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Ce soir, Frank et Émile font un gros update sur leurs vies : déménagement, vie de couple, finances, retour des vlogs, voyage à Vegas et même l'arrivée d'un chiot en studio!

Josh Duhamel first gained widespread recognition playing Leo du Pres on the TV soap opera All My Children, a role that earned him a Daytime Emmy Award. He went on to star in the NBC series Las Vegas and became internationally known for playing military officer William Lennox in the Transformers film franchise. In addition to acting in films and television, he has worked as a producer and director, expanding his career beyond on-screen performances. Catch is new movie ‘Neglected' out on VOD now and stay tuned for Season 2 of Ransom Canyon out on Netflix on July 23, 2026. IN THE NEWS: Trump draws much different reaction at NBA Finals than he did at CFP national title game, Karmelo Anthony sobs as he's convicted of murder for stabbing Austin Metcalf, Nick Reiner Claims He's Being Blocked From Inheritance Left Behind By Parents, Muslims go off on British children's book company for posting cartoon of lesbian mom in hijabGET IT ON!FOR MORE WITH JOSH DUHAMEL:MOVIE: NeglectedOut On VOD Now (Limited Theatrical on May 8th 2026)MEN'S WELLNESS COMPANY: GatlanBook Free Consultation @ gatlan.comT.V. SHOW: Ransom CanyonSeason 2 Releases On Netflix July 23INSTAGRAM: @ joshduhamelFOR MORE WITH RUDY PAVICH:DATES: WEBSITE: RudyPavichComedy.comINSTAGRAM: @ Rudy_Pavich PUNCH UP LIVE: https://punchup.live/rudypavichLIVE SHOWS: June 12 - Oklahoma City, OK (2 Shows)June 13 - Tulsa, OK (2 Shows)June 20 - Santa Ana, CA (KROQ Doc Screening)Thank you for supporting our sponsors:BetOnlineoreillyauto.com/ADAMPluto.tvPodcastOnerosettastone.com/ADAMSimpliSafe.com/ADAMSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send Vanessa a Text MessageA special listener discount is available for Mara Labs products featured in this episode: Explore Mara Labs (Code is VANESSA)If you enjoy the podcast and want to support Vanessa's work, you can do so here: Buy Me a Coffee – Intentionally WellIn this episode, I'm joined by David Roberts, founder of Mara Labs, for a conversation exploring cellular health, modern environmental stressors, and the body's natural resilience systems.David's journey into this space began after his late wife Mara's cancer diagnosis, which led him to deeply explore plant-based compounds and how they interact with cellular protection and repair mechanisms. That path eventually led to the development of BrocElite, a stabilized sulforaphane supplement designed to support detoxification pathways, mitochondrial function, and overall cellular resilience.We discuss topics including sulforaphane, oxidative stress, detoxification and autophagy pathways, metabolic health and GLP-1 signaling, genetic variability such as MTHFR and COMT, and how modern environmental exposures like microplastics may be impacting overall health.This is a wide-ranging conversation aimed at helping make complex biology more understandable and grounded in real-life application.Key Topics Covered: Sulforaphane and cellular defense systems  Detoxification pathways and autophagy  Mitochondrial health and oxidative stress  Modern environmental exposures (including microplastics)  Metabolic health and GLP-1 signaling  Genetic variability (MTHFR / COMT) and sensitivity  Why some people feel more reactive in today's environment Sulforaphane and pet health BrocElite and Mara Labs story Connect with David:Mara Labs on InstagramExplore Mara LabsConnect with Vanessa and the podcast: IWP Website: Intentionally Well PodcastIWP Recommended ProductsPodcast on InstagramVanessa on InstagramPodcast on YouTubeVanessa on TikTokVanessa on XEmail: intentionallywellpodcast@gmail.comSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

French Cheese: The Full Story is the most comprehensive episode Fabulously Delicious has ever made on French cheese — covering everything from the monastic origins of French cheesemaking to the raw milk collapse that has seen France lose ninety percent of its artisan cheese culture in a single lifetime. French cheese history, French cheese culture, practical French cheese guidance and a passionate argument for why one of the greatest food traditions in the world deserves your full attention.The episode begins with a statistic that stops most people in their tracks. Seventy years ago one hundred percent of French cheese was made from raw milk. Today that figure is ten percent. We go back to the beginning — the monastery cellars of the Benedictines and the Cistercians, the extraordinary story of Roquefort as the oldest legally protected food in the world, the history of Camembert and Brie, and the AOC and AOP system that protects French cheese today. The heart of the episode is a guide to the five families of French cheese — the framework that makes French cheese make sense. Fresh, bloomy rind, washed rind, pressed uncooked, pressed cooked and blue — each one explained through its most celebrated examples, from Époisses and Munster to Comté, Reblochon and Ossau-Iraty.The second half takes you on a regional tour of France through its greatest cheeses, goes inside the French fromagerie to explain exactly how to navigate one, covers how the French actually eat cheese and why they are right about almost all of it, and closes with the future of French cheese — the threats, the revival and why every choice you make at the cheese counter genuinely matters.If you have listened to the Fabulously Delicious episodes on Brie de Meaux, Abondance or Époisses, this episode is the full picture those episodes were drawn from. Search Fabulously Delicious on Spotify and Apple Podcasts for more French food stories every week.My book Paris: A Fabulous Food Guide to the World's Most Delicious City is your ultimate companion. This is a new 2026 update for the book and you'll find hand-picked recommendations for the best boulangeries, patisseries, wine bars, cafés, and restaurants that truly capture the flavor of Paris. You can order it online at andrewpriorfabulously.com For those who want to take things further, why not come cook with me here in Montmorillon, in the heart of France's Vienne region? Combine hands-on French cooking classes with exploring charming markets, tasting regional specialties, and soaking up the slow, beautiful pace of French countryside life. Find all the details at andrewpriorfabulously.comYou can help keep the show thriving by becoming a paid subscriber on substack where you'll also get fabulous extra content. Every contribution makes a huge difference. Join here at Substack Merci beaucoup!Newsletter Youtube Instagram Facebook Website #FrenchCheese #FrenchCheeseHistory #FrenchFoodPodcast #FabulouslyDelicious

Updated Re-Release: This episode originally aired a few years ago and has since become one of The Earful Tower's most beloved classics. We're bringing it back today because some things are simply too good - and too instructive - to stay buried in the archives. It started with a photo. A single, damning image shared on The Earful Tower's social media: an 18-month-old Comté, massacred at a Parisian dinner party by the hand of a newly arrived American. The picture went viral inside the Earful community almost instantly, and the culprit, Will Weaver, a Texan fresh off the plane, became the talk of the group. So we did what any responsible France-based podcast would do: we launched a full investigation. In this episode, you'll hear from genuinely mortified cheesemongers, some committed dramatic performances from Earful VIPs, and crucially the full account from Will Weaver himself, the man holding the knife that fateful evening. Yes, we find out exactly what he did, why he did it, and whether he has shown any remorse whatsoever. We also get into the real, legitimate, no-nonsense guide to how you are actually supposed to cut a Comté — because this is a safe space for learning, not just judgement.  A word of warning before you dive in: a lot of this episode is firmly tongue-in-cheek, so take the drama with a generous pinch of salt. The cheese-cutting advice, however, is completely genuine. If the episode sends you running to the nearest fromagerie, the spots mentioned in the show is worth a visit: Griffon Fromager in Paris's 7th arrondissement (23 bis Av. de la Motte-Picquet, 75007 Paris) and we also recorded at bar of the legendary Le Bristol Paris (112 Rue du Faubourg Saint-Honoré, 75008 Paris). Both are excellent.  The music is from Pres Maxson.  This episode is brought to you by The Earful Tower Tours. Whether you're exploring the Marais, scaling Montmartre, or wandering the Latin Quarter, our walking tours are among the highest-rated in Paris — and the best possible way to experience this podcast in the flesh. The Earful Tower stays independent thanks to its members. For just $10 a month, you'll unlock a growing vault of extras: bonus episodes, live video replays, special event invites, and an annually updated PDF guide to Paris that's worth its weight in Comté. You can get started in under a minute via Patreon or Substack — and if you're already a member, thank you. You're the reason this exists. More from The Earful Tower: Website · Weekly Newsletter · Walking Tours

Cette semaine on reçoit Patrick Senécal.

Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them.If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you.What's Discussed:03:15 Why supplements are the "Wild West" of holistic health.08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people.15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur.22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation.29:45 Why your meditation practice may be failing because of a supplement.37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery.46:08 The future of multi-omics testing and personalized protocols.Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at younggoose.comInstagram: @young_goose_skincareFind more from Dr. Tyler Panzner:Website: drtylerpanzner.comInstagram: @drtylerpanznerFacebook: Dr. Tyler PanznerLinkedin: Tyler Panzner, Ph.D.YouTube: @drtylerpanznerFREE Guides: drtylerpanzner.com/free-guides1:1 Genetic Coaching: https://drtylerpanzner.com/startyourjourneyQuieting an Overactive Mind Webinar: https://overstimulated.drtylerpanzner.com/webinar-registration-page

Debi Bryk has spent over eight years using functional genomics in clinical practice — and what she found changed everything about how she works with clients. In this conversation, Debi walks through the MaxGen Labs WORX panel, breaks down methylation in plain English, explains why MTHFR is only one piece of a much larger puzzle, and reveals why jumping straight to methylated B vitamins without knowing your COMT status can leave you feeling dramatically worse. She also unpacks how genetic variants in toxic response to plastics, pesticides, and seed oils can explain why some people develop chronic illness in environments that don't seem to affect others — and what you can actually do about it. Debi also explores the emerging role of lithium orotate in ADHD and Alzheimer's prevention, why low choline may be driving the mood and cognitive crisis more people experience every day, and shares her clinical framework for sequencing testing that dramatically accelerated healing and reduced costs for her clients by eliminating the guesswork entirely. Use code BEAUTIFULLYBROKEN for a discount on MaxGen Labs testing at MaxGen Labs.  Episode Highlights  [00:00] Understanding Genetic Variants and Their Impact [09:40] The Power of Genetic Testing [19:21] Methylation and Its Role in Health [29:04] Epigenetics: Environment and Gene Expression [32:17] Understanding B12 Levels and Genetic Implications [33:31] Genetic Risks: Alzheimer's and Toxins [36:33] Precision Medicine and Personal Health [38:21] Neurotransmitter Dynamics and Mental Health [38:52] The Role of MAO and COMT in Neurotransmitter Regulation [43:33] The Impact of Supplements on Mental Health [47:07] Nutritional Insights: Choline and Creatine [48:32] The Importance of Comprehensive Testing [50:09] Future of Peptide Research and Safety Concerns [54:17] Closing Thoughts on Health and Wellness   Upgrade Your Health MaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKEN   Code: BEAUTIFULLYBROKEN LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN StemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52 Code: beautifullybroken     . CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this special replay, BS Free MD host Dr. May Hindmarsh steps out from behind the microphone and into the guest chair. Originally recorded for the Hotflash Inc. podcast with host Anne-Marie McQueen, this candid conversation explores Dr. May's personal journey through menopause, hormone therapy, histamine intolerance, epigenetics, and the unexpected challenges she faced when conventional solutions didn't provide the answers she was seeking. After more than 30 years practicing medicine, Dr. May found herself navigating a complex health journey that included severe hot flashes, migraines, sleep disruption, anxiety, panic attacks, elevated heart rate, and symptoms that persisted despite hormone replacement therapy. As both physician and patient, she began asking deeper questions about genetics, hormone metabolism, mast cell activation, and individualized care. Together, Anne-Marie and Dr. May discuss the importance of critical thinking in medicine, the dangers of one-size-fits-all approaches, and why listening to your own body may be one of the most important skills in healthcare. In This Episode Why Dr. May and Dr. Tim launched BS Free MD Lessons learned from practicing medicine through the COVID era What happened when hormone therapy stopped working as expected Histamine intolerance and mast cell activation explained The role of MTHFR, COMT, and epigenetics in hormone metabolism Why some women thrive on hormone therapy while others struggle Trauma, stress, and their impact on health outcomes The growing movement toward personalized medicine How to navigate conflicting health information Learning to trust your body's signals About Dr. May Hindmarsh Dr. May Hindmarsh is a retired family physician with more than three decades of experience practicing medicine in Canada and the United States. Alongside her husband, Dr. Tim Hindmarsh, she co-hosts BS Free MD, where they challenge conventional narratives, explore emerging health topics, and encourage listeners to think critically about medicine, wellness, and personal responsibility. Original Interview This episode originally aired on the Hotflash Inc. podcast and is being republished on BS Free MD with permission. Connect with BS Free MD Website: https://www.bsfreemd.com Podcast: https://www.bsfreemd.com/podcast YouTube: https://www.youtube.com/@BSFreeMD Disclaimer The information shared in this episode is for educational and informational purposes only and should not be considered medical advice. Always consult your healthcare professional regarding your individual health needs.

Cette semaine on reçoit Daniel Benson. ⚖️

Gère ton immo locatif comme un pro avec Qalimo

Cette semaine on reçoit une véritable légende du Centre Bell :

This episode of the Everyday Epigenetics: Raw. Real. Relatable. podcast takes a hard look at one of the biggest trends in the wellness world: detox culture. Susan Robbins shares a raw and deeply honest perspective on the fear-based messaging surrounding parasites, mold, heavy metals, cleanses, and “toxic overload,” while explaining what true detoxification actually looks like inside the body. From harsh protocols and supplement overload to the nervous system's role in health, this conversation challenges the idea that more detoxing always equals better wellness.Susan also dives into the genetics behind detox pathways, including MTHFR, COMT, PEMT, GST genes, inflammation markers, bile flow, and histamine responses. She explains why personalized health matters, why one-size-fits-all detox programs can backfire, and how stress, sleep, nutrition, circadian rhythm, and emotional safety often play a much bigger role in how the body functions than another cleanse ever will. This episode is a reminder that the body already knows how to detox when it has the right support, nourishment, and stability.In this episode:Why the detox industry often profits from fearThe difference between true toxic overload and depletionHow the body naturally detoxifies through the liver, kidneys, gut, skin, and lymphatic systemWhy harsh cleanses can create more stress on the bodyThe truth about parasite cleanses, binders, colonics, and juice detoxesHow chronic stress impacts detox pathways and hormone balanceWhy genetics like MTHFR, COMT, GST, PEMT, IL6, and TNF-alpha matter in personalized healthThe connection between histamine, sulfur pathways, glutathione, and detox symptomsHow nervous system regulation impacts healing and detoxificationWhy lifestyle rhythms, sleep, meal timing, and stress management matter more than most people realizeHow Susan uses epigenetics and PH360 health types to personalize detox supportThe importance of building resilience instead of living in fear around healthRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/05/18/episode124/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Cette semaine sur le podcast, on sort complètement de notre zone de confort

You've seen this before. A genetic report comes back loaded with red SNPs. MTHFR. APOE. COMT, and suddenly everything feels more complicated. More supplements. More restrictions. More second-guessing.That creates overwhelm.In this episode, Dr. Ritamarie breaks down how to actually use genetics in practice without turning it into a list of problems to fix. SNPs aren't diagnoses, and they don't tell you what to do on their own.What matters is how those variants show up in the body.You'll learn how to step back, look at pathways instead of individual SNPs, and connect genetics with labs, symptoms, and physiology, so your decisions actually make sense.If genetic testing has ever made things harder instead of clearer, this will change how you approach it.What's Inside This Episode?• Why genetic testing often creates overwhelm instead of clarity • The problem with focusing on individual SNPs like MTHFR and APOE • Why SNPs are variants, not diagnoses or mutations • The shift from “red flags” to pathway-based thinking • How to integrate genetics with labs, symptoms, and physiology • What to look at instead of reacting to every variant • How to prioritize interventions using systems thinking • Why sequencing matters more than stacking protocolsResources and Links:Download the full transcript hereDownload our FREE Smart Supplementation MatrixJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out our other podcast episodes here

Cette semaine, on reçoit Denis Bourque pour parler d'un sujet que tout le monde vit… mais que personne comprend vraiment

Why does buying from a good cheese shop often beat picking up a wedge from the supermarket? How do people underestimate the physical labor and other demands of being a cheesemonger? How does using a cheese iron reveal where a wheel of cheese is in its life? In this episode of the Unreserved Wine Talk podcast, I'm chatting with Michael Finnerty, author of the terrific new book The Cheese Cure: How Comté and Camembert Fed My Soul. You can find the wines we discussed at https://www.nataliemaclean.com/winepicks.   Giveaway Three of you are going to win a copy of Michael Finnerty's new book, The Cheese Cure: How Comté and Camembert Fed My Soul. To qualify, all you have to do is email me at natalie@nataliemaclean.com and let me know that you've posted a review of the podcast. I'll choose three people randomly from those who contact me. Good luck!   Highlights Why do so many people underestimate the physical labor and other demands behind life as a cheesemonger? How does using a cheese iron reveal where a wheel is in its life? Why can two wheels of the same Comté taste noticeably different? How do grading systems help protect cheese quality? Why do locally made cheeses sometimes outperform famous imported cheeses? What are the advantages of visiting a cheese shop over supermarkets and bulk retailers? How do cheesemongers tell the difference between a cheese that is flawed and one that is stronger than their taste preferences? What causes washed rind cheeses to develop those famously funky aromas? What made the Hervé Mons 1924 Bleu so unforgettable that Michael describes it as a narcotic cheese? Why should you always taste a cheese before buying it?   About Michael Finnerty Michael Finnerty is a cheesemonger, journalist, and author based in both London, UK, and Montreal. After almost 30 years of success and acclaim working for the CBC, BBC, and The Guardian, he found joy and a new life selling cheese at London's iconic Borough Market. Mike has a weekly column on Pénélope on Radio-Canada, works part-time at Global Montreal, but for most of the year, you can find him slinging cheese with the other mongers. Critically acclaimed, The Cheese Cure is his first book.         To learn more, visit https://www.nataliemaclean.com/388.

Cette semaine, on reçoit Lost pour un nouvel épisode ON THE ROAD!

Why do some wine and cheese pairings taste better together than either one alone? Why do some wines collapse when paired with certain cheeses? What will surprise you about cheese that's similar to wine? In this episode of the Unreserved Wine Talk podcast, I'm chatting with Michael Finnerty, author of the terrific new book The Cheese Cure: How Comté and Camembert Fed My Soul. You can find the wines we discussed at https://www.nataliemaclean.com/winepicks.   Giveaway Three of you are going to win a copy of Michael Finnerty's new book, The Cheese Cure: How Comté and Camembert Fed My Soul. To qualify, all you have to do is email me at natalie@nataliemaclean.com and let me know that you've posted a review of the podcast. I'll choose three people randomly from those who contact me. Good luck!   Highlights Why do some wine and cheese pairings taste better together than alone? Why did a natural red wine collapse when paired with Camembert? How do acidity and bubbles transform rich cheese? How does cheese age differently from wine? Why do tyrosine crystals in aged cheese create both crunch and pleasure? Why can older cheeses develop surprising flavors like rum and raisin rather than simply becoming sharper or saltier? How do cheese appellations work, and why are names like Roquefort or Parmigiano legally tied to place? What is the difference between a cheesemonger and an affineur? How did Michael Finnerty's midlife pivot from journalism to selling cheese begin? Why did selling cheese feel more meaningful to Michael than covering wars, elections, and other major news events? What makes Borough Market special beyond the food itself?   Key Takeaways Why do some wine and cheese pairings taste better together than either one alone? I had tasted a medium bodied wine with some nice minerality that also had some savoury notes and some citrusy notes. When you paired it up with the Ossau-Iraty, which is a higher fat cheese, the two of them paired together, one lifted the other. It was just that perfect example of how when you hit a pairing right, when you're spot on, the wine is improved and the cheese improved. Both are lifted. Why do some wines collapse when paired with certain cheeses? So we were tasting a red, it was bright and fruity. And then we had some Camembert. And Camembert is a big cheese and it's a hard cheese to pair. It's more pungent than Brie. For me, it has a real garlicky side to it. It's always going to depend on where it is on its little journey in life. which is much shorter, obviously, than a bottle of wine's. But when you get a Camembert that starts to get riper, it is going to have a quite a punch and quite a garlicky taste. With this natural red and Camembert, both started to taste not very nice to be honest. What else do you think wine and cheese share that might surprise us? First of all, if people didn't realize that cheeses have appellations as well, which are granted based on applications that are made to a central authority. That comes with what the French call a cahier des charges, so kind of a manual on how to make the cheese. The first one having been in 1925, now there's loads of appellations. And they're not just French cheeses. Of course, things like Parmigiano are appellations as are raclette in Switzerland. You'll get some cheeses that like, for instance, Brie. Those are going to be loads of Brie, but there's only one Brie de Meaux, which is the appellation.   About Michael Finnerty Michael Finnerty is a cheesemonger, journalist, and author based in both London, UK, and Montreal. After almost 30 years of success and acclaim working for the CBC, BBC, and The Guardian, he found joy and a new life selling cheese at London's iconic Borough Market. Mike has a weekly column on Pénélope on Radio-Canada, works part-time at Global Montreal, but for most of the year, you can find him slinging cheese with the other mongers. Critically acclaimed, The Cheese Cure is his first book.       To learn more, visit https://www.nataliemaclean.com/387.

On this episode, we are joined by Jyo Supnekar, an occupational therapist and certified hand therapist who recently traveled to Nepal to share her expertise with therapists and other healthcare workers. Jyo shares with us the work that the mission team did in delivering medical care to patients in the hospital, as well as the education that was provided to local therapists. Jyo Supnekar, OTR/L, OTD, CHT, COMT, CLT is a Clinical Specialist at Johns Hopkins. She graduated in 1986 from the University of Mumbai, India, with a master's in occupational therapy. She has practiced in the United States since 1989 and has worked as a Certified Hand Therapist since 1998. She has a Post Professional Doctorate in Occupational Therapy and a Certification in Orthopedic Manual Therapy- the UE track from IAOM-US. She has an NDT certification for adult hemiplegia, a Lymphedema Certification and a Certificate in Advance Study of Hand and Upper Quarter Rehabilitation from Drexel University. From 2017- 2023, she established and served as the founding director of the hand therapy fellowship at Johns Hopkins. She has been an educator for fieldwork students and hand therapy fellows for numerous years. She has presented numerous times nationally and a few times internationally. She serves as a board member for the AOTA Fellowship Programs Review Committee and is an instructor for the Johns Hopkins School of Medicine.The views and opinions expressed in the Hands in Motion podcast are those of the guests and do not necessarily reflect the official policy or position of ASHT. Appearance on the podcast does not imply endorsement of any products, services or viewpoints discussed.

Episode Show NotesWe've been taught to believe that more exercise equals better health, stronger bodies, and faster results. This episode challenges that belief in a big way. Susan breaks down how pushing harder and training longer can actually backfire, leading to chronic inflammation, disrupted recovery, and even long-term health consequences that often go unnoticed.This conversation goes deeper than surface-level fitness advice. It connects the dots between genetics, lifestyle, and training patterns to show why two people can follow the exact same workout plan and experience completely different outcomes. From inflammatory gene responses to stress hormone regulation and recovery capacity, your body has a unique threshold, and ignoring it can quietly work against you.Susan also walks through how overtraining shows up beneath the surface, even when you feel “fine.” Blood markers, nervous system dysregulation, sleep disruption, and metabolic shifts all play a role in whether your body is adapting or breaking down. The goal isn't to stop moving, it's to train with precision, honoring your body's rhythms, recovery needs, and individual design.By the end of this episode, you'll have a new lens on exercise, one that prioritizes alignment over intensity, and sustainability over burnout. Because real progress doesn't come from doing more. It comes from doing what actually works for your body.In this episode:Why too much exercise can trigger chronic inflammation and slow recoveryHow genetics influence your response to stress, training, and inflammationThe role of stress hormones like cortisol in overtraining and burnoutKey gene variants (like COMT, IL-6, TNF-alpha) and what they mean for your bodyHow different health types respond to exercise, and why personalization mattersThe hidden signs of overtraining, even when you feel “healthy”Blood markers to watch for (fasting insulin, triglycerides, CRP, glucose)How chronobiology (timing) impacts performance and recoveryWhy recovery, not intensity, is where real progress happensHow to train smarter by aligning with your body's natural capacityRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/04/27/episode121/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Depuis que nous avons quitté notre chère Comté, nous avons réalisé qu'il était plus difficile de se nourrir correctement dans la nature. Surtout en matière de gibier.Mais avez-vous déjà songé à arrêter de manger de la viande ? 

Nous sommes à la fin du XIe siècle, un peu avant 1090. C'est à cette époque qu'un ecclésiastique nommé Jocundus passe quelques jours à Maastricht. A la demande des religieux de la région, il rédige une hagiographie, un ouvrage destiné à encenser Saint-Servais, leur patron. Dans son texte, le prêtre mentionne les circonstances de la construction d'un château à Dalhem, dans le pays de Herve. En réalité, une forteresse voulue par le comte palatin Heremannus ou Hermann. Jusque-là, Dalhem était une terre sans importance, située aux confins occidentaux de l'Empire germanique. Mais la donne va changer avec les luttes d'influence auxquelles vont se livrer quelques grands princes : de Namur, du Brabant, de Bouillon, du Limbourg, sans oublier les puissants princes-évêques de Liège, qui cherchent, par tous les moyens, y compris criminels, à affirmer leur hégémonie entre la Meuse et le Rhin. Le comté de Dalhem devient dès lors un carrefour d'ambitions politiques plongeant la région dans des situations kafkaïennes. En route pour un voyage dont le carburant est la soif de pouvoir … Invité : Fabrice Mairlot, ULG. « Le comté et pays de Dalhem : des origines au XXIe siècle », dirigée par Laetizia Puccio. Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Hét miniszterjelölt nevét jelentette be hétfőn Magyar Péter, köztük a külügyért és a gazdaságért felelős tárcavezető nevét is. Vendégeinkkel körbejárjuk, milyen mozgástere lesz a Tisza-kormánynak a külkapcsolatok terén, ebben Bukovics Martin Gemist-alapító és Győri Gábor, a Policy Solutions vezető elemzője lesz a segítségünkre. Vendégünk a DE Akcióközösség két vezetője, Tímár Áron és Kiss Balázs is, őket a szavazatvásárlás akadályozására szervezett választásnapi projektjükről kérdezzük. Pogátsa Zoltán közgazdásszal azt járjuk körül, hogy milyen gazdasági helyzetben kell helytállnia az új kormánynak. Sarkadi Zsolttal, a Partizán egyik szerkesztőjével pedig végignézzük azt is, milyen területek kapnak saját minisztériumot.00:00 Visszaszámláló04:20 A Tisza külpolitikai mozgástere Győri Gáborral és Bukovics Martinnal1:00:13 A szavazatvásárlások visszaszorítása - vendégünk a DE Akcióközösség két vezetője1:38:02 Mit kezd a rossz gazdasági helyzettel a Tisza Párt? - vendégünk Pogátsa Zoltán közgazdász2:12:59 - Mi várható az új miniszterektől? - elemzés Sarkadi Zsolttal, a Partizán szerkesztőjével ‼️Csatlakozz a Partizán következő négy évéhez – támogasd rendszeresen a munkánkat: https://cause.lundadonate.org/partizan/2030Támogasd te is a Partizánt adód 1%-ával!Név: Partizán Rendszerkritikus Tartalomelőállításért AlapítványAdószám: 19286031-2-42https://szja.partizan.hu/Legyél rendszeres támogató! https://cause.lundadonate.org/partizan/adomanyPartizán webshop:https://shop.partizan.hu/—Választási barométer:https://valasztas.partizan.hu/—Csatlakozz a Partizán közösségéhez, értesülj elsőként eseményeinkről, akcióinkról!https://csapat.partizanmedia.hu/forms/maradjunk-kapcsolatban—Legyél önkéntes!Csatlakozz a Partizán önkéntes csapatához:https://csapat.partizanmedia.hu/forms/csatlakozz-te-is-a-partizan-onkenteseihez—Iratkozz fel tematikus hírleveleinkre!Kovalcsik Tamás: Adatpont / Partizán Szerkesztőségi Hírlevélhttps://csapat.partizanmedia.hu/forms/iratkozz-fel-a-partizan-szerkesztoinek-hirlevelereHeti Feledyhttps://csapat.partizanmedia.hu/forms/partizan-heti-feledy—Írj nekünk!Ha van egy sztorid, tipped vagy ötleted:szerkesztoseg@partizan.huBizalmas információ esetén:partizanbudapest@protonmail.comTámogatások, események, webshop, egyéb ügyek:info@partizan.hu

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Sheena: Hi Dr. C! Hope you and your team are well. I'm at 46 yo female in the thick of perimenopause, and suffering from all its symptoms and I also have gut issues too. I'm going to run the Big Five and would also like to run the Menopause and Fertility test as well. My question is, will running the Menopause test be beneficial even though the Big 5 includes the Stress Mood test? I would like as much data as possible because knowledge is power, but also don't want to purchase unnecessary tests. Looking forward for your response!      Anonymous: Have you ever heard of Cantron/Cancel/Protocel? It claims to help with C using bioelectrical wellness. "Stimulate cellular regeneration so body can regenerate/repair more efficiently, by restoring the electrical environment which determines whether cells thrive/die." It has K, NA, Fe, Ca, Cu, sulfur and a blend of phenolic compounds from flavonoid family subgroup catechins, quinones, hydroxyquinones and cyclophentenes. My family knows people that have had success with it. My aunt has triple negative breast cancer despite taking it. She is adiment that she wants to stay on it while working on lifestyle changes. Taking it limits other supplements she can take so I feel stuck in how to help her. Any insight you have would be great!     Alex: Will it boost my metabolism and enable me to enjoy all foods while keeping my weight stable if I do every other day. So one day carbs only next protein only next carbs only next protein only and so on? Thankyou Alex      Anonymous: Is it possible that an inguinal hernia could repair itself without the need for surgery? (Asking for an adult female in case this matters.) What corrective exercises would be recommended, and which exercises should be avoided? How long might this kind of hernia take to repair if it is possible? Thank you!      Patricia: I can't handle any methylated vitamins or quercetin - I react strongly, fatigue, body tingling and aches, migraines. I know the cause - mold, and I'm working on it. However my coach (not an ihp) keeps trying to push methyl's as she says this means I'm methylating poorly. I think this means I can't clear methyl's, not that I don't methylate enough. What do you think? I do have a mthfr variant, not on the primary snp but the other one, and I am a fast COMT. I am trying to figure out how to dial in my b vitamins and how to make sure I don't overdo it. I take all non methyl forms now. This is also keeping me from doing your detox sadly, as the daily nutritional support has methyl's. Any insight or pointers would be appreciated!    Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3726 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women's health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women's longevity today. Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s. You'll Learn: Why vaginal hormone delivery outperforms every other delivery method for women How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear Why a carnivore or animal-based diet raises estrogen and why fiber lowers it How progesterone converts to testosterone in women, and why you may not need a testosterone prescription The real reason SSRIs get prescribed when hormone replacement therapy should come first Why iodine is essential for breast health, estrogen metabolism, and thyroid function How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys Why both partners need hormone replacement therapy for a relationship to thrive How hormones control mitochondria, dopamine, norepinephrine, and every system in your body Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - Igniton | Try risk free at Igniton.com and use code DAVE at checkout for 15% off. Backed by a 30-day money back guarantee. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Sarah Daccarett, Inner Balance, women's hormone therapy, bioidentical hormones, vaginal hormone delivery, estrogen deficiency, progesterone therapy, hormone replacement therapy, perimenopause, testosterone women, COMT genetics, FSH hormone, iodine deficiency, oxalates health, leaky gut hormones, women's longevity, biohacking, Dave Asprey, human performance, functional medicine, anti-aging Resources: • Visit Sarah's Website and use code ‘PODCASTDRSARAH': https://www.innerbalance.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:15 – Introduction 2:43 – The Gender Gap in Hormone Care 5:14 – Why Women's Hormone Therapy Is Stuck in the 1960s 8:09 – Why Young Women Are Losing Their Hormones 9:33 – Toxins, Birth Control & Hormone Disruption 14:07 – How Fiber Steals Your Hormones 19:53 – Hormones, Libido & Brain Chemistry 32:13 – Pills, Patches & Why They Fail 36:54 – Why Vaginal Delivery Works Best 44:36 – Symptoms of Low Hormones 46:07 – Leaky Gut Is a Hormone Problem 47:38 – How Low Hormones Destroy Relationships 52:28 – Thyroid, Iodine & Sex Hormones 1:00:29 – Progesterone for Men 1:05:18 – Oxalates, Kidney Stones & Your Diet 1:11:13 – Where to Find Dr. Sarah See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Abondance cheese — one of the great forgotten Alpine cheeses of France — has a story that stretches back to the medieval monasteries of Haute-Savoie and all the way to the papal conclave in Avignon in the fourteenth century, where it was served to cardinals from across Europe. In this episode of Fabulously Delicious, we're telling the full story of Abondance cheese — the semi-hard, raw cow's milk Alpine cheese from the Abondance Valley in Haute-Savoie that most people have never heard of, and that deserves to be mentioned in the same breath as Comté and Beaufort.The story of Abondance cheese begins with the Cistercian monks of the Abbaye d'Abondance in the French Alps, who began making this extraordinary Alpine cheese in the Middle Ages as a way of preserving milk through long mountain winters. The cheese they developed was so remarkable that by the fourteenth century it was travelling far beyond the valley — all the way to the papal conclave in Avignon, where it was served to the highest ranks of medieval European society. A tiny Alpine valley sending its cheese to the cardinals of Europe. Which tells you everything about the quality of what the monks had created.The Abondance Valley in Haute-Savoie is one of the most beautiful corners of the French Alps — dramatic peaks, wooden chalets, flower-rich mountain pastures near the Swiss border. And at the heart of it all is the Abondance cow — the chestnut and white breed perfectly adapted to mountain life, producing milk rich in protein and fat that gives Abondance cheese its distinctive fruity, nutty, buttery character. The cheese received its AOC status in 1990 and its AOP in the years that followed, protecting everything from the milk to the shape of the wheel — and ensuring that one of France's great Alpine cheeses remains exactly what it has always been.Abondance cheese melts beautifully — perfect in fondue, gratins and Alpine dishes — and is at its absolute best between June and December when the cows have been grazing high in the mountains and the milk is at its most aromatic. It's the kind of cheese that makes you wonder why it isn't as famous as its Alpine neighbours. After this episode, you'll understand exactly why it deserves your attention.Send us Fan MailSupport the showMy book Paris: A Fabulous Food Guide to the World's Most Delicious City is your ultimate companion. This is a new 2026 update for the book and you'll find hand-picked recommendations for the best boulangeries, patisseries, wine bars, cafés, and restaurants that truly capture the flavor of Paris. You can order it online at andrewpriorfabulously.com For those who want to take things further, why not come cook with me here in Montmorillon, in the heart of France's Vienne region? Combine hands-on French cooking classes with exploring charming markets, tasting regional specialties, and soaking up the slow, beautiful pace of French countryside life. Find all the details at andrewpriorfabulously.comYou can help keep the show thriving by becoming a paid subscriber on substack where you'll also get fabulous extra content. Every contribution makes a huge difference. Join here at Substack , Merci beaucoup!Newsletter Youtube Instagram Facebook ...

WATCH THE EPISODE HEREIn this EpisodeHighlights & “Must-Listen” Moments* 0:00 — Welcome to the live, and a tech hiccup: We start strong (one minute early!) before Amy promptly drops off the call. Welcome to live television, folks.* 2:22 — Big announcement — we're moving to Wednesdays at noon ET: David (Fatty Daddy) is almost 66 and exhausted by late-night shows. Starting next week, Talking with My Mouth Full goes live every Wednesday at 12 noon Eastern. West Coasters, that's 9 a.m. Europeans, we see you, too.* 6:20 — Amy's sourdough report: The Miche: Amy's been baking her way through the King Arthur Big Book of Bread, and this week's loaf was a miche — a classic French whole-grain sourdough, deeply tangy, chewy, and wonderfully moisture-retaining. Her starter is named Lazarus (given to her by a pastry chef at The Alna Store in Maine), and the name fits.* 10:28 — David's food week: Lasagna Bianca and the Coca-Cola Brisket Aftermath: David finally had all the right cheeses (ordered from Caputo's) for his five-cheese lasagna bianca, with handmade noodles rolled to setting 6 or 7 — so thin you can see through them. (Marcella Hazan once wrote him to say that's exactly how it should be done.) He also confesses to eating an entire five-pound Coca-Cola brisket over the course of several days. No regrets.* 10:45 — The L. Reuteri Yogurt Rabbit Hole: Amy has gotten into making homemade yogurt using Lactobacillus reuteri, a culture promoted by Dr. William Davis (Wheat Belly) for its alleged gut-health and serotonin-boosting effects. The evidence: her sister-in-law went from tightly wound to noticeably chill. It's made with half-and-half and is genuinely delicious. Amy's verdict: she may have a delightful personality again.* 15:30 — ADHD confessions: David opens up about struggling to function without The One around — 269 unpublished posts sitting in his website backend, four photos from a shoot last June never uploaded, six holiday videos still in draft. Amy relates: She says she's somewhere on the spectrum, and got into a fight with Scott when she started raking leaves at 1 p.m. for a 2 p.m. departure. (She was ready by 2:05, for the record.) Audience members chimed in to share their own experiences.* 22:10 — Books We Love: Morning Baker by Roxana Jullapat: David shares his excitement about this upcoming baking book (drops April 7th), packed with gorgeous recipes from the author of Mother Grains. Donuts, French toast, and beautiful photography — this one earned a “must have the physical copy.”* 24:46 — Amy's Pick: A Kitchen on Goose Cove by Devin Finigan: Amy recommends this forthcoming cookbook from the chef of Aragosta restaurant in Maine, arriving later in April. The restaurant sits at the edge of an enchanted-forest cove overlooking the bay — and the food is just as stunning.* 27:18 — Amy's current read: Le Road Trip by Vivian Swift: A beautifully illustrated chronicle of a honeymoon road trip through France, with sections on Bordeaux's food and wine scene. Swift is an illustrator and writer, and Amy is captivated by the humanity of the hand-drawn work — especially in an AI-saturated moment.* 29:56 — Dorie's Anytime Cakes and the illustrated cookbook debate: David and Amy discuss the reactions to Dorie's latest book, which uses a photorealistic illustration style. Beautiful graphic design, but some readers found it less effective than photographs. The conversation leads to a broader point: in the age of AI perfection, people are gravitating toward the human, the imperfect, the messy, and real.* 33:20 — Product Spotlight: The Rose Levy Beranbaum Reduction Spatula: David finally retrieved it from the kitchen. It's a ThermoWorks product from her Signature Series — a long spatula with raised measurement markings so you can track a sauce as it reduces right in the pan, no pouring into a measuring cup required. You can also use it to check viscosity. David has been trying to show it on the show for three weeks. Worth every penny.* 35:46 — Also worth having: Lucinda Scala Quinn's Spurtles: Amy sings the praises of her spurtles — a cross between a spoon and a spatula, available in solid and slotted versions. Great for flipping pancakes, stirring risotto, and pretty much everything else. A quiet classic.* 37:09 — Food News: The 100-Year Oyster Promise Fulfilled: Wintzell's Oyster House in Mobile, Alabama, had a long-standing promotion: free oysters to any man 80 years old, accompanied by his father. In early 2026, 99-year-old James Rush finally walked in with his 80-year-old son Jimmy to claim it. This is the first time in nearly 100 years the promotion has been fulfilled.* 39:13 — The World's Best Cheese: The World Championship Cheese Contest recently crowned the Beemster Royaal Grand Cru — a 12-month-aged Gouda made by a cheesemaker with a Royal Warrant from the Netherlands — as best in show. The cows graze on seagrass near the ocean; the resulting milk delivers butterscotch and toasted almond notes. It is available at specialty cheese shops in the U.S.* 41:03 — Amy's personal favorite: Abbaye de Belloc: A butterscotch-nutty, alpine-style cheese from the Pyrénées in the Comté family, made by affineur Mons and sold at Formaggio Kitchen in Cambridge (which has an in-store aging cave and an online shop).* 43:07 — A love letter to Queijo Serra da Estrela: David raves about Portugal's greatest cheese — an oozy, thistle-rennet sheep's milk cheese from the Serra da Estrela mountains. He recalls a peak life moment at Quinta do Crasto in the Douro, when a nearly empty wheel arrived at the table, spaghetti swirled in the gooey inside with just black pepper. Nearly impossible to find properly aged in the U.S.* 48:35 — So long, and see you Wednesday at noon: Thank you for joining us. The Prosecco is gone, Amy is laughing, and we'll see you next Wednesday at 12 noon Eastern.Products We Love* Rose Levy Beranbaum's Reduction Spatula (ThermoWorks Signature Series) — A long spatula with raised measurement markings for tracking sauce reductions right in the pan. Also useful for checking viscosity. An absolute game-changer for anyone who reduces stocks, sauces, or caramels.* Lucinda Scala Quinn's Spurtles — A cross between a spoon and a spatula, available in solid and slotted versions. Great for stirring, flipping, and doing basically everything at the stove.Books and Publications* Morning Baker by Roxana Jullapat — A baking book dropping April 7th, from the author of Mother Grains* A Kitchen on Goose Cove by Devin Finigan — From the chef of Aragosta restaurant in Maine; coming May 19, 2026.* Le Road Trip by Vivian Swift — Illustrated travel memoir covering a honeymoon journey through France* Dorie's Anytime Cakes by Dorie Greenspan — Out now; photo-realistic illustration style sparked a lively debate* Wheat Belly by Dr. William Davis — The classic tome on eliminating wheat from your diet and whyRecipes* Sourdough Miche (French whole-grain sourdough)* Porridge Bread* L. Reuteri Yogurt (made with half-and-half)* Lasagna Bianca with Five Cheeses (with handmade pasta)* Coca-Cola Brisket* Pastéis de Nata (Portuguese Custard Tarts)Where to Find Us* Amy Traverso* Instagram | Yankee* David Leite* Leite's Culinaria | Instagram | Pinterest | Facebook | YouTubeChow,David This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit davidleite.substack.com

Comment deux enfants peuvent-ils s'évaporer d'un jardin en moins d'une heure ?

#215: Your brain isn't a character flaw, and “lazy” is not a medical explanation. We're pulling on a thread that a lot of people feel but rarely get clarity on: why your life can look like ADHD on the outside while the root cause might be dopamine signaling, sleep debt, stress overload, thyroid function, or shifting hormones.I share what I learned from my own pharmacogenomic genetic testing and how to read the results without spiraling. We talk through key genes that show up in dopamine and mood conversations, including COMT (dopamine breakdown speed), ABCB1 (blood brain barrier transport and medication sensitivity), DRD2 (dopamine receptors), BDNF (neuroplasticity and learning), and the endlessly discussed MTHFR methylation pathway. The point isn't to self-diagnose from a report, but to understand why focus can be effortless in high-interest moments and impossible when something is boring or draining.Then we bring it back to what you can actually do this week: sleep support, morning sunlight, exercise, enough protein, novelty, and real social connection, plus a reality check that thyroid health and hormones can strongly shape brain chemistry. If you've been questioning whether it's ADHD vs low dopamine, this will give you a clearer framework and a lot more self-compassion. Subscribe, share this with a friend who's been stuck in self-blame, and leave a review then tell me: what part of your motivation pattern finally makes sense?You can now send us a text to ask a question or review the show. We would love to hear from you! Support the showFollow me on social: https://www.instagram.com/babbles_nonsense/

It's important for NFTP to share the struggles of the past few months as Bobby and Riann are figuring out how to navigate the challenges of life post prison. There's doing what's best for Cassius, multiple gerbils, toddlers, hitching wagons, crying in the shower, and most importantly pushing through. You can read more about Bobby and prison reform on our website:   notesfromthepen.comT-shirts B.L.A.C.K. Label Art   https://blacklabelart.shop/YouTube: https://www.youtube.com/@notesfromthepen9604Instagram: https://www.instagram.com/p/CJYuOh4pKxa/?igshid=y8lo9kbdifvq   TikTok: https://www.tiktok.com/@bobbyb.l.a.c.k1X: https://twitter.com/NotesFromThePenBluesky: https://bsky.app/profile/notesfromthepen.bsky.socialShout-out to JD and Ashely Bell for all their behind the scenes support.Intro and Outro music created just for Notes From The Pen by PJ Trofibio and Jeff Quintero and used with permission.

Nous sommes à la fin du XIe siècle, un peu avant 1090. C'est à cette époque qu'un ecclésiastique nommé Jocundus passe quelques jours à Maastricht. A la demande des religieux de la région, il rédige une hagiographie, un ouvrage destiné à encenser Saint-Servais, leur patron. Dans son texte, le prêtre mentionne les circonstances de la construction d'un château à Dalhem, dans le pays de Herve. En réalité, une forteresse voulue par le comte palatin Heremannus ou Hermann. Jusque-là, Dalhem était une terre sans importance, située aux confins occidentaux de l'Empire germanique. Mais la donne va changer avec les luttes d'influence auxquelles vont se livrer quelques grands princes : de Namur, du Brabant, de Bouillon, du Limbourg, sans oublier les puissants princes-évêques de Liège, qui cherchent, par tous les moyens, y compris criminels, à affirmer leur hégémonie entre la Meuse et le Rhin. Le comté de Dalhem devient dès lors un carrefour d'ambitions politiques plongeant la région dans des situations kafkaïennes. En route pour un voyage dont le carburant est la soif de pouvoir … Invité : Fabrice Mairlot, ULG. « Le comté et pays de Dalhem : des origines au XXIe siècle », dirigée par Laetizia Puccio. Merci pour votre écoute Un Jour dans l'Histoire, c'est également en direct tous les jours de la semaine de 13h15 à 14h30 sur www.rtbf.be/lapremiere Retrouvez tous les épisodes d'Un Jour dans l'Histoire sur notre plateforme Auvio.be :https://auvio.rtbf.be/emission/5936 Intéressés par l'histoire ? Vous pourriez également aimer nos autres podcasts : L'Histoire Continue: https://audmns.com/kSbpELwL'heure H : https://audmns.com/YagLLiKEt sa version à écouter en famille : La Mini Heure H https://audmns.com/YagLLiKAinsi que nos séries historiques :Chili, le Pays de mes Histoires : https://audmns.com/XHbnevhD-Day : https://audmns.com/JWRdPYIJoséphine Baker : https://audmns.com/wCfhoEwLa folle histoire de l'aviation : https://audmns.com/xAWjyWCLes Jeux Olympiques, l'étonnant miroir de notre Histoire : https://audmns.com/ZEIihzZMarguerite, la Voix d'une Résistante : https://audmns.com/zFDehnENapoléon, le crépuscule de l'Aigle : https://audmns.com/DcdnIUnUn Jour dans le Sport : https://audmns.com/xXlkHMHSous le sable des Pyramides : https://audmns.com/rXfVppvN'oubliez pas de vous y abonner pour ne rien manquer.Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

In this week's episode of FOX Rehabilitation's Live Better Longer podcast, FOX Regional Director John Dominski, PT, DPT, OCS, COMT, joins the conversation to explore the future of healthcare and the evolving role of physical therapists, occupational therapists, and speech-language pathologists. John shares why the profession must continue shifting from reactive care to proactive, preventative models—and how PTs can function as primary care providers of functional health. He paints a vision of a system that fully integrates PTAs, COTAs, and fitness specialists to support patients across the lifespan. The discussion unpacks the idea of “flipping the funnel,” emphasizing early intervention over downstream treatment. John also speaks directly to students and clinicians on preparing for this shift, changing long‑held mindsets, and advocating for the value of PT amid ongoing Medicare cuts.

In this week's episode of FOX Rehabilitation's Live Better Longer podcast, FOX Regional Director John Dominski, PT, DPT, OCS, COMT, joins the conversation to explore the future of healthcare and the evolving role of physical therapists, occupational therapists, and speech-language pathologists. John shares why the profession must continue shifting from reactive care to proactive, preventative models—and how PTs can function as primary care providers of functional health. He paints a vision of a system that fully integrates PTAs, COTAs, and fitness specialists to support patients across the lifespan. The discussion unpacks the idea of “flipping the funnel,” emphasizing early intervention over downstream treatment. John also speaks directly to students and clinicians on preparing for this shift, changing long‑held mindsets, and advocating for the value of PT amid ongoing Medicare cuts.

In this week's episode of FOX Rehabilitation's Live Better Longer podcast, FOX Regional Director John Dominski, PT, DPT, OCS, COMT, joins the conversation to explore the future of healthcare and the evolving role of physical therapists, occupational therapists, and speech-language pathologists. John shares why the profession must continue shifting from reactive care to proactive, preventative models—and how PTs can function as primary care providers of functional health. He paints a vision of a system that fully integrates PTAs, COTAs, and fitness specialists to support patients across the lifespan. The discussion unpacks the idea of “flipping the funnel,” emphasizing early intervention over downstream treatment. John also speaks directly to students and clinicians on preparing for this shift, changing long‑held mindsets, and advocating for the value of PT amid ongoing Medicare cuts.

he Timberwolves have Jaden McDaniels, Julius Randle and Anthony Edwards. We'd argue that one of the Wolves players is more important than most. On today's show @skoogcole & @adukeMN break down these topics below.- Mike Conley's return - The game last night. Loss against Philly- Rudy's impact- A Timberwolves trade this summerMore Episodes Weekly on all of your listening platforms.FIND OUR SOCIALS BELOW:Instagram: the_daily_wolvesTik Tok: thedailywolvesX: TheDailyWolvesThreads: the_daily_wolvesYoutube: The_Daily_WolvesADVERTISE WITH US: contact wolvesbig3@gmail.comT

There is a foundational skillset essential to occupational therapy that often isn't covered in school: The ability to design a 60-minute session that is both clinically transformative and operationally sound.Bridging the gap between high-level evidence-like task-specific practice for stroke recovery-and the realities of billing codes and patient engagement is no small feat. It is this specific ability to structure "best practice" into a seamless, hour-long experience that separates the master clinician from the novice.In this 1 hour course, we sit down with Rachel Egan, OTR/L, CHT, COMT, a master clinician and rehab manager who understands this complexity firsthand. As an operational leader at NovaCare overseeing 13 clinics, Rachel balances the dual demands of high-quality patient care and administrative excellence.You'll leave this course ready to plan great OT sessions of your own.See full course details here:https://otpotential.com/ceu-podcast-courses/how-to-plan-a-great-ot-sessionSee all OT CEU courses here:https://otpotential.com/ceu-podcast-coursesCheck our our live webinar schedule here: https://otpotential.com/live-ot-ceu-webinarsSupport the show by using the OTPOTENTIAL Medbridge Code:https://otpotential.com/blog/promo-code-for-medbridgeTry 2 free OT Potential courses here:https://otpotential.com/free-ot-ceusSupport the show

Dr. Will Cole and Dr. Tara Swart Bieber join me at The Wellness Oasis during Miami Art Week to reveal why low-level chronic stress destroys longevity faster than anything else, how that COMT gene mutation in half this audience keeps your mind racing when your body needs rest, and why I schedule my entire life around sleep and exercise instead of fitting wellness into leftover time slots. Connect with Dr. Will Cole Website: ⁠https://bit.ly/3LEmCqB⁠  YouTube:⁠https://bit.ly/3LhijSd⁠  Instagram: ⁠https://bit.ly/4qnE2XN⁠  Facebook: ⁠https://bit.ly/49Xe6wg⁠  X.com: ⁠https://bit.ly/4qxNpnN⁠  LinkedIn: ⁠https://bit.ly/49TEEyq⁠  Connect with Dr. Tara Swart Bieber Website: ⁠https://bit.ly/4pJiO5s⁠  Instagram: ⁠https://bit.ly/3YGWDBR⁠  TikTok: ⁠https://bit.ly/4pBD8FN⁠  Facebook: ⁠https://bit.ly/3YCiri9⁠  X.com: ⁠https://bit.ly/4qnYJTz⁠  LinkedIn: ⁠https://bit.ly/4pGzrib⁠  Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/4hMNdgg⁠ BODYHEALTH: “ULTIMATE20” FOR 20% OFF: ⁠http://bit.ly/4e5IjsV⁠ BAJA GOLD: "ULTIMATE10" FOR 10% OFF: ⁠https://bit.ly/3WSBqUa⁠ SNOOZE: LET'S GET TO SLEEP!: ⁠https://bit.ly/4pt1T6V⁠ COLD LIFE: THE ULTIMATE HUMAN PLUNGE: ⁠https://bit.ly/4eULUKp⁠ WHOOP: JOIN AND GET 1 FREE MONTH!: ⁠https://bit.ly/3VQ0nzW⁠ AION: “ULTIMATE10” FOR 10% OFF: ⁠https://bit.ly/4h6KHAD⁠ A-GAME: “ULTIMATE15” FOR 15% OFF: ⁠http://bit.ly/4kek1ij⁠ PEPTUAL: “TUH10” FOR 10% OFF: ⁠https://bit.ly/4mKxgcn⁠ CARAWAY: “ULTIMATE” FOR 10% OFF: ⁠https://bit.ly/3Q1VmkC⁠ HEALF: 10% OFF YOUR ORDER: ⁠https://bit.ly/41HJg6S⁠ RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: ⁠https://bit.ly/44fFza0⁠ GOPUFF: GET YOUR FAVORITE SNACK!: ⁠https://bit.ly/4obIFDC⁠ GENETIC METHYLATION TEST (UK ONLY): ⁠https://bit.ly/48QJJrk⁠ GENETIC TEST (USA ONLY): ⁠⁠https://bit.ly/3Yg1Uk9⁠ Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠ Podcasts: ⁠https://bit.ly/3RQftU0⁠ Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠ TikTok: ⁠https://bit.ly/4coJ8fo⁠ X: ⁠https://bit.ly/3Opc8tf⁠ Facebook: ⁠https://bit.ly/464VA1H⁠ LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠ Website: ⁠https://bit.ly/4eLDbdU⁠ Merch: ⁠https://bit.ly/4aBpOM1⁠ Newsletter: ⁠https://bit.ly/47ejrws⁠ Ask Gary: ⁠https://bit.ly/3PEAJuG⁠ Timestamps 00:00 Intro of Show 03:11 Sleep as Our Human Superpower 06:12 Metrics for Sustainable Wellness 09:15 Thoughts and Trauma Impacting Health 11:56 Misconceptions on Biohacking 17:51 Link between Emotional Stress and Inflammation 24:02 Neuroplasticity as a Foundation of our Well-Being 28:47 Whole Health: Thriving vs. Maintaining 37:03 Women and Autoimmune Disease 42:14 Wearable Technology for Health Metrics 43:31 Good Sleep Hygiene Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Are you a Comté connoisseur or does your heart belong to Rogue River Blue? Can you tell your Brie from your Camembert? Can you name an award-winning Indian cheese and would you recognise a cheese iron? If you take your cheese seriously then One Cheese to Rule Them All: In Search of the World's 100 Best Cheeses (Murdoch Books, 2025) is the companion you need to live your best cheese life. World Cheese Awards judges Patrick McGuigan and Carlos Yescas have a wealth of knowledge garnered from years of travelling and tasting. One Cheese to Rule Them All is a distillation of that experience through 100 cheese profiles that have won awards over the years, offering charming geekery against a backdrop of the people, places and history that define these world-class cheeses. You'll learn how cheese is made, what to drink with each cheese, its World Cheese Awards status, its texture and taste, and lots more to help you choose your cheese more wisely and enjoy it even more. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Are you a Comté connoisseur or does your heart belong to Rogue River Blue? Can you tell your Brie from your Camembert? Can you name an award-winning Indian cheese and would you recognise a cheese iron? If you take your cheese seriously then One Cheese to Rule Them All: In Search of the World's 100 Best Cheeses (Murdoch Books, 2025) is the companion you need to live your best cheese life. World Cheese Awards judges Patrick McGuigan and Carlos Yescas have a wealth of knowledge garnered from years of travelling and tasting. One Cheese to Rule Them All is a distillation of that experience through 100 cheese profiles that have won awards over the years, offering charming geekery against a backdrop of the people, places and history that define these world-class cheeses. You'll learn how cheese is made, what to drink with each cheese, its World Cheese Awards status, its texture and taste, and lots more to help you choose your cheese more wisely and enjoy it even more. This interview was conducted by Dr. Miranda Melcher whose book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. You can find Miranda's interviews on New Books with Miranda Melcher, wherever you get your podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/food

Guest: Dr. Hannah Lawler, Naturopathic Doctor (ND)Core Theme: Moving beyond the "pill for every ill" mentality to embrace nutrition (The Bean Protocol™), individualized hormone support, and the powerful signaling of the female cycle.Key Takeaways & Highlights1. The Luteal Phase "Truth Serum"Uni and Hannah discuss the emotional intensity often dismissed as "just PMS."The Luteal Narrative: The luteal phase (the week before your period) acts as a "BS filter." While it can feel like "lunacy," it often highlights real issues in life or relationships that we suppress during the rest of the month.Actionable Advice: Don't make life-altering decisions (like divorce) during this phase, but document the feelings. Use them as data points to address once your hormones settle.2. Naturopathic vs. Conventional MedicineDr. Lawler clarifies the rigorous path of an ND:Training: Four years of medical school, including biochemistry, anatomy, and pharmaceuticals, plus extensive training in nutrition, homeopathy, and hydrotherapy.The "Village Doctor" Approach: Hannah operates a concierge practice, making house calls. This allows her to see a patient's environment—poking around the pantry to see what they think is healthy versus what actually supports their biology.3. The Foundation of Nutrition: The Bean ProtocolBoth Unique and Hannah emphasize that nutrition is not a "fad" but the literal building blocks of cells.Soluble Fiber (Beans & Psyllium): Essential for clearing recycled estrogen and toxins from the liver. This is the "insurance policy" for anyone on Hormone Replacement Therapy (HRT).Personal Responsibility: You cannot drive a "Ferrari" (your body) and put in the cheapest fuel. High-performance health requires high-quality, consistent inputs.4. Advanced Optimizations: Peptides & GeneticsWhen the foundation of nutrition is set, Dr. Lawler looks at "levers" to move the needle:Peptides: Signaling molecules that tell cells to perform specific tasks (e.g., recovery, skin health, or mood). Hannah highlights GHK-Cu (copper peptide) for anti-aging and Thymosin Beta-4 for recovery.Genetics (3x4 Genetics): Understanding "bottlenecks," such as the COMT gene, which affects how you process caffeine and adrenaline. Knowing your genetics removes the "DIY" guesswork from health.5. Thyroid Health & The "Canary in the Coal Mine"The discussion touches on why Hashimoto's is so prevalent today:Environmental Toxins: Halogens like fluoride, chlorine, and bromine can "plug" iodine receptors in the thyroid, leading to dysfunction.Root Cause: It's never "just" the thyroid; it's a response to stress, viruses, or environmental toxicity (like mold).

On this episode of Vitality Radio, Jared is joined by his wife Jen to explore how folic acid, a synthetic B vitamin, is affecting our health - and the role of genetics in it all. What began as a simple dietary change unexpectedly revealed how folic acid in fortified foods, different forms of B vitamins, and individual genetics can significantly influence mood, energy, and mental clarity. Jared and Jen share their personal experience removing folic acid, adjusting B12 forms, and learning why some people thrive on methylated B vitamins while others feel worse. You'll learn the key differences between folic acid and folate, why more supplementation isn't always better, how B12 forms like methylcobalamin, hydroxocobalamin, and adenosylcobalamin behave differently in the body, and why B6, B12, and folate must work together as a team. This episode provides a practical framework for understanding why “doing everything right” doesn't always lead to optimal results—and how thoughtful experimentation, label reading, and food quality make a meaningful difference.B Vitamin Products DiscussedAdditional Information:Episode #601 Blog Post#505: Emotional Vitality: Jen's Story Part 5 - The Impact of Diet on Mental Health and Physical PainCheck out all five“Jen's Story” Episodes!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

La dernière fois, avec Pierre, il vous parlait des façades comme de la peau vivante de nos bâtiments. Mais cet épisode, on lève les yeux, direction : le toit !Dans ce replay élixir de ce qui se passe aux rencards du beau, ce rendez-vous professionnel inédit corrodait avec Plendi by Vinci Construction, on embarque pour un voyage qui va des maisons vikings du Labrador aux terrasses futuristes de Bâle, en passant par les douces collines du Comté des Hobbits. On y découvre que la végétalisation des toits est bien plus qu'une simple tendance écolo : c'est une solution low-tech, éprouvée par l'histoire, qui répond à une multitude de crises modernes.Vous apprendrez comment un toit qui accueille le vivant peut :Faire chuter de 30% la climatisation d'un immeuble en été.Transformer les toits de Paris en jardin nourricier, augmentant significativement la résilience alimentaire de la ville.Capturer les particules fines, adoucir le vacarme des avions et faire revenir les oiseaux.Doubler la durée de vie de l'étanchéité d'un bâtiment, protégée des UV.Augmenter la productivité au travail de 15%, simplement en offrant une vue apaisante.On y parle poids des structures, législation visionnaire (comme à Bâle), de bactéries du bonheur dans la terre mais aussi du chant des oiseaux comme anxiolytique naturel.Très belle écoute !!===PLENDI by Vinci Construction est une entreprise générale spécialisée dans les projets très haut de gamme : les palaces parisiens BVLGARI, Mandarin Oriental ou George V, les boutiques telles que Cartier ou Dior et, bien sûr, du résidentiel privé…La raison d'être de ce rendez-vous : Nous n'avons plus besoin de nouvelles données sur l'état de la planète pour savoir que le domaine de la construction, de l'architecture et de l'architecture d'intérieur est appelé à s'adapter.Désormais la question, c'est : où est-ce qu'on peut atterrir ? Qu'est-ce qu'on fait ?Depuis 2022, 14 Rencards du beau ont été organisés et ont permis de réunir plus de 300 professionnels du luxe qui souhaitent réfléchir sur comment faire mieux demain.LRDB, c'est faire naître l'envie de faire un peu moins mal que le secteur.Il s'agit de matinées confidentielles dédiées aux architectes et aux acteurs du bâtiment, où nous écoutons des pionniers d'un beau qui questionne le monde et inspire.Chaque session accueille 2 intervenants :Un acteur hors champ de l'architecture et du design, mais qui vient justement nous nourrir avec ses ailleurs.Un acteur du sérail, que je sélectionne pour son engagement, sa vision, son travail.===Rejoins le SOCIAL CLUB Où est le beau ? en t'abonnant ici : https://buy.stripe.com/14k4gi5JQ6AQaMofTu auras ainsi accès :-à tous les longues interviews en preview (48h avant) et en intégralité -à tous les épisodes avec une clé = le podcast secret (environ 40 épisodes narratifs) pour découvrir comment vivre un quotidien plus aligné avec les valences hautes du beau et du bon-aux 2 newsletters mensuelles dans lesquelles j'ouvre mon jardin secret et partage mes découvertes les plus pépites (hôtels, restaurants, artistes, créatifs, producteurs etc).Tu peux aussi t'abonner uniquement à la newsletter Où est le beau : https://ouestlebeau.kessel.media/?source_referral=None&source_type=user_referralet à celle Où est le bon :https://httpshttpsouestlebeaukesselmediakesselmedia.kessel.media/?source_referral=None&source_type=user_referral&utm_medium=email&utm_source=subscribe_linkA très vite sur les ondes !HélèneHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

On this episode, Jared and Jen break down one of the most misunderstood hormone issues affecting both women and men: estrogen dominance. This isn't always about having “too much estrogen”—it's about a ratio problem, driven largely by low or depleted progesterone. You'll learn how estrogen is metabolized through different liver pathways, why some forms of estrogen are far more disruptive than others, and how liver health, gut function, stress, blood sugar, and environmental exposures all shape hormone balance. The episode also explores how estrogen dominance shows up differently in women and men, why symptoms often persist even when labs look “normal,” and how modern lifestyle factors quietly stack the deck against hormonal health.Jared and Jen also take an honest look at hormonal birth control, endocrine disruptors, seed oils, and genetic factors that can impair estrogen clearance—without fear-mongering or oversimplification. The episode closes with a clear, practical framework for supporting estrogen metabolism, restoring progesterone balance, and addressing the root causes naturally.Products:LiverVitalityEndoCleanseBack on TractVital D3/K2Ultimate Vitality MultiActive B ComplexMagnesium BisglycinateAdditional Information:#588: The Hidden Epidemic Part 1: How Endocrine Disruptors Are Hijacking Your Health#589: The Hidden Epidemic Part 2: The Complete Endocrine Detox Strategy#595: The Estrobolome Explained: How Your Gut Shapes Your HormonesCheck out all five“Jen's Story” Episodes!Dirty Genes - Book by Dr. Ben LynchVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Nutritionist Leyla Muedin details key aspects of supplement use and addresses frequently asked questions. Topics include the importance of targeted supplementation, the rationale behind personalized dosages, best practices for starting new supplements, and managing common issues like nausea and bright yellow urine. Leyla also explains why some supplements may cause gastrointestinal discomfort and provides guidance on how to adjust dosages for optimal results. Emphasis is placed on the benefits of pharmaceutical-grade supplements available on Fullscript and the necessity of regular blood tests to fine-tune supplementation.

Welcome to DipShips, the "Legitimate" Boating Podcast! On this weeks episode, the crew talks about take 2'n it, eugenic big naturals, Good Job, Jamie, It's not Starscream, Eri's Math Lesson, RIP DougEpisodes, Caucasian or Undecided, Comt the SuperHorse, Carl and Marsh Go To A Regional, Nick's Bad Movie Beatdown, just -lette, The Killdozer, PEAK gaming, fictional character Steve Harvey, and drifting aircraft carriers. DipShips is a totally Legitimate Boating Podcast hosted by some friends who love to talk facts about boats after retelling the events of their weeks, sharing a few stories, and answering some questions. Check out Ben's Odyssey and Patchwork's other games with our Creator Bundle: https://itch.io/s/147040/calamity-carl-creator-support-bundle?c=calamitycarl Check out our stuff: ►Patreon: https://www.patreon.com/m/DipShipsPod ►Podbean and other podcast apps: https://dipships.podbean.com/ ►Merch: https://streamlabs.com/thecalamitycarl/merch ►Send Questions and Topics to Questions@DipShips.Boats ►Podcast Twitter: https://twitter.com/DipShipsPod ►BlueSky: https://bsky.app/profile/dipships.boats ►TikTok: https://www.tiktok.com/@dipshipspod The DipShips Crew: ►Carl: https://bsky.app/profile/calamitycarl.com ►PM: https://bsky.app/profile/pappums.bsky.social ►Metty: https://bsky.app/profile/metty.bsky.social ►Nick: https://bsky.app/profile/xerinos.bsky.social Special Thanks: ►Edited by Mimi: https://bsky.app/profile/social.mimickrii.com ►Intro and additional music by Vidazen: https://bsky.app/profile/vidazen.bsky.social ►Logo by ShibuyaGato: https://bsky.app/profile/shibuyagato.bsky.social ►Art assets by Shorah: https://bsky.app/profile/shorah.bsky.social 

How mindset, hunger management, and practical tools can make fasting easier and more sustainable. Episode #235

"Vegetarian in Paris with Amber Haggerty" is your ultimate guide to eating meat-free in the City of Light—and trust me, it's easier (and tastier) than you think! In this episode of Join Us in France, host Annie Sargent chats with Amber Haggerty, the expert behind The Vegetarian in Paris blog, about where to find the best plant-based meals in Paris. Whether you're a lifelong vegetarian, a curious foodie, or just looking to explore meat-free options, Amber shares her insider tips for navigating Parisian menus, avoiding tourist traps, and discovering hidden gems that even locals love. Listen to this episode ad-free Amber, a long-time vegetarian and Paris resident, reveals her favorite spots for everything from savory Breton galettes at Breizh Café to upscale vegetarian dining at Pristine, where the mushroom tart is legendary. She also highlights cozy wine bars like Le 1745, where you can build your own cheese board, and tiny bakeries like Le Comptoir de la Madeleine, famous for its warm, buttery madeleines. And if you're craving international flavors, she recommends Habesha for Ethiopian feasts or Zia for New Mexican brunch near the Eiffel Tower. But this episode isn't just about restaurants. Amber and Annie dive into practical advice, like how to spot vegetarian-friendly dishes on French menus (hint: the sprout emoji doesn't always mean meat-free!) and where to shop for gourmet ingredients, like 30-month-aged Comté at Fromagerie Hardouin. You'll also learn what gifts to bring home—think French salt, artisanal butter, or vacuum-packed galettes—that food lovers will adore. What makes this conversation special? Amber's passion for Paris shines through as she proves that vegetarian dining in the city isn't about sacrifice—it's about discovering delicious, creative meals that celebrate French cuisine without the meat. Annie's warm, engaging style makes it feel like you're getting advice from a trusted friend, and by the end, you'll be ready to book your trip and eat your way through Paris like a pro. If you've ever wondered how to enjoy French food as a vegetarian, this episode is for you. Hit subscribe to Join Us in France so you never miss an episode, and get ready to explore Paris one delicious bite at a time. Perfect for food lovers, travelers, and anyone dreaming of their next French adventure! Table of Contents for this Episode [00:00:15] Introduction and Guest Welcome [00:00:31] Today on the podcast [00:00:58] Podcast supporters [00:01:24] Magazine segment [00:02:17] Vegetarian in Paris with Amber Haggerty [00:02:33] Living as a Vegetarian in Paris [00:03:21] Challenges of Being Vegetarian in Paris [00:04:31] Navigating Menus and Ingredients [00:07:58] Traditional French Dishes for Vegetarians [00:10:22] Favorite places to buy food in Paris [00:14:04] Favorite gifts to bring home [00:15:28] Favorite Restaurants and Creperies [00:19:35] Wine Bars and Cheese Tasting [00:23:27] Sweet Treats and Madeleines [00:24:43] Discovering Le Comptoir de la Madeleine [00:27:11] Exploring Jean-Paul Hevin Chocolatier [00:28:39] L'Avent Comptoir de la Mer: A Seafood Delight [00:30:17] Ethiopian Cuisine at Habesha [00:32:03] New Mexican Flavors at Zia [00:33:09] Vegan Delights at Plan D [00:34:29] Italian Salads at Cosi [00:35:54] Smash Burgers at DUMBO [00:37:03] American Breakfast at Holly Belly [00:38:08] Navigating Parisian Food as a Vegetarian [00:41:11] Last advice [00:41:52] International Food Scene in Paris [00:44:10] Final Thoughts and Farewell [00:44:59] Thank You Patrons [00:46:08] Tips for First-Time Travelers to Europe [00:46:46] Hotel Tips for European Travel [00:47:22] No toiletries in budget hotel [00:47:43] Bring Your Own Washcloth [00:48:01] Hotel Rooms are small [00:48:45] Turn on the lights [00:49:12] For Ventilation open a window [00:49:34] No Carpet in most Hotel Rooms [00:49:53] Essential Travel Items and Security [00:50:22] Understanding Power Converters and Adapters [00:51:17] Travel Light [00:51:33] Cultural Etiquette in Europe [00:52:13] Handling Problems Calmly in Europe [00:53:22] Renting and Driving Electric Vehicles in France [00:54:49] Charging Your EV in France [01:00:50] About the Price of Charging [01:01:46] Final Thoughts on EV Travel in France [01:02:38] Conclusion and Upcoming Episodes [01:02:51] Next week on the podcast [01:03:15] Copyright More episodes about French food and wine #VegetarianInParis, #PlantBasedParis, #ParisFoodGuide, #VegetarianTravel, #EatLikeALocal, #ParisDining, #MeatFreeFrance, #FoodieFrance, #ParisHiddenGems, #JoinUsInFrance, #FrancePodcast, #TravelFrance, #FrenchCulture, #ExploreFrance, #DiscoverFrance, #FranceTravelTips, #RealFrance, #Francophile, #FranceAdventures, #ParisFoodie