Podcasts about metabolites

Welcome to The Trainer's Scoop! In Episode 89, we're welcoming a great guest back to the podcast, Daniel Courtney. Daniel is a former high level Gaelic Football athlete, and is currently pursuing a graduate degree in a Exercise Science related field.In our discussion, Daniel and I debunk some of the misconceptions we've noticed both on social media, and that we've had in our past as well. There's a ton of good takeaways and framework you can use for creating a system that works for you, so tune in and enjoy!Here's the timestamps!0:00 - 9:00 - Do You Need A Surplus? 9:00 - 15:00 - Lifting/Life Balance15:00 - 27:30 - Does Muscle Damage Contribute to Growth?27:30 - 35:30 - Misconceptions from Socials35:30 - 47:00 - Our Dogmatic mistakes47:00 - 54:30 - The importance of developing sound technique54:30 - 1:05:00 - Sticking To The Plan 1:05:00 - 1:17:00 - Metabolites & Hypertrophy1:17:00 - 1:19:30 - There's More To Discover 1:19:30 - 1:30:00 - How To Program 1:30:00 - 1:33:33 - Closing Thank you all so much for watching/listening! Be sure to follow Daniel!https://www.instagram.com/science_basedphysiquetraining/Share this episode around with your friends and family! And as always, thank you so much for the support, if you liked this episode or learned something, please leave the podcast a positive review on Spotify and Apple Podcasts***If You Need Help Structuring A Training & Nutrition https://www.dmarttraining.com/work-with-me________________________________________________________________________________________________If you caught the ad in the podcast, I'm working with Raw Nutrition, a company that makes great supplements with the right dosing, great flavors, and business ethics. You can use my code DMARTIN070 at checkout for a 10% discount, which directly helps me put out podcasts like this! For more of The Trainer's Scoop, follow me on IG: https://www.instagram.com/dmart_training/

When we talk about PCOS, the conversation often revolves around fertility struggles. While this is undoubtedly a major aspect, PCOS carries a range of long-term health risks, including endometrial cancer, diabetes and heart disease. By understanding these risks and taking proactive steps, you can help future-proof your health and lower the chances of complications as you age. Let's dive deeper into some of the serious health risks associated with PCOS - and explore what you can do to reduce those risks.If this episode resonated with you, we'd love for you to share and leave a review! Links: PCOS Recovery Program - Starts April 23rd References: Chen W, Pang Y. Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites. Metabolites. 2021 Dec 14;11(12):869. doi: 10.3390/metabo11120869. PMID: 34940628; PMCID: PMC8709086. Diabetes Canada. (n.d.). Diabetes in Canada. Retrieved March 27, 2025, fromDiabetesdiabetes.ca/advocacy-policies/advocacy-reports/national-and-provincial-backgrounders/diabetes-in-canadaDiabetesdiabetes.ca/advocacy-policies/advocacy-reports/national-and-provincial-backgrounders/diabetes-in-canada Helena Teede et al. International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023. Monash University. https://doi.org/10.26180/24003834.v1Johnson JE, Daley D, Tarta C, Stanciu PI. Risk of endometrial cancer in patients with polycystic ovarian syndrome: A meta‑analysis. Oncol Lett. 2023 Mar 8;25(4):168. doi: 10.3892/ol.2023.13754. PMID: 36960190; PMCID: PMC10028221.

***JOIN THE NEXT MASTER YOUR FASTING CHALLENGE THAT STARTS March 19th, 2025!*** We'll GUIDE you how to FAST to LOSE FAT for good, and use 'fast cycling' to achieve uncommon results! REGISTER HERE! Click the Link for DATES, DETAILS, and FAQs! In this science-backed episode, Dr. Scott Watier and Tommy Welling analyze recent research from the Journal of Nature Communications revealing how intermittent fasting combined with protein pacing transforms gut health and metabolism in ways traditional calorie counting can't match. The hosts break down the surprising findings showing how fasting plus protein pacing creates a more diverse gut microbiome, increases fat-burning metabolites, and improves metabolic flexibility while reducing inflammation. They explore why fasting participants naturally increased their protein intake beyond recommendations and experienced greater reductions in visceral fat while maintaining muscle mass. This episode offers practical guidance on finding a sustainable macronutrient balance without extreme restrictions, making it easier to stick with healthy eating patterns long-term while enjoying better results than traditional dieting approaches. Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting! Resources and Downloads: SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! - December 2024 FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! SLEEP GUIDE DIRECT DOWNLOAD DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE! Partner Links: Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Our Community: Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://www.r2mprotocoldetox.com/wp-content/uploads/2024/10/Nature-Communications-Journal.pdf https://www.r2mprotocoldetox.com/wp-content/uploads/2023/10/Jama-Study.pdf

In this special episode, you get to join me in a doctor's appointment and lm tell you… what you don't know about hormone tests could be the difference in feeling 10x better and aging better too!  If you don't know about hormone tests that there are not only different test, but different ways to interpret them from norms to optimal….if you don't know that some doctors don't know all test and couldn't order them if they did because they don't know how to interpret them… then you're in for a treat…. And education!  My Guest: Dr. Sharon Stills is a Naturopathic Medical Doctor providing comprehensive health care, therapeutic and diagnostic services to patients worldwide. She combines her conventional medical training, data-driven science, cutting-edge diagnostic tools and a deep knowledge of natural healing to effectively identify and treat health concerns ranging from allergies to end stage cancer, and everything in between Questions We Answer in This Episode: Why do a Wet Urine Test? [00:02:18] What are Metabolites? Why do they matter when it comes to your hormones? [00:04:35] How does Estrogen impact your body and what can you do to keep them in balance? [00:04:41] Why is Testosterone important to women? How can you support healthy levels? [00:27:01] What does DHEA do and how can you optimize it? [00:29:17] How can you accurately Cortisol? What does it mean for your stress levels? [00:37:01] How can you boost Oxytocin naturally? [00:38:37] How does Thyroid affect your metabolism, energy, and mood? What can you do to balance it? [00:43:17] Connect with Dr. Sharon: https://www.flippingfifty.com/drsharon  On Social:Instagram: https://www.instagram.com/drsharonstills/  Other Episodes You Might Like: Circadian Rhythm Hacks for Muscle in Menopause: https://www.flippingfifty.com/Circadian-Rhythm-Hacks  Can I Still Start Hormones 10 Years After Menopause? Doctors Respond: https://www.flippingfifty.com/start-hormones-10-years-after-menopause  Which Hormones Matter Most in Meno(pause): https://www.flippingfifty.com/which-hormones  Resources: 5-Day Flip: https://www.flippingfifty.com/5dayflip  Sleep Yourself Skinny: https://www.flippingfifty.com/sleep-yourself-skinny   

New studies reveal that meat from grass-fed beef contains higher levels of micronutrients and health-promoting compounds compared to pasture-raised alternatives. Support your Intermittent Fasting lifestyle with the Berberine Fasting Accelerator by MYOXCIENCE:  Use code podcast to save 12% Save on microplastic free underwear from nadsunder.com Coupon Code: HIH Link to Research: https://bit.ly/3PRn9nz Research Mentioned: Vliet, S. van, Provenza, F. D. & Kronberg, S. L. Health-Promoting Phytonutrients Are Higher in Grass-Fed Meat and Milk. Front. Sustain. Food Syst. 4, 555426 (2021). Vliet, S. van et al. Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat. J. Anim. Sci. Biotechnol. 14, 49 (2023). Time Stamps: 0:00 - Intro 0:04: Grass fed meat versus the conventional feedlot meat? 1:00 Pasture Raised Bison 2:04 Polyphenols in meat 3:07 Human Health 3:45 Nads Organic Cotton Boxers 5:00 Grass-fed VS Grain fed differences 5:30 Metabolic Health of Animals 6:48 Buy local 6:52 The Rumen 9:55 Metabolites  

Dr. Adrian Gombart, professor of biochemistry and biophysics at Oregon State University is researching the benefits of hops.

In this episode, we dive into the interplay between the gut microbiota (their postbiotics) and the immune system. We will examine how gut microbiome-derived metabolites, such as short-chain fatty acids (SCFAs) and polyphenol metabolites, influence immune function by modulating key cellular and molecular pathways within the intestinal mucosa. Additionally, we discuss strategies for supporting butyrate production and optimizing microbiome health to foster a balanced and resilient gut-immune axis. Topics: 1. Introduction Overview of the gut-immune axis. Importance of gut microbiome-derived metabolites in supporting immune function. 2. The Intestinal Barrier Layers of the intestinal wall Focus on mucosa, specifically the epithelium and lamina propria. 3. Structure of the Intestinal Layers The intestinal lumen, mucus layer, epithelium (with tight junctions), and lamina propria. Importance of the lamina propria as a hub for immune responses and structural integrity. 4. Cellular and Structural Components of the Lamina Propria Extracellular matrix (ECM): structural support. Fibroblasts and myofibroblasts. Lymphatic vessels: immune cell transport, linking mucosal and systemic immune systems. 5. Immune Cells in the Lamina Propria T cells: immune tolerance, regulatory T cells (Tregs). B cells: Secretory immunoglobulin A (sIgA). Dendritic cells: antigen sampling and presentation. Macrophages: pathogen clearance. Mast cells 6. Role of Secretory Immunoglobulin A (sIgA) Functions as a first-line defense in the intestinal mucus layer. Neutralizes pathogens, prevents epithelial adhesion. 7. Postbiotics Overview Bioactive compounds produced by gut microbiota. Examples: short-chain fatty acids (SCFAs) 8. Short-Chain Fatty Acids (SCFAs) and Their Functions Influence on Treg cells in the lamina propria, promoting immune tolerance. Butyrate also as an energy source for epithelial cells. 9. Supporting Butyrate Production Microbiome optimization to enhance beneficial butyrate-producing microbes. Use of prebiotics: resistant starch, soluble fibers, and polyphenols. Supplementation with sodium butyrate as an additional tool. 10. Other Postbiotics Antimicrobial peptides produced by beneficial microbes. Complex carbohydrates produced by beneficial microbes and can act as prebiotics. Polyphenol metabolites: Gut microbiota biotransforms polyphenols into bioactive metabolites with increased bioavailability. 11. Specific Polyphenols Examples: resveratrol, quercetin, and ellagitannins. Effects on intestinal barrier function, inflammation, and immune cell populations. "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

The history of fermented foods like beer, bread, and other foods can be traced back thousands of years to ancient civilizations in China and Egypt. This ancient technology was originally used to preserve foods when refrigeration was not an option. While less common in modern industrialized civilizations, we're now realizing that fermented foods play a major role in gut microbiome diversity, which is a biomarker for overall health. Join our conversation with Dr. John Leech, Technologist at Teagasc in County Cork, Ireland to learn all about the history and how cutting-edge technologies are being applied to research in food fermentation. John shares his story of how he found this field of research and how he's now headlong into striving to understand and harness the power of fermented foods. We learn about the complex microbial communities that define and deliver the health benefits of these foods, but we also hear about how this biological complexity makes them inherently irreproducible. Foods like kimchi, sauerkraut, kombucha, tepache, milk kefir, and water kefir are produced from fermentation, facilitated by complex communities of microbes. Consumption of fermented foods can alter our gut microbiome, which has been shown to affect obesity, inflammation, longevity, and efficacy of drug treatments. John and his team are using qPCR, NGS, and other methods to characterize the microbial consortia used to produce these foods. They're now working to figure out how to simplify the consortium while still delivering health benefits, all while making the process reproducible and scalable Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Download Transcripts: Speaking of Mol Bio Podcast | Thermo Fisher Scientific - US Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology.

In this episode, we sit down with Shawn Wells, "The World's Greatest Formulator," to explore the hidden detriments behind caffeine addiction and how it may be negatively impacting our health and energy levels. He shares more on paraxanthine, a novel compound that could offer a better solution for those seeking enhanced focus and alertness without the negative side effects of caffeine. We also delve into the fascinating world of psychedelics, discussing both micro- and macro-dosing, and how these practices can unlock new pathways for mental health, creativity, and well-being. Shawn's voice has resonated on international platforms and is a globally acclaimed nutritional biochemistry expert, revered as “The World's Greatest Formulator” in the supplement industry. With over 2 decades of experience, he has formulated more than 1100+ products, which are distributed worldwide. He holds over 40 patented novel ingredients, including market-leading innovations such as efinityⓇ (Paraxanthine), diluecine, TeaCrine and Dynamine. As a nutritional biochemist, Registered Dietitian, and Certified Sports Nutritionist, Shawn has notably been a Fellow in the International Society of Sports Nutrition and has over ten years of experience as a Chief Clinical Dietitian in both acute hospital and skilled nurse settings. Having overcome personal health challenges including Epstein-Barr virus, Chronic Fatigue Syndrome, Fibromyalgia, depression, insomnia, obesity, and a pituitary tumor, Shawn stands as a beacon of hope and information resource for countless individuals. His passion for health and wellness is further evident through his contributions in masterminds, conferences, magazines and TV appearances worldwide.SHOW NOTES:0:51 Welcome to the show!6:27 Shawn Wells' Bio7:42 Welcome him to the podcast!10:03 Habituation vs Dependence11:18 3 Metabolites of Caffeine14:18 The Benefits of Paraxanthine15:30 Studies on Paraxanthine vs Coffee22:43 Origin and Purpose of Caffeine in nature23:56 Green Tea structure & benefits26:42 “Drinking caffeine today is stealing energy from tomorrow”30:21 How to keep the ‘coffee experience'32:20 *Cycle Care Ad*34:55 Addicted to the frazzle41:40 His favorite class of supplements44:20 Impact on Adrenals & Nervous System46:30 Drink Update's ingredients49:07 Paraxanthine in supplement-form50:12 Lauren's experience with multi-tasking50:49 Echo-dosing53:27 Micro vs Macro-dosing57:21 Biology of Belief1:00:56 Renee's medicine experiences1:02:15 Finding safety in facilitators & NLP1:06:24 Respecting other's beliefs1:08:05 Imbalance in Feminine vs Masculine1:13:28 Self-love vs Self-loathing1:23:42 Where to find Drink Update1:24:41 Thanks for tuning in!RESOURCES:DrinkUpdate.com - Discount code: BIOHACKERBABESIG: DrinkUpdateenfinityenergy.comhttps://shawnwells.com/https://www.instagram.com/shawnwells/https://www.energyformula.com/https://www.youtube.com/c/shawnwellshttps://www.facebook.com/Ingredientologisthttps://www.linkedin.com/in/ingredientologist/Amazon: The Energy FormulaEpisode #94: The Energy Formula with Shawn WellsBiOptimizers' Cycle Care - code: biohackerbabes10Our Sponsors:* Check out Puori and use my code BIOHACKERBABES for a great deal: puori.com* Check out Timeline and use my code BABES20 for a great deal: www.timeline.comSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Do you understand the role that metabolites have in your health? Depending on the health of your liver, even good foods and substances can cause the creation of damaging metabolites. Here's how that works and what you can do about it.Trying to find an integrative medicine or functional medicine doctor who understands what you're going through? Lam Clinic does Telemedicine all over the world and is only a phone call away.1. Educate yourself by visiting our website: www.lamclinic.com2. Call our office at 714-709-8000 to schedule an appointment.FIND US ONLINE HERE:» Website: https://www.lamclinic.com/» Facebook: https://www.facebook.com/lamclinic» Instagram: https://www.instagram.com/lam_clinic/» Tiktok: https://www.tiktok.com/@lamclinic» YouTube: https://www.youtube.com/LAMCLINIC

In this episode, we dive into how short-chain fatty acids (SCFAs), particularly butyrate, and tryptophan metabolites support the gut-immune axis by promoting regulatory T cell differentiation, strengthening the intestinal barrier, and enhancing antimicrobial defenses through IL-22 signaling. We break down how butyrate can improve immune tolerance as well as epithelial integrity, aiding in the prevention of chronic inflammatory responses. We also detail practical ways to support butyrate levels and aid in strengthening both the epithelial barrier and gut-immune axis. Topics: 1. Introduction - Overview of the role of SCFAs and tryptophan metabolites in supporting the gut-immune axis. - Quick review of the location of immune cells in relation to the gut microbiota. 2. The Intestinal Barrier - Structure of the intestinal wall and layers - Focus on the mucosal layer, specifically epithelium and lamina propria. 3. The Lamina Propria - Structural elements: fibroblasts, extracellular matrix (ECM), and myofibroblasts. - Vascular components: endothelial cells, capillaries, and lymphatic vessels. - Importance of the lamina propria as a hub for immune responses. 4. Immune Cells in the Lamina Propria - T cells: Role of regulatory T cells (Tregs) in immune modulation. - B cells: Production of IgA, class switching, and plasma cells. - Dendritic cells: Sampling luminal antigens and initiating immune responses. - Macrophages: Phagocytic activity, pro-inflammatory (M1) vs. anti-inflammatory (M2) states. - Mast cells: Role in allergic responses, chronic inflammatory conditions, and MCAS. 5. Short-Chain Fatty Acids (SCFAs) - Production of SCFAs (acetate, propionate, butyrate) by gut microbiota. - Butyrate's role in supporting regulatory T cell (Treg) differentiation and immune tolerance. -Butyrate as fuel for epithelial cells and the production of tight junction proteins. 6. Mechanisms of Butyrate in Immune Modulation - Impact on Tregs through FoxP3 expression. - SCFA's role in maintaining immune balance. 7. Butyrate and Epithelial Integrity - Support for tight junction protein expression. - Prevention of translocation of harmful microbes and antigens. - Reduced systemic inflammation through a strengthened barrier. 8. Supporting Butyrate Production - Sodium butyrate supplementation and microbiome optimization. - Role of fiber, polyphenols, and probiotics. 9. Tryptophan Metabolites - Overview of tryptophan metabolism by gut bacteria into indoles. - Indoles' role in promoting IL-22 production, contributing to antimicrobial defense and immune tolerance. 10. IL-22 - IL-22's enhancement of antimicrobial peptides (AMPs) and mucin production. - Case Study: Role of Lactobacillus strains in restoring IL-22 and helping to mitigate colitis. 11. Conclusion - Recap of how SCFAs and tryptophan metabolites interact with the gut-immune axis. - Importance of gut microbiome support for maintaining immune balance. Thank you to our episode sponsor: 1. Check out ⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠ and use code ⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠ for 20% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In today's episode, we dive into the crucial roles that gut-derived microbial metabolites, particularly short-chain fatty acids and tryptophan metabolites, play in supporting the health of neurons and glial cells, ultimately promoting cognitive function. We explore how enhancing the body's natural production of these metabolites through a healthy gut microbiome and how strategic supplementation can both benefit brain health. The discussion includes detailed insights into the cellular mechanisms in the brain and practical strategies for fostering a healthy gut microbiome capable of producing high quantities of these beneficial compounds. Topics: 1. Introduction to Brain Cellular Makeup - Overview of Neurons and Glial Cells - Neurons: Structure and Function - Glial Cells: Types and Roles 2. Neuronal Communication and Synaptic Function - Neuronal Structure: Soma, Dendrites, Axon - Synaptic Communication: Presynaptic Terminal, Synaptic Cleft, Postsynaptic Membrane 3. Energy Demands - ATP Utilization and Energy Demands - Mitochondrial Function and Neuronal Vulnerability 4. Astrocytes and Microglial Cells - Astrocytes: Functions and Role in CNS Homeostasis - Microglial Cells: Immune Functions and Role in Neuroinflammation 5. Roles of Gut-Derived Microbial Metabolites in Supporting Brain Health - Overview of Gut-Derived Metabolites - Short-Chain Fatty Acids (SCFAs): Acetate, Propionate, Butyrate - Tryptophan Metabolites: Indole, Indole-3-Propionate (IPA) 6. Impact of Gut-Derived Metabolites on Neurons - Promotion of Neurogenesis by SCFAs - Neuroprotective Effects of Tryptophan Metabolites 7. Impact of Gut-Derived Metabolites on Glial Cells - Impact on Astrocytes - Impact on Microglial Cells 8. Strategies to Enhance Metabolite Production - Diversity - Probiotic Supplementation - Fiber - Amino Acids 9. Direct Supplementation Options - Sodium Butyrate: Role in Neuroprotection and Cognitive Function Thank you to our episode sponsors: 1. Check out ⁠Daily Nouri⁠ and use code ⁠CHLOE20⁠ for 20% off your order. 2. Check out ⁠⁠AX3 Astaxanthin⁠⁠ and use discount code ⁠⁠CHLOE20⁠⁠ for 20% off your first order. 3. Check out ⁠⁠⁠⁠⁠⁠Liver Medic and use code Chloe20 to save 20% on ⁠⁠⁠⁠⁠⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠⁠⁠⁠⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In today's episode, we delve into a groundbreaking new study that explores brain changes following spinal adjustments. We'll unpack the study "The Application of Spinal Manipulation Results in Alterations in Thalamic Neural Metabolites Among Patients Experiencing Nonspecific Chronic Low Back Pain." This research illuminates how chiropractic adjustments can significantly affect brain function and pain perception, offering deeper insights into the mechanisms behind the relief and functional improvements our patients experience.Episode Notes: The Application of Spinal Manipulation Results in Alterations in Thalamic Neural Metabolite among Patients Experiencing Nonspecific Chronic Low Back PainJane is an online platform for health and wellness practitioners that makes it simple to book, chart, schedule, bill, and get paid. I you're ready to get started, click here and use the code EBC1MO for a 1-month grace period on your new account.The Best Objective Assessment of the Cervical Spine- Provide reliable assessments and exercises for Neuromuscular Control, Proprioception, Range of Motion, and Sensorimotor-Integration. Learn more at NeckCare.comInterested in ShockWave technology? I built a practice using StemWave and can't recommend it enough. Learn more at- https://gostemwave.com/theevidencebasedchiropractor Patient Pilot by The Smart Chiropractor is the fastest, easiest to generate weekly patient reactivations on autopilot…without spending any money on advertising. Click here to schedule a call with our team.Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!

The development and application of epigenetic predictors of health is revolutionizing the way we understand and approach personalized medicine. These predictors, derived from analyzing DNA methylation patterns, provide a powerful tool for assessing biological age, disease risk, and overall health.By leveraging advanced machine learning and AI, researchers can identify specific epigenetic markers that correlate with various health outcomes, allowing for early detection and tailored interventions.The ability to accurately predict health outcomes and aging processes not only offers individuals a roadmap for healthier living but also promises to reduce healthcare costs by focusing on prevention rather than treatment.In this week's episode of the Everything Epigenetics podcast, Dr. Varun Dwaraka and I discuss practical applications of epigenetics, such as the development of epigenetic clocks for measuring biological age. We explain the concept of epigenetic clocks and the different generations of these clocks, emphasizing the importance of reproducibility and association with clinical outcomes.Varun also introduces how machine learning and AI are used to create Epigenetic Biomarker Proxies (EBPs), developed in collaboration by TruDiagnostic and Harvard, which can provide detailed health insights from a single blood sample. We also cover the significant implications of EBPs, including cost reduction and personalized supplement recommendations from a single blood sample.In addition, we compare methylation risk scores to epigenetic biomarker proxies, providing a clear understanding of their differences and applications.Lastly, Varun shares current exciting areas of discovery and ongoing projects, offering a glimpse into the future of epigenetic research and its potential to revolutionize personalized health.Varun is currently the Head of Bioinformatics at TruDiagnostic and sits on the faculty at the Geneva College of Longevity Science. In this episode of Everything Epigenetics, you'll learn about:Varun's dissertation that covered epigeneticsWhy studying epigenetics is important How epigenetics offers valuable insights into gene expression patterns and the upstream factors contributing to themThe landscape of epigenetic clocks The best bioinformatic practices when developing such clocksStochastic and dynamic aging Validation of epigenetic clocksEpigenetic biomarker proxies (EBP) Ongoing research aiming to expand the list of EBPs Methylation risk scores (MR')EBP vs. MRSChapters: 00:00 Introduction and Commendation 05:21 The Growth of Epigenetics 11:41 Defining Epigenetic Clocks 14:08 Best Bioinformatic Practices 24:55 Stochastic Aging vs Dynamic Aging 26:49 Best Practices in Bioinformatics and the Importance of Validation 33:08 Epigenetic Biomarker Proxies: Estimating Values for Proteins, Metabolites, and Clinical Biomarkers 36:53 Expanding the List of Epigenetic Biomarker Proxies and Improving Accuracy 45:11 Areas of Discovery: Twins and Connecting Molecular Data to Physiological OutcomesSupport the Show.Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.

Welcome back to the Stronger Bones Lifestyle Podcast. In Episode 72, host Debi Robinson welcomes Dr. Bahar Amin, a a board certified functional anti-aging, metabolic regenerative, and family doctor, to discuss the importance of hormone awareness and management for women's health, particularly during perimenopause.As a  conventionally trained physician who takes a holistic and integrative approach in managing patient health, Dr. Bahar shares her passion for empowering women with knowledge about the hormonal changes, imbalances, and symptoms experienced during perimenopause. She emphasizes the need to address root causes rather than relying solely on medications to treat symptoms such as mood swings, fatigue, weight gain, and sleep problems.Throughout the episode, Debi and Dr. Bahar delve into the role of hormones in bone health, discussing the benefits of bio-identical hormone therapy in preventing osteoporosis. They also highlight the importance of functional labs to assess hormones, stress levels, and overall health during perimenopause. Dr. Bahar shares her signature program for menopausal women, which focuses on personalized support, functional tests, and supplements to address individual needs.Join Debi and Dr. Bahar as they shed light on the misconceptions surrounding hormone replacement therapy and emphasize the significance of lifestyle factors, such as stress management, diet, and sleep, in conjunction with hormone therapy for optimal health during perimenopause and beyond.Key  Takeaways:[1:28] Perimenopause and bone loss[3:16] When does perimenopause start[4:47] Early symptoms[6:23] Root causes of symptoms[8:30] Managing the symptoms[10:31] Cortisol [11:19] Functional labs to run and what she finds in them[13:09] Metabolites[14:59] Hormones – prescribing, misinformation, and when to take them[24:20] Her recommendations[25:13] Diet[26:38] Food sensitivities and foods to avoid inflammation[29:43] NutrientsWhere to Find Guest:WebsiteInstagramMemorable Quotes:"It's not jut replacing the hormones but making sure the body is breaking it down and getting rid of the excess." [13:53] - Dr, Bahar "And hormones are critical to bone health." [16:29] Debi  "Hormones are very important and the sooner we start the better outcome with presentation of osteoporosis." [17:35] - Dr. Bahar"Hormones can really be empowering for women in addition to the right lifestyle." [32:18] - DebiTo learn more about me and to stay connected, click on the links below:Instagram: @debirobinsonwellnessWebsite: DebiRobinson.comHealthy Gut Healthy Bones Program

This episode dives into the emerging concept of psychobiotics, exploring how these live (probiotic) microorganisms can positively impact mental health by interacting with the gut-brain axis. We'll provide an in-depth look at the anatomy of the gut lining and the enteric nervous system, explaining how these pathways facilitate communication between the gut and the brain. Additionally, we'll spotlight the psychobiotic Bifidobacterium longum 1714, detailing its mechanisms and benefits for stress and anxiety relief. Topics: 1. General Overview of Psychobiotics - Definition and origin of the term "psychobiotics". - Mental health benefits: alleviating anxiety, depression, enhancing cognitive function, and stress resilience. - Introduction to the gut-brain axis. 2. The Gut-Brain Axis - Detailed explanation of the gut-brain axis. - Overview of the divisions of the nervous system (CNS and PNS). - Further division of the PNS into somatic and autonomic nervous systems. - Division of the autonomic nervous system. - Detailed structure and function of the enteric nervous system (ENS). 3. Gut Lining Anatomy - Layers of the gut lining from the inside out: gut lumen, mucus layers, intestinal epithelium. - Structure and function of the intestinal epithelium and its renewal process. - The role of villi and microvilli in increasing the surface area for nutrient absorption. - Overview of the lamina propria and its immune components. - Overview of the muscularis mucosae 4. Submucosa and Enteric Nervous System (ENS) - Description of the submucosa and its components (blood vessels, lymphatics, nerves). - Detailed structure and function of the submucosal (Meissner's) plexus. - Beyond the submucosa: muscularis externa and the myenteric (Auerbach's) plexus. - Interaction between the ENS and the vagus nerve. 5. Psychobiotics in Action: Bifidobacterium longum 1714 - Introduction to Bifidobacterium longum 1714 and its mental health benefits. - Production of key metabolites (SCFAs, serotonin, GABA) and their roles. - Interaction of metabolites with the ENS and the vagus nerve. - Detailed pathway of signals from the gut to the brain. 6. Other Notable Psychobiotics - Quick overview of other psychobiotics studied for mood regulation: - Lactobacillus rhamnosus GG - Lactobacillus helveticus R0052 - Bifidobacterium breve M-16V - Lactobacillus casei Shirota - Bifidobacterium infantis 35624 - Lactobacillus plantarum PS128 Thank you to our episode sponsor: ⁠⁠Liver Medic⁠⁠⁠ Use code Chloe20 to save 20% on ⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠ ⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠ ⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In this episode Tara breaks down the common arguments for running a DUTCH test and provides her perspective on why it may not be the best investment for those experiencing perimenopausal symptoms. She discusses the limitations of the test in providing root cause answers and highlights the potential need for additional, often costly, tests to address the suggestions raised by the Dutch test results. Tara also discusses the significance of combining the results of Root Tests such as the comprehensive blood work, stool test, and HTMA to provide a more holistic understanding of hormonal imbalance and related health concerns, particularly during perimenopause.   Here's a sneak peek at what you can expect in this episode: 1. Root Cause Analysis: Understand why the Dutch test may not give root cause answers and how it may lead to additional expenses. 2. Metabolites vs. Practical Solutions: Uncover the reality around estrogen metabolites and how lifestyle changes can support pathways highlighted by the Dutch test. 3. Organic Acids and Blood Work Comparison: Explore the comparison between organic acids tests and comprehensive blood work, learning when each may be more beneficial. 4. Deep Dive into Adrenal Health: Gain a new perspective on interpreting cortisol patterns and understanding the importance of nervous system support. 5. The Best Hormone Tests for Perimenopause: Discover practical advice on which hormone tests may be more beneficial during the perimenopausal phase.   Mentioned in this episode: Purchase Herbatonin here and use Tara's discount code for 15% off, which is Tara15: https://symphonynaturalhealth.com/TaraHerbatonin The Hormone Balance Solution - My signature 6-month comprehensive hormonal health program for women in midlife who want to get solid answers to their hormonal health issues once and for all so they can kick the weight gain, moodiness, gut problems, skin issues, period problems, fatigue, overwhelm, insomnia, hair/eyebrow loss, and other symptoms in order to get back to the woman they once were.   You might also enjoy these recent episodes: EPISODE 45: My thoughts on the DUTCH test EPISODE 81: An interview with Deanna Minich, PhD, nutrition scientist, educator, & author about melatonin & its multiple functions, specifically, Herbatonin, which is far superior to other types of melatonin. . Click here to check out HRT Made Simple™     Hi, I'm Tara Thorne, FDN-P, RHN, FNC and women's health and hormone expert. After serving hundreds of women in my signature program, The Hormone Balance Solution, I bring to you, the HBS Podcast. This podcast is all about educating women, and giving them actionable strategies for supporting hormonal harmony. It's my passion to empower women to take back their health and their happiness. We'll cover gut health, mineral balancing, nutrient deficiencies, cellular health, nervous system health, functional testing, and so much more. No Fluff. No BS. Just everything you need to know and nothing you don't.

Prof. J. David Miller has focused his research on mycotoxins and damp buildings and health for the last 40 years first at Agriculture Canada and then at Carleton University in Ottawa. Dr. Miller has published over 370 papers on fungi and fungal toxins and has co-written 10 books on the public health aspects of exposures to fungi and fungal toxins, and has several patents. Miller has served on many national and international committees on the regulation of mycotoxins as well as on mold and dampness in the built environment. This includes on the American Academy of Allergy Asthma & Immunology committee that produced practice parameters for environmental allergens. He was chief editor of the American Industrial Hygiene Association “Green Book” (2008, 2020) and “Field Guide” (1996, 2005) that lay out guidelines for addressing mold and dampness in public buildings. He drafted several chapters of the recent ACGIH Bioaerosols guidelines, second edition. In 2013, Miller was elected as a Fellow of the American Industrial Hygiene Association. In 2021, he received the inaugural Philip R. Morey award from the ACGIH for contributions to bioaerosol guidance.

Dr. Ross Pelton, a renowned expert on the microbiome and Director of Science and Education for Essential Formulas, Inc. discusses the 'oral probiotic dilemma,' highlighting the challenges and misconceptions about probiotics, the importance of dietary fibers and polyphenols, and the role of postbiotic metabolites in health. He details scientific studies demonstrating the benefits of optimizing the gut microbiome and explores Dr. Ohhira's probiotics and their unique fermentation process. The episode also touches on the broader health impacts of a healthy gut microbiome, including its potential in anti-aging, cancer treatment, and overall wellness.

Dr. Hoffman continues his conversation with Ross Pelton, R.Ph., Ph.D., CCN, Science & Education Director for Essential Formulas, makers of Dr. Ohhira's Probiotics.

The GI Research Foundation was able to produce this podcast with sponsorships from AbbVie and Metro Infusion Center.With David T. Rubin, MD, Joseph B. Kirsner Professor of Medicine; and Ashley Sidebottom, PhD, Research Assistant Professor and Platform Director, Host-Microbe Metabolomics Facility, University of ChicagoStruggling with sleep and inflammatory bowel disease (IBD)? You're not alone. This episode dives deep into the surprising connection between sleep, gut health, Crohn's disease and ulcerative colitis. Join us as we chat with world-renowned experts David T. Rubin, MD, and Ashley Sidebottom, PhD who shed light on the intricate relationship between the microbiome, sleep, and IBD:The science behind the gut-sleep connection in IBDHow metabolites can trigger inflammation and sleep disturbancesTo access other episodes of Visceral: Listen to Your Gut and learn more about the GI Research Foundation's support of clinical and laboratory research to treat, prevent, and cure digestive diseases, please visit https://www.giresearchfoundation.org/.Written and produced by Anna Gomberg. Edited and mixed by Mike Collins-Dowden. Available on Apple Podcasts, Spotify, and everywhere else you listen.This episode is brought to you by AbbVie and Metro Infusion Center.AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas. For more information about AbbVie, please visit us at https://www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube, and LinkedInMetro Infectious Disease Consultants, the parent company of Metro Infusion Centers, is proud to announce their 30th anniversary Gala Celebration on October 26 in downtown Chicago. With 110 physicians and over 220 infusion centers nationwide, we are committed to making life saving therapies available in a comfortable and cost-effective environment, while continuing to support the future generations of infectious disease physicians. Please visit us at www.midcgala.com to learn how you can participate.#podcast #research #metabolites #microbiome #sleepstudy #IBS #IBD #crohns #colitis #hope #mindbody #futureofmedicine

Exploring the science behind chromophores, we unravel how these molecular entities selectively absorb specific wavelengths of light and can become "activated." As a result of this photoactivation, chlorophyll metabolites within the human body, when combined with sunlight exposure, MAY, according to several studies, have interesting and profound implications for cellular energy production and longevity. Topics: 1. Introduction to the Topic - Importance of ATP production - When chromophores are stimulated by light? - Accessibility to red light therapy panels - Enhancing sunlight absorption 2. Understanding Chromophores - Definition and function - Molecular structure and electron configuration - Selective absorption of wavelengths - Example: Methylene blue 3. Differentiating Types of Reactions - Focus on chlorophyll metabolites' integration within cells and mitochondria 4. Role of Chlorophyll Metabolites in ATP Production - Overview of ATP production in mitochondria - Interaction of chlorophyll metabolites with CoQ10 - Photoreduction of quinones and, specifically CoQ10 in the electron transport chain 5. Specific Chlorophyll Metabolites and ATP Synthesis - Focus on chlorin p-a - Activation through photon absorption - Review of the mechanism of ATP synthesis stimulation 6. Light Requirements for Chlorophyll Activation - Necessary wavelengths for activation (around 670 nm) - Comparison of red light therapy and natural sunlight - Evidence of chlorophyll activation under sunlight. Is natural sunlight enough to activate the metabolites in this case? 7. Penetration of Light in Biological Tissues - Attenuation of light in human and animal tissues - Penetration depth in various tissues 8. Effects of Chlorophyll on Cellular Biology - Increase in ATP in isolated animal mitochondria - Extension of lifespan in worms (up to 17%) 9. Conclusion and Personal Protocols - Need for further research - Personal supplementation protocols - Personal integration of chlorophyll supplementation with sun exposure for enhanced ATP production. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In this episode of The SIBO Doctor Podcast, Dr. Nirala Jacobi discusses: -  The Gut Microbiome's Role. The gut microbiome's influence on health and disease is significant, with modern lifestyles negatively impacting its state. -  Microbiome Diversity. A diverse microbiome, akin to a healthy ecosystem, is crucial for preventing overgrowth of harmful bacteria and maintaining overall health. - Metabolites. Bacterial genes in the microbiome produce metabolites that can indicate health status and influence mood and energy levels. Restore the Microbiome - New online course: Dr Jacobi's strategies to rewild the microbiome, emphasizing the importance of diversity and the production of beneficial metabolites. Resources mentioned in this podcast: Learn more about the new Restore Your Microbiome course on The SIBO Doctor. Order your Microbiome Insight test from Microba.

Discover the astonishing intricacies of microbial ecosystems and their potential to improve healthcare.  Guest KC Huang is many things: A bioengineer. A microbiologist. An inventor. But mostly he's an expert on the ecology of the human gut. He and his collaborators have developed a device that can sample bacterial DNA and create a living map of the gut microbiome from mouth to … ah, well … you know. Every step of the way, he says, we play host to trillions of guests we know very little about. It's time we got to know them, Huang tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Chapter Timestamps:(00:00:00) IntroductionRuss introduces the gut microbiome and its impact on health. The potential for engineering ourselves through microbiome manipulation.(00:00:57) Overview of Gut MicrobiomeRuss Altman introduces the guest, KC Huang. KC provides an overview of the gut microbiome and its impact on health and everyday life.(00:05:21) Challenges in Studying the Gut MicrobiomeKC Huang discusses the challenges in studying the gut microbiome, including the limited data and the difficulty in accessing the ecosystem.The unique interface between human cells and gut microorganisms is emphasized.(00:07:02) Poop as a Data SourceRuss Altman humorously mentions the collection of poop for research purposes. The difficulties in studying the bowel's internal microbiome are discussed.(00:08:53) Diversity of Gut MicroorganismsKC Huang addresses the diversity of microorganisms in the gut microbiome. The challenges of characterizing the complex ecosystem are highlighted.KC Huang corrects a common misconception about the location of the gut microbiome. The gut microbiome as an external influence on the human body is explained.(00:10:45) The Impact of Gut Microbiome Beyond Bowel MovementsRuss Altman mentions the gut microbiome's influence on brain function, diet, exercise, and more. The far-reaching effects of the gut microbiome are introduced.KC Huang addresses the connection between the gut microbiome and brain function. The constant interaction between microorganisms and the brain is emphasized.(00:12:22) Impact of Gut Microbiome on SleepinessThe relationship between post-meal sleepiness and gut microbiome activity is mentioned. The gut as a source of constant growth and activity is explained.(00:13:19) The Device for Studying the Gut MicrobiomeKC Huang introduces an innovative device designed to study the gut microbiome by collecting samples at different points in the gut. The device's simplicity and capabilities for multi-dimensional analysis are highlighted.(00:17:32) Exercise and Its Effect on Body TemperatureThe role of exercise in increasing body temperature and its potential influence on the gut microbiome is explored. Possible connections between exercise, temperature, and gastrointestinal effects are mentioned.(00:21:55 ) The Student Survey on Microbiome TherapiesKC Huang shares the results of a student survey about microbiome-based therapies, highlighting changes in perception after studying the field. The evolving excitement and uncertainty surrounding the field's future are mentioned.(00:23:52) The Need to Embrace Ecosystem ComplexityKC Huang emphasizes the importance of embracing the complexity of the gut microbiome ecosystem. The limitations of reductionist approaches in the field are highlighted.(00:28:20) Complexity with a Thousand SpeciesKC Huang explores the challenges of dealing with complex microbial ecosystems containing thousands of species. The significance of interactions between these species is discussed.

We welcome back Dr Nicole Rous who previously recorded episode 40 with Pure Animal on Supporting Your Pet's Health with Essential Oils.  Topics discussed in this podcast include: How can disease affect the gut microbiome? How to know if there's dysbiosis present. Dr Nicole shares what she considers when selecting an appropriate probiotic. The importance of prebiotics alongside probiotics. When does Nicole use supplements vs food-based sources. Is it safe to give garlic to your pet? Latest research on antibiotics use for gastrointestinal conditions. Common gastrointestinal symptoms in cats. Effects of probiotics and prebiotics on feline gut health. You can find Dr Nicole Rous at Mont Albert Vet Clinic (www.montalbertvet) or through Shy Tiger (www.shytiger.com.au). Dr Rous in also on Insta @shytigerhealth and @drnicolerous Studies mentioned by Dr Nicole: D'Angelo S et al. Effect of Saccharomyces boulardii in dogs with chronic enteropathies: double-blinded, placebo-controlled study Veterinary Record Dec 2017;10.1136/vr 6  Schmidt M., Unterer S, Suchodolski J. S. et al. The fecal microbiome and metalbome differs between dogs fed Bones and Raw Food (BARF) biets and dogs fed commercial diets.PLOS ONE August 15, 2018 Kwong T. C., Chau E. C. T., Mak M. C. H. et al. Characterization of the Gut Microbiome in Healthy Dogs and Dogs with Diabetes Mellitus. Animals 2023, 13, 2479 Grzeskowiak L., Endo A., Beasley S., Salminen S., Microbiota and probiotics in canine and feline welfare. Elsevier 2015 Aktas M. S., Borku M. K., Ozkanlar Y., Efficacy of Saccharomyces Boulardii as a probiotic in dogs with Lincomycin induced diarrhoea. Bull Vet Inst Pulawy, 365-369, 2007 Li Y., Lei Z., Li Y., Yang M., Yang C., Li L. Effect of a Multistrain Probiotic on Feline Gut Health through the Fecal Microbiota and Its Metabolite SCFAs. Metabolites 2023, 13, 228See omnystudio.com/listener for privacy information.

In this first episode of series 'Whole Body Health', Dr. JP Saleeby explains the importance of the thyroid gland and why it is important to keep it in balance in the body. Watch now. Learn more about 'Whole Body Health' here: https://flccc.net/wholebodyhealth Dr. JP Saleeby | Carolina Holistic Medicine https://carolinaholisticmedicine.com/ Dr. JP Saleeby's Substack | Yusuf's Substack https://jpsaleebymd.substack.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ References: Gong B, Wang C, Meng F, Wang H, Song B, Yang Y, Shan Z. Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2021 Nov 17;12:774362. I, Capriello S, Filardo S, Centanni M, Virili C. Microbiota and Thyroid Disease: An Updated Systematic Review. Adv Exp Med Biol. 2023;1370:125-144. Liu Q, Sun W, Zhang H. Interaction of Gut Microbiota with Endocrine Homeostasis and Thyroid Cancer. Cancers (Basel). 2022 May 27;14(11 ):2656. Liu H, Liu H, Liu C, Shang M, Wei T, Yin P. Gut Microbiome and the Role of Metabolites in the Study of Graves· Disease. Front Mol Biosci. 2022 Feb 16;9:841223. Knezevic J, Starchl C, Tmava Berisha A, Amrein K. Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function? Nutrients. 2020 Jun 12;12(6):1769. Donate to the Front Line Covid-19 Critical Care Alliance: https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html Buy FLCCC gear: https://supportflccc.store/ Subscribe to our mailing list on our website: http://flccc.net/signup Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

There are very few remaining locations on Earth that are untouched by humans, and those that do remain are in very extreme environments that are difficult to access.  However, accessing and studying life in these extreme environments can provide unique insights to the biology of life. Understanding how simple organisms adapt and survive in seemingly unlivable conditions is a unique field of study with the potential to inform and affect the human condition.  We're joined in this episode by Dr. Brandi Kiel Reese and Lydia Hayes-Guastella from the Dauphin Island Sea Lab at the University of South Alabama. They are both geomicrobiologists that study microbial life in extreme environments like the Mariana Trench and Antarctica.  They do an excellent job of painting a picture of how extreme conditions are in these environments and how they manage to collect and preserve samples from such harsh conditions. We learn about the various methods they use to analyze the microbial samples they collect, including the use of digital PCR (dPCR) to detect and quantify transcripts that would otherwise not be detectable given how few cells they're able to collect.   Brandi and Lydia also share their unpredictable career path journeys, while sharing some insights and learnings from their respective experiences. We learn what they each love about their work and what qualities is takes to be successful at what they do. Once again, we're reminded of what a small world it is, especially when you're in a specialty field such as geomicrobiology of extreme environments.   Visit the Absolute Gene-ius page to learn more about the guest, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

Guests: Dr. Lance Baumgard, Iowa State University and Dr. Jim Drackley, University of Illinois at Urbana-ChampaignOur Real Science Exchange pubcast always has leading scientists and industry professionals discussing the latest ideas and trends, and tonight we have two very well-known guests. Dr. Lance Baumgard and Dr. Jim Drackley join us to discuss cow management and the dogma that has developed over the years. Dr. Baumgard kicks off by explaining the dogma of the transition period - two metabolites reduce the animal's immune system and predispose them to health disorders. (5:38) Dr. Drackley continued by saying he was influenced by research that could show in a clinical case of ketosis, there is an underlying subclinical, perhaps inflammatory pressure, causing the problem. (20:39) Dr. Baumgard mentioned utilizing ketones comes at a metabolic disadvantage: a loss of energy. So what could cows be doing if they're able to increase their feed intake enough so they don't have to make ketones? (27:18) Dr. Drackley said the million-dollar question is if inflammation is the key, what do we do about it? How do we prevent it or treat it? (31:38) Dr. Baumgard explained his thought process is that if even healthy cows have some level of immune activation going on in the transition period, some of this subclinical hypocalcemia that's occurring in the transition period could be caused by immune activation. (43:50)Dr. Drackley said as we select for high-milk production, perhaps part of that is enhanced ability to use ketones. The idea of a tenant of high milk production is you've got the time of lower insulin and high growth hormone driving lactation. Those are all tied up with genetic selection.  (46:40) Dr. Baumgard wrapped up by saying from a producer or veterinarian perspective, it's easy to treat and get out, but what really needs to take place is a full examination; where did this immune activation come from? (54:56)Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.  If you want one of our new Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.

As we gain insight into microbiome impact on our health, we need accurate tests that tell us not only what and how much is there, but also which metabolites, or post-biotics created that can have downstream effects. So today I'm thrilled to welcome the brilliant Dr. Erika Ebbel Angle, PhD, biochemist, CEO, and co-founder of Ixcela, to discuss their fingerstick gut microbiome test. We'll discuss the 11 key markers, the value of a blood sample over urine, and the impact of endurance sports and chronic stress on health markers as revealed by the test. We also chat about my own results, how impressed I was by the insight provided – and how they clearly identified changes I could make to improve my markers. Listen and take notes -- I know I did! ~DrKF

This podcast is a commentary and does not contain any copyrighted material of the reference source. We strongly recommend accessing/buying the reference source at the same time. ■Reference Source https://www.ted.com/talks/leila_pirhaji_the_medical_potential_of_ai_and_metabolites ■Post on this topic (You can get FREE learning materials!) https://englist.me/55-academic-words-reference-from-leila-pirhaji-the-medical-potential-of-ai-and-metabolites--ted-talk/ ■Youtube Video https://youtu.be/NLzOPj4DKQg (All Words) https://youtu.be/9NftP5ZHXWk (Advanced Words) https://youtu.be/urbD19OJ_YA (Quick Look) ■Top Page for Further Materials https://englist.me/ ■SNS (Please follow!)

In this episode of Your Infinite Health, LeNae and Dr. Trip addresses some of the most common myths surrounding testosterone, especially the one about it causing heart attacks.Testosterone is a hormone that has been the subject of much discussion and debate in recent years, with many claims being made about its potential benefits and drawbacks. In particular, the idea that testosterone causes heart attacks has become a widespread myth, one that needs to be corrected.It's important to understand that testosterone requirements are not the same for everyone and may be affected by age, physical activity, and other factors. And while engaging in exercise can increase testosterone consumption, it is not a cause of heart disease. On the contrary, testosterone has been found to play a role in preventing cardiovascular disease, dementia, and diabetes.For anyone considering testosterone therapy, it's important to understand that regular monitoring and follow-up are essential for achieving optimal results. It's also important to be aware that other hormones and metabolites can affect testosterone's effectiveness, and that some people may require higher levels of testosterone due to impaired androgen receptors.While testosterone replacement therapy can help optimize cholesterol levels over time, it's also possible to experience excessive levels of testosterone, leading to synthetic androgen stimulation. Women, in particular, may experience side effects such as changes in voice and hair growth, while men may experience excessive levels of testosterone as well.Ultimately, maintaining an optimal testosterone level can have a wide range of benefits, ranging from improved focus and stamina to reduced risk of cardiovascular disease. In order to achieve these benefits, it's important to work closely with a physician, undergo regular check-ins, and have an understanding of what optimal testosterone levels are for you.Dr. Trip Goolsby & LeNae Goolsby are the co-founders of the Infinite Health Integrative Medicine Center, and are also the co-authors of the book “Think and Live Longer”.TakeawaysTestosterone requirements vary depending on age.Testosterone is not the cause of heart attacks.Do regular lab tests with your physician.ConnectDr. Trip Goolsby & LeNae Goolsby are the co-founders of the Infinite Health Integrative Medicine Center, and are also the co-authors of the book “Think and Live Longer”.

Sign up to get exclusive first access to the RP Hypertrophy App: https://bit.ly/401aAt4   0:00 Intro 1:02 Simplifying muscle building 3:27 SRA explained 4:36 Stimulators of hypertrophy explained 11:01 Tension  15:25 Lifting too light or heavy 20:28 Repetition Ranges  23:46 Using bands on machines 25:48 Lengthen Partials explained 30:38 Metabolites 32:52 The pump 34:47 Jacked guys not using full ROM 38:10 Damage

Older employees are worried about their finances, and planning to continue working longer than intended.  An AHIP survey reports an increase in Medicare supplement sales. They promote Medicare Advantage plans so it must be true! Work is being done to develop urine tests that will detect certain types of cancer. Metabolites in the urine will provide the markers.  Contact me at: DBJ@MLMMailbag.com (Most severe critic: A+)   Inspired by: "MEDICARE FOR THE LAZY MAN 2023; Simplest & Easiest Guide Ever!" on Amazon.com. Return to leave a short customer review & help future readers. Official website: https://www.MedicareForTheLazyMan.com

In this week's episode of ReInvent Healthcare, we go over different adrenal testing options, what sets them apart, and why they are important. Having different options is good for you and your clients to know so that they are aware of their options and how each test works.    IN THIS EPISODE: Blood Chemistry Adrenal Tests There are several markers of electrolyte balance on the blood chemistry that give clues about the status of the adrenals.  Testing cortisol in the morning is not sufficient since cortisol has its own circadian rhythm. For blood tests of cortisol to be useful it would need to be done 4 times a day. Salivary Adrenal Tests These types of tests should also be done 4-5 times a day. This test also looks at DHEA and we want to look at the sum of the Cortisol in a 24-hour period. Again, there is also a pattern to this type of test that we should be aware of since it can be a telling clue about the adrenal state. The DUTCH Test or the Dried Urine Test for Comprehensive Hormones This is the test that I use most and there are different versions of DUTCH Tests with different purposes that can check the adrenals, sex hormones, and also the cortisol awakening response. Additionally it tests for cortisol metabolites.  What are Metabolites? When cortisol is broken down for excretion, it is converted into cortisol metabolites. When we look at metabolites we are assessing the body's ability to clear cortisol, which gives us clues about other hormone and body system functions.   RESOURCES: Read through our FREE Resource Adrenal Guide. Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease.  Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training.   Watch our recorded Thyroid Adrenal Workshop here.  

In this week's episode of ReInvent Healthcare, we go over different adrenal testing options, what sets them apart, and why they are important. Having different options is good for you and your clients to know so that they are aware of their options and how each test works. IN THIS EPISODE:Blood Chemistry Adrenal TestsThere are several markers of electrolyte balance on the blood chemistry that give clues about the status of the adrenals. Testing cortisol in the morning is not sufficient since cortisol has its own circadian rhythm. For blood tests of cortisol to be useful it would need to be done 4 times a day.Salivary Adrenal TestsThese types of tests should also be done 4-5 times a day. This test also looks at DHEA and we want to look at the sum of the Cortisol in a 24-hour period. Again, there is also a pattern to this type of test that we should be aware of since it can be a telling clue about the adrenal state. The DUTCH Test or the Dried Urine Test for Comprehensive HormonesThis is the test that I use most and there are different versions of DUTCH Tests with different purposes that can check the adrenals, sex hormones, and also the cortisol awakening response. Additionally it tests for cortisol metabolites. What are Metabolites?When cortisol is broken down for excretion, it is converted into cortisol metabolites. When we look at metabolites we are assessing the body's ability to clear cortisol, which gives us clues about other hormone and body system functions, RESOURCES:Read through our FREE Resource Adrenal Guide.Get our FREE Guide to Taking a Detailed Health History that gets you to root causes with ease. Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training. Watch our recorded Thyroid Adrenal Workshop here.

Our gut microbiome (that's all the microorganisms - such as bacteria, viruses and fungi - living in our gut) is really important for healthy digestion. But did you know that it's also linked to our mental health? In this episode of the Big Questions Podcast we chat to neuroscientist Prof Philip Burnet from Oxford's Department of Psychiatry about how our gut is connected to our brain, and how taking prebiotic and probiotic supplements could even help in the treatment of mood and psychotic disorders.

Dr. Nora Franceschini and Ms. Kaylia Reynolds summarize the findings of their study "Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population," on behalf of their colleagues.

As technology evolves, so too does our understanding of the gut microbiome. Until now, we've only seen the tip of the iceberg. Metagenomics offers us the ability to assess the complete microbiome as well as its potential function. This is the technology that powers Genova's new Microbiomix stool profile and we've partnered with Microba Life Sciences – a world leader in microbiome metagenomic analysis based in Australia. As Microba's Clinical Solutions Manager, Dr. Ken McGrath combines his expertise in molecular genomics with the clinical application of this technology. Today, we speak with an industry-leading expert in microbiome research, Dr. Ken McGrath, who explains all things metagenomics, and what we're now learning (and unlearning) about the gut microbiome. Today on The Lab Report: 3:15 Meet Dr. Ken McGrath 8:15 16s vs. whole genome sequencing metagenomics 16:20 Taxonomy and continually changing organism names 26:20 Microbes vs. Metabolites – total paradigm shift 32:00 Is Dysbiosis even a thing!? 33:45 Parasites, Yeast, and Metagenomics 39:20 Human genomics vs. bacterial genomics 45:30 Global microbiome differences 51:50 The Fireball(s) Additional Resources: Microba Genova's Microbiomix Profile Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week's episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don't forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.

VIDEOS: The Cost of Denial Clip (17:33) Hang On, Bill Gates and Dr. Fauci just did WHAT? | Redacted with Clayton Morris (21:43) There is nothing constructive about the pot calling the kettle black. – Clare Daly  (1:17) Clinical trial for nicotinamide riboside: Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits University of Iowa Health Care, October 10, 2022 In a clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite — known as NAD+ — can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline. These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone many clinical trials to see if they work in people. The new research, reported in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses. “This trial shows that oral NR safely boosts human NAD+ metabolism,” Brenner says. “We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely.” Consumption of a bioactive compound from Neem plant could significantly suppress development of prostate cancer National University of Singapore, September 29, 2022 Oral administration of nimbolide, over 12 weeks shows reduction of prostate tumor size by up to 70 per cent and decrease in tumor metastasis by up to 50 per cent A team of international researchers led by Associate Professor Gautam Sethi from the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore (NUS) has found that nimbolide, a bioactive terpenoid compound derived from Azadirachta indica or more commonly known as the neem plant or curry leaf common in throughout Indian cuisine, could reduce the size of prostate tumor by up to 70 per cent and suppress its spread or metastasis by half. In this research, we have demonstrated that nimbolide can inhibit tumor cell viability — a cellular process that directly affects the ability of a cell to proliferate, grow, divide, or repair damaged cell components — and induce programmed cell death in prostate cancer cells,” said Assoc Prof Sethi. The researchers observed that upon the 12 weeks of administering nimbolide, the size of prostate cancer tumor was reduced by as much as 70 per cent and its metastasis decreased by about 50 per cent, without exhibiting any significant adverse effects. “This is possible because a direct target of nimbolide in prostate cancer is glutathione reductase, an enzyme which is responsible for maintaining the antioxidant system that regulates the STAT3 gene in the body. The activation of the STAT3 gene has been reported to contribute to prostate tumor growth and metastasis,” explained Assoc Prof Sethi. “We have found that nimbolide can substantially inhibit STAT3 activation and thereby abrogating the growth and metastasis of prostate tumor,” he added. Mindfulness training provides a natural high, study finds University of Utah, October 20, 2022 New research from the University of Utah finds that a mindfulness meditation practice can produce a healthy altered state of consciousness in the treatment of individuals with addictive behaviors. Not unlike what one might experience under the influence of psychedelic drugs—achieving this altered state through mindful meditation has the potential lifesaving benefit of decreasing one's addictive behaviors by promoting healthy changes to the brain. The findings come from the largest neuroscience study to date on mindfulness as a treatment for addiction. The study, published in the journal Science Advances, provides new insight into the neurobiological mechanisms by which mindfulness treats addiction. Study findings provide a promising, safe and accessible treatment option for the more than 9 million Americans misusing opioids. Eric Garland is the lead author of the paper and is a distinguished professor and directs the University of Utah's Center on Mindfulness and Integrative Health Intervention Development. Garland's study builds on previous research measuring the positive effects of theta waves in the human brain. Researchers have found that individuals with low theta waves tend to experience a wandering mind, trouble concentrating or they ruminate on thoughts about themselves. Low theta waves result in a loss of self-control as the brain slips into its default mode of automatic habits. In contrast, when a person is focused, present and fully absorbed in a task, EEG scans will show increased frontal midline theta wave activity. “With high theta activity, your mind becomes very quiet, you focus less on yourself and become so deeply absorbed in what you are doing that the boundary between yourself and the thing you are focusing on starts to fade away. You lose yourself in what you are doing,” said Garland. Garland's new study showed it is in this mindful, theta wave state that people begin to experience feelings of self-transcendence and bliss, and the brain changes in ways that actually reduce one's addictive behaviors. Garland's research team recruited 165 adults with long-term opioid use for the study. Participants were randomly placed into either the control group that participated in supportive group psychotherapy or the experimental group taught to incorporate Mindfulness-Oriented Recovery Enhancement (MORE) into their daily lives. Participants showed more than twice as much frontal midline theta brain activity following treatment with MORE, whereas those in supportive therapy showed no increase in theta. Participants in MORE who showed the biggest increases in theta waves reported more intense experiences of self-transcendence during meditation, including the sense of one's ego fading away, a sense of oneness with the universe or feelings of blissful energy and love. MORE also led to significant decreases in opioid misuse through the nine-month follow-up. These reductions in opioid misuse were caused in part by the increases in frontal midline theta brain waves. Garland explained that by achieving “tastes of self-transcendence” through meditation, mindfulness therapy boosted theta waves in the frontal lobes of the brain to help participants gain self-control over their addictive behaviors. Free radicals blamed for toxic buildup in Alzheimer's brains Rutgers University, October 11, 2022. A study reported in Cell Death & Disease revealed a previously unknown mechanism that may contribute to traumatic brain injury and Alzheimer's disease. While a buildup of the protein amyloid-beta has been hypothesized to be the major driver of Alzheimer's disease, the study suggests that another protein, after undergoing oxidation by free radicals, could be a causative factor. “Indeed, scientists have known for a long time that during aging or in neurodegenerative disease cells produce free radicals,” explained lead researcher Federico Sesti, who is a professor of neuroscience and cell biology at Rutgers Robert Wood Johnson Medical School. “Free radicals are toxic molecules that can cause a reaction that results in lost electrons in important cellular components, including the channels.” Dr Sesti and colleagues determined that oxidation of a potassium channel known as KCNB1 results in a toxic buildup of this protein, leading to increased amyloid-beta production and damage to brain function. “The discovery of KCNB1's oxidation/build-up was found through observation of both mouse and human brains, which is significant as most scientific studies do not usually go beyond observing animals,” Dr Sesti reported. “Further, KCBB1 channels may not only contribute to Alzheimer's but also to other conditions of stress as it was found in a recent study that they are formed following brain trauma.” Study: Maternal, paternal exercise affects metabolic health in offspring Ohio State University, October 19, 2022 A mouse study by Kristin Stanford, with The Ohio State University College of Medicine at the Wexner Medical Center, provides new ways to determine how maternal and paternal exercise improve metabolic health of offspring. This study used mice to evaluate how their lifestyles—eating fatty foods vs. healthy and exercising vs. not—affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. This process, called metabolism, makes energy and the materials needed for growth, reproduction and maintaining health. Metabolites can serve as disease markers, particularly for type 2 diabetes and cardiovascular disease. “Tissue metabolites contribute to overall metabolism, including glucose or fatty acid metabolism, and thus systemic metabolism. We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated. This new data contributes to how maternal or paternal exercise could improve metabolism in offspring,” Stanford said. This study found that all forms of parental exercise improved whole-body glucose metabolism in offspring as adults, and metabolomics profiling of offspring serum, muscle, and liver reveal that parental exercise results in extensive effects across all classes of metabolites in all of these offspring tissues. Regular consumption of fried food before pregnancy increases risk of developing gestational diabetes Kennedy Shriver National Institute of Child Health and Human Development, October 10, 2022 New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that women who eat fried food regularly before conceiving are at increased risk of developing gestational diabetes during pregnancy. Gestational diabetes (GDM) is a complication that can arise during pregnancy, and is characterised by abnormally high blood glucose during the pregnancy (especially in the final 3 months). It can lead to increased birthweight of the child, as well jaundice and other complications. When left untreated, it can cause complications or stillbirth. Women who have GDM are more likely to later develop full blown type 2 diabetes. The authors included 21,079 singleton pregnancies from 15,027 women in the Nurses' Health Study II (NHS II) cohort. NHS II is an ongoing prospective cohort study of 116,671 female nurses in the USA aged 25-44 years at the start of study. For fried food consumption, participants were asked “how often do you eat fried food away from home (e.g. French fries, fried chicken, fried fish)?” and “how often do you eat food that is fried at home?” Both questions had four possible frequency responses: less than once per week, 1-3 times per week, 4-6 times per week, or daily. The researchers analysed fried food consumption at home and away from home separately, as well as total fried food consumption. In addition, they asked the participants what kind of frying fat/oils they usually used at home, with the possible responses as follows: real butter, margarine, vegetable oil, vegetable shortening, or lard. The association persisted after further adjustments were made for varying body-mass index (BMI). After this, the risk ratios of GDM among women who consumed total fried foods 1-3, 4-6, and 7 or more times per week, compared with those who consumed less than once per week, were 1.06, 1.14, and 1.88 respectively (thus an 88% increased risk for 7 or more times per week compared with less than once per week). The authors say: “The potential detrimental effects of fried food consumption on GDM risk may result from the modification of foods and frying medium and generation of harmful by-products during the frying process. Frying deteriorates oils through the processes of oxidation and hydrogenation, leading to an increase in the absorption of oil degradation products by the foods being fried, and also a loss of unsaturated fatty acids such as linoleic and linolenic acids and an increase in the corresponding trans fatty acids such as trans-linoleic acids and trans-linolenic acids.” They add: “Frying also results in significantly higher levels of dietary advanced glycation end products (AGEs), the derivatives of glucose-protein or glucose-lipid interactions. Recently, AGEs have been implicated in insulin resistance, pancreatic beta-cell damage, and diabetes, partly because they promote oxidative stress and inflammation. Moreover, intervention studies with a diet low in AGEs have shown significantly improved insulin sensitivity, reduced oxidant stress, and alleviated inflammation.” When analysed separately, the authors found that there was a statistically significant association of GDM with fried food consumption away from home, but not with fried food consumption at home. The authors say: “Deterioration of oils during frying is more profound when the oils are reused, a practice more common away from home than at home. This may partly explain why we observed a stronger association of GDM risk with fried foods consumed away from home than fried foods consumed at home.”

In this weeks episode of the microbe moment, Jon talks to Dr. Devlin, an associate professor at Harvard medical school. We talk about how her lab researches the gut microbiome, the particular chemicals, including steroids and sterols that the gut bacteria metabolize and how they affect the body, the actions of bile salt hydrolase on bile acids, and compounds that can inhibit some of these enzymes. You can find out more about Dr. Devlin's research on twitter @DevlinLab or by visiting the labs website here.  Thanks to our sponsor Zymo Research. you can find out more about the company and their products here.  Visit our website at microbigals.com where we are updating with new content, including blog posts, regularly. you can also find us on twitter @MicrobiGals. Also, if you would like to donate to our show, we have started a kofi page. you can donate on our website or visit https://ko-fi.com/microbigals.  

In this episode of Fitness Disrupted 2.0 Tom looks at recent research into how our diets potentially affect our cognitive health. 

In this episode, we discuss how to assess mitochondrial dysfunction and energy metabolism by using a test called the Organic Acid Test with returning guest, Lisa Fouladi. Lisa is a functional nutritionist and an eternal student with an insatiable appetite for nutritional information. Tune in as Lisa explains what the Organic Acid Test is, how to use it as a practitioner and when to request it for your clients and patients. As you become proficient at using these tests to help you pinpoint imbalances, you're going to help people who haven't been able to receive this kind of help from other practitioners.    IN THIS EPISODE:     [02:30] What is the Organic Acid Test?   [07:30] How to use the Organic Acid Test to assess mitochondrial function.  [18:30] When is the right to do an Organic Acid Test for your client?   [25:00] What else to look at on the Organic Acid Test that helps enhance and improve energy metabolism.  [30:00] Focusing on biochemistry as a practitioner can be extremely helpful in finding the best results for your clients.   [32:50] Learning how to do functional tests will add to your success as a health practitioner.     KEY TAKEAWAYS:    Organic Acid Tests bring biochemical pathways to life and help connect the dots. Instead of directly measuring nutrient concentrations, abnormal concentrations of organic acids provide functional markers for the metabolic effects of micronutrient inadequacies.  Organic acid testing pairs well with other types of testing, like blood work and even genetic testing. By correcting or addressing these imbalances, we help the body's ability to heal and stay healthy.  As a practitioner, it's crucial to know how to do functional tests as part of your success and your clients' success.    RESOURCES:    Strategies For Enhancing Energy Metabolism    Lisa's Website    BIO:  Lisa Fouladi is a functional nutritionist. She helps clients to break free from low energy, pain, and long-term health and weight issues so that they can enjoy the freedom that good and vibrant health provides – she feels she has the best job in the World!    Lisa is committed to achieving breakthroughs for each of her clients. What this means is that she listens and watches summits, conferences, and webinars, gets lost on Pubmed doing research on client health and nutrition issues, binge reads health, nutrition, and food blogs, journal articles from various scholarly academic journals, and pours this information into practical action plans for her clients so they achieve the health and energy of their dreams.    She is an eternal student (aka mega nutrition nerd), and has an insatiable curiosity to use this information to help people. Lisa's approach is unique and science-based, integrating the disciplines of Clinical Nutrition, Nutritional Therapy, Integrative and Functional Nutrition, and Coaching to uncover the root causes and systemic imbalances of health issues. 

Wine is a product of nature, human intervention, chemistry, and it's subject to many outside influences – storage, transport, handling – that can do a number on what's inside the bottle. In this episode, we cover the main things that could go wrong with wine, how they got there, and what to do about it (where possible)! Photo: Pixabay Shout out to Jamie Goode, the outstanding scientist and wine writer who makes so many complex science concepts so easy to understand. Here is the link to his book, “The Science of Wine from Vine to Glass,” from which some of the reference materials for the pod were taken. Also to “Sotheby's Wine Encyclopedia,” who (always with the humor of Tom Stevenson) brings up a number of very real faults that a lot of the mainstream wine press forget to mention (sauerkraut, anyone?). Other sources are below!   Here are the show notes: We start with defining what a flaw is in a wine, versus a taint, as defined by Jamie Goode. Then we talk about just plain old sucky wine. Flaw v Taint: Flaw is endemic to the wine, it happened in winemaking or vineyard Taint is from outside winemaking, like from packaging or from the winery We discuss the Japanese concept that talks about how small flaws can accentuate beauty (it is called Wabi-Sabi, the art of imperfection). Not all technical flaws are bad!     NOT FLAWS: Next we tackle things that need to be dealt with, but aren't flaws or taints: Sediment: What is it? Tannin chains combining and falling out of solution. Looks like your coffee filter threw up or there are brown flakes in the wine. What do you do? Decant, get a filter Sediment on a glass from Canva Images Cork floating in your wine: What is it? User error or an old cork. If you break the cork when you take it out, it may drop some flakes into the wine. If it's an old cork, this is even more likely! What do you do? Fish it out with you finger, a spoon, or get a filter Film/oily looking stuff on the surface: What is it? Most likely it's dishwashing soap residue from either glasses or decanter What do you do? Clean your glasses of the residue, send the glass back if you're in a restaurant. At home, warm water is often good enough to clean wine glasses as long as you have a good brush   Bubblegum, pear drop, nail-polish like aromas: What is it? These aromas come from carbonic maceration, a red winemaking technique where the winemaker ferments the grapes with no oxygen or yeast. Instead they use carbon dioxide to promote the conversion of sugar and malic acid to alcohol. Byproducts of this process are these aromas, and more to boot. Overly cool fermentations can also cause these types of aromas. What do you do? If you hate this, chuck the bottle or give it away and remember you don't like wines made with carbonic maceration. Never buy Beaujolais Nouveau! Tartrate crystals: What is it? Crystals appear either on the side of the cork that was in contact with the wine or, often, at the bottom of the glass in white wines. Tartaric acid was not fined, filtered or stabilized out so tartaric acid crystals formed and the wine cleaned itself up naturally! What do you do? Dare I say it again? Get a filter and get them out if they are in your wine. If they are on the cork, admire how pretty they are and enjoy the wine. Earthiness, green pepper notes: What is it? Just normal wine flavors. The earthiness could be from terroir or it could be the grape. Green pepper is from a compound called methoxypyrazine that is common in Cabernet Sauvignon and its parents, Cabernet Franc and Sauvignon Blanc What do you do? If you love it, drink wines with those profiles. If not, there are plenty of wines without these characteristics Before getting into the major faults, I discuss one that is on the line: Cloudy/Hazy wine: If it's not sediment causing the problem, it could be protein. It may settle out or it may just be part of the wine. Natural wines and unfiltered wines have haze often. Just proceed with caution if you see it. It could be fine or indicate a flaw to come.     Then we hit the hard-core flaws   1. Cork taint What is it? It comes across as musty, wet dog, wet wool, cardboard or, at lower levels, as a wine with acidity and bitterness but no fruit flavor. It is caused by a molecule called TCA, which lives in the pockets of corks but also barrels, cardboard, wood cases, and corks (so yes, screw cap wines can have taint!)   What do you do? About 1-3 bottles in 100 have TCA taint, since cork is better chosen and sanitized now. People also use cork alternatives – plastic corks, screw caps, etc, but event those aren't foolproof. If you get a corked wine, return it. There's no fixing it (although occasionally if the wine is just musty, a good swirl and some time will bring it back)   Photo: Pexels    2. Oxidation What is it? When too much oxygen enters the wine in production, bottling, or storage (the cork or screw cap wasn't affixed properly), the wine can be exposed to too much oxygen. Oxygen is important to making a wine taste great when it's in your glass but if it has too much oxygen before you are ready to drink it, it can make white wines a little brown/tawny, reds a little orange/brown. They will have Sherry-like notes, which shouldn't be there and they will acquire nutty, smelly caramel notes in reds or, if it occurs with Volatile Acidity – vinegar notes. Oxidized wine can also be flat in flavor and aroma   What do you do? If it tastes ok to you, drink it! It won't get better so if you hate it and it's oxidized, bring it back       3. Volatile acidity (VA) What is it? When acetic acid or lactic bacteria is present on the grapes or in the winemaking and has these substances have sufficient oxygen to grow, the wine will taste like vinegar, or nail polish remover. At low levels, VA can present savory and sweet notes that taste good, but at high levels the wine is undrinkable. What do you do? Bring it back for an exchange or refund     5. Reduction/sulfur issues What is it? If you make wine in a reductive fashion – with very little oxygen and utilize too much sulfur, things can go wrong. Yeast make volatile sulfur compounds and things go bad quickly. Hopefully the winemaker catches it before bottling. If not, your wine will smell like burnt rubber, skunk, onion, garlic, rotten eggs, and smelly drains. These are ethyl mercaptans and they are so gross.   What do you do? If any of the above listed smells are in your wine, return it. There is one related thing, however, that may be ok: the smell of matchstick or flint. You may find those aromas in wines that have been made in a reductive fashion. If you swirl or aerate the wine, it will blow off. If your wine has a struck match aroma, rather than a burnt one, give it a few minutes before you issue a verdict and return it.   Reductive wines can smell like skunk!  Photo: Pixabay   5. Maderized wine What is it? The wine has been cooked from poor storage or transport. Often these wines are also oxidized (bonus!). They taste like stewed fruit, burnt caramel, and jam. If you look at cork you may see wine leaking out, and when you remove the cork, there is often wine up and down the sides   What do you do? The wine is toast. You can't save it, so return it.     6. Bubbles in a still wine: What is it? Carbon dioxide has infiltrated the wine. It could be added for texture and style fizz like in Vinho Verde, some Austrian and German wines. OR, and this is the flaw, the wine was bottles with too much residual sugar after fermentation, and yeast were still alive. That fizz is an unplanned secondary fermentation happening in the bottle: re-fermentation has started   What do you do? If it's intentional, it's great. You can swirl to get the bubbles out and that sometimes works if you don't like seeing bubbles (or you can just make peace with them)! If it's frothy from secondary fermentation – it's spoiled, bring it back to the shop.       7. Lightstrike What is it? Ultraviolet (UV) and blue rays from artificial lights and the sun break up amino acids in wine and cause it to stink like cabbage, cauliflower, farmyard/poo skunk, and cardboard. This fault happens most often with whites and wine in clear bottles. According to San Francisco retailer J.J. Buckley, clear bottles block only 10% of light, amber bottles block 90% of light, and green bottles block 50% of light. That means whites and rosés in clear bottles are especially susceptible.   What do you do? The bottle is ruined, return it Cabbage smelling wine is often from Lightstrike Photo: Pixabay    8. Brettanomyces: What is it? Metabolites produced by yeast called Brettanomyces bruxellensis – (shortened to brett in wine parlance), wait around until AFTER fermentation, then they consume the residual sugar saccharomyces cerevisiae (normal yeast) have left. The byproducts are flavor chemicals that can lead to manure, horse saddle, band aid, medicinal, and metallic notes. This happens mostly in red wines, as white wines have acidity to protect them.   What do you do? How you view the wine is really based on taste. Flavors vary based on the strain of brett, and the level of it in the wine. At low levels it adds gaminess, earthiness, spice, and savory notes to the wine. It can be hard to pinpoint in a wine. If you like these types of flavors, you likely enjoy brett. If not, stick with more New World wines from larger wineries, as they really try to eliminate all traces of the metabolite!     9. Mousy What is it? In wines without sulfite protection, mainly natural wines these days, the wine has a few molecules that smell like a mouse or mouse pee. The wine can seem fine when you open it but then the aroma and flavor can appear as the wine is in the glass. Often it just stinks right from the get-go   What do you do? Sensitivity varies. Some people hate it, some are ok with it. Some can really detect it, others don't notice it. Again, it's down to personal choice whether or not you return the wine for the flaw or accept and like it.   10. Smoke taint Fires in California have caused smoke taint. Photo: Unsplash   What is it? A direct result of nearby wildfires. According to Australian research, grapes are most susceptible to smoke, ash, ashtray, singed, and cured meat notes if fires are near the grapes from the period after veraison (when grapes change color, the last stage of ripening) through harvest. Flavor compounds permeate the skins, especially and the result is red wines that are nearly impossible to save. Whites from wildfire vintages are usually ok, as there is no skin contact necessary and the pulp is protected by the skins, but red wines can't be fixed without affecting wine quality, for now.   What do you do? For now, there is no solution to smoke taint. If you see a wine is from a vintage and an area that had wildfires, caveat emptor. Some wineries will release a wine even if it's like choking on an ashtray. Better to stick with whites from the area, if you can.    _______________________________ Other stuff not always on the taint list!   Soapiness: Happens when acids produced by yeast are like salts: Caprylic acid salt (decanoic acid), and leave a soapy taste especially in white wines. They smell like soap but are fruitier. This note is common in high-alcohol wines. (Source: the "Le Nez Du Vin" wine faults kit and Sotheby's Wine Encyclopedia). Like everything, a small amount is tolerable, a larger amount is a fault (and of course, make sure that soapiness isn't from actual soap, as previously mentioned) Soapiness is a fault in a wine!    Cheese: If it's subtle or in an old Riesling, cheese notes are usually good and integrate with the wine's flavors. If it's more like stinky cheese, it's from ethyl butryrate and the wine is done: Take it back     Geranium notes in sweet wines are from sorbic acid or the degradation of geraniol aromas. It is considered a flaw, as are the phenol off-flavors of Carnation notes. Whether or not you like the wine is a matter of taste, but in high concentrations, it is gross and a flaw.   Sauerkraut notes are a bridge too far beyond sour milk or sour cream and are from too much bacteria in the malolactic fermentation. Yuck! This is a definite return to the shop!     This is by no means a total and complete list, but we did the best we can and hopefully it will help you ID what is a flawed or tainted wine and what is just a wine that is poorly made and bad.   _______________________________________________________________ Thanks to our sponsors this week:  Wine Spies uncovers incredible wines at unreal prices - on Zinfandel, Barolo, Champagne...you name it - up to 75% off! It's not a club and there's no obligation to buy. They have a build-a-case option, so you can mix and match wines while enjoying free shipping on every purchase. Visit www.winespies.com/normal you'll get $10 credit to use on your first order! Check them out today!   If you think our podcast is worth the price of a bottle or two of wine a year, please become a member of Patreon... you'll get even more great content, live interactions and classes!  www.patreon.com/winefornormalpeople   To register for an AWESOME, LIVE WFNP class with Elizabeth go to: www.winefornormalpeople.com/classes

In this episode of Root of the Cause Radio, I'll be covering the good, the bad and the ugly of estrogen metabolites: the more benign 2-Hydroxyestrone, the duality of the 16-Hydroxyestrone and the dreaded 4-Hydroxyestrone. 1:53 - Phase 1 estrogen detoxification and estrogen metabolites 2:47 - 16-Hydroxyestrone, the impact, risk and reasons for high levels and the possible downsides of very low levels 4:06 - Can Estriol convert into anything harmful or helpful? 5:40 - The bad and ugly of the 4-Hydroxyestrone and how methylation plays a critical role 7:42 - Phosphatidylcholine and how it can indirectly help to neutralize the 4-Hydroxyestrone metabolite 9:23 - What happens to the 4-Hydroxyestrones that don't get methylated? Hint: DNA damage 9:42 - How sulforaphane stimulates glutathione S transferase and quinone reductase to mop up DNA damaging quinones 11:12 - Can you measure quinone levels? Can you measure DNA damage from oxidative stress (8-hydroxy-2-deoxyguanosine)? 12:00 - How glutathione is made and the critical nutrients necessary 13:49 - How glutathione and sulforaphane impact estrogen metabolites that don't get methylated

This episode was originally released on January 19, 2021. Microbiome, microbes, microorganisms – these terms may be confusing, but the types of bacteria living in and on our bodies can impact arthritis. Learn what helps or harms the microbiome and the health of your gut and discover dietary changes that can make a difference. Visit the Live Yes! With Arthritis Podcast site to read the blog and get show notes and a full transcript: https://arthritis.org/liveyes/podcast We want to hear from you. Tell us what you think about the Live Yes! With Arthritis Podcast. Get started by emailing podcast@arthritis.org. Special Guests: Arthur Kavanaugh, MD and Monica Guma, MD.

An interview with a great naturopathic physician and friend. Dr. Warren Brown, NMD. Dr. Brown has worked with athletes at every level.    Dr. Brown developed his unique clinical program, Clinical Advances for Sport, to optimize the six areas that make up the matrix of health and performance.    Dr. Brown believes that when you discover your hidden physiologic barriers with advanced, specialized testing, then you can give your body what it needs to rise to the top.    Dr. Brown earned his undergraduate degree from Kennesaw State University and his doctorate degree from The School of Naturopathic Medicine at Bastyr University in Seattle, Washington. He completed his clinical rotations at the Bastyr Center for Natural Health and several other clinics throughout the state of Washington. He then went on to complete an 18-month clinical residency program in Tacoma, Washington, during which he also worked with the medical staff for the Seattle Sounders U-23 soccer team.   Dr. Brown has also completed additional coursework in functional medicine and has lectured at functional and integrative medicine conferences across the United States on the topic of laboratory testing. He has also served as a contributor to the 5th Edition of the Textbook of Natural Medicine.   Since 2012, Dr. Brown has been helping athletes and active individuals to reach their highest levels of health and performance through his advanced clinical approach. He has also served in a consultant role for medical staff members of several professional sports teams and is currently writing his first book on naturopathic sports medicine.   Dr. Brown is a member of the American College of Sports Medicine and the Georgia Association of Naturopathic Physicians. He holds a naturopathic physician license in Arizona, United States.   Dr. Warren Brown's website I Clinical Advances for Sport Dr. Warren Brown on Twitter I https://twitter.com/docwb Dr. Brown on LinkedIn I https://www.linkedin.com/in/warren-brown-nmd/

What is in the This Week in Science Podcast? This Week: Cancer Remission, We're in the bad place, Noise pollution, Marsbucha, Rock on!!!, Zinc Poles, Ladies, always ask about your birth control, Ugly fish, Kelp, Otters, Conservatives die sooner, Welfare, Metabolites, Fungal Vision, Fungeyes, No Pole Swap?, And Much More… Become a Patron! Check out […] The post 8 June, 2022 – Episode 879 – Oceans of Science on Ocean Day appeared first on This Week in Science - The Kickass Science Podcast.

SHR # 2842:: Scientists Identify Gut-derived Metabolites that Play a Role in Neurodegeneration plus Sun Damage - Copper peptides Can Repair and Protect - Professor Patrizia Casaccia,PHD - Debbi Barber - Dr. Suzanne Turner, MD - A New York-based, multi-institutional research team has found high levels of three toxic metabolites produced by gut bacteria in the cerebrospinal fluid and plasma samples of multiple sclerosis (MS) patients. The important findings, published in the journal Brain, further scientists' understanding of how gut bacteria can impact the course of neurological diseases by producing compounds that are toxic to nerve cells. PLUS Sun exposure is an important factor in health. But modern culture says avoid the sun as it ages skin prematurely. What's a person to do? We have the answer.