Podcasts about ketamines

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.05.519102v1?rss=1 Authors: Zaytseva, A., Bouckova, E., Wiles, M. J., Wustrau, M. H., Schmidt, I. G., Mendez-Vazquez, H., Khatri, L., Kim, S. Abstract: Ketamine is shown to enhance excitatory synaptic drive in the hippocampus, which is presumed to underlie its rapid antidepressant effects. Moreover, ketamines therapeutic actions are likely mediated by enhancing neuronal Ca2+ signaling. However, ketamine is a noncompetitive NMDA receptor (NMDAR) antagonist that inhibits excitatory synaptic transmission and postsynaptic Ca2+ signaling. Thus, it is a puzzling question how ketamine enhances glutamatergic and Ca2+ activity in neurons to induce rapid antidepressant effects while blocking NMDARs in the hippocampus. Here, we find that ketamine treatment for one hour in cultured mouse hippocampal neurons significantly reduces calcineurin activity to elevate AMPA receptor (AMPAR) subunit GluA1 phosphorylation. This phosphorylation ultimately induces the expression of Ca2+ - permeable, GluA2-lacking, and GluA1-containing AMPARs (CP-AMPARs). Such ketamine-induced expression of CP-AMPARs enhances glutamatergic activity and synaptic plasticity in cultured hippocampal neurons. When a sub-anesthetic dose of ketamine is given to mice, it increases synaptic GluA1 levels, but not GluA2, and GluA1 phosphorylation in the hippocampus within one hour after treatment. These changes are likely mediated by ketamine-induced reduction of calcineurin activity in the hippocampus. Using the open field and tail suspension tests, we demonstrate that a low dose of ketamine rapidly reduces anxiety-like and depression-like behaviors in both male and female mice. However, when in vivo treatment of a CP-AMPAR antagonist abolishes the ketamines effects on animals behavior. We thus discover that ketamine at the low dose promotes the expression of CP-AMPARs via reduction of calcineurin activity in the hippocampus, which in turn enhances synaptic strength to induce rapid antidepressant actions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The right way to race but the wrong way to turn, Supercross goes back to Anaheim. Music by Ketamines!

www.amppod.com AMPpod Podcast - Episode 95 Here is the track listing for the ninety fifth episode of AMPpod. Enjoy! 1. “Mornin’” by Star Slinger 2. “I Don’t Want To Set The World On Fire” by The Ink Spots 3. “The Center” by Tokimonsta 4. “Into The Fields” by Foxes In Fiction 5. “Drama” by Ice T 6. “Going In Circles” by Isaac Hayes 7. “Like You Mean It" by Matthewdavid 8. “Holiday In Cambodia” by Dead Kennedys 9. “Alma” by Gustavo Santaolalla 10. “Stay Awake” by Ketamines 11. “Degrees of Light” by Taylor McFerrin

HE EXISTS IN A PHYSICAL FORM! After a few mishaps we finally managed to get Mr. Jesse Locke in the studio as a guest host. Jesse is the managing editor or Weird Canada and a drummer in the live Ketamines band. He is more interesting than this text box can describe.

KETAMINES vs TOUGH AGE! Two bands face off about drugs, self-loathing, and bein' tough! Hear tunes from Tough Age, Korean Gut, Ketamines, Viet Cong, Paul Jacobs, Pink Wine, King's Quest, F Hood, Soko, and Hoover Party!

Vancouver, British Columbia, Canada's TOUGH AGE are gearing up to release their debut LP on Mint Records in November 2013, but first they decided to tour Ontario with local stalwarts KETAMINES. Patrick and Sam caught them during their Toronto date and recorded an interview with singer/guitarist JARRETT SAMSON. Plus songs by NOBUNNY, BAD SPORTS, OPEN RELATIONSHIP, DIFFERENT SKELETONS, ROUGH KIDS, and MEAN JEANS!

We somehow managed to convince Paul that spending his Wednesday night with us was a good idea. Don't ask me how. You probably know Paul from projects like KETAMINES, WEIRD CANADA, SLAGGINGOFF.TUMBLR.COM and his label MAMMOTH CAVE RECORDINGS, and if you don't, you will after this one. Paul talks what it's like to be "Canada Famous", what it takes to start a label/scene in a small Alberta town only to leave for Toronto. Don't miss this one. Music by Ketamines, Mylean Sheeths, Moby Dicks, Teledrome, Fist City, Gold, Mavo, Viet Cong and more.

The big 1-0! We're playing a bunch of great songs this episode, bunkering down for a string of interview episodes on the horizon. We also talk Toronto's Pleasance Records, record stores, and something else. Music by: Ketamines, The Yolks, White Wires, Bad Sports, Doug Mason, Gay, Taiwan, Hobo Cubes, Shadowy Men On a Shadowy Planet, Thee Make-out Party, Wastoids, Dead Ghosts and more!

Intro: Sonny & The Sunsets - "The Bad Energy From LA Is Killing Me" Harry Manx - "Way Out Back" Sigur Ros - "Brennisteinn" Reagan's Rayguns - "1, 2 Go Punk Song" Divine Hammer - "Weekend" Book of Caverns - "Champion City" Deerhunter - "Monomania" Deerhunter - "Nitebike" Deerhunter - "Punk (La Vie Anterieure" Sheer Agony - "So Many Zoes" Femminielli - "Le Pacte" Chevalier Avant Garde - "Prepare" Jef Barbara - Pas Gentille (Low Sea Remix)" Cinema L'Amour - "Dedication" The Black Rainbows - "She Bites" Scientists of Sound - "Furiosity Killed the Cat" The Ketamines - "Spaceships" Miserere - "To Death Last Year"

Intro: Sonny & The Sunsets - "The Bad Energy From LA Is Killing Me" Harry Manx - "Way Out Back" Sigur Ros - "Brennisteinn" Reagan's Rayguns - "1, 2 Go Punk Song" Divine Hammer - "Weekend" Book of Caverns - "Champion City" Deerhunter - "Monomania" Deerhunter - "Nitebike" Deerhunter - "Punk (La Vie Anterieure" Sheer Agony - "So Many Zoes" Femminielli - "Le Pacte" Chevalier Avant Garde - "Prepare" Jef Barbara - Pas Gentille (Low Sea Remix)" Cinema L'Amour - "Dedication" The Black Rainbows - "She Bites" Scientists of Sound - "Furiosity Killed the Cat" The Ketamines - "Spaceships" Miserere - "To Death Last Year"

We're showcasing some of the best bands from Ottawa, Ontario courtesy of BRUISED TONGUE RECORDS. We also look at some of SAM COFFEY'S biggest fans in the DIY fashion circuit. No, really. Music from Cold Warps, GG King, Teenanger, Ketamines, Shocked Minds, Garry Glitter, Transpotters, The Eeries and many more!

Sam Coffey and The Iron Lungs interview US while we interview THEM! Hear the madness, including talk of Rob Ford, tin foil hats, and shawarma!  Sam interviews Emmanuel and Travis for his radio show PART OF THE NOISE, and we tell a story about Paul Lawton (The Ketamines) almost dying on the radio! PLUS, a preview of next week's drunk interview with NEEDLES//PINS! Hear tracks from Sam Coffey and The Iron Lungs, Hooded Fang, Contingent, Zen Mystery Fogg, Shannon and The Clams, Warm Soda, UN, Vampires, and Manipulation!

UBT - "She Does Too" The Ketamines - "Thank Me Forever" Shawn Mrazek Lives! - "Can't See Me" Poncuation - "Ciao Bye Ciao" Reversing Falls - "Calling You Out" TV Freaks - "Upper Hand" Howl - "Invisible Ghost" Heaven for Real - "Want On" Jay Holy - "You've Become Skeletal" Jay Holy - "Skeletal (Moog Abduction)" Zale To Infinity - "Sky, Sky, Sky" Masters of Love and Sound - "New Dimensions in Conciousness" The Mighty Boosh - "Eels (Jaguar Knight Remix)" Dead Ghosts - "Roky Said" Gold & Youth & Trust - "Lady Bird" Champion - "Dat Train" Zebra Pulse - "Name My Baby" Mark Templeton - "Once Were Down" Mid Pines - "Second Image"

UBT - "She Does Too" The Ketamines - "Thank Me Forever" Shawn Mrazek Lives! - "Can't See Me" Poncuation - "Ciao Bye Ciao" Reversing Falls - "Calling You Out" TV Freaks - "Upper Hand" Howl - "Invisible Ghost" Heaven for Real - "Want On" Jay Holy - "You've Become Skeletal" Jay Holy - "Skeletal (Moog Abduction)" Zale To Infinity - "Sky, Sky, Sky" Masters of Love and Sound - "New Dimensions in Conciousness" The Mighty Boosh - "Eels (Jaguar Knight Remix)" Dead Ghosts - "Roky Said" Gold & Youth & Trust - "Lady Bird" Champion - "Dat Train" Zebra Pulse - "Name My Baby" Mark Templeton - "Once Were Down" Mid Pines - "Second Image"

Paul Lawton of THE KETAMINES talks to us about mutating his band into the ZEBRASSIERS, his SLAGGING OFF blog, and how CITY SLANG should get itself into online trouble! Plus, hear tracks from Zebrassieres, Chains of Love, Milk Music, No Joy, Purling Hiss, WTCHS, Shaker Hymns, JLK & Babysitter, and King Kahn!

BA Johnston, Julian Fane, Ketamines!

Back from hiatus! Tracks from Ketamines and more!

Holy moly, things are crazy in the midwest right now! Tornadoes, hail, sunshine, and a huge pile of badass rock n' roll records to listen to are among the highlights. EPISODE #41 of Random Old Records features an hour of rad jams from what is shaping up to be one of the best music years on record. This is also South By Southwest week, so #41 features a bunch of bands playing the annual music orgy plus so much more!We're talkin' amazing pop tunes from La Sera, Frankie Rose, and Summer Twins, raging punk from LA slackers FIDLAR, the noisy Ramones trip of Terry Malts, and the Denton weird power pop of Mind Spiders. We're talkin' brand NEW tracks from Portland's Mean Jeans and Guantanamo Baywatch, whose new LPs won't be out for another month. We're talkin' brain-frying psychedelic rock n' roll from The Sufis and Ketamines. Most of all, we're talkin' about a track called "Conversation" from one of the most impressive debut LPs I've heard in forever, the 60s sunshine pop/psych hybrid known as OUTER MINDS. Seriously, this album is so good that it's unreal. Think early Arthur Lee and Love mixed with the complex vocal harmonies of The Association, and just run to the record store NOW.Don't forget to SUBSCRIBE to Random Old Records via iTunes, Google Play, or RSS. If you like the show, please rate it and write a review! As always, thanks for listening!Random Old Records Podcast #41Released 03/15/12DOWNLOAD HERE (Right-Click, "Save As")1. Summer Twins - "Got Somebody To Dream About"(Summer Twins, Burger 2012)2. La Sera - "Break My Heart"(Sees The Light, Hardly Art 2012)3. Frankie Rose - "Gospel/Grace"(Interstellar, Slumberland 2012)4. Dreamdate - "What Could I Do"(Melody Walk, Tic Tac Totally 2011)5. Camera Obscura - "Let's Get Out Of This Country"(Let's Get Out Of This Country, Merge 2006)6. Alicja Pop - "I Can't Remember"(I Can't Remember 7", Neat Neat Neat 2011)--Zombie beach party.7. FIDLAR - "No Waves"(No Waves/No Ass 7", Mom & Pop 2012)8. Mean Jeans - "Life On Mars"(On Mars, Dirtnap 2012)9. Terry Malts - "Nauseous"(Killing Time, Slumberland 2012)10. Mind Spiders - "Play You Out"(Meltdown, Dirtnap 2012)11. Glow Kit - "Misunderstood"(Glow Kit, FDH 2012)12. XRay Eyeballs - "Pill Riders"(Splendor Squalor, Kanine 2012)--Hunx is FAMOUS!13. Hunx - "Do You Remember Being A Roller?"(Hairdresser Blues, Hardly Art 2012)14. King Tuff - "Bad Thing"(King Tuff, Sub Pop 2012)15. Teenanger - "Frights"(Frights, Telephone Explosion 2012)16. Spider Fever - "Done Wrong"(Spider Fever, Windian 2012)17. Guantanamo Baywatch - "Chest Crawl"(Chest Crawl, Dirtnap 2012)--Australian new wave explosion!18. Blasted Canyons - "Get High"(2nd Place, Castleface 2012)19. Teledrome - "Double Visions"(Double Visions 7", HoZac 2012)20. The Sufis - "Wake Up"(The Sufis, Burger 2012)21. Ketamines - "Spaced Out"(Spaced Out, Southpaw 2012)22. Outer Minds - "Conversation"(Outer Minds, Southpaw 2012)