Root of the Cause Radio

My guest this episode is Roxanne Grobbel, leading expert in EMDR (Eye Movement Desensitization and Reprocessing). Listen as Roxanne demystifies EMDR and teaches us just how effective and well researched this treatment is.Roxanne is a certified EMDR therapist and consultant. With a career focused on trauma-related issues, she is widely considered one of the leading experts on EMDR today. Roxanne is also an EMDRIA-approved EMDR instructor, teaching clinicians both basic and advanced EMDR courses and traveling around the country conducting workshops and lectures. Roxanne currently provides intensive trauma treatment at the 11th Hour Trauma Retreat in Denver, Colorado.emdria.orgwww.insightcounselingandeducation.com or www.Center4emdr.com EMDRrox@gmail.com 2:49-What is EMDR?5:40-The connection between R.E.M. and EMDR8:33-Taxation of working memory while doing a secondary task. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4325664/#S1title10:38-What to expect from your first EMDR session14:44-How does an EMDR practitioner extract repressed traumas that are driving a fear, phobia or anxiety?23:37-Is EMDR effective for everyone? Is there an efficacy spectrum?26:12-Reasons for non-responders29:55-Is EMDR for trauma-related struggles only?36:25-The impact environment has on children aged 0-3 and how the practitioner taps into a trauma their patient was too young to remember (as opposed to a repressed memory)For questions or to request future show topics, email ROTC@rootofthecause.net.

In this episode of Root of the Cause Radio, I'll be covering the good, the bad and the ugly of estrogen metabolites: the more benign 2-Hydroxyestrone, the duality of the 16-Hydroxyestrone and the dreaded 4-Hydroxyestrone. 1:53 - Phase 1 estrogen detoxification and estrogen metabolites 2:47 - 16-Hydroxyestrone, the impact, risk and reasons for high levels and the possible downsides of very low levels 4:06 - Can Estriol convert into anything harmful or helpful? 5:40 - The bad and ugly of the 4-Hydroxyestrone and how methylation plays a critical role 7:42 - Phosphatidylcholine and how it can indirectly help to neutralize the 4-Hydroxyestrone metabolite 9:23 - What happens to the 4-Hydroxyestrones that don't get methylated? Hint: DNA damage 9:42 - How sulforaphane stimulates glutathione S transferase and quinone reductase to mop up DNA damaging quinones 11:12 - Can you measure quinone levels? Can you measure DNA damage from oxidative stress (8-hydroxy-2-deoxyguanosine)? 12:00 - How glutathione is made and the critical nutrients necessary 13:49 - How glutathione and sulforaphane impact estrogen metabolites that don't get methylated

Today's episode is part 2 of my 3-part series on estrogen, where I'll be covering the nuts and bolts of how we properly eliminate estrogen from the body, what's needed to do so and some reasons for why that process may become suboptimal. I also discuss the timing of testing as well as how and why that detail can render greater value for some people. 2:58 - Does the day of the month you test for estrogen matter? If so, when should you test and why 4:52 - Mid-luteal phase of the menstrual cycle and its importance with estrogen testing 6:24 - Estrogen clearance 101 6:52 - The gallbladder's, liver's and bile's impact on estrogen clearance 7:53 - Bile production, bile flow, bile acids vs. bile salts and glycine/taurine and how they all impact estrogen clearance 9:50 - Phosphatidylcholine, PEMT gene and their impact on bile and the gallbladder 11:13 - Gut dysbiosis 14:11 - Calcium D-glucarate 15:29 - Some potential reasons for high estrogen in men

Today begins part 1 of my 3-part series on estrogen. I believe estrogen to be a very misunderstood hormone in the body, which is why I decided to use this platform to break down the finer points of estrogen, not only for women but for men as well. 2:30 - Estrogen basics in women 4:12 - Estrogen, bone density and PTH's (parathyroid hormone's) interplay 5:05 - How estrogen is made in men 6:18 - The aromatase gene (CYP19) 7:07 - Effects of high and low estrogen in men 10:16 - The 3 main estrogens and the pros, cons and limitations within the various testing methods 14:35 - SHGB (sex hormone-binding globulin) 19:42 - Estrogen metabolites (2-, 4-, and 16-Hydroxyestrones) and the value of knowing your levels

In this episode, we cover leaky gut, immune modulation, cancer, IGF1, growth hormone, pathogens and liposomal delivery systems, just to name a few. My guest today is Douglas Wyatt. Doug is the founder of Sovereign Laboratories, which provides the most efficacious bovine colostrum for immune resilience and maintaining homeostasis. Colostrum has been shown to help restore gastrointestinal damage caused by leaky gut, a primary cause of chronic disease. As Director of Research for the Vibrant Life Institute, Doug is the leading expert in colostrum and is credited with reintroducing bovine colostrum for human use. Mr. Wyatt is also a proponent of colostrum's unique and powerful bioactive components that show incredible promise for turning the tide on the prevention and treatment of the world's increasing chronic disease epidemic. 2:10 - Doug's story of his serendipitous discovery of colostrum and how he became a leading authority on the subject  12:08 - What is colostrum? What is its biological purpose and function for a newborn child?  17:05 - The effects on infants who do not receive colostrum and what can be done to remedy that 19:33 - What else can colostrum do other than what it's most known for – healing leaky gut? Contains lactoferrin (antimicrobial, inhibits viral replication, iron sequestrate), immunoglobulins (aids in fighting pathogens), polypeptides (immune modulatory) 29:48 - Colostrum…immune “booster” or immune modulatory and what the difference is  35:20 - Liposomal turmeric and vitamin C  38:56 - What liposomal is and why liposomal colostrum is superior 44:00 - Leaky gut. Is it real? If so, how to test for it?  48:59 - Secretory IgA (the gut's immune system) in the context of colostrum 51:33 - The IGF1/growth hormone with colostrum, cancer and if there are possible concerns

The final installment with Dr. Mensah, where we continue to take a deep dive into undermethylation. 1:03 - Quantifying the severity of undermethylation using the whole blood histamine marker, and the thresholds that begin to hinder versus enhance performance 8:35 - Calcium supplements for undermethylation, the mechanism and the potential down sides 12:07 - Dr. Mensah's thoughts on the enzyme catecol-O-methyltransferase (COMT) and what, if anything, can be extrapolated from knowing your COMT status 14:52 - Dr. Menshah feels undermethylating people are sensitive to folate. Should they then want to induce a mild deficiency? 18:24 - SSRIs for someone with high histamine vs. SSRIs for someone with optimal histamine levels, or…is it copper overload? 23:52 - Dr. Mensah's thoughts on genetic tests for pharmaceutical use http://www.genesight.com (Genesight.com)  25:44 - Dr. Mensah's thoughts on receptor down regulation concerns with SSRI medication 28:00 - Zinc and its role in methylation, serotonin production and mental health 29:13 - Dr. Mensah's thoughts on 5HTP supplementation https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid)Mensahmedical.com Listen to the Accompanying Episode Here: https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939 (Methylation: A Primer to My interview with Dr. Albert Mensah) Email ROTC@rootofthecause.net to ask a question or request a future episode.

Part two of my three-part series with methylation expert Dr. Albert Mensah. 1:40 - Is it ever appropriate and/or helpful to combine pharmaceutical approaches with nutraceutical strategies for mental health in the context of methylation? 4:13 - SAMe – a natural SSRI? 7:35 - The SERT gene, SAMe, folate and various other ways one's methyl status impacts serotonin 10:20 - SAM to SAH ratio test: how and why this test can render actionable data http://www.doctorsdata.com/Methyla5on-Pro%EF%AC%81le-plasma (Methylation profile/SAM to SAH ratio test) 17:50 - Ways the SAM to SAH ratio test can become skewed 11:50 - What actually is homocysteine both in the context of methylation and in general? Do homocysteine levels correlate to methyl status? 26:15 - Glycine: have this amino acid's methyl-buffering effects been overstated? 28:50 - Methionine: the concerns over excess methionine. Overstated and out of context? 31:17 - Folate, folic acid and cancer 32:40 - Folate pathway via MTHFR. Is it the main pathway, as most “experts" would have you believe, or is it the backup pathway to re-methylating homocysteine? https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid)Mensahmedical.com Listen to the Accompanying Episode Here: https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939 (Methylation: A Primer to My interview with Dr. Albert Mensah)  Email ROTC@rootofthecause.net with your questions, episode requests or feedback.

Dr. Albert Mensah, MD, discusses cutting edge (and affordable) ways to test for undermethylation, plus its mental health implications, nutraceutical solutions, pharmaceutical options and much more. Dr. Mensah is the founder of Mensah Medical, an international biomedical clinic for patients diagnosed with autism, ADD, ADHD, OCD, Alzheimer's disease, Parkinson's disease, bipolar disorder, anxiety, depression and eating disorders. He treats patients with advanced nutrient therapy, an effective and natural alternative to prescription medication. Answering the need for specialists with backgrounds in both traditional and natural medicine, Dr. Mensah founded Mensah Medical after serving as a primary physician at the original Pfeiffer Treatment Center. While at Pfeiffer, he received extensive training from Dr. William J. Walsh, PhD, founder and former director of the Walsh Research Institute and a pioneer in methylation and mental health research.  Dr. Mensah works closely with the Walsh Research Institute, updating therapies and protocols, initiating cutting-edge paradigms and serving as a clinical instructor for its International Doctor Training Program. 3:38 - What is methylation? 7:00 - Serotonin production, activation, recycling and reprocessing 9:03 - Whole blood histamine blood marker and its implication in methylation. The personality characteristic often seen in those with high whole blood histamine (undermethylators) and the advantages and struggles undermethylators are prone to 12:26 - How and why there is an inverse relationship between methyl and histamine 13:53 - How Dr. Mensha approaches a treatment plan for a high histamine individual 15:56 - Can a genetic polymorphism (SNP) for histamine skew the whole blood histamine levels that would otherwise correlate to methylation? 18:03 - Are whole blood histamine levels genetically determined or can they be altered if one “fixes” their undermethylation issues? 19:06 - Why do many undermethylators do well on the supplement SAMe and don't do as well when folate and/or folic acid is added to the SAMe? 20:25 - Folate/folic acid – methylating agent or demethylating agent? Or both?? 22:30 - Selective serotonin reuptake inhibitor (SSRI) and the biochemical rationale behind this class of drugs 25:53 - Why undermethylators tend to be hyper responders to SSRIs 27:06 - Folate – select serotonin re-uptake enhancer? Folate contraindicated in undermethylators despite contrary popular belief?  29:45 - When and why to take and not take folate, irrespective of methyl status, particularly during pregnancy 30:42 - The potential issues with haphazardly taking folate and/or folic acid during the entire pregnancy due to folate being a “double agent” 31:35 - How the increased use of folic acid has contributed to global epigenetic changes 32:03 - Dr. Mensah further explains how folate/folic acid is a “double agent” 36:06 - Is methyl-folate as effective as it's thought to be, and why? 41:21 - Which type of B12 is best for undermethylators and balanced types? Methylcobalamin, Cyanocobalamin, Hydroxocobalamin? https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid)Mensahmedical.com Listen to the Accompanying Episode Here: https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939 (Methylation: A Primer to My interview with Dr. Albert Mensah) For questions or requests for future show topics, email ROTC@rootofthecause.net.

Today I'm doing a solo episode covering key concepts I discuss in my upcoming interview with one of the leading experts on methylation today, Dr. Albert Mensah. Dr. Mensah was in the game many years prior to the word methylation even becoming part of the functional medicine vernacular. He mentored under Dr. William Walsh, who started doing groundbreaking work on methylation in the mental health sphere decades before MTHFR became a trendy buzz term and years before methylation was at all talked about outside of academic circles. Dr. Mensah is part of this lineage of the great pioneers in the field of methylation research, and as such, you'll see that his knowledge in this area knows no bounds. With that said, I felt that doing a solo episode to provide some background information and a better understanding of some of the advanced concepts we discuss would be of value. Look for my three-part interview series with Dr. Mensah, which will be released in the coming weeks.  2:16 - Selective serotonin re-uptake inhibitor SSRI physiology 101 6:04 - How homocystein is biochemically made 7:30 - Methionine converting to S-adenosyl-L-methione (SAM) 8:03 - SAM converting to SAH 9:02 - The SAM to SAH ratio 9:55 - The methylation misconceptions of folate  12:14 - Selective serotonin reuptake enhancers  13:02 - gene polymorphism (SNP) 101 13:41 - Glycine in the context of methylation https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid) Email ROTC@rootofthecause.net with questions or requests for future episodes.

Today is part two of my two-part series with Robby Besner, where we continue to take a deep dive into all things sauna therapy, light therapy and detoxification. 0:58 - Demystifying red light and the difference between actual red light wavelengths and red light bulbs 5:19 - Therapeutic effects of the red Tri Light Panel 9:11 - What is Low Level Laser Therapy (LLLT) and how does it differ from the light from an infrared sauna? 14:53 - Electro Magnetic Frequencies (EMF) and Extremely Low Frequencies (ELF) regarding infrared saunas 26:02 - Infrared sauna therapy for cancer. Testing to determine if a cancer is heat sensitive and radiation sensitive (reference page 2, section 4 titled “Radiotherapy/Hyperthermia Sensitivity” of the https://www.rgcc-group.com/wp-content/uploads/2019/06/Assessment-patients-name-1.pdf (Heat Sensitive Cancer Test) 29:02 - Ozone therapy and its synergy with infrared sauna  32:52 - Mineral loss from sauna therapy and what to do about it 38:50 - Detoxing organophosphates using infrared sauna therapy https://www.greatplainslaboratory.com/gpl-tox (https://www.greatplainslaboratory.com/gpl-tox) 42:10 - The reason your head remains outside the sauna in Robby's sauna design  Therasage.com Instagram: @therasageinfrared Email ROTC@rootofthecause.net with any questions or comments.

Today is part one of my two-part series with guest Robby Besner. Robby is the founder of the company Therasage, through which he designs and sells full spectrum infrared saunas, among many other health optimization tools. He has an unusually unique and deep understanding of light therapy, heat therapy and detoxification in the form of sweating. Robby comes armed with the science behind all three of these powerful therapies. 1:45 - What is infrared light and why is it so often associated with saunas? 5:55 - The spectrum of the sun's rays and the crossover to when it changes from non-ionizing (healing) radiation to ionizing (potentially harmful) radiation 10:33 - Therapeutic benefits of the sun's wavelengths vs. an infrared sauna 14:02 - What is photobiomodulation? How do we get Vitamin D from the sun, and is that a form of photobiomodulation? 21:43 - DMinder app 26:48 - Hack to determine what Vitamin D level may be optimal for you 29:46 - Benefits of nitric oxide and how infrared light affects it (stimulating cytochrome c oxidase) https://therasage.com/ (Therasage.com) Instagram: @therasageinfrared Reach out to ROTC@rootofthecause.net with any questions, comments or episode requests.

If you're interested in reversing your coronary calcification and heart disease, today's episode takes a deep dive into just that. Biochemist Patrick Theut put in over 16,000 hours of intense research to address and resolve his own heart disease, and that healing journey led him to create THE most effective Vitamin K supplement on the market today: Koncentrated K. The Root of the Cause podcast welcomes Patrick to educate us on exactly how he did it. 3:14 - What is a coronary calcium score (CAC score)?  3:52 - Plaque vs. calcium 4:14 - Determining severity of the CAC score  8:36 - Overview of Vitamin K 12:14 - What is carboxylation and what is its role with Vitamin K dependent proteins?  12:58 - Does Vitamin K contribute to unwanted clotting? (Protein S, C, Z) 17:02 - The body making the type of K it needs with any form of K as a substrate (K1, K2,    Mk-7, Mk-4) 20:11 - Warfarin: contraindicated with K2? 21:23 - https://en.wikipedia.org/wiki/Dabigatran (Dabigatran): a work around to other Vitamin K blocking medications?  22:36 - Mk-4 vs. Mk-7 28:59 - Mechanism of action in calcium removal with Vitamin K2 35:00 - Foam cells, https://en.m.wikipedia.org/wiki/Autoschizis (Autoschizis)  38:26 - Vitamin K dosing for therapeutic purposes and for basic biological function  40:37 - Got a high coronary calcium score? What to do next 43:44 - Testing for Vitamin K status  52:08 - High risk for stroke and taking K1 54:39 - Statins and coronary calcium score 1:03:46 - Patrick's Vitamin K formulation and how it came to be  1:10:59 - Astaxanthin and its role in the Koncentrated K formulation For questions or requests of any kind, email ROTC@rootofthecause.net.

Dr. Brian Cornblatt joins me to unravel the unparalleled benefits of sulforaphane. Not only does he break down the science behind the detoxification capabilities of this potent phytochemical but he decodes the countless other profound uses of this remarkable compound as well. Dr. Cornblatt is a Johns Hopkins University School of Medicine graduate with a Ph.D. in Pharmacology and Molecular Sciences and a postdoctoral fellowship from the Johns Hopkins Bloomberg School of Public Health and Environmental Health Sciences Division of Toxicology. He is one of the leading experts on sulforaphane and THE leading expert on nutraceutical-based sulforaphane in the world today. Dr. Cornblatt is the creator of Avmacol, the most bioavailable glucoraphanin product that yields the highest amount of sulforaphane on the market. Avmacol is uniquely backed up by a robust supply of actual, verifiable clinical data, showcasing its broad range of powerfully therapeutic uses. 2:15 - Sulforaphane 101: a primer 4:22 - The story of how and why Dr. Cornblatt became so interested in the study of sulforaphane  10:00 - NRF2 and how sulforaphane affects it 11:56 - How sulforaphane is made and the varying degrees to which glucoraphanin converts to sulforaphane from person to person 16:13 - Glutathione, how it's made in the body and how sulforaphane impacts it  19:53 - Potential pitfalls of taking exogenous glutathione 21:50 - NAC with sulforaphane 25:09 - Heat shock proteins and sulforaphanes impact  28:48 - Sulforaphane and H-Pylori 31:49 - Innate vs. adaptive immune system  33:55 - Sulforaphane and autism 44:33 - Avmocal vs. consuming broccoli sprouts  46:21 - Why Avmocal is not actually sulforaphane  48:36 - Bioavailability of sulforaphane and Avmacol 52:47 - How much sulforaphane can one tablet of Avmacol render on average? 56:38 - Taking Avmacol with a sulfur sensitivity 58:50 - Avmacol vs. Prostaphane and the prostate 1:03:53 - Avmocal...Goitrogenic? 1:09:02 - Dr. Paul Saladino's concern with sulforaphane  1:14:58 - DIM vs. sulforaphane 1:19:14 - Sulforaphane, estrogen detoxification, quinone reductase 1:21:56 - Heterocyclic amines and sulforaphane  https://www.clinicaltrials.gov/ct2/results?term=avmacol&Search=Search (Avmacol Clinical Trials)  Avmacol.comFor questions or requests for future topics, email ROTC@rootofthecause.net

In today's episode, I'll be talking about the oral glucose tolerance test as well as sharing some biohacks you've never heard of before related to fasting, low carb diets and exercise hacks. I'll also be mentioning some other blood sugar markers and how they relate and compare to the oral glucose tolerance test and discussing whether there is a cheaper, more efficient and, arguably, more accurate alternative test. Hint: the answer is yes!

In today's episode, I'll be talking about the blood sugar marker fructosamine. I'll be comparing and contrasting it to the far more popular marker hemoglobin A1C.

In today's episode, I'll be discussing the good, the bad and the ugly of the blood sugar marker hemoglobin a1c. I'll be breaking down how this marker works on a physiological level as well as how it's used in the context of blood sugar regulation. I will elucidate some limitations and even potential pitfalls when using this marker. --- Send in a voice message: https://anchor.fm/rootcause/message

In today's episode, I'll be getting into the blood chemistry marker fasting blood sugar. I'll also discuss non-fasting blood sugar, some of the at-home biohacks you can do related to blood sugar as well as some of the various ways this test can be skewed and what to do about it.

In this episode I'll be giving an introductory primer to basic blood sugar physiology. What is glucose and how is it made? What is insulin and its role in blood sugar? What is glut 4 and its role? What role does GPL1 play? And much more.

This podcast will focus on discussing matters of health, fitness, nutrition, biochemistry, human physiology and biohacking of all kinds. This show came out of my burning desire to connect you guys to world class experts that I personally have the great fortune of talking to regularly, from doctors to exercise scientists, nutritionists, leading researchers - and the list goes on. Basically any and all people who will help me and my audience reach a level of peak performance both physically and mentally. I consider myself a curator of information, and in these interviews, I'll be teasing out all the complex scientific concepts and leaving you guys with actionable information to help you improve your quality of life. My goal is for these episodes to be fun and relaxed while still digging deep to obtain the answers to your burning questions.