Podcasts about Methionine

In this episode of The Dairy Podcast Show, Dr. Jimena Laporta from the University of Wisconsin Madison and Dr. Danielle Sherlock from Adisseo discuss how methionine supplementation may help dairy cows better manage heat stress. They explore its effects on milk components, liver and mammary function, placental development, calf growth, and the potential long-term impacts on productivity across future generations. Listen now on all major platforms!"Heat stress affects more than feed intake, directly influencing mammary gland activity, metabolism, and overall physiological function." - Dr. Jimena LaportaMeet the host & guests:Dr. Danielle Sherlock is Global Ruminant Innovation and Customer Success Manager at Adisseo. With advanced training in animal sciences and dairy cattle physiology, her work focuses on nutritional strategies that support dairy cattle health, productivity, sustainability, and resilience during environmental challenges.Dr. Jimena Laporta is an Associate Professor of Lactation Physiology at the University of Wisconsin Madison. Her research focuses on heat stress, mammary gland biology, fetal programming, and how prenatal and early life conditions influence health, productivity, and performance in dairy cattle.Dr. Katie Boesche is a Dairy Technical Manager at Adisseo. With expertise in ruminant nutrition, mammary biology, and dairy cattle physiology, she works with producers and industry partners to support practical nutrition programs that improve herd performance and long-term productivity.Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(00:33) Introduction(01:53) Methionine and heat stress(05:41) Cow performance responses(14:49) Heifer development effects(17:55) Placental nutrient transport(25:44) Nutrition recommendations(27:34) Final QuestionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo

Swapping animal protein for plant protein may help women lose weight after menopause. Dr. Neal Barnard joins Chuck Carroll on The Exam Room Podcast to discuss a new study he co-authored that finds replacing animal protein with plant protein may be a powerful strategy for weight loss in postmenopausal women. The study found that total protein intake did not need to change. Instead, the source of protein appeared to matter most. As women reduced animal protein and increased plant protein from foods such as soybeans, beans, and grains, they experienced significant weight loss. Dr. Barnard explains why not all protein is created equal, how plant protein may affect metabolism differently than animal protein, and why this could be especially important for women after menopause.

On this episode of the Feeding Fumbles & Fixes series of Beyond the Barn, host Katy Starr and Dr. Kelly Vineyard, PhD equine nutritionist, discuss some helpful tips to getting a healthy, shiny coat for your horse, including: Why some horses never achieve that healthy coat shine despite excellent grooming and care Why two horses consuming the same amount of protein in their diets can have dramatically different coat quality The surprisingly small dietary adjustment that horse owners have relied on for decades to help enhance coat shine If you've ever wondered why some horses seem to glow while others look dull despite your best grooming efforts, this episode will help you look beyond brushing, bathing and conditioning to better understand the nutritional foundation of a healthy, shiny coat.

This episode originally aired as #597 on 12/20/25 and we are bringing it to you again! On this episode of Vitality Radio, Jared breaks down amino acids—what they are, how they work in the body, and how to supplement them strategically for muscle health, recovery, fasting, metabolism, and healthy aging. He explains the difference between essential amino acids, branched-chain amino acids (BCAAs), collagen, protein powders, and whole-food protein, and clarifies when each one makes the most sense. Jared also walks through practical use cases, including workout performance, muscle preservation during fasting, age-related muscle loss, and supporting lean mass during calorie restriction—without hype! If protein goals, collagen, amino acids, or fasting protocols have been confusing, this episode delivers clear, practical guidance you can actually use.Products:Vitality Nutrition Essential AminosRebuild+ Functional Bone Broth Protein Additional Information:#573: Protein Showdown: Whey, Collagen, Bone Broth, Plant Based, and Beyond!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

This podcast details the physiological importance of **methionine**, an **essential amino acid** that humans must obtain through their diet. It serves as a critical **building block for protein synthesis**, acting as the starting signal for translating genetic code in all living organisms. Beyond its role in structures, it functions as a **precursor to cysteine** and generates **S-adenosylmethionine**, a vital molecule used for transferring methyl groups in biological reactions. The podcast also explains that while methionine can be recycled from **homocysteine**, this process requires **Vitamin B12 and folate** to function correctly. Consequently, a lack of these vitamins can lead to an unhealthy **accumulation of homocysteine**, which is linked to a higher risk of **cardiovascular disease**.

This week's stories: Healthy Diets That Offset "Bad Genes" A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol. • Sources: -https://www.science.org/doi/10.1126/sciadv.ads7559 -https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179 -https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity Micro-Habits in Sleep, Activity, and Diet That Extend Life Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four — we're talking minutes per day — cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation. • Sources: -https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424 -https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502 -https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure New research shows that reducing sulfur amino acids — methionine and cysteine, found heavily in certain animal proteins — triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too • Sources: -https://elifesciences.org/reviewed-preprints/108825v2 -https://www.nature.com/articles/s42255-025-01297-8 -https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review Tyrosine and Lifespan: What the Data Says for Men A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men — with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically • Sources: -https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx -https://www.eurekalert.org/news-releases/1105915 -https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress — even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking. • Sources: -https://www.sciencedaily.com/releases/2024/07/240718124709.htm -https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds -https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers -https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387 All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026 Thank you to our sponsors! -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.comResources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 0:18 - Story #1: Diet vs. Genetics 2:14 - Story #2: 1% Better Every Day 4:26 - Story #3: Sulfur Amino Acids & Fat Loss 5:55 - Story #4: Tyrosine & Longevity 7:58 - Story #5: Doomscrolling & Aging 10:00 - Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On this episode of Vitality Radio, Jared breaks down amino acids—what they are, how they work in the body, and how to supplement them strategically for muscle health, recovery, fasting, metabolism, and healthy aging. He explains the difference between essential amino acids, branched-chain amino acids (BCAAs), collagen, protein powders, and whole-food protein, and clarifies when each one makes the most sense. Jared also walks through practical use cases, including workout performance, muscle preservation during fasting, age-related muscle loss, and supporting lean mass during calorie restriction—without hype! If protein goals, collagen, amino acids, or fasting protocols have been confusing, this episode delivers clear, practical guidance you can actually use.Products:Vitality Nutrition Essential AminosRebuild+ Functional Bone Broth Protein Additional Information:#573: Protein Showdown: Whey, Collagen, Bone Broth, Plant Based, and Beyond!Visit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Dr. Steve Feldman on THE HEDONIC TREADMILL -L-methionine for warts - with Dr. Shreya Sreekantaswamy! - Neck stretches for scalp dysesthesia - Extragenital lichen sclerosus -Pediatric androgenetic alopecia - Learn more about the U of U Dermatology ECHO model!physicians.utah.edu/echo/dermatology-primarycareWant to donate to the cause? Do so here!Donate to the podcast: ⁠uofuhealth.org/dermasphere⁠Check out our video content on YouTube:⁠www.youtube.com/@dermaspherepodcast⁠and VuMedi!: ⁠www.vumedi.com/channel/dermasphere/⁠The University of Utah's DermatologyECHO: ⁠⁠physicians.utah.edu/echo/dermatology-primarycare⁠ -⁠ Connect with us!- Web: ⁠⁠dermaspherepodcast.com/⁠⁠ - Twitter: @⁠DermaspherePC⁠- Instagram: dermaspherepodcast- Facebook: ⁠www.facebook.com/DermaspherePodcast/⁠- Check out Luke and Michelle's other podcast,SkinCast! ⁠⁠healthcare.utah.edu/dermatology/skincast/⁠⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at:- ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge)- ⁠⁠www.levelex.com/games/top-derm⁠⁠ (A free dermatology game to learn more dermatology!

Dr. Hristov gave a webinar titled “Histidine: a limiting amino acid for dairy cows” on March 4, 2025, and joins the podcast in this episode for a deeper dive into the topic. Panelists introduce themselves and give some background on their interest in histidine (00:52)Dr. Hristov gives an overview of his webinar presentation, touching on some of the first research projects that showed lower protein diets resulted in no change in plasma methionine, but a decrease in plasma histidine. When dietary protein decreases, the cow relies more on microbial protein to meet her needs. Histidine content is about 20% less than methionine content in microbial protein. He also notes there are some short-term reserves of histidine in the body, so short-term studies may not show a histidine deficiency when indeed there is one. (7:08)Matt gives some perspective as a consulting nutritionist about the importance of histidine in diet formulation for his clientele. He agrees with Dr. Hristov about the higher requirement for histidine compared to methionine, and he generally formulates diets with 1.1 times more histidine than methionine. (12:38)The panelists share their experiences with the responses observed from providing additional histidine to lactating cows, including milk and component yields and changes in dry matter intake and body condition. They also talk about how muscle loss can mask a histidine deficiency in the short term. (15:43)The panelists discuss the challenges in determining histidine requirements and finding reliable sources of highly bioavailable histidine. (24:04)Why is rumen-protected histidine not commercially available? Clay explains it is due to the high cost of histidine. There are no feed-grade sources, and using human-grade sources is cost-prohibitive. Dr. Hristov notes swine nutritionists are starting to pay more attention to histidine, which might bring the cost down if demand increases. Matt notes aquaculture is also interested in histidine. (33:58)Matt comments that increasing fat content can be problematic for cheese plants. He sees increasing milk protein yield may be the next frontier of dairy nutrition and histidine might play an important role. The panel discusses the role milk pricing has played in the increased fat content. (37:32)The panel discusses what other amino acids might be important in dairy nutrition as research continues. They also touch on methane mitigation and reducing methane intensity per unit of milk. (43:45)Panelists share their take-home thoughts. (54:31)View Dr. Hristov's webinar on this subject by visiting https://balchem.com/anh/podcasts-webinars/histidine-a-limiting-amino-acid-for-dairy-cows-2/Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

My guest today is Dr. Kenda Rigdon. Dr. Rigdon is a microbiologist with a PhD in microbiology and virology from the University of Alabama at Birmingham. Drawing from her expertise, she explores how the gut's microbial ecosystem—comprising bacteria, yeast like Candida and Malassezia, and other microbes—interacts with genetic and epigenetic factors to influence Autism. Dr. Rigdon highlights the critical role of the birthing process, particularly how vaginal delivery seeds a newborn's gut with beneficial microbes like lactobacillus, setting the stage for healthy development in the first three years. She also delves into how yeast overgrowth, nutrient competition (e.g., for tryptophan), and environmental factors like manganese and glyphosate exposure can disrupt this delicate ecosystem, potentially exacerbating autism-related symptoms.Dr. Rigdon shares insights into the surprising links between melanin, Neanderthal DNA, and Autism. She discusses how specific genetic mutations, such as MTHFR and PAI1, can intersect with Autism. Additionally, she connects melanin production—potentially influenced by gut yeast like Malassezia—to neurological health, drawing parallels with conditions like Parkinson's. By viewing the gut as a dynamic ecosystem shaped by birth, diet, and early development, this episode offers a fresh perspective on Autism's microbial roots and practical implications for health, urging listeners to reconsider modern birthing practices and dietary choices in fostering a balanced gut microbiome.Dr. Rigdon X https://x.com/KendaRigdonDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Dr. Kenda Rigdon1:14 Journey into Microbiology4:08 The Gut's Ecosystem8:21 Genetics, Autism, & The Microbial Connection13:08 MTHFR & PAI1: Homocysteine, Methionine, Folate20:21 The Role of Yeast in Health & Disease; Serotonin, Candida26:39 The Fight for Tryptophan31:14 Impact of Birthing Method on Gut Health (!)33:13 Modern versus Evolutionary Births, Breastfeeding; Oxygen, Acidity, PH37:15 Melanin, Cell Protection, Neanderthal DNA, Autism40:46 Neuromelanin; Biological Energy, Melanocytes43:20 Neanderthal's & Modern Disease & Environments47:23 Microbes in the Brain53:21 Manganese & Gut Health58:22 Gut-Brain Connection & Microbial Balance01:03:19 Early Gut Health & Development; Modern Insults01:07:21 Future Direction in Gut Health & Kenda's Passion & LoveX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

Getting 50 grams of protein per meal may be the single most underrated biohacking protein strategy for muscle growth, metabolism, and longevity. In this episode, you'll discover why animal protein vs vegan is not a fair match biologically, how hitting the leucine threshold activates mTOR for longevity, and why muscle is the most overlooked organ of aging. This is must-listen content for anyone optimizing human performance, hacking metabolism, or reversing muscle loss with food. Host Dave Asprey is joined by Dr. Gabrielle Lyon, a pioneer in Muscle-Centric Medicine®, functional medicine expert, and top authority on clinical nutrition for longevity. Trained by protein researcher Dr. Donald Layman, she brings decades of expertise on how to use high-protein diets, amino acid science, and functional medicine to radically improve healthspan and brain optimization. Dr. Lyon works with everyone from special operators to aging patients, making her one of the most trusted voices in anti-aging diet strategies. Watch this channel on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn: • Why 50g of protein per meal matters more than total daily intake • How mTOR and longevity are misunderstood in mainstream nutrition • Why protein vs plant protein debates ignore hard biological data • How leucine thresholds determine muscle activation • Why fasting and protein cycling beats low-protein veganism • How ketosis and protein intake impact metabolic health • Why many on a vegan diet experience sleep issues, hormone crashes, and reduced resilience • How functional medicine podcasts like this one reveal the truth about aging and muscle loss • What happens clinically when patients switch to a high-protein diet • How to use supplements, nootropics, and protein hacks to enhance neuroplasticity, mitochondrial energy, and total body performance If you've ever asked “what's the best protein for muscle growth?” or “how does protein affect metabolism in aging?”, this episode gives you evidence-based answers from the front lines of clinical nutrition. This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you're tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won't hear anywhere else. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! 40 Years of Zen | Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. Resources: • Gabrielle's Website: https://drgabriellelyon.com/ • Gabrielle's IG: https://www.instagram.com/drgabriellelyon/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 Trailer • 0:51 Protein Controversy • 2:38 Leucine • 6:00 mTOR, Methionine, and Protein Synthesis • 9:00 Vegan vs. Carnivore • 16:00 Optimizing Protein Intake & Aging • 22:00 Carbohydrates, Hormones, and Female Health • 28:00 Environmental Impact & Food Sourcing • 34:00 Debunking Plant-Based Documentaries • 40:00 Key Takeaways & Closing Keywords: protein vs plant protein, 50 grams of protein, biohacking protein, mTOR and longevity, animal protein vs vegan, leucine threshold, Gabrielle Lyon, muscle-centric medicine, best protein for muscle growth, anti-aging diet, muscle as organ of longevity, fasting and protein, ketosis and protein, vegan diet risks, optimizing metabolism, high-protein diet, functional medicine podcast, Dave Asprey protein, aging and muscle loss, clinical nutrition for longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Many horse owners focus on choosing the best hay, grain, or supplements, but research shows that when you feed can also impact how well your horse utilizes protein and amino acids.On this episode, co-hosts Dr. Tania Cubitt and Katy Starr and guest Dr. Sara Mastellar, equine nutrition researcher and professor at Ohio State ATI, break down her research on meal frequency and protein metabolism in horses, including:The difference between “just feeding protein” vs. ensuring your horse gets the right amino acidsWhy feeding multiple meals a day can improve your horse's nutrient absorptionSimple, practical ways to adjust your horse's feeding routine for better healthAs Dr. Mastellar mentions, “Observation is central to good horsemanship.” If you've ever wondered whether your feeding schedule is truly working for your horse, this is an episode you don't want to miss!

Have you tried countless topical acne remedies that haven't seemed to work? In this video, I'm going to show you how to get rid of acne fast, naturally! Find out how to get rid of acne overnight in this video. DATA:https://pmc.ncbi.nlm.nih.gov/articles... Today, I'm going to share one of the best acne remedies to help get rid of acne naturally and effectively. I discovered 4 patents that involved sulfur for acne, and I noticed countless sulfur creams on the market. So, what's the deal with sulfur for acne?Many people with acne are deficient in sulfur. Sulfur can help with acne removal because of the following benefits•Decreases inflammation •Increases hydration of the skin•Increases collagen•Helps regulate androgens •Helps regulate insulinGrains, sugar, seed oils, fructose, and alcohol can deplete sulfur. You get small amounts of sulfur from plants like garlic, onion, and cruciferous vegetables, but most of your sulfur comes from protein. Methionine and cysteine are the 2 amino acids that provide you with the most sulfur. After calcium and phosphorus, sulfur is the most abundant mineral in the body, so you need a lot of it!To increase sulfur and get rid of acne, consume the following foods:1. Eggs2. Fish3. Beef4. Lamb5. Cheese6. Organ meatsYou must also avoid sugar and starch, which will block the absorption of methionine and cysteine and decrease sulfur.Try increasing your intake of high-quality animal-based protein to get rid of acne fast. Let me know how it works!

Previously shared as a paid newsletter in May 2024. In previous newsletters, I've addressed many of the more common contributing factors to brain symptoms, including high pyrroles, copper-zinc imbalances, methylation imbalances, candida overgrowth, mast cell activation, mold and other forms of toxicity, and genetic variants, such as COMT and MAOA.Supplements can be needed to address each of these. Medication can also be necessary when treating mold and mast cell activation.But what happens when someone can't tolerate a supplement or medication because it worsens or creates new brain symptoms? Why, for example, could someone have problems tolerating B6 or SAMe or Methionine. Why might someone have problems with folate, niacinamide, glutathione, certain herbal treatments, antidepressants such as SSRIs, probiotics, antifungal medication or binders such as bentonite clay, activated charcoal, chlorella or cholestyramine?In this newsletter, I'll discuss:* Five common reasons a supplement or medication may worsen symptoms.* Specific supplements and medications that are more likely to do this.* How reactions may point to root causes.* Treatment steps that can improve tolerance.There can be a wide range of brain symptoms that can occur when someone is having an adverse reaction, such as fatigue, brain fog, depression, anxiety, agitation, and even psychosis or mania. I'll use “reactivity” to refer to this range of possibilities. While physical side effects can also occur, the focus here will be on brain symptoms.5 Common Reasons Supplements or Meds May Worsen Symptoms1. Immune ReactivityOur immune system is intertwined with our central nervous system. When our body's immune system reacts to a toxin, microbe, injury, or trauma, we can have inflammatory brain and physical symptoms.“Feel Like I'm Reacting to Everything” - Mast Cell ActivationIf someone is experiencing severe immune reactivity, such as mast cell activation, they may react to many supplements and medications, as well as triggers in their environment and stress. The number of triggers can help point to an exaggerated immune response. In my practice, this high immune reactivity is usually driven by mold toxicity.For many with this obstacle, starting very low and slow can prevent reactions. For others, interventions may be needed to lower immune reactivity and stabilize mast cells. This, however, can require certain supplements. For those who can't tolerate those treatments, limbic system retraining programs help calm the immune system so people can move forward more easily.Sensitivity & IntoleranceIt is possible to have immune sensitivity (or even allergy) to a supplement, though I find this less common. Herbal supplements, for example, which are high in salicylates, may cause symptoms in those with salicylate sensitivity. Certain probiotics have bacterial strains high in histamine. This is an issue for those with histamine intolerance.2. Too Much or Too Little Neurotransmitter ActivitySome people with brain symptoms have high neurotransmitter (NT) activity, and some have low. Common NT's include serotonin (5-HT), dopamine (DA), and norepinephrine (NE). I use the term “neurotransmitter activity” because it's not just about the amount of neurotransmitters present; it's also about the amount of receptors present that pick up NTs and remove them from the space between nerve cells.High Neurotransmitter ActivityToo much neurotransmitter activity can cause brain symptoms such as mania, psychosis, agitation, anxiety, panic, obsessions, compulsions, and hyperactivity. Reactions can occur if supplements or medications are given that further increase NT activity.Examples include:* Overmethylation* Slow COMT (involved in clearing DA and NE) and/or slow MAOA (involved in clearing 5HT, DA and NE)A variant on COMT and/or MAOA doesn't mean they are being expressed.What Increases Neurotransmitters?* SSRIs (Selective Serotonin Reuptake Inhibitor) increase serotonin activity* SNRIs (Serotonin and Norepinephrine Reuptake inhibitors) increase serotonin and norepinephrine activity.* Stimulant medications such as Ritalin and Adderall increase dopamine activity* SAMe and methionine increase serotonin and dopamine activityRemember that there can be times when there is a mixed picture, such as when someone is undermethylated and has a slow COMT.Low Neurotransmitter ActivityReactions can occur if supplements or medication decrease the neurotransmitter activity when it is already low. This could look like depression, apathy, fatigue, and brain fog.Examples include:* Undermethylation* Fast COMT (involved in clearing DA and NE) and/or fast MAOA (involved in clearing 5HT, DA and NE). The NTs are getting cleared too fast.What Decreases Neurotransmitters?* Folate, a nutrient that is good for a lot of people happens to be a big problem for many with psychiatric conditions. Most with underemethylation have low serotonin symptoms (depression and/or anxiety). While folate can help methylation, as an unfortunate aside, it can also further lower serotonin activity. Folate is in most multivitamins and B Complex vitamins. To learn more: Undermethylation, MTHFR & The Great Folate Debate.* Niacinamide can lowers DA and NE.Looking closely at someone's symptoms and traits and assessing methylation through bloodwork can help determine if NTs are too high, low, or mixed and what types of treatment to consider.3. Poor Detoxification or Toxic OverloadZincZinc is one of the most powerful tools I use in my work. Some people can easily tolerate it, while others can struggle. Here are some reasons someone may not tolerate zinc.* High copper—Zinc mobilizes copper. Moving too much copper at once can increase copper symptoms (anxiety, anger, hyperactivity, insomnia).* High toxicity—Zinc is a strong antioxidant. It is needed for the genetic expression of one of the most important antioxidants in our body, metallothionein.It took me 8 months to get my dose up to an optimal range, which is certainly not the norm. I unknowingly had significant mold toxicity at the time.When I start someone on zinc, I slowly build it up over 3-4 weeks. For some (like myself), even this is too fast.GlutathioneThis is the other major antioxidant. If someone is having difficulty tolerating it, they may have problems with detoxification and significant toxicity (metals, biotoxins like mold, and chemicals). These can start to be addressed in several other ways.BindersThese include bentonite clay, chlorella, activated charcoal, and cholestyramine. They bind toxins, especially mold toxins, in the GI tract. If they are started too quickly, the toxins they are supposed to remove get stirred up, which stirs up symptoms. When people say they can't tolerate certain binders, they usually weren't started low enough.There are others, but these are the most common in my experience.4. Underlying Microbial or Microbiome IssueB6B6 is very important for brain health. It is needed for making serotonin, dopamine, and GABA. We use it in all the Walsh nutrient protocols to varying degrees. In the last 10 years, we've seen a decrease in B6 tolerance. It's not clear why. I'm including it in this section because the reactivity is suspected to be related to the microbiome. Perhaps in recent years, we have had collective damage to our microbiomes from toxins and rising EMF exposure. We don't know.The good news is that P5P, the active form of B6, is usually well tolerated. In my practice, I rely heavily on P5P. I will occasionally use it in combination with B6 (if tolerated) for those with especially high pyrroles.Methionine and/or SAMeBoth are used, though usually not together, to help address undermethylation. I suspect candida or mold when someone is having difficulties tolerating either of these. These nutrients are usually better tolerated once candida and/or mold are addressed (or are starting to get addressed).5. Die-OffAnything that kills off microbes, such as candida or mold, can cause a “die off” of those microbes, release toxins, and worsen symptoms. Antifungal supplements, antifungal medication, and probiotics may cause this type of reactivity. Antifungal medications include nystatin, diflucan, itraconazole, and amphotericin B.Herbs and food-based supplements can have antimicrobial effects. Turmeric is one example. There are many others, so it's always worth checking. Worsening symptoms might point to an underlying fungal or other microbial overgrowth. It may also suggest that appropriate binders may be needed first.Addressing or preventing die-offs could mean supporting detoxification, starting binders if necessary, and, again, starting low and going slow.Antidepressants, interestingly, have been shown in labs to have antifungal effects. This does make me wonder if some people who can't tolerate them are having die-off.Root CausesKnowing someone's history of reactions can help point to underlying root causes.As you can see, there are typically ways to help someone tolerate and go on to benefit from a needed supplement or medication.As always, I welcome your thoughts and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Methionine is one of the most critical essential amino acids, involved in detoxification, DNA protection, and neurotransmitter production. But here's where it gets interesting—too much methionine has been linked to aging and disease, while too little can impair recovery, methylation, and cognitive function.In this fifth episode of our Essential Amino Acids Series, we explore:✅ How methionine supports liver detoxification and antioxidant production✅ The role of methionine in DNA protection, gene regulation, and cognitive function✅ Why methionine restriction is being studied for lifespan extension✅ Best food sources of methionine per 100g serving✅ The surprising connection between methionine and mental health

Discuss my thoughts on whether Dimethylglycine or Trimethylglycine is "better" for Homocysteine conversion to Methionine.This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources: https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/https://cen.acs.org/articles/82/i3/METHYLMERCURY-TOXICOLOGY-PROBED.html#:~:text=%22Glutathione%20can%20be%20pumped%20out,brain%20as%20methylmercury%2Dglutathione.%22https://pmc.ncbi.nlm.nih.gov/articles/PMC4540061/https://www.sciencedirect.com/science/article/pii/S0163725821001182https://www.sciencedirect.com/science/article/pii/S0163725821001182 Image Resource:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635095/ https://www.researchgate.net/figure/Overview-of-de-novo-glutathione-synthesis-Reduced-glutathione-or-GSH-is-a-tripeptide_fig2_5690064 https://lpi.oregonstate.edu/book/export/html/71 https://www.nature.com/articles/hr2011133 https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/methylenetetrahydrofolate-reductasehttps://chemtymology.co.uk/2020/11/27/cysteine-and-cystine/ https://fda.report/DailyMed/972f09a7-2aa1-4b1b-a6dc-2c4578a07803 https://www.thoughtco.com/definition-of-precipitate-604612 https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-p-benzoquinone-imine#section=3D-Conformer https://www.semanticscholar.org/paper/DRUG-METABOLISM-IN-THE-LIVER-Nguyen/4a29c6c4d433685a94b94602c012b8731cba5493https://pubchem.ncbi.nlm.nih.gov/compound/S-_Methylmercury_-L-Cysteine#section=2D-Structurehttps://keymerhealth.com/articles/seafood-mercury/https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://www.sciencedirect.com/science/article/abs/pii/S0304416519300133https://www.jbc.org/cms/10.1074/jbc.M111.265348/asset/822df563-eda2-4f48-a333-d01370a79e9c/main.assets/gr5_lrg.jpghttps://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065https://www.acs.org/molecule-of-the-week/archive/c/l-cysteine.htmlhttps://biologydictionary.net/glutamic-acid/https://www.researchgate.net/figure/An-overview-of-the-reaction-catalyzed-by-SHMT-and-its-context-in-the-folate-cycle-A-The_fig1_338995871https://pubchem.ncbi.nlm.nih.gov/compound/5-Methyltetrahydrofolate#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrofolic-acid#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/135398652#section=2D-Structure

In this solo episode of the Dr. Geo Prostate Podcast, Dr. Geo takes a deep dive into the long-debated question: Should you eat eggs? With rising egg prices sparking conversations, he explores the scientific evidence, nutritional benefits, and potential risks of egg consumption, especially in relation to prostate cancer and longevity.Dr. Geo shares insights from his years of research and clinical experience, debunking myths and providing practical takeaways on how to approach egg consumption for optimal health.Episode HighlightsAre eggs bad for prostate cancer? What the research really says.Methionine and choline – Two essential nutrients in eggs linked to both benefits and risks.How many eggs should you eat? The recommended safe intake.Egg types matter – Differences between caged, free-roaming, and pasture-raised eggs.Do eggs really raise cholesterol? The truth about dietary cholesterol and heart health.Protein and longevity – The role of eggs in maintaining muscle and metabolic health.The “Effort Day” approach – How to enjoy eggs without overconsumption.Nutrition research challenges – Why diet science is complex and often conflicting.Key TakeawayThere's no one-size-fits-all answer, but moderation is key. If you eat eggs, choosing pasture-raised eggs and limiting intake to two or three per week may be the best approach.If you found this episode valuable, don't forget to subscribe and leave a five-star review on Spotify and Apple Podcasts. Share it with friends, family, or anyone looking to take charge of their prostate health.Join Dr. Geo each week for expert insights, science-backed advice, and empowering conversations designed to help you live better with age. ----------------Thank you to our partnersThe ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that maintain the body in a fasting state.Special Offer: Thank you for listening, you can purchase the ProLon kit for just $148 by using this link.We'd also like to thank our partner AG1 by Athletic Greens. AG1 contains 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This special blend of ingredients supports your gut health, nervous system, immune system, energy, recovery, focus, and aging. All the essentials in one scoop. Enjoy AG1 by Athletic Greens.----------------Thanks for listening to this week's episode. Subscribe to The Dr. Geo YouTube Channel to get more content like this and learn how you can live better with age.You can also listen to this episode and future episodes of the Dr. Geo Podcast by clicking HERE.----------------Follow Dr. Geo on social media. Facebook,

In this episode of The Dairy Podcast Show, Chad Robbins, from Adisseo, discusses three essential topics for dairy producers: forage quality, the role of amino acids, and transition cow health. Drawing from his extensive industry experience, Chad offers practical advice on improving forage management, leveraging amino acid balancing for better milk production, and supporting cows during the transition period to maximize herd performance. Tune in now on your favorite platform!"Amino acid balancing is more than just a milk protein boost—it's about optimizing the overall health of the rumen."Meet the guest: Chad Robbins holds a Bachelor of Science in Biology from Huntington College and a Master's in Animal Science from the University of Tennessee-Knoxville. With over two decades of experience, Chad specializes in ruminant nutrition and currently serves as a Technical Sales Manager at Adisseo. His career spans roles in dairy consulting and feed management, equipping him with expertise in optimizing dairy cattle performance. What you'll learn:(00:00) Highlight(01:40) Introduction(05:05) Amino acid balancing(09:42) Forage quality(13:52) Milk Pay tool(18:14) Transition cow strategies(21:13) Methionine & reproduction(24:01) Final questionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo- Acepsis- Berg + Schmidt- Trouw Nutrition- Natural Biologics- Scoular- Priority IAC- dsm-firmenich- Diamond V- Protekta- Volac- SmaXtec- ICC

In this episode of The Pet Food Science Podcast Show, Dr. Michelina Crosbie from the University of Guelph shares her research on amino acid bioavailability in pet food. She talks about her innovative work on methionine in peas and chicken meals, shedding light on how this important amino acid influences metabolic processes in dogs. Dr. Crosbie also covers the challenges of using extruded diets and gives us a glimpse into the future of nutritional research for companion animals. Don't miss out on this fascinating conversation, available on all major platforms!"Bioavailability takes digestibility a step further, allowing us to quantify how much of an amino acid can actually be used in metabolic processes like protein synthesis."Meet the guest: Dr. Michelina Crosbie is a Research Assistant in Equine Physiology at the University of Guelph, with expertise in animal nutrition and educational development. She holds a Ph.D. in Canine Nutrition and an M.Sc. in Swine Nutrition from the University of Guelph. In her role, she contributes to research on amino acid bioavailability in pet food ingredients and provides mentorship to graduate students.What will you learn:(00:00) Highlight(01:15) Introduction(04:15) Amino acid bioavailability(07:15) Methionine & protein synthesis(17:15) Extruded diets(20:15) Bioavailability in pet food(23:15) Future of bioavailability research(25:17) Final QuestionsThe Pet Food Science Podcast Show is trusted and supported by innovative companies like:* Trouw Nutrition* Kemin- EW Nutrition- Alura- Symrise- Biorigin- ICC- Scoular- Corbion- ProAmpac

Send us a textTransform your understanding of amino acids with insights from Dr. Joel Bryn, a leading expert in biochemistry, physiology, and immunology. Discover the surprising impact that dietary choices on amino acids like methionine and glycine can have on longevity. Dr. Bryn shares groundbreaking research from the Orentreich Foundation, suggesting that a reduction in methionine intake and an increase in glycine might hold the key to a longer life. Prepare to challenge your preconceptions about what makes an amino acid "essential" as we uncover the significant health benefits of glycine.The episode takes a closer look at the often misunderstood term "non-essential" in the context of amino acids. Learn how glycine, despite being classified as non-essential, plays a vital role in managing inflammation and preventing chronic diseases like cancer, autism, and cardiovascular issues. Through Dr. Bryn's analysis, we explore how glycine deficiency impacts our health, particularly in younger generations, shedding light on modern health challenges. With analogies that simplify complex processes, this discussion reveals why rethinking our protein sources could be crucial for our well-being.The conversation with Dr. Bryn also navigates the historical and modern dietary landscape, emphasizing the importance of collagen-rich animal products to boost glycine intake. These age-old dietary habits might just be the key to combating the chronic inflammation pervasive in today's society. As we close out the episode, we reflect on how a balanced approach, centering on evidence-based nutrition, can lead to improved health outcomes. Tune in for a compelling narrative that intertwines scientific rigor with practical dietary advice, promising to reshape your view on nutrition and longevity.Support the show

This Real Science Exchange episode was recorded during a webinar, which was part of a series. Watch all the presentations from this series here: https://balchem.com/animal-nutrition-health/resources-categories/real-science-lecture-series/previous-lectures/page/10/Early in lactation, the cow is incapable of eating enough to meet her dramatically increased requirements. As the cow's intake decreases near calving, there are fewer nutrient contributions from dry matter intake and she must alter nutrient partitioning to meet her increased needs by mobilizing fat and muscle stores. (1:18)Triglycerides from fat stores are broken down into non-esterified fatty acids (NEFA) and glycerol. NEFA has two different fates in the postpartum cow: to the mammary gland as a precursor for milk fat synthesis, or to the liver to be oxidized for energy production. Glycerol enters the gluconeogenic pathway in the liver as a glucose precursor. (4:41)The capacity for the liver to use NEFA for energy is limited by the capacity of the TCA cycle. When the TCA cycle is at capacity, excess NEFA can either undergo incomplete oxidation to ketones or be repackaged back into triglycerides. If the capacity for other tissues to use ketones for energy is exceeded, then blood concentrations of ketones rise and negative outcomes from subclinical and clinical ketosis can occur. If triglycerides accumulate in the liver, negative outcomes associated with fatty liver can occur. Triglycerides can be transported out of the liver via very low-density lipoprotein (VLDL) export; however, VLDL export does not keep up with triglyceride concentration during the transition period in dairy cows, largely because of a limiting amount of phosphatidylcholine. (5:51)Dr. White describes a series of experiments in her lab using liver cells in culture to investigate the relationship between choline supplementation and VLDL export. As choline supplementation to the cell culture increased, so did VLDL export from the cells into the media. In addition, increasing choline supplementation to the cell culture also decreased cellular triglyceride content. (10:54)Using gene expression and radiolabeled tracers over a series of experiments, Dr. White's group found that as choline supplementation increased, so did complete oxidation of NEFA to energy. This was accompanied by decreased incomplete oxidation to ketone bodies and decreased accumulation of lipids in the liver cells. Glucose and glycogen were also increased with increasing choline supplementation to the cell culture, and a decrease in reactive oxygen species was observed. In addition, choline-supplemented cultures exhibited an increase in metabolic pathways associated with methionine regeneration and methyl donation. (15:29)Dr. White then details the complexity of the metabolic pathways that intersect between choline and methionine. In similar experiments supplementing cell cultures with increasing amounts of methionine and choline, there were no effects of methionine on lipid export, oxidative pathways, or glucose metabolism. The main benefit of methionine was a marked increase in glutathione production. It's important to note that no interactions between choline and methionine were observed in this series of experiments. (19:37)There seems to be a clear biological priority for different sets of pathways for choline and methionine. Choline seems to be influencing lipid, glucose, and oxidative pathways, while methionine is primarily serving its role as an essential amino acid for cellular protein structure and generation, acting as a methyl donor, and impacting inflammation. Importantly, both the choline and methionine results observed in cell culture are paralleled in transition dairy cow studies. (24:14)Dr. White's lab further investigated the impact of methionine on inflammation. When cells were challenged with LPS to provoke an inflammatory response, methionine mitigated the inflammatory response. Similar results have been observed in liver tissue samples of transition cows. Methionine mitigated inflammatory markers and increased glutathione but did not influence reactive oxygen species. Conversely, choline decreased reactive oxygen species but did not change glutathione. (27:47)Choline and methionine are both essential nutrients, there are biological priorities for them as methyl donors, and they are not mutually exchangeable. The lack of interaction between choline and methionine in vivo or in vitro supports the idea of different biological roles for these nutrients. (32:09)Dr. White takes questions from the webinar audience. (34:53)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Hello there!In this episode of The Dairy Podcast Show, Dr. Kraig Peel, from Adisseo, explores the role of amino acid balancing—especially methionine—in enhancing reproductive health and boosting production efficiency in dairy cows. Dr. Peel breaks down how optimizing methionine levels can significantly impact fertility and overall herd performance, offering practical strategies to improve herd health and productivity. Listen now!"We see immediate results in dairy cattle when we add protected methionine to their diets, which can impact milk protein production right away."Meet the guest: Dr. Kraig Peel, currently a Technical Support Specialist at Adisseo, holds a master's and Ph.D. in animal science from Texas A&M University. With expertise in animal nutrition, reproduction, health, and welfare—especially in cattle—Dr. Peel's extensive background spans academic roles and field consulting, where he advises on scientific applications for dairy cattle health and production.What you'll learn:(00:00) Highlight(00:38) Introduction(01:05) Professional background(06:52) Bypass amino acids(09:40) Methionine's role(11:37) Reproductive health(13:33) Consulting challenges(19:11) Final three questionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo- SmaXtec- Acepsis- Trouw Nutrition- Protekta- Natural Biologics- dsm-firmenich- ICC- Berg + Schmidt- Diamond V- Volac

Hello there!In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Lucas Rebelo discusses the impact of methionine on milk fat production. Dr. Rebelo elaborates on how methionine upregulates enzymes that promote fatty acid synthesis, particularly in Holstein cows. He also touches on the challenges and future research directions in this area. Tune in to explore cutting-edge insights into optimizing milk fat content through amino acid supplementation."Amino acids like methionine exert an effect on milk fat through the upregulation of transcription factors or enzymes associated with de novo fatty acid synthesis."Meet the guest: Dr. Lucas Rocha Rebelo is a Dairy Technical Manager at Adisseo with a strong background in dairy nutrition and environmental science. He earned his Ph.D. from The Ohio State University, where he researched amino acid metabolism in dairy cows. Dr. Rebelo also holds an M.Sc. in Ruminant Nutrition from Universidade Estadual Paulista and a B.Sc. in Animal Science from the Federal University of Mato Grosso.What will you learn: (00:00) Highlight(01:10) Introduction(01:56) Methionine's effect on milk fat(02:54) Supplementation rates and responses(04:16) Mode of action of methionine(06:41) Dietary interactions with methionine(08:10) Research on other amino acids(09:51) Closing thoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Virtus Nutrition- Evonik- Volac

This episode comes to you from the 2024 Tri-State Dairy Nutrition Conference, where Balchem sponsored a Real Science symposium titled “New Discussions in Amino Acid Nutrition.” Each of our guests presented at the symposium, and their presentations can be found at balchem.com/realsciencemediaDr. Van Amburgh presented “Amino Acid Nutrition for Maximizing Milk Component Yield.” When considering nitrogen efficiency, we generally compare intake nitrogen, which includes non-protein nitrogen, against milk nitrogen. In high producing cows, aggregate amino acid values are running about 70 to 73% efficiency. But when we work that up to total intake nitrogen, then we're down to 30 to 35% efficiency range. How do we reconcile ruminal nitrogen requirements to a point where we can optimize the capture of recycled nitrogen and reduce the amount of nitrogen that's being excreted in the urine? (2:27)Dr. Hanigan presented “Understanding Amino Acid Bioavailability.” Our current methods for measuring bioavailability don't all have the same precision. One of the classic methods, intestinal disappearance, has very low precision. Methods that rely on dilution of a marker or a label in blood or milk have much higher precision. Dr. Hanigan's lab has worked to modify a carbon-13 labeled amino acid method to allow for evaluating changes in the supply of amino acids in the diet.  (5:01)Dr. Lee presented “Current Understandings of Lysine Nutrition in Dairy Cattle.” Rumen-protected lysine has more variable responses than rumen-protected methionine or histidine. Amino acid requirements were developed based on the role of amino acids as the building blocks of protein. But there are many roles of amino acids which may influence their requirements. Dr. Lee suggests including that type of information in our modeling may increase the consistency of responses to feeding rumen-protected lysine. (11:24)Dr. Hristov presented “Histidine: A Limiting Amino Acid for Dairy Cows.” His group has worked with rumen-protected histidine to develop a dataset to define requirements. Microbial protein has considerably less histidine than methionine yet they are secreted at about the same level in milk and are metabolized similarly. All this together points to a higher histidine requirement. (18:02)The panelists agree that the advent of genomics have resulted in a rapid change in high producing cows and with that, their amino acid requirements (and other nutrients) are also changing. It's a challenge for feeding and nutrition programs to keep up with rapid genetic change. (21:02)A question was posed by the audience about how Dr. Van Amburgh used amino acids to increase butter fat. In the research he presented, the diets did not overfeed fat and fed a blend of fatty acids, and also increased the sugar and pulled back the starch. (28:35)A discussion of histidine follows, including its unique body reserves, its role in hemoglobin concentrations, and its potential impacts on metabolic energy efficiency (34:08)Dr. Zimmerman asks about plasma histidine in very early lactation cows. Dr. Hristov is currently conducting a fresh cow experiment to assess this. His hypothesis is that because of low dry matter intake and high metabolic demand for amino acids, there will be a response to histidine supplementation. Dr. Lee agrees and feels that the fresh cow stage may be one of the most practical ways we can utilize rumen-protected histidine (39:39)A question from the audience about the use of blood meal in lower protein diets sparks a spirited discussion among the panelists. (41:55)In closing, each panelist provides a takeaway. Responses range from bioavailability of rumen-protected products to challenges to progress for ruminant amino acid research to comparing biological potential and economic response. (46:58)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Danielle Sherlock explores the interactions between heat stress, rumen-protected methionine, and immune function in dairy cattle. She discussed how supplementation can mitigate the negative impacts of heat stress on immune function and overall metabolism. Tune in on major platforms to discover how these findings can transform dairy cattle management."Methionine supplementation helps to overcome negative effects of the transition period on immune function and oxidative stress."Meet the guest: Dr. Danielle Sherlock is the Ruminant Research and Innovation Science Manager at Adisseo. She has a rich academic background from Ohio State University and the University of Illinois. Her Ph.D. research concentrated on the metabolism of methyl donors, particularly under conditions of heat stress and negative energy balance in dairy cows. Dr. Sherlock's work offers valuable insights into nutritional strategies that enhance dairy cow health and productivity during stress periods.What will you learn: (00:00) Highlight(00:55) Introduction(02:19) Heat stress and immune cell activation(03:35) Effects of heat stress on metabolism(04:45) Insulin sensitivity under heat stress(06:31) Heat stress and immune function(07:19) Discussing methionine supplementation(08:19) Closing thoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Volac

Amino acid balancing plays a crucial role in enhancing feed efficiency, promoting cow health, and increasing milk production in the dairy cattle industry. Join Franck Gaudin as he delves into the latest trends and insights, uncovering the keys to improving dairy production and maintaining optimal health in cows."Amino acid balancing is crucial in dairy nutrition, leading to better milk quality and cow health."Meet the guest: Franck Gaudin, Dairy Business Director at Big Gain Feed Inc., brings extensive expertise to the dairy industry. Based in Lakeville, Minnesota, he plays a pivotal role at Big Gain, an esteemed agriculture company founded in 1973. With a dedicated team, Franck leads with innovation and a deep understanding of dairy business dynamics.What you'll learn:(00:00) Highlight(00:56) Introduction(01:59) Results and benefits of amino acid balancing(02:37) Link between milk protein and cow health(03:32) Methionine's role in dairy production(03:47) Broader influence of amino acids(04:30) Future potential in amino acid balancing(05:52) Closing thoughts and conclusionThis Dairy Podcast Show Episode is trusted and supported by:* AdisseoAre you ready to unleash the podcasting potential of your company? wisenetix.co/custom-podcast

In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Phil Cardoso, an Associate Professor from the University of Illinois, explores the innovative approaches in dairy nutrition, focusing on integrating nutrition and reproduction. Dr. Cardoso approaches the pivotal role of Rumen-protected methionine in enhancing transition cows' health, examining its impact on protein synthesis, milk protein, and reproductive performance. Insightful discussions extend to its effects on calves' immune responses and placenta changes, underscoring the nuanced relationship between nutrition and dairy cow well-being. Tune into this episode on all major platforms to understand how strategic nutrition management can significantly influence dairy production outcomes.“We super-ovulated those cows, we harvested the embryos, and we saw some differences there.” - Dr. Phil CardosoMeet the guest: Dr. Phil Cardoso, an Associate Professor at the University of Illinois since 2012, specializes in the intersection of dairy nutrition and reproduction. His work, pivotal in understanding the nutritional nuances that influence dairy cow and calf health, provides invaluable insights into improving dairy production through strategic nutrition management. What will you learn: (00:00) Highlight(00:38) Introduction(01:02) Role of Rumen-Protected Methionine(01:53) Impact on Reproduction and Embryo Growth(04:00) Supplementation Protocol(06:06) Nutritional Strategies and Protein Synthesis(08:20) Colostrum Quality and Amino Acid Impact(08:28) Closing ThoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Volac

In this episode of The Dairy Nutrition Blackbelt Podcast, we welcome Dr. Danielle Sherlock, a Ruminant Science Manager at Adisseo and a distinguished researcher with extensive experience in dairy cow metabolism under stress conditions. Dr. Sherlock discusses the benefits of rumen-protected methionine during heat stress in dairy cows, based on recent research findings. This conversation is vital for anyone in the dairy industry seeking to understand and mitigate the impacts of heat stress on cow metabolism and milk production. Tune in on major platforms to explore innovative strategies for enhancing dairy cow health and productivity.“We knew in transition cows that methionine has a lot of effects beyond just being used for protein synthesis and production.” - Dr. Danielle SherlockMeet the guest: Dr. Danielle Sherlock is the Ruminant Science Manager at Adisseo, with a rich academic background from Ohio State University and the University of Illinois. Her Ph.D. research concentrated on the metabolism of methyl donors, particularly under conditions of heat stress and negative energy balance in dairy cows. Dr. Sherlock's work offers valuable insights into nutritional strategies that enhance dairy cow health and productivity during stress periods.What will you learn: (00:00) Highlight(00:36) Introduction with Dr. Bill Weiss(01:10) Overview of Dairy Cow Metabolism Research(04:15) Heat Stress Effects on Cows(05:17) Behavioral Changes in Heat-Stressed Cows(06:45) Milk Composition and Methionine(07:52) Supplementation Strategies for Heat Stress(08:45) Closing ThoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Volac

In this week's episode we'll report on the findings from a study evaluating the long-term outcomes of pulmonary embolism in children and adolescents, discuss a new mechanism for hereditary angioedema caused by a methionine-379 to lysine substitution in kininogens, and learn more about predictors of unsustained minimal residual disease negativity in multiple myeloma patients.

Today, we will be learning why our muscular skeletal system may be out most important organ we have and how a Muscle-Centric Nutrition approach contributes to our to health and longevity and can preventing obesity, and other health issues such as cancer. We'll be looking at the essential roles that protein and amino acids play, optimal dietary protein needs, ideal timing of protein intake, best sources, and everything we need to know about protein synthesis.  My guest is Don Layman, Professor of Food Science and Human Nutrition at one of the top agriculture colleges in the world, the University of Illinois Urbana-Champaign College of Agricultural.   Don earned his B.S. in Chemistry and M.S. in Biochemistry at Illinois State University and his Ph.D. in Human  Nutrition and Biochemistry at the University of Minnesota, St. Paul.   His research focuses on understanding the protein and amino acid requirements and interrelationship between dietary protein and carbohydrates needed for adult health.   In particular, his research seeks to understand the impact of diet and exercise on obesity, type 2 diabetes, and metabolic syndrome in adults.  His work has helped to define the role of branched chain amino acids (BCAA) in skeletal muscle metabolism.   BCAA provide an important energy source for muscle during exercise and also serve as a critical regulator of muscle protein synthesis during recovery.  During exercise, oxidation of BCAA increases, resulting in production of the amino acid alanine and a rapid decline in plasma levels of BCAA.  Amino acid supplements prevent this decline in plasma amino acids, enhance recovery of muscle protein synthesis and interact with insulin to help stabilize blood glucose.  His research continues to define mechanisms for control of muscle protein synthesis and differences in dietary protein needs for men versus women and for adults with sedentary versus active lifestyles.  He's dedicated over 40 years investigating the intricate role of dietary protein in muscle protein synthesis and the impact of diet and exercise on obesity, type 2 diabetes, and metabolic syndrome in adults.  His research has significantly contributed to our understanding of the interplay between nutrition, muscle health, and overall well- being.  Well Learn: The Basics of Protein and Amino Acids and their role in Nutrition Why Leucine, Lysine, and Methionine are Essential Amino Acids and foods we get them from Key things we need to know about protein synthesis Recommended Dietary Allowance (RDA) for Protein, how it was calculated and why it's not optimal The optimal amount of protein we need based on Don nLayman research How the size and frequency of meals impacts muscle protein synthesis Small meals versus big meals? Specifics around protein intake that should be followed with time restricted eating. How to track their protein intake effectively How to determine the quality of protein sources, what are our best sources And how factors like absorption rates play a role in protein source selection Don Laymans thoughts on plant-based and synthetic "meats" in the market from a nutritional standpoint High Protein Diets for Fat Loss - Results from Clinical Trials Consequences of Protein Deficiency in Childhood, how it impacts long term health Optimal protein intake amounts for a child Saturated fat and our health Muscle-Centric Nutrition Philosophy The significance of our muscular skeletal system to health, longevity, preventing obesity, and other health issues such as cancer Role of Muscle in Glucose Storage and Insulin Resistance The connection between muscle health, insulin resistance, and the development of diabetes    **To donate/tip our channel, below through our Paypal. Paypal Donation Link: https://www.paypal.com/donate/?hosted_button_id=6YECDNX33L4KQ   DTH Mailing List: https://mailchi.mp/a285090e8123/discovering-true-health-mailing-list Frequency Healing Device: https://us.healy.shop/?partnername=5058-6574-1579   Links for Don Layman Ph.D. Web sight: metabolictransformation.com Bio and Research: https://fshn.illinois.edu/directory/dlayman Twitter: @donlayman   Stay In Touch with Us! Instagram:   @DiscoveringTrueHealth Twitter:        @DTrueHealth  Facebook:   @discoveringtruhealth Rumble:       Discoveringtruehealth   Listen On:  Apple Podcast Spotify   Watch On: YouTube   www.discoveringtruehealth.com     Medical disclaimer: Discovering True Health LLC does not provide medical advice. Discovering True Health and the content available on Discovering True Health's properties (discoveringtruehealth.com, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.          

Dr. Räisänen completed this research during her Ph.D. at Penn State. The meta-analysis included 17 different studies published between 1999 and 2022 investigating supplemental histidine for lactating dairy cows. They divided the type of supplemental histidine between infused histidine and rumen-protected histidine and the basal diets between corn silage-based and grass silage-based. (4:34)Primary response variables measured in the meta-analysis included dry matter intake, milk production, milk composition, and milk component yields. The researchers also calculated the efficiency of utilization of histidine and other amino acids supplied to the cow by the diets. Lastly, they calculated marginal recovery of histidine and evaluated the interaction between histidine supply and energy supply and how that impacts the efficiency of utilization. (7:38)Dr. Lapierre gives a little history of histidine research. When recommendations were coming out about lysine and methionine requirements, the different studies recommended relatively similar amounts of lysine and methionine based on the proportion relative to MP supply. On the other hand, recommendations for histidine varied widely depending on the study, ranging from less than 2% to almost 4%. As emphasis has been placed on reducing the footprint of dairy production, interest has risen in feeding lower-protein diets. In this scenario, we would expect an increase in the microbial protein; however, microbes are relatively low in histidine content. If we look at the proportion of histidine relative to MP, as the crude protein concentration of a diet decreases, this proportion of histidine decreases. (8:34)The meta-analysis revealed a clear response to histidine in milk production, dry matter intake, and milk true protein yield. Susanna and Helene are not sure if the dry matter intake response was due to a pulling effect because of increased milk and milk protein yield or if histidine has an independent impact on the brain, as has been observed in some monogastric studies (16:15)Clay asks the guests what they think the histidine requirement is, and both agree that providing one number is not practical given the other interactions from basal diet to the efficiency of utilization to the concentration of other amino acids in the diet. (32:01)Practical implications from the meta-analysis include an understanding that lower protein diets may very well need supplemental histidine for optimum performance, and cows pay a penalty when inadequate histidine is supplied. (35:09)Helene's take-home message is that histidine should be taken seriously. If you don't supply enough of it, then you'll have a penalty in your cows' production. Further, the efficiency of histidine utilization will be affected by the energy supply, and we have tools with NASEM to assess if a herd is receiving sufficient histidine. Susanna echoes Helene's message and adds that a rumen-protected histidine product on the market would be very helpful. (45:35)The paper can be found here: https://www.journalofdairyscience.org/article/S0022-0302(23)00416-2/fulltextPlease subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

On this episode, co-hosts Dr. Tania Cubitt and Katy Starr discuss the topline of horses including:The most common reasons for a poor topline in horsesTips to improve a horse's topline with nutritionSpecific nutrients that impact a horse's toplinePoor topline in horses is a common concern among horse owners, so this topic will be sure to provoke considerable interest! Send this to someone you think would benefit from this episode.Have a topic idea or feedback to share? We want to connect with you! Email podcast@standlee.com____________________________________ Additional Resources or References during this episode – 3:30 – Body Condition Scoring System3:56 – Cresty Neck Scoring System“Cresty Neck – A Precursor to Metabolic Disease in Horses” blog post - https://www.standleeforage.com/standlee-barn-bulletin/cresty-neck-a-precursor-to-metabolic-disease-in-horses/“Ep. 057: How to Prevent and Manage Laminitis” podcast episode - https://www.standleeforage.com/podcast/episodes/ep-057-how-to-prevent-and-manage-laminitis/“Ep. 052: Why Your Horse is Overweight, and You Probably Don't Know It” podcast episode - https://www.standleeforage.com/podcast/episodes/ep-052-why-your-horse-is-overweight-and-you-probably-dont-know-it/4:24 – Development of an equine muscle condition score (initial research on muscle conditioning in 25 thoroughbred horses) - https://beva.onlinelibrary.wiley.com/doi/full/10.1111/eve.1377712:58 – Refeeding Syndrome and how to safely feed a neglected, starving rescue horse – chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://ceh.vetmed.ucdavis.edu/sites/g/files/dgvnsk4536/files/local_resources/pdfs/pubs-July2012-bkm-sec.pdf“How Can I Safely Feed a Neglected/Starved Horse Back to Health?” webinar - https://www.standleeforage.com/nutrition/nutritional-webinars/safely-feed-a-neglected-horse-back-to-health/32:15 – “Myth or Fact? Horses Can't Digest Oils” podcast episode - https://www.standleeforage.com/podcast/episodes/ep-0012-myth-or-fact-horses-cant-digest-oils/____________________________________Love the podcast? Leave a rating and review on Apple – https://podcasts.apple.com/.../beyond-the-barn/id1541221306Leave a rating on Spotify – https://open.spotify.com/show/3dmftQmwLKDQNueUcCJBZaHave a topic idea or feedback to share? We want to connect with you! Email podcast@standlee.comShare our podcast and learn more about our co-hosts at our Beyond the Barn podcast pageSUBSCRIBE to the Beyond the Barn podcast email to be an exclusive insider!Find us on Apple, Spotify or Google Podcasts and SUBSCRIBE, so you never miss an episode.____________________________________Check out the Standlee Barn Bulletin BlogFind more nutritional resources from Dr. Stephen Duren and Dr. Tania Cubitt at https://www.standleeforage.com/nutrition/nutritional-resources/Connect with Standlee on Facebook, Instagram, YouTube and TikTok____________________________________*Views and opinions expressed by guests are their own and do not necessarily reflect the view of Standlee Premium Products, LLC.*

The MTHFR gene error can lead to a host of deficiencies that ripple through your health, impacting everything from your liver to your mood. A deficiency in the essential amino acid Methionine, for example, can manifest in elevated cholesterol, liver issues, and even dementia. This deficiency is closely linked with low levels of SAM-e, a crucial molecule in the body, and can inhibit the recycling of Glutathione, the body's master antioxidant. Further complicating the picture are the roles of various B vitamins like B12, B9 (Folate), B6, and B2. An MTHFR gene error can disrupt these vital nutrients, leading to extreme fatigue, mood changes, and a cascade of other symptoms, including anemia and neuropathy. The gene error also affects the production of other important molecules and amino acids like L-Serine, which is critical for central nervous system function and Glutathione production. All told, the MTHFR gene error can have a far-reaching impact on your overall health.

Timestamps: 01:40 Glycine and Methionine for Longevity 10:45 Risks of High Homocysteine 15:10 Why You Need Glycine 19:45 How Bad Is High Homocysteine 22:45 Optimal Protein Ratios 26:35 How Much Glycine to Take 31:57 Can Taurine Extend Lifespan 38:15 Finding Your Genetic Bottlenecks 44:08 Power of Genetics 45:26 Is MTHFR Important 55:18 How to Find Your Genetic Bottlenecks 01:00:15 Whole Genome Sequencing 01:06:35 How Important Are Your Bottlenecks 01:09:11 How to Get Your Whle Genome Sequenced 01:11:40 What to Focus on For Longevity Chris Masterjohn YouTube channel: https://www.youtube.com/@chrismasterjohn Use code SIIM https://donotage.org/ref/Siim%20Land/ to get an extra 10% discount

A new research paper was published in Aging (Aging-US) Volume 15, Issue 11, entitled, “Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice.” Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. In this new study, researchers Yutaro Kubota, Qinghong Han, Jose Reynoso, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Michael Bouvet, Takuya Tsunoda, and Robert M. Hoffman from AntiCancer Inc., University of California San Diego and Showa University School of Medicine observed C57BL/6 mice double their body weight from 4 to 48 weeks of age and become obese. The team then evaluated the efficacy of oral administration of recombinant-methioninase (rMETase)-producing E. coli (E. coli JM109-rMETase) or a methionine-deficient diet to reverse old-age-induced obesity in C57BL/6 mice. “In the present study we tested a low-methionine diet to reverse old-age-induced obesity. [...] E. coli JM109-rMETase was also tested in the present study to reverse old-age-induced obesity.” Fifteen C57BL/6 male mice aged 12–18 months with old-age-induced obesity were divided into three groups. Group 1 was given a normal diet supplemented with non-recombinant E. coli JM109 cells orally by gavage twice daily; Group 2 was given a normal diet supplemented with recombinant E. coli JM109-rMETase cells by gavage twice daily; and Group 3 was given a methionine-deficient diet without treatment. The administration of E. coli JM109-rMETase or a methionine-deficient diet reduced the blood methionine level and reversed old-age-induced obesity with significant weight loss by 14 days. There was a negative correlation between methionine levels and negative body weight change. Although the degree of efficacy was higher in the methionine-deficient diet group than in the E. coli JM109-rMETase group, the present findings suggested that oral administration of E. coli JM109-rMETase, as well as a methionine-deficient diet, are effective in reversing old-age-induced obesity. “In conclusion, the present study provides evidence that restricting methionine by either a low-methionine diet or E. coli JM109-rMETase has clinical potential to treat old-age-induced obesity.” DOI - https://doi.org/10.18632/aging.204783 Corresponding author - Robert M. Hoffman - all@anticancer.com Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204783 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, obesity, methionine restriction, methionine-deficient diet, recombinant methioninase (rMETase), Escherichia coli, microbiome, weight-loss About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

We are excited to bring to you our brand new podcast, the Pet Food Science Podcast! This is where we dive deep into the world of pet nutrition alongside the brightest minds in the global pet food industry – all of it available right in your pocket! In our very first episode, Dr. Julia Pezzalli shares her findings on the amino acid requirements for cats. She also emphasizes methionine and introduces the indicator amino acid oxidation (IAAO) method, which helps determine protein quality, assess amino acid requirements, and optimize protein intake for specific needs. Furthermore, we go into some changes there have been to pet nutrition over time, some interesting insights about the relationship between the owner and pet nutrition, and important specific fat acids for pets."We need to make efforts to address protein quality, including the ratio of amino acids, even though that can be a challenge with dogs and cats due to the use of varied processing techniques." - Dr. Julia Pezzali(00:00) Highlight(01:00) Introduction(02:24) Methionine requirements for cats and the IAAO technique(10:08) Protein quality and amino acid ratios for pets(12:22) Changes in pet nutrition over time(16:50) How diet influences gut microbes and indirectly affects digestion(20:18) The relationship between owners and the well-being of their pets(22:03) Specific fatty acids in pet nutrition(25:09) Final considerationsMeet the guest: Dr. Julia PezzaliExperience:Assistant Professor (Iowa State University)Background:Ph.D., Cat Nutrition and Metabolism (University of Guelph - Canada)M.Sc., Pet Food Processing and Dog Nutrition (Kansas State University - US)B.Sc., Veterinary Medicine (Federal University of Rio Grande do Sul - Brazil)Connect with the guest!

Dr. Amber Harris author of "d,l-Methionine in combination with amoxicillin–clavulanic acid successfully dissolves spontaneously occurring infection-induced struvite urocystoliths in dogs: a pilot study in: Journal of the American Veterinary Medical Association - Ahead of print (avma.org)" discusses how d,l-methionine and amoxicillin–clavulanic acid can be used without changing diet for dissolution of infection-induced struvite urocystoliths in dogs. Hosted by Associate Editor Dr. Sarah Wright and Editor-in-Chief Dr. Lisa Fortier.INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA OR AJVR?JAVMA: https://avma.org/JAVMAAuthorsAJVR: https://avma.org/AJVRAuthorsFOLLOW US:JAVMA:Facebook: Journal of the American Veterinary Medical Association - JAVMA | FacebookInstagram: JAVMA (@avma_javma) • Instagram photos and videosTwitter: JAVMA (@AVMAJAVMA) / Twitter AJVR: Facebook: American Journal of Veterinary Research - AJVR | FacebookInstagram: AJVR (@ajvroa) • Instagram photos and videosTwitter: AJVR (@AJVROA) / TwitterJAVMA and AJVR LinkedIn: https://linkedin.com/company/avma-journals#VeterinaryVertexPodcast #JAVMA #AJVRINTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

My guest this week has been ALL OVER the news cycle. A man who spends $2M on his body to age backwards!!!??? If you could age backwards, how would you do it? And not just your face (but that too) but each and EVERY organ in your body! What's the multi-millionaire version and what's the accessible version?  This week I'm talking to Oliver Zolman MD, he's the doctor of Bryan Johnson, a tech millionaire who, indeed, spends $2M a year on trying to age backwards. What's the science about aging and aging backwards? Is it possible and what's the latest? Oliver talks to me about the latest in dietary science (eating to stay young), the skin science (how to look young) and SO much more. He is a true wealth of knowledge! And checkout Magnesium Breakthrough by BiOptimizers for an exclusive offer at magbreakthrough.com/zaddy. In addition to the discount you get by using promo code zaddy, you can unlock special gifts with purchase with retail values of at least 20 dollars. Athletic Greens giving a FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase. All you have to do is visit athleticgreens.com/zaddy. You can find him at: IG YouTubeLinkedinhttps://www.oliverzolman.com/ Subscribe or keep tuning in at: IGTik toklukecook.comNewsletter INTRO 2:15Background, back problems, med school. His goal is disease modifying therapy for aging. 3:30His Client - Brian Johnson - who's spending millions of dollars to be an 18 year old again.The reversal of aging and how his approach differs. 5:30How young are Brian's organs?His heart rate variability is down 15yrs.Heart rate variability is…Why it's valid and valuable as a marker. How you can measure yours. 9:00Reducing stress & HRV rejuvenation causality.How they clinically measure.Caloric intake as it relates to longevity and HRV.Brian offsets his vegan diet with collagen peptides.How you can monitor your vitamins and minerals to increase longevity. 13:20Vegan or not to vegan - in the search for preservation.Core things to consume and avoid on his list, more on his website that we mention at the end.Caloric restriction with Omega 3, Omega 6, Trans Fats.ALA, DHA, EPA. 18:45Ways to get into a healthy caloric deficit. 21:00Fasting. Case study and its effects. Why it's less effective.Monkey Centenarians. 24:35Skincare: Millionaire Version & Cheap Version.Topical therapies.What skin is made up of and filling the fat gaps. 28:20Brian has donated his body to science.The least invasive, most effective lasers.IPL & BBL.Collagen Induction & Micro-needling. 31:43More on, collagen supplementation.Protein and AGF1 levels.Glycine to offset Methionine.  36:14More skincare.UV A&B wide wavelength filters.Sun exposure.Vit D.Lycopene.  40:50Ablative lasers.His tanning guidelines and dangerous tanning options.The lack of knowledge on the new tanning peptides and drugs. 47:30Recommendations for skin treatments that are less expensive.SculptraProfiloPRF 50:40TEETH! Keep ‘em young.Flossing, always flossing.Tea Tree Oil.Lithium water.Rates of suicide and correlatives with lithium natural spring water. 56:15The next ten years, what's in store for the future.Longevity School - it'll be available to everyone soon, it's currently for clinical study.See omnystudio.com/listener for privacy information.

Go to https://thld.co/zbiotics_siim_0123 and get 15% off your first order of ZBiotics Pre-Alcohol Probiotic by using my code SIIM at checkout. Thanks to ZBiotics for sponsoring today's video! Timestamps: 01:11 Thoughts on L-Theanine 02:27 Glycine vs Inositol for Sleep 03:30 Is Viagra Longevity Drug? 05:00 Thoughts on Finasteride 07:50 Glycine with Methionine or Alone 08:36 Carbs First Or Protein First 10:25 Do I Use Nicotine 11:25 How Much Magnesium Can Your Body Absorb 12:52 L-Theanine vs Tyrosine 14:00 How to Increase HRV 16:00 Best Non-Dairy Calcium Sources 16:43 Potatoes Fried in Olive Oil - Good or Bad 18:00 Vitamin C and Garlic Pre-Workout 20:00 Best Vegan Protein Sources 20:57 Thoughts on Bryan Johnson 23:01 Negative Effects of Too Many Antioxidants 28:14 Knee Pain Rehab Exercises Get the Biological Age Test Kit + Consultation: https://www.siimland.co/offers/FZVrSHei

Description: Dr. Maya Graham interviews Drs. Gaia Ninatti and Martina Sollini about their recent manuscript entitled: "Pre-operative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas", published online in Neuro-Oncology in September 2022. Full Report

In this week's episode, we'll learn more about the impact of dietary methionine restriction on the progression of AML, discuss transferrin upregulation as a cause of high-altitude-induced hypercoagulability, and learn more about the protective effects of leukemia inhibitory factor against graft-versus-host disease.

Dairy producers face a number of challenges in producing milk profitably, and an understanding of rumen function and ways nutritional strategies can unlock additional pounds of milkfat is one avenue for increasing the opportunity for profitability.At the World Dairy Expo in Madison, Wisconsin, earlier this month, Novus International debuted a new program called Scale Up™; the program is designed to turn production challenges into herd profitability by providing innovative feeding strategies that optimize milk and component yields. Along with increasing beneficial microbiota in the rumen and optimizing rumen function, the program aids in optimizing feed intake and meeting the metabolic needs of lactating cows.In this episode we talk with Ceclia Lopez, Novus' North America ruminant marketing manager, and Dr. Will Seymour, ruminant technical services manager, to learn more about Scale Up.This episode is sponsored by Novus International. You can learn more about the Scale Up program for Dairy by visiting NovusINT.com.

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/gabriellelyon  2:10 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:25 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:00 - AVALONX MAGNESIUM 8: Get Melanie's Broad Spectrum Complex Featuring 8 Forms Of Magnesium, To Support Stress, Muscle Recovery, Cardiovascular Health, GI Motility, Blood Sugar Control, Mood, Sleep, And More! Tested For Purity & Potency. No Toxic Fillers. Glass Bottle.  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Order At avalonx.us, And Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist, And Use The Code MelanieAvalon For 10% On Any Order At avalonx.us And mdlogichealth.com!  5:40 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:30 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At melanieavalon.com/cleanbeauty! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:20 - Gabrielle's Background 16:20 - The Effect Of Body Composition And Obesity On Brain Tissue 18:00 - Methionine Restriction  20:00 - Integrated Stress Response 21:20 - Vegan Diets And Health Outcomes 25:10 - Full Restriction Vs Cyclical Restriction  27:10 - The Importance Of Protein Quality 29:30 - Nitrogen Balance  31:00 - RDA 34:00 - The Ratio Of Protein Needed Per Lean Mass 35:40 - Basic Vs Optimal 38:10 - Leucine 40:25 - Protein Absorption And Digestion  41:15 - Multiple Meals Vs One Meal A Day  46:10 - Muscle Maintenance And Muscle Growth 47:30 - Gluconeogenesis 48:50 - Enzymatic Adaptation 49:45 - EMSCUPLT 52:30 - Consuming Excess Protein 53:10 - BUN Creatinine Ratio 54:50 - Filtration Rate 55:00 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack For Only The Price Of Shipping! 57:55 - Are You Burning Fat Or Muscle In A Protein Deficit?  1:00:00 - Protein Sparing Modified Fasts 1:00:30 - Myokines 1:04:40 - Growth Hormone And Fasting 1:05:50 - Protein Intake And Longevity  1:16:15 - Protein Scores On Food Labels 1:20:15 - Plant Based Nutrition

Background Information—Form and Function of B12 Vitamin B12 Form Cyanocobalamin has no known biochemical function. It must be converted to become active. It gets converted for use into hydroxocobalamin, methylcobalamin, or adenosylcobalamin. These three forms are equal in bioavailability.An exception to this is for the use of adenosylcobalamin in infants with a rare inborn error of synthesis.Methylcobalamin and adenosylcobalamin are coenzyme forms of B12.Hydroxocobalamin can be converted into the above two forms. Click here to learn more about the Hedberg Institute Membership. Vitamin B12 Function Vitamin B12 is used for DNA synthesis, homocysteine metabolism, S-adenosylmethionine, red blood cell formation, nervous system and immune system function.Vitamin B 12 is necessary for folate to be metabolized properly into Methionine and Succinyl-CoA. Low levels of B12 and increased levels of folate are associated with higher concentrations of methylmalonic acid (MMA) and total plasma homocysteine (HCY). Vitamin B12 Sources The average American diet contains adequate amounts of vitamins B12, ranging from 5-15 mcg/day. Meat, poultry, fish, eggs, and dairy, constitute the primary food sources. It is not found in most non-animal food sources. Individuals consuming a plant-based diet are at an increased risk of deficiency. Non-meat food sources such as chlorella, spirulina, nori, and fermented soy contain mostly B12 analogues which have no activity in humans. Fifty-one percent of those following a macrobiotic diet were found to be deficient.Vegan Diets 0.3-0.4 mcg/dayLacto-vegetarians 1.4 mcg/day Recommended Dietary Allowances (RDA)Males >14 years: 2.4 mcg/dayFemales >14 years: 2.4 mcg/dayPregnancy: 2.6 mcgLactation: 2.8 mcg Absorption of B12 Pepsin and hydrochloric acid (HCL) are necessary for cleaving B12 from protein in stomach.Individuals with low levels are at a greater risk of deficiency due to decreased break down for absorption.B12 supplements (crystalline B12) do not require HCL or pepsin to bind to intrinsic factor (IF).B12 supplements are absorbed normally in hypochlorhydria.Intrinsic factor (IF) is made in the stomach and necessary for carrying B12 from the stomach to intestines for absorption.Individuals with genetic SNPs impairing intrinsic factor (IF) production are also at a greater risk of deficiency and must rely on B12 injections, bypassing the need for IF.IF becomes fully saturated at 2 mcg of B12.Large doses can be absorbed through passive diffusion which doesn't require IF. This accounts for 1-2% of absorption.1000 mcg/day can overcome loss of IF due to pernicious anemia.Pernicious anemia is an autoimmune disease characterized by the destruction of parietal cells which produce IF. Possible Causes of Vitamin B12 Deficiency Pernicious anemia—Auto antibodies against parietal cells and IFGastric disease or surgeryChronic atrophic gastritis—parietal cell death/autoimmuneUse of gastric acid inhibitors (antacids, histamine receptor 2 antagonists, proton pump inhibitors)Pancreatic disease or pancreatectomyOther intestinal diseases: parasitic infections, bacterial overgrowth, ileal resection, impaired B12/IF absorption.Medications, such as cholestyramine and metformin, that impair B12 absorption or metabolism.Limited/poor food sources/choices that result in general malnutrition. Examples include vegan or vegetarian diet.Chronic alcoholismInherited disorders involved in B12 trafficking and metabolismMiscellaneous: including HIV and nitrous oxide anesthesiaConditions that result in chronic diarrhea or malabsorption states, such as celiac disease and Crohn's disease.Helicobacter pylori infection results in hypochlorhydria. Eradicating H Pylori can improve B12 levels.Long term psyllium supplementation (> 1 year)Genetic factors can affect absorption and transport. Individuals with genetically higher methylmalonic acid levels will require higher-than-normal B12 dose...

On this episode of Fundamental Health, Paul fields a wide variety of questions from attendees at the second annual Animal Based Gathering in Santa Teresa, Costa Rica. Time Stamps: 00:09:42 Podcast begins  00:10:30 How much protein we should eat as we age depending on how much we weigh and how much we move 00:16:00 Does eating excess liver cause copper toxicity or reduce stomach acid? 00:19:00 Should we change our diet even if we think we're thriving? 00:22:30 Can we be allergic to meat? 00:27:10 Is it okay for our LDL and triglycerides to rise when we increase our saturated fat? 00:34:50 Where can we get iodine aside from seafood and kelp? 00:39:00 Thoughts on high levels on deuterium in fruit 00:40:05 Suggestions on keeping tabs on breast cancer 00:43:45 Overcoming food sensitivity and thoughts on food sensitivity tests 00:47:10 Should we take supplements to heal through a lifestyle change? 00:51:16 Thoughts on low baseline sugar levels 00:56:10 Side effects of eggs and thoughts on eggs 00:59:10 Thought on antibiotics 1:04:30 Insulin resistance beginning in the fat cell 1:10:39 Is linoleic acid harmful in all foods? 1:12:30 Anecdote on skin healing  1:16:00 Sugars versus starches? 1:19:00 Methionine glycine balance and thoughts on bone broth 1:22:40 Does liver accumulate heavy metals? Should we be careful about sourcing for liver? 1:24:39 Thoughts on exposure to parasites 1:31:28 How to maintain animal based when on the go 1:33:30 Responding to clinicians that consider animal based disordered eating 1:37:05 Ketosis and mental illness 1:39:40 Speaking on the Animal Based family 1:44:50 Thoughts on remineralizing water and routine testing/labs 1:52:15 Longevity of our ancestors 1:58:42 How should we incorporate fruit and honey for ourselves and our kids? 2:01:40 Animal based eating for women's hormones and pregnancy Sponsors: White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order Sacred Hunting: sacredhunting.com/PAUL, get $250 off your hunt Lets Get Checked: 20% off your order at www.TRYLGC.com/carnivoremd Earth Runners: www.earthrunners.com, use code PAUL for 10% off your order 

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Part two of my three-part series with methylation expert Dr. Albert Mensah. 1:40 - Is it ever appropriate and/or helpful to combine pharmaceutical approaches with nutraceutical strategies for mental health in the context of methylation? 4:13 - SAMe – a natural SSRI? 7:35 - The SERT gene, SAMe, folate and various other ways one's methyl status impacts serotonin 10:20 - SAM to SAH ratio test: how and why this test can render actionable data http://www.doctorsdata.com/Methyla5on-Pro%EF%AC%81le-plasma (Methylation profile/SAM to SAH ratio test) 17:50 - Ways the SAM to SAH ratio test can become skewed 11:50 - What actually is homocysteine both in the context of methylation and in general? Do homocysteine levels correlate to methyl status? 26:15 - Glycine: have this amino acid's methyl-buffering effects been overstated? 28:50 - Methionine: the concerns over excess methionine. Overstated and out of context? 31:17 - Folate, folic acid and cancer 32:40 - Folate pathway via MTHFR. Is it the main pathway, as most “experts" would have you believe, or is it the backup pathway to re-methylating homocysteine? https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid)Mensahmedical.com Listen to the Accompanying Episode Here: https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939 (Methylation: A Primer to My interview with Dr. Albert Mensah)  Email ROTC@rootofthecause.net with your questions, episode requests or feedback.

Creatine is a naturally occurring molecule in your body that helps create cellular energy in exercising muscles, among other benefits. We debunk the common myths and discuss the science you need to know about creatine!  Support your Exercise and Fasting sessions with the new Electrolyte Stix from MYOXCIENCE Nutrition: bit.ly/electrolyte-stix Use code podcast at checkout to save at checkout  Link to research, video and images: http://bit.ly/creatine-science Time Stamps:  00:30 Creatine helps to add phosphorous groups to ADP molecules to remake ATP. ATP is needed to move your muscles. 00:55 The food you eat is broken down into ATP. 01:00 People retained water back in the day when creatine was paired with dextrose (sugar). 03:16 Creatine is a metabolite comprised of 3 amino acids. Arginine, which helps to vasodilate and increase blood flow, glycine, and methionine.  Glycine is part of the glutathione tripeptide. Methionine is a sulfur-containing amino acid. 04:15 You have over 100 grams of creatine in your body. It is found primarily in your muscle tissue because they are energetically demanding. 05:30 Some cuts of beef contain 9.6 mg/gram of dry weight of creatine. Beef is rich in creatine, taurine and carnosine. It also has beta alanine. 06:05 Wheat, soy, potato, and corn contain zero creatine, taurine, beta alanine, and carnosine. If you eat red meat, you are probably getting plenty of creatine. 07:00 ATP is fundamental to cellular processes that underpin skeletal muscle contraction during exercise. Muscle stores little ATP. Metabolic pathways are activated to maintain ATP resynthesis. 07:45 Creatine functions mainly at the muscle level. 09:00 Creatine supplementation can be a multifactorial intervention across the lifespan in women with little to no side effects.  Creatine is not an androgen. It is involved in energy utilization and recycling. 09:35 Creatine supplementation combined with exercise provides musculoskeletal and performance benefits in older adults. 10:10 Creatine paired with electrolytes can improve power output and strength, because it works during the workout. 11:10 Anaerobic power and strength is improved with creatine paired with electrolytes (magnesium, potassium, calcium, and sodium). There was a 10 to 15% benefit in the intervention group in the WWU study.Improvement/progress is motivating. 15:25 As you age, you naturally lose strength and muscle. Supplemental creatine may help counteract some of the strength loss. 15:55 Electrolytes like, magnesium, sodium, and potassium, are transporters used to aid in the absorption and utilization of creatine. 17:40 Creatine uptake is directly impacted by presence of sodium, chloride, and calcium. Creatine uptake is reduced by up to 47%, when there is no calcium or magnesium in extracellular fluid. When concentrations of sodium and chloride are increased, uptake increases, even with no additional creation concentrations. Sodium and chloride are both needed for transport. 19:10 Electrolytes are often taken after a sauna session or before, during or after a workout. Sauna moves a lot of blood in and out of your core.  

Today I'm doing a solo episode covering key concepts I discuss in my upcoming interview with one of the leading experts on methylation today, Dr. Albert Mensah. Dr. Mensah was in the game many years prior to the word methylation even becoming part of the functional medicine vernacular. He mentored under Dr. William Walsh, who started doing groundbreaking work on methylation in the mental health sphere decades before MTHFR became a trendy buzz term and years before methylation was at all talked about outside of academic circles. Dr. Mensah is part of this lineage of the great pioneers in the field of methylation research, and as such, you'll see that his knowledge in this area knows no bounds. With that said, I felt that doing a solo episode to provide some background information and a better understanding of some of the advanced concepts we discuss would be of value. Look for my three-part interview series with Dr. Mensah, which will be released in the coming weeks.  2:16 - Selective serotonin re-uptake inhibitor SSRI physiology 101 6:04 - How homocystein is biochemically made 7:30 - Methionine converting to S-adenosyl-L-methione (SAM) 8:03 - SAM converting to SAH 9:02 - The SAM to SAH ratio 9:55 - The methylation misconceptions of folate  12:14 - Selective serotonin reuptake enhancers  13:02 - gene polymorphism (SNP) 101 13:41 - Glycine in the context of methylation https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid) Email ROTC@rootofthecause.net with questions or requests for future episodes.