitochondrial biogenesis?I've been treated for SIBO in the past but haven't yet tried rifaximin. Do you recommend it?Is the choline in eggs causing thousands of people to suddenly form blood clots?Is the EBCT still the most accurate, least-radiation-exposure test for coronary calcification?How many milligrams of SAMe do you recommend for depression?

Antihistamines And Choline

answering choline antihistamines

Play Episode Listen Later Dec 25, 2024 6:59

Answering a question regarding antihistamines and the effects on acetylcholine receptors. Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Resources: https://www.jacionline.org/article/S0091-6749(06)02977-0/fulltext https://www.ncbi.nlm.nih.gov/books/NBK557790/ https://www.ncbi.nlm.nih.gov/books/NBK538188/ https://pubmed.ncbi.nlm.nih.gov/11164999/ https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14696 https://www.ncbi.nlm.nih.gov/books/NBK526010/ Image Resources: https://www.ebiohippo.com/en/aav-actone-gpcr-assay-kits.html https://www.science.org/doi/10.1126/science.aaw5188 https://meducatmedical.com/what-is-continence/

Stop Doing This If You Have Low AMH/High FSH (Top Time Wasters)

Play Episode Listen Later Dec 16, 2024 52:08

We're digging into how to improve pregnancy success in 2025 when you have low AMH and/or high FSH. Focusing on the AMH biomarker wastes time. After all, it's used to see how well you'll do with IVF. It doesn't predict your ability to get pregnant naturally, measure egg quality, or check your uterine receptivity. The bottom line is that it's extremely triggering and scares women into rushing to IVF or thinking donor eggs are the only option. We've helped couples with an AMH of 0.02 ng/mL at the age of 44 get pregnant naturally after they were told donor eggs were the only next step. So, what are the next steps for low AMH, and how can we get pregnant in 2025? In this episode, you'll learn: 1) Why AMH is not useful to determine why you are struggling to conceive 2) The final word on HRT and what you need to consider (especially if you're dealing with certain symptoms) 3) Cutting-edge functional lab testing that can get to the bottom of why it's not working 4) The final word on PRP (platelet-rich plasma) ovarian rejuvenation and when/if to start this 5) How to improve egg quality and get pregnant with low AMH and/or high FSH --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

focusing cutting ivf ultimate guide ml hrt prp ttc timewasters folate amh fsh sarah clark choline

How To Improve Erectile Dysfunction Naturally and Get Pregnant with Dr. Anne Truong

united states mistakes testing naturally ultimate guide supplement viagra erectile dysfunction ttc get pregnant erectile folate amh sarah clark choline anne truong

Play Episode Listen Later Dec 9, 2024 49:17

We're digging into how to address erectile dysfunction during the fertility journey. Erectile dysfunction (ED) impacts over 30 million men in the United States. Beyond the impact on intimacy, it also is a barometer of a man's overall health. It's not a normal part of aging but rather a sign to dig deeper to address underlying health issues. When you're on the fertility journey, ED can reduce the frequency of sex, often making it difficult to coincide with the fertile window. And while medications such as Viagra can help manage the symptoms of ED, it does not address why it's happening in the first place. While ED doesn't necessarily mean there's a problem with sperm health, the health of the male partner is essential when you are TTC (it's not just about focusing on egg health). So, how do we address ED naturally and improve the chances of pregnancy success? I'm excited to welcome Dr. Anne Truong to the podcast. Dr Anne has 25+ years of experience in anti-aging and cellular medicine. She is an expert in intimate health and a leader in biologic regenerative medicine. In this episode, you'll learn about: 1) Mistakes that can make ED worse 2) Reasons for low libido and the role of gut health 3) Testing to consider (i.e. cardiovascular, adrenals, hormones) 4) Supplement and diet/lifestyle recommendations --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

The Dual Essentiality of Choline and Methionine with Dr. Heather White, University of Wisconsin-Madison

Play Episode Listen Later Dec 3, 2024 45:53

This Real Science Exchange episode was recorded during a webinar, which was part of a series. Watch all the presentations from this series here: https://balchem.com/animal-nutrition-health/resources-categories/real-science-lecture-series/previous-lectures/page/10/Early in lactation, the cow is incapable of eating enough to meet her dramatically increased requirements. As the cow's intake decreases near calving, there are fewer nutrient contributions from dry matter intake and she must alter nutrient partitioning to meet her increased needs by mobilizing fat and muscle stores. (1:18)Triglycerides from fat stores are broken down into non-esterified fatty acids (NEFA) and glycerol. NEFA has two different fates in the postpartum cow: to the mammary gland as a precursor for milk fat synthesis, or to the liver to be oxidized for energy production. Glycerol enters the gluconeogenic pathway in the liver as a glucose precursor. (4:41)The capacity for the liver to use NEFA for energy is limited by the capacity of the TCA cycle. When the TCA cycle is at capacity, excess NEFA can either undergo incomplete oxidation to ketones or be repackaged back into triglycerides. If the capacity for other tissues to use ketones for energy is exceeded, then blood concentrations of ketones rise and negative outcomes from subclinical and clinical ketosis can occur. If triglycerides accumulate in the liver, negative outcomes associated with fatty liver can occur. Triglycerides can be transported out of the liver via very low-density lipoprotein (VLDL) export; however, VLDL export does not keep up with triglyceride concentration during the transition period in dairy cows, largely because of a limiting amount of phosphatidylcholine. (5:51)Dr. White describes a series of experiments in her lab using liver cells in culture to investigate the relationship between choline supplementation and VLDL export. As choline supplementation to the cell culture increased, so did VLDL export from the cells into the media. In addition, increasing choline supplementation to the cell culture also decreased cellular triglyceride content. (10:54)Using gene expression and radiolabeled tracers over a series of experiments, Dr. White's group found that as choline supplementation increased, so did complete oxidation of NEFA to energy. This was accompanied by decreased incomplete oxidation to ketone bodies and decreased accumulation of lipids in the liver cells. Glucose and glycogen were also increased with increasing choline supplementation to the cell culture, and a decrease in reactive oxygen species was observed. In addition, choline-supplemented cultures exhibited an increase in metabolic pathways associated with methionine regeneration and methyl donation. (15:29)Dr. White then details the complexity of the metabolic pathways that intersect between choline and methionine. In similar experiments supplementing cell cultures with increasing amounts of methionine and choline, there were no effects of methionine on lipid export, oxidative pathways, or glucose metabolism. The main benefit of methionine was a marked increase in glutathione production. It's important to note that no interactions between choline and methionine were observed in this series of experiments. (19:37)There seems to be a clear biological priority for different sets of pathways for choline and methionine. Choline seems to be influencing lipid, glucose, and oxidative pathways, while methionine is primarily serving its role as an essential amino acid for cellular protein structure and generation, acting as a methyl donor, and impacting inflammation. Importantly, both the choline and methionine results observed in cell culture are paralleled in transition dairy cow studies. (24:14)Dr. White's lab further investigated the impact of methionine on inflammation. When cells were challenged with LPS to provoke an inflammatory response, methionine mitigated the inflammatory response. Similar results have been observed in liver tissue samples of transition cows. Methionine mitigated inflammatory markers and increased glutathione but did not influence reactive oxygen species. Conversely, choline decreased reactive oxygen species but did not change glutathione. (27:47)Choline and methionine are both essential nutrients, there are biological priorities for them as methyl donors, and they are not mutually exchangeable. The lack of interaction between choline and methionine in vivo or in vitro supports the idea of different biological roles for these nutrients. (32:09)Dr. White takes questions from the webinar audience. (34:53)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

How To Prevent and Reverse Autoimmune Disease and Get Pregnant

The School of Doza Podcast

Play Episode Listen Later Dec 2, 2024 52:20

We're digging into how to get pregnant with an autoimmune disease. A theme we see with low AMH, high FSH, diminished ovarian reserve, or premature ovarian insufficiency is autoimmune disease (i.e., Hashimoto's Thyroiditis, Celiac, Rheumatoid Arthritis, Multiple Sclerosis, Lupus, Psoriasis, Type 1 Diabetes, Chron's, Pernicious Anemia, and way more). There are over 80 different autoimmune diseases, with the prevalence increasing more than 3-12% per year. In the United States, Type 1 Diabetes has doubled in the last 40 years, celiac disease has increased fivefold in the last 30 years, and multiple sclerosis has increased by 30% since 2013. In 1/5 of premature ovarian insufficiency cases, there is an autoimmune disease present, which is often overlooked as a factor with conventional medicine. It's not about taking more medication to manage the autoimmune disease and pushing your body to conceive with IVF. This can lead to cancelled cycles, poor response to medication, abnormally tested embryos, and implantation failure. So, how do we prevent and reverse autoimmune disease so that you can get pregnant in 2025? In this episode, you'll learn: 1) Conventional versus functional medicine approach to treating autoimmune disease 2) Factors that influence autoimmune diseases and what you can do to reverse autoimmune disease 3) Biomarkers to ask your doctor to check that help address underlying factors 4) Diet, lifestyle, and supplement recommendations to address autoimmunity and get pregnant in 2025 --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii Get your free copy of our Autumn Fertility Recipe Guide (includes 5-day meal plan/grocery shopping list, all free from the TOP allergens) at https://www.fertilitydietfreebie.com/. --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

WHAT to Eat on THANKSGIVING for a HEALTHIER Holiday

Play Episode Listen Later Nov 25, 2024 37:20

Holiday Weight Management Guide

thanksgiving holiday tips simple healthy wrap black friday recipes eat differences eggs healthier gut health health benefits yam choline deviled special offer get turkey turkey

How To Navigate The Holidays If You Have Diminished Ovarian Reserve/Premature Ovarian Insufficiency

holidays navigate visiting reserve ultimate guide premature ttc ovarian diminished insufficiency folate amh fsh sarah clark choline

Play Episode Listen Later Nov 25, 2024 37:48

In this episode, we dig into how to navigate the holiday season with low AMH/high FSH. The fertility journey can be all-encompassing, and the holiday season can be challenging. The pressure of the season may have you feeling overwhelmed or burnt out. Visiting friends and family and seeing coworkers who ask that intrusive and annoying question, “Do you have kids yet?” So many of us have been on the TTC journey for years. The stress can start to sneak up on you, impacting your biochemistry. As I've shared before, maybe the low AMH/high FSH is not a sign of menopause; maybe it's that your adrenals are struggling. So, what can we do about it? This episode is for you if: 1) You're constantly getting asked by family and friends when you will have your baby 2) You're not sure what to do for 2025 to optimize your fertility 3) You need an action plan so that you can tell people to mind their own business 4) You wonder if low AMH/high FSH is menopause or whether your doctor is missing an underlying healing opportunity --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii Get your free copy of our Autumn Fertility Recipe Guide (includes 5-day meal plan/grocery shopping list, all free from the TOP allergens) at https://www.fertilitydietfreebie.com/. --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

130: Midlife Strong's Maryann Jacobsen on the intersection of menopause and everything else

The Hotflash Inc podcast

Play Episode Listen Later Nov 23, 2024 43:05

Send us a textMaryann Jacobsen is a registered dietitian with a master's degree in nutrition. She has extensive experience with developmental stages, researching health topics, and writing. She's also a forward-thinker who realizes that when it comes to aging, midlife doesn't get nearly the attention it needs – and for the past five years, she's been working to change that.Maryann has a common-sense, independent thinking approach; she dives deep into research to uncover innovative and original insights. I feel like she's my soul sister when it comes to these things, and the way the narrative is being crafted around perimenopause and menopause, in particular. Her goal is for every woman to have the basic knowledge she needs to make informed health decisions. We cover a lot of ground here: including the role of hormones, the significance of micronutrients like iron and choline, nitric oxide's impact on health, and the necessity of a holistic approach to manage symptoms. The episode also sheds light on how lifestyle changes can enhance the effectiveness of hormone therapy and addresses commonly overlooked issues such as sleep-disordered breathing and its impact on health during midlife.Topics covered: Why it's not as simple as “eat right and exercise” in midlife The risks of drinking while taking hormone therapy (that no one is talking about) All the things that are more interesting than hormone therapy Resistance breathing for reducing inflammation and other benefits The overlooked (and vital role) of nitric oxide All the ways to increase your nitric oxideHormone therapy, sure, but have you heard about beets? Pycnogenol Nasal breathing, headaches and sleep apnea The mixed results of hormone therapy Sunlight The nuances of post-menopause estrogen productionWhy we both are reticent about going estrogen Why beets aren't much help for vaginasWhere to find Maryann and Midlife Strong:Substack: Midlife Strong Instagram: Midlife StrongJoin the Hotflash Inc perimenoposse: Web: hotflashinc.comTikTok: @hotflashincInstagram: @hotflashincX: @hotflashinc Episode website: Hotflashinc See hotflashinc.com/privacy-policy for privacy information

web resistance intersection menopause midlife perimenopause everything else estrogen jacobsen hormone therapy nitric oxide nasal breathing choline hotflash inc

How To Improve Egg Quality When You Have POI/DOR

ultimate guide ttc folate amh fsh sarah clark choline

Play Episode Listen Later Nov 18, 2024 44:28

We're digging into how to improve egg quality if you have premature ovarian insufficiency or diminished ovarian reserve. When you have premature ovarian insufficiency or diminished ovarian reserve, you may have been told you have poor egg quality. This may have you scouring the internet, following egg-quality diets and taking a boatload of supplements. Before you start another diet or take one more supplement, let's uncover the factors that negatively influence your egg health so you can improve your pregnancy success. In this episode, you'll learn: 1) Why your doctor is testing the wrong biomarkers for egg quality 2) The specific diet that helps egg quality 3) How to know if this hormone is impacting egg quality (especially if you have low AMH and/or high FSH) 4) The supplements for egg health (and how not to waste money on supplements) --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

W 11.13.24 Humpday Health! Avoiding a Pacemaker for $10?

The Mike Madison Show

Play Episode Listen Later Nov 15, 2024 43:10

All our "access to healthcare" is not helping us. Access to HEALTH is a much better way. Choline and genius babies. Omega 3s and inflammation. And magnesium helps man avoid a pacemaker?

health omega hump day pacemakers choline

How Low-Grade Inflammation Can Disrupt Hormones and Interfere With Embryo Implantation with Kellie Lupsha

energy hormones grade supplements ultimate guide simple steps inflammation disrupt regain embryos ttc interfere folate implantation amh sarah clark choline free mini course get pregnant naturally

Play Episode Listen Later Nov 4, 2024 49:34

We're digging into how to reduce inflammation to get pregnant. I've been recording the Get Pregnant Naturally podcast for over 6 1/2 years. Everything we talk about on the podcast is designed to reduce inflammation in the body and improve pregnancy success. This episode gives us the foundational steps you can take right now to reduce inflammation that can disrupt hormones and interfere with ovulation and implantation. Today, I'm welcoming Kellie Lupsha to the podcast. Kellie has almost 30 years of experience in the healthcare and wellness field, first as a physical therapist, then as a longevity expert and high-performance health coach, and a lifetime of personal practice in the wellness space. In this episode, you'll learn: 1) The difference between acute and chronic inflammation and why this matters for fertility 2) Steps to take right now to reduce inflammation and get pregnant 3) Supplements to reduce inflammation and the top tip to help your body heal and fight inflammation Kellie Lupsha's FREE Mini-Course: 3 Simple Steps to Regain your Energy: https://bit.ly/simple-steps3 --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

How to DETOX Like a Pro! Phosphatidylcholine, Tudca, and Butyrate for Maximum Cellular Cleansing : 1216

The Human Upgrade with Dave Asprey

Play Episode Listen Later Oct 25, 2024 64:29

Unlock the secret to cellular detox and discover how to cleanse your body from the inside out with Dave Asprey and Jessica Berman in this episode of The Human Upgrade. Explore cutting-edge detox strategies using phosphatidylcholine, Tudca, and butyrate, three powerful molecules designed to remove toxins, microplastics, and endocrine disruptors from your system. Jessica, co-owner of BodyBio, reveals how these products support not just detoxification, but also optimize mitochondrial function, enhance brain performance, and improve overall cellular health. From phosphatidylcholine's ability to restore cell membranes to Tudca's role in liver health, you'll learn how to protect yourself from the daily onslaught of environmental toxins that can harm your longevity and vitality. If you've been searching for how to reduce your toxic load, flush out microplastics, or boost cognitive function, this episode is packed with actionable insights. Whether you're a biohacker looking to enhance your cellular resilience or someone curious about how these supplements can improve your overall health, this episode will take your detox game to the next level. Get ready to learn how to detox like a pro, rebuild your cell membranes, and optimize your brain and body with these game-changing biohacks! Resources: • BodyBio Phosphatidylcholine, Tudca, Butyrate & More – Get 25% off BodyBio products with code DAVEASPREY https://bodybio.com/dave • Dave Asprey's Website – https://daveasprey.com • The Human Upgrade Podcast – https://daveasprey.com/category/podcasts/ • Danger Coffee – https://dangercoffee.com • Danger Coffee Instagram – https://www.instagram.com/dangercoffeeofficial/ • Dave Asprey's Linktree – https://linktr.ee/daveasprey • Dave Asprey's Book: Smarter Not Harder – https://daveasprey.com/books • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.comTimestamps: • 00:00 Intro • 00:30 Introduction and Importance of Grass-Fed Barbecue • 01:03 The Ubiquity of Environmental Toxins • 01:39 Minimizing Exposure and Detoxification • 02:47 Introducing Jessica Berman and BodyBio • 04:41 Understanding Cell Membranes • 08:55 Phosphatidylcholine and Its Benefits • 27:54 Clinical Observations and Future Research • 36:49 The Reality of Modern Toxins • 37:00 Understanding Lipophoric Toxins • 37:44 Detoxification Strategies • 38:30 The Role of Phospholipids • 39:16 Liver Health and Detox • 40:29 The Benefits of Tudca • 41:24 Choline and Fatty Liver • 42:20 Debunking TMAO Myths • 44:28 Soy Lecithin vs. Sunflower Lecithin • 47:21 Mitochondrial Health and Prenatal Care • 50:03 Biohacking for Healthy Aging • 55:35 The Importance of Phospholipids for Cognitive Health • 59:12 Mold Toxins and Health • 01:01:45 Building Resilient Humans • 01:05:02 Exclusive Offer for Listeners See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Successfully Developing High-Performing Heifers with Dr. Mike Van Amburgh from Cornell University

Play Episode Listen Later Oct 22, 2024 65:20

This Real Science Exchange podcast episode was recorded during a webinar from Balchem's Real Science Lecture Series. The primary goal of a replacement program is to raise the highest quality heifer that can maximize profits when she enters the lactating herd. She carries no limitations that would detract from her ability to produce milk under the farm's management system. Ideally, one would wish to optimize profits by obtaining the highest quality heifer at the lowest possible cost, usually in the least amount of time. Dr. Van Amburgh presents a snapshot evaluation of benchmarks to assess the potential quality of replacements. (3:47)When does the process of creating a quality heifer start? Probably before conception. In non-pasture herds, the first lactation cows giving birth to heifers produced about 1000 pounds more milk in the first two lactations. Heifers whose dams were supplemented with choline during the pre-fresh period had higher birth-to-yearling average daily gains and improved immunity. Choline also appears to enhance the quality of colostrum via increased absorption of IgG. This implies that maternal programming extends beyond the uterine environment via ingestion of milk-borne factors, known as the lactocrine hypothesis (14:29)After the calf is born, the goal is anabolism or growth. The dam communicates with the calf via colostrum to direct calf development after birth. Not only does colostrum provide immunoglobulins, but it also contains a large amount of nutrients and non-nutrient factors that support gut maturation. In particular, IGF-1 and insulin may act on receptors in the gut to stimulate cell proliferation, cell differentiation, and protein synthesis. Dr. Van Amburgh summarizes several studies that showed increased colostrum feeding improved pre- and post-weaning growth and development. While the immunoglobulin content of colostrum is essential for passive immunity, the other components in colostrum are responsible for the increased growth performance. (27:39)The hormones and growth factors in colostrum enhance protein synthesis, enzyme expression, and gastrointestinal tract development. This implies that the gut is now an even stronger barrier to infection, with more surface area for digestion and absorption, with an increased capacity to digest nutrients due to higher enzyme excretion. (36:33)To investigate the impact of non-nutrient factors in colostrum, studies were designed where calves were fed either colostrum or milk replacer with the same nutrient content. Glucose uptake was increased for colostrum calves even though both groups received similar nutrient content. Plasma glucagon was higher in colostrum calves, indicating better glucose status and higher reserve capacity. Plasma protein levels were higher in colostrum calves, suggesting more amino acids available for growth and protein synthesis. Plasma urea nitrogen was lower for colostrum calves, indicating fewer amino acids were used for gluconeogenesis leading to more efficient growth. (46:55)What happens to immune cells in colostrum? Leukocytes and other immune-related cells in colostrum are trafficked into the circulation of the calf. Maternal leukocytes can be detected in the calf by 12 hours, peak at 24 hours, and disappear by 48 hours. Long term, there appears to be greater cellular immunity in calves that received whole colostrum compared to cell-free colostrum. Uptake of cells from colostrum enhances cellular immunity in calves by providing, mature, programmed cells from the dam. (52:24)The take-home message for colostrum management is to feed colostrum for four days. Give first-milking colostrum within six hours of birth and again at 12 hours. Give second-milking colostrum for day two feeding and third- and fourth-milking colostrum for days three and four. (56:04)Dr. Van Amburgh answers a few questions from the webinar audience about dry cow management for colostrum quality and quantity, the impacts of pasteurization of colostrum on components, and the efficacy of colostrum replacers. Watch the full webinar at balchem.com/realscience. (58:25)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

How To Improve Embryo Implantation By Optimizing This Biomarker

optimizing optimal ultimate guide embryos ttc biomarker folate implantation amh sarah clark choline

Play Episode Listen Later Oct 21, 2024 41:11

We're digging into how to balance blood sugar when you are TTC. If your blood sugar is on a roller coaster every day, this can impact the menstrual cycle, disrupt ovulation, and negatively affect implantation. I know you may have been told that your blood sugar is normal. But is it optimal? Optimal biomarkers are needed for preconception health. You may be experiencing mood swings, poor sleep, sugar cravings, or you may feel hangry. This could be a sign that your blood sugar is imbalanced. So, how do we balance our blood sugar and get pregnant this year? In this episode, you'll learn: 1)What insulin resistance is, and why it matters when we are trying to conceive 2) How and when to test blood sugar 3) What it means for our fertility when we experience sugar cravings, mood swings, poor sleep, and that "hangry" feeling 4) How stress and sleep impact blood sugar 5) What high and low blood sugar means for fertility and health 6) How to balance blood sugar and the best diet to regulate your blood sugar --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

How Lipo-C Injections Boost Fat Loss and Energy

NeuroEdge with Hunter Williams

Play Episode Listen Later Oct 15, 2024 15:37

Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/

energy boost ingredients brain health fat loss anti aging closing thoughts b12 injections lipo liver health choline key benefits inositol coaching application

EP 350: Am I Taking the Right Prenatal Vitamin? with Ryan Woodbury

The Pregnancy to Parenting Show with Elizabeth Joy

Play Episode Listen Later Oct 14, 2024 67:44

Have you ever wondered what to look for in a prenatal? Ryan Woodbury is the cofounder of Needed, an amazing company that is changing the prenatal game. She answers all of your questions this episode about what to look for in a prenatal, what to avoid, and what to add in supplementation. Through navigating her fertility and nutrition journey, she realized most prenatal nutrition information and products fall far short of empowering real nourishment for mamas-to-be. Needed empowers women to meet their biochemical nutritional needs, and to find nourishment beyond nutrition through better products, better identification of nutrition needs, education and community to support nourishment beyond nutritional needs alone. Connect with Needed: https://thisisneeded.com Needed Instagram: https://www.instagram.com/needed Prenatal Guide: https://cdn.shopify.com/s/files/1/0195/3293/9328/files/Needed_What_to_Look_For_In_a_Prenatal.pdf?v=1614386021 Try Needed Prenatal (Use code: ESANDOZ20 for 20% off): https://thisisneeded.com/?rfsn=6288346.811807&utm_source=refersion&utm_medium=affiliate&utm_campaign=6288346.811807 Sponsors: OakEssentials: Get 15% off your first order at https://oakessentials.com promo code PARENT15 Connect with Liz https://www.instagram.com/esandoz/?hl=en Check out the BIRTH PLAN PREP COURSE code JOY20 https://www.Elizabethjoy.co Get the First Trimester Survival Guide https://elizabethjoy.co/freebie Birth Plan Guide https://elizabethjoy.co/birth-plan-freebie Become a Doula! https://elizabethjoy--theautonomymommy.thrivecart.com/academy-bonus-bundle/

nutrition motherhood pregnancy vitamins doula momlife prenatal maternal health woodbury choline

How To Naturally Boost Estrogen and Get Pregnant

Play Episode Listen Later Oct 7, 2024 42:29

We're digging into how to boost estrogen levels naturally to improve pregnancy success. Many of us are struggling with symptoms such as hot flashes, night sweats, low libido, and irregular or absent periods. Your doctor may have told you to rush to IVF or that donor eggs were your only hope. Maybe they told you to get on hormone replacement therapy (HRT) right away to protect your heart and your bones. But why is your estrogen low, and how do you boost it naturally? Let's figure out the factors that influence estrogen and the steps you can take right now to improve pregnancy success. In this episode, you'll learn: 1) The most common signs of low estrogen and why going on HRT is a band-aid approach and doesn't uncover the reason it's low in the first place 2) The factors that influence estrogen (i.e. thyroid, gut microbiome, adrenals, mineral deficiencies) 3) Specific steps to take right now to balance hormones and improve estrogen levels --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

boost naturally ivf ultimate guide hrt estrogen ttc get pregnant folate amh sarah clark choline

Understanding Choline: An Overlooked Nutrient in Pigs and Chickens with Dr. Digler from the University of Illinois

Play Episode Listen Later Oct 1, 2024 61:33

This episode of the Real Science Exchange podcast was recorded during a webinar from Balchem's Real Science Lecture Series. Choline was discovered in 1862 in pig and ox bile (“chole” in Greek). It is a simple nutrient containing five carbons and a nitrogen. Choline is considered a quasi-vitamin since its requirements and de novo synthesis are both higher than the B vitamins it's similar to. Pigs can synthesize more choline than chickens. Choline is considered to be a conditionally essential nutrient depending on the physiological stage and choline production ability of the species being considered. (3:29)Choline is involved in cellular maintenance and growth at all life stages. In particular, it's involved in neurotransmission as a component of both sphingomyelin and acetylcholine. Phosphatidylcholine is a major component of cellular and organelle membranes and is involved in lipoprotein synthesis for the transport of lipids. Choline is converted to betaine upon oxidation, and betaine plays an important role in one-carbon metabolism as a methyl group donor. (8:43)Dietary-free choline is preferentially used for acetylcholine and phosphatidylcholine synthesis. Phosphatidylcholine is the most abundant form of choline in the body. In general, water-soluble forms of choline are absorbed faster and have a higher tissue incorporation rate than lipid-soluble forms. (14:58) Clinical signs of choline deficiency include reduced growth and reproductive performance. In pigs and chickens, choline-deficient diets lead to lipid accumulation in the liver. In broiler chickens, perosis is a classic choline deficiency sign and may progress to slipped tendons. From human studies, we know that insufficient methylation capacity during early development increases the risk of neural tube defects and impaired cognitive function. (16:44)As animals age, their dietary source of choline transitions from water-soluble forms to lipid-soluble forms. Mammalian young receive water-soluble choline from milk, and avian species from the egg yolk. After weaning in pigs and at the hatch in chickens, the dietary choline source transitions to lipid-soluble forms found in oilseed meals. Dr. Dilger goes on to describe choline concentrations in common feedstuffs and supplements. Feedstuff type and processing methods have a profound influence on bioavailable choline content. (19:16)Dr. Dilger details some of his work with choline and betaine in poultry diets. The requirement for preformed choline is relatively high for poultry because they lack capacity in a particular methyl transferase enzyme responsible for de novo synthesis. They also have relatively high choline oxidase activity which favors the formation of betaine from choline. Betaine is critical as a buffer to counteract the toxic effects of uric acid in the avian kidney. Dr. Dilger describes choline dietary requirements for avian species. (27:38)Pigs have more efficient methyl transferase activity for de novo synthesis of choline. Sufficient choline is provided by milk and practical diets. For growing pigs consuming corn-soybean meal diets where methionine can completely spare choline, there is little benefit of choline supplementation for growth. Choline requirements increase for gestating and lactating sows. Swine requirements for choline were set in the 1940s and 1950s. Dr. Dilger believes these requirements need a second look given the great changes in pig and crop genetics since the requirements were originally established. To that end, work in his lab has shown that choline intake during gestation and lactation influences sow milk composition, body choline concentrations and forms, metabolomic profiles and brain development of pigs. (35:18)In conclusion, Dr. Dilger considers choline a pervasive nutrient due to its crucial metabolic roles. Species-specific idiosyncrasies drive choline requirements, and analytical data for choline-related compounds is lacking. Different forms of choline have different metabolic kinetics and the potential for choline deficiency remains a practical issue. (46:15)In closing, Dr. Dilger answers an extensive set of questions from the audience. Watch the full webinar at balchem.com/realscience. (48:32)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Decreasing Choline Intake?

intake decreasing replying choline

Play Episode Listen Later Sep 28, 2024 4:26

Replying to a comment I received asking how to decrease Choline intake. Disclaimer: This video is strictly for educational purposes. It is not a substitute for seeking professional medical help. Have Questions/ Comments? I can answer them in an upcoming episode. Instagram: https://www.instagram.com/howardsblend/ TikTok https://www.tiktok.com/@howardsblend Send me an email smbsupps@gmail.com Resources: https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/#h3 https://lpi.oregonstate.edu/mic/dietary-factors/L-carnitine#food-sources https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302777/

Q&A: The Evidence on Choline and How to Prepare for Precipitous Labor

Pregnancy Podcast

Play Episode Listen Later Sep 25, 2024 15:14

In this episode, we explore two questions. First, we break down the role of choline in pregnancy, including its benefits for fetal brain development. We review the current evidence and provide practical tips on how to ensure you're getting enough choline from your diet or supplements. Next, we dive into precipitous labor, when labor progresses rapidly—and discuss what you can do to prepare for a fast labor. Thank you to our sponsor 20% off Mommy Steps or Form insoles with the promo code FEET. Studies show pregnancy can make your feet grow. In one study, 61% of participants had a measurable increase in foot length, and 22% reported going up a shoe size. The thought of going up a shoe size and having to replace every pair of shoes you own might freak you out. The good news is that wearing insoles can protect your feet from going up in size. Read the full article and resources that accompany this episode. Join Pregnancy Podcast Premium to access the entire back catalog, listen to all episodes ad-free, get a copy of the Your Birth Plan Book, and more. Check out the 40 Weeks podcast to learn how your baby grows each week and what is happening in your body. Plus, get a heads up on what to expect at your prenatal appointments and a tip for dads and partners. For more evidence-based information, visit the Pregnancy Podcast website.

labor feet studies choline precipitous pregnancy podcast

ADSA 2024 - Balchem Of Interest Research

Play Episode Listen Later Sep 17, 2024 62:39

Balchem sponsored several abstracts presented at the 2024 ADSA Annual Meeting. This episode consists of five segments, each focused on an abstract.Segment 1: Evaluating the total mixed ration stability of rumen-protected lysine products.Guests: Kari Estes, Balchem; Dr. Mark Hanigan, Virginia TechThis research compared the TMR stability of a Balchem prototype, several commercially available rumen-protected lysine products and a positive control of unprotected lysine. (3:39)A sample of TMR and the equivalent of one gram of lysine from each product were mixed and placed in a plastic zip bag for 0, 6, 12, or 24 hours. After each time point, the sample was placed in a strainer bag, dipped in distilled water, and drip-dried. The solution was collected and analyzed for free lysine content. (5:28)About 85% of the unprotected lysine was recovered at 0 hours. After 24 hours, around 50% was recovered. The rumen-protected lysine products varied widely; one product released nearly 87% of its lysine in 24 hours, while another only released 9%. TMR stability should be taken into account when determining feeding rates and handling of rumen-protected lysine products. (7:19)Segment 2: Evaluating the total mixed ration stability of rumen-protected choline products.Guests: Kari Estes, Balchem; Dr. Mark Hanigan, Virginia TechIn this experiment, Kari evaluated TMR stability of five commercially available rumen-protected choline products, along with a positive control treatment of unprotected choline chloride. (14:04)At 0 hours, about 80% of the unprotected choline was recovered and 50% was recovered at 24 hours. Results for the rumen-protected choline products were highly variable, ranging from 5% release to 100% release at 24 hours. Rumen-protected choline products should be evaluated for TMR stability in addition to rumen stability and intestinal release. (17:25)Segment 3: Effect of dry period heat stress and rumen-protected choline on productivity of Holstein cows. Guests: Maria Torres de Barri and Dr. Geoff Dahl, University of FloridaThe experiment had four treatments: heat stress with and without rumen-protected choline, and cooling with and without rumen-protected choline. Cows in the cooling treatment were provided shade, soakers, and fans, while cows in the heat stress treatment were only provided shade. (24:45)Heat-stress cows had higher rectal temperatures and respiration rates than cooled cows. Heat-stress cows also had lower dry matter intakes, shorter gestation length, lighter calves, and produced less milk. (29:36)For cows in the cooling group, choline supplementation increased milk production. However, cows in the heat stress group supplemented with choline produced less milk than cows who did not receive choline. (31:04)Dr. Dahl suggests that not cooling cows in heat-stress environments when they're receiving choline will not result in optimal results. (33:49)Segment 4: Effects of dietary rumen-protected, ruminal-infused, or abomasal-infused choline chloride on milk, urine, and fecal choline and choline metabolite yields in lactating cows. Guests: Mingyang (Charlie) You and Dr. Joe McFadden, Cornell UniversityThis experiment evaluated early and late lactation cows supplemented with choline via three different methods. Each treatment had 12.5 grams of choline ion provided daily: fed in rumen-protected form, continuously infused into the rumen, or continuously infused into the abomasum. (36:29)Choline bioavailability was influenced by the delivery method of choline. Fecal and milk choline concentration was only observed in early lactating cows with abomasal infusion. Abomasal infusion increases the choline metabolite betaine in feces and urine. These results suggest there is potential saturation of choline metabolism in the lactating cow. (40:53)Segment 5: The metabolic fate of deuterium-labeled choline in gestating and lactating Holstein dairy cows. Guests: Dr. Tanya France, University of Wisconsin; Dr. Joe McFadden, Cornell UniversityDr. France explains that choline can be metabolized via two different pathways. Using deuterium-labeled choline (D-9 choline) allows researchers to know which pathway is used. If D-3 or D-6 choline is measured, the methionine cycle is used, and if D-9 choline is measured, the CDP choline pathway is used. The hypothesis was that the physiological stage (late gestation vs early lactation) would influence choline metabolism. (51:06)Dr. France found that both choline metabolism pathways were used in both physiological stages. This experiment also confirmed that choline is a methyl donor and that choline recycling can occur. The research also evaluated the relative amounts of choline and choline metabolites in each pool. (53:40)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table. If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Why Addressing Homocysteine Levels Can Boost Egg and Sperm Health

health addressing boost levels optimal ultimate guide sperm ttc mthfr folate amh sarah clark choline homocysteine fab fertile

Play Episode Listen Later Sep 9, 2024 38:57

We're digging into how homocysteine impacts fertility. Our goal at Fab Fertile is to reduce inflammation in your body and boost your immune system so you can prepare for pregnancy success. But how can you tell if you have inflammation in the body? A good marker to get tested is your homocysteine. Optimal homocysteine levels are crucial for overall health and high levels can lead to inflammation. Plus, healthy homocysteine levels are essential for egg and sperm health. So, what are the exact steps to improve homocysteine levels and get pregnant this year? In this episode, you'll learn: 1) What is homocysteine, and why does it matter for fertility (i.e., ovulation, egg health, sperm health, embryo quality, implantation, and pregnancy outcomes) 2) What are the optimal reference ranges for healthy homocysteine levels in the blood 3) Which foods can help improve homocysteine levels 4) Which supplements can help with homocysteine levels (i.e., MTHFR gene variant (60-80% of us have this variant) and how can this impact homocysteine) --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I just put together a new guide, “Reconnecting With Your Fertility: Preparing Your Body With Diet” that I'm going to give you pro bono (aka, free

Top Fertility Supplements You Must Have To Get Pregnant This Year

supplements fertility ultimate guide foundational ttc get pregnant folate amh fsh sarah clark choline

Play Episode Listen Later Aug 26, 2024 41:38

We're digging into the top fertility supplement that you must have to improve pregnancy success this year Most people who are trying to conceive know that they need to take some supplements. After all, it's difficult to get essential nutrients from our food because the soil is so depleted. You've probably scoured the internet trying to determine which supplements will boost egg and sperm health. But what if you are taking the wrong ones? Or worse yet, you just have expensive pee. Yup, we see this all the time. More is not always better. We're breaking down our must-have fertility supplements, so you don't waste time and money taking the wrong ones, and you can improve pregnancy success this year. In today's episode, you'll learn: 1) Foundational supplements to enhance male and female fertility 2) Which supplement helps with egg quality, reduces the risk of early miscarriage and helps with the production of healthy sperm 3) Supplements that help with sperm quality and motility 4) How this supplement can balance estrogen for women and testosterone for men - plus increase libido for both sexes --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I'm excited to announce that our Summer Fertility Recipe Guide is ready! Go to FertilityDietFreebie.com to grab your copy. I worked with a chef/nutritionist to prepare these summer recipes. This is a five-day challenge where you'll learn how food impacts your body while enjoying delicious and nutrient-dense recipes all designed to enhance fertility (especially if you have low AMH and/or high FSH). The guide includes a meal plan and grocery shopping list. Start this challenge with your partner. --- Fab Prenatal includes all the essential nutrients to help support a healthy mom and growing baby throughout her pregnancy journey. Our blend was created to assist the gap you may be lacking in your diet for extra nutrient needs in pregnancy, like Folate, other B vitamins, Choline, and more. Use code “GPN15” for 15% off your order at FFLNaturals.com --- Join my FREE Facebook group and get my training on HOW to improve pregnancy success with your own eggs. https://www.facebook.com/groups/451444518397946 --- Check out https://www.fabfertile.com/blogs/podcasts/top-fertility-supplements-you-must-have-to-get-pregnant-this-year/ --- Please note when promoting a product, we only select products that either Sarah Clark or her team has tried and believe are beneficial for someone who is TTC. We may receive a small commission.

Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Huberman Lab

Play Episode Listen Later Aug 14, 2024 103:13

I'm honored to share Episode 10, the final episode of Season 1 of Perform with Dr. Andy Galpin. Dr. Andy Galpin is a tenured full professor at California State University, Fullerton, where he co-directs the Center for Sport Performance and leads the Biochemistry and Molecular Exercise Physiology Laboratory. Andy is both a friend and a colleague, and I'm delighted to have assisted in the creation of this podcast. I'm certain you'll both enjoy and learn from it. Season 1 featured 10 episodes, where Dr. Galpin covered everything from building strength, the importance of strength for long-term health, the science of breathing, the benefits of sleep extension, genetic testing for personalized training, and nutrition for injury recovery. While we have Episode 10 of Perform with Dr. Andy Galpin here, please be sure to follow Perform with Dr. Andy Galpin on your preferred platform to listen to all the episodes from Season 1 and to get notified when Season 2 is released. Show notes for this episode can be found at performpodcast.com. Timestamps 00:00:00 Introduction from Dr. Andrew Huberman 00:01:08 Brain Health & Injury 00:05:06 Sponsors: LMNT & Continuum 00:08:16 Nutrition & Supplements for Brain Injury 00:12:44 Brain Injury Categories, Traumatic Brain Injury (TBI), Concussion 00:17:09 Brain Injury Pathophysiology 00:22:16 Burst Capillaries, Initial TBI Response 00:30:03 Delayed TBI Response, Neuroinflammation 00:34:19 Sponsors: Momentous & Maui Nui 00:36:52 Creatine Monohydrate; Second Impact Syndrome 00:41:52 Strength of Evidence Scale, Creatine 00:47:15 Creatine Doses, Frequency, Adverse Issues; Food Sources 00:53:22 Sponsors: AG1 & David Protein 00:56:05 Fish Oil, DHA, EPA 01:00:38 EPA & DHA Dosage, Timing, Adverse Issues; Food Sources; Omega-3 Index 01:04:46 Vitamin B2 (Riboflavin), Vitamin B 01:08:57 Riboflavin Dosages, Timing; Food Sources 01:11:25 Choline 01:18:37 Choline Supplements & Food Sources, Alpha GPC, Dosage 01:21:30 Branched-Chain Amino Acids (BCAAs), Sleep 01:25:04 BCAAs Dosage, Whole Food Sources 01:28:02 Magnesium 01:31:20 Magnesium Dosage, Timing, Supplements, Adverse Issue; Food Sources 01:33:09 Blueberry Anthocyanins 01:35:28 Anthocyanins Dosage; Food Sources 01:37:17 Caffeine & Brain Injury Recovery 01:38:50 Perform Episodes, Perform Newsletter, Acknowledgements 01:41:19 Zero-Cost Support, YouTube, Spotify & Apple Subscribe & Reviews, Sponsors, YouTube Feedback, Social Media 01:42:56 Conclusion by Andrew Huberman Disclaimer

Why Addressing Digestive Symptoms Can Improve Reproductive Health with Dr. Melanie Keller

Play Episode Listen Later Aug 12, 2024 54:59

We're digging into what IBS/SIBO has to do with reproductive health. So many of us are experiencing digestive complaints such as loose stools, constipation, bloating or gas. And while these may be common, they are certainly not normal. When you're trying to conceive, they are a clue to dig deeper. This is especially true if you've been diagnosed with the catch-all diagnosis of irritable bowel syndrome (IBS). So, what can you do to address IBS, and why are these embarrassing symptoms linked to fertility? I'm excited to welcome Melanie Keller to the podcast. Melanie is a leading global pioneer in the revolutionary treatment of IBS/SIBO, with an astounding success rate of 90% and permanent results in 12 weeks or less. Her innovative and successful treatment has garnered recognition in top-tier media outlets such as Forbes Health, Well+Good, and ABC's "The List TV." Her innovative way of thinking and providing clarity in application are at the forefront of her precision medicine approach to health and well-being. In this episode, you'll learn: 1) What IBS is, and what you can do to address the symptoms (plus why it matters if we're trying to conceive) 2) The connection between IBS and SIBO (small intestinal bacterial overgrowth) 3) Steps to take to improve IBS symptoms plus supplements and diet/lifestyle strategies Free micro meditation - https://mailchi.mp/adad6ee73c76/intuitiveedge --- RESOURCES: Fab Fertile Method https://www.fabfertile.com/what-we-do/ Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH - https://fabfertile.clickfunnels.com/optinvbzjfsii --- I'm excited to announce that our Summer Fertility Recipe Guide is ready! Go to FertilityDietFreebie.com to grab your copy. I worked with a chef/nutritionist to prepare these summer recipes. This is a five-day challenge where you'll learn how food impacts your body while enjoying delicious and nutrient-dense recipes all designed to enhance fertility (especially if you have low AMH and/or high FSH). The guide includes a meal plan and grocery shopping list. Start this challenge with your partner. --- Fab Prenatal includes all the essential nutrients to help support a healthy mom and growing baby throughout her pregnancy journey. Our blend was created to assist the gap you may be lacking in your diet for extra nutrient needs in pregnancy, like Folate, other B vitamins, Choline, and more. Use code “GPN15” for 15% off your order at FFLNaturals.com --- Join my FREE Facebook group and get my training on HOW to improve pregnancy success with your own eggs. https://www.facebook.com/groups/451444518397946 --- Check out https://www.fabfertile.com/blogs/podcasts/why-addressing-digestive-symptoms-can-improve-reproductive-health-with-dr-melanie-keller/ --- Please note when promoting a product, we only select products that either Sarah Clark or her team has tried and believe are beneficial for someone who is TTC. We may receive a small commission.

abc addressing symptoms ultimate guide ibs reproductive health sibo digestive ttc folate amh fsh sarah clark choline list tv ibs sibo forbes health melanie keller

How To Prevent Cancer and What To Do If You've Been Diagnosed With Cancer While TTC with Katrina Foe