Podcasts about Methionine

Many horse owners focus on choosing the best hay, grain, or supplements, but research shows that when you feed can also impact how well your horse utilizes protein and amino acids.On this episode, co-hosts Dr. Tania Cubitt and Katy Starr and guest Dr. Sara Mastellar, equine nutrition researcher and professor at Ohio State ATI, break down her research on meal frequency and protein metabolism in horses, including:The difference between “just feeding protein” vs. ensuring your horse gets the right amino acidsWhy feeding multiple meals a day can improve your horse's nutrient absorptionSimple, practical ways to adjust your horse's feeding routine for better healthAs Dr. Mastellar mentions, “Observation is central to good horsemanship.” If you've ever wondered whether your feeding schedule is truly working for your horse, this is an episode you don't want to miss!

Have you tried countless topical acne remedies that haven't seemed to work? In this video, I'm going to show you how to get rid of acne fast, naturally! Find out how to get rid of acne overnight in this video. DATA:https://pmc.ncbi.nlm.nih.gov/articles... Today, I'm going to share one of the best acne remedies to help get rid of acne naturally and effectively. I discovered 4 patents that involved sulfur for acne, and I noticed countless sulfur creams on the market. So, what's the deal with sulfur for acne?Many people with acne are deficient in sulfur. Sulfur can help with acne removal because of the following benefits•Decreases inflammation •Increases hydration of the skin•Increases collagen•Helps regulate androgens •Helps regulate insulinGrains, sugar, seed oils, fructose, and alcohol can deplete sulfur. You get small amounts of sulfur from plants like garlic, onion, and cruciferous vegetables, but most of your sulfur comes from protein. Methionine and cysteine are the 2 amino acids that provide you with the most sulfur. After calcium and phosphorus, sulfur is the most abundant mineral in the body, so you need a lot of it!To increase sulfur and get rid of acne, consume the following foods:1. Eggs2. Fish3. Beef4. Lamb5. Cheese6. Organ meatsYou must also avoid sugar and starch, which will block the absorption of methionine and cysteine and decrease sulfur.Try increasing your intake of high-quality animal-based protein to get rid of acne fast. Let me know how it works!

Previously shared as a paid newsletter in May 2024. In previous newsletters, I've addressed many of the more common contributing factors to brain symptoms, including high pyrroles, copper-zinc imbalances, methylation imbalances, candida overgrowth, mast cell activation, mold and other forms of toxicity, and genetic variants, such as COMT and MAOA.Supplements can be needed to address each of these. Medication can also be necessary when treating mold and mast cell activation.But what happens when someone can't tolerate a supplement or medication because it worsens or creates new brain symptoms? Why, for example, could someone have problems tolerating B6 or SAMe or Methionine. Why might someone have problems with folate, niacinamide, glutathione, certain herbal treatments, antidepressants such as SSRIs, probiotics, antifungal medication or binders such as bentonite clay, activated charcoal, chlorella or cholestyramine?In this newsletter, I'll discuss:* Five common reasons a supplement or medication may worsen symptoms.* Specific supplements and medications that are more likely to do this.* How reactions may point to root causes.* Treatment steps that can improve tolerance.There can be a wide range of brain symptoms that can occur when someone is having an adverse reaction, such as fatigue, brain fog, depression, anxiety, agitation, and even psychosis or mania. I'll use “reactivity” to refer to this range of possibilities. While physical side effects can also occur, the focus here will be on brain symptoms.5 Common Reasons Supplements or Meds May Worsen Symptoms1. Immune ReactivityOur immune system is intertwined with our central nervous system. When our body's immune system reacts to a toxin, microbe, injury, or trauma, we can have inflammatory brain and physical symptoms.“Feel Like I'm Reacting to Everything” - Mast Cell ActivationIf someone is experiencing severe immune reactivity, such as mast cell activation, they may react to many supplements and medications, as well as triggers in their environment and stress. The number of triggers can help point to an exaggerated immune response. In my practice, this high immune reactivity is usually driven by mold toxicity.For many with this obstacle, starting very low and slow can prevent reactions. For others, interventions may be needed to lower immune reactivity and stabilize mast cells. This, however, can require certain supplements. For those who can't tolerate those treatments, limbic system retraining programs help calm the immune system so people can move forward more easily.Sensitivity & IntoleranceIt is possible to have immune sensitivity (or even allergy) to a supplement, though I find this less common. Herbal supplements, for example, which are high in salicylates, may cause symptoms in those with salicylate sensitivity. Certain probiotics have bacterial strains high in histamine. This is an issue for those with histamine intolerance.2. Too Much or Too Little Neurotransmitter ActivitySome people with brain symptoms have high neurotransmitter (NT) activity, and some have low. Common NT's include serotonin (5-HT), dopamine (DA), and norepinephrine (NE). I use the term “neurotransmitter activity” because it's not just about the amount of neurotransmitters present; it's also about the amount of receptors present that pick up NTs and remove them from the space between nerve cells.High Neurotransmitter ActivityToo much neurotransmitter activity can cause brain symptoms such as mania, psychosis, agitation, anxiety, panic, obsessions, compulsions, and hyperactivity. Reactions can occur if supplements or medications are given that further increase NT activity.Examples include:* Overmethylation* Slow COMT (involved in clearing DA and NE) and/or slow MAOA (involved in clearing 5HT, DA and NE)A variant on COMT and/or MAOA doesn't mean they are being expressed.What Increases Neurotransmitters?* SSRIs (Selective Serotonin Reuptake Inhibitor) increase serotonin activity* SNRIs (Serotonin and Norepinephrine Reuptake inhibitors) increase serotonin and norepinephrine activity.* Stimulant medications such as Ritalin and Adderall increase dopamine activity* SAMe and methionine increase serotonin and dopamine activityRemember that there can be times when there is a mixed picture, such as when someone is undermethylated and has a slow COMT.Low Neurotransmitter ActivityReactions can occur if supplements or medication decrease the neurotransmitter activity when it is already low. This could look like depression, apathy, fatigue, and brain fog.Examples include:* Undermethylation* Fast COMT (involved in clearing DA and NE) and/or fast MAOA (involved in clearing 5HT, DA and NE). The NTs are getting cleared too fast.What Decreases Neurotransmitters?* Folate, a nutrient that is good for a lot of people happens to be a big problem for many with psychiatric conditions. Most with underemethylation have low serotonin symptoms (depression and/or anxiety). While folate can help methylation, as an unfortunate aside, it can also further lower serotonin activity. Folate is in most multivitamins and B Complex vitamins. To learn more: Undermethylation, MTHFR & The Great Folate Debate.* Niacinamide can lowers DA and NE.Looking closely at someone's symptoms and traits and assessing methylation through bloodwork can help determine if NTs are too high, low, or mixed and what types of treatment to consider.3. Poor Detoxification or Toxic OverloadZincZinc is one of the most powerful tools I use in my work. Some people can easily tolerate it, while others can struggle. Here are some reasons someone may not tolerate zinc.* High copper—Zinc mobilizes copper. Moving too much copper at once can increase copper symptoms (anxiety, anger, hyperactivity, insomnia).* High toxicity—Zinc is a strong antioxidant. It is needed for the genetic expression of one of the most important antioxidants in our body, metallothionein.It took me 8 months to get my dose up to an optimal range, which is certainly not the norm. I unknowingly had significant mold toxicity at the time.When I start someone on zinc, I slowly build it up over 3-4 weeks. For some (like myself), even this is too fast.GlutathioneThis is the other major antioxidant. If someone is having difficulty tolerating it, they may have problems with detoxification and significant toxicity (metals, biotoxins like mold, and chemicals). These can start to be addressed in several other ways.BindersThese include bentonite clay, chlorella, activated charcoal, and cholestyramine. They bind toxins, especially mold toxins, in the GI tract. If they are started too quickly, the toxins they are supposed to remove get stirred up, which stirs up symptoms. When people say they can't tolerate certain binders, they usually weren't started low enough.There are others, but these are the most common in my experience.4. Underlying Microbial or Microbiome IssueB6B6 is very important for brain health. It is needed for making serotonin, dopamine, and GABA. We use it in all the Walsh nutrient protocols to varying degrees. In the last 10 years, we've seen a decrease in B6 tolerance. It's not clear why. I'm including it in this section because the reactivity is suspected to be related to the microbiome. Perhaps in recent years, we have had collective damage to our microbiomes from toxins and rising EMF exposure. We don't know.The good news is that P5P, the active form of B6, is usually well tolerated. In my practice, I rely heavily on P5P. I will occasionally use it in combination with B6 (if tolerated) for those with especially high pyrroles.Methionine and/or SAMeBoth are used, though usually not together, to help address undermethylation. I suspect candida or mold when someone is having difficulties tolerating either of these. These nutrients are usually better tolerated once candida and/or mold are addressed (or are starting to get addressed).5. Die-OffAnything that kills off microbes, such as candida or mold, can cause a “die off” of those microbes, release toxins, and worsen symptoms. Antifungal supplements, antifungal medication, and probiotics may cause this type of reactivity. Antifungal medications include nystatin, diflucan, itraconazole, and amphotericin B.Herbs and food-based supplements can have antimicrobial effects. Turmeric is one example. There are many others, so it's always worth checking. Worsening symptoms might point to an underlying fungal or other microbial overgrowth. It may also suggest that appropriate binders may be needed first.Addressing or preventing die-offs could mean supporting detoxification, starting binders if necessary, and, again, starting low and going slow.Antidepressants, interestingly, have been shown in labs to have antifungal effects. This does make me wonder if some people who can't tolerate them are having die-off.Root CausesKnowing someone's history of reactions can help point to underlying root causes.As you can see, there are typically ways to help someone tolerate and go on to benefit from a needed supplement or medication.As always, I welcome your thoughts and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Methionine is one of the most critical essential amino acids, involved in detoxification, DNA protection, and neurotransmitter production. But here's where it gets interesting—too much methionine has been linked to aging and disease, while too little can impair recovery, methylation, and cognitive function.In this fifth episode of our Essential Amino Acids Series, we explore:✅ How methionine supports liver detoxification and antioxidant production✅ The role of methionine in DNA protection, gene regulation, and cognitive function✅ Why methionine restriction is being studied for lifespan extension✅ Best food sources of methionine per 100g serving✅ The surprising connection between methionine and mental health

Discuss my thoughts on whether Dimethylglycine or Trimethylglycine is "better" for Homocysteine conversion to Methionine.This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources: https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/https://cen.acs.org/articles/82/i3/METHYLMERCURY-TOXICOLOGY-PROBED.html#:~:text=%22Glutathione%20can%20be%20pumped%20out,brain%20as%20methylmercury%2Dglutathione.%22https://pmc.ncbi.nlm.nih.gov/articles/PMC4540061/https://www.sciencedirect.com/science/article/pii/S0163725821001182https://www.sciencedirect.com/science/article/pii/S0163725821001182 Image Resource:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635095/ https://www.researchgate.net/figure/Overview-of-de-novo-glutathione-synthesis-Reduced-glutathione-or-GSH-is-a-tripeptide_fig2_5690064 https://lpi.oregonstate.edu/book/export/html/71 https://www.nature.com/articles/hr2011133 https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/methylenetetrahydrofolate-reductasehttps://chemtymology.co.uk/2020/11/27/cysteine-and-cystine/ https://fda.report/DailyMed/972f09a7-2aa1-4b1b-a6dc-2c4578a07803 https://www.thoughtco.com/definition-of-precipitate-604612 https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-p-benzoquinone-imine#section=3D-Conformer https://www.semanticscholar.org/paper/DRUG-METABOLISM-IN-THE-LIVER-Nguyen/4a29c6c4d433685a94b94602c012b8731cba5493https://pubchem.ncbi.nlm.nih.gov/compound/S-_Methylmercury_-L-Cysteine#section=2D-Structurehttps://keymerhealth.com/articles/seafood-mercury/https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://www.sciencedirect.com/science/article/abs/pii/S0304416519300133https://www.jbc.org/cms/10.1074/jbc.M111.265348/asset/822df563-eda2-4f48-a333-d01370a79e9c/main.assets/gr5_lrg.jpghttps://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065https://www.acs.org/molecule-of-the-week/archive/c/l-cysteine.htmlhttps://biologydictionary.net/glutamic-acid/https://www.researchgate.net/figure/An-overview-of-the-reaction-catalyzed-by-SHMT-and-its-context-in-the-folate-cycle-A-The_fig1_338995871https://pubchem.ncbi.nlm.nih.gov/compound/5-Methyltetrahydrofolate#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrofolic-acid#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/135398652#section=2D-Structure

In this solo episode of the Dr. Geo Prostate Podcast, Dr. Geo takes a deep dive into the long-debated question: Should you eat eggs? With rising egg prices sparking conversations, he explores the scientific evidence, nutritional benefits, and potential risks of egg consumption, especially in relation to prostate cancer and longevity.Dr. Geo shares insights from his years of research and clinical experience, debunking myths and providing practical takeaways on how to approach egg consumption for optimal health.Episode HighlightsAre eggs bad for prostate cancer? What the research really says.Methionine and choline – Two essential nutrients in eggs linked to both benefits and risks.How many eggs should you eat? The recommended safe intake.Egg types matter – Differences between caged, free-roaming, and pasture-raised eggs.Do eggs really raise cholesterol? The truth about dietary cholesterol and heart health.Protein and longevity – The role of eggs in maintaining muscle and metabolic health.The “Effort Day” approach – How to enjoy eggs without overconsumption.Nutrition research challenges – Why diet science is complex and often conflicting.Key TakeawayThere's no one-size-fits-all answer, but moderation is key. If you eat eggs, choosing pasture-raised eggs and limiting intake to two or three per week may be the best approach.If you found this episode valuable, don't forget to subscribe and leave a five-star review on Spotify and Apple Podcasts. Share it with friends, family, or anyone looking to take charge of their prostate health.Join Dr. Geo each week for expert insights, science-backed advice, and empowering conversations designed to help you live better with age. ----------------Thank you to our partnersThe ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that maintain the body in a fasting state.Special Offer: Thank you for listening, you can purchase the ProLon kit for just $148 by using this link.We'd also like to thank our partner AG1 by Athletic Greens. AG1 contains 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This special blend of ingredients supports your gut health, nervous system, immune system, energy, recovery, focus, and aging. All the essentials in one scoop. Enjoy AG1 by Athletic Greens.----------------Thanks for listening to this week's episode. Subscribe to The Dr. Geo YouTube Channel to get more content like this and learn how you can live better with age.You can also listen to this episode and future episodes of the Dr. Geo Podcast by clicking HERE.----------------Follow Dr. Geo on social media. Facebook,

In this episode of The Dairy Podcast Show, Chad Robbins, from Adisseo, discusses three essential topics for dairy producers: forage quality, the role of amino acids, and transition cow health. Drawing from his extensive industry experience, Chad offers practical advice on improving forage management, leveraging amino acid balancing for better milk production, and supporting cows during the transition period to maximize herd performance. Tune in now on your favorite platform!"Amino acid balancing is more than just a milk protein boost—it's about optimizing the overall health of the rumen."Meet the guest: Chad Robbins holds a Bachelor of Science in Biology from Huntington College and a Master's in Animal Science from the University of Tennessee-Knoxville. With over two decades of experience, Chad specializes in ruminant nutrition and currently serves as a Technical Sales Manager at Adisseo. His career spans roles in dairy consulting and feed management, equipping him with expertise in optimizing dairy cattle performance. What you'll learn:(00:00) Highlight(01:40) Introduction(05:05) Amino acid balancing(09:42) Forage quality(13:52) Milk Pay tool(18:14) Transition cow strategies(21:13) Methionine & reproduction(24:01) Final questionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo- Acepsis- Berg + Schmidt- Trouw Nutrition- Natural Biologics- Scoular- Priority IAC- dsm-firmenich- Diamond V- Protekta- Volac- SmaXtec- ICC

On most dairies, the big question is “How do I put more milk in the tank?”  One potential answer lies in improving persistency, or helping cows maintain milk production.

In this episode of The Pet Food Science Podcast Show, Dr. Michelina Crosbie from the University of Guelph shares her research on amino acid bioavailability in pet food. She talks about her innovative work on methionine in peas and chicken meals, shedding light on how this important amino acid influences metabolic processes in dogs. Dr. Crosbie also covers the challenges of using extruded diets and gives us a glimpse into the future of nutritional research for companion animals. Don't miss out on this fascinating conversation, available on all major platforms!"Bioavailability takes digestibility a step further, allowing us to quantify how much of an amino acid can actually be used in metabolic processes like protein synthesis."Meet the guest: Dr. Michelina Crosbie is a Research Assistant in Equine Physiology at the University of Guelph, with expertise in animal nutrition and educational development. She holds a Ph.D. in Canine Nutrition and an M.Sc. in Swine Nutrition from the University of Guelph. In her role, she contributes to research on amino acid bioavailability in pet food ingredients and provides mentorship to graduate students.What will you learn:(00:00) Highlight(01:15) Introduction(04:15) Amino acid bioavailability(07:15) Methionine & protein synthesis(17:15) Extruded diets(20:15) Bioavailability in pet food(23:15) Future of bioavailability research(25:17) Final QuestionsThe Pet Food Science Podcast Show is trusted and supported by innovative companies like:* Trouw Nutrition* Kemin- EW Nutrition- Alura- Symrise- Biorigin- ICC- Scoular- Corbion- ProAmpac

Send us a textTransform your understanding of amino acids with insights from Dr. Joel Bryn, a leading expert in biochemistry, physiology, and immunology. Discover the surprising impact that dietary choices on amino acids like methionine and glycine can have on longevity. Dr. Bryn shares groundbreaking research from the Orentreich Foundation, suggesting that a reduction in methionine intake and an increase in glycine might hold the key to a longer life. Prepare to challenge your preconceptions about what makes an amino acid "essential" as we uncover the significant health benefits of glycine.The episode takes a closer look at the often misunderstood term "non-essential" in the context of amino acids. Learn how glycine, despite being classified as non-essential, plays a vital role in managing inflammation and preventing chronic diseases like cancer, autism, and cardiovascular issues. Through Dr. Bryn's analysis, we explore how glycine deficiency impacts our health, particularly in younger generations, shedding light on modern health challenges. With analogies that simplify complex processes, this discussion reveals why rethinking our protein sources could be crucial for our well-being.The conversation with Dr. Bryn also navigates the historical and modern dietary landscape, emphasizing the importance of collagen-rich animal products to boost glycine intake. These age-old dietary habits might just be the key to combating the chronic inflammation pervasive in today's society. As we close out the episode, we reflect on how a balanced approach, centering on evidence-based nutrition, can lead to improved health outcomes. Tune in for a compelling narrative that intertwines scientific rigor with practical dietary advice, promising to reshape your view on nutrition and longevity.Support the show

This Real Science Exchange episode was recorded during a webinar, which was part of a series. Watch all the presentations from this series here: https://balchem.com/animal-nutrition-health/resources-categories/real-science-lecture-series/previous-lectures/page/10/Early in lactation, the cow is incapable of eating enough to meet her dramatically increased requirements. As the cow's intake decreases near calving, there are fewer nutrient contributions from dry matter intake and she must alter nutrient partitioning to meet her increased needs by mobilizing fat and muscle stores. (1:18)Triglycerides from fat stores are broken down into non-esterified fatty acids (NEFA) and glycerol. NEFA has two different fates in the postpartum cow: to the mammary gland as a precursor for milk fat synthesis, or to the liver to be oxidized for energy production. Glycerol enters the gluconeogenic pathway in the liver as a glucose precursor. (4:41)The capacity for the liver to use NEFA for energy is limited by the capacity of the TCA cycle. When the TCA cycle is at capacity, excess NEFA can either undergo incomplete oxidation to ketones or be repackaged back into triglycerides. If the capacity for other tissues to use ketones for energy is exceeded, then blood concentrations of ketones rise and negative outcomes from subclinical and clinical ketosis can occur. If triglycerides accumulate in the liver, negative outcomes associated with fatty liver can occur. Triglycerides can be transported out of the liver via very low-density lipoprotein (VLDL) export; however, VLDL export does not keep up with triglyceride concentration during the transition period in dairy cows, largely because of a limiting amount of phosphatidylcholine. (5:51)Dr. White describes a series of experiments in her lab using liver cells in culture to investigate the relationship between choline supplementation and VLDL export. As choline supplementation to the cell culture increased, so did VLDL export from the cells into the media. In addition, increasing choline supplementation to the cell culture also decreased cellular triglyceride content. (10:54)Using gene expression and radiolabeled tracers over a series of experiments, Dr. White's group found that as choline supplementation increased, so did complete oxidation of NEFA to energy. This was accompanied by decreased incomplete oxidation to ketone bodies and decreased accumulation of lipids in the liver cells. Glucose and glycogen were also increased with increasing choline supplementation to the cell culture, and a decrease in reactive oxygen species was observed. In addition, choline-supplemented cultures exhibited an increase in metabolic pathways associated with methionine regeneration and methyl donation. (15:29)Dr. White then details the complexity of the metabolic pathways that intersect between choline and methionine. In similar experiments supplementing cell cultures with increasing amounts of methionine and choline, there were no effects of methionine on lipid export, oxidative pathways, or glucose metabolism. The main benefit of methionine was a marked increase in glutathione production. It's important to note that no interactions between choline and methionine were observed in this series of experiments. (19:37)There seems to be a clear biological priority for different sets of pathways for choline and methionine. Choline seems to be influencing lipid, glucose, and oxidative pathways, while methionine is primarily serving its role as an essential amino acid for cellular protein structure and generation, acting as a methyl donor, and impacting inflammation. Importantly, both the choline and methionine results observed in cell culture are paralleled in transition dairy cow studies. (24:14)Dr. White's lab further investigated the impact of methionine on inflammation. When cells were challenged with LPS to provoke an inflammatory response, methionine mitigated the inflammatory response. Similar results have been observed in liver tissue samples of transition cows. Methionine mitigated inflammatory markers and increased glutathione but did not influence reactive oxygen species. Conversely, choline decreased reactive oxygen species but did not change glutathione. (27:47)Choline and methionine are both essential nutrients, there are biological priorities for them as methyl donors, and they are not mutually exchangeable. The lack of interaction between choline and methionine in vivo or in vitro supports the idea of different biological roles for these nutrients. (32:09)Dr. White takes questions from the webinar audience. (34:53)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Hello there!In this episode of The Dairy Podcast Show, Dr. Kraig Peel, from Adisseo, explores the role of amino acid balancing—especially methionine—in enhancing reproductive health and boosting production efficiency in dairy cows. Dr. Peel breaks down how optimizing methionine levels can significantly impact fertility and overall herd performance, offering practical strategies to improve herd health and productivity. Listen now!"We see immediate results in dairy cattle when we add protected methionine to their diets, which can impact milk protein production right away."Meet the guest: Dr. Kraig Peel, currently a Technical Support Specialist at Adisseo, holds a master's and Ph.D. in animal science from Texas A&M University. With expertise in animal nutrition, reproduction, health, and welfare—especially in cattle—Dr. Peel's extensive background spans academic roles and field consulting, where he advises on scientific applications for dairy cattle health and production.What you'll learn:(00:00) Highlight(00:38) Introduction(01:05) Professional background(06:52) Bypass amino acids(09:40) Methionine's role(11:37) Reproductive health(13:33) Consulting challenges(19:11) Final three questionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Adisseo- SmaXtec- Acepsis- Trouw Nutrition- Protekta- Natural Biologics- dsm-firmenich- ICC- Berg + Schmidt- Diamond V- Volac

Hello there!In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Lucas Rebelo discusses the impact of methionine on milk fat production. Dr. Rebelo elaborates on how methionine upregulates enzymes that promote fatty acid synthesis, particularly in Holstein cows. He also touches on the challenges and future research directions in this area. Tune in to explore cutting-edge insights into optimizing milk fat content through amino acid supplementation."Amino acids like methionine exert an effect on milk fat through the upregulation of transcription factors or enzymes associated with de novo fatty acid synthesis."Meet the guest: Dr. Lucas Rocha Rebelo is a Dairy Technical Manager at Adisseo with a strong background in dairy nutrition and environmental science. He earned his Ph.D. from The Ohio State University, where he researched amino acid metabolism in dairy cows. Dr. Rebelo also holds an M.Sc. in Ruminant Nutrition from Universidade Estadual Paulista and a B.Sc. in Animal Science from the Federal University of Mato Grosso.What will you learn: (00:00) Highlight(01:10) Introduction(01:56) Methionine's effect on milk fat(02:54) Supplementation rates and responses(04:16) Mode of action of methionine(06:41) Dietary interactions with methionine(08:10) Research on other amino acids(09:51) Closing thoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Virtus Nutrition- Evonik- Volac

This episode comes to you from the 2024 Tri-State Dairy Nutrition Conference, where Balchem sponsored a Real Science symposium titled “New Discussions in Amino Acid Nutrition.” Each of our guests presented at the symposium, and their presentations can be found at balchem.com/realsciencemediaDr. Van Amburgh presented “Amino Acid Nutrition for Maximizing Milk Component Yield.” When considering nitrogen efficiency, we generally compare intake nitrogen, which includes non-protein nitrogen, against milk nitrogen. In high producing cows, aggregate amino acid values are running about 70 to 73% efficiency. But when we work that up to total intake nitrogen, then we're down to 30 to 35% efficiency range. How do we reconcile ruminal nitrogen requirements to a point where we can optimize the capture of recycled nitrogen and reduce the amount of nitrogen that's being excreted in the urine? (2:27)Dr. Hanigan presented “Understanding Amino Acid Bioavailability.” Our current methods for measuring bioavailability don't all have the same precision. One of the classic methods, intestinal disappearance, has very low precision. Methods that rely on dilution of a marker or a label in blood or milk have much higher precision. Dr. Hanigan's lab has worked to modify a carbon-13 labeled amino acid method to allow for evaluating changes in the supply of amino acids in the diet.  (5:01)Dr. Lee presented “Current Understandings of Lysine Nutrition in Dairy Cattle.” Rumen-protected lysine has more variable responses than rumen-protected methionine or histidine. Amino acid requirements were developed based on the role of amino acids as the building blocks of protein. But there are many roles of amino acids which may influence their requirements. Dr. Lee suggests including that type of information in our modeling may increase the consistency of responses to feeding rumen-protected lysine. (11:24)Dr. Hristov presented “Histidine: A Limiting Amino Acid for Dairy Cows.” His group has worked with rumen-protected histidine to develop a dataset to define requirements. Microbial protein has considerably less histidine than methionine yet they are secreted at about the same level in milk and are metabolized similarly. All this together points to a higher histidine requirement. (18:02)The panelists agree that the advent of genomics have resulted in a rapid change in high producing cows and with that, their amino acid requirements (and other nutrients) are also changing. It's a challenge for feeding and nutrition programs to keep up with rapid genetic change. (21:02)A question was posed by the audience about how Dr. Van Amburgh used amino acids to increase butter fat. In the research he presented, the diets did not overfeed fat and fed a blend of fatty acids, and also increased the sugar and pulled back the starch. (28:35)A discussion of histidine follows, including its unique body reserves, its role in hemoglobin concentrations, and its potential impacts on metabolic energy efficiency (34:08)Dr. Zimmerman asks about plasma histidine in very early lactation cows. Dr. Hristov is currently conducting a fresh cow experiment to assess this. His hypothesis is that because of low dry matter intake and high metabolic demand for amino acids, there will be a response to histidine supplementation. Dr. Lee agrees and feels that the fresh cow stage may be one of the most practical ways we can utilize rumen-protected histidine (39:39)A question from the audience about the use of blood meal in lower protein diets sparks a spirited discussion among the panelists. (41:55)In closing, each panelist provides a takeaway. Responses range from bioavailability of rumen-protected products to challenges to progress for ruminant amino acid research to comparing biological potential and economic response. (46:58)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Danielle Sherlock explores the interactions between heat stress, rumen-protected methionine, and immune function in dairy cattle. She discussed how supplementation can mitigate the negative impacts of heat stress on immune function and overall metabolism. Tune in on major platforms to discover how these findings can transform dairy cattle management."Methionine supplementation helps to overcome negative effects of the transition period on immune function and oxidative stress."Meet the guest: Dr. Danielle Sherlock is the Ruminant Research and Innovation Science Manager at Adisseo. She has a rich academic background from Ohio State University and the University of Illinois. Her Ph.D. research concentrated on the metabolism of methyl donors, particularly under conditions of heat stress and negative energy balance in dairy cows. Dr. Sherlock's work offers valuable insights into nutritional strategies that enhance dairy cow health and productivity during stress periods.What will you learn: (00:00) Highlight(00:55) Introduction(02:19) Heat stress and immune cell activation(03:35) Effects of heat stress on metabolism(04:45) Insulin sensitivity under heat stress(06:31) Heat stress and immune function(07:19) Discussing methionine supplementation(08:19) Closing thoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Volac

Amino acid balancing plays a crucial role in enhancing feed efficiency, promoting cow health, and increasing milk production in the dairy cattle industry. Join Franck Gaudin as he delves into the latest trends and insights, uncovering the keys to improving dairy production and maintaining optimal health in cows."Amino acid balancing is crucial in dairy nutrition, leading to better milk quality and cow health."Meet the guest: Franck Gaudin, Dairy Business Director at Big Gain Feed Inc., brings extensive expertise to the dairy industry. Based in Lakeville, Minnesota, he plays a pivotal role at Big Gain, an esteemed agriculture company founded in 1973. With a dedicated team, Franck leads with innovation and a deep understanding of dairy business dynamics.What you'll learn:(00:00) Highlight(00:56) Introduction(01:59) Results and benefits of amino acid balancing(02:37) Link between milk protein and cow health(03:32) Methionine's role in dairy production(03:47) Broader influence of amino acids(04:30) Future potential in amino acid balancing(05:52) Closing thoughts and conclusionThis Dairy Podcast Show Episode is trusted and supported by:* AdisseoAre you ready to unleash the podcasting potential of your company? wisenetix.co/custom-podcast

In this episode of The Dairy Nutrition Blackbelt Podcast, Dr. Phil Cardoso, an Associate Professor from the University of Illinois, explores the innovative approaches in dairy nutrition, focusing on integrating nutrition and reproduction. Dr. Cardoso approaches the pivotal role of Rumen-protected methionine in enhancing transition cows' health, examining its impact on protein synthesis, milk protein, and reproductive performance. Insightful discussions extend to its effects on calves' immune responses and placenta changes, underscoring the nuanced relationship between nutrition and dairy cow well-being. Tune into this episode on all major platforms to understand how strategic nutrition management can significantly influence dairy production outcomes.“We super-ovulated those cows, we harvested the embryos, and we saw some differences there.” - Dr. Phil CardosoMeet the guest: Dr. Phil Cardoso, an Associate Professor at the University of Illinois since 2012, specializes in the intersection of dairy nutrition and reproduction. His work, pivotal in understanding the nutritional nuances that influence dairy cow and calf health, provides invaluable insights into improving dairy production through strategic nutrition management. What will you learn: (00:00) Highlight(00:38) Introduction(01:02) Role of Rumen-Protected Methionine(01:53) Impact on Reproduction and Embryo Growth(04:00) Supplementation Protocol(06:06) Nutritional Strategies and Protein Synthesis(08:20) Colostrum Quality and Amino Acid Impact(08:28) Closing ThoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Volac

In this episode of The Dairy Nutrition Blackbelt Podcast, we welcome Dr. Danielle Sherlock, a Ruminant Science Manager at Adisseo and a distinguished researcher with extensive experience in dairy cow metabolism under stress conditions. Dr. Sherlock discusses the benefits of rumen-protected methionine during heat stress in dairy cows, based on recent research findings. This conversation is vital for anyone in the dairy industry seeking to understand and mitigate the impacts of heat stress on cow metabolism and milk production. Tune in on major platforms to explore innovative strategies for enhancing dairy cow health and productivity.“We knew in transition cows that methionine has a lot of effects beyond just being used for protein synthesis and production.” - Dr. Danielle SherlockMeet the guest: Dr. Danielle Sherlock is the Ruminant Science Manager at Adisseo, with a rich academic background from Ohio State University and the University of Illinois. Her Ph.D. research concentrated on the metabolism of methyl donors, particularly under conditions of heat stress and negative energy balance in dairy cows. Dr. Sherlock's work offers valuable insights into nutritional strategies that enhance dairy cow health and productivity during stress periods.What will you learn: (00:00) Highlight(00:36) Introduction with Dr. Bill Weiss(01:10) Overview of Dairy Cow Metabolism Research(04:15) Heat Stress Effects on Cows(05:17) Behavioral Changes in Heat-Stressed Cows(06:45) Milk Composition and Methionine(07:52) Supplementation Strategies for Heat Stress(08:45) Closing ThoughtsThe Dairy Nutrition Blackbelt Podcast is trusted and supported by the innovative companies:* Adisseo- Volac

In this week's episode we'll report on the findings from a study evaluating the long-term outcomes of pulmonary embolism in children and adolescents, discuss a new mechanism for hereditary angioedema caused by a methionine-379 to lysine substitution in kininogens, and learn more about predictors of unsustained minimal residual disease negativity in multiple myeloma patients.

Today, we will be learning why our muscular skeletal system may be out most important organ we have and how a Muscle-Centric Nutrition approach contributes to our to health and longevity and can preventing obesity, and other health issues such as cancer. We'll be looking at the essential roles that protein and amino acids play, optimal dietary protein needs, ideal timing of protein intake, best sources, and everything we need to know about protein synthesis.  My guest is Don Layman, Professor of Food Science and Human Nutrition at one of the top agriculture colleges in the world, the University of Illinois Urbana-Champaign College of Agricultural.   Don earned his B.S. in Chemistry and M.S. in Biochemistry at Illinois State University and his Ph.D. in Human  Nutrition and Biochemistry at the University of Minnesota, St. Paul.   His research focuses on understanding the protein and amino acid requirements and interrelationship between dietary protein and carbohydrates needed for adult health.   In particular, his research seeks to understand the impact of diet and exercise on obesity, type 2 diabetes, and metabolic syndrome in adults.  His work has helped to define the role of branched chain amino acids (BCAA) in skeletal muscle metabolism.   BCAA provide an important energy source for muscle during exercise and also serve as a critical regulator of muscle protein synthesis during recovery.  During exercise, oxidation of BCAA increases, resulting in production of the amino acid alanine and a rapid decline in plasma levels of BCAA.  Amino acid supplements prevent this decline in plasma amino acids, enhance recovery of muscle protein synthesis and interact with insulin to help stabilize blood glucose.  His research continues to define mechanisms for control of muscle protein synthesis and differences in dietary protein needs for men versus women and for adults with sedentary versus active lifestyles.  He's dedicated over 40 years investigating the intricate role of dietary protein in muscle protein synthesis and the impact of diet and exercise on obesity, type 2 diabetes, and metabolic syndrome in adults.  His research has significantly contributed to our understanding of the interplay between nutrition, muscle health, and overall well- being.  Well Learn: The Basics of Protein and Amino Acids and their role in Nutrition Why Leucine, Lysine, and Methionine are Essential Amino Acids and foods we get them from Key things we need to know about protein synthesis Recommended Dietary Allowance (RDA) for Protein, how it was calculated and why it's not optimal The optimal amount of protein we need based on Don nLayman research How the size and frequency of meals impacts muscle protein synthesis Small meals versus big meals? Specifics around protein intake that should be followed with time restricted eating. How to track their protein intake effectively How to determine the quality of protein sources, what are our best sources And how factors like absorption rates play a role in protein source selection Don Laymans thoughts on plant-based and synthetic "meats" in the market from a nutritional standpoint High Protein Diets for Fat Loss - Results from Clinical Trials Consequences of Protein Deficiency in Childhood, how it impacts long term health Optimal protein intake amounts for a child Saturated fat and our health Muscle-Centric Nutrition Philosophy The significance of our muscular skeletal system to health, longevity, preventing obesity, and other health issues such as cancer Role of Muscle in Glucose Storage and Insulin Resistance The connection between muscle health, insulin resistance, and the development of diabetes    **To donate/tip our channel, below through our Paypal. Paypal Donation Link: https://www.paypal.com/donate/?hosted_button_id=6YECDNX33L4KQ   DTH Mailing List: https://mailchi.mp/a285090e8123/discovering-true-health-mailing-list Frequency Healing Device: https://us.healy.shop/?partnername=5058-6574-1579   Links for Don Layman Ph.D. Web sight: metabolictransformation.com Bio and Research: https://fshn.illinois.edu/directory/dlayman Twitter: @donlayman   Stay In Touch with Us! Instagram:   @DiscoveringTrueHealth Twitter:        @DTrueHealth  Facebook:   @discoveringtruhealth Rumble:       Discoveringtruehealth   Listen On:  Apple Podcast Spotify   Watch On: YouTube   www.discoveringtruehealth.com     Medical disclaimer: Discovering True Health LLC does not provide medical advice. Discovering True Health and the content available on Discovering True Health's properties (discoveringtruehealth.com, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.          

Dr. Räisänen completed this research during her Ph.D. at Penn State. The meta-analysis included 17 different studies published between 1999 and 2022 investigating supplemental histidine for lactating dairy cows. They divided the type of supplemental histidine between infused histidine and rumen-protected histidine and the basal diets between corn silage-based and grass silage-based. (4:34)Primary response variables measured in the meta-analysis included dry matter intake, milk production, milk composition, and milk component yields. The researchers also calculated the efficiency of utilization of histidine and other amino acids supplied to the cow by the diets. Lastly, they calculated marginal recovery of histidine and evaluated the interaction between histidine supply and energy supply and how that impacts the efficiency of utilization. (7:38)Dr. Lapierre gives a little history of histidine research. When recommendations were coming out about lysine and methionine requirements, the different studies recommended relatively similar amounts of lysine and methionine based on the proportion relative to MP supply. On the other hand, recommendations for histidine varied widely depending on the study, ranging from less than 2% to almost 4%. As emphasis has been placed on reducing the footprint of dairy production, interest has risen in feeding lower-protein diets. In this scenario, we would expect an increase in the microbial protein; however, microbes are relatively low in histidine content. If we look at the proportion of histidine relative to MP, as the crude protein concentration of a diet decreases, this proportion of histidine decreases. (8:34)The meta-analysis revealed a clear response to histidine in milk production, dry matter intake, and milk true protein yield. Susanna and Helene are not sure if the dry matter intake response was due to a pulling effect because of increased milk and milk protein yield or if histidine has an independent impact on the brain, as has been observed in some monogastric studies (16:15)Clay asks the guests what they think the histidine requirement is, and both agree that providing one number is not practical given the other interactions from basal diet to the efficiency of utilization to the concentration of other amino acids in the diet. (32:01)Practical implications from the meta-analysis include an understanding that lower protein diets may very well need supplemental histidine for optimum performance, and cows pay a penalty when inadequate histidine is supplied. (35:09)Helene's take-home message is that histidine should be taken seriously. If you don't supply enough of it, then you'll have a penalty in your cows' production. Further, the efficiency of histidine utilization will be affected by the energy supply, and we have tools with NASEM to assess if a herd is receiving sufficient histidine. Susanna echoes Helene's message and adds that a rumen-protected histidine product on the market would be very helpful. (45:35)The paper can be found here: https://www.journalofdairyscience.org/article/S0022-0302(23)00416-2/fulltextPlease subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

On this episode, co-hosts Dr. Tania Cubitt and Katy Starr discuss the topline of horses including:The most common reasons for a poor topline in horsesTips to improve a horse's topline with nutritionSpecific nutrients that impact a horse's toplinePoor topline in horses is a common concern among horse owners, so this topic will be sure to provoke considerable interest! Send this to someone you think would benefit from this episode.Have a topic idea or feedback to share? We want to connect with you! Email podcast@standlee.com____________________________________ Additional Resources or References during this episode – 3:30 – Body Condition Scoring System3:56 – Cresty Neck Scoring System“Cresty Neck – A Precursor to Metabolic Disease in Horses” blog post - https://www.standleeforage.com/standlee-barn-bulletin/cresty-neck-a-precursor-to-metabolic-disease-in-horses/“Ep. 057: How to Prevent and Manage Laminitis” podcast episode - https://www.standleeforage.com/podcast/episodes/ep-057-how-to-prevent-and-manage-laminitis/“Ep. 052: Why Your Horse is Overweight, and You Probably Don't Know It” podcast episode - https://www.standleeforage.com/podcast/episodes/ep-052-why-your-horse-is-overweight-and-you-probably-dont-know-it/4:24 – Development of an equine muscle condition score (initial research on muscle conditioning in 25 thoroughbred horses) - https://beva.onlinelibrary.wiley.com/doi/full/10.1111/eve.1377712:58 – Refeeding Syndrome and how to safely feed a neglected, starving rescue horse – chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://ceh.vetmed.ucdavis.edu/sites/g/files/dgvnsk4536/files/local_resources/pdfs/pubs-July2012-bkm-sec.pdf“How Can I Safely Feed a Neglected/Starved Horse Back to Health?” webinar - https://www.standleeforage.com/nutrition/nutritional-webinars/safely-feed-a-neglected-horse-back-to-health/32:15 – “Myth or Fact? Horses Can't Digest Oils” podcast episode - https://www.standleeforage.com/podcast/episodes/ep-0012-myth-or-fact-horses-cant-digest-oils/____________________________________Love the podcast? Leave a rating and review on Apple – https://podcasts.apple.com/.../beyond-the-barn/id1541221306Leave a rating on Spotify – https://open.spotify.com/show/3dmftQmwLKDQNueUcCJBZaHave a topic idea or feedback to share? We want to connect with you! Email podcast@standlee.comShare our podcast and learn more about our co-hosts at our Beyond the Barn podcast pageSUBSCRIBE to the Beyond the Barn podcast email to be an exclusive insider!Find us on Apple, Spotify or Google Podcasts and SUBSCRIBE, so you never miss an episode.____________________________________Check out the Standlee Barn Bulletin BlogFind more nutritional resources from Dr. Stephen Duren and Dr. Tania Cubitt at https://www.standleeforage.com/nutrition/nutritional-resources/Connect with Standlee on Facebook, Instagram, YouTube and TikTok____________________________________*Views and opinions expressed by guests are their own and do not necessarily reflect the view of Standlee Premium Products, LLC.*

The MTHFR gene error can lead to a host of deficiencies that ripple through your health, impacting everything from your liver to your mood. A deficiency in the essential amino acid Methionine, for example, can manifest in elevated cholesterol, liver issues, and even dementia. This deficiency is closely linked with low levels of SAM-e, a crucial molecule in the body, and can inhibit the recycling of Glutathione, the body's master antioxidant. Further complicating the picture are the roles of various B vitamins like B12, B9 (Folate), B6, and B2. An MTHFR gene error can disrupt these vital nutrients, leading to extreme fatigue, mood changes, and a cascade of other symptoms, including anemia and neuropathy. The gene error also affects the production of other important molecules and amino acids like L-Serine, which is critical for central nervous system function and Glutathione production. All told, the MTHFR gene error can have a far-reaching impact on your overall health.

Timestamps: 01:40 Glycine and Methionine for Longevity 10:45 Risks of High Homocysteine 15:10 Why You Need Glycine 19:45 How Bad Is High Homocysteine 22:45 Optimal Protein Ratios 26:35 How Much Glycine to Take 31:57 Can Taurine Extend Lifespan 38:15 Finding Your Genetic Bottlenecks 44:08 Power of Genetics 45:26 Is MTHFR Important 55:18 How to Find Your Genetic Bottlenecks 01:00:15 Whole Genome Sequencing 01:06:35 How Important Are Your Bottlenecks 01:09:11 How to Get Your Whle Genome Sequenced 01:11:40 What to Focus on For Longevity Chris Masterjohn YouTube channel: https://www.youtube.com/@chrismasterjohn Use code SIIM https://donotage.org/ref/Siim%20Land/ to get an extra 10% discount

A new research paper was published in Aging (Aging-US) Volume 15, Issue 11, entitled, “Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice.” Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. In this new study, researchers Yutaro Kubota, Qinghong Han, Jose Reynoso, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Michael Bouvet, Takuya Tsunoda, and Robert M. Hoffman from AntiCancer Inc., University of California San Diego and Showa University School of Medicine observed C57BL/6 mice double their body weight from 4 to 48 weeks of age and become obese. The team then evaluated the efficacy of oral administration of recombinant-methioninase (rMETase)-producing E. coli (E. coli JM109-rMETase) or a methionine-deficient diet to reverse old-age-induced obesity in C57BL/6 mice. “In the present study we tested a low-methionine diet to reverse old-age-induced obesity. [...] E. coli JM109-rMETase was also tested in the present study to reverse old-age-induced obesity.” Fifteen C57BL/6 male mice aged 12–18 months with old-age-induced obesity were divided into three groups. Group 1 was given a normal diet supplemented with non-recombinant E. coli JM109 cells orally by gavage twice daily; Group 2 was given a normal diet supplemented with recombinant E. coli JM109-rMETase cells by gavage twice daily; and Group 3 was given a methionine-deficient diet without treatment. The administration of E. coli JM109-rMETase or a methionine-deficient diet reduced the blood methionine level and reversed old-age-induced obesity with significant weight loss by 14 days. There was a negative correlation between methionine levels and negative body weight change. Although the degree of efficacy was higher in the methionine-deficient diet group than in the E. coli JM109-rMETase group, the present findings suggested that oral administration of E. coli JM109-rMETase, as well as a methionine-deficient diet, are effective in reversing old-age-induced obesity. “In conclusion, the present study provides evidence that restricting methionine by either a low-methionine diet or E. coli JM109-rMETase has clinical potential to treat old-age-induced obesity.” DOI - https://doi.org/10.18632/aging.204783 Corresponding author - Robert M. Hoffman - all@anticancer.com Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204783 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, obesity, methionine restriction, methionine-deficient diet, recombinant methioninase (rMETase), Escherichia coli, microbiome, weight-loss About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

We are excited to bring to you our brand new podcast, the Pet Food Science Podcast! This is where we dive deep into the world of pet nutrition alongside the brightest minds in the global pet food industry – all of it available right in your pocket! In our very first episode, Dr. Julia Pezzalli shares her findings on the amino acid requirements for cats. She also emphasizes methionine and introduces the indicator amino acid oxidation (IAAO) method, which helps determine protein quality, assess amino acid requirements, and optimize protein intake for specific needs. Furthermore, we go into some changes there have been to pet nutrition over time, some interesting insights about the relationship between the owner and pet nutrition, and important specific fat acids for pets."We need to make efforts to address protein quality, including the ratio of amino acids, even though that can be a challenge with dogs and cats due to the use of varied processing techniques." - Dr. Julia Pezzali(00:00) Highlight(01:00) Introduction(02:24) Methionine requirements for cats and the IAAO technique(10:08) Protein quality and amino acid ratios for pets(12:22) Changes in pet nutrition over time(16:50) How diet influences gut microbes and indirectly affects digestion(20:18) The relationship between owners and the well-being of their pets(22:03) Specific fatty acids in pet nutrition(25:09) Final considerationsMeet the guest: Dr. Julia PezzaliExperience:Assistant Professor (Iowa State University)Background:Ph.D., Cat Nutrition and Metabolism (University of Guelph - Canada)M.Sc., Pet Food Processing and Dog Nutrition (Kansas State University - US)B.Sc., Veterinary Medicine (Federal University of Rio Grande do Sul - Brazil)Connect with the guest!

Dr. Amber Harris author of "d,l-Methionine in combination with amoxicillin–clavulanic acid successfully dissolves spontaneously occurring infection-induced struvite urocystoliths in dogs: a pilot study in: Journal of the American Veterinary Medical Association - Ahead of print (avma.org)" discusses how d,l-methionine and amoxicillin–clavulanic acid can be used without changing diet for dissolution of infection-induced struvite urocystoliths in dogs. Hosted by Associate Editor Dr. Sarah Wright and Editor-in-Chief Dr. Lisa Fortier.INTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA OR AJVR?JAVMA: https://avma.org/JAVMAAuthorsAJVR: https://avma.org/AJVRAuthorsFOLLOW US:JAVMA:Facebook: Journal of the American Veterinary Medical Association - JAVMA | FacebookInstagram: JAVMA (@avma_javma) • Instagram photos and videosTwitter: JAVMA (@AVMAJAVMA) / Twitter AJVR: Facebook: American Journal of Veterinary Research - AJVR | FacebookInstagram: AJVR (@ajvroa) • Instagram photos and videosTwitter: AJVR (@AJVROA) / TwitterJAVMA and AJVR LinkedIn: https://linkedin.com/company/avma-journals#VeterinaryVertexPodcast #JAVMA #AJVRINTERESTED IN SUBMITTING YOUR MANUSCRIPT TO JAVMA ® OR AJVR ® ? JAVMA ® : https://avma.org/JAVMAAuthors AJVR ® : https://avma.org/AJVRAuthorsFOLLOW US:JAVMA ® : Facebook: Journal of the American Veterinary Medical Association - JAVMA | Facebook Instagram: JAVMA (@avma_javma) • Instagram photos and videos Twitter: JAVMA (@AVMAJAVMA) / Twitter AJVR ® : Facebook: American Journal of Veterinary Research - AJVR | Facebook Instagram: AJVR (@ajvroa) • Instagram photos and videos Twitter: AJVR (@AJVROA) / Twitter JAVMA ® and AJVR ® LinkedIn: https://linkedin.com/company/avma-journals

My guest this week has been ALL OVER the news cycle. A man who spends $2M on his body to age backwards!!!??? If you could age backwards, how would you do it? And not just your face (but that too) but each and EVERY organ in your body! What's the multi-millionaire version and what's the accessible version?  This week I'm talking to Oliver Zolman MD, he's the doctor of Bryan Johnson, a tech millionaire who, indeed, spends $2M a year on trying to age backwards. What's the science about aging and aging backwards? Is it possible and what's the latest? Oliver talks to me about the latest in dietary science (eating to stay young), the skin science (how to look young) and SO much more. He is a true wealth of knowledge! And checkout Magnesium Breakthrough by BiOptimizers for an exclusive offer at magbreakthrough.com/zaddy. In addition to the discount you get by using promo code zaddy, you can unlock special gifts with purchase with retail values of at least 20 dollars. Athletic Greens giving a FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase. All you have to do is visit athleticgreens.com/zaddy. You can find him at: IG YouTubeLinkedinhttps://www.oliverzolman.com/ Subscribe or keep tuning in at: IGTik toklukecook.comNewsletter INTRO 2:15Background, back problems, med school. His goal is disease modifying therapy for aging. 3:30His Client - Brian Johnson - who's spending millions of dollars to be an 18 year old again.The reversal of aging and how his approach differs. 5:30How young are Brian's organs?His heart rate variability is down 15yrs.Heart rate variability is…Why it's valid and valuable as a marker. How you can measure yours. 9:00Reducing stress & HRV rejuvenation causality.How they clinically measure.Caloric intake as it relates to longevity and HRV.Brian offsets his vegan diet with collagen peptides.How you can monitor your vitamins and minerals to increase longevity. 13:20Vegan or not to vegan - in the search for preservation.Core things to consume and avoid on his list, more on his website that we mention at the end.Caloric restriction with Omega 3, Omega 6, Trans Fats.ALA, DHA, EPA. 18:45Ways to get into a healthy caloric deficit. 21:00Fasting. Case study and its effects. Why it's less effective.Monkey Centenarians. 24:35Skincare: Millionaire Version & Cheap Version.Topical therapies.What skin is made up of and filling the fat gaps. 28:20Brian has donated his body to science.The least invasive, most effective lasers.IPL & BBL.Collagen Induction & Micro-needling. 31:43More on, collagen supplementation.Protein and AGF1 levels.Glycine to offset Methionine.  36:14More skincare.UV A&B wide wavelength filters.Sun exposure.Vit D.Lycopene.  40:50Ablative lasers.His tanning guidelines and dangerous tanning options.The lack of knowledge on the new tanning peptides and drugs. 47:30Recommendations for skin treatments that are less expensive.SculptraProfiloPRF 50:40TEETH! Keep ‘em young.Flossing, always flossing.Tea Tree Oil.Lithium water.Rates of suicide and correlatives with lithium natural spring water. 56:15The next ten years, what's in store for the future.Longevity School - it'll be available to everyone soon, it's currently for clinical study.See omnystudio.com/listener for privacy information.

Go to https://thld.co/zbiotics_siim_0123 and get 15% off your first order of ZBiotics Pre-Alcohol Probiotic by using my code SIIM at checkout. Thanks to ZBiotics for sponsoring today's video! Timestamps: 01:11 Thoughts on L-Theanine 02:27 Glycine vs Inositol for Sleep 03:30 Is Viagra Longevity Drug? 05:00 Thoughts on Finasteride 07:50 Glycine with Methionine or Alone 08:36 Carbs First Or Protein First 10:25 Do I Use Nicotine 11:25 How Much Magnesium Can Your Body Absorb 12:52 L-Theanine vs Tyrosine 14:00 How to Increase HRV 16:00 Best Non-Dairy Calcium Sources 16:43 Potatoes Fried in Olive Oil - Good or Bad 18:00 Vitamin C and Garlic Pre-Workout 20:00 Best Vegan Protein Sources 20:57 Thoughts on Bryan Johnson 23:01 Negative Effects of Too Many Antioxidants 28:14 Knee Pain Rehab Exercises Get the Biological Age Test Kit + Consultation: https://www.siimland.co/offers/FZVrSHei

Description: Dr. Maya Graham interviews Drs. Gaia Ninatti and Martina Sollini about their recent manuscript entitled: "Pre-operative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas", published online in Neuro-Oncology in September 2022. Full Report

In this week's episode, we'll learn more about the impact of dietary methionine restriction on the progression of AML, discuss transferrin upregulation as a cause of high-altitude-induced hypercoagulability, and learn more about the protective effects of leukemia inhibitory factor against graft-versus-host disease.

Dairy producers face a number of challenges in producing milk profitably, and an understanding of rumen function and ways nutritional strategies can unlock additional pounds of milkfat is one avenue for increasing the opportunity for profitability.At the World Dairy Expo in Madison, Wisconsin, earlier this month, Novus International debuted a new program called Scale Up™; the program is designed to turn production challenges into herd profitability by providing innovative feeding strategies that optimize milk and component yields. Along with increasing beneficial microbiota in the rumen and optimizing rumen function, the program aids in optimizing feed intake and meeting the metabolic needs of lactating cows.In this episode we talk with Ceclia Lopez, Novus' North America ruminant marketing manager, and Dr. Will Seymour, ruminant technical services manager, to learn more about Scale Up.This episode is sponsored by Novus International. You can learn more about the Scale Up program for Dairy by visiting NovusINT.com.

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/gabriellelyon  2:10 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:25 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:00 - AVALONX MAGNESIUM 8: Get Melanie's Broad Spectrum Complex Featuring 8 Forms Of Magnesium, To Support Stress, Muscle Recovery, Cardiovascular Health, GI Motility, Blood Sugar Control, Mood, Sleep, And More! Tested For Purity & Potency. No Toxic Fillers. Glass Bottle.  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Order At avalonx.us, And Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist, And Use The Code MelanieAvalon For 10% On Any Order At avalonx.us And mdlogichealth.com!  5:40 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 6:30 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At melanieavalon.com/cleanbeauty! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:20 - Gabrielle's Background 16:20 - The Effect Of Body Composition And Obesity On Brain Tissue 18:00 - Methionine Restriction  20:00 - Integrated Stress Response 21:20 - Vegan Diets And Health Outcomes 25:10 - Full Restriction Vs Cyclical Restriction  27:10 - The Importance Of Protein Quality 29:30 - Nitrogen Balance  31:00 - RDA 34:00 - The Ratio Of Protein Needed Per Lean Mass 35:40 - Basic Vs Optimal 38:10 - Leucine 40:25 - Protein Absorption And Digestion  41:15 - Multiple Meals Vs One Meal A Day  46:10 - Muscle Maintenance And Muscle Growth 47:30 - Gluconeogenesis 48:50 - Enzymatic Adaptation 49:45 - EMSCUPLT 52:30 - Consuming Excess Protein 53:10 - BUN Creatinine Ratio 54:50 - Filtration Rate 55:00 - LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/melanieavalon To Get A Sample Pack For Only The Price Of Shipping! 57:55 - Are You Burning Fat Or Muscle In A Protein Deficit?  1:00:00 - Protein Sparing Modified Fasts 1:00:30 - Myokines 1:04:40 - Growth Hormone And Fasting 1:05:50 - Protein Intake And Longevity  1:16:15 - Protein Scores On Food Labels 1:20:15 - Plant Based Nutrition

Background Information—Form and Function of B12 Vitamin B12 Form Cyanocobalamin has no known biochemical function. It must be converted to become active. It gets converted for use into hydroxocobalamin, methylcobalamin, or adenosylcobalamin. These three forms are equal in bioavailability.An exception to this is for the use of adenosylcobalamin in infants with a rare inborn error of synthesis.Methylcobalamin and adenosylcobalamin are coenzyme forms of B12.Hydroxocobalamin can be converted into the above two forms. Click here to learn more about the Hedberg Institute Membership. Vitamin B12 Function Vitamin B12 is used for DNA synthesis, homocysteine metabolism, S-adenosylmethionine, red blood cell formation, nervous system and immune system function.Vitamin B 12 is necessary for folate to be metabolized properly into Methionine and Succinyl-CoA. Low levels of B12 and increased levels of folate are associated with higher concentrations of methylmalonic acid (MMA) and total plasma homocysteine (HCY). Vitamin B12 Sources The average American diet contains adequate amounts of vitamins B12, ranging from 5-15 mcg/day. Meat, poultry, fish, eggs, and dairy, constitute the primary food sources. It is not found in most non-animal food sources. Individuals consuming a plant-based diet are at an increased risk of deficiency. Non-meat food sources such as chlorella, spirulina, nori, and fermented soy contain mostly B12 analogues which have no activity in humans. Fifty-one percent of those following a macrobiotic diet were found to be deficient.Vegan Diets 0.3-0.4 mcg/dayLacto-vegetarians 1.4 mcg/day Recommended Dietary Allowances (RDA)Males >14 years: 2.4 mcg/dayFemales >14 years: 2.4 mcg/dayPregnancy: 2.6 mcgLactation: 2.8 mcg Absorption of B12 Pepsin and hydrochloric acid (HCL) are necessary for cleaving B12 from protein in stomach.Individuals with low levels are at a greater risk of deficiency due to decreased break down for absorption.B12 supplements (crystalline B12) do not require HCL or pepsin to bind to intrinsic factor (IF).B12 supplements are absorbed normally in hypochlorhydria.Intrinsic factor (IF) is made in the stomach and necessary for carrying B12 from the stomach to intestines for absorption.Individuals with genetic SNPs impairing intrinsic factor (IF) production are also at a greater risk of deficiency and must rely on B12 injections, bypassing the need for IF.IF becomes fully saturated at 2 mcg of B12.Large doses can be absorbed through passive diffusion which doesn't require IF. This accounts for 1-2% of absorption.1000 mcg/day can overcome loss of IF due to pernicious anemia.Pernicious anemia is an autoimmune disease characterized by the destruction of parietal cells which produce IF. Possible Causes of Vitamin B12 Deficiency Pernicious anemia—Auto antibodies against parietal cells and IFGastric disease or surgeryChronic atrophic gastritis—parietal cell death/autoimmuneUse of gastric acid inhibitors (antacids, histamine receptor 2 antagonists, proton pump inhibitors)Pancreatic disease or pancreatectomyOther intestinal diseases: parasitic infections, bacterial overgrowth, ileal resection, impaired B12/IF absorption.Medications, such as cholestyramine and metformin, that impair B12 absorption or metabolism.Limited/poor food sources/choices that result in general malnutrition. Examples include vegan or vegetarian diet.Chronic alcoholismInherited disorders involved in B12 trafficking and metabolismMiscellaneous: including HIV and nitrous oxide anesthesiaConditions that result in chronic diarrhea or malabsorption states, such as celiac disease and Crohn's disease.Helicobacter pylori infection results in hypochlorhydria. Eradicating H Pylori can improve B12 levels.Long term psyllium supplementation (> 1 year)Genetic factors can affect absorption and transport. Individuals with genetically higher methylmalonic acid levels will require higher-than-normal B12 dose...

Running Performance: Do I Need Creatine? Do I Need Creatine?” is a question we get asked frequently by clients, listeners and also by friends and family!! It is A VERY popular supplement in the world of sport and exercise, in fact it is one of the most popular ergogenic aids used by athletes. BUT….is it necessary? Do you need to take it? To help answer these questions we will: 1. Outline what exactly Creatine is and how it works 2. Look at the benefits and potential drawbacks from taking Creatine Supplements. Is food enough? 3. Focus on key considerations when choosing a Creatine Supplement SHOW NOTES (04:29) Outlining the definition of Creatine and its key role in the body, which is maintaining energy availability   (11:11) Moving on to highlight the therapeutic benefits of this supplement in the ageing population but also in people suffering from certain medical conditions including: Parkinson's Disease and Ischaemic Heart Disease.  (14:39) Highlighting the potential benefits of Creatine supplementation for a runner including: enhanced performance, improved post-exercise recovery, and greater training adaptations (20:18) Focusing on the potential drawbacks of Creatine supplementation for a runner including: water retention, weight gain, and a historic concern about kidney dysfunction  (26:58) Indicating the Creatine requirements from food (i.e.1-2g per day) and the creatine content of certain meats and seafood. For example: herring contains 1.5g of creatine per 100g serving and chicken contains 0.8g of creatine per 100g serving.   (30:11) FEMALE FACTORS Both men and women have shown to benefit from Creatine supplementation, however it is thought that women may not see as much gain in muscle strength or mass during training from supplementation It is thought females may have higher intramuscular creatine concentrations due to the fact that they have lower muscle mass besides men Endogenous Creatine synthesis and transport is hormonally driven therefore its bioavailability differs at different female life-stages. This is because Creatine Kinase (the enzyme required for Creatine synthesis) is influenced by oestrogen and progesterone. CK levels are increased DURING menstruation but decrease during the menstrual cycle, pregnancy, menopause etc. As a result, Creatine supplementation may be particularly important for women during menses, pregnancy, post-partum (after birth) peri/post menopause.  Creatine supplementation is thought to have positive effects on muscle quality and bone health in post menopause females when COMBINED with resistance exercise (36:22) Delving into Creatine supplements and what to consider before embarking on a protocol with a specific focus on which form of supplement to choose and where the creatine has been produced (Germany or China). Some recommended brands include: Motion Nutrition, Bonusan and Thorne Research (42:59) Finally, focusing on dosage and outlining how much Creatine is required per day for someone on a supplement protocol before mentioning ways in which creatine bioavailability may be enhanced. For example; an appropriate stomach acid pH and ingestion alongside carbohydrate and protein rich foods.   (53:26) KEY TAKEAWAYS Creatine is synthesised endogenously from the amino acids: Arginine, Glycine and Methionine. But can also be obtained from the diet in meat and fish The key role of Creatine in the body is to maintain energy availability, hence why it is seen as an effective ergogenic aid for athletes Many runners may be able to maintain Creatine levels via the diet, however for some, supplementation may be required e.g. vegetarian/vegan, older runners, high training load  If thinking about supplementing with Creatine we recommend you work with a qualified and registered NT When choosing a Creatine supplement remember to consider: the form, the brand, bioavailability, and dosage Discontinue any...

Timestamps & Summary 1:25So, Dr. Azahal, I was hoping you would expand a bit for our audience about meeting the nutrient needs of early lactation cows, making sure we have high health, high component yield and successful rebreeding.Dr. Ousama AlZahalThis is really an important topic that we always find ourselves going back to and discussing it with farmers and producers. And it is that cows have different requirements, and these requirements change throughout the whole lactation. And it is important that we ensure that these nutrients are delivered precisely and accurately. That does not only include the amount of feed that we give, but also the concentration of these nutrients and the bioavailability of those nutrients. So hence, it is important to measure dry matter intake, as much as possible, how much we are feeding and also do a frequent assessment of forage analysis and ration balancing.7:36Can you expand a bit more on how negative nutrient balances may play into hampering the performance?Dr. Ousama AlZahalCows cannot eat enough to produce that amount of milk. And it runs into what we refer to very grossly as negative energy balance. But basically, energy itself is not a nutrient. But basically, that trend encompasses several nutrients. So, cows, during that time, are actually false negative in protein. So that will be a negative protein balance, minerals, vitamins, and some of these important molecules like the methyl group.10:56What role does dry matter intake play in negative nutrient balances how does it impact B vitamin synthesis?Dr. Ousama AlZahalThat is a great question. Actually, in new research, new modeling coming out from University of Guelph geneticist's lab, they tried to model the ruminant output of B vitamins, I think they precisely were working on B12, where they've seen that one of the biggest predictors for the output of B vitamins is basically dry matter intake. That goes back to the first point where the cows cannot eat enough during early stages to cover requirements, and they run into negative balances. Now B vitamins are unique and that dietary requirements are insufficient or basically non-existing. And the ruminant animal relies on ruminal synthesis.16:33You talked earlier about the role of methionine, contributing to creating methyl groups but also there is a key point where B12 and folic acid play a role as well, right?Dr. Ousama AlZahalYes, that's true, methionine is an essential amino acid, but there is some misunderstanding that mammals cannot synthesize it. Methionine synthesis basically requires a coupling of two cycles. The first one is the folate cycle which folate is B9, and the second cycle is the methionine cycle. And what really couples the two is B12. Basically, if you have a deficiency in B12 it can lead to a secondary deficiency in folic acid. I think there is quite a significant amount of research from Christiane Girard's lab, just showing how the status of these two B vitamins are basically linked. So, methionine is really interesting. How it is very well connected, and also plays a role in the transformation pathways, which is the production of antioxidants.

On this episode of Fundamental Health, Paul fields a wide variety of questions from attendees at the second annual Animal Based Gathering in Santa Teresa, Costa Rica. Time Stamps: 00:09:42 Podcast begins  00:10:30 How much protein we should eat as we age depending on how much we weigh and how much we move 00:16:00 Does eating excess liver cause copper toxicity or reduce stomach acid? 00:19:00 Should we change our diet even if we think we're thriving? 00:22:30 Can we be allergic to meat? 00:27:10 Is it okay for our LDL and triglycerides to rise when we increase our saturated fat? 00:34:50 Where can we get iodine aside from seafood and kelp? 00:39:00 Thoughts on high levels on deuterium in fruit 00:40:05 Suggestions on keeping tabs on breast cancer 00:43:45 Overcoming food sensitivity and thoughts on food sensitivity tests 00:47:10 Should we take supplements to heal through a lifestyle change? 00:51:16 Thoughts on low baseline sugar levels 00:56:10 Side effects of eggs and thoughts on eggs 00:59:10 Thought on antibiotics 1:04:30 Insulin resistance beginning in the fat cell 1:10:39 Is linoleic acid harmful in all foods? 1:12:30 Anecdote on skin healing  1:16:00 Sugars versus starches? 1:19:00 Methionine glycine balance and thoughts on bone broth 1:22:40 Does liver accumulate heavy metals? Should we be careful about sourcing for liver? 1:24:39 Thoughts on exposure to parasites 1:31:28 How to maintain animal based when on the go 1:33:30 Responding to clinicians that consider animal based disordered eating 1:37:05 Ketosis and mental illness 1:39:40 Speaking on the Animal Based family 1:44:50 Thoughts on remineralizing water and routine testing/labs 1:52:15 Longevity of our ancestors 1:58:42 How should we incorporate fruit and honey for ourselves and our kids? 2:01:40 Animal based eating for women's hormones and pregnancy Sponsors: White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order Sacred Hunting: sacredhunting.com/PAUL, get $250 off your hunt Lets Get Checked: 20% off your order at www.TRYLGC.com/carnivoremd Earth Runners: www.earthrunners.com, use code PAUL for 10% off your order 

____________________________________Have a topic idea or feedback to share? We want to connect with you! Email podcast@standleeforage.comShare our podcast and learn more about our co-hosts at our Beyond the Barn podcast pageSUBSCRIBE to the Beyond the Barn podcast email to be an exclusive insider!Find us on Apple, Spotify or Google Podcasts and SUBSCRIBE, so you never miss an episode.____________________________________Check out the Standlee Barn Bulletin BlogFind more nutritional resources from Dr. Stephen Duren and Dr. Tania Cubitt at https://standleeforage.com/nutrition/nutritional-resourcesConnect with Standlee on Facebook, Instagram, YouTube and TikTok

Part two of my three-part series with methylation expert Dr. Albert Mensah. 1:40 - Is it ever appropriate and/or helpful to combine pharmaceutical approaches with nutraceutical strategies for mental health in the context of methylation? 4:13 - SAMe – a natural SSRI? 7:35 - The SERT gene, SAMe, folate and various other ways one's methyl status impacts serotonin 10:20 - SAM to SAH ratio test: how and why this test can render actionable data http://www.doctorsdata.com/Methyla5on-Pro%EF%AC%81le-plasma (Methylation profile/SAM to SAH ratio test) 17:50 - Ways the SAM to SAH ratio test can become skewed 11:50 - What actually is homocysteine both in the context of methylation and in general? Do homocysteine levels correlate to methyl status? 26:15 - Glycine: have this amino acid's methyl-buffering effects been overstated? 28:50 - Methionine: the concerns over excess methionine. Overstated and out of context? 31:17 - Folate, folic acid and cancer 32:40 - Folate pathway via MTHFR. Is it the main pathway, as most “experts" would have you believe, or is it the backup pathway to re-methylating homocysteine? https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid)Mensahmedical.com Listen to the Accompanying Episode Here: https://player.captivate.fm/episode/4d7f7948-8340-4b0e-b6c6-c7871afcd939 (Methylation: A Primer to My interview with Dr. Albert Mensah)  Email ROTC@rootofthecause.net with your questions, episode requests or feedback.

Creatine is a naturally occurring molecule in your body that helps create cellular energy in exercising muscles, among other benefits. We debunk the common myths and discuss the science you need to know about creatine!  Support your Exercise and Fasting sessions with the new Electrolyte Stix from MYOXCIENCE Nutrition: bit.ly/electrolyte-stix Use code podcast at checkout to save at checkout  Link to research, video and images: http://bit.ly/creatine-science Time Stamps:  00:30 Creatine helps to add phosphorous groups to ADP molecules to remake ATP. ATP is needed to move your muscles. 00:55 The food you eat is broken down into ATP. 01:00 People retained water back in the day when creatine was paired with dextrose (sugar). 03:16 Creatine is a metabolite comprised of 3 amino acids. Arginine, which helps to vasodilate and increase blood flow, glycine, and methionine.  Glycine is part of the glutathione tripeptide. Methionine is a sulfur-containing amino acid. 04:15 You have over 100 grams of creatine in your body. It is found primarily in your muscle tissue because they are energetically demanding. 05:30 Some cuts of beef contain 9.6 mg/gram of dry weight of creatine. Beef is rich in creatine, taurine and carnosine. It also has beta alanine. 06:05 Wheat, soy, potato, and corn contain zero creatine, taurine, beta alanine, and carnosine. If you eat red meat, you are probably getting plenty of creatine. 07:00 ATP is fundamental to cellular processes that underpin skeletal muscle contraction during exercise. Muscle stores little ATP. Metabolic pathways are activated to maintain ATP resynthesis. 07:45 Creatine functions mainly at the muscle level. 09:00 Creatine supplementation can be a multifactorial intervention across the lifespan in women with little to no side effects.  Creatine is not an androgen. It is involved in energy utilization and recycling. 09:35 Creatine supplementation combined with exercise provides musculoskeletal and performance benefits in older adults. 10:10 Creatine paired with electrolytes can improve power output and strength, because it works during the workout. 11:10 Anaerobic power and strength is improved with creatine paired with electrolytes (magnesium, potassium, calcium, and sodium). There was a 10 to 15% benefit in the intervention group in the WWU study.Improvement/progress is motivating. 15:25 As you age, you naturally lose strength and muscle. Supplemental creatine may help counteract some of the strength loss. 15:55 Electrolytes like, magnesium, sodium, and potassium, are transporters used to aid in the absorption and utilization of creatine. 17:40 Creatine uptake is directly impacted by presence of sodium, chloride, and calcium. Creatine uptake is reduced by up to 47%, when there is no calcium or magnesium in extracellular fluid. When concentrations of sodium and chloride are increased, uptake increases, even with no additional creation concentrations. Sodium and chloride are both needed for transport. 19:10 Electrolytes are often taken after a sauna session or before, during or after a workout. Sauna moves a lot of blood in and out of your core.  

Throughout my training and practice as a physician, I have come to one very disappointing conclusion:  Western medicine isn't helping people lead better lives. Now that I've realized this, I've become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you'll join me on this journey. 00:08:33 Podcast begins 00:09:35 What is epidemiology, why is it useful, and when can we use it? 00:12:40 Vegetables + Cardiovascular disease 00:19:40 Interventional studies on vegetables  00:27:22 What is TMAO (Trimethylamine N-oxide)? 00:32:30 Choline and Carnitine 00:37:40 Mainstream literature regarding TMAO 00:41:00 TMAO in fish 00:47:28 What is Neu5gc? 00:56:03 Methionine + Glycine balance, should we worry about excess Methionine from animal foods? Should we supplement with Glycine? 01:11:18 Evolutionary consistency + how much protein should we eat? Sponsors: Heart & Soil: www.heartandsoil.co  Shirttail Creek Farm: shirttailcreekfarm.com, use code CarnivoreMD $10 off order of $100 or more BluBlox: blublox.com, use code CarnivoreMD for 15% off White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order Lets Get Checked: 20% off your order at www.TRYLGC.com/carnivoremd

Today I'm doing a solo episode covering key concepts I discuss in my upcoming interview with one of the leading experts on methylation today, Dr. Albert Mensah. Dr. Mensah was in the game many years prior to the word methylation even becoming part of the functional medicine vernacular. He mentored under Dr. William Walsh, who started doing groundbreaking work on methylation in the mental health sphere decades before MTHFR became a trendy buzz term and years before methylation was at all talked about outside of academic circles. Dr. Mensah is part of this lineage of the great pioneers in the field of methylation research, and as such, you'll see that his knowledge in this area knows no bounds. With that said, I felt that doing a solo episode to provide some background information and a better understanding of some of the advanced concepts we discuss would be of value. Look for my three-part interview series with Dr. Mensah, which will be released in the coming weeks.  2:16 - Selective serotonin re-uptake inhibitor SSRI physiology 101 6:04 - How homocystein is biochemically made 7:30 - Methionine converting to S-adenosyl-L-methione (SAM) 8:03 - SAM converting to SAH 9:02 - The SAM to SAH ratio 9:55 - The methylation misconceptions of folate  12:14 - Selective serotonin reuptake enhancers  13:02 - gene polymorphism (SNP) 101 13:41 - Glycine in the context of methylation https://www.gdx.net/core/supplemental-education-materials/Methylation-Pathway-Handout.pdf (Methylation Pathway Visual Aid) https://www.researchgate.net/figure/Schematic-diagram-showing-mechanism-of-action-of-SSRIs-These-agents-block-the-reuptake_fig1_7730046 (SSRI 101 Visual Aid) Email ROTC@rootofthecause.net with questions or requests for future episodes.

Welcome to the Siim Land Podcast I'm your host Siim Land and today I'm playing you a replay of me being on an Instagram live with Vanessa Ascencao. Vanessa is a nutritional consultant from South Africa. I talked about the benefits of calorie restriction and fasting for longevity on her Instagram vda.nutrition Self Decode is a genetics decoding company. You can get personalized health recommendations based on your DNA and the latest scientific research. They have numerous different DNA reports for different areas of focus like weight loss, longevity, gastrointestinal health, cognition, and even mood. Recently Self Decode came out with their 2.0 software that incorporates artificial intelligence in generating DNA reports. It's the most advanced and comprehensive consumer DNA service in the world. You can get a 10% discount with the code SIIM at get.selfdecode.com/siim Head over to get.selfdecode.com/siim and use the code SIIM for a 10% discount on your personalized DNA reports. Timestamps: 00:55 Introduction 05:20 Calorie Restriction and Longevity 07:00 Recent Age Reversal Study 10:20 Lifespan v s Healthspan 12:30 Do You Need to Be Plant Based 15:02 mTOR, Methionine and Aging 20:35 Protein and Satiety 23:35 What to Do for Longevity 28:30 Women and Resistance Training 34:35 Longevity Supplements 37:50 Siim's One Meal a Day 42:11 How to Eat for Blood Sugar Management And much more Inside Tracker is an at-home biomarker service that you can use to test up to 43 different biomarkers like lipids, liver enzymes, inflammation, sex hormones, and much more. The process is simple – you order the test kit to your home, use the little finger prick device to give your blood, send it back, and you get results to your online dashboard or app. You can get a 25% discount code off all their tests if you head over to siimland.com/insidetracker that's in one word and use the code SIIMLAND at checkout. That's siimland.com/insidetracker and the code is SIIMLAND. Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body.  With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That's an AMAZING value. And I promise that deal is ONLY available on this specific website,  Click Here to Support the Show on Patreon!   Show Notes Vanessa Instagram get.selfdecode.com/siim Code SIIM15 for Essential Amino Acids 15% OFF Join Inside Tracker for 25% Off with Code SIIMLAND Lucas Aoun's Natural Testosterone Optimization Course 10% OFF The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim    

Watch this at YouTube - https://youtu.be/gVR14DMm_D0Hyggee Natural Repair Serum at yesstyle: https://ys.style/tmRXARN7gkbUse Rewards Code NOBSBEAUTY for an additional discount!Hyggee Natural Repair Serum Full Ingredients List:Panax Ginseng Root Extract, Glycerin, Propanediol, 1,2-Hexanediol, Butylene Glycol, Niacinamide, Water, Simethicone, Panthenol, Gelidium Cartilagineum Extract, Laminaria Japonica Extract, Hizikia Fusiforme Extract, Ascophyllum Nodosum Extract, Ascorbic Acid Polypeptide, Lactobacillus Ferment, Glycyrrhiza Glabra (Licorice) Root Extract, Dextrin, Centella Asiatica Extract, Scutellaria Baicalensis Root Extract, Glycine, Polygonum Cuspidatum Root Extract, Serine, Glutamic Acid, Sesamum Indicum (Sesame) Seed Extract, Sophora Flavescens Root Extract, Camellia Sinensis Leaf Extract, Cimicifuga Racemosa Root Extract, Morus Alba Bark Extract, Paeonia Lactiflora Root Extract, Phellinus Linteus Extract, Angelica Gigas Root Extract, Polygonum Multiflorum Root Extract, Aspartic Acid, Leucine, Rosmarinus Officinalis (Rosemary) Leaf Extract, Chamomilla Recutita (Matricaria) Flower Extract, Paeonia Suffruticosa Root Extract, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Valine, Pancratium Maritimum Extract, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine, Cellulose Gum, Ammonium Acryloyldimethyltaurate/VP Copolymer, Sodium Polyacryloyldimethyl Taurate, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Trideceth-10, Theobroma Cacao (Cocoa) Extract, Disodium EDTA, t-Butyl Alcohol, Carbomer, Polyglutamic Acid, PVM/MA Copolymer, Betaine*******Podcast LinksApple - https://b.link/No_BS_Apple_PodcastGoogle - https://b.link/No_BS_Google_PodcastAmazon - https://b.link/No_BS_Amazon_PodcastSpotify - https://b.link/No_BS_Spotify_PodcastStitcher - https://b.link/No_BS_Stitcher_PodcastRSS - https://feeds.redcircle.com/671dd1b2-a989-41d5-94d5-30c014e06149********Sephora - https://fxo.co/1231867/sephoraUlta - https://fxo.co/1231867/ultaAmazon - https://www.amazon.com/shop/nobsbeautyYes Style - https://ys.style/kk2Vjrv798Style Korean - http://www.stylekorean.com/?af_id2=nobsbeautyThese are affiliate links if you purchase anything from one of these stores using this link No BS Beauty will make a small commission on what you buy.********I am proud to offer my very own beauty products at Amazon. We are starting small but hope to grow these offerings. Take a look and if you can pick one or two up, it helps keep this channel truly independent.My Products:No BS Beauty Travel Set - https://amzn.to/2PgPzFZNo BS Beauty Airless Jars - https://bit.ly/2Ev6X6N or https://amzn.to/2RCEq4sNo BS Beauty Color Switcher - https://amzn.to/2RCEAJ6See my own page on Amazon - https://www.amazon.com/shop/nobsbeautywww.noBSbeauty.net*******My Patreon - https://www.patreon.com/noBSbeauty*******PayPal Tip Jar - https://bit.ly/donate_NBSBIf you want to leave a tip ... Thanks! *****

HOUR 2 Arthritis- How to Supplement for Symptom Relief -- Carolyn Dean MD ND  According to RheumatoidArthritis.net, arthritis affects more than 46 million people resulting in disability for 19 million. Arthritis causes more disability than heart disease, diabetes, and back or spine problems. Osteoarthritis (prevalence ~26.9 million), gout (prevalence ~6.1 million), rheumatoid arthritis (prevalence ~1.3 million) in the US. Note: For example, a person who is newly diagnosed with arthritis is an incident case, whereas a person living with arthritis for 10 years is a prevalent case.  Arthritis means inflammation of the joints. It is a very complex and multifaceted disease. A diagnosis of arthritis is made by analyzing X-rays, blood tests, and findings on a clinical examination. The most common finding is wear and tear on the joints and loss of the supporting padding around and between joints.   You can develop joint symptoms due to toxicity from processed foods, sugar, gluten, alcohol, coffee, or food to which you are allergic. These toxins can gather in vulnerable, overworked joints or in areas where you have suffered an injury. The only way to find out if these substances are causing problems is to eliminate them from your diet and see if your joints feel better. An overlooked cause is a subclinical infection that targets the joints. Chinese Medicine addresses this issue and says the Divergent Meridians will direct an internal infection toward the joints to protect the internal organs.  The medical treatment of arthritis merely suppresses pain and inflammation with stronger and stronger prescription medication without understanding that those drugs will cause more inflammation as they build toxicity and drain the body of magnesium and other minerals.   Historically, the first drug used to treat arthritis and hailed as a miracle cure was cortisone. It wasn't long before the horrible side effects of bleeding ulcers, suppression of adrenal gland function and thinning bones turned the miracle into a disaster. Suppression of the adrenal glands begins in as little as 7 days on drugs like prednisone.  A series of NSAIDs (nonsteroidal anti-inflammatory drugs) that claimed to be safer than cortisone were also associated with bleeding ulcers. A newer generation of NSAIDs – Vioxx, Celebrex and Bextra – came under extreme fire in 2005 when Vioxx was shown to cause about 140,000 heart attacks – many fatal. I say that the reason these drugs cause heart side effects is because they deplete the body of magnesium. Ironically, magnesium is the best anti-inflammatory agent you can take for arthritis. Celebrex contains fluoride molecules that can account for its higher rate of heart disease side effects. Fluoride binds magnesium making it unavailable to the body. The resulting MgF2 compound is brittle and deposits in bone, joints, cartilage and tendons creating or increasing symptoms of arthritis. Now we have an absolute epidemic of opioid addiction from the flagrant use of this highly addictive drug. Add to that the addition of the poisonous drug fentanyl to street drug opioids and you have killer combination.  Menopausal women often develop arthritic symptoms. Does cessation of the monthly period, which serves to rid the body of toxins, mean that, instead, the toxins are building up in the joints? The same might be said for iron build-up and high levels of hemoglobin; some researchers believe that women escape heart disease because their blood is not as high in iron and as thick as men's blood. Because women lose blood every month, there is less strain on the heart. Donating blood at the local blood bank can be a sure way to thin out your blood and also stimulate the production of a fresh crop of red blood cells. However, don't forget that proper hydration and a good diet free of sugar and processed foods and drinking plenty of pure water can also keep the blood from sludging and clumping.  What if one of the causes of arthritis is a mineral deficiency but most doctors, who know nothing about recommending minerals to their patients, will never be able to help soothe or relieve arthritis symptoms in a safe, natural way?  Our Completement Formulas help to soothe the symptoms of arthritis in several ways: they can alleviate symptoms caused by mineral and vitamin deficiencies, build cartilage, treat pain and inflammation, and help you avoid the potentially life-threatening side effects of anti-inflammatory medications.  Minerals do their best work inside cells. They pull water in after them to assist in thousands of metabolic processes. If you are deficient in minerals, water has nowhere to go and ends up in tissue spaces causing painful swelling. If you are deficient in minerals you will also have more auto-immune disease, more inflammation, more pain, and more swelling.  My recommendations include:  ReMag is a fully absorbed, bioavailable, non-laxative magnesium. Dosage: ½-1 tsp twice per day. This mineral drives 1,000 enzyme systems in the body. It is a powerful anti-inflammatory and confers the proper resiliency to bones and joints.   ReMyte - is a fully absorbed, bioavailable, multiple mineral that contains 12 complementary minerals many of which will help alleviate the symptoms of osteoarthritis including Magnesium, Boron, Calcium, Zinc, Manganese, Copper  ReAline - sulfur, which promotes the health of ligaments, cartilage, collagen, and tendons can be accessed in ReAline through the two sulfur amino acids, l-methionine, and l-taurine. Methionine and 4 of the B vitamins in ReAline provide methyl groups to the liver's detoxification pathways.  Pico Silver -   As I mentioned earlier, Chinese Medicine defines a type of arthritis that is caused by internal infections being directed at the joints – in an effort to protect the internal organs. Thus Pico Silver can play a major role in helping support the immune system against subclinical infections.  Whole C ReSet is a food-based, organic Vitamin C Complex and one of our Completement Formulas. Vitamin C assists the body in many ways. It is a cofactor in 8 enzyme processes in the body. It assists the growth, maintenance, and repair of skin, blood vessels, bones, and teeth. It is a powerful antioxidant, essential for wound healing, a strong immune system, helps eliminate bruising, strengthens the adrenals, and helps absorb iron.   Wondering if this all works? Consider Gracie's story:  “My 73-year old friend, Grace, who has arthritis, was diagnosed with trigger finger and she was given a cortisone shot but it only lasted 4 weeks. Arthritis gives her excruciating pain and she can't use her hands till the afternoon and her hands are so swollen that she can't even see between her fingers. So I introduced her to ReMag and so far she is sleeping much better. I told her to give it time cause it has been only 3 weeks. Then I told her about ReMyte. She received the ReMyte on Friday and started taking it and called me today, which is 2 days later and told me her pain and swelling subsided quite a bit and for the first time in a long while she can open and close her fingers. I'm so excited for her. The doctors said they could only help her with cortisone shots or surgery and she held off on the surgery because they couldn't guarantee it would work.”  Tonight we'll be talking with Dr. Carolyn Dean about Arthritis: How to Supplement for Symptom Relief along with a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with our callers and hosts alike including the body/mind connection, identifying the ‘conflict' in the ‘conflict basis' of disease and much more!!  About Dr. Carolyn Dean    Dr. Carolyn Dean MD ND has been featured on national media for over 30 years offering practical strategies to improve health, vitality, and well-being the natural way. As a medical doctor, naturopath, certified clinical nutritionist and master of many modalities including acupuncture and homeopathy, Dr. Carolyn Dean MD ND has authored over 33 books and 100 publications including The Magnesium Miracle, 3rd Edition, Hormone Balance, Future Health Now Encyclopedia and Heart Health. Please note that the information and opinions expressed on these broadcasts are not designed to constitute advice or recommendations as to any disease, ailment, or physical condition. You should not act or rely upon any information contained in these broadcasts without seeking the advice of your personal physician. If you have any questions about the information or opinions expressed during these broadcasts, please contact your doctor.  Video Version: https://youtu.be/VD7t441QGC0 Disclosure: Dr. Dean does have a financial interest in the sale of all the Completement Formulas.  Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand  Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.com We will be glad to respond to your email  Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com   Chatline on Station: http://bit.ly/Dreamvisions7Radio_Network 

HOUR 1 Arthritis- How to Supplement for Symptom Relief -- Carolyn Dean MD ND  According to RheumatoidArthritis.net, arthritis affects more than 46 million people resulting in disability for 19 million. Arthritis causes more disability than heart disease, diabetes, and back or spine problems. Osteoarthritis (prevalence ~26.9 million), gout (prevalence ~6.1 million), rheumatoid arthritis (prevalence ~1.3 million) in the US. Note: For example, a person who is newly diagnosed with arthritis is an incident case, whereas a person living with arthritis for 10 years is a prevalent case.  Arthritis means inflammation of the joints. It is a very complex and multifaceted disease. A diagnosis of arthritis is made by analyzing X-rays, blood tests, and findings on a clinical examination. The most common finding is wear and tear on the joints and loss of the supporting padding around and between joints.   You can develop joint symptoms due to toxicity from processed foods, sugar, gluten, alcohol, coffee, or food to which you are allergic. These toxins can gather in vulnerable, overworked joints or in areas where you have suffered an injury. The only way to find out if these substances are causing problems is to eliminate them from your diet and see if your joints feel better. An overlooked cause is a subclinical infection that targets the joints. Chinese Medicine addresses this issue and says the Divergent Meridians will direct an internal infection toward the joints to protect the internal organs.  The medical treatment of arthritis merely suppresses pain and inflammation with stronger and stronger prescription medication without understanding that those drugs will cause more inflammation as they build toxicity and drain the body of magnesium and other minerals.   Historically, the first drug used to treat arthritis and hailed as a miracle cure was cortisone. It wasn't long before the horrible side effects of bleeding ulcers, suppression of adrenal gland function and thinning bones turned the miracle into a disaster. Suppression of the adrenal glands begins in as little as 7 days on drugs like prednisone.  A series of NSAIDs (nonsteroidal anti-inflammatory drugs) that claimed to be safer than cortisone were also associated with bleeding ulcers. A newer generation of NSAIDs – Vioxx, Celebrex and Bextra – came under extreme fire in 2005 when Vioxx was shown to cause about 140,000 heart attacks – many fatal. I say that the reason these drugs cause heart side effects is because they deplete the body of magnesium. Ironically, magnesium is the best anti-inflammatory agent you can take for arthritis. Celebrex contains fluoride molecules that can account for its higher rate of heart disease side effects. Fluoride binds magnesium making it unavailable to the body. The resulting MgF2 compound is brittle and deposits in bone, joints, cartilage and tendons creating or increasing symptoms of arthritis. Now we have an absolute epidemic of opioid addiction from the flagrant use of this highly addictive drug. Add to that the addition of the poisonous drug fentanyl to street drug opioids and you have killer combination.  Menopausal women often develop arthritic symptoms. Does cessation of the monthly period, which serves to rid the body of toxins, mean that, instead, the toxins are building up in the joints? The same might be said for iron build-up and high levels of hemoglobin; some researchers believe that women escape heart disease because their blood is not as high in iron and as thick as men's blood. Because women lose blood every month, there is less strain on the heart. Donating blood at the local blood bank can be a sure way to thin out your blood and also stimulate the production of a fresh crop of red blood cells. However, don't forget that proper hydration and a good diet free of sugar and processed foods and drinking plenty of pure water can also keep the blood from sludging and clumping.  What if one of the causes of arthritis is a mineral deficiency but most doctors, who know nothing about recommending minerals to their patients, will never be able to help soothe or relieve arthritis symptoms in a safe, natural way?  Our Completement Formulas help to soothe the symptoms of arthritis in several ways: they can alleviate symptoms caused by mineral and vitamin deficiencies, build cartilage, treat pain and inflammation, and help you avoid the potentially life-threatening side effects of anti-inflammatory medications.  Minerals do their best work inside cells. They pull water in after them to assist in thousands of metabolic processes. If you are deficient in minerals, water has nowhere to go and ends up in tissue spaces causing painful swelling. If you are deficient in minerals you will also have more auto-immune disease, more inflammation, more pain, and more swelling.  My recommendations include:  ReMag is a fully absorbed, bioavailable, non-laxative magnesium. Dosage: ½-1 tsp twice per day. This mineral drives 1,000 enzyme systems in the body. It is a powerful anti-inflammatory and confers the proper resiliency to bones and joints.   ReMyte - is a fully absorbed, bioavailable, multiple mineral that contains 12 complementary minerals many of which will help alleviate the symptoms of osteoarthritis including Magnesium, Boron, Calcium, Zinc, Manganese, Copper  ReAline - sulfur, which promotes the health of ligaments, cartilage, collagen, and tendons can be accessed in ReAline through the two sulfur amino acids, l-methionine, and l-taurine. Methionine and 4 of the B vitamins in ReAline provide methyl groups to the liver's detoxification pathways.  Pico Silver -   As I mentioned earlier, Chinese Medicine defines a type of arthritis that is caused by internal infections being directed at the joints – in an effort to protect the internal organs. Thus Pico Silver can play a major role in helping support the immune system against subclinical infections.  Whole C ReSet is a food-based, organic Vitamin C Complex and one of our Completement Formulas. Vitamin C assists the body in many ways. It is a cofactor in 8 enzyme processes in the body. It assists the growth, maintenance, and repair of skin, blood vessels, bones, and teeth. It is a powerful antioxidant, essential for wound healing, a strong immune system, helps eliminate bruising, strengthens the adrenals, and helps absorb iron.   Wondering if this all works? Consider Gracie's story:  “My 73-year old friend, Grace, who has arthritis, was diagnosed with trigger finger and she was given a cortisone shot but it only lasted 4 weeks. Arthritis gives her excruciating pain and she can't use her hands till the afternoon and her hands are so swollen that she can't even see between her fingers. So I introduced her to ReMag and so far she is sleeping much better. I told her to give it time cause it has been only 3 weeks. Then I told her about ReMyte. She received the ReMyte on Friday and started taking it and called me today, which is 2 days later and told me her pain and swelling subsided quite a bit and for the first time in a long while she can open and close her fingers. I'm so excited for her. The doctors said they could only help her with cortisone shots or surgery and she held off on the surgery because they couldn't guarantee it would work.”  Tonight we'll be talking with Dr. Carolyn Dean about Arthritis: How to Supplement for Symptom Relief along with a wide range of health topics and safe solutions. You will love hearing the beneficial interactions with our callers and hosts alike including the body/mind connection, identifying the ‘conflict' in the ‘conflict basis' of disease and much more!!  About Dr. Carolyn Dean    Dr. Carolyn Dean MD ND has been featured on national media for over 30 years offering practical strategies to improve health, vitality, and well-being the natural way. As a medical doctor, naturopath, certified clinical nutritionist and master of many modalities including acupuncture and homeopathy, Dr. Carolyn Dean MD ND has authored over 33 books and 100 publications including The Magnesium Miracle, 3rd Edition, Hormone Balance, Future Health Now Encyclopedia and Heart Health. Please note that the information and opinions expressed on these broadcasts are not designed to constitute advice or recommendations as to any disease, ailment, or physical condition. You should not act or rely upon any information contained in these broadcasts without seeking the advice of your personal physician. If you have any questions about the information or opinions expressed during these broadcasts, please contact your doctor.  Video Version: https://youtu.be/VD7t441QGC0 Disclosure: Dr. Dean does have a financial interest in the sale of all the Completement Formulas.  Call in and Chat with Dr. Dean during Live Show with Video Stream: Call 646-558-8656   ID: 8836953587 press #.  To Ask a Question press *9 to raise your hand  Dr. Dean takes questions via email. Please write questions@drcarolyndeanlive.com We will be glad to respond to your email  Learn more about Dr. Carolyn here: https://drcarolyndeanlive.com   Chatline on Station: http://bit.ly/Dreamvisions7Radio_Network 

This podcast describes some of the key features of the essential amino acid methionine, as well as, the role of vitamin B12 and folic acid in its resynthesis from homocysteine. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG --- Send in a voice message: https://anchor.fm/a-j-ghalayini/message

Hello everyone, welcome to the CattleCalPodcast! This is the sixth podcast of the “Feedlot Research” series. In this episode, we talked about the article entitled: "Influence of supplementation of growing diets enriched with rumen-protected methionine and lysine on feedlot performance and characteristics of digestion in Holstein steer calves". Written by Montaño et al. in 2019. If you want to receive a pdf copy of the articles mentioned in this episode, please send an email to cattlecalucd@gmail.com with the title “Feedlot Research Request”, and we will send it to you. Enjoy the call. Follow CattleCal on Instagram: https://www.instagram.com/cattlecal/ Subscribe to our monthly newsletter: http://ceimperial.ucanr.edu/news_359/CattleCal_483/ Send an email to cattlecalucd@gmail.com with questions and feedback. Thank you very much! And remember: "It is always a great time for a CattleCal".

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: If my methionine is high, do I need to worry about betaine? If your methionine is on the higher side then it's probably the case that you don't really have an issue with recycling homocysteine to methionine. TMG's role in methylation is to support the recycling of homocysteine methionine. So if your methionine levels are on the high side of normal then you probably don't need TMG, but I'm also not sure what you mean by methylation issues. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Hello everyone, welcome to the CattleCalPodcast! This is the fifth podcast of the “Feedlot Research” series. In this episode, we talked about the article entitled: "Influence of methionine supplementation of growing diets enriched with lysine on feedlot performance and characteristics of digestion in Holstein steer calves". Written by Torrentera et al. in 2016. If you want to receive a pdf copy of the articles mentioned in this episode, please send an email to cattlecalucd@gmail.com with the title “Feedlot Research Request”, and we will send it to you. Enjoy the call. Follow CattleCal on Instagram: https://www.instagram.com/cattlecal/ Subscribe to our monthly newsletter: http://ceimperial.ucanr.edu/news_359/CattleCal_483/ Send an email to cattlecalucd@gmail.com with questions and feedback. Thank you very much! And remember: "It is always a great time for a CattleCal".

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: For how long does methionine from a meal support methylation? What I can say much more easily is that methionine is going to effectively run out as the fasting state emerges. Methionine has many fates, right? And so if it all goes into the methylation pool, it's going to be quickly either used for methylation or broken down in the CBS pathway. You are not going to save methionine for the fasting state. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: Low cystine & sulfate, mid-range methionine, high homocysteine: what to do? My default position on this would be, you probably don't have a problem recycling homocysteine to methionine. And that might explain why, I'm assuming this is in the fasting state, your homocysteine is only slightly elevated. Now, if you mean by slightly elevated, if you mean slightly elevated outside of the lab's reference range, then that's very elevated. And so I would look at that a little bit differently, but especially when paired with the low cystine and sulfate levels, it sounds like you have a low rate of the transsulfuration pathway or the CBS enzyme, which is the first step in that pathway, which takes homocysteine down to cysteine, which then can be metabolized to sulfate. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Join Shads and returning special guest Marc of Oh No, Anime! and returning returning special guest Alexander Smit as they cover the final three episodes of Dynazenon and dive head first into topics like Godzilla references, Kai Ikarashi's contributions to Episode 10, the power of friendship, Gauma's fate, Koyomi's backstory, the power of memories and more! Musical Credits: METHIONINE - 13 Sentinels Aegis Rim OST by Basiscape & Hitoshi Sakimoto Yume no Hero - Denkou Choujin Gridman OST by Akira Ōtsu, Kisaburo Suzuki, Masaki Iwamoto and Norio Sakai CALICOMP 1.1 Shutdown - VA-11 HALL-A OST by Michael Kelly Marc's Twitter: @vermillionair3 Oh no, Anime! Twitter: @ohnoanime Marc's YouTube: Oh No, Anime! on YouTube! Alexander's Twitter: @BioD42 Alexander's Blog: All The Media Matters --- Send in a voice message: https://anchor.fm/waruideshou/message

Join Shads and returning special guest Marc of Oh No, Anime! as they discuss the follow up to SSSS.Gridman and talk about the arrival of GRIDKNIGHT on the scene and what it means for the show, how to handle team ups across shared entries in a franchise, Koyomi's flaws, the power of friendship, sweet bowling victories and more! Support Warui Deshou: https://www.patreon.com/waruideshou Musical Credits: METHIONINE - 13 Sentinels Aegis Rim OST by Basiscape & Hitoshi Sakimoto Yume no Hero - Denkou Choujin Gridman OST by Akira Ōtsu, Kisaburo Suzuki, Masaki Iwamoto and Norio Sakai CALICOMP 1.1 Shutdown - VA-11 HALL-A OST by Michael Kelly Marc's Twitter: @vermillionair3 Oh no, Anime! Twitter: @ohnoanime Marc's YouTube: Oh No, Anime! on YouTube! --- Send in a voice message: https://anchor.fm/waruideshou/message

Join Doc, Shads and returning special guest Marc of Oh No, Anime! as they discuss the follow up to SSSS.Gridman and talk about the show's wonderfully strong and consistent comedic streak, the repeated visual cues and motifs from SSSS.Gridman, water park hijinks, churros, what the agenda of the Kaiju Eugenicists might be, piecing together a narrative of a person through second hand accounts, and more! Support Warui Deshou: https://www.patreon.com/waruideshou Musical Credits: METHIONINE - 13 Sentinels Aegis Rim OST by Basiscape & Hitoshi Sakimoto Yume no Hero - Denkou Choujin Gridman OST by Akira Ōtsu, Kisaburo Suzuki, Masaki Iwamoto and Norio Sakai CALICOMP 1.1 Shutdown - VA-11 HALL-A OST by Michael Kelly Marc's Twitter: @vermillionair3 Oh no, Anime! Twitter: @ohnoanime Marc's YouTube: Oh No, Anime! on YouTube! --- Send in a voice message: https://anchor.fm/waruideshou/message

Get ready to engage Big Kid Mode ladies, gentlemen and enbies as we're back for the Spring 2021 anime season to talk shop about the second entry in Studio Trigger and Tsubaraya's Gridman anime universe, SSSS.Dynazenon! DYNAZENONNNNNNN Sorry, the chorus is obligatory. I don't make the rules. Join Doc, Shads and returning special guest Marc of Oh No, Anime! as they discuss the follow up to SSSS.Gridman and talk about the show's themes of the ties that bind, the deep lore of Gridman and how it plays into Gauma's origins, the big kid effect, the depiction of city wide destruction, Minami's character, the Kaiju Eugenicists- I mean, Race Realists and more! Support Warui Deshou: https://www.patreon.com/waruideshou Musical Credits: METHIONINE - 13 Sentinels Aegis Rim OST by Basiscape & Hitoshi Sakimoto Yume no Hero - Denkou Choujin Gridman OST by Akira Ōtsu, Kisaburo Suzuki, Masaki Iwamoto and Norio Sakai CALICOMP 1.1 Shutdown - VA-11 HALL-A OST by Michael Kelly Marc's Twitter: @vermillionair3 Oh no, Anime! Twitter: @ohnoanime Marc's YouTube: Oh No, Anime! on YouTube! --- Send in a voice message: https://anchor.fm/waruideshou/message

It's really easy to get into the mindset that methionine is "good" and homocysteine is "bad" but the truth is so much more interesting than that! Let's talk about: The nutrients you are probably getting way too much of if you live in the West. How "boosting your protein" might be a failed strategy. The weird link between methionine and Covid-19 Why MTHFR folks have to be extra careful about their protein intake. Don't miss the detailed show notes here with all the protein requirements and if you're as excited about Genetic Rockstars as I am, click to join. --- Send in a voice message: https://anchor.fm/tohealthwiththat/message

Full show notes @ https://thesternmethod.com/mark-simon/ Mark Simon, CN, CHCC, CPBN Mark Simon established the Nutritional Oncology Research Institute (NORI) in 2011 as an organization focused on advancing cancer care through optimization of diet and application of targeted nutraceuticals. Mark Simon's background and interests are in diverse fields including clinical nutrition, biomedical engineering, plant-based nutrition, naturopathic medicine and neuroscience. ***Resources Mentioned*** Nutritional Oncology Research Institute  Cancer Schmancer Can Dietary Methionine Restriction Increase the Effectiveness of Chemotherapy in Treatment of Advanced Cancer? NORI PROTOCOL - methionine video by Dr. Mark Gregor Fruit, The Lymphatic System & Cancer: Dr. Robert Morse Book: Fit for Life by Harvey Diamond Scientific papers on Methionine, Sodium Selenite, Vit E, Melatonin AntibioticWatchdog Nutritional Oncology Research Institute - Cbd, Hemp CBD, Hemp NORI CBD - Cbd, Cbd, Alternative Health Products, Cbd Oil Nutritional Oncology Research Institute - Home Pure Organic Super-Greens Powder Algae Omega-3 Oil, 400 mg DHA per ml  https://norinutraceuticals.com/shop/ols/products/selenium Zinc Chelate, 15 mg, 90 tablets  Vitamin D3, 2,000 IU, 360 tablets Iodine, 1.8 mg/drop Sublingual Vitamin B12, 500 micrograms Methylcobalamin, 120 Tablets 1 oz. Organic Broccoli and Radish Sprout Powder (High Sulforaphane Content) Vitamin E Delta, Gamma Tocotrienols, Annatto Derived (DeltaGold), 60 ml, 21,000 mg  Melatonin, 50 mg, 360 Tablets  Glucosamine HCl Powder, 8 oz., 227 grams Sodium Selenite, 2 mg, 180 Slow Release Tablets   *Use code STERN at checkout to receive a discount     The Stern Method Website - What We Use: Top Anti-Cancer Supplements Essential Oils We Use Including Our Targeted Blends Cancer Fighting Tools for Detox and Cancer Fighting My Kid Cures Cancer Anti-Cancer, Non-Toxic, Healthy Lifestyle Products We Use           *** In This Episode: Our guest today, Mark Simon, talks about how eating a low methionine diet can lead to better health and cancer cell death (apoptosis).  In this episode, Mark and Ryan discuss the benefits of a plant-based diet which is high in fruits and berries, moderate in vegetables and void of animal products. Through his work at the Nutritional Oncology Research Institute, Mark has developed the NORI protocol, based on the two core concepts of restricting methionine intake and using high doses of sodium selenite (selenium salts) and other targeted nutraceuticals to reduce tumor cell growth. In-vivo studies and clinical experience affirm the effectiveness of this type of diet. The concept of using pro-oxidants versus anti-oxidants is discussed as is the mechanism of sodium selenite and the relationship between methionine and cancer. This conversation may challenge the way you currently view your nutritional protocol. We encourage you to keep an open mind. Be prepared to stretch your current point of view and perhaps gain some new insight and ideas. Please enjoy this next installment of the Anti-cancer Revolution! Be sure to let us know what you think below.   0:41 Fruit or no fruit – That is the million dollar question Mark promotes a methionine restricted diet - high fruit, moderate vegetables, no animal products Utilizes Vitamin E, tocotrienol, selenium, iodine 2:30 Overview of the NORI protocol Based on two core ideas -  methionine restricted diet &  high dose selenium (sodium selenite) Mark started the diet based on personal experience after his wife was diagnosed with stage 3 breast cancer Diet plays a huge role as a tool in cancer prevention Sodium selenite is a form of selenium studied for over 40 years Is a selective chemo-therapeutic agent Can kill cancer cells without causing harm to other cells High bio-availability Can be administered intravenously or orally 6:00 Relationship between methionine and cancer cells Mark discover the work of Dr. Daniel E. Epner, MD - clinical studies using methionine restricted diet Video by Dr. Mark Gregor on Mark’s website describing methionine and what it does Methionine is an amino acid If methionine is restricted, cancer cells die Could potentially work as stand-alone therapy 8:30 How do you reduce methionine in the body and what is the end goal? Through the diet methionine levels can be brought quite low All whole foods contain some level of methionine Fruits contain the least amount of methionine Grains, nuts, beans, seeds, animal products contain the most Best to cycle methionine levels on and off In the future hope is to be able to bring methionine levels to zero 10:05 What do cancer cells do with methionine? Cancer cells use methionine as a building block  Methionine is not needed for normal cell growth- not an essential amino acid MTOR pathway is stimulated less with methionine restriction Methionine restriction makes cancer cells more sensitive to treatment NORI diet is a platform to slow down tumor growth and make cancer more sensitive to treatment 13:50 What are your thoughts on eating fruit? Fruit is not the same thing as table sugar Most fruits are low glycemic Fruitarian diet does not cause high blood sugar 80-10-10 diet (80% fruit, 10% protein, 10% fat) Sugar does not encourage tumor growth, insulin does Ketogenic diet doesn’t work long term because glutamine is not cut out of diet 18:00 NORI diet restricts other cancer-dependent amino acids besides methionine Glutamine Phenylalanine Isoleucine Tryptophan Asparagine 18:30 NORI diet is an alkaline diet Alkaline diet helps neutralize acidity around tumors Anti-inflammatory Anti-angiogenesis Dr. Robert Morse recommends a similar program 20:05 Where do you stand on juicing fruit? Is there a difference between eating fruit and vegetables with or without fiber? A little bit of freshly squeezed citrus juice is fine Bottled juices - no Believes juicing is counter-productive More antioxidants flooding the system makes it harder to fight cancer Hasn’t seen data showing success with juicing and stage 4 cancer Plant based diet is a good idea Cancers are crazier today than years ago Gerson’s original diet involved orange juice and lower protein (lower methionine) Juicing probably doesn’t get phytochemicals up to appropriate levels 23:45 Can you elaborate on antioxidants and cancer? Study with animals on low-antioxidant diet slowed tumor progression Normal cells operate on a low level of oxidative stress Cancer cells operate at a high level of oxidative stress because of altered metabolism Adding oxidative stress will push cancer cells over the edge Cancer cells are dependent on anti-oxidant systems like: Glutathione Thioredoxin Catalyse Superoxide dismutase If you block glutathione synthesis, cancer cells die off Putting anti-oxidants into the system aids cancer survival such as: Vitamin E (alpha-tocopherol form) Vitamin C NAC (N-Acetyl Cysteine) Vitamin A NORI program is careful not to incorporate juicing or other antioxidant supplements NORI program utilizes pro-oxidants which increase oxidative stress Sodium selenite Generates hydrogen peroxide Generates ROS (reactive oxygen species) Triggers cell apoptosis 28:30 What are your thoughts on using antioxidants to increase chemotherapy and drug success? Oncologists tell patients no antioxidant supplements because they know they will interfere with treatment Antioxidants protect cancer cells Mark hasn’t seen any research showing antioxidants make chemo work better Research shows pro-oxidant therapy helps chemo work better  Sodium selenite Ozone therapy Sulforaphane (need 10-20 grams or more) - not too efficient 32:30 Can you give us a breakdown of the different levels of methionine within food groups? Foods highest in methionine: Chicken and fish Next: other animal products- beef, dairy, eggs Mark has been vegan for 30 years (supplements with B12 occasionally) Caution: B-12 can be used by cancer cells for protein synthesis Soy, sesame seeds, and brazil nuts are high in methionine Lowest: apple, most fruits  Dark green veggies are fairly high Hard part is getting enough calories on a low methionine diet Potatoes and rice work to bring up weight 38:40 Cycling on and off low-methionine foods Encourage fruit-only breakfast (easily digested, full of enzymes, fiber, water, cleansing, detoxifying, extends a fast) Book: Harvey Diamond, Fit for Life  Food combining Methionine restriction is anti-aging Ketosis is not necessarily a healthy state -  not natural/normal  Not a proponent of fasting for cancer patients - too stressful Recommends a fruit-only diet instead of fasting Super-charge your system by eating raw, high-energy, plant-based foods 44:30 What is the distinction between nutraceuticals and supplements? Use supplements to fill in gaps Recommends supplementing with iodine, selenium, vitamin D, zinc, B12 Nutraceuticals can be used to lower inflammation Sodium selenite is used as an anticancer nutraceutical  Vitamin E delta tocotrienol- high dose kills cancer cells Glucosamine alters cancer cells High-dose zinc is effective in killing cancer cells Melatonin effective in fighting cancer (300 mg)  Curcumin - plant derived medicine - not very bioavailable Medicines work because of toxic effects on system/system modulation 50:20 How did selenium and tocotrienols stand out to you?   High index of therapeutic value High bioavailability Water solubility ADME Absorption, Distribution, Metabolism and Excretion - nutraceuticals are analyzed according to this standard Sodium selenite has reached animal and human clinical studies (in-vivo) Methionine restriction is being used in ongoing human clinical studies   55:20 What is the mechanism of action of sodium selenite?   Selective pro-oxidant Study which shows it inhibits glutamine metabolism Natural high uptake into tumor tissue Radioactive sodium selenite (SE-75) was used in the 1960s to highlight cancer cells on imaging tests Relatively small amount of sodium selenite (10-20 mg) is typically needed at therapeutic threshold levels 9 hour half-life Cells need to be exposed 24 to 72 hours or more - the longer the better Lower doses can be sustained for longer periods of time .3 mg/kg of body weight is dosage for IV sodium selenite IVs are used for pulsing in addition to oral dosage IVs can become cost-prohibitive   1:01:30  Hazards of buying sodium selenite online   Can be risky - might be over a toxic dose or too weak Mark sells some on his website Might not be pharmaceutical dose Signs of overdose Hair loss Brittle nails Use under supervision   1:03:00  Is this an extract of selenium versus a whole compound?    Sodium selenite is a mineral salt - inorganic form of selenium- trace mineral Chemical formula Na 2 Se0 3 Body needs it all the time Organic forms vary in the level of anti-cancer activity 100% water soluble- easily crosses blood-brain barrier Vitamin E used is extracted from annatto seed - delta tocotrienol Pro-oxidant  Looks and behaves like unsaturated fatty acid Initiates lipid peroxidase chain reaction Ends up in mitochondrial membrane Interacts with and generates more ROS Triggers cancer cells to die - apoptosis Mitochondria are dysfunctional in cancer cells Breaks the positive feedback loop of the mitochondria so cells can die   1:09:39  You mentioned DHA. Where do you get yours?   Mark uses an algae oil Studies show DHA can be used therapeutically in cancer (6g/day) DHA will become incorporated into the cancer cell membranes and will undergo lipid peroxidase reactions Algae oil is unstable and oxidizes easily  Antioxidants are added to maintain stability and this can be enough to interfere with NORI protocol   1:11:20  Budwig diet - similarities and differences   Fruit, berries, no animal products Cottage cheese and flax oil mixture Flax contains ALA, a polyunsaturated fat Studies show ALA can trigger cancer cells to die Flaxseed oil must be freshly pressed (15-30g) Cottage cheese/quark works as an emulsifying agent to break up the oil for bioavailability Theoretically based on the science, it should work Not in favor of it right now because there are better methods Tocotrienol does the same thing only with more efficiency   1:15:30 Lithium Chloride   Still under study Has a favorable effect on cancer pathways Used as treatment booster Studies with lithium chloride used in conjunction with 5FU in animals   1:17:07 NORI protocol is currently using 6 agents   3 core agents make up the cytotoxic cocktail Vit E tocotrienol (1200mg), sodium selenite, Vit K3 3 other agents working around the cocktail Glucosamine (8g), zinc citrate (150mg), melatonin (300mg) Used in conjunction with methionine-restricted diet Protocol is continually evolving based on clinical experience Simple, low-cost   1:19:10 Where can we find you?   https://antibioticwatchdog.com/ Website covering relationship between antibiotics and cancer Free ebook https://norinutraceuticals.com/ (store)  https://noricbd.com/ https://nutritionaloncology.net/ Info on program and protocol Mailing list CBD products and nutraceuticals - Use code STERN Free consultations (30-60 min)   1:22:00 Closing remarks   Please check out the podcast links and the links on our website (“What We Use” section). Your patronage is greatly appreciated and helps keep the lights on.  For more info about fruit in the diet and to view our most popular video, see Ryan’s podcast with Dr. Robert Morse. Link Below. Use your intuition and try different options if a current protocol is not working. There are many paths to wellness. Future podcast idea: feature two experts on opposite sides of a topic and let them discuss the pros and cons of each Please send your ideas for future speakers to info@anticancerrevolution.com As always, if you are going through cancer….just keep going!     Related Podcasts Fruit, The Lymphatic System & Cancer: Dr. Robert Morse     If you have a question or comment about this episode let us know below!!

Best Most Absorbable Forms of Minerals– Dr. Jason Jones Elizabeth City NC, Chiropractor Minerals play key roles in various bodily functions, including muscle contraction, bone health, fluid balance, growth, and many other processes.   However, some can be difficult for your body to absorb, and that’s why minerals are often in the chelated forms for increased absorption. Chelated minerals are bound to compounds like organic or amino acids, and they have gained much interest recently. The chelating agents or compounds helps to boost your body’s uptake of the mineral involved. Types of Absorbable or Chelated Minerals You can get most minerals in the chelated forms, and some of the most common minerals include: Zinc Calcium Copper Magnesium Iron Chromium Cobalt Potassium Chelated Minerals Using Amino Acids Some amino acids commonly used to make mineral chelates include: Methionine: used for making zinc methionine, copper methionine, and many more Aspartic acid: used for making magnesium aspartate, zinc aspartate, and more Monomethionine: used for making zinc monomethionine Glycine: used for making magnesium glycinate Lysine: used for making calcium lysinate Chelated Minerals Using Organic Acids Some organic acids commonly used for making mineral chelates include: Citric acid: used for making magnesium citrate, chromium citrate, and more Acetic acid: used for making calcium acetate, zinc acetate, and more Gluconic acid: used for making zinc gluconate, iron gluconate, and more Orotic acid: used for making lithium orotate, magnesium orotate, and more Picolinic acid: used for making magnesium picolinate, chromium picolinate, and more. Fumaric acid: used for making iron (ferrous) fumarate Absorption of Chelated Minerals Chelated minerals have been shown by several studies to have better absorption than non-chelated ones. One study in 15 adults shows that chelated zinc (zinc gluconate and zinc citrate) was absorbed 11% more effectively than non-chelated options like zinc oxide. Another study in 30 adults found that magnesium glycerophosphate (which is chelated) raised the level of magnesium in the blood far more significantly than magnesium oxide (which is non-chelated). Some other studies suggest that taking chelated minerals help to reduce the total amount you need to consume to attain healthy blood levels. This supports people who are at risk of excess mineral intake. Should You Use Chelated Minerals? Sometimes, taking minerals in the chelated forms is more suitable. For example, older people tend to produce less stomach acid, which affects mineral absorption. But chelated minerals don’t require much stomach acid to be efficiently absorbed. So chelated minerals may be more suitable as you grow older. Also, if you’re the type that experience stomach pain after taking supplements, chelated minerals may benefit you as they’re less dependent on stomach acid for digestion. You can consult Dr. Jason Jones t our chiropractic office in Elizabeth City, NC to get the best advice before trying out any chelated minerals.    

In this episode, Ben Azadi shares his 40-day carnivore experience. Ben reviews his complete lab work from day 1, and compares it to day 40. Get your grass fed beef, wild caught fish, and healthy carnivore protein at U.S. Wellness Meats. Click here to visit U.S. Wellness Meats website. Use the coupon code ketokamp for 15% off your entire order. Become a Keto Kamp Academy member today at 50% off. Visit http://www.kkaspecial.com Use the coupon code keto50 to be locked in at this rate. // E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. http://www.Kettleandfire.com/ketokamp and use KETOKAMP at checkout to save 15% on your entire order. ☕️ Purity Coffee: http//:www.ketokampcoffee.com, use ketokamp at checkout for 10% off *Some Links Are Affiliates* // C A R N I V O R E  N U G G E T S Methionine glycine balance. It’s important to include collagen via organ meats, supplements, and bone broth.  Methionine is commonly found in muscle meat. Glycine is found in connective tissue and organ meat.  Methionine is a carrier of methyl groups, when you have too much methionine  it uses up your bodies glycine to buffer up the methyl groups. This will mess up your biochemistry. Glycine balances methionine and helps the amino acid ratio. If you are glycine deficit it will be difficult to make collagen and glutathione (meaning you won’t feel as good) Key Supplements For Carnivore: Boron Paleo Valley Bone Broth Powder Paleo Valley Organ Meat Complex Another tip for not feeling well is to increase your fat to protein ratio.  The organ meats are key, it is nature’s multivitamin. Especially liver! B vitamins Methionine Riboflavin Selenium Choline Vitamin A in retinol form Vitamin C A popular objection to eating liver is the belief that the liver is a storage organ for toxins in the body. While it is true that one of the liver’s role is to neutralize toxins (such as drugs, chemical agents and poisons), it does not store these toxins. Toxins the body cannot eliminate are likely to accumulate in the body’s fatty tissues and nervous systems. On the other hand, the liver is a is a storage organ for many important nutrients (vitamins A, D, E, K, B12 and folic acid, and minerals such as copper and iron). These nutrients provide the body with some of the tools it needs to get rid of toxins. Ben Carnivore Lab Work Notes: BUN went up moving more protein through my kidneys  Blood Urea Nitrogen and Creatinine these are byproducts of different functions in the body BUN/CREATININE ratio went up Albumin protein went up   AST ALT went down    Ferritin went up but this can be an issue if there’s oxidized fats in the body. It’s important to look at other oxidative stress markers. C-Reactive protein went down more than 50% (inflammation in the blood vessels) Homocysteine dropped vascular and brain inflammation  Cholesterol and LDL’s went up. The body is clearing the system with cholesterols, cholesterol is a band aid, a healer. This shows up with inflammatory markers coming down.  Cholesterol makes hormones, cells, and gives the cell membrane what it wants. Inflammation markers all dropped but all particles went up. The oxidative component rules. I’m using cholesterol as an energy source therefore I have more particles that are shuttling more cholesterol. Cholesterol becomes a major fuel source, makes sense.  Insulin resistance score 35 to 29 // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Let’s talk about some genetic SNP’s that are associated and supported in recovering autism. Single nucleotide polymorphisms, often referred to as SNPs (pronounced “snips”) are basic genetic variations in people. Respectively, in a DNA sequence. There are thousands of genes associated with AUTISM and all of them have been randomized out in clinical trials which tells us that autism is largely environmental! However, even though our genes do not define us, they can guide our way toward healing. Genetic susceptibilities come from trauma, both physical, emotional, and from toxic insult. Less than five percent of humans have genetic defects at birth. Some favorite SNP’s that can be associated and supported in recovering autism: MTHFR  It is estimated that 98% of people with autism have the MTHFR gene snip. MTHFR or methylenetetrahydrofolate reductase gene (methyl-ene-tetra-hydro-folate-reductase), when working properly, produces the MTHFR enzyme, MTHFR (5,10-methylenetetrahydrofolate reductase). However, if the gene is mutated it will not be able to make important compounds such as protein, and it disrupts the methylation cycle, otherwise known as detoxification. MTHFR gene mutation also disrupts the body’s ability to make the master antioxidant, glutathione. When the body cannot detoxify properly the toxins build up in the body and cause a myriad of health problems. MTHFR is also responsible for creating the process of converting the amino acid homocysteine to methionine. Methionine is the amino acid our body uses to make proteins. With the MTHFR mutation metabolic issues are common, and so is the deficiency of folate, vitamin Methyl B12 , (vital for proper function of many things including methylation, digestion and food absorption), and pyridoxine (vitamin B6, for brain function and coping with stress), or mutations of related enzymes. Folate is natural and comes from food sources such as green vegetables, beans and other whole plant foods. It is responsible for synthesizing DNA, making red blood cells, transporting oxygen, and supports the functioning of our nervous and cardiovascular systems. Adequate B vitamins, including folate are also necessary for proper cognitive function. Folic acid is synthetic and commonly in multivitamins and fortified foods. This can cause excess to build in the body. The body has a limited ability to convert folic acid to folate. Too much folic acid can affect gene expression, may reduce immune system function, and exacerbate vitamin B12 deficiency. It is critical to make sure to check your multivitamin, because most will contain folic acid and not folate. With the MTHFR mutation it is important to reduce inflammatory foods from the diet such as gluten, dairy, processed carbohydrates and sugars. detoxification and the use of toxin binders can be very helpful. Common health issues related to a disruption in the MTHFR gene are: Food allergies Inflammation Alzheimer’s Cardiovascular problems ADD/ADHD thyroid issues Chronic fatigue Eczema Infertility Drug sensitivities Tactile sensitivity A couple of physical signs to look for that refer to MTHFR are: A sacral dimple. This would be on the top and center of the gluteal fold. A blue line in between the eyebrows. Tongue tie Click Here for more details.

Gorilla Mind Smooth is the most potent and comprehensive stimulant-free Nootropic formula on the market. If you don't already know what Nootropics are, they are a category of compounds that can improve cognitive function. This can extend into many different specific benefits, but the main draw of Nootropics is their impact on productivity, concentration, creativity and information retention. Gorilla Mind Smooth is our stimulant-free version of Gorilla Mind that provides a smoother, much less extreme level of energy, but still maximizes mental clarity, memory, creativity and focus. Regardless if you're currently using stimulant-based products (coffee, energy drinks, pre-workouts, etc.), cycling off of stimulants, or just never use stimulants, Gorilla Mind Smooth is the most potent Nootropic formula you can add into your life to enhance cognitive function. https://youtu.be/Hcj8CinGG6s Reviews These are some of the reviews we've received from customers using Gorilla Mind Smooth: Gorilla Mind Smooth Supplement Facts Per Full Daily Dose: L-Tyrosine - 1000 mg Organic Lion's Mane Mushroom (Hericium Erinaceus) (standardized to 25% β-glucans) - 1000 mg DMAE (Dimethylaminoethanol) - 750 mg Alpha GPC 50% (L-alpha-glycerylphosphorylcholine) - 600 mg Kanna (Sceletium Tortuosum) - 500 mg Bacopa Monnieri (standardized to 45% Bacosides) - 400 mg L-Theanine - 200 mg Bioperine® (Black Pepper Fruit Extract) (standardized to 95% Piperine) - 10 mg Huperzine A (Huperzia serrata leaf standardized extract) - 400 mcg The original Gorilla Mind Smooth formula had PEA, Hordenine and Teacrine in it. Originally, I was trying to chase a stimulant-free energy boost in Smooth, which is why I had those ingredients in it. However, over the past year I've started to really lean towards reformulating Smooth to create an entirely Nootropic comprised formula that is 100% geared towards maxing out cognitive function, rather than chase a relatively weak level of energy that we already destroy with Gorilla Mind Rush. Anyone buying Gorilla Mind that is using it for the laser focus and massive boost in energy and productivity is buying RUSH anyways, not SMOOTH. Instead of wasting precious capsule space with things that achieve a subpar level of energy, I decided that space would be far better utilized with other Nootropics. This is what led to me creating the current Gorilla Mind Smooth formula, which now has 1000 mg of Lion's Mane mushroom and 500 mg of Kanna in it. These compounds are far more conducive to enhancing the SMOOTH formula by supporting actual brain health, creativity, mental clarity and memory formation. If you want ridiculous amounts of energy and drive, get RUSH. For those who want a true stimulant-free Nootropic formula, SMOOTH is even better now and I highly recommend you give it a try. Gorilla Mind Smooth Vs. Other Nootropics On The Market This is the most maxed out stim-free Nootropic formula on the market. The full daily dose is 6 capsules. Even a half dose (3 capsules) is still far more potent than the majority of other Nootropic formulas out there at their max dosages. I formulated Gorilla Mind Smooth the exact same way I formulate any other product. I put in exactly what I would buy myself if I were shopping for each Nootropic separately. If you thought the pre-workout market was bad for underdosed products, your jaw will drop when you see some of the top selling Nootropic formulas. This industry is even worse because it is so niche and new. Preying on unsuspecting customers with garbage formulas sprinkled with vitamins and completely useless dosages of Nootropics is even more common in this industry. Because Nootropics are relatively new and uncharted waters for many, the prices get pretty aggressive on these watered down formulas as well that promise the world, and deliver nothing more than placebo. What's baffling to me is how many people eat up the marketing and blindly buy products priced at $60, $70, even $100 that probably cost $4-5 max to make. When the cost of bottles, lids, and labels costs more than the Nootropics in your formula, there's a f*cking problem. Fortunately, my audience is comprised of intelligent individuals who actually know how to spot value. It would be so easy to make a formula with a couple hundred milligrams of cheap choline that doesn't even cross the blood brain barrier, 100-200 mg of Bacopa Monnieri, throw a bit of caffeine in there for a kick, put some exotic sounding ayurvedic herbs in there, maybe sprinkle a couple low dosed Adaptogens in there, add a useless pinch of vitamins to make my label look more impressive and confusing, and then slap a label on it like every other company and then aggressively smash people with ads and market a high priced subscription model to the masses, or put it up on Amazon to compete with all the other loss leader cheap and ineffective Nootropics on there. The fact that the hypothetical piece of sh*t formula I just made up as an example of what not to do is actually still better than most of the Nootropic formulas on the market just goes to show how much some companies are deceiving their customers. If the majority of a company's budget goes into ads and sponsorships instead of product formulation, or they have a high ranking product on amazon, you can almost guarantee without even looking at the product that it sucks. Unlike what most companies will lead you to believe, there is no Nootropic formula that will lock you in like Bradley Cooper from Limitless (great movie by the way). https://youtu.be/4TLppsfzQH8 Just like our other products, it is me making the formula, and I put in what I would want to use as a customer. I used to spend time every day in University measuring out all my different Nootropics that were in my "stack", and toss and washing random powders. Obviously it makes things much easier to just have it in ready to go capsules that are actually dosed properly. With my products, everything is turnkey. How To Dose Gorilla Mind Smooth Take 3-6 capsules in the morning, or spread throughout the day. Start with 3 capsules to evaluate your tolerance. While Gorilla Mind Rush requires more of a tolerance assessment and slow dosage titration over time due to the heavy hitting stimulants, you will more than likely be fine jumping head first into Gorilla Mind Smooth and tapering up to the maximum recommended dose relatively quickly. Gorilla Mind Smooth Vs. Gorilla Mind Rush While the foundation of Nootropics in both Gorilla Mind products are mostly the same, there are some key differences between the two formulas. The main difference is that RUSH has a handful of potent stimulants that completely change how the product feels. RUSH is best stimulant-based Nootropic formula on the market for really waking you up and giving you tunnel vision focus and productivity. The strong backbone of Nootropics in RUSH are the portion that can actually enhance information recall, creativity, etc. But, the stimulants in RUSH are the driving force of the product, and can really be a game changer in productivity. SMOOTH on the other hand is stimulant-free and has the same Nootropics as RUSH, but also has 1000 mg of Lion's Mane mushroom and 500 mg of Kanna. Lion's Mane is amazing for supporting cognitive health, memory formation and mental clarity, while Kanna is a potent mood booster and can also support improved focus and energy levels. Gorilla Mind Smooth is significantly toned down in the energy department, so if you have too high of a sensitivity to stimulants or simply want a smoother level of focus, this would be more ideal for you. How To Combine Gorilla Mind Rush And Gorilla Mind Smooth If you don’t want to pick between either having the giant burst of energy and laser focus that RUSH provides, or the cognitive enhancing benefits of the Lion's Mane and Kanna in SMOOTH, you can combine the products. By taking 6 capsules of either, you will be getting a top end dose of Nootropics. Even with 3 capsules of either product you will still get an effective dose of Nootropics, and with RUSH, many won't even be able to exceed 3 capsules because the stimulant blend is extremely strong. If you are not a stim junkie who needs 6 capsules of RUSH I would recommend getting both so you can strategically tweak how much energy you want to get from the Rush to not over-stimulate yourself, but also reach the maxed out mental benefit you would get out of the Nootropics in each respective version of the product. Rotating Gorilla Mind Smooth and Gorilla Mind Rush Use Gorilla Mind Rush on days that require the most focus, productivity and energy. By rotating RUSH and SMOOTH, you can keep yourself sensitive to the stimulants in Gorilla Mind Rush, and reap the maximum benefit from each product during each use. Do You Need To Cycle Off Of Gorilla Mind Smooth? While SMOOTH will not cause tolerance build up like RUSH, I would still advise cycling off of everything for a week every month or so. Alternatively, allocate a couple days each week to days you do not take anything, including RUSH. Gorilla Mind Smooth Ingredients Breakdown L-Tyrosine - 1000 mg L-Tyrosine is an amazing cognitive enhancing amino acid that acts by balancing neurotransmitter levels in the brain. Its primary role is as the direct precursor to thyroxine and to the neurotransmitters dopamine, epinephrine, and norepinephrine. L-Tyrosine shines in its ability to improve mental sharpness, focus, energy levels, and cause mood elevation [R, R]. L-Tyrosine Vs N-Acetyl L-Tyrosine L-Tyrosine is the most bioavailable form of Tyrosine. In short, N-Acetyl L-Tyrosine is very inefficiently converted by the body to Tyrosine [R]. Even IV’ing N-Acetyl L-Tyrosine can’t elevate plasma Tyrosine levels to a significant degree, let alone via oral ingestion. Claims of increased water solubility and bioavailability are all marketing hype and were disproved easily by showing just how poorly N-Acetyl L-Tyrosine is at converting to Tyrosine in the body. The graph above depicts arterial concentrations of N-Acetyl-L-Tyrosine (NAT) and Tyrosine (Tyr) during intravenous infusion of N-Acetyl-L-Tyrosine. As you can see, Tyrosine levels barely even budge. This is the same kind of tactic used to try and market new and “improved” forms of creatine that at the end of the day do not yield any additional benefit, and just feature an inflated price tag. In our first batch of Gorilla Mind, we actually had N-Acetyl-L-Tyrosine in the formulas based on these claims of improved water solubility and bioavailability by our manufacturer at the time. After delving into the data further, I realized the massive difference in bioavailability and swapped out the N-Acetyl-L-Tyrosine for straight L-Tyrosine, found a better manufacturing facility, and all batches of Gorilla Mind products since then have featured L-Tyrosine instead. Organic Lion's Mane Mushroom (Hericium Erinaceus) (standardized to 25% β-glucans) - 1000 mg Lion’s Mane is a Nootropic and cognitive-enhancing mushroom that has been used for thousands of years by Buddhist Monks who believed that it enhanced brain power and improved their focus. The main reason it is so promising as a Nootropic is the effect it has shown to have on the synthesis of nerve growth factor (NGF) and neurogenesis. By enhancing neurogenesis and potentially even attenuating the negative effects of cognitive decline, Lion’s Mane may significantly improve mental acuity, information retention, and decrease mental fatigue. Most products on the market contain 250 - 500 mg of Lion’s Mane. We have a full gram (1000 mg) in Gorilla Mind Smooth to ensure you are actually getting an efficacious dose of Lion’s Mane in when you use it. Effect On Cognitive Function A double-blind, placebo-controlled trial was conducted on 50-80 year old adults with mild cognitive impairment to evaluate the efficacy of Lion's Mane as a cognitive aid. The Lion's Mane treated group showed significantly increased scores on the cognitive function scale compared with the placebo group [R]. Enhanced Nerve Growth Factor (NGF) Synthesis Results from animal studies support that Lion's Mane can enhance the synthesis of Nerve Growth Factor (NGF) [R, R]. NGF is required by neurons in order to survive and appears to play a major role in cognitive function. When NGF decreases in the brain, memory formation and information recall becomes greatly impaired. By maintaining optimal levels of NGF one may be able to support brain plasticity for improved information retention, memorization, as well as general cognitive health. Effect On Beta Amyloid Levels And Cognitive Decline In a rodent model, Lion's Mane was shown to attenuate the negative cognitive effects of beta amyloid in the brain (what is believed to be the main cause of Alzheimer's) [R]. It was also shown to ameliorate Alzheimer’s disease-related pathologies in several other rodent models of Alzheimer’s disease [R, R]. Mood Elevation And Stress Reduction Lion’s Mane also contains erinacine and other bioactive compounds that may increase dopamine production and improve state of well-being. One study showed that Lion's Mane supplementation reduced depression and anxiety after 4 weeks of use [R]. DMAE (Dimethylaminoethanol) - 750 mg DMAE's mechanism of action isn't fully understood, but it appears to work primarily by stimulating cholinergic receptors and has shown to improve cognitive function, energy levels, focus, and act as a neuroprotectant [R]. DMAE users consistently report improved memory, attention to detail, focus and mental clarity. DMAE Vs. Ritalin Study One double-blind, placebo-controlled study conducted on 74 children with learning problems compared the efficacy of DMAE to Ritalin for treating ADHD [R]. The children were either given 40 mg of Ritalin, 500 mg of DMAE, or a placebo every day for 3 months. Behavior rating forms, reaction time, and an array of other psychometric tests were given before and after treatment. DMAE showed improvements in these metrics of approximately the same magnitude as Ritalin. No major side effects were noted with either treatment with exception of 6 of the children on Ritalin noting appetite suppression. Alpha GPC 50% (L-alpha-glycerylphosphorylcholine) - 600 mg Alpha-glycerylphosphorylcholine (Alpha-GPC) is the highest quality and most bioavailable form of Choline. Taking massive dosages of straight Choline has shown to have no cognitive effect in humans [R]. Alpha-GPC on the other hand has shown to cross the blood brain barrier and provide the brain with a rapidly absorbed form of choline. This then supports the synthesis and release of acetylcholine. The surge of quickly absorbed choline in conjunction with the release of acetylcholine helps support an array of cognitive functions including but not limited to memory, HGH production, physical performance, concentration, focus, and information absorption/recall [R, R, R]. Alpha-GPC has also shown to significantly increase strength and may be an effective ergogenic aid [R]. How Much Choline Do You Need Per Day? The Adequate Intake (AI), as established by the Food and Nutrition Board of the National Institute of Medicine, for adults is 550 mg per day for men and 425 mg per day for women. We all know how brutally underestimated some of the AI's have proved to be in the past couple decades, and there is evidence suggesting that the AI for Choline is also far too low. One study showed that 2200 mg per day of Choline protected against the DNA damage that otherwise occurred in people consuming only 550 mg [R]. There are not enough studies on Choline, and it is a severely lacking area of research considering how important it is for brain health. I would shoot for at least 900-1200 mg of Choline per day. A big chunk of that can be achieved through regular liver and egg yolk consumption, but supplementation will help you hit that number with much greater ease. I eat 1 ounce of beef liver, 4 large eggs, and supplement with 600 mg of Alpha-GPC every day via Gorilla Mind. I also take extra precautions to support methylation, which I will delve into later in the methylation subsection. Alpha-GPC's Effect On Alzheimer's Dementia In a double-blind, randomized, placebo-controlled trial, patients with Alzheimer's dementia were treated with Alpha-GPC (400-mg capsules) or placebo capsules, 3 times daily, for 180 days [R]. In the Alpha-GPC group, assessed parameters consistently improved after 90 and 180 days versus baseline, whereas in the placebo group those same parameters remained unchanged or worsened. The results suggest that Alpha-GPC is a promising intervention for attenuating the cognitive decline that occurs from neurodegenerative disease. Alpha-GPC's Effect On Methylation And Health Status The MTHFR gene codes for an enzyme called methylenetetrahydrofolate reductase, or MTHFR. This enzyme is needed for the production of DNA and supporting methylation pathways that are essential for all bodily functions. Genetic variations in this gene results in reduced activity of the enzyme and has been associated with cardiovascular disease, neurological defects, some forms of cancer, and a myriad of other diseases and disorders [R, R]. Personally, I am homozygous for C677T of MTHFR, which results in a 80-90% decrease in my efficiency in processing folic acid. The direct reflection of that in blood biomarkers can be high homocysteine and low B12 and folate levels. I determined this via a simple 23andMe genetics test. Normally your body creates methyl groups by recycling Homocysteine to Methionine, as well as by converting Choline to Betaine. When nutrient intake needs are sufficiently met, the body depends on these two mechanisms equally. However, if you are deprived of methyl groups or have poor MTHFR activity because of a polymorphism, you can change that and start to create a disproportional ratio of dependency on the Choline to Betaine pathway. If you can't create enough Methylfolate, your body will ramp up the use of Betaine and Choline for methyl groups. By ramping up Choline to Betaine conversion to support methylation, your body can become depleted of the Choline it needs to create Acetylcholine. Downstream, the depletion of Choline can eventually lead to impaired cognitive function, DNA damage, and can be deleterious to overall health. The prevalence of MTHFR polymorphisms and micronutrient deficient diets is so common nowadays that almost everyone could benefit from Alpha-GPC supplementation to maintain higher levels of Choline. I take 600 mg of Alpha-GPC every day on top of the Betaine and Creatine I get from Gorilla Mode (or Gorilla Mode Nitric when I am not taking stimulants) to support methylation, improve my health, and optimize my performance. Alpha-GPC Vs. CDP Choline Alpha-GPC raises choline blood levels much more than CDP-Choline. While there is some speculation around the fringe benefits that may come with the Cytidine component of CDP-Choline, in general, the main reason we would use either Alpha-GPC or CDP-Choline is to supplement our diet and raise our Choline levels. Alpha-GPC accomplishes this better than CDP-Choline. Our Alpha-GPC is 50% Choline by weight, whereas CDP-Choline is only about 18% Choline by weight. That means that you would need to use almost three times as much CDP-Choline to get the same amount of Choline as Alpha-GPC. Are any of the companies out there with CDP-Choline in their formulas putting 1600-1700 mg of CDP-Choline per daily dose in their products? Not even close. Many companies still use Citicoline (CDP Choline) in their Nootropic formulas, despite the fact that Alpha-GPC has shown time and time again to be more effective both anecdotally, as well as clinically [R]. From what I've seen, the most reputable anti-aging "biohackers" in the industry also prefer Alpha-GPC over CDP-Choline. I have personally tried CDP-Choline and never really noticed any enhancing effect like I seemed to with Alpha GPC. - Rhonda Patrick (Ph.D in biomedical science/expert on nutritional health, brain & aging) Kanna (Sceletium tortuosum) - 500 mg Kanna supplementation has been found to effectively lower stress, elevate mood and increase focus. Personally, I notice a huge boost in my mood and I lock in a little bit more on whatever I am trying to concentrate on when I supplement with Kanna. Kanna was a huge success in our pre-workout formula because it also complements stimulants very well, which you have probably found out first hand if you have tried Gorilla Mode. Kanna works mainly via increasing the amount of serotonin available in the brain, and is typically utilized for its anti-anxiety and mood elevating effects [R]. This is an ingredient you will really feel, and can be especially useful for those days you need something effective that isn’t stimulant based. Anecdotally, a dose between 200-500 mg of Kanna has shown to be ideal for oral ingestion. Higher dosages between 1-2 grams have been associated with unwanted side effects like dizziness. Kanna has no addictive properties, and it is not hallucinogenic [R, R]. One thing to keep in mind with Kanna use is that it has a high affinity for the serotonin transporter. Therefore, it is plausible that Kanna can interfere with SSRI pharmaceuticals. Bacopa Monnieri (standardized to 45% Bacosides) - 400 mg Bacopa Monnieri is typically used as a memory enhancing Nootropic. There is a growing body of evidence suggesting that Bacopa Monnieri can protect neurons in the brain from accumulative damage, reduce β-amyloid levels in the brain, and improve cognitive performance by modulating neurotransmitters [R]. The efficacy of Bacopa Monnieri has been reinforced in six high-quality randomized, double-blind, placebo-controlled human trials. The results suggest that Bacopa Monnieri not only has the potential to attenuate neurodegenerative disease progression, but it may also be a potent memory enhancing agent in otherwise healthy individuals. Improved Verbal Recall - Bacopa Monnieri Vs. Modafinil Study In a meta-analysis, long-term Bacopa Monnieri supplementation produced more consistent and noticeable positive effects than Modafinil [R]. Primarily, Bacopa Monnieri was shown to be very effective at improving verbal recall. This suggests that Bacopa Monnieri would be especially useful for memorizing long speeches, business presentations, songs, scripts, etc. Apparently Bacopa Monnieri was used by ancient Vedic scholars to memorize lengthy hymns and scriptures, which would reinforce the clinical findings. Improved Information Retention And Memory Consolidation A randomized double-blind placebo-controlled study conducted on 46 healthy adults assessed the efficacy of supplementing 300 mg per day of Bacopa Monnieri for 12 weeks [R]. 23 subjects received Bacopa Monnieri, and 23 subjects received placebo. A battery of well-validated neuropsychological tests were used to assess Bacopa's efficacy as a Nootropic. The Bacopa Monnieri treated group had significantly improved speed of visual information processing, learning rate, memory consolidation, and state anxiety compared to placebo, with maximal effects evident after 12 weeks. In another study conducted on 76 healthy adults aged 40-65, Bacopa Monnieri showed significant improvements in information retention [R]. Another study conducted on 81 elderly Australians found that a Bacopa Monnieri extract produced significant improvements in verbal learning, memory acquisition and delayed recall [R]. L-Theanine - 200 mg L-Theanine is most commonly used for its calming and relaxing effects. I find that it also promotes a high level of mental clarity as well. L-Theanine primarily works by targeting the neurotransmitters GABA, Serotonin, Dopamine, Epinephrine and Norepinephrine. These neurotransmitters are responsible for feelings of attention, stress, arousal, relaxation and pleasure. By mitigating the over-activity of excitable neurotransmitters and enhancing the calming neurotransmitters, L-Theanine seems to help calm down the brain, reduce stress, and curb anxiety. This is why L-Theanine complements stimulants like caffeine so tremendously too, as it takes the edge off of stimulants that can cause jitters and over-stimulation. Stacking Caffeine With L-Theanine To Help You Get To Sleep And Smooth Out The Jitters If you get jitters even with low doses of caffeine, the L-Theanine in Gorilla Mind Smooth will really help curb that. The caffeine + L-Theanine stack is one of the most basic and effective Nootropic stacks to date. This is one of the main reasons why Gorilla Mind Rush won't send you off the rails despite having a very potent combination of stimulants in it (it also has a big dose of L-Theanine in it). If you love your coffee, green tea, or energy drinks and don't want the aggressive stimulant blend in Gorilla Mind Rush, Gorilla Mind Smooth will stack with your caffeinated drink of choice exceptionally well. One notable rodent model even showed that L-Theanine can partially counteract caffeine-induced sleep disturbances [R]. Improved Memory And Attention In a randomized, double-blind, placebo-controlled study conducted on 91 people with minor brain damage, a combination of L-Theanine and green tea extract improved memory, attention span, and alertness during a memory test [R]. Improved Verbal Fluency And Executive Function In another randomized controlled trial, 30 healthy adults were given 200 mg of L-Theanine per day, or placebo. Verbal fluency and executive function scores improved after L-Theanine administration [R]. Stress levels also went down, and sleep quality also increased after L-Theanine administration. Improved Reaction Time In another study conducted on 18 healthy University student volunteers, 200 mg of L-Theanine improved attention performance and reaction time response [R]. Neuroprotection In a study conducted on elderly volunteers with normal or minor cognitive dysfunction, volunteers who ingested powdered green tea containing 47.5 mg of theanine per day showed significantly lower decline in cognitive function compared with that of the placebo group [R]. BioPerine® (Black Pepper Fruit Extract) (standardized to 95% Piperine) - 10 mg Bioperine is a trademarked form of black pepper extract standardized to 95% Piperine. Black pepper extract is a very effective CYP3A4 and P-glycoprotein inhibitor [R]. These enzymes break down molecules like epinephrine and norepinephrine in the body. By prolonging the breakdown of the cognitive enhancing ingredients in this formula, Bioperine extends how long they work for, and can also significantly increase their bioavailability. Huperzine A - 400 mcg Huperzine A works by inhibiting acetylcholinesterase in the brain, which is an enzyme that breaks down the neurotransmitter acetylcholine. Acetylcholine is not only a major regulator of cognitive performance, but it is also an important neurotransmitter needed for optimal muscular contractions during exercise. Huperzine A has shown to promote neurogenesis (the birth of new neurons in the brain) and act as a neuroprotective agent for existing neurons in the brain. In turn, Huperzine A has shown to enhance memory, focus and overall cognitive function [R, R]. Huperzine A is one of the most potent Nootropics that you can really “feel” and it complements the other Nootropics in this formula perfectly. Other Notable Compounds I Didn’t Include In The Formula And Why Noopept, Racetams, Other Synthetic Nootropics And Prodrugs Although they are effective Nootropics, Noopept, Racetams (class of drugs all named with the suffix "racetam"), prodrugs like Adrafinil,  and other synthetic compounds that cannot be found in nature or in the food supply are not DSHEA compliant and cannot be legally sold as dietary supplements, so we did not include any. If this wasn't the case, I probably would have included 30 mg of Noopept in the formula. I also like Phenylpiracetam. Vitamins Vitamins are often included in Nootropic formulas to make a supplement facts panel look more impressive. If a company is willing to sacrifice room in their capsules to inflate their ingredient profile with stuff you very likely already get from diet or a multivitamin, that is a major red flag. More often than not, the dosages included are next to useless and are just there to make a product look more comprehensive. The main issue with this is that you only have so much room in a capsule. Most Nootropic products use a "00" capsule size in their bottles. Each "00" sized capsule can fit about 735 mg in it. That is precious space, and including a useful amount of vitamins in a product can easily take up several capsules of space. If a company is wasting space with vitamins and only has a serving size of around 6 capsules, they are probably just trying to hide the fact that the actual Nootropics portion of their formula is watered down garbage. Conclusion - What To Expect From Gorilla Mind Smooth In general, you can expect clear headed mental clarity, as well as improved information retention, creativity, productivity and concentration. Gorilla Mind Smooth is not designed to jack your brain into high gear, as that is a stimulant driven mechanism. Rather, it is purely meant to enhance cognitive function and overall mental performance. Try Gorilla Mind Smooth for yourself here.

Let’s talk about some genetic SNP’s that are associated and supported in recovering autism. Single nucleotide polymorphisms, often referred to as SNPs (pronounced “snips”) are basic genetic variations in people. Respectively, in a DNA sequence. There are thousands of genes associated with AUTISM and all of them have been randomized out in clinical trials which tells us that autism is largely environmental! However, even though our genes do not define us, they can guide our way toward healing.  Genetic susceptibilities come from trauma, both physical, emotional, and from toxic insult. Less than five percent of humans have genetic defects at birth. Some favorite SNP’s that can be associated and supported in recovering autism: MTHFR  It is estimated that 98% of people with autism have the MTHFR gene snip. MTHFR or methylenetetrahydrofolate reductase gene (methyl-ene-tetra-hydro-folate-reductase), when working properly, produces the MTHFR enzyme, MTHFR (5,10-methylenetetrahydrofolate reductase). However, if the gene is mutated it will not be able to make important compounds such as protein, and it disrupts the methylation cycle, otherwise known as detoxification. MTHFR gene mutation also disrupts the body’s ability to make the master antioxidant, glutathione. When the body cannot detoxify properly the toxins build up in the body and cause a myriad of health problems. MTHFR is also responsible for creating the process of converting the amino acid homocysteine to methionine. Methionine is the amino acid our body uses to make proteins. With the MTHFR mutation metabolic issues are common, and so is the deficiency of folate, vitamin Methyl B12 , (vital for proper function of many things including methylation, digestion and food absorption), and pyridoxine (vitamin B6, for brain function and coping with stress), or mutations of related enzymes. Folate is natural and comes from food sources such as green vegetables, beans and other whole plant foods. It is responsible for synthesizing DNA, making red blood cells, transporting oxygen, and supports the functioning of our nervous and cardiovascular systems. Adequate B vitamins, including folate are also necessary for proper cognitive function. Folic acid is synthetic and commonly in multivitamins and fortified foods. This can cause excess to build in the body. The body has a limited ability to convert folic acid to folate. Too much folic acid can affect gene expression, may reduce immune system function, and exacerbate vitamin B12 deficiency. It is critical to make sure to check your multivitamin, because most will contain folic acid and not folate.   With the MTHFR mutation it is important to reduce inflammatory foods from the diet such as gluten, dairy, processed carbohydrates and sugars. detoxification and the use of toxin binders can be very helpful. Common health issues related to a disruption in the MTHFR gene are: Food allergies Inflammation Alzheimer’s Cardiovascular problems ADD/ADHD thyroid issues Chronic fatigue Eczema Infertility Drug sensitivities Tactile sensitivity A couple of physical signs to look for that refer to MTHFR are: A sacral dimple. This would be on the top and center of the gluteal fold. A blue line in between the eyebrows. Tongue tie   COMT   COMT stands for Catechol-O-methyltransferase and is an enzyme that breaks down hormones secreted by the adrenal glands to help us stay calm and handle stress. They are in a category of chemicals called catecholamines which are also neurotransmitters, or brain messengers, such as dopamine (our feel good chemical), epinephrine (also known as adrenaline), and norepinephrine (a stress hormone and a neurotransmitter). COMT deactivates these neurotransmitters in a process that uses S-adenosyl methionine, or SAMe. SAMe assists with many things including motivation. SAMe is part of the methionine cycle which needs the help of the MTHFR enzyme to complete these chemical processes. Therefore, MTHFR and COMT are both needed. A mutation in either one of these genes causes a disruption in the physical and emotional effects of the individual. Supplements that can be helpful: Magnesium is required for proper COMT function. Vitamin B6 is a cofactor to the COMT enzyme, so it can be helpful in its ability to be properly activated, but it must be added in slowly to avoid reactions.. Studies show “Catecholaminergic systems are involved in the regulation of aggressive behavior”. (Catecholamines and aggression: the role of COMT and MAO polymorphisms.) PON 1 The PON 1 gene relates to how our body’s metabolize organophosphates. It also relates to the susceptibility of vaccine reactions.  Histamine Sensitivity (DAO) Histamines are released by the digestive tract and the brain. When the DAO enzymes are mutated then it is difficult to remove histamine.  Histamine reactions come from the body having an allergic reaction. The body sees a food as an allergy when the immune system gets triggered to release histamine. Common symptoms are hives, extreme mood changes, poor sleep, Common causes are related to leaky gut and the MTHFR gene mutation. This can happen when an ill gut blocks methylation (MTHFR).  For SNP’s and autism health to become balanced it is crucial to heal the gut and regulate a proper diet, and avoid specific foods beginning with a food guide. In Summary The SNP’s or snips, MTHFR , COMT, MAO, and histamines can contribute or be the cause of both physical and behavioral issues such as manic or depressive behaviors, pain disorders, aggression, anxiety, poor sleep, food allergies, inflammation, and much more. By working with a supportive diet and natural supplementation we can improve these symptoms and the health and behavioral symptoms of autism. Diet is exceptionally important and the gut must be healed properly. Click Here for more details.

Welcome to the Cancer Secrets Podcast. In today's episode, Dr. Stegall addresses the most important factor you must incorporate into your anti-cancer nutrition plan: restricing methionine, the primary protein in animal products. To learn more, visit cancersecrets.com A pilot production of Eleven14 Studios at eleven14.com.

Dr. Paul Saladino, Carnivore MD, and I sit down to talk about the carnivore diet. In part 1, we focus on whether you can get all the vitamins and minerals you need on a carnivore diet, and how to best design a carnivore diet to maximize the nutrition you get. We discuss what I consider high-risk nutrients: Vitamin C Folate And what I consider conditional-risk nutrients: Manganese​  Magnesium​ Vitamin K​  Potassium​  Molybdenum​  We also chat about some other things: Dioxins in animal foods: a reason for vegetarianism?  The methionine-to-glycine ratio: balancing meat with bones and skin. Did paleo people get nutritional deficiencies? Bioindividuality: why we all have different needs and our needs evolve over time. Diversify to manage risk: does this mean eat plants, or just eat all the parts of an animal? Ketogenic diets and oxidative stress. Do carbohydrates give you more intracellular insulin signaling? Should carnivores eat dextrose powder for carbs? Are today’s hunter-gatherers representative of those from 80,000 years ago? Did the Maasai really mostly eat meat and milk? My open-door helicopter ride in Hawaii. Dr. Saladino completed residency in psychiatry at the University of Washington and is a certified functional medicine practitioner through the Institute for Functional Medicine. He attended medical school at the University of Arizona where he worked with Dr. Andrew Weil focusing on integrative medicine and nutritional biochemistry. Prior to this, Dr. Saladino worked as a physician assistant in Cardiology. It was during this time that he saw first hand the shortcomings of mainstream western medicine with its symptom focused, pharmaceutical based paradigm. He decided to return to medical school with the hope of better understanding the true roots of chronic disease and illness, and how to correct these. He now maintains a private practice in San Diego, California, sees clients from all over the world virtually, and has used the carnivore with hundreds of patients to reverse autoimmunity, chronic inflammation, and mental health issues. When he is not researching connections between nutritional biochemistry and chronic disease, he can be found in the ocean searching for the perfect wave, cultivating mindfulness, or spending time with friends and family.  Find more of Dr. Paul Saladino on the Fundamental Health podcast and at https://carnivoremd.com Get my free 9-page guide to optimizing vitamins and minerals on the carnivore diet at https://chrismasterjohnphd.com/carnivore  This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code “CHRIS15” at checkout for a 15% discount off your first order.” This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral In this episode, you will find all of the following and more: Masterjohn and Saladino Show Notes 2:11 Introductions 6:36 Dioxins in food.  14:33 Methionine to Glycine ratio. 23:08 Nutritional deficiencies in paleolithic people. 27:09 Bio individuality/diversity 36:07 Deficiencies that arise from eating only muscle meat. 37:26 Vitamin C 44:22 Weston A. Price’s documentation of whale stomach lining and moose adrenal as a source of vitamin C in Arctic diets. 56:03 Ketogenic diets, oxidative stress, and vitamin c.  58:36 Insulin 1:05:46 Antioxidant status. 1:22:44 Folate. 1:26:05 Riboflavin. 1:30:23 Manganese. 1:32:28 Dextrose powder. 1:37:31 Potassium/sodium. 1:52:37 Hunter gatherer diets now vs. 80 000 years ago. 2:03:05 The Maasai. 2:09:00 Vitamin K 2:19:00 The most radical thing I’ve done recently. 

Chris has a PhD in nutritional sciences, which he earned in 2012, from the University of Connecticut. He then did a post-doctoral fellowship before serving as an assistant professor at Brooklyn College until he decided to leave academia and do research on his own. He currently produces a radical podcast, Mastering Nutrition, writes about all kinds of cool stuff at chrismasterjohnphd.com, trains BJJ and loves his liver and egg yolks.    Chris’ contact info  Insta: @chrismasterjohnphd Twitter: @chrismasterjohnphd Web: www.chrismasterjohnphd.com 13:14 Dioxins in food.  19:15 Dioxins in organic animal food.  21:23 Methionine to Glycine ratio. 32:10 Nutritional deficiencies in paleolithic people. 34:10 Bio individuality/diversity 42:46 Deficiencies that arise from eating only muscle meat. 44:05 Vitamin C 51:10 Weston A. Price/the Arctic/scurvy risk. 1:03:10 Ketogenic diets, oxidative stress, and vitamin c.  1:04:47 Insulin 1:12:32 Antioxidant status. 1:29:07 Folate. 1:32:53 Riboflavin. 1:37:14 Manganese. 1:40:08 Dextrose powder. 1:44:07 Potassium/sodium. 2:01:40 Hunter gatherer diets now vs. 80 000 years ago. 2:10:40 The Maasai. 2:15:45 Vitamin K 2:25:40 The most radical thing Chris has done recently.  Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul   Native: For 20% off your first purchase, visit nativedeodorant.com and use promo code SALADINO during checkout! INSIDER: carnivoremd.com   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram: @carnivoremd Website: carnivoremd.com Twitter:@carnivoremd  Facebook: Paul Saladino MD email: drpaul@carnivoremd.com

The brilliant and articulate Paul Saladino MD - what a great discussion - see index below! For full TRANSCRIPT: https://thefatemperor.com/2958-2/ VIDEO PODCAST: https://www.youtube.com/watch?v=MqofVmSlj1A 00:00:51 Plant-Based good, Carnivore bad – it seems to most doctors 00:04:41 The baddest foods on the planet 00:08:04 Paleoanthropology – and how our bodies function best 00:12:48 The Vitamin C Conundrum - explained 00:18:00 Niacin and B Vitamins – what's the real deal? 00:20:24 What about the QUALITY of the meat you eat? 00:25:01 Global Warming – where is meat seated in the controversy? 00:29:54 The wisdom of our ancestors 00:32:34 Cholesterol and particle numbers – LDLp and ApoB – is the risk rational? 00:41:17 CAC and really getting to the bottom of things 00:45:59 Thomas Dayspring & the credibility of ApoBB Bullets shooting up your arteries 00:52:40 CAC and the “focal nature of atherosclerosis” 00:54:42 Watch dietary changes on blood markers – but don't discount carnivore benefits 00:56:49 Mikhaila Peterson, and the power of elimination in these diets 01:00:02 Plants can't run away – but they do have Lectin Defences 01:03:42 Beans, brains and autoimmune neurological disorders 01:08:05 Rhonda Patrick and the benefits of sulforaphane – or not?? 01:11:20 Tucker Goodrich, 4-HNE, seed oils – and the value of plants? 01:14:37 The fiber thing, the Plant Paradox and Dr. Steven Gundry. 01:17:45 Methionine and Glycine balance – and aging mice – what gives? 01:21:15 ApoE4, cheese and tallow – a complex equation 01:25:22 Lipopolysaccharides, plants and autoimmune maladies 01:29:00 A challenge - show me a disease that is not autoimmune that is chronic 01:29:45 The least toxic plant foods – listed in fairness

In this podcast Margo Hale, Regional Director of NCAT's Southeast Regional office in Fayetteville, Arkansas, talks with Dr. Anne Fanatico about ecological poultry production and alternative feeds for poultry diets. Anne teaches and conducts research at Appalachian State University in Boone, North Carolina. They talk about poultry feed and alternatives to the standard corn and soybean diet, including insects, worms, and potatoes. They also discuss practical tips for ecological poultry production. For more information on this topic, you can contact Margo Hale directly at margoh@ncat.orgRelated ATTRA Resources:Pastured Poultry Nutrition and ForagesPastured-Raised Poultry NutritionPoultry Production: Providing Adequate MethionineIntegrating Livestock and CropsVermicomposting: The BasicsOther ResourcesWebinar - Producing and Using Black Soldier Fly Larvae in Small Poultry FlocksSustainable Fish and Invertebrate Meals for Methionine and Protein Feeds in Organic Poultry Production - The Journal of Applied Poultry ResearchAmerican Pastured Poultry Producers AssociationFertrell Company - Natural and Organic Fertilizer, Soil Amendments and Livestock NutritionPlease call ATTRA with any and all of your sustainable agriculture questions at 1-800-346-9140 or e-mail us at askanag@ncat.org. Our two dozen specialists can help you with a vast array of topics, everything from farm planning to pest management, from produce to livestock, and soils to aquaculture.You can get in touch with NCAT/ATTRA specialists and find our other extensive, and free, sustainable-agriculture publications, webinars, videos, and other resources at NCAT/ATTRA's website.You also can stay in touch with NCAT at its Facebook page.Keep up with NCAT/ATTRA's SIFT farm at its website.Also check out NCAT's Regional Offices' websites and Facebook Pages!Southwest Regional Office: Website / FacebookWestern Regional Office: Website / FacebookRocky Mountain West Regional Office: FacebookGulf States Regional Office: Website / FacebookSoutheast Regional Office: Website / FacebookNortheast Regional Office: Website

In this podcast Margo Hale, Regional Director of NCAT's Southeast Regional office in Fayetteville, Arkansas, talks with Dr. Anne Fanatico about ecological poultry production and alternative feeds for poultry diets. Anne teaches and conducts research at Appalachian State University in Boone, North Carolina. They talk about poultry feed and alternatives to the standard corn and soybean diet, including insects, worms, and potatoes. They also discuss practical tips for ecological poultry production. For more information on this topic, you can contact Margo Hale directly at margoh@ncat.org Related ATTRA Resources: Pastured Poultry Nutrition and Forages Pastured-Raised Poultry Nutrition Poultry Production: Providing Adequate Methionine Integrating Livestock and Crops Vermicomposting: The Basics Other Resources Webinar - Producing and Using Black Soldier Fly Larvae in Small Poultry Flocks Sustainable Fish and Invertebrate Meals for Methionine and Protein Feeds in Organic Poultry Production - The Journal of Applied Poultry Research American Pastured Poultry Producers Association Fertrell Company - Natural and Organic Fertilizer, Soil Amendments and Livestock Nutrition Please call ATTRA with any and all of your sustainable agriculture questions at 1-800-346-9140 or e-mail us at askanag@ncat.org. Our two dozen specialists can help you with a vast array of topics, everything from farm planning to pest management, from produce to livestock, and soils to aquaculture. You can get in touch with NCAT/ATTRA specialists and find our other extensive, and free, sustainable-agriculture publications, webinars, videos, and other resources at NCAT/ATTRA's website. You also can stay in touch with NCAT at its Facebook page. Keep up with NCAT/ATTRA's SIFT farm at its website. Also check out NCAT's Regional Offices' websites and Facebook Pages! Southwest Regional Office: Website / Facebook Western Regional Office: Website / Facebook Rocky Mountain West Regional Office: Facebook Gulf States Regional Office: Website / Facebook Southeast Regional Office: Website / Facebook Northeast Regional Office: Website / Facebook

Join Logos Nutritionals John Burgstiner and Exercise Physiologist John Lehner and co-host Jachin Rutt as we discuss the Essential Amino Acids - Literally the building blocks of life.  Having the correct balance of amino acids in our bodies effects our whole person: mentally, emotionally, physically and spiritually.  Click the link below for more documentation. Essential Amino Acids Article.   Book recommendation by John Lehner regarding the relationship of humanity with their food and environment from a Christian Libertarian Author - Joel Salatin The Marvelous Pigness of Pigs.   The Logos Nutritionals Flyer of the week is presented by Glenn Edenfield and is worth the listen as he always entertains.  Use the coupon code AMINOHELP at checkout to save 15% off Logos' Pre-digested protein powder called Renaissance Activated Whey and their new Collagen product called REGEN Hydrolized Collagen Peptides as well as MSM 1000mg.

We’re back for the conclusion of this mighty animal vs. plant food discussion. Paul is a beast on this science and I think it’s really interesting to think about this in a whole new way than most of the mainstream nutrition world has for the past 60 years. We’re a day late because I’ve been desperately trying to launch my Grass Fed meat company Nose to Tail which you can find at NosetoTail.org which we mention in this episode. I couldn't release this episode until the website was live. So guess what? We’re now selling grass finished American-grown beef raised in the heart of America in Northeast Texas as of right now. I’ve spent over a year figuring this out and searching for the right ranch to partner with. My guy is the real deal. We have grass fed, grass finished beef, buffalo and lamb, pasture raised Omega-3 pork, and omega-3 chicken. We specially formulate the diet of the pigs and chicken for an incredible Omega-6 to Omega-3 ratio is 1.5:1 to 1.7:1. This is huge. If you’ve been listening to the experts I’ve been interviewing we want our ratio right around this range. We sent the pork and chicken to a lab for analysis and you can see the full fatty acid profile results on my site Nose To Tail.org. To give some context this blows away even pastured poultry at an 8:1 ratio and free range poultry at an 18:1 ratio. Our pork tested at 1.5:1 and conventional pork is 20:1. I’m most excited about the primal mixes. We have beef, buffalo, and pork primal mixes with either 30% organ meat mixed in or 5%. We’re talking liver, heart, kidney, and spleen. You can get all the extra nutrients without dealing with the taste that is harsh for some. At the risk of going on too long, we also are offering tins of cod liver in their own oil, wild caught sardines, and bone meal. These things round out the ultimate nose to tail diet and are what I’ve been eating regularly in my diet. So many great things with these including huge amounts of omega-3s, huge amounts of vitamin A, calcium, magnesium, phosphorous, the list goes on. Just check out NosetoTail.org and check out all the boxes and products. I’m so excited about this I can’t believe it’s finally here. This is such a win-win-win-win-win. It’s good for your health, it’s supporting an amazing ranch, it’s helping regenerate the soil and the environment, the animals are raised well and are happy, and it even supports me so I can keep putting out this content and finish the Food Lies film, etc. Thanks so much and I know you’re going to enjoy it. Now onto the rest of the discussion with Paul. We cover everything else you can imagine from coffee, more plant toxins, longevity and anti-aging research, the Blue Zones myth, advanced glycation end products and heterocyclic amines in cooked meat, mTor, the balance of Methionine to Glycine (which is another reason to eat Nose to Tail and why not buy it from NosetoTail.org and get the best stuff around), Paul’s workouts, inflammation, APOe4, safest plant foods, and more. This is an episode where you really need the extended show notes Kristi has been doing that are available to Patreon supporters. You can go to http://Patreon.com/peakhuman and support the show there and get access to the very comprehensive show notes she put tons of time into from this week and last, plus from Dr. Thomas Seyfried and Dave Feldman. So now you have a whole bunch of ways to support the show and the film from $2 on Patreon, to preordering the film and getting your name in the credits on Indiegogo, all the way up to a giant $200 box of grass fed meat delivered to your door. I really appreciate your support and let’s jump in with Paul and hear why eating nose to tail is so great. BUY THE MEAT NosetoTail.org   Show Notes Recap on last episode - fiber, polyphenols, plant toxins, no need for hormetic stressors when we can mimic them with lifestyle stressors such as exercise, cold stress, heat stress, etc. Risk of thyroid impairments from sulforaphane Bruce Ames paper: Dietary pesticides 99.99% all natural Carcinogens in coffee Dangers of oxalates Tea, coffee, and oxalates What are lectins and how do they disrupt the gut Phytic acid as a plant anti-nutrient Minerals in plants are bound to phytic acid and render them non-bioavailable Paul’s own personal cutting out grains and having major benefits on his stress fractures from ultramarathon running Resveratrol and its benefits but also its autoimmune potential Anti-aging research is becoming a stream of biohacking and using molecules instead of diet and lifestyle All the benefits from these anti-aging molecules can be achieved through living a “radical” life We have enough stressors in our modern environment, we don’t need more from plants Carcinogens and cooked meat Polycyclic Aromatic Hydrocarbons (PAHs) and Heterocyclic Amines (HCAs) in cooked meat and how to cook your meat to limit them Advanced Glycation End Products (AGEs) are in cooked plants and meat Acrylamide in coffee The dangers of a carnivorous lifestyle Environmental toxins in animal fat are no different than toxins in plants mTOR and why we shouldn’t be afraid of protein Insulin vs leucine effect on mTOR Building muscle on a carnivore diet Paleo anthropology perspective of a carnivore diet Problems with Blue Zones Genetics vs diet in Blue Zones Methionine-Glycine balance and why this is important Importance of calcium on a carnivore diet BUY THE MEAT http://NoseToTail.org Why you should consider adding bicarbonate to your water Flaws in the ethical argument for veganism Paul’s workouts What Paul’s currently questioning - APOE4 and saturated fat, endotoxins, electrolytes Meat and inflammation Would Paul feed his kids a carnivore diet? Safest plant foods Fermented foods Where to find Dr. Paul Saladino   Email: paulsalidinomd@gmail.com Instagram: @paulsaladinomd Website: www.paulsaladinomd.com Twitter: @mdsaladino Facebook: Paul Saladino MD   BUY THE MEAT http://NoseToTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Sapien Movement: http://SapienMovement.com   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg   Theme music by https://kylewardmusic.com/

I enjoy discussing all things nutritional biochemistry, and few minds are more engaging to chat with than David Quig, PhD, VP of Scientific Support at Doctor’s Data. In this NFFM podcast, we’re drilling down into the laboratory assessment of methylation and sulfuration. As Dr. Quig makes clear (yet again)--- while we might make some *basic* inferences around methylation activity by looking at a person’s SNPs, SNPs are not our destiny (thank God!). Ultimately, SNP assessment doesn’t hold a candle to direct assessment of key methylation intermediates. And indeed, we often find our biochemistry- i.e. what is actually happening in the body at any given time—is very, very different from what our SNP patterns suggest we might find. You’re going to want to hear what he has to say, so settle in because you’re going to learn a lot. And you’re not going to want miss the valuable downloads in the shownotes! ~DrKF

My guest on today's podcast and former guest on my show "", Dr. Steven Gundry proposes in his new book "", that the “diseases of aging” we most fear are not simply a function of age; but rather, they are a byproduct of the way we have lived over the decades. In The Longevity Paradox, he maps out a new approach to aging well—one that is based on supporting the health of the “oldest” parts of us: the microorganisms that live within our bodies. He believes that - from diseases like cancer and Alzheimer’s to common ailments like arthritis to our weight and the appearance of our skin, these bugs are in the driver’s seat, controlling our quality of life as we age. Dr. Gundry is a cum laude graduate of Yale University with special honors in Human Biological and Social Evolution. After graduating Alpha Omega Alpha from the Medical College of Georgia School of Medicine, Dr. Gundry completed residencies in General Surgery and Thoracic Surgery at the University of Michigan and served as a Clinical Associate at the National Institutes of Health. There, he invented devices that reverse the cell death seen in acute heart attacks; variations of these devices subsequently became the Gundry™ Retrograde Cardioplegia Cannula. It has become the world’s most widely used device of its kind to protect the heart from damage during open-heart surgery. After completing a fellowship in congenital heart surgery at The Hospital for Sick Children, Great Ormond Street, in London, Dr. Gundry was recruited as Professor and Chairman of Cardiothoracic Surgery at Loma Linda University Medical Center. There, he and his partner, Leonard Bailey, pioneered infant and pediatric heart transplantation. Together, they have performed more such transplants than any other surgeons in the world. During his tenure at Loma Linda, Dr. Gundry pioneered the field of xenotransplantation, the study of how the genes of one species react to the transplanted heart of a foreign species. He was one of the original twenty investigators of the first FDA-approved implantable left ventricular assist device (a kind of artificial heart). Dr. Gundry is also the inventor of the Gundry Ministernomy, the widely used minimally invasive approach to aortic- or mitral-valve repair, the Gundry Lateral Tunnel, a “living” tissue that can rebuild parts of the heart in children with severe congenital heart malformations; and the Skoosh™ venous cannula, the most widely used cannula in minimally invasive heart operations. One of the fathers of robotic surgery, as a consultant to Computer Motion (now ), Dr. Gundry received early FDA approval to use robotic-assisted minimally invasive surgery for coronary artery-bypass and mitral-valve operations. He holds patents on devices for connecting blood vessels and coronary artery bypasses without sutures, as well as for repairing the mitral valve without the need for sutures or a heart-lung machine. He has served on the Board of Directors of the American Society of Artificial Internal Organs (ASIAO), and was a founding board member and treasurer of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS). He recently completed two successive elected terms as President of the Board of Directors of the American Heart Association, Desert Division. Dr. Gundry has been elected a Fellow of the American College of Surgeons, the American College of Cardiology, the American Surgical Association, the American Academy of Pediatrics, and the College of Chest Physicians. He is a member of numerous other surgical and medical societies. He is also the author of more than three hundred articles, chapters, and abstracts in peer-reviewed journals on surgical, immunology, genetic, nutrition, and lipid investigations. He has operated in more than thirty countries, including charitable missions to China, India, and Zimbabwe. Inspired by the stunning reversal of coronary artery disease in an “inoperable” patient, using a combination of dietary changes and nutriceutical supplements, in 2001, Dr. Gundry changed the path of his career. An obese, chronic “diet” failure himself, he adapted his undergraduate Yale University thesis to design a diet based on evolutionary genetic coding, which enabled him to reverse his own medical problems. In the process, he effortlessly lost 70 pounds. The equally astonishing results from following what he came to call Diet Evolution in several of his staff led Dr. Gundry to accept a position in Palm Springs where he could devote his efforts to disease reversal. No longer satisfied with repairing the damage of chronic diseases, since 2002, Dr. Gundry founded and has served as Medical Director of The International Heart and Lung Institute in Palm Springs, California, which serves patients referred from across the nation. He is also Founder and Director of The Center for Restorative Medicine, part of the Institute. Its mission is to prevent and reverse the chronic diseases of “ageing” with diet and nutriceutical interventions, using surgical intervention for heart and vascular disease as a last resort. During our discussion, you'll discover: -The myth of the Mediterranean Diet promoting longevity...11:20 "Blue Zones" is a term coined by a journalist named Dan Bruckner Dr. Gundry has spent most of his life living in a Blue Zone (Loma Linda, CA) Doesn't disagree with the premise you should follow the Mediterranean Diet, but there's more to it... "The only purpose of food is to get olive oil in your mouth" The key to the Mediterranean Diet is not whole grains and beans Book: Residents of Acciaroli, Italy do not eat pasta or bread, but love lentil beans Millet, sorgum, teft do not have a hull (where most of the defense mechanisms of the plant are located) Unprocessed barley: People live a long time in spite of it, not because of it Influence of the Greek Orthodox church on the Mediterranean Diet Fasting and abstaining from animal products are observed during Lent -The missing link in the Mediterranean Diet regarding longevity...20:45 , a compound that is deleterious to the surface of blood vessels Cleveland Clinic invented a test to detect TMAO Recognized low incidence of coronary artery disease in spite of animal product consumption Present in most olive oils, balsamic vinegars and red wines A structural analog of choline Not all TMAO is created equal The ideal Mediterranean Diet (Hint: Olive Garden got it wrong) Rich in polyphenols, olive oil and red wine More fish and eggs than meat Some type of fasting component You can mitigate a bad diet with a fast or fasting mimicking diet for 5 consecutive days Done on a quarterly basis The Carnivore Diet is a fad, fancy name for the Atkins Diet -The carbohydrate Okinawans consume that staves off inflammation and high blood sugar...27:40 ~85% of the traditional Okinawan diet is a blue or purple sweet potato 5-6% of the diet white rice (no brown rice) Remaining soy-based products and pig fat Taro and sweet potatoes are resistance starches "The more we eat for our gut microbiome, the more our gut microbiome will take care of us." Nigerians carry the highest percentage of APO E-4 gene of any people on earth Their starch is melon Very low rate of Alzheimers -Dr. Gundry's thoughts on roughage and fiber intake...35:14  went on a mission to Africa to operate on colon cancer Realized no one had colon cancer Studied their stools Eating huge amount of tubers (yams) and millet Didn't realize there was a difference between soluble and insoluble fiber Advocated for eating whole grains Ended up dying of colon cancer Lives in tunnels in sub-saharan Africa Lives 30x longer than other rats Gut microbiome is identical of healthy 105 year old humans Eats tubers, roots and fungi -The myth of the efficacy of animal protein for longevity...42:45 US Dept of Agriculture sells agricultural products (owns the food pyramid) Vegans live the longest The more animal protein consumed, the less the longevity You can mitigate meat intake with a vegan fast or fasting mimicking diet for 5 days consecutively Methionine/glycine ratio People who are primarily carnivorous do not historically have the highest longevity -The myth of growth hormones...49:20 Loranz people of Ecuador do not have cancer or diabetes When block IGF-1 receptor in mice, live 40% longer When give growth hormones, abolishes effect of calorie restriction Supplement with quercetin -The myth of iron intake for longevity...55:05 Iron is one of the deadliest substances Iron is dangerous for mitochondrial function Regular blood donors have longer life spans than non-donors Endurance training helps reduce iron levels Ferritin and GGT are musts for a blood test to track "internal rust" Ferritin is a great marker for inflammation Elevated level indicates potential auto-immune disease -The myth of metabolic rate...59:50 Age is akin to rate of energy consumption Carnivores run higher temperatures than herbivores; breakdown of protein generates a lot of heat Sweet spot between fitness and low metabolism: Hibernating animals can live 2-3x longer than non-hibernating animals due to reduced metabolic rate There are periods we should have less energy expenditure than others We live in constant summer, regardless of where we live in the world -The myth of saturated fat...1:05:15 Dr. Ancel Keys published the Said saturated fat was related to coronary heart disease He did not say plant fats were bad for you (although it was implied) Retired near Acciorili and ate large amounts of olive oil Did not make the connection between animal fat and animal protein 30% of people carry APO E 4 gene Saturated fats in coconut oil, cheese increase LDL's in these people Mucus absorbs lectins; is essential for gut health in older age -Why milk does not in fact do the body good... Most milk in the US is casein a1 milk, from holstein cows Cow milk is designed to make baby cows grow quickly (lots of IGF1) Humans are designed to grow slowly (low amounts of IGF1) Adolescents who grow quickly have higher chance of cancer in 10-20 years We're the only animal that drinks another animal's milk Ben's kids drink goat and camel milk -And much more... Resources from this episode: -Book: -Book: -Book: -Book: - - - on the growing epidemic of loneliness and relationships/longevity. - - - - - - Episode Sponsors:  -: My personal playground for new supplement formulations. Ben Greenfield Fitness listeners receive a 10% discount off your entire order when you use discount code: BGF10. -: A new take on an ancient secret: Pain-soothing herbs, incredible antioxidants, and phytonutrients all in one delicious, soothing “Golden Milk” nighttime tea! Receive a 20% discount on your entire order when you use discount code: BENG20. -: You can be sure that I researched all the saunas before I bought mine and Clearlight was the one that stood out from all the rest because of their EMF and ELF Shielding and their Lifetime Warranty. Use discount code: BENGREENFIELD to get $500 off your sauna and a free bonus gift! -: As your qualified candidates roll in, we make it easy to screen & rate them, allowing you to make the best hiring decisions for your business. Try it for free when you use ! Do you have questions, thoughts or feedback for Dr. Gundry or me? Leave your comments below and one of us will reply!

I receive plenty of questions about peptides and SARMs, including: -How do peptides work? -What is the safety/side effects of peptides? -What are the best anti-aging peptides? -What are the best fat loss and muscle gain peptides? -What are the best recovery peptides? -What peptides work for cognition and neural enhancement? -How do you properly mix and administer peptides? -Do peptides need to be "cycled"? My guest on today's show, Jean-François Tremblay, comes highly recommended by former podcast guest and regenerative medicine physician Dr. Matt Cook as one of the world's leading experts on the wonderful world of peptides and SARMs. Dr. Tremblay studied Exercise Physiology, Biochemistry and Pharmacology. He has been investigating (in theory and in practice) peptides and SARMs since the 1990's and now makes peptides his main research subject. He has developed a wealth of expertise on peptides and SARMs and their practical applications in sports performance, anti-aging and health in general. During my discussion with Jean-François Tremblay, you'll discover: -The science of peptides and how they work...5:55 Amino acids linked together Growth hormone contains 191 amino acids When enough peptides link together, it becomes a protein Demistifying some of the myths surrounding peptides: They must be refrigerated at all times (only for certain peptides) Methionine bonds Most peptides are long chain, stable at room temp, More sensitive to light than heat (degradation more likely result of overexposure to light than heat) The "local effect" (BPC 157 and TB 500) -The pros and cons of various means of injecting peptides...15:15 Intra-nasal absorption is not 100%; however, what is injected has a better chance of reaching the brain Semax: Originally researched in USSR during the Cold War Russians are meticulous in their research; however, lacking in ethics  documentary Researched on humans before other animals; published only after testing on animals -Peptide safety and side effects of use...21:30 Worst-case scenario of "overdosing" on peptides is that it simply doesn't work; no notable negative side effects Not the case with nootropics; you're messing with the brain's chemistry Bottom line: Don't throw caution to the wind. Be aware of proper dosages and administer correctly to the best of your knowledge -Legality and sourcing issues with peptides...32:15 99% of them come from China (even if the label says "Made in the USA") Chinese government dictates who produces what, such as peptides Chinese company released a growth hormone which was very effective, then replaced it with another (under the same name) that had negative side effects Scandinavian company was dishonest about dosage of melanotan (5 mg when advertised as 10 mg) There are only a couple of sources, albeit distributed by many different brands The bacteriostatic water included with the peptide should be crystal clear when it's added There's a reason for the high cost: equipment, repairs, etc. -Whether peptides need to be "cycled" in their use...44:00 Some, yes. It depends on the peptide Effect of lasts around 6 hours Effect of TB-500 lasts 10-15 days; but it's out of your system in 12 hours -Recommended anti-aging peptides...49:30 The effects are not as immediate as peptides such as BPC-157 MOTS-c Humanan -The best peptides for fat loss...58:38 There is no "magic pill" Take care of the low hanging fruit: exercise, diet, etc. Tesamorelin (Egrifta) CJC-1295 (no dac version) -Recommended peptides for muscle gain...1:02:45 Nothing for non-competitive use Requires strict discipline and patience; marginal results at best -Jean-François' peptide regimen...1:04:51 Epitalon DSIP (affects the delta phase of sleep only) TB-500 (once a month) BPC-157 (once every couple of months) Thymus (timalin or vilon) twice a year Semax very occasionally -And much more... Resources from this episode: - (use code BEN for 15% off ) - - - - - - documentary Episode Sponsors: -: My personal playground for new supplement formulations. Ben Greenfield Fitness listeners receive a 10% discount off your entire order when you use discount code: BGF10.   -: After using the Joovv for close to 2 years, it's the only light therapy device I'd ever recommend. Give it a try: you won't be disappointed. Order using and receive nice bonus gift with your order!   -: Organic brands you love, for less. Your favorite organic food and products. Fast and free shipping to your doorstep. Receive 25% off your order when you use !   -: Quality is our Gimmick isn’t just our slogan, it’s a commitment we honor with every stitch we sew. 100% money back guarantee. Get 10% off your order, PLUS free shipping on any order over $99 when you use discount code: BENG. Do you have questions, thoughts or feedback for Jean or me? Leave your comments below and one of us will reply!  

Paul Saladino (@PaulSaladinoMD) is a classically trained MD, as well as a functional medicine practitioner. He received his MD from the University of Arizona in 2015 and has a IFMCP as well.   He went on to residency at the University of Washington in psychiatry. His interests include the autoimmune basis of psychiatric illness, connections between the microbiome and mental health, and nutritional biochemistry. In his practice, he is passionate about understanding and correcting the roots of disease.   Paul most recently has taken an interest in the carnivore diet as an intervention for health.   Dr. Saladino and I discuss the following: Hunting and balancing interests Plants as a essential vs. a possible toxin: Glutathione and sulforaphane IGF-1 and mTor - glycine methionine Glucagon and resistance through high protein Muscle meat carnivore vs nose to tail Too much vitamin A / vitamin deficiencies Catching up on glycine Bone meal and boron Electrolytes Dairy Losing weight on carnivore Counting calories And much more! Where to find out more about Paul: Website YouTube Instagram Twitter Patreon   What questions would you like answered or who would you like to hear from in the carnivore or research community?   Let me know on Twitter, Instagram, and Facebook. You can also email me at info@carnivorecast.com.

The holidays are here and boy are they fun! Some people think it's the most wonderful time of the year and I [Ginney] am one of those people. After all these years, I don't even TRY to kid myself that I am not going to enjoy my favorite holiday treats this time of year.  Oh, yes, I could demonize my favorite Queen Anne Chocolate Covered Maraschino Cherries or psyche myself out about the extra glass of really yummy red wine I will drink this Thanksgiving but I am not going to do that. What I am going to do is have LOTS of ReAline on hand and detox as I go.  That's right - instead of waiting for some crazy fad detox diet to start on January 1st, I am building my detox program the safe, healthy way every day the holidays are here so I can enjoy my favorite time of year and feel good in my body as well!. ReAline was the second formula that  Dr. Dean worked on after the RnA Drops. The current formula contains: Vitamin B1 (thiamine from Saccharomyces Boulardi) (natural source) – 4mg Vitamin B2 ( as Riboflavin 5 phosphate) – 4 mg Niacin (from Saccharomyces Cells) - 10 mg Vitamin B6 Pyridoxine 5 phosphate – 4 mg Folic acid (as Quatrefolic®) – 200 mcg Vitamin B12 (as Methylcobalamin) – 250 mcg Biotin (from Saccharomyces Cells) - 50 mcg L-Methionine (natural source) – 500mg L-Taurine (natural source) – 200mg Pantothenic Acid (from Saccharomyces Cells) - 6 mg ReAline is a specific formula that provides the perfect building blocks to enhance and assist the body in detoxifying chemicals and heavy metals. Instead of forcing the body with purges or IV chelation, ReAline has l-methionine, which is the building block for glutathione, the body's most important antioxidant. That way the body can detox when it wants to not when it’s forced to. L-methionine and l-taurine are sulfur amino acids, which help with the liver's sulfation detox pathways. The B vitamins work synergistically with magnesium and methionine. All four are methylated to help with liver methylated detoxification pathways to help break down toxic homocysteine. The introduction of methylated B’s became even more important as the MTHFR gene mutations were identified. Betaine HCL is also a methylated compound. Dr. Dean contends that gene mutations are expressed partly because of magnesium and other nutrient deficiencies. The B vitamins are essential to support our neurological health. This became even more obvious when we found deficient B12, B6, and folate in the autism spectrum and also in the elderly. But there is much more to them. They are cofactors in thousands of biochemical processes. The B vitamins work together; they help cells burn fats and glucose for energy, they promote cell growth and division, maintain healthy skin and muscle tone, support and increase the rate of metabolism, enhance immune and nervous system function, which includes easing stress and improving mood probably triggered by an increased production of serotonin. Their ability to help reduce anxiety, depression and PMS is enhanced with the use of magnesium. Methionine has 4 major roles in the ReAline formula. Methionine is a building block in the manufacture of all our proteins including: structural, contractile, blood proteins, antibodies, hormones, and enzymes. It is a methyl donor, needed for the production of neurotransmitters; a sulfur donor; and a precursor in the synthesis of other amino acids. Methionine has the ability to inhibit toxic metals from crossing the blood-brain barrier. Methionine is a critical component of tissue development, growth and tissue repair for all humans at any age. Taurine is a precursor to GABA; reduces elevated levels of cortisol in the body; helps burn fat; improves insulin sensitivity; increases testosterone production; acts as an antioxidant; enhances heart and brain function and improves sleep. It also lends sulfur molecules to the liver for its sulfation detox pathways. We hope that you take the appropriate steps to make good food and drink choices over the holidays. I know I will, and, I am keeping my ReAline close by to be a practical support to my body’s natural detoxification processes should I 'overindulge'.

The holidays are here and boy are they fun! Some people think it's the most wonderful time of the year and I [Ginney] am one of those people. After all these years, I don't even TRY to kid myself that I am not going to enjoy my favorite holiday treats this time of year.  Oh, yes, I could demonize my favorite Queen Anne Chocolate Covered Maraschino Cherries or psyche myself out about the extra glass of really yummy red wine I will drink this Thanksgiving but I am not going to do that. What I am going to do is have LOTS of ReAline on hand and detox as I go.  That's right - instead of waiting for some crazy fad detox diet to start on January 1st, I am building my detox program the safe, healthy way every day the holidays are here so I can enjoy my favorite time of year and feel good in my body as well!. ReAline was the second formula that  Dr. Dean worked on after the RnA Drops. The current formula contains: Vitamin B1 (thiamine from Saccharomyces Boulardi) (natural source) – 4mg Vitamin B2 ( as Riboflavin 5 phosphate) – 4 mg Niacin (from Saccharomyces Cells) - 10 mg Vitamin B6 Pyridoxine 5 phosphate – 4 mg Folic acid (as Quatrefolic®) – 200 mcg Vitamin B12 (as Methylcobalamin) – 250 mcg Biotin (from Saccharomyces Cells) - 50 mcg L-Methionine (natural source) – 500mg L-Taurine (natural source) – 200mg Pantothenic Acid (from Saccharomyces Cells) - 6 mg ReAline is a specific formula that provides the perfect building blocks to enhance and assist the body in detoxifying chemicals and heavy metals. Instead of forcing the body with purges or IV chelation, ReAline has l-methionine, which is the building block for glutathione, the body's most important antioxidant. That way the body can detox when it wants to not when it’s forced to. L-methionine and l-taurine are sulfur amino acids, which help with the liver's sulfation detox pathways. The B vitamins work synergistically with magnesium and methionine. All four are methylated to help with liver methylated detoxification pathways to help break down toxic homocysteine. The introduction of methylated B’s became even more important as the MTHFR gene mutations were identified. Betaine HCL is also a methylated compound. Dr. Dean contends that gene mutations are expressed partly because of magnesium and other nutrient deficiencies. The B vitamins are essential to support our neurological health. This became even more obvious when we found deficient B12, B6, and folate in the autism spectrum and also in the elderly. But there is much more to them. They are cofactors in thousands of biochemical processes. The B vitamins work together; they help cells burn fats and glucose for energy, they promote cell growth and division, maintain healthy skin and muscle tone, support and increase the rate of metabolism, enhance immune and nervous system function, which includes easing stress and improving mood probably triggered by an increased production of serotonin. Their ability to help reduce anxiety, depression and PMS is enhanced with the use of magnesium. Methionine has 4 major roles in the ReAline formula. Methionine is a building block in the manufacture of all our proteins including: structural, contractile, blood proteins, antibodies, hormones, and enzymes. It is a methyl donor, needed for the production of neurotransmitters; a sulfur donor; and a precursor in the synthesis of other amino acids. Methionine has the ability to inhibit toxic metals from crossing the blood-brain barrier. Methionine is a critical component of tissue development, growth and tissue repair for all humans at any age. Taurine is a precursor to GABA; reduces elevated levels of cortisol in the body; helps burn fat; improves insulin sensitivity; increases testosterone production; acts as an antioxidant; enhances heart and brain function and improves sleep. It also lends sulfur molecules to the liver for its sulfation detox pathways. We hope that you take the appropriate steps to make good food and drink choices over the holidays. I know I will, and, I am keeping my ReAline close by to be a practical support to my body’s natural detoxification processes should I 'overindulge'.

In this episode, my good friend David Sabatini delves into his extensive work with the mechanistic target of rapamycin—better known as mTOR—and rapamycin. The compound rapamycin is the only known pharmacological agent to extend lifespan all the way from yeast to mammals—across a billion years of evolution. David, a professor of biology and a member of the Whitehead Institute at MIT, shares his remarkable journey and discovery of mTOR in mammalian cells and its central role in nutrient sensing and longevity. Fasting, rapamycin, mTOR, autophagy, gedankenexperiments: having this conversation with David is like being the proverbial kid in the world’s greatest candy store. We discuss: mTOR and David’s student years [4:30]; Rapamycin and the discovery of mTOR [8:15]; The connection between rapamycin, mTOR, and longevity [30:30]; mTOR as the cell’s general contractor [34:45]; The effect of glucose, insulin, and amino acids on mTORC1 [42:50]; Methionine sensing and restriction [49:45]; An intermittent approach to rapamycin [54:30]; Rapamycin’s effects on cancer, cardiovascular disease, and neurodegeneration [57:00]; Gedankenexperiment: couch potatoes on rapamycin vs perfectly behaved humans [1:03:15]; David’s dream experiment with no resource constraints [1:07:00]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Ep. 269: What Is a Real Detox and What Is Bunk? In this episode, we discuss the difference between trendy detoxes and helpful ones and explain how your body really detoxes. Click here to listen in iTunes If you enjoy the show, please review it in iTunes! The Paleo View (TPV), Episode 269: What Is a Real Detox and What Is Bunk? News and Views (0:41) Sarah and Stacy are recording during the day, and Sarah isn't in her PJ's (for once!) Sarah's still tired because she's been recording videos for the Autoimmune Protocol Lecture Series videos all week. Stacy is excited about the next few shows because she got to pick the topics! After finishing Paleo Principles (which is 672 pages) Sarah went right into filming videos. Her feet have been swelling at night with no real explanation, and this got worse during filming. Sarah's FIFTH formulation of her thyroid medication has been working really well, and she is happy that she's lost some weight as a side effect. Stacy says that Sarah is a good example of weight loss coming on the heels of improved health. But it might also be triggering her swollen feet... The Truth About Detoxes This week's episode is Stacy's suggestion, but it comes at a great time because of Sarah's swollen feet! Sarah's Functional Medicine specialist suggested that estrogen stored in her fat, which was released during her rapid fat loss, might be causing the swelling in her feet. So, her doctor recommended a medical detox from Douglas Labs, which helped reduce the swelling right away! Stacy thinks there's a lack of education around other types of detoxes, as well as marketers who prey on "detox" searches on the web. Sarah says lots of detoxes have no grounding in science; a lot of them are fiber-rich and make you poop a lot. Another example is the coffee enema, which can actually be dangerous. Read Sarah's post "Coffee Enemas: What the Science Says versus What You've Heard" for more. Interestingly, lots of detoxes, like juice cleanses, can have immediate beneficial effects because you're eating more veggies and pulling out inflammatory foods (such as FODMAP's and alcohol). However, they're not a good solution because they starve your beneficial gut bacteria. Detoxification happens in the liver, but these cleanses don't support the liver. Most "Toxins" are fat-soluble, including heavy metals, metabolic by-products, and excess hormones. Liver detox: Phase 1: Liver transforms them into water-soluble forms. Nutrients for this include B Vitamins, Vitamin A, Magnesium, Zinc, Selenium. Phase 2: Conjugation - the water-soluble molecule is combined with something to neutralize it, and by-products are secreted into small intestine and eliminated or sent to kidneys and eliminated Nutrients for this include Amino Acids, Glutamine, Methionine, Taurine, Cysteine, Vitamin B and C, Selenium. Liver stores the nutrients needed for detoxification, so eating liver (or taking Vital Proteins Liver Pills) is a great "detox" strategy. Fiber from veggies (especially non-starchy), water, organ meats, bone broth, seafood, and fruit are all great detox foods - i.e. the Paleo diet! It's also important to stay hydrated. If your liver can't keep up, supporting Phase 1 or Phase 2 with botanicals like Milk Thistle can be helpful. This is what a medical detox looks like; it should only be done under a doctor's supervision. In contrast, most detoxes just clear out your good bacteria and don't support your liver at all. Stacy really doesn't like that companies use misleading "marketing techniques" to convince people to buy their detox products that don't work. Find a good functional medicine doctor to work with! Stacy and Sarah both love Vital Proteins beef liver pills. Rate and review us. Goodbye! Outro (53:09) Support us by shopping through links on our sidebars, please!

Protein is constantly one of the hottest topics in all of nutrition, do you need shakes? how much should I have every day and does the anabolic window exist?  Durham and Jacob go into depth on all things protein, from what it even is, where you can get it, the importance of post workout nutrition and whether or not you might need protein shakes. NB: One thing we didn't cover is how many total grams you should be having every day. For athletes doing high-intensity training (strength, power, hypertrophy, sprint, or conditioning training) aim for 1g of protein for every KG of body weight as a MINIMUM. Even better is to hit 1.5g/kg every day. Spreading it evenly throughout the day with a decent serve (20-30g) right around your workout. Some resources: Our own article about protein is a great starting place for all things protein http://www.coreadvantage.com.au/blog/2015/protein101 Protein is a key building block not just for muscles but also our neurotransmitters, hormones and enzymes (like mTOR) Neurotransmitters and hormones #1 https://www.youtube.com/watch?v=hBl5WODNr6M Neurotransmitters and hormones #2 https://www.youtube.com/watch?v=53_qmY4WxBQ a good intro to mTOR https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin  BCAAs are a contentious topic, but we believe they can be a big part of the puzzle especially for hard training athletes. The key BCAA is Leucine https://examine.com/supplements/leucine/ There are 20 amino acids, the 9 essential amino acids are:  - Histidine, - inflammatory agent as part of the immune response - Isoleucine, - One of the three BCAA amino acids - Leucine, - the muscle growth and mTOR trigger (the most important BCAA) - Lysine, - Plays a role in calcium absorption, tissue repair, and hormone production - Methionine, - Helps the generation of new blood vessels. A lack of methionine can lead to greying of hair - Phenylalanine, - The key precursor tyrosine and then to dopamine, adrenaline and noradrenaline - Threonine, - Precursor to glycine which in turn is a key component of collagen protein (tendons and ligaments) - Tryptophan, - the precursor for serotonin (the happiness neurotransmitter) and melatonin (the sleep hormone) - Valine. - the third BCAA The other 11 amino acids are broken into non-essential: alanine,  asparagine,  aspartic acid,   glutamic acid. And conditional (may need more of these in certain extreme situations): arginine,  cysteine,  glutamine,  tyrosine,  glycine,  ornithine,  proline,  serine Durham was totally onto something with the brain protein connection. While the brain is mostly fat (60%) protein is the second most abundant molecule and is a key component of heaps of vital neurotransmitters. https://memory.foundation/2012/02/14/why-your-brain-needs-protein/ Whether you have your shake before, during or after the workout doesn't seem to matter, what really matters is having that serving of fast digesting protein and carbs in the system when your body needs it most. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214805/ And finally, what protein powder is best? Most of the brands are very similar (despite the range of claims they make on the packages). We recommend avoiding the mass gainers as these are high in maltodextrin (a simple carbohydrate).  WPI is the best for post workout (fastest digesting), but soy, pea, and WPC all work fine. Hemp powder is less ideal post workout but might be a good snack or meal on the go, while casein is perfect for pre-bed as it is super slow digesting. You shouldn't have to spend any more than $50 a kg for WPI and $40 for WPC (buying 3-4kg at a time will bring the price down heaps)

Purges and IV chelation are the most common forms of detox for the body. But what if there were a more perfect way? ReAline is a specific formula that provides the perfect building blocks to enhance and assist the body in detoxifying chemicals and heavy metals. Instead of forcing the body with purges or IV chelation, ReAline has l-methionine, which is the building block for glutathione, the body's most important antioxidant. That way the body can detox when it wants to now when it’s forced to. There is no practical way to protect yourself from all the toxins in the environment. You would have to live the rest of your life in a hermetically sealed suit (and it would be a short life since you couldn’t eat or drink.) Fortunately, there are ways to counteract some toxins and pollutants. Your body’s natural detoxification processes exist to deal with the ones we can’t avoid. ReAline was the second formula that I worked on after the RnA Drops. It contained three B vitamins and two sulfur-based amino acids dl-methionine and l-taurine. Specifically, the original ReAline formula contained: B2 (riboflavin-5-phosphate), B6 (pyridoxine-5-phosphate), Folate, dl-Methionine, l-Taurine, and Betaine hydrochloride (a methylated compound). Since that formula was first released in 2011, we have changed all the B’s to active, methylated forms, added methylated B12, included a natural source of l-methionine, and most recently [beginning January 2017], included a food-based B1(thiamine). Here is the current formula, which can replace several supplements that you may be taking: Vitamin B1 (thiamine from Saccharomyces Boulardi) (natural source) – 4mg Vitamin B2 ( as Riboflavin 5 phosphate) – 6mg Vitamin B6 Pyridoxine 5 phosphate – 8mg Folic acid (as Quatrefolic) – 990mcg Vitamin B12 (as Methylcobalamin) – 500mcg L-Methionine (natural source) – 500mg L-Taurine (natural source) – 200mg Betaine HCL – 100mg Other Ingredients: Vegetable cellulose (capsule shell), Cellulose, Vegetable Stearate, Silica Now that ReAline is a more perfect formula, I suppose it’s time I wrote a booklet about all the amazing ingredients! However, for now, let me expand on how ReAline is described at RnA ReSet. I want to make sure you realize how important it is for you and your Total Body ReSet. Tonight on our show we'll talk about ReAline, the Total Body Reset and much more!

Purges and IV chelation are the most common forms of detox for the body. But what if there were a more perfect way? ReAline is a specific formula that provides the perfect building blocks to enhance and assist the body in detoxifying chemicals and heavy metals. Instead of forcing the body with purges or IV chelation, ReAline has l-methionine, which is the building block for glutathione, the body's most important antioxidant. That way the body can detox when it wants to now when it’s forced to. There is no practical way to protect yourself from all the toxins in the environment. You would have to live the rest of your life in a hermetically sealed suit (and it would be a short life since you couldn’t eat or drink.) Fortunately, there are ways to counteract some toxins and pollutants. Your body’s natural detoxification processes exist to deal with the ones we can’t avoid. ReAline was the second formula that I worked on after the RnA Drops. It contained three B vitamins and two sulfur-based amino acids dl-methionine and l-taurine. Specifically, the original ReAline formula contained: B2 (riboflavin-5-phosphate), B6 (pyridoxine-5-phosphate), Folate, dl-Methionine, l-Taurine, and Betaine hydrochloride (a methylated compound). Since that formula was first released in 2011, we have changed all the B’s to active, methylated forms, added methylated B12, included a natural source of l-methionine, and most recently [beginning January 2017], included a food-based B1(thiamine). Here is the current formula, which can replace several supplements that you may be taking: Vitamin B1 (thiamine from Saccharomyces Boulardi) (natural source) – 4mg Vitamin B2 ( as Riboflavin 5 phosphate) – 6mg Vitamin B6 Pyridoxine 5 phosphate – 8mg Folic acid (as Quatrefolic) – 990mcg Vitamin B12 (as Methylcobalamin) – 500mcg L-Methionine (natural source) – 500mg L-Taurine (natural source) – 200mg Betaine HCL – 100mg Other Ingredients: Vegetable cellulose (capsule shell), Cellulose, Vegetable Stearate, Silica Now that ReAline is a more perfect formula, I suppose it’s time I wrote a booklet about all the amazing ingredients! However, for now, let me expand on how ReAline is described at RnA ReSet. I want to make sure you realize how important it is for you and your Total Body ReSet. Tonight on our show we'll talk about ReAline, the Total Body Reset and much more!

Purges and IV chelation are the most common forms of detox for the body. But what if there were a more perfect way? ReAline is a specific formula that provides the perfect building blocks to enhance and assist the body in detoxifying chemicals and heavy metals. Instead of forcing the body with purges or IV chelation, ReAline has l-methionine, which is the building block for glutathione, the body's most important antioxidant. That way the body can detox when it wants to now when it’s forced to. There is no practical way to protect yourself from all the toxins in the environment. You would have to live the rest of your life in a hermetically sealed suit (and it would be a short life since you couldn’t eat or drink.) Fortunately, there are ways to counteract some toxins and pollutants. Your body’s natural detoxification processes exist to deal with the ones we can’t avoid. ReAline was the second formula that I worked on after the RnA Drops. It contained three B vitamins and two sulfur-based amino acids dl-methionine and l-taurine. Specifically, the original ReAline formula contained: B2 (riboflavin-5-phosphate), B6 (pyridoxine-5-phosphate), Folate, dl-Methionine, l-Taurine, and Betaine hydrochloride (a methylated compound). Since that formula was first released in 2011, we have changed all the B’s to active, methylated forms, added methylated B12, included a natural source of l-methionine, and most recently [beginning January 2017], included a food-based B1(thiamine). Here is the current formula, which can replace several supplements that you may be taking: Vitamin B1 (thiamine from Saccharomyces Boulardi) (natural source) – 4mg Vitamin B2 ( as Riboflavin 5 phosphate) – 6mg Vitamin B6 Pyridoxine 5 phosphate – 8mg Folic acid (as Quatrefolic) – 990mcg Vitamin B12 (as Methylcobalamin) – 500mcg L-Methionine (natural source) – 500mg L-Taurine (natural source) – 200mg Betaine HCL – 100mg Other Ingredients: Vegetable cellulose (capsule shell), Cellulose, Vegetable Stearate, Silica Now that ReAline is a more perfect formula, I suppose it’s time I wrote a booklet about all the amazing ingredients! However, for now, let me expand on how ReAline is described at RnA ReSet. I want to make sure you realize how important it is for you and your Total Body ReSet. Tonight on our show we'll talk about ReAline, the Total Body Reset and much more!

Purges and IV chelation are the most common forms of detox for the body. But what if there were a more perfect way? ReAline is a specific formula that provides the perfect building blocks to enhance and assist the body in detoxifying chemicals and heavy metals. Instead of forcing the body with purges or IV chelation, ReAline has l-methionine, which is the building block for glutathione, the body's most important antioxidant. That way the body can detox when it wants to now when it’s forced to. There is no practical way to protect yourself from all the toxins in the environment. You would have to live the rest of your life in a hermetically sealed suit (and it would be a short life since you couldn’t eat or drink.) Fortunately, there are ways to counteract some toxins and pollutants. Your body’s natural detoxification processes exist to deal with the ones we can’t avoid. ReAline was the second formula that I worked on after the RnA Drops. It contained three B vitamins and two sulfur-based amino acids dl-methionine and l-taurine. Specifically, the original ReAline formula contained: B2 (riboflavin-5-phosphate), B6 (pyridoxine-5-phosphate), Folate, dl-Methionine, l-Taurine, and Betaine hydrochloride (a methylated compound). Since that formula was first released in 2011, we have changed all the B’s to active, methylated forms, added methylated B12, included a natural source of l-methionine, and most recently [beginning January 2017], included a food-based B1(thiamine). Here is the current formula, which can replace several supplements that you may be taking: Vitamin B1 (thiamine from Saccharomyces Boulardi) (natural source) – 4mg Vitamin B2 ( as Riboflavin 5 phosphate) – 6mg Vitamin B6 Pyridoxine 5 phosphate – 8mg Folic acid (as Quatrefolic) – 990mcg Vitamin B12 (as Methylcobalamin) – 500mcg L-Methionine (natural source) – 500mg L-Taurine (natural source) – 200mg Betaine HCL – 100mg Other Ingredients: Vegetable cellulose (capsule shell), Cellulose, Vegetable Stearate, Silica Now that ReAline is a more perfect formula, I suppose it’s time I wrote a booklet about all the amazing ingredients! However, for now, let me expand on how ReAline is described at RnA ReSet. I want to make sure you realize how important it is for you and your Total Body ReSet. Tonight on our show we'll talk about ReAline, the Total Body Reset and much more!

Today we tackle the subject of SAMe.  SAMe is a nutrient that we make in our liver but also has documented benefits from supplementing it in the diet.  It stands for S-adenosyl methionine, and it plays a significant role in methylation in our body.  It has been shown in research to help with various concerns including depression, osteoarthritis, pain syndromes, fibromyalgia, chronic fatigue syndrome, and mood/attention concerns. In this podcast, we talk about how SAMe works in the body, who would benefit from taking it and supplementation levels. It also plays a role in methylation and genetic concerns like MTHFT and COMT.  In this podcast, we touch briefly about these concerns and how you can incorporate SAMe supplementation to help support the body and promote optimal health and wellness.   Here is a link to our course on methylation and epigenetics if you would like to find out more: http://courses.beyondthebasicshealthacademy.com/courses/epigenetics-methylation-and-mastering-your-genome  

Dr. Ben Lynch is a naturopathic doctor and world expert on MTHFR genes and methylation problems. In this episode, we talk about the many ways that methylation problems can affect health, especially for women. What is MTHFR? The methylenetetrahydrofolate reductase (MTHFR) gene produces the MTHFR enzyme, which is responsible for breaking down (methylating) folate in the body. Up to 50% of Americans have an MTHFR gene defect of some type that impairs their ability to mthylate properly. These defects can cause problems with everything from nutrient absorption to gene expression. The methylation of folate is also important for healthy homocysteine levels and hormone levels because one of the byproducts of methylation us used to break the amino acid homocysteine down to another essential amino acid, methionine. The body uses methionine to make proteins, utilize antioxidants, and to assist your liver in processing fats. Methionine into SAM-e (s-adenosylmethionine) in the liver. SAM-e is important for reducing inflammation, neurotransmitter production, and cell repair. In short, a methylation problem can lead to a build up of heavy metals and synthetic vitamins in the body. It can also prevent proper neurotransmitter production and lead to problems with mental health, cellular health, autoimmune disease, infertility, miscarriages and even cancer. Resources Mentioned Dr. Ben Lynch’s website MTHFR.net SeekingHealth.com (my source for many supplements) Article: MTHFRs and Toxicity Article: Benefits of Sauna and how to sauna safely with MTHFR Article: Optimizing Your Future Child-Prenatal Supplements Article: Nitrous Oxide and MTHFR Book: Drug Muggers by Suzy Cohen Educational Course: Kids Course Supplements Dr. Ben Suggests: Optimal Prenatal Protein Powder Active B12 with L-5-MTHF Lozenge Histamine Block – for food derived histamine issues Optimal Liposomal Vitamin C

Support Cell Energy Production and Reduce Inflammation with Power Restore. Specially formulated to help athletes recover from tough workouts, it reduces inflammation, oxidative stress, and improves the way our our cells make energy.   What is unique about this product is the synergistic blend of specific nutrients that when used together, allow your body to recover from workouts. One of these nutrients is Curcumin, which is derived from the spice Turmuric. It has been highly researched and proven to reduce inflammation.   Also included is a group of amino acids, such as Methionine, Citruline, Arginine, and Ornithine that are utilized in the electron transport chain to help our cells make energy.   In addition, a blend of antioxidants, are also in this product, such as N-acetylcysteine (NAC), ALA, Resveratrol, Quercetin, and CoQ10. If you want to learn more about the importance of antioxidants you can go to Triton Nutrition's library.   When you begin using Power Restore, it is suggested by Robert Seik to take 2 capsules before a workout and 1 capsule right after. For the average individual who trains to maintain their physique, Power Restore would also benefit them by improving recovery time, reducing inflammation to prevent future injuries and increasing energy.   By Robert Seik, PharmD