Podcasts about igf1

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Limitations of Conventional Parkinson's Treatment; Dietary Neurotoxins and Dopamine Cell Damage; Protein Excess and Dopamine Interference; Dopamine Pathways and Cell Protection; Medication Masks Symptoms but Doesn't Slow Disease; Early Cell Loss in Parkinson's and Prevention; Animal Fat Increases Parkinson's Risk; Organochlorine Pesticides and Brain Cell Death; Dairy Products Contain Neurotoxic Residues; Dairy and Parkinson's: Dose-Response Risk; Dairy Reduces Protective Uric Acid and Adds Toxins; Cheese and Pizza Amplify Disease Risk; Scientific Consensus Against Dairy in Parkinson's; Common Dairy Toxins Trigger Brain Inflammation #Parkinsons #BrainHealth #NeuroNutrition #HealthTalks

Please share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nyle00:00:00 - Intro00:02:40 - Podcast Start00:03:00 - Turkey Hair Transplant00:04:50 - Quitting Finasteride00:09:18 - Skull Needles & Anesthesia00:11:46 - Piercings Gone Wrong00:14:26 - Nipple Piercings00:17:15 - Meeting Melissa00:21:00 - 12 Weeks Out?00:24:11 - 90s Hardcore vs. Science00:32:10 - Digestion First00:37:00 - Off-Season Insulin Strategy00:40:48 - Gaining 15lbs in 3 Weeks00:42:37 - No More Chicken00:46:12 - Eating Raw Testicles00:49:04 - Fruit & Digestion00:50:48 - High Volume Training00:56:23 - How My Calves Died01:02:00 - Best Body Part01:05:49 - Vacuum & Gut Control01:08:00 - Career PED Dosages01:13:00 - GH & Insulin Timing01:16:48 - Insulin & Digestion01:19:00 - Current Cycle (300 Test)01:20:56 - Feeling Small (Deflated)01:24:46 - The IVF Journey01:27:10 - Gender Selection Laws01:28:22 - Daily Micro-Injections01:29:58 - The PMMA Scandal01:33:07 - No AIs Needed01:35:18 - Deca vs. Masteron01:37:05 - Why Masteron Now?01:38:52 - Aromatization Genetics01:41:47 - Future Cycle Plans01:47:55 - The 99ng/dL Crash01:53:23 - Peptides for Repair01:55:35 - Retatrutide for Bulking?02:01:11 - GHK-Cu for Skin02:02:40 - The White Fish Diet02:07:54 - Hybrid Training is a Trap02:09:30 - The Mindset of Peeled02:14:00 - Finding Your Volume Limit02:18:20 - The McDonald's Rebound02:22:11 - Marriage & Prep02:27:13 - The Greg Doucette Beef02:29:11 - Fertility on Gear02:32:30 - Patrick Tuor Era02:37:34 - Coaching CBum02:41:28 - 2024 Olympia Placings02:42:16 - The Smoking Video02:44:20 - Advice for Young Blasters02:46:06 - The "Trauma Pro"02:48:44 - Final Message

Please share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nyleTimestamps:00:00:00 - Intro00:03:19 Father Steve00:05:28 Banned on Social Media00:07:45 Raving00:12:06 Harm Reduction for Partying00:13:36 Alcohol Toxicity & "Cocaethylene"00:15:25 The Ultimate Hangover Stack00:18:54 Injectable Glutathione & NAC00:23:00 Rave Fashion: Cyclops Shades00:24:34 The Lifestyle Cutting Stack (TRT + GLP-1)00:26:58 The Crackdown on Peptides00:27:53 Cagrilintide Nightmares00:29:29 Orlistat & "Oily" Disasters00:31:36 Peptides for Naturals?00:33:57 The Sting of GHK-Cu00:35:23 Injectable Winstrol00:36:16 YK-11 vs. Superdrol00:39:21 Follistatin: Hype or Real?00:43:04 Mitochondrial Health Stack00:46:24 When to Start TRT?00:47:30 Adding Primo or Masteron00:50:36 My Tequila Mistake00:51:14 My Full Health Protocol00:53:11 What NOT to Take at Parties00:59:11 GHB vs. Alcohol01:00:00 High-Dose Melatonin01:02:17 Competitive Prep Stacks01:06:21 Nyle's Contest Cycle Revealed01:07:24 The "Pharmacy" Load01:13:38 Protecting the Brain (Neuroprotection)01:16:54 Epitalon & Longevity01:20:12 SGLT2 Inhibitors ("Biker Flows")01:21:15 Methylene Blue & Serotonin Syndrome01:24:42 Nootropics: Alpha GPC & Choline01:27:00 Noopept & Bromantane01:30:03 Tanner's Aston Martin01:34:55 Chinese Generics & Heavy Metals01:38:14 1000ng/dL Naturally?01:44:06 Underrated Meds (Telmisartan)01:46:24 Managing Cholesterol01:50:41 Equipoise Anxiety & Kidneys01:56:53 Hair Loss Prevention02:04:33 The "Femboy" Aesthetic Trend02:07:33 Future Drugs (Retatrutide)02:20:58 GLP-1s Saving Marriages02:23:18 Training Volume in Prep02:24:53 Low Iron in Bodybuilders02:27:12 Top 3 Steroids Ranked02:28:55 Substitutes for Primo/Mast02:30:52 Best Beginner Cycle02:34:44 Conceiving on Cycle02:38:16 Post-Cycle Muscle Retention02:41:40 Steve's Ladyboy Story02:50:49 NPP & Neurotoxicity02:52:10 Closing Wisdom

Renaissance Periodization: Training on gear vs. natty, how training styles affect the look of one's physique, slow vs fast twitch training, intensifiers & myoreps, peptides, the future of PED's, & myostatin inhibitors. The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 The Red Skin Phenotype00:01:25 Trensparent Origins00:03:23 Visual Diagnostics00:07:23 The Roundness Myth00:10:47 Vibes vs. Physiology00:15:46 The Failure Paradox00:18:15 Volume Kings00:22:23 The Thailand Spirit00:25:16 Genetic Determinism00:30:30 The Volume Response00:36:03 The DUP Protocol00:38:44 Glass Cannons00:43:42 The Recovery Trap00:51:37 Tech-Enhanced Gains00:54:00 Intensifier Logic01:04:02 Weed & Gains01:09:00 The Booty Clap Test01:10:12 The God Stack01:16:18 Exercise Mimetics01:18:04 The Post-Steroid Era01:24:12 The Final Message

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro05:00 The Patrick Tuor Strategy06:36 The 10-Gram Cycle Myth10:42 Winning a Pro Card on Orals13:53 Engineering Degrees & Bodybuilding21:05 The Best Version of Justin (2016)26:23 Emergency Room Horror Stories28:19 Olympia Afterparties Exposed33:58 Samson Dauda & Travel Meals37:26 Genetics: Muscle Bellies & Skin Thickness38:53 The Pop-Tart Peak Week Disaster45:07 Dangers of Cookie Cutter Cycles47:25 The 1000mg Testosterone Standard50:21 Hyper-Responders vs. Hard Gainers55:40 The 20lb Rebound Phase59:34 Building a Freak Natural Base01:02:13 Failing Classes for Prep01:08:24 Bodybuilders in Bar Fights01:14:30 Old School "Factory" Protocols01:28:22 Insomnia & Dementia Risks01:32:19 Generic vs. Pharma GH01:36:47 18IU Insulin Pre-Workout01:41:56 IGF-1 for Massive Legs01:45:32 The Infection That Ruined Prep (C. Diff)01:51:34 Increlex: The Nuclear Option01:56:40 Underground vs. Pharmacy Gear Strength01:59:25 Halotestin Rage & High Blood Pressure02:07:53 Hair Loss: Thyroid vs. Gear02:14:21 Eating Bear Meat in Alaska02:20:35 The 3 Heart Tests You Need02:32:37 Peaking for the Texas Pro02:40:12 Q&A: High Dose Winstrol Loading?02:49:15 Training 30 Weeks With No Rest02:51:54 Perfect Insulin Timing02:55:37 Fixing the IFBB Pro League03:06:20 Conclusion & Life Advice

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:01:26 Holidays & Work00:02:14 Vegas vs. California: The "Realness" Factor00:03:00 The Secret to 23-Inch Arms00:04:57 Genetics: Korean Calves & Ethnic Muscle Insertions00:06:30 The New Generation of Bodybuilders00:08:27 The Boston Lloyd Controversy: Truth vs. Harm00:13:11 Debunking the "10 Grams of Gear" Myth00:14:53 Natural Bodybuilding & Social Media Expectations00:16:47 The Limitless Mindset00:18:52 Evan's Origin Story: From Obese to Anorexic00:20:39 The "Perma-Cut" Trap: Fear of Eating00:22:46 Drugs Are Tools, Not the Foundation00:25:42 Losing Gains to Stay Lean (The Teenage Mistake)00:28:03 Winning the First Show & Turning Pro00:28:27 Starting PEDs at Age 19 (500mg Test)00:30:51 First Cycle Results & The "Cold Turkey" PCT00:32:45 Coming Off Gear: Bloodwork Reality Check00:34:28 Rebound Strategies: Staying On vs. PCT00:36:58 Testing TRT Levels & Fertility00:39:53 Host Message: Subscribe & Sponsors00:41:03 First Growth Hormone Experience (Serostim)00:41:50 The Holy Trinity: Test, Tren, & Winstrol00:44:12 Injectable Winstrol: Alpha Pharma Rexogin00:46:26 Oral Winstrol Side Effects: Gut Health & Acne00:49:02 Quitting Orals (Reflux Issues)00:51:55 Modern Coaching Lunacy: High Dose Orals00:53:26 Acute Toxicity: Why Injectables are Safer00:58:09 Finding "Real" Injectable Winstrol 101:00:55 GH Strategies: Prep vs. Off-Season01:02:13 Insulin Without GH? The Joe Palacios Anomaly01:03:11 Is Growth Hormone Overrated?01:04:26 Cycling GH: 2 Days On, 1 Day Off01:05:21 The Ronnie Coleman Standard01:06:09 The GH15 Era & Internet Rumors01:09:42 The "One Bottle of Sustanon" Pre-Stage Protocol01:13:28 GH Frequency Debate01:16:19 What Pros Actually Take: The 4-6 IU Reality01:19:02 Steroids in Japan01:20:41 Earning the Pro Card01:21:10 2009 NY Pro Win & The Oscar Ardon Era01:23:58 Passion vs. Career: The Bodybuilder's Dilemma01:28:44 Evan's Heaviest Cycle: 1,500mg Test & Suspension01:30:55 The Cytadren (Aminoglutethimide) Nightmare 201:32:43 Diuretics & Dangerous Prep Protocols01:34:26 Insulin Frequency & Diabetes Risk01:37:53 Dangerous Modern Coaching: 100mg Orals Daily01:40:15 Longevity & The "One Vice" Rule01:43:45 Essentiale Forte: The Ultimate Liver Supplement 301:45:33 Host Message: Transcend HRT01:46:20 Training Philosophy: Oscar Ardon's "Mental Torture" 401:50:38 Science-Based Op

Placing 2nd at Texas Pro. Real talk the whole time, everything you'd want to know, from the deep sht to how they blew up and the juicy deets in between. Honored to know these bros. The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00Intro 00:02:21The Post-Show Dopamine Crash vs. Prep "Grumpiness"00:02:42Relationship Survival Guide: "The Pre-Emptive Apology"00:04:31Reading Cortisol: Why "Low" Can Be Worse Than "High"00:05:12Adrenal Burnout Protocol: "Baby Sessions" & No Cardio00:06:52Elliot's Pro Debut: Navigating the "Growing Pains"00:07:29The "Food Noise" Reality: When One Donut Turns into Four00:08:03Retatrutide ("Retta"): The 2mg Protocol for Appetite Control00:09:19Flashback: The Misery of the 1100-Calorie Natty Prep00:12:14The Cult Following of the Unranked Podcast00:14:41The Origin Story of the "Unranked" Name00:16:19The Great Debate: Health Phase vs. Aggressive Rebound00:18:43The Burnout Checklist: When to Abort the Rebound00:20:10Metabolic Adaptation: When the Body Stops Responding00:23:29Methylation Hacks: Methyl Folate & The MTHFR Mutation00:25:31The "Mic Check" Comedy Segment00:28:05Andrew's Origin: The Magazine Era (1996)00:33:58Kyle's Origin: The Mentorship Era (2014)00:37:54Joining the "Dark Side" at Age 10? (Andrew's Story)00:39:57Andrew's First Cycle: The "Tren & D-Bol" Kitchen Sink00:42:00Kyle's First Cycle: Pro-Hormones & Peer Pressure00:43:19The "Mad Scientist": Snorting Andro at Age 1400:45:10The Golden Rule: Wait Until 25 (Or 30)00:47:09The "Natty Ceiling": Switching to the Dark Side (Chris's Story)00:49:58The Halo-Only Nightmare: A Lesson in Hormonal Crashing00:56:27Financial Advice for Young Pros: Freeze Your Sperm01:03:16Training Mistakes: The "Two-a-Day" Trap01:06:57The Meadows Hack: Binge Until You're Sick01:10:54The "Dreamer Bulk" Mistake: Fat Doesn't Turn to Muscle01:13:00The Secret to Rebounding: Stay "Hungry" & Insulin Sensitive01:21:38Executing the Health Phase: Diet & Training Adjustments01:26:47The "Zero Carb" Depletion Experiment (Martin's Protocol)01:35:19Peak Week Orals: Managing Winstrol & Digestion Issues01:40:52The "Detox Week" Protocol: No Training, Med Diet01:44:11Setting the Cap: Max Weight Gain Post-Show (10-15%)01:49:49The "Soft Landing": Using Primo/Proviron to Bridge01:51:25The "No-Go" List: DNP & Dangerous Diuretics01:

Placing 2nd at Texas Pro. Real talk the whole time, everything you'd want to know, from the deep sht to how they blew up and the juicy deets in between. Honored to know these bros. The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00Intro00:03:43First Cycle Experience00:06:1290s Mentality vs. Modern Science00:08:00Mental Side Effects & Anxiety00:09:22"Death Face" at the 9-to-500:15:51Fat Kid to Anorexia: The Origin Story00:23:51The 80lb Binge Eating Rebound00:26:34Losing Dad & Finding Purpose00:34:52The Reality of Being 300lbs00:40:17Blood Work & Kidney Health00:45:22Coming Off vs. Cruising00:58:198,000 Calories & The McDonald's Diet01:08:49Growth Hormone & Insulin Protocols01:13:01Injection Sites: The "Ass Fat" Method01:15:51Sleep Apnea & The Death Rattle01:21:15The Secret to Transformation01:36:02The Disney World Scooter Incident01:37:49Gaining 50lbs in One Cycle01:45:07Dosage Evolution (Year 1 to Pro)01:51:23Crying While Force Feeding01:58:17Current Cycle Reveal02:09:26Training: Volume vs. Intensity02:15:20The "Death Cocktail" Prep Cycle02:23:12Essential Health Supplements02:45:07Final Message to the World

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 – Intro00:02:28 – Remote vs. In-Person Peaking00:03:50 – Data Driven Coaching00:06:13 – First Cycle Philosophy00:09:31 – Post-Show Buffer Protocol00:11:02 – The Estrogen Myth00:14:14 – The Calcium Score Imperative00:15:59 – The Vitamin D3 Danger00:17:49 – Death by Potassium00:20:23 – Halo vs. Superdrol00:27:37 – Thyroid Tapering00:30:59 – Western Medicine vs. Bodybuilding00:33:16 – The Rebound Phase00:37:42 – Female Androgen Health Effects00:44:31 – Metformin vs. Berberine00:48:18 – Myostatin & The Future of PEDs00:52:23 – Training is what matters most00:58:00 – Fixing Back Training01:05:26 – From Dietitian to Super Coach01:14:32 – Insulin Sensitivity & Gut Health01:23:03 – Peak Week Glucose & GI Health Management01:31:01 – The Dyazide Strategy01:41:02 – The GLP-1 Trap01:54:31 – Classic Physique Weight Cuts01:56:14 – Stanimal Case Study02:09:48 – Insulin & HGH Synergy02:15:42 – Why Modern Bodybuilding is Soft02:21:35 – Designing the Offseason Cycle02:37:05 – Waist Control Secrets02:40:33 – Nick Walker & Coaching02:43:27 – Female PED Safety02:52:36 – Fertility & Sperm Banking02:55:40 – The Final Message

How he improved drastically from his last year with Jansen - Did he deserve to beat Urs?  ⁨@Quintbeastwood⁩  YoungLA BLACK FRIDAY SALE: https://www.youngla.com/discount/nyleCode ‘NYLE' for 30% off to support the podcastThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 – Intro00:08:41 – Why This Was His Best & Most Consistent Season Ever00:14:05 – How Much Easier This Prep Was vs. Matt Years00:19:40 – The New York Pro That Broke Him00:26:47 – Off-Season Weight, Calories & Smarter Approaches00:36:55 – Peak Week Breakdown: Depletion + Carb Loads00:44:00 – Glutamine Mega-Dosing & Gut Health for Peak Week00:47:21 – Germany Show Was His Favorite Trip Ever00:49:34 – What Quinton Packs for Overseas Shows00:55:26 – Running Almost No Orals vs. Winstrol Experiment01:00:17 – Managing a Tiny Waist on Stage01:04:34 – Water Manipulation Mistakes & Lessons01:10:09 – Why Self-Coaching Gave Him His Best Season Ever01:13:50 – Salt, Spillover & Why Judges Prefer Fuller Looks01:19:00 – The Look Judges Want From Quinton01:23:17 – When You Can't See Yourself Objectively01:25:17 – Judges Reward Muscle Pressure Over Shape01:34:19 – Staying Smiling & Confident on Stage01:46:31 – Bodybuilding Pulled Him Through Ruts01:53:06 – PPL vs. Bro Split Thoughts01:56:56 – New Health Phase: Cardio & Controlled Food02:01:23 – Balancing Opinions With Self-Analysis02:04:26 – Prioritize Training Above All02:09:10 – Peptide Recovery: MOTS-C & BPC-15702:20:15 - Leg Cramps02:29:44 – Brittany Brought Life Balance02:32:32 – Say “F*** It” & Take Risks02:33:41 – Kidney Health on Point02:35:55 – Message to the World: More in Common02:38:48 – Closing Thanks & Giant Potential

Dr. Dean St. Mart returns.YoungLA BLACK FRIDAY SALE: https://www.youngla.com/discount/nyleCode ‘NYLE' for 30% off to support the podcastThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 Intro00:06:11 NHS Hospital Nightmare & Surgery Delays00:17:45 Enhancement Perspective – Shoes, Tech & Humanity00:22:32 Fast vs Slow Metabolizers Explained00:30:19 Best Injection Sites: Glutes vs Delts00:38:01 10 Grams of Test 00:45:00 Posing Injuries & Calf Cramp Story00:55:19 Dean's Full 2024 Contest Prep Cycle01:05:31 Reps in Reserve Revolution – Growing With Less Drugs01:21:03 Low-Dose Stack – Slow & Steady Wins01:32:45 Stomach Acid & Bile: First Line of Defense01:42:09 Androgenic Overload – Hair Loss & Acne Signals01:52:51 Modern Abuse: 3–4g Doses Without Results02:06:26 Why Coming Off Gear Can Boost Gains02:15:14 GH Dosing Deep Dive02:24:41 SubQ vs IM GH Absorption Debate02:32:49 Systemic vs Local Effects (GH & IGF-1)02:39:11 Protecting Your Future Health02:40:12 Podcast Wrap & Goodbye

4th at Olympia 2025, 5th at Olympia 2025, & Prague Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:10:13 Sleep Stack: Melatonin, GABA, L-Theanine00:16:34 Pittsburgh Pro Miss & Mental Reset00:20:36 Olympia Flatness vs. Prague Peak00:25:12 Prague Peak Recipe Perfection00:31:10 Olympia Migraine Backstage00:35:23 Earlier Hammer Drop (6 Weeks Out)00:40:20 Strict Salt/Water Tracking (10g/5L)00:44:49 Pulling Test Early in Open vs. Classic00:53:18 Yo-Yo Feeding Strategy01:00:36 TB-500 & BPC-157 for Injuries01:04:47 Winstrol Sides & Inflammation01:10:16 Blue Collar to Pharmacy Journey01:18:23 Beating 5 Mr. Olympia Champs01:24:49 Data-Driven Confidence01:34:29 Anti-Shrink Secrets01:36:48 Slow Gains, Max Detail01:44:41 Videographer Coop Magic01:47:18 Cream of Rice Hack01:51:17 Water Retention Balance01:55:24 Fat-Holding Edge02:01:03 Lean Protein Choices02:03:21 Muscle Fatigue Battles02:08:00 X-Frame Strategy02:11:14 Dehydration Balance02:12:47 Parabolan PED Vibes02:15:21 Bloodwork Monitoring02:20:03 Insulin Off-Season Use02:23:01 Insulin & Cardio Effects02:27:00 Insulin & Blood Pressure02:30:00 Insulin & Test Levels02:33:30 Glutamine GI Benefits02:36:45 Tips for Sport Success02:40:56 Grateful for Bodybuilding02:44:33 Journey Support Thanks

Olympia 2025 for 212 bodybuilding shocked people. John Jewett took over Shaun's prep for Olympia and brought an unexpected package vs. Keone Pearson.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 – Intro02:31 - Catching up08:44 – Why Competing Overseas Is a Nightmare12:36 – Judge Feedback: Fuller + Chest/Quads20:51 – Shaun Clarida's Best Olympia Peak Ever24:00 – Rebounding After 2024 Olympia30:33 – Peak Week Strategy: Simple Always Wins32:27 – Managing Backstage Chaos at Olympia36:20 – Zero Diuretics for Shaun Clarida41:15 – Peaking Pro Tip: Start Simple44:41 – Data Logging = Perfect Peaks45:30 – Shaun's 182lb Magic Window48:53 – Fake GH? What Happens When It's Pulled50:01 – Clen Mistakes & Monster Carb Loads56:00 – Simple Peaks Beat Complicated Protocols58:30 – Martin Fitzwater's MONSTER Fill-Out01:00:47 – Sodium Strategy: 3–5g Daily01:06:57 – Backstage Snacks: Glucose vs Fructose01:12:10 – The 3-Exercise Pump Routine01:18:33 – Winstrol Experiment: Fuller but Softer01:25:28 – If You Could Only Run One Steroid…01:26:51 – SuperDrol: Bull Mode01:32:23 – Shaun's Training: Less Volume, More Gains01:38:40 – Fasted vs Fed Cardio01:43:04 – Steady-State Wins for Conditioning01:50:42 – Cutting the GI Protocol Down01:58:22 – Retatrutide Update & Lipid Focus02:00:14 – Masteron Muscle Myth Busted02:04:16 – Biggest Regret: Should've Hired a Coach02:06:09 – Pro Life: Keep Showing Up02:16:24 – Final Message

2025 Olympia, Family, PED's, & From The Start Til NowThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 – Intro00:01:42 – Marriage & Relationship Challenges During Prep00:04:27 – Filipino Inspiration & Bodybuilding Legacy00:07:15 – Coaching Joven to the Olympia00:11:09 – Rebuilding After the 2018 Crash00:14:25 – Top 10 Validation & Shutting Down Haters00:16:56 – Stoik Gym: Local Grind to Global Expansion00:21:18 – 18-Hour Prep Days: Building the Blueprint00:25:24 – Fatherhood Struggles During Prep00:31:25 – PED Awareness & Brain Chemistry00:35:07 – Downfall Lessons & Accountability00:43:18 – OCD Since Age 6: Pain to Empathy00:48:59 – Career Rollercoaster & Public Perception00:56:09 – Stoik Vision: Pros Building Pros00:59:46 – Attitude Kills Deals: Losing Everything01:03:18 – The Total Package: Physique + Communication01:06:41 – Backstage Battles & God's Plan01:12:54 – TRT, Peptides & Health Optimization01:17:02 – Proud Dad Shift: Value Beyond Stage01:26:45 – Recovery Mindset: Faith & Muscle Memory01:31:15 – Diet Is King: 5–6 Meals Over Gear01:35:57 – Final Message: Treat People Right, Kill Loneliness

Olympian & 3x Classic Pro ChampThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 - Intro01:26 - Starting Chat and Merch Talk10:35 - Early Training & First Competition20:32 - Post-Show Binge & Taco Bell Story27:07 - Dessert Obsession & Mukbang Talks33:17 - Low Libido in Prep & Recent Wins36:12 - Dealing with Losses & Growth Mindset40:24 - Embracing Suffering & Process48:23 - Lessons from Last Season & Positivity54:17 - Pressure, Stability & Financial Struggles56:01 - Vegas Trip & First Flights1:03:07 - Travel Strategies & Pro Lifestyle1:12:18 - Hardships, Inspiration & Adversity1:16:12 - Competing Against Daniel & Stage Reality1:18:59 - Tanning & Glaze Lessons1:25:16 - Backstage Anxiety & Timing Errors1:31:08 - Pump Timing & Anxiety in Prep1:46:55 - Classic Division Surprise & Point System1:52:54 - Passion for Competing & Vegas Vibes01:55:07 - Post-Show Health & Growth Strategy2:02:09 - Progress Pics & Cycle Breakdown2:07:20 - Low Dose Philosophy & Longevity2:10:28 - Lab Work & Supplement Insights2:31:09 - Posing Flow State & Stage Confidence2:34:52 - Prep Reduces Anxiety & Staying Ready02:39:38 - Gut Health & Peak Week Tactics2:44:31 - Back Weakness & Training Fixes2:48:15 - Olympia Predictions & Expo Stage Chat3:00:39 - Final Show Reflections & Lessons3:03:29 - Olympia Hype & Vegas Linkup Plans03:04:26 - Control What Matters & Gratitude3:05:24 - Clothing Deals & Meeting Appreciation3:06:29 - Transparency & Meaningful Impact3:07:09 - Vegas, Brownies & Farewell

Olympian in 212 and now Classic.  @thedurrah  The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro03:19 - Carb Up & Diuretics08:45 - Lineup Drama & Feedback15:19 - Full vs Dry Debate20:58 - Bloodwork Wins & Health Markers25:43 - Water Retention & Dosing40:32 - Schedule Stress & Experience Edge50:06 - 212 vs Classic Prep57:48 - Surgery Loss to Suicide Shift01:03:48 - Quick Q&A & Peak Strategies01:06:26 - Future Moves & Olympia Cycle01:11:39 - Rebound Tips & Self-Coaching01:13:37 - Fatherhood Paradox & Olympia Path1:17:46 - Peace Out

Evidence-Based Olympian IFBB Coach of pros like Jordan Hutchinson & Host of IFBB AMAThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro00:04:00 - Value of Transparency & Gear Evolution00:09:24 - Genetics and Drug Strategies00:14:10 - Post-Surgery Growth & Gear Myths00:19:30 - Smart Training & Rebound Management00:26:50 - TRT, Recovery & Tissue Retention00:32:40 - Parasympathetic Recovery & Sleep Struggles00:37:20 - Individualized Training & Overtraining Risks00:43:50 - Smart vs Hard Training Myths00:48:24 - Chest & Leg Training Insights00:52:30 - Jordan's Olympia Prep & Peaking Strategy01:00:00 - Stress-Free Prep & Weight Management01:05:15 - Sleep Hacks & HRT Checkups01:09:04 - James' Prep & Fullness vs Condition01:15:20 - Fruit, Food & Force-Feeding Myths01:22:00 - Gear Balance & Client Collaboration01:26:20 - Retatrutide & New Drug Cautions01:29:29 - Fat Loss Stories & Microdosing01:33:15 - Prep Catastrophes & Client Communication01:38:08 - Offseason & Reverse Diet Strategies01:51:28 - Post-Show & GH Timing Tips02:01:10 - Sugar Timing & Glycemic Control02:06:54 - Stage Experiences & Confidence02:12:11 - Carb Cycling02:24:41 - How Chris Started with James 02:34:10 - Chest Support Pads Restricting Stretch02:38:46 - Final Question

2x Mr. Olympia Runner-Up, 2x Arnold Classic Champ, USAF Veteren, one of the greatest posers of this era & potentially of all time, and one of the top contenders for the Classic Mr. Olympia title in 1 weekThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 Intro2:19 Breathing Fixes in Prep4:29 Coaching Shift & Gym Updates00:07:13 Pricing Real Talk00:08:19 Success Mindset 16:01 Olympia Plans & Prize Money Talk 18:38 Mr Olympia Beyond Bodybuilding00:21:46 Weider Influence & Sport Growth 27:05 Stage Setup & Judge Analysis 31:46 Jose's Improvements 36:59 Years Left in the Sport 41:42 NY Pro Peak 45:52 Carb Boost Strategy 49:43 Dehydration Fatigue 55:15 Rhomboid Focus 1:02:04 RPG Love 01:07:29 Friend Support 01:15:53 Olympia Packing Insight 1:25:33 Training Priority 1:34:05 Life Purpose Beyond BB 01:38:15 Legacy Building 01:45:03 Hair Transplant & Aesthetic Shift 01:54:21 Transformation 02:05:00 Final Message

PhDc endo & expert on bodybuilding pharmacology & enhanced bodybuilding scienceWatch it: https://www.youtube.com/watch?v=LXErTWYFxBM&lc=Ugyh4j4EKOMWMx7bCDd4AaABAg.ANg5e8KTLa5ANgOVCTnFlCThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 Intro00:04:06 Book Updates & GH Research00:08:55 GH, DHT & Acromegaly00:13:29 GLP-1 & Offseason Nutrition00:18:10 Classic vs Open Bodybuilding00:24:31 Leg Growth & Fiber Types00:28:41 Time Off Gear & Recovery00:34:49 Training Frequency & Volume00:41:18 Prep Cycles & Orals00:46:48 Diet & Fullness Strategies00:49:36 Moving & Compound Reactions00:51:32 GI Health & Peptides00:55:49 Cardio & Skin Thickness01:03:05 Sleep Solutions & Aids01:10:32 Choline & Cognitive Health01:12:20 Surgery Recovery & Female HGH01:18:17 Blood Pressure & Hematocrit01:25:10 Cardio, Fat Loss & Yohimbine01:33:08 Favorite Bodybuilders & GH Dosing01:39:43 GH Injecting best practices01:43:53 Final Message to the world

The first growth factors identified and studied during the early 1970s were Epidermal Growth Factor (EGF) and Nerve Growth Factor (NGF). It was soon demonstrated that EGF and NGF mediate their cellular and physiological effects by binding to specific cell membrane receptors: the EGF receptor (EGFR) and the NGF receptor (NGFR), respectively. The mechanisms of activation and signaling of these receptors were compared to those of insulin and IGF1, which bind and activate the Insulin Receptor (IR) and IGF1 Receptor (IGF1R). These comparisons gained further significance with the discovery that EGFR, NGFR, IR, IGF1R, and many other membrane receptors belong to the receptor tyrosine kinase (RTK) family of cell signaling molecules. Early insights into the activation and signaling mechanisms of EGFR revealed that ligand binding to its extracellular domain induces and stabilizes the formation of EGFR dimers. This dimerization plays a critical role in activating the receptor's intrinsic tyrosine kinase activity. Through an intermolecular process, this activation leads to the autophosphorylation of multiple tyrosine residues in the C-terminal tail of EGFR. The cytoplasmic domain of EGFR serves not only as an enzyme that phosphorylates various substrates but also as a scaffold that recruits and regulates multiple signaling proteins through complex formation. While different ligands induce RTK dimerization and activation through variations on a shared theme, this paradigm is universal among all RTKs and is similarly observed in the activation of other surface receptors. Further important discoveries regarding the mode of action of EGFR and other RTKs made during the 1970s and 1980s include the following: Signaling Modules: Molecules containing SH2, SH3, and other small protein modules were found to play key roles in mediating cellular activities downstream of RTKs and many other signaling molecules. Ligand-Dependent Endocytosis: Ligand binding to the extracellular domain of RTKs stimulates receptor-mediated endocytosis and intracellular trafficking ,which are essential for proper signal transduction. Oncogenic Mutations: A variety of gain-of-function oncogenic mutations were identified in EGFR and other RTKs. These mutations were shown to be critical drivers of many human cancers. These early discoveries, along with others made during the 1980s, laid the conceptual groundwork for the development of targeted therapies. They paved the way for the discovery and clinical application of more than 50 targeted small-molecule cancer drugs and therapeutic antibodies, which have significantly improved patient outcomes in oncology.

Open Bodybuilding Olympian, 3x IFBB Pro Champion, pro podcaster in the IFBBAMA and can be often seen on Bodybuilding & Bollocks on the Real Bodybuilding Podcast.Watch it: https://youtu.be/gPfRK3HoAAYThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro to James Hollingshead04:40 Early Bodybuilding Journey and Influences09:18 Deep Dive into Nutrition and Longevity19:16 Steroid Use and Its Impact on Career26:14 Mindset and Overcoming Hardships38:00 Health Monitoring and Genetics46:20 Optimizing Training Splits57:46 Balancing Bodybuilding and Mental Health01:07:25 Dealing with Loss and Finding Purpose01:18:56 Favorite Prep Memories01:26:04 Best Peaking Show Memories01:33:27 Truth About Dosages01:45:36 Rep Ranges for Hypertrophy01:51:35 Offseason Strategy: Mass vs Conditioning01:55:24 Fertility While on Cycle01:57:14 Favorite Compounds02:00:02 Appreciating the Whole Physique02:04:23 Views on Lifting Styles02:07:51 Balancing Fatherhood and Bodybuilding02:14:45 Therapy and Travel Insights02:17:56 Final Message to the World

Markus Hunter IFBB Pro:  ⁨@Markusfit⁩  The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 - Intro5:43 - Social Media Perceptions and TikTok Labels10:00 - Content Creation Struggles and Polarization17:15 - Reasons for Mindset Change20:00 - Constructive Criticism and Impact Stories26:43 - Insane Tren Doses and Variations30:00 - Gear, Genetics, and Growth36:38 - Learning Your Body and Coaching45:56 - Sleep Aids and Health Risks50:00 - Crazy Cycle Stories58:19 - Back Training Revelations59:47 - Men's Physique vs. Open Bodybuilding1:10:00 - Chasing the Pro Card Reality1:20:00 - Pro Card Struggles and Triumphs1:28:20 - Importance of Sex in Relationships01:29:56 - Best Prep Look Without Diuretics1:40:22 - Cycle variations01:49:12 - Biohacking for Optimal Performance01:59:40 - Evolving Training Strategies2:10:00 - Next Pod Plans02:12:38 -Best way to use superdrol02:18:57 - Growth Hormone02:30:46 - Gear Guidance for Newbies02:36:05 - Gut Health2:50:00 - Long Prep Secrets02:57:12 - the final message02:59:26 - Being Self/ Family Centered as Men

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro00:02:08 Coaching Men vs Women & Hormone Challenges00:06:55 Discovering Bodybuilding & Early Training Mistakes00:11:26 First Competition & Prep Lessons00:15:39 Diuretics vs Natural Peaking00:21:17 Athlete Examples & Conditioning Standards00:25:37 Precision in Bodybuilding & Coaching Start00:31:50 Success with Physique Athlete & Olympia Journey00:36:00 Meeting & Working with Terrence Ruffin00:44:13 Fullness, Dryness & Peaking Challenges00:49:32 Coach–Athlete Learning Curve & Comparisons00:55:49 Classic Physique: Shape vs Conditioning01:02:42 Defining a Good Coach & Athlete Safety01:08:48 Health Supplements & Blood Work Frequency01:15:10 Downsizing for Classic Physique & Compound Choices01:22:12 Individual Reactions & Instagram Misinformation01:26:56 Food Intolerances & Insulin Sensitivity Tips01:33:55 Blood Pressure & Root Problem Fixes01:34:54 Off-Season Training Focus & Nutrition01:39:48 Intensifiers01:44:36 Coaching Anxiety & Life Perspective Shifts01:51:29 Olympia Wins & Chasing Coaching Legends01:55:25 Tips for Young Self & Helping Athletes02:05:05 Tren in Men's Physique & Side Effect Management02:17:53 Hyacine's Proudest Moment02:20:59 Superior Genetics?02:22:34 Clen Use & Side Effects02:33:52 Dubai Bodybuilding Scene & Gyms02:37:34 Dubai Lifestyle & Safety02:42:12 Advice for New Coaches & Mentorship02:46:50 Final Message & Podcast Wrap-Up

The most honest & vulnerable this pod has potentially gotten. Death, pain, drugs, cheating in relationships, divorce, mental health adversity, injury leading to inability, & disease, all experienced by one person, alone. That's what many of us men go through and I'm glad Steve opened up about it today.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]http://www.transcendcompany.com/nylenaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:0:00 Intro & Starting Convo5:19 First Meeting & Bodybuilding Beginnings10:44 Lessons from Adversity15:01 Coaching Nightmare & Recovery17:41 Naivety in Coaching → Self-Education22:49 Relationship Red Flags & Cheating Signs26:10 Porn Addiction & Marriage Impact29:41 Final Confrontation & Fresh Start32:28 Coaching Philosophy & Client Focus36:18 Toxic Relationship Cycles40:54 Gaming Escape & Life Balance42:44 Bouncing Back Strong44:21 Childhood Loss & Emotional Suppression48:24 Healing Through Community51:21 Positive Mindset Shifts54:32 Losing Loved Ones & Grief1:02:10 California Escape & Life Reorientation1:06:34 Pat's Lasting Impact1:11:37 Chosen Bonds & True Friendship1:15:19 Creating Impactful Content1:19:54 Keeping It Real on Social Media1:23:15 PED Experiments & First Prep Dosages1:27:00 Mental Strength & Stoicism1:30:05 PED Effects & Genetic Factors1:44:07 Dexa Scan & Injury Struggles1:48:19 Prep Lessons & Stress Relief1:55:10 Microdosing & Health Phases1:58:13 Travel Nightmares & Food Poisoning2:03:20 Blood Work & Health Optimization2:05:14 Rural Grind & Work Ethic2:08:37 Training Revolution & Physique Evolution2:19:59 Weight Struggles & Bulking Mindset2:23:04 Client Coach Relationships2:29:14 Moderate Dosing & Low Dose Gains2:34:14 Conscious Choices & Coaching Insights2:36:54 Prep Relationship Struggles2:41:06 Relationship Support & Competitive Balance2:43:44 Nutrition Hacks & Insulin Gains2:47:20 Gut Health & Recovery2:53:42 Stretching & Injury Prevention2:56:22 Pro Goals & Offseason Strategy2:58:54 Risk Management & Blood Work3:00:48 Final Message & Positive Impact

The most uncensored guest I've ever had. He always has knowledge to share that has me realize there's something new for me I haven't been looking into.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 – Intro00:03:19 – Caffeine Kickstart00:06:19 – Metabolism & Side Effects Breakdown00:10:55 – Stack Design & Mixing Compounds00:14:48 – Injection Methods & GH Dosing00:20:15 – Practicality in HRT & Nuanced Advice00:25:05 – Injection Scar Tissue & Absorption00:26:56 – Prep Strategy & Mini Cuts00:32:17 – Coaching Approaches & Hormone Levels00:35:14 – Estrogen, Gyno & Anabolics00:41:45 – Healthcare System Critique00:45:40 – Medical Ethics & Corruption00:50:56 – Progress Algorithms & Training Style00:55:45 – Aging, Growth & Rep Ranges01:00:42 – EQ vs Primo & Kidney Concerns01:03:27 – Anecdotal Evidence01:18:43 - Methylene Blue Cancer Risk01:21:11 – Retatrutide & Prep Secrets01:27:08 – Masteron vs Primo & Cycle Choices01:31:54 – Back Growth & Training Pitfalls01:35:35 – Genetic Risks & Bodybuilding Myths01:38:38 – High-Frequency Gains01:40:27 – Final Message & Wrap-Up

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com0:00 – Intro1:55- Prep vs Off-Season Diet4:56 – Stretching before the show6:55 - Dubai Pro Success9:40 – Switching to Machines12:07 – Dealing with Personal Issues15:45 – Coaching Myself17:52 – Stomach Issues & Solutions23:52 – Cutting Compounds Early27:25 – Working with Patrick29:38 – Trusting My Instincts34:00 – Improving Lats41:02 – Leg Training Insights44:39 – Reverse Grip for Lats45:35 – Using Drop Sets & Intensifiers53:34 – GLP-1 & Digestion Concerns1:08:30 – Secrets to Insane Conditioning1:13:20 – Making Weight for Shows1:21:00 – Moderate Peak Week Philosophy1:23:30 – Gradual Carb Increase Strategy1:38:43 – Michaels's Favourite Off-Season1:40:35 – High Doses, No Gains1:49:30 - Compounds that didn't work for Michael1:54:50 – Financing Bodybuilding as a Pro1:59:38 - Mindset is everything2:04:50  - Most important supplements2:07:00 – Final Message to the World

IFBB Pro Open Bodybuilder, 2023 Chicago Pro Champ, & Olympian, known for his wild proportions & training style.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro02:05 - Pod Setup03:41 - Relationships & Personal Stories05:04 - Dealing with Loss13:20 - Grief and Maintaining Routine16:27 - Navigating Life Transitions21:40 - Contest Prep Updates27:08 - Gut Health Protocol Impact30:59 - Lifelong Gut Issues42:36 - Justin being comparatively small44:35 - Cycles, Training Styles & Genetics50:16 - You are not gonna feel great all the time!54:44 - Eric Janicki & Training to Failure01:03:44 - Journey to Bodybuilding01:08:52 - Longevity in Bodybuilding01:14:25 - Growth Hormone Experiences01:18:34 - Training Style Evolution01:20:09 - Coach Behind Justine & Motivation01:27:03 - Balancing Bodybuilding, Business and Relationships01:32:02 - Being Raised Perfectly01:40:33 - Moderate Dosage Benefits & Being Health Conscious01:47:49 - Consistency in Training01:55:21 - Acne Struggles & Solutions02:04:58 - Obsession vs. Balance in Prep02:09:06 - Peak Week Nutrition02:14:04 - Frenchie vs. Pug Debate02:19:33 - Cannabis Business Role02:24:33 - Delegating in Business02:27:00 - Getting competition lean on burgers02:32:23 - Training Frequency Benefits02:39:55 - Exercise-Specific Training02:43:59 - Back Density Movements02:46:34 - Olympia Stress Disaster02:57:10 - Do What You Love

Strongest legal performance enhancers, methods, and more to improve your recovery, endurance, overthinking, mental clarity, cognition, fatigue threshold, longevity, and so much more to get the edge on your competition.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 – Intro to Dr. Scott Sherr00:02:27 – Podcast Warm Up - Dr. Scott's teachings and bodybuilding00:05:40 – Brain Health in Bodybuilding00:08:12 – Overtraining & Parasympathetic Recovery Challenges00:10:32 – Post-Workout Parasympathetic Strategies - GABA00:14:02 – CO2 Tolerance Training for Performance00:16:42 – Breathwork Techniques for CO2 Training00:20:03 – Caffeine & Nicotine in Workouts00:23:12 – Individual Responses to Supplements00:27:13 – Deep Dive into GABA & Supplementation Risks00:37:40 – GHB & Phenibut for Deep Sleep00:42:44 – GABA supplementation/ Glutamine & Gut Health00:46:15 – Caffeine & Nicotine for Brain Health00:52:56 – Nootropics: Health vs. Performance01:04:11 – Blood Sugar Control & Key Supplements01:12:49 – Methylene Blue for Performance01:20:29 – Hydration + Methylene Blue Travel Stack01:22:03 – Methylene Blue Dosing, Safety & Delivery01:28:41 – Methylene Blue Success Stories01:33:50 – Sleep Optimization: Sauna & Hyperbaric Therapy01:39:03 – Hyperbaric Therapy Explained01:50:56 – Mitochondrial Health & Sexual Performance01:53:24 – Where to Find Dr. Scott

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro01:45 - Greg Doucett/ Kyle's Backup Team06:29 - Connecting Through Social Media09:43 - Inspiring Others with Disabilities11:29 - Overcoming Stereotypes with Bodybuilding15:45 - Feeling Left Out27:21 - Kyle's Diagnosis Story32:23 - Journey with Down Syndrome39:12 - Hormone Therapy Discussion48:41 - Testosterone Therapy Progress55:30 - Venice Beach Victory1:00:06 - Training Mindset & Failure1:04:05 - Manifesting Success1:07:15 - Men's Mental Health1:14:11 - Dealing with Depression1:20:11 - Finding Purpose in Tough Times1:23:20 - Kyle's Superhero Mindset1:27:32 - Kyle's Journey So Far1:39:17 - No Challenge is a Challenge for Kyle1:47:00 - Feeling Isolated and Finding Community1:50:19 - Nick Walker's Inspiration1:53:15 - Dealing with Anxiety2:03:15 - Connecting Through Opening Up2:11:20 - Final Message to the World

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder: [ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro  00:02:40 Personal Life Updates  00:04:51 Pregnancy and Lifestyle Changes  00:10:57 Early Steroid Use and Coaching  00:18:43 Sleep Schedules and Productivity  00:26:45 Bodybuilding Industry Evolution  00:27:52 Modern Bodybuilding Aesthetics  00:37:31 GLP-1 Agonists and Nutrition  00:41:37 Classic Physique and Weight Caps  00:46:51 Coaching and Knowledge Evolution  00:53:07 Family Genetics and Hard Work  00:56:55 Diminishing Returns With Protein  01:08:23 Growth Hormone Dosing Insights  01:16:41 Insulin and GH Combinations  01:22:54 Elite Coaching and Drug Testing  01:27:17 Insulin Resistance Myths  01:32:30 Social Media Arguments01:34:38 Trenbolone and Kidney Concerns  01:39:30 Smart Drug Choices in Bodybuilding  01:49:55 Living In Thailand01:56:35 HGH Timing 02:06:30 Tirzepatide vs. Retatrutide  02:12:00 Prescriptions and Traveling02:16:58 Reversing LVH Growth  02:22:42 Estradiol Levels on Cycle  02:27:04 Anabolic Synonymous Shutdown02:30:45 Classic Physique Drug Use 02:33:40 Life Updates and Fatherhood

Olympian in 212 AND Classic goes to Olympia again ‪@Durrah1‬ ‪@thedurrah‬ The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro: Mahmood's Journey00:02:10 - Son's Inspiration to Compete00:05:22 - Training and Prep Strategy00:09:08 - Transitioning To Classic00:15:35 - Carb-Up and Peak Week Tactics00:20:15 - Self-Coaching and Cheat Meals00:23:47 - Diet Hacks and Cravings00:24:58 - Estrogen and Cycle Management00:27:09 - Son's Reaction and Viral Moment00:29:47 - Overcoming Defeat and Rebirth00:33:42 - Mental Health and Dopamine Struggles00:43:25 - Celebrity Mental Health Insights00:45:29 - Chasing Dopamine and New Passions00:47:34 - Finding Peace and Purpose00:49:14 - Shrinking the Waist for Classic00:51:53 - Waist Trainer and Vacuum Techniques00:55:59 - Diet and Calorie Management00:58:23 - Carb Cycling for Leg Growth01:00:15 - Pumping and Rice Cake Hacks01:02:25 - Diuretics and Post-Prejudging Meals01:04:01 - Cycle Simplicity and Shrinking Down01:09:25 - Coaching and Cycle Mistakes01:11:33 - Weight Cutting Struggles01:20:29 - Redcon1 Loyalty and Community01:21:51 - Mustache Vibes01:24:40 - Daily Diet Breakdown01:27:00 - Advice for Young PED Users01:30:37 - Bloodwork and Health Monitoring01:33:22 - Managing Prep Fatigue and Cardio01:34:06 - Sleep Struggles and UARS Treatment01:38:11 - Fat Burners and Receptor Refresh01:39:50 - Olympia Game Plan01:42:40- Insulin Sensitivity and GH Timing01:49:48 - First Cycle Stories01:59:55 - Prize Money in Bodybuilding02:00:34 - Classic vs. Open Prize Money02:02:29 - Boosting Classic with Bigger Checks02:05:34 - Open Bodybuilding's Freak Factor02:07:01 - Men's Physique and Audience Draw02:08:52 - Separate Men's and Women's Olympia?02:10:29 - Final Message to the World

The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:Watch: https://youtu.be/QgvADjybQCw[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:02:22 - Podcasting & Bodybuilding Origins00:03:37 - Choosing Engineering Over Bodybuilding00:05:19 - Transition to Medicine & Grad School00:06:28 - The Layers of Medicine00:07:41 - Supplements in Preventive Healthcare00:10:35 - Dr. Trevor's Main Focus Now00:15:06 - How to Use PubMed & Read Research00:17:14 - Red Meat & Misinterpreted Studies00:19:59 - Bodybuilding & Cardiovascular Health00:23:04 - Walking, Cardio & Blood Sugar Control00:26:25 - Steps vs Intense Cardio in Prep & Off-Season00:29:32 - Prioritizing Recovery Over Hardcore Work00:31:10 - New Era of Fitness & Proactive Health00:32:33 - Ferrari Analogy: High Performance Needs More Recovery00:36:42 - Monitoring Blood Pressure Accurately00:38:41 - Being Honest with Your Doctor00:41:18 - Tests & Process for Heart Health00:43:00 - Anti-Inflammatory Diet Basics00:45:34 - Carnivore Diet & False Attributions00:47:01 - Best Diet = Lean Proteins + Veggies + Walking00:51:06 - Gut Microbiome's Role in Health00:52:18 - Processed Sugar vs Natural Sugar00:54:06 - Sugar's Drug-Like Effects on the Brain00:57:35 - Supplements For Heart Health01:01:24 - Advanced Organ Support Supplements01:02:54 - Arachidonic Acid Explained01:05:40 - Fast Metabolism and Risks01:08:01 - Stress, Recovery & Longevity01:09:56 - Health Is a Journey, Not a Destination

PhD in synthetic chemistry, the Product Formulator for Supplement Needs, and fitness industry renowned Pharmacologist for his no-nonsense approach in bodybuildingThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com2:19 Bodybuilding Pharmacology and Dosing4:53 Brain Health and Long-Term Risks7:29 Muscle Building and Genetic Factors10:03 Cholesterol and LDL Impacts12:14 Podcast Setup and Equipment Upgrades14:34 Hair Transplant Journey24:23 Hair Loss Causes and Treatments34:59 Post-Transplant Recovery and Rebound39:31 Epigenetics and Muscle Memory43:04 Ethical Questions on Genetic Enhancement45:40 Enhanced Games Debate50:09 Dosing Challenges in Enhanced Sports52:32 Data Collection and Human Experimentation55:16 Genetic Variance and Elite Athletes59:04 Neurodegeneration and PEDs1:07:08 Oxidative Stress in Bodybuilding1:09:37 Sleep and Brain Detox1:18:01 Nutrition for Oxidative Stress1:19:02 Melatonin as an Antioxidant1:21:13 Melatonin Dosing and Effects1:24:51 Melatonin and Sleep Support Supplements1:28:22 Magnesium and Sleep Health1:31:23 Sleep Apnea and Neural Health1:36:30 Frequent Urination at Night1:46:33 Overheating During Sleep1:59:14 Wrapping Up Oxidative Stress2:00:33 Neuron Loss and Neurotransmitters2:02:04 Boosting Brain Health with BDNF2:04:08 Peptides for Neural Growth2:09:14 Oxidative Stress and Supplements2:12:34 Neuroprotection Strategies2:19:56 EMF and Environmental Stressors2:22:12 Mitochondrial Dysfunction and Aging2:24:55 Balancing Oxidative Stress2:28:32 Steroids and Muscle Growth Rates2:38:54 HDL and LDL Control Ancillaries2:41:34 Statins and LDL Oxidation2:47:36 Antioxidants and Plaque Formation2:54:10 Balancing Cholesterol Levels2:58:35 CT Scans for Heart Health3:03:54 Heart Health Supplements3:06:48 Mitochondrial Stack Under 303:16:27 Balanced Diet in Prep3:20:24 Omega-3 and Fish Oil Quality3:23:36 Podcast Wrap-Up

Bryan Moskow: MS Organic & Biochemistry UCF/GT, PhD Student at Georgia Tech, Offseason/Prep Protocols & Hormone OptimizationThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro01:47 - Steroids and PEDs in Bodybuilding  02:59 - Podcast Setup and Audio Talk  03:41 - Science Without an Agenda  04:22 - GLP-1 and GLP-300008:19 - Insulin, Diets, and Brain Health  10:26 - Berberine and Supplement Bioavailability  13:04 - Beta-Alanine and Sodium Bicarbonate  14:59 - Citing Studies and Research Quality  17:32 - Natural Alternatives to Pharmaceuticals  19:34 - Esters and Compound Solubility  21:29 - Brian's Bodybuilding Journey  24:56 - Steroid Protocols and Half-Lives  30:34 - PCT and Fertility Strategies  38:44 - HCG and Male Contraception  41:53 - SARMs and Their Risks  46:08 - GHB as a Supplement  47:40 - GHB Risks and College Stories  50:32 - Prescription GHB and GABA Dangers  51:48 - Long-Term Effects of Sleep Meds 

6th at Olympia (2019), 3rd at Arnold, entrepreneur, husband, and father @stevekucloThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00 - Intro  02:38 - Challenges of Monetizing Bodybuilding  04:09 - Transitioning to Health & Wellness  05:37 - Bodybuilding Prep & Off-Season Strategies  07:46 - Truth About Steroid Dosages  09:19 - Training as the Game Changer  11:15 - Female Trainers & Intensity  12:54 - Early Bodybuilding Journey & Mentorship  16:33 - Building Muscle Over Time  18:59 - Nutrition for Growth vs. Longevity  23:30 - Shifting to Health-Conscious Bodybuilding  26:20 - Maintaining Insulin Sensitivity  29:27 - Optimizing Testosterone Levels  32:20 - Reducing Inflammation with Supplements  37:39 - Glutathione & Detox Support  39:49 - Smarter Supplement Choices  41:03 - B Vitamins for Inflammation & Sleep  43:10 - Science-Based Training & Apps  45:56 - When to Retire from Bodybuilding  50:40 - Health Markers to Monitor  53:37 - Genetic Testing & Alzheimer's Prevention  56:38 - Brain Health & Mental Stimulation  58:20 - Journey into Bodybuilding & Firefighting  1:02:22 - Building a Fitness Business  1:08:56 - Managing Allostatic Load  1:11:16 - Stress & Anxiety in Competition  1:13:51 - Pushing Limits as a Firefighter  1:15:47 - Early DC Training Days  1:17:14 - Evolution of Training Methods  1:19:50 - Balancing Intensity & Smart Lifting  1:21:16 - High-Volume Heavy Training  1:23:27 - Science vs. Bodybuilding Methods  1:26:22 - Off-Season Testosterone Strategy  1:31:53 - Health-Focused Bodybuilding  1:32:56 - Favorite Bodybuilding Show  1:34:32 - Comeback & Boxing Plans  1:36:01 - Regenerative Medicine Tips  1:37:35 - Genetics & Strength Secrets  1:39:51 - Craziest Pre-Contest Cycle  1:41:32 - Project Super Heavyweight  1:43:57 - Top 5 Training Exercises 1:45:26 - Toughest Firefighting Moments  1:47:07 - TRT Plus Approach  1:50:28 - Low-Dose Transformation  1:52:57 - Dealing with Online Haters  1:54:01 - Hair Loss & Restoration  1:57:03 - Time Management Tips  1:59:01 - Life-Changing Final Message  2:02:11 - Thanks  

Olympian, 6x IFBB Pro Champion, & best of all Chris Bumstead's brother in lawThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro  03:02 - Switching to Patrick & European Secrets  11:03 - Back-to-Back Competing  20:18 - Minimal Water Manipulation & Sweating on Stage  22:35 - Nick and Derick  39:57 - Iain on Rebounds  49:51 - Iain Almost Quitting Bodybuilding and Meeting Melissa  1:05:04 - TREN  1:12:51 - Iain's Relationship with Compounds Throughout His Career  1:16:49 - Different Training Methods & Iain's Opinion  1:34:58 - GLP-1s  1:48:51 - How People Look vs. Their Personalities  2:00:27 - Coaching Chris Bumstead  2:14:53 - Iain's Best Body Part  2:26:46 - Breakup Advice for Bodybuilders  2:27:56 - Bodybuilders' Fertility  2:31:57 - HCG for Fertility  2:34:21 - Growth Hormone  2:39:45 - Iain's Best Offseason  2:44:31 - Offseason Gear Discussion  2:52:13 - Most Bodybuilders Having Girls & Iain's Preference&

Brandon Eisenlauer, aka  @BiohackingUThe Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 – Intro08:28 – Neuro-toxicity of popular PEDs (19-nors, Tren, etc.)11:42 – Brain-basics: Neuro-steroid support16:18 – Dopaminergic Life & Consequences21:32 – Real Risk of Bodybuilding, Rest & The Right Way27:04 – Managing Mental Stress: Meditation & Mindful Break38:30 – Gen Z, Motivation Gaps & “Just Go Live Life”41:17 – Independence & Growth42:46 – Psychedelics & Neuroplasticity43:45 – Hustle Culture vs Balance46:40 – Cultural & Political Extremes48:40 – Finding Balance in Bodybuilding52:19 – Conscientious Growth53:50 – Brain Protection Strategies57:01 – Serotonin & SSRI Benefits58:33 – Cholinergic, Sleep Support & GABA System1:03:30 – SSRIs Stigma & Pharma Bias1:12:45 – Best Cycle Principles1:19:38 – Pharmacology Caveats & Nuance1:25:25 – Finding Reasons Is Hard & Adaptation1:27:52 – Mitochondrial & Estrogenic Peptides1:36:14 – Stimulant Cycling Strategy & Risks1:47:10 – Injectable Amino Blends1:52:17 – Peptide Safety & Cancer1:57:36 – Skin Health & Peptides1:59:46 – The Final Question

The first Temu chat.The Bodybuilding-friendly HRT Clinic - Get professional medical guidance on peptides AND optimizing your health as a man or bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com

3rd Place At Detroit Pro next to Wesley Vissers and Matt Greggo, Olympian Classic IFBB Pro Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com

How digestive health can ruin your physique & quality of life w/ Austin StoutJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Start of Gut Health02:20 Protein Digestion and Overeating05:10 High DHT Doses in Bodybuilding08:00 Genetics and Drug Dosages11:30 Social Media vs Real Life Knowledge14:00 Bodybuilders Eating Too Much Protein?18:00 Digestion Issues from High Protein22:00 Nutrient Deficiencies in Bodybuilding26:00 Magnesium Deficiency Explained30:00 Bloodwork Tips: Alkaline Phosphatase34:30 Anemia, Iron, and Lactoferrin39:00 How to Fix Low Iron Safely43:00 Electrolytes and Muscle Function46:30 Adrenal Fatigue and Cortisol Levels50:00 Adrenal Health and Blood Markers53:00 How to Recover from Burnout57:00 Managing Allostatic Load01:00:00 Psychological Stress and Training01:01:53 Stress & Mindset in Bodybuilding01:07:58 GLP-1 Peptides & Weight Loss01:15:24 Obesity & Hunger Hormones01:26:39 Autoimmune & Gut Health01:33:46 Fruits, Veggies & Digestion01:43:11 Insulin & Growth in Women01:50:20 Metabolic Damage & Prep Struggles01:54:28 Longevity in Bodybuilding01:56:22 Final Thoughts & Sign-Off

“The Martian”  the current 4th place at Mr. Olympia and Prague Pro Champion. One of the youngest stars in open bodybuilding. Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Intro & Bodybuilding Journey  00:00:27 Training & Recovery Secrets  00:01:06 PEDs & Gear Talk  00:02:13 Honest Message on PEDs  00:03:59 Staying Healthy as a Pro  00:08:07 Diet & Digestion Struggles  00:12:11 Training Like a Beast  00:18:58 Genetics & Recovery  00:31:25 From Pharmacy to Bodybuilding  00:54:10 Sleep & CPAP Life  00:57:46 Supplement & Health Protocols  00:59:18 Melatonin: Super Antioxidant?  01:01:00 Gut Health & Digestion  01:02:55 T3 vs. T4: Thyroid Secrets  01:10:34 Steroid Side Effects & Lessons  01:14:24 Why Orals Aren't Worth It  01:17:33 Rest & Recovery Hacks  01:20:14 Sleep = Skeleton Face?  01:23:27 Confidence & Olympia Mindset  01:25:39 Downsides of Fame  01:28:50 Social Media & Business  01:31:51 Bob vs. Nick Drama  01:34:39 Pittsburgh Pro Goals  01:53:23 Worst Cycle Experience  02:00:47 Stress-Free Gains  02:14:38 Chris Bumstead Rivalry  02:23:18 Weed & Bodybuilding  02:31:31 Villain to Fan Favorite  02:37:04 Final Message

Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaWatch it: https://www.youtube.com/watch?v=6Ihq4tIzyS8&t=5618sRP Hypertrophy Training App: rpstrength.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro02:00 Genetics & Steroid Response06:10 Building a Family While Competing09:45 Health After Bodybuilding13:00 The Reality of TRT After Pro Life17:00 Testosterone and Brain Chemistry21:00 How to Survive the Health Phase25:00 Bloodwork Isn't Everything30:00 Estrogen: More Than a Number35:00 Glutathione & Antioxidants40:00 Liposomal Supplements Are OP44:00 Genetic Testing for Bodybuilders49:00 Personalized Medicine is the Future54:00 Fast vs Slow Steroid Metabolizers58:00 Drug Dosage ≠ Death Risk01:02:00 The Oral Steroid Blind Spot01:04:30 When Should You Start PEDs?01:10:00 A Warning for the Younger Guys01:13:00 What's the Right Age to Begin?01:16:00 Final Thoughts01:32:23 Sleep Troubles & Insomnia Hacks01:35:00 Biochemistry of Falling Asleep01:38:00 Dopamine, Serotonin & Brain Dumping

Svein Falzon @genet1cAnomaly, from world's biggest 20 year old to now 2 years later… Just because we see an online persona, doesn't mean we know who someone may really be in person. While meme'd the biggest 20 year old by Larry Wheels and others… Whatever it was that got him to use ped's, with others realizing his potential before hand and with absolutely nothing to lose, committing his everything to this path seems the only light at the end of the tunnel to make enough money to get his mom and himself out of this hell hole and achieve his dreams at the same time.Watch it: https://www.youtube.com/watch?v=lR7YRb0DBhIJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro02:10 - The Masked Bodybuilder Origin Story07:04 - Social Media & Fitness Industry Growth12:01 - Training & Physique Development18:40 - Back & Hamstring Growth Struggles22:32 - Squat Form & Hip Mobility Issues31:22 - From 100K to 1.5M Followers34:35 - The Mindset of Never Being Enough40:07 - Health, Steroids, and Responsible Use45:55 - Growing Up Poor & Family Motivations50:16 - Sam Sulek's Pro Card & Modern Bodybuilding56:10 - Fake Beefs for Engagement1:02:11 - Competing in Bodybuilding: Future Plans1:04:20 - Acne, Blood Pressure & Health Protocols1:11:07 - Ultimate Life Goals1:12:00 - Svein's Mom and Why He Continues Bodybuilding1:15:12 - Finding the Right Coach1:20:18 - Favorite Steroids & Offseason Compounds1:25:02 - The Truth About the Togi Beef1:27:12 - Gear selection1:28:27 - Svein's Final Message#podcast #mentalhealth #humanoptimization #holistic #health #hrt #connection #story #discipline #fitness #ifbbpro #npc #bodybuilder #bodybuilding #selfimprovement #workout #gym #nutrition #mensphysique #classicphysique #love #discipline #relationships #tren #workout #gym #trt #hormones #discipline #gear #steroids #bodybuilding #peptides fitness trt hormones workout gear trensparent

Coach at J3U (John Jewett's coaching) and Ireland's 1st Olympian. One of my personal favorite podcast conversations yetWatch it: https://youtu.be/nLe7VIelyscJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro02:59 Being A Good Coach04:05 How Darren Got Into J3U Coaching11:13 What Sparked Darren's Bodybuilding Journey15:20 Getting The Pro Card24:44 Not Giving Up Pays28:10 Darren's Struggles and Focusing On Bodybuilding42:30 PEDS' Effects On Mental Health48:45 Modern Male Struggles58:11 Right Amount, Right Results1:08:16 Natty Look or Not1:17:50 Focusing On The Bigger Picture1:26:41 Long Covid1:36:33 Form & Intention Is The Key1:45:10 Darren & Estrogen - Strange Relation1:48:03 Any Regrets?1:48:47 The Final Question#podcast #mentalhealth #humanoptimization #holistic #health #hrt #connection #story #discipline #fitness #ifbbpro #npc #bodybuilder #bodybuilding #selfimprovement #workout #gym #nutrition #mensphysique #classicphysique #love #discipline #relationships #tren #workout #gym #trt #hormones #discipline #gear #steroids #bodybuilding #peptides fitness trt hormones workout gear trensparent

Very young IFBB Pro & a man I truly believe will be the Classic Mr. ⭕️ someday Watch it: https://youtu.be/7OWj5Dw1H_cJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro  01:07 Start  03:02 How Jack Got Into Bodybuilding  12:00 Lex Little's Rants  21:37 Mind and Body  22:42 Jack's Stage Weight & Carbing Up  28:22 Last Few Weeks Leading Up to a Show  36:40 Jack's Potential & Secret Behind Great Shape  43:48 The Problem with Legs  48:54 Bro Science vs Science Heads - Training Styles  53:03 Is Bodybuilding a Skill?  57:30 Jack's Genetics  1:05:46 Why Bodybuilding?  1:11:04 Jack's Insane Back & Lats  1:17:11 Realizing That You Are Competing Against PED Guys  1:28:47 Pro Card Won't Get You Followers  1:36:02 Expectations & Journey  1:43:54 Jack's Preferred Cycles  1:52:42 Don't Maingain  1:56:16 The Ending Question  #podcast #mentalhealth #humanoptimization #holistic #health #hrt #connection #story #discipline #fitness #ifbbpro #npc #bodybuilder #bodybuilding #selfimprovement #workout #gym #nutrition #mensphysique #classicphysique #love #discipline #relationships #tren #workout #gym #trt #hormones #discipline #gear #steroids #bodybuilding #peptides fitness trt hormones workout gear trensparent

Hussein and I debate his natty status and depressionWatch it: https://youtu.be/7OWj5Dw1H_cJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00:00 Jared and Dr. Mike  00:04:13 Greg  00:12:35 Hussein's History  00:15:23 Gaining Weight  00:17:32 Hussein Competing  00:21:40 Me Getting Into Gear  00:25:37 Pushing The Message on Social Media  00:28:07 Parenting vs Gear  00:30:17 Promoting Steroids  00:34:08 Why Did Hussein Compete?  00:44:13 Competing Again?  00:45:37 Young Hussein  00:51:52 Committing To Bodybuilding  00:54:10 Gear is not everything  01:00:06 Post Competition Experience  01:08:51 Eric Janicki  01:16:34 Hussein is most anxious about  01:21:37 Hussein's Philosophy On Life  01:27:43 My view about fulfillment  01:30:18 Depression  01:51:45 Relationships  01:55:26 Hussein's Bag's Content Before a Competition  02:03:13 Looks Natural To Me  02:07:49 Balancing Social Media While Bodybuilding  02:15:59 How Hussein Started Out  02:19:44 Don't Underestimate Yourself  02:25:43 Best Natty Stack  02:30:25 Hussein's Diet  02:34:48 The Final Question  

Truth about steroids - The largest convicted steroid dealer in US history. Ryan is a biochemist, who tailored his degree, and the last 20 years of his life, to understanding and studying these compounds with over two decades of experience in the hormone industry. He discusses his story, problems with UGL and how steroids and the industry have changed in the last decade.Watch it: https://youtu.be/SsIC4dQQxyM?si=NpEjXAaDsykN2Wz2Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 Intro  03:19 Biggest Fear of a Solo Podcaster  08:22 Ryan's Steroid Empire  08:50 Ryan Guiding People  10:00 Ryan's Early Life & Struggles  15:35 How Ryan Got into Studying Steroids  17:22 Ryan's First Source  19:33 Were Steroids Better Back Then?  22:52 How Ryan Got into Online Selling  29:54 Ryan's Business Model Back Then  33:27 Ryan's Routine When the Empire Was Rising  36:38 Helping People  38:49 Growing The Business  46:00 Reviews that Ryan Got  49:09 The Hardest Compound to Make  53:10 Making His Own Stuff  55:33 How Ryan Got Caught First  1:00:06 Operation Cyber Juice  1:07:55 Prison And People  1:12:42 Government's View on Substances Then vs Now  1:17:52 Politics Behind Steroids  1:26:46 Big Pharma, Lobbyists & Hidden Agendas  1:28:43 Testosterone is a Cure?  1:35:43 How Bad Science Shaped Public Perception  1:40:10 Different People, Different Results  1:42:58 Self-Centricity  1:49:34 Faking is Not Needed Anymore  1:53:49 Would Ryan Do It Again?  2:00:52 Keep it Simple  2:04:02 Do Lot of People Secretly Take PEDs? Ryan's View  2:05:43 Most Selling Compound After Test  2:07:15 Higher Doses, For Longer Time = Issues?  2:11:14 Heart Murmurs and Compounds  2:12:52 Preventing Hypogonadism  2:17:05 Prison Life  2:17:37 The Problem with The Justice System  2:20:33 Benzyl and Solvents in UGL Gear  2:23:40 The Final Question  2:25:17 The End  

2x Olympian, MP IFBB Pro, host of men's physique radio, and owner of @manifest_competitionwear. A man with a firey passion for men's physique https://youtu.be/H8rXvh5q0dQJoin the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.comTimestamps:00:00 - Intro 02:12 - Alex's Work-Life Balance, Then vs Now  04:11 - Smoking and Consequences  04:44 - How Alex Controlled Smoking  09:24 - Weed  11:23 - Controlling Testosterone Usage  14:46 - How Alex Got Into Bodybuilding  19:53 - Health Complications That Alex Experienced  23:23 - Competing and Off-Seasons of Alex  25:40 - Old School vs Modern Bodybuilding  31:05 - Alex's Fall  40:13 - Taking Off Phases  48:44 - More Receptors, More Gain  52:54 - Supplements and Medication to Keep Health in Check  59:02 - Importance of Patience in Bodybuilding  1:06:01 - How Alex Got Into Coaching  1:10:13 - Shizzy  1:10:51 - Natty vs Enhanced  1:20:04 - Audience Questions  1:23:19 - Alex Getting Healthy  1:28:57 - Intense Training  1:33:11 - Leaving the Day Job to Become a Coach & Entrepreneur  1:35:02 - Where Do You Store Your Syrup? (Joke)  1:37:47 - Mentality of a Bodybuilder  1:41:05 - Alex's First Cycle  1:43:13 - What Made Alex Get Into Bodybuilding  1:44:41 - Natty People vs Enhanced People  1:47:55 - The Ending Question  #podcast #mentalhealth #holistic #health #hrt #story #discipline #fitness #ifbbpro #npc #bodybuilder #bodybuilding #workout #gym #nutrition #physique #classic

3-in-1 Podcast Special. So much went wrong when trying to put this together. I appreciate you guys' patience for the extra time it took us to finally get this up.I respect any bodybuilder that has put in years of hard work, and is a good person to others. I commented some associated apologies and disclaimers on the YouTube video.Join the Bodybuilding-friendly HRT Clinic - Get professional medical guidance on your health as a bodybuilder:[ Pharma Test, IGF1, Tesamorelin, Glutathione, BPC, Semaglutide, Var troche, etc]https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story  https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'NYLE' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program:  https://www.nylenaygafitness.com00:00:00 - Intro00:07:00 - Jared's Personal Stories and Experiences00:09:14 - Different Opinions Around Tren00:13:42 - Jared's Experience With Lasix00:19:55 - Body Fat And It's Effect On Competing00:23:13 - How Jared's Journey Started00:29:30 - Training and Nutrition Tips00:34:34 - Jared's Experience In India00:35:04 - Anabolics' Uses & Downsides00:36:34 - Childhood Experiences and Uprising00:38:16 - Mental Health & Its Importance00:44:30 - Competing in Bodybuilding00:51:04 - Jared's future plans00:57:12 - Jared's Transformation Journey01:00:05 - Coaching Philosophy and Emotions01:03:35 - Kyle joins01:06:51 - Future Coaching Plans and Goals01:11:50 - How Kyle Met Nick01:15:33 - Kyle's Coaching With Matt01:25:00 - Nick Walker's Training Style Then vs. Now01:29:20 - Importance Of Change01:34:32 - Genetics Aspect Of Bodybuilding01:44:35 - How IFBB Focusing On Shape Affects01:50:23 - The State of Online Coaching01:52:57 - Coaching Dynamics and Pressure02:01:30 - Nutrition & Training Insights02:05:04 - Q&A with Kyle & Jared02:10:41 - Final Question With Jared02:12:26 - The Journey of a Bodybuilder02:20:00 - The FU Family02:21:15 - How Bodybuilding Started For Kyle02:33:25 - How Diet And Training Has Changed02:43:51 - PED's one has the most issues with02:52:00 - Taking too much gear02:55:17 - Potential of Anomalies Like Anton03:01:58 - Importance of Programming in Natural vs Enhanced03:08:45 - How Does It Feel To Coach Popular Clients03:17:45 - Ending Question #podcast #mentalhealth #holistic #health #hrt #story #discipline #fitness #ifbbpro #npc #bodybuilder #bodybuilding #workout #gym #nutrition #physique #classic