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What is the first year of parenthood really like?In this episode, Jeremy is joined by his wife, Heather Scott, as they reflect on the highs, the challenges, the unexpected lessons, and plenty of funny moments from their first year as parents. From sleepless nights and endless diaper changes to the joy of watching your child grow, they share the top 10 things they've learned that no one can truly prepare you for.Whether you're a new parent, expecting your first child, or simply enjoy honest conversations about family and life, this episode is full of laughs, perspective, and reminders to appreciate the little moments that become the big memories.As always, thanks for listening. If you enjoy the show, please leave a review and share this episode with someone who could use it.JSF Nutrition Full Supplement Line HERELove Us? Drop us a 5-star google review HEREFree Week of my Fitness App HERE Join our Built Difference Business Community HERE Thanks to our Sponsors:AG1 CLICK HERE for a 1 year supply of vitamin D3 with free travel packs or want a FREE sample? Trouble with Sleep Try AGZ as well for free: Shoot us a DM and ask!NOBULL Electrolytes Fruit Punch HEREMy Current Fav NOBULL Kicks HEREJaylab Pro Our Protein, Turmeric, Collagen, Krill Oil https://jeremyscottfitness.jaylabpro.com/products.htmlDry Farms Wine - dryfarmwines.com/jeremyscottfitnessEach new member will earn an extra bottle for just a penny with their first order of wine when they use this link.
Discord beware—it's a Jason takeover! Paul's away, which means Jason reluctantly takes the mic and responds to all your Contexts & Opinions (formerly Corrections & Omissions) on our Circus Island episode, including a call from a performer in the movie. Then, writer/producer Justin Halpern (Abbot Elementary, Harley Quinn) chats with Paul and Jason about his hilarious new mystery novel Get Lost, why you'll never see Batman go down on Catwoman on the Harley Quinn TV show, the origins of $#*! My Dad Says, and much more. Plus, Jason announces the first movie we'll be covering for our EXTREME SUMMER series before introducing a mysterious brand-new segment. JASON'S SUMMER PLAYLIST: Rala-Bucho by Antonio Carlos & Jocafi World of Trouble by The Montvales Love of the Song by Jobi Riccio Remenanuèch by Cocanha Tau Special by The Movers I Just Want To Talk To You by Charles Brown & Sleepy Creek T'chuba T'chiba by Dulce Neves Get It Up For Love by Ned Doheny Spring Theme by Fabiano do Nascimento & Vittor Santos e Orquestra Ālibek'agnimi by Tilaye Gebre & Dahlak Band JUSTIN, PAUL, & JASON'S RECS: Predator: Killer of Killers The Dark Wizard Free Solo The Alpinist Lorne Angel Down by Daniel Kraus Carl Hiaasen Elmore Leonard • Go to hdtgm.com for tour dates, merch, FAQs, and more• Leave us a voicemail at speakpipe.com/hdtgm• Submit your Last Looks theme song to us here• Join the HDTGM conversation on Discord: discord.gg/hdtgm• Buy merch at howdidthisgetmade.dashery.com/• Order Paul's book about his childhood: Joyful Recollections of Trauma• Shop our new hat collection at podswag.com• Paul's Discord: discord.gg/paulscheer• Paul's YouTube page: youtube.com/paulscheer• Follow Paul on Letterboxd: letterboxd.com/paulscheer• Subscribe to Enter The Dark Web w/ Paul & Rob Huebel: youtube.com/@enterthedarkweb• Listen to Unspooled with Paul & Amy Nicholson: unspooledpodcast.com• Listen to The Deep Dive with June & Jessica St. Clair: thedeepdiveacademy.com/podcast• Instagram: @hdtgm, @paulscheer, & @junediane• Twitter: @hdtgm, @paulscheer, & msjunediane • Jason is not on social media• Episode transcripts available at how-did-this-get-made.simplecast.com/episodesGet access to all the podcasts you love, music channels and radio shows with the SiriusXM App! Get 3 months free using the link: siriusxm.com/hdtgm Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Lauren Lapkus is a legend in the podcast game, making dozens of legendary appearances as a handful of different colorful characters. But now, she’s sitting down with Danielle to share true (and embarrassing) childhood stories that built who she is today! The Stuart Can’t Save the Universe star admits to immaculately maintained collections of rubber animals, pencils and soaps, while reliving the moment she came face to face with Princess Diana (the actual person, not the Beanie Baby). Plus, Lauren was a good kid - but when she got in trouble…she found TROUBLE. Hear all about it on an all-new Teen Beat!See omnystudio.com/listener for privacy information.
(00:00-20:01) Big Walt coming up at 7:30, JR in studio at 8:40. Blues trade Kyrou so who are the Blusiers gonna hate on now? Good return from Washington. Blues now have four first round picks. Walk & Talks. Gotta question Doug's effort today. The windshield is bigger than the rear view, Chief.(20:09-56:05) Cards announced a presser today. Expectations are a transfer of power in the ownership structure. Is this the end of the Navy Caps On The Road movement? Need to ask at the presser. Maybe we'll send Cal May as a plant. Hockey Hall of Famer and friend of the show, Keith Tkachuk joins the show. Finding out he had made the Hockey Hall of Fame. Incredible run for the Tkachuk family. Matthew and Brady getting to play together in Florida. His role with the Blues and prepping for the draft.(56:15-1:24:13) Trouble with the phone lines yesterday on ATMA. Talking to the Plowhawk yesterday. Audio of Brady Tkachuk talking about his move from Ottawa to Florida. Mark of Mark's Bra & Mulch is really shining. We may have lost Doug. Blues whipping boys over the years. Shrewsbury Seminary Student on hold. Less sports than this show? Wait, Martin's a GILF?!?! A Ghanian witch doctor cursing Harry Kane. It's only weird if it doesn't work.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Big Walt coming up at 7:30, JR in studio at 8:40. Blues trade Kyrou so who are the Blusiers gonna hate on now? Good return from Washington. Blues now have four first round picks. Walk & Talks. Gotta question Doug's effort today. The windshield is bigger than the rear view, Chief.Cards announced a presser today. Expectations are a transfer of power in the ownership structure. Is this the end of the Navy Caps On The Road movement? Need to ask at the presser. Maybe we'll send Cal May as a plant. Hockey Hall of Famer and friend of the show, Keith Tkachuk joins the show. Finding out he had made the Hockey Hall of Fame. Incredible run for the Tkachuk family. Matthew and Brady getting to play together in Florida. His role with the Blues and prepping for the draft.Trouble with the phone lines yesterday on ATMA. Talking to the Plowhawk yesterday. Audio of Brady Tkachuk talking about his move from Ottawa to Florida. Mark of Mark's Bra & Mulch is really shining. We may have lost Doug. Blues whipping boys over the years. Shrewsbury Seminary Student on hold. Less sports than this show? Wait, Martin's a GILF?!?! A Ghanian witch doctor cursing Harry Kane. It's only weird if it doesn't work.Chairman Kurt is now on the floor because JR is with us in studio. Doug made JR pee a little bit. JR was thinking about Harrison's Brother Master as the Kyrou news broke. No reaction from Jordan Kyrou yet. The way Kyrou handled the Berube situation.JR hanging out for another segment. What do the Blues do with these four first-round picks? Taking two-part questions from the audience. Does he see the Blues going big game hunting? The Steen/Armstrong situation. Any news on Binnington? Minor league teams in the Boston suburbs.Biz Markie. Finally getting around to last night's Cardinal loss. Another good start for Kyle Leahy. Things went sideways for Svanson. Audio from MLB Network talking about what direction the Cardinals and Chaim Bloom might go at the deadline and the need for swing and miss stuff on the pitching staff. Aroldis Chapman. Brewers just keep on winning. White Sox in first in the AL Central.Doug is this Vapors? Audio of a Miami reporter interviewing some fans from Scotland and maybe she wishes she wouldn't have. Wyndham Clark on Pardon My Take talking about an old tweet about Baker Mayfield and an ex-girlfriend. The hatred for Wyndham Clark. Gallon of Tim's love.Design Aire Heating & Cooling EMOTDStifel Market Moves. The Athletic's Player Poll with MLB players shows that 80% of players believe there will be a work stoppage. Cafe Americano. Matcha tastes like potting soil.People are making topic requests. Johnny Layup wants thoughts on the Kyrou move. Favorite trades in STL history. McGwire, Holliday, Edmonds. Mental and testicular fortitude.Doug Armstrong press conference coming up at the top of the hour. 1 PM press conference for the Redbirds. Mt. Rushmore of St. Louis pro sports owners.And the winner of the Design Aire Heating & Cooling EMOTD is…See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Is the Royals Stadium Deal in Trouble in Kansas City? | Mundo Clip 6-24-26See omnystudio.com/listener for privacy information.
On today's Rizz Show episode the gang discusses Food terrorism, Headphone Heists, Youth Coaches crushing dreams, Tornado of Trouble, and a man at the Airport redefines what Brown can do for you! All that plus, the return of Do it Bitch and Rocked dot net 's Luke Spencer stops by to break down bands that should retire vs Bands that changed their style and it worked!Then things get weird, because naturally they do.The crew dives into the modern dating scene and discovers that your future soulmate might reject you over the state of your vehicle. Apparently, a pile of fast-food bags and a suspiciously sticky cup holder are enough to send your romantic prospects directly into reverse. The gang debates whether a messy car means a messy life, why teenagers suddenly become cleaning experts when they're dating someone, and whether your car is secretly a giant rolling personality test.Along the way, there are conversations about World Cup dating strategies, international soccer fans creating accidental baby booms, and why bagpipes might actually be the soundtrack of the underworld. Somehow, all of this makes perfect sense in a comedy podcast.As always, the crew takes ordinary stories and turns them into complete nonsense. One minute it's concert ticket technology and oversized bags at venues. The next minute it's relationship advice based entirely on how many french fries are living under your passenger seat. It's daily chaos, sarcastic humor, and the kind of conversations that make you laugh because you're pretty sure you've been guilty of at least one of these things.Whether you're a neat freak with a spotless interior or someone whose car doubles as long-term storage, this episode has something for you. It's another round of weird news, relatable fails, and completely unnecessary debates from your favorite St. Louis morning crew. This comedy podcast delivers concert stories, dating observations, and enough self-roasting to keep everybody humble.Grab your coffee, clean out your cup holders, and join Rizz and the gang for another ridiculous ride because this comedy podcast proves once again that everyday life is way funnier than anybody planned.Follow The Rizzuto Show → linktr.ee/rizzshow for more from your favorite daily comedy show.Connect with The Rizzuto Show online → 1057thepoint.com/RizzShowHear The Rizz Show daily on the radio at 105.7 The Point | Hubbard Radio in St. Louis, MO.Man records tornado destroying his home around himSt. Louis firefighter accused of defecating in box at Lambert AirportArby's manager accused of spitting in customer's food, giving her herpesChild sprays aerosol near smoking adult and causes explosion, NC officials saySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Truth.Love.Parent. with AMBrewster | Christian | Parenting | Family
You can't shelter your children from worldly thinking, but you must teach them to fight it. Join AMBrewster to learn 2 necessary steps to fighting the World in your home.Truth.Love.Parent. is a podcast of Truth.Love.Family., an Evermind Ministry.Action Steps Purchase “Quit: how to stop family strife for good.” https://amzn.to/40haxLz Support our 501(c)(3) by becoming a TLP Friend! https://www.truthloveparent.com/donate.html Download the Evermind App. https://evermind.passion.io/checkout/102683 Use the promo code EVERMIND at MyPillow.com. https://www.mypillow.com/evermind Discover the following episodes by clicking the titles or navigating to the episode in your app: Fighting Satan, the World, and the Flesh https://www.truthloveparent.com/spiritual-warfare-in-your-home.html Evangelism Parenting https://www.truthloveparent.com/evangelism-parenting-series.html Discipleship Parenting https://www.truthloveparent.com/discipleship-parenting-series.html The Biggest Parenting Challenges You Will Ever Face https://www.truthloveparent.com/biggest-parenting-challenges-you-will-ever-face.html Turn Bad Influences into Non-Influences https://www.truthloveparent.com/taking-back-the-family-blog/tlp-196-turn-bad-influences-into-non-influences Parents, Kids, and Techtation https://www.truthloveparent.com/taking-back-the-family-blog/tlp-25-parents-kids-and-techtation The Merest Christianity https://www.truthloveparent.com/the-merest-christianity-series.html The Most Destructive Thing about Your Entertainment is Not What You'd Think https://www.truthloveparent.com/taking-back-the-family-blog/tlp-170-the-most-destructive-thing-about-your-entertainment-is-not-what-youd-think Click here for Today's episode notes, resources, and transcript: https://www.truthloveparent.com/taking-back-the-family-blog/tlp-637-the-only-way-to-fight-the-worlds-culture-in-your-homeLike us on Facebook: https://www.facebook.com/TruthLoveParent/Follow us on Instagram: https://www.instagram.com/truth.love.parent/Follow us on Twitter: https://twitter.com/TruthLoveParentPin us on Pinterest: https://www.pinterest.com/TruthLoveParent/
In This House Will Feed by Maria Tureaud, Maggie, a young woman trying to survive the Great Hunger in Ireland, is rescued from a workhouse by the enigmatic Lady Catherine, who brings Maggie back to her estate home. She promises Maggie a roof over her head, food to eat, and, eventually, a shockingly ample plot of land to call her own–with one catch. Maggie must pretend to be Lady Catherine's daughter Wilhelmina. It seems too good to be true–and Maggie may be in more danger than she realizes. Recommended in this episode: Widow's Bay on Apple TV and The Other Bennet Sister on BritBox NEWS: We have a Bookshop.org shop now! Find all of our favorite books at our shop–and help out small businesses. HUGE CONGRATULATIONS TO DANIEL KRAUS ON HIS PULITZER WIN! UP NEXT: Dollface by Lindy Ryan Buy our books here, including Monster, She Wrote and our newest Toil and Trouble.
The Buck Reising Show Hr 2- Trouble for College Hoops, NFL Headlines & Why Did Dusty Leave?See omnystudio.com/listener for privacy information.
Stupid News 8am 6-22-2026 …Watch Out for Falling Signage …Why Panhandle for Money when Your AI Robot Can Do it for You? …Trouble on the Pickleball Court
This is our weekly, ad-free compilation of science news.00:00 - Did Physics Just Lose a Brilliant Idea?5:30 - Maths is Cooked: AI's Latest Breakthrough -- And What's Next11:24 - Nuclear Fusion is in Trouble
The Buck Reising Show Hr 2- Trouble for College Hoops, NFL Headlines & Why Did Dusty Leave?See omnystudio.com/listener for privacy information.
River of Life is an inter-denominational, interracial, Spirit-filled church located in the heart of Wakulla County, Florida. We share the sermons from our services in the hopes they'll reach others determined to worship God in spirit and truth.
River of Life is an inter-denominational, interracial, Spirit-filled church located in the heart of Wakulla County, Florida. We share the sermons from our services in the hopes they'll reach others determined to worship God in spirit and truth.
If I had to start over at 42 and rebuild my fitness, nutrition, business, and relationships from scratch, this is exactly what I would do.In this episode, I share the 5 biggest lessons and priorities I would focus on in each area of life to get healthier, stronger, more successful, and more fulfilled. No hacks. No shortcuts. Just the fundamentals that actually work.We cover: Fitness after 40, Simple nutrition habits, Business growth principles, Stronger relationships, The power of consistency over perfection. JSF Nutrition Full Supplement Line HERECODE "DAD15" for 15% Father's Day Sale June 21st/22nd ONLYLove Us? Drop us a 5-star google review HEREFree Week of my Fitness App HERE Join our Built Difference Business Community HERE Thanks to our Sponsors:AG1 CLICK HERE for a 1 year supply of vitamin D3 with free travel packs or want a FREE sample? Trouble with Sleep Try AGZ as well for free: Shoot us a DM and ask!NOBULL Electrolytes Fruit Punch HEREMy Current Fav NOBULL Kicks HEREJaylab Pro Our Protein, Turmeric, Collagen, Krill Oil https://jeremyscottfitness.jaylabpro.com/products.htmlDry Farms Wine - dryfarmwines.com/jeremyscottfitnessEach new member will earn an extra bottle for just a penny with their first order of wine when they use this link.
Love can be pretty unrelenting. It's turgidity and its persistence can be intimidating to people who see it collapsing under its own weight and can't understand how it is still standing strong. People in love can separate without disengagement but equally they can continue loving with separation. Anything anchored in emotion has moorings which may seem fragile but are often unrelenting. Nobody knows inner stories, of holding on to ties, of despair and of not giving up. Logic falls by the wayside. Trouble starts when reconciliations are compromised without addressing the cause, the core of what eats away at the soul. What draws people to each other is either what resonates or the things they miss in themselves. It's only later that the true differences of nature and thought get revealed. The sunken body of the iceberg can then be seen. And it is not always pleasant, and it often rests against the very grain of what the other stands for. The true challenge of love starts there. Because ignoring what haunts is to let our inner turmoil and resistance and unwilling consent keep eating the foundation like termite, even as the newly-painted facade of coupledom glistens in public glow. If you liked this poem, consider listening to these other poems on ways of the resilience of love - Marriage Made Me a Philosopher The Long Now of Us It Takes Time for Love to Find Comfort Subscribe to my newsletter 'The Uncuts' Follow me on Instagram at @sunilgivesup. Get in touch with me on uncutpoetrynow@gmail.com The details of the music used in this episode are as follows - Imagefilm15 by Sascha Ende Link: https://filmmusic.io/en/song/Imagefilm15 Licence: https://filmmusic.io/standard-license
When the crooks and the coppers join forces, London's criminal underworld is in very confused hands. For Episode 199, Reel Britannia slips into the sharply dressed, cheerfully crooked world of The Wrong Arm of the Law, a 1963 British crime comedy in which the nation's criminals discover that even dishonesty was better organised in the old days. Peter Sellers stars as Pearly Gates, a suave London gang boss who divides his time between running a fashion house and supervising a criminal organisation with the efficiency of a suburban business. His employees may be thieves, but they enjoy paid holidays, luncheon vouchers and a surprisingly enlightened approach to staff welfare. Crime, it seems, was never so civilised. Trouble arrives when a gang of Australian crooks begins impersonating police officers and helping themselves to the proceeds of other people's robberies. This is regarded as extremely poor form. With both Scotland Yard and the London underworld irritated, Pearly finds himself entering into an unusual alliance with Inspector "Nosey" Parker, played with glorious bluster by Lionel Jeffries. Directed by Cliff Owen and written by a team that includes Ray Galton and Alan Simpson, the film surrounds Sellers with a marvellous collection of familiar British faces. Bernard Cribbins brings nervous energy to Pearly's reluctant associate O'Toole, while John Le Mesurier appears with the beautifully weary air of a man who has already filled in far too many forms. The Wrong Arm of the Law is a breezy caper filled with bungling crooks, pompous policemen, double-crosses and a reassuring amount of London location work. It belongs to that wonderful strain of British comedy in which authority is treated with suspicion, crime is conducted by committee, and nobody appears capable of organising anything without first stopping for tea. Join us for Episode 199 of Reel Britannia, as we revisit a British battle between law and disorder — with just a hint of professionalism. All episodes available on your favourite podcast catcher Head over to Patreon for special bonus episodes Follow us on X @rbritanniapod
El 18 de junio de 1966 nacía John Michael Dexter Romweber II. Dex Romweber abandonó este mundo en febrero de 2024.En el día en que cumpliría 60 años celebramos el legado de uno de los artistas más genuinos y cautivadores en el underground de las últimas cuatro décadas. Dexter lideró el influyente grupo Flat Duo jets, un dúo de rock’n’roll primitivo y salvaje que sirvió de inspiración directa a The White Stripes o The Black Keys.Ya en el siglo XXI continuaría su trayectoria lanzando los discos a su nombre, abriendo su abanico musical y emocional, y esa segunda etapa es la que vamos a sobrevolar.(Foto del podcast por Kenneth Bachor)Playlist;(sintonía) DEX ROMWEBER “Out of the way” (Carrboro, 2016)DEX ROMWEBER “Good thing goin’” (Good thing goin’, 2023)DEX ROMWEBER “Is that you in the blue?” (Is that you in the blue?, 2011)DEX ROMWEBER “The death of me” (Is that you in the blue?, 2011)DEX ROMWEBER and JACK WHITE “Last kind word Blues” (2009)DEX ROMWEBER DUO feat CAT POWERS “Love letters” (Ruins of Berlin, 2011)DEX ROMWEBER DUO feat CAT POWERS “Still around” (Ruins of Berlin, 2011)DEX ROMWEBER DUO “So sad about us” (Images 13, 2014)DEX ROMWEBER DUO “Baby I know what it's like to be alone” (Images 13, 2014)DEX ROMWEBER “Trouble of the world” (Carrboro, 2016)DEX ROMWEBER “Saturday morning” (Good thing goin’, 2023)DEX ROMWEBER “Blues that defy my soul” (Blues that defy my soul, 2004)DEX ROMWEBER “Smile” (Carrboro, 2016)DEX ROMWEBER “Prelude in A minor” (Piano, 2006)DEX ROMWEBER “The 309” (Blues that defy my soul, 2004)DEX ROMWEBER DUO “Weird (Aurora borealis)” (Images 13, 2014)DEX ROMWEBER DUO “We’ll be together again” (Images 13, 2014)Escuchar audio
Le problème n'est pas toujours ce qu'il y a eu en trop. Parfois, c'est ce qui n'a pas été là. Dans cet épisode, Gwénaëlle Persiaux, psychologue clinicienne et thérapeute, vient déplacer le regard sur l'addiction, le trauma d'attachement et ses manques invisibles qui peuvent plus tard déborder dans les conduites addictives. Dissociation, faux self, corps qui garde la mémoire, un épisode puissant sur ce qu'on cherche parfois à calmer juste pour survivre.
On this episode of THE HOT MIC, John Rocha and Jeff Sneider talk new Spider-Man BND trailer teasing more Jean Grey, Ridley Scott is messing with Alien Romulus sequel, Charles Melton for Beast and X-Men reboot's “big swing” from Marvel, Wagner Moura for Oceans villain, Daniel Kaluya and Teyana Taykor for Shaka King's next movie, Toy Story 5 review, Brad Bird's Ray Gunn fiasco pits Netflix vs Paramount, Austin Powers 4 is happening and Shrek 5 trailer animation critiques, Netflix is or is not buying Lionsgate story, Bradley Cooper and Sean Penn teaming up for Jan 6th movie, Anya Taylor Joy in The Hunt for Gollum, thoughts on Rogen and Franco situation, Fox to buy Roku for 22B and more!HOT MIC MERCH LINK: https://www.bestnametape.com/The-Hot-Mic-Shop-s/4592.htm#spiderman #marvel #alien #lordoftherings #TheHotMic #JeffSneider #JohnRocha ____________________________________________________________________________________Chapters:0:00 Intro, Rundown and Catch Up3:02 Jim Carrey and Ron Howard Reteaming for a Grinch Sequel7:02 Mike Myers Confirms an Austin Powers 4 Film is Happening10:28 James Wan to EP Robocop Series and Direct Episodes for Amazon MGM12:55 Wagner Moura in Talks to Play the Villain in Oceans Prequel16:25 Anya Taylor Joy Cast in The Hunt for Gollum in New Role19:14 The Wrap's Drew Taylor Joins to Talk Ray Gunn/Netflix/WB Issues32:58 Charles Melton Joins the Daniels New Film35:40 Melton Mentioned for Beast in X-Men, Marvel Takes 'Big Swin' with X-Men41:28 Spider-Man Brand New Day Trailer Talk - Jean Grey Inevitability?44:26 WB Moves Up Social Reactions for Supergirl - Confidence or Trouble?50:20 Ridley Scott is Gumming Up the Works for an Alien Romulus Sequel54:18 Sneider Pushes Back on Critics Over His The Batman Part 2 Scoop57:55 New Shaka King Movie Unites Daniel Kaluya and Teyana Taylor59:49 Ryan Coogler Moves His First Look Deal from Disney to Netflix1:01:18 FOX Buys Roku for 22B dollars, Accruing More IP?1:05:39 Sean Penn to Direct Bradley Cooper in January 6th Movie1:07:52 Tom Cruise Hunting for Horror Movies, Star Trek Looking for a Training Day Movie1:20:42 Streamlabs and Superchat QuestionsFollow John Rocha: @therochasays Follow Jeff Sneider: @TheInSneider Become a supporter of this podcast: https://www.spreaker.com/podcast/the-hot-mic-with-jeff-sneider-and-john-rocha--5632767/support.
Truth.Love.Parent. with AMBrewster | Christian | Parenting | Family
Parenting can be scary. But God wants you to be a courageous parent, so join AMBrewster to learn what it takes to have more courage.Truth.Love.Parent. is a podcast of Truth.Love.Family., an Evermind Ministry.Action Steps Purchase “Quit: how to stop family strife for good.” https://amzn.to/40haxLz Support our 501(c)(3) by becoming a TLP Friend! https://www.truthloveparent.com/donate.html Download the Evermind App. https://evermind.passion.io/checkout/102683 Use the promo code EVERMIND at MyPillow.com. https://www.mypillow.com/evermind Discover the following episodes by clicking the titles or navigating to the episode in your app: The Merest Christianity https://www.truthloveparent.com/the-merest-christianity-series.html Teach Your Children to Obey https://www.truthloveparent.com/teach-your-children-to-obey-series.html Peaceful Parenting https://www.truthloveparent.com/peaceful-parenting-series.html Parenting Fearful Children https://www.truthloveparent.com/parenting-fearful-children.html Parenting in Christ https://www.truthloveparent.com/parenting-in-christ-series.html Biblical Parents https://www.truthloveparent.com/biblical-parent-series.html Biblical Parenting Essentials https://www.truthloveparent.com/biblical-parenting-essentials.html Click here for Today's episode notes, resources, and transcript: https://www.truthloveparent.com/taking-back-the-family-blog/tlp-636-how-to-be-a-courageous-parent Download the Evermind App! https://evermind.passion.io/checkout/102683Like us on Facebook: https://www.facebook.com/TruthLoveParent/Follow us on Instagram: https://www.instagram.com/truth.love.parent/Follow us on Twitter: https://twitter.com/TruthLoveParentPin us on Pinterest: https://www.pinterest.com/TruthLoveParent/Subscribe to us on YouTube: https://www.youtube.com/channel/UCTHV-6sMt4p2KVSeLD-DbcwClick here for more of our social media accounts: https://www.truthloveparent.com/presskit.htmlNeed some help? Write to us at Counselor@TruthLoveParent.com.
In this latest update from Colombia Calling and Colombia Reports, we look at the most recent developments in the lead into the second round of the presidential elections on 21 June. Ivan Cepeda revives the parapolitica scandal and accuses rival of being a member of the right wing AUC paramilitaries. Has the Pacto Histórico shifted from its slumbering state? We look at the different accusations levied at Abelardo de la Espriella, including fraud, bribery, corruption and connections to drug traffickers. Also, what does it mean that Aberlardo de la Espriella is a US citizen? Trouble ahead? And tune in to the Colombia Briefing reported by Emily Hart.
Digital Drama 6-16-2026 …Trouble in Trivia Paradise …Neighborhood Fireworks is the Sound of Freedom
What's on your mind?What in the 250 capsule?Should she? Should she return the gift?Trouble in the work computer search3 in the QCCan't Beat LauRen Summer Camp Maney mispronounces countries See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Sabrina Ionescu is BACK — and the New York Liberty are headed to the Commissioner's Cup Final. New York clinched with an 86-64 win over Washington on Sunday, extending their winning streak to SEVEN games and moving to 10-4 atop the Eastern Conference. Erica and Brian break it all down LIVE tonight at 7:30 PM ET.
The Love, Happiness and Success Podcast With Dr. Lisa Marie Bobby
By the time an adult child finally says “I'm done,” they have usually been deciding it for about three years. The parent almost never sees it coming. The child was never once surprised. On the other side, the pain and anger that comes when someone you love with all your heart and soul refuses to talk to you? It's as crushing as it is confusing. This episode is for anyone who has ever sat in the car outside a parent's house, bracing themselves before they walk in. And it is just as much for the parent staring at a phone that has gone quiet, replaying what they could have done differently. If your relationship with your parent, or with your grown kid, has started to feel like a careful performance instead of a real connection, you are not imagining it, and you are not stuck with it. If it feels like bridges have been burned, there is a way back. In this episode you'll learn about the small, respectful shifts that re-open lines of communication, rebuild trust, and develop an enduring v.2 for your relationship. Episode Breakdown: 00:00 Blindsided: Why Adult Children Pull Away 11:11 No One's to Blame, Everyone's Responsible 16:47 Why Adult Children Stop Being Honest With You 21:04 "Am I in Trouble?": When the Past Hijacks the Present 22:47 Raising From the Inside Out: The Foundation You Set Now 33:50 The Letter, the Agenda, and the Boundary 42:30 Grieving the Expectations You Handed Them 48:42 The PARENT Method, and the One Thing Bigger Than the Issues Resources: Full episode show notes and everything mentioned Book a free consultation with a therapist who specializes in this If this conversation stirred something up, that is worth paying attention to. You do not need to be in crisis to talk to someone. Come find us at GrowingSelf.com and schedule a free consultation. We will help you figure out what is actually going on between you and your parent, or you and your grown child, and what to try next. No pressure, no commitment, just a real conversation. XO, Dr. Lisa Marie Bobby Growing Self Special thanks to this month's sponsors of the podcast: Upwork — When you need specialized talent fast, Upwork gives you access to vetted professionals across 125+ categories, from marketing to web development to operations support. No long recruiting cycles. No guesswork. Just the right person, when you need them. Check it out at upwork.com — posting a job is free. Shopify — The all-in-one platform for building and growing your online business. Visit shopify.com/lhs to explore their tools and access exclusive listener discounts. OSEA — Amazing, clean, science-backed skincare made with the power of the sea. Use code LHS at oseamalibu.com for 10% off your first order. LNutra Prolon — A science-backed, plant-based nutrition program that supports fat loss, metabolism, cellular rejuvenation, and overall longevity. Head to ProlonLife.com/LHS for 15% off your first order + a bonus gift.
Kat Crowder grew up in Alabama with an alcoholic father and started getting into trouble as a teenager — eventually getting sent to a troubled teen program that was supposed to help but couldn't prepare her for what came next. When she got out her father took his own life. That loss derailed everything. In this episode of Locked In with Ian Bick, Kat tells the complete story — from her teenage years spiraling into identity theft check fraud and in and out of Tennessee jails to eventually catching a case in Ohio and spending nearly a year inside an Ohio state prison. But what makes her story completely unique right now is who she was locked up with. Kat was in Ohio prison with Mackenzie Shirilla — the subject of the viral Netflix crash documentary — and she went viral for sharing what Mackenzie was really like inside. The Netflix documentary got it wrong. Kat was there. This is the complete unfiltered truth. _____________________________________________ #MackenzieShirilla #OhioPrison #truecrimecommunity _____________________________________________ Thank You To CASH APP For Sponsoring This Episode: Download Cash App Today: https://click.cash.app/ui6m/6pao71et #CashAppPod Cash App is a financial services platform, not a bank. Banking services provided by Cash App's bank partner(s). Prepaid debit cards issued by Sutton Bank, Member FDIC. Cash App Visa® Debit Flex Cards issued by Sutton Bank, Member FDIC, and The Bancorp Bank, N.A., pursuant to a license from Visa U.S.A. Inc. See terms and conditions for the Sutton prepaid card, Sutton debit flex card, and Bancorp debit flex card. Discounts and promotions provided by Cash App, a Block, Inc. brand. Visit cash.app/legal/podcast for full disclosures. _____________________________________________ Connect with Kat Crowder: TikTok: https://www.tiktok.com/@boujeebehindbars Instagram: https://www.instagram.com/boujeebehindbars/ YouTube: https://www.youtube.com/@boujeebehindbars _____________________________________________ Hosted, Executive Produced & Edited By Ian Bick: https://www.instagram.com/ian_bick/?hl=en https://ianbick.com/ _____________________________________________ Timestamps: 00:00 She Was Locked Up With Mackenzie Shirilla — Kat's Complete Story 02:30 Her Struggles at Home and the Teenage Turmoil That Started Everything 05:30 The Rebellion the Troubled Teen Program and the Family Tragedy That Changed Everything 09:30 What the Troubled Teen Program Was Really Like From the Inside 12:00 Coming Home to Find Her Dad Gone — Grief and the Coping Mechanisms That Followed 16:20 College Substance Abuse and the Escalating Behavior That Nobody Could Stop 19:30 The Legal Troubles That Started the Criminal Justice Cycle She Couldn't Break 24:30 Probation Drug Court and the Setbacks That Kept Setting Her Back 28:20 The Criminal Lifestyle and the Consequences That Finally Caught Up With Her 32:00 The High Speed Chase and What Jail Really Felt Like for the First Time 36:00 Getting Pregnant in Jail and the Turning Point That Changed How She Saw Everything 41:00 Sentencing Day and What Heading to Ohio State Prison Actually Felt Like 45:00 Her First Impressions of Ohio State Prison and What Nobody Prepares You For 47:40 What Women's Prison Is Really Like — The Truth Nobody Talks About Publicly 50:30 The Prison Programs That Kept Her Out of Trouble and What She Learned From Them 53:00 Being Locked Up With Mackenzie Shirilla — What She Was Really Like Inside 57:00 Prison Hierarchy Gossip and How Perceptions of Mackenzie Shifted Inside 01:00:00 Contraband Relationships and the Everyday Challenges of Ohio State Prison 01:05:00 Prison Hustles and Pen Pals — The Underground World Nobody On the Outside Sees 01:09:00 Ohio Prison Food Commissary Life and the Halfway House Transition 01:15:00 Coming Home — Reuniting With Family and What Moving Forward Really Looked Like 01:19:00 Why She Finally Decided to Share Her Story Online and What Happened Next 01:22:00 The Lessons She Learned and the Reflections That Changed How She Sees Everything 01:25:00 Rebuilding Family Bonds and Her Advice to Anyone Who Needs to Hear It 01:26:30 Her Final Words and the Message She Wants to Leave With Everyone Watching _____________________________________________ To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/LockedInWithIanBicka Learn more about your ad choices. Visit podcastchoices.com/adchoices
The Enlightened Family Business Podcast Ep. 162: You May Be Making Decisions in the Dark — Jacques Santucci on Financially Preparing Your Business for the Future In this episode of the Enlightened Family Business Podcast, host Chris Yonker sits down with Jacques Santucci, President of Opus Consulting, for a grounded, practical conversation about one of the most underutilized levers in family business: financial leadership. Jacques brings a rare combination of international business experience — from Ernst & Young in France to CFO roles in the US — and 17 years of consulting to privately held and family-owned businesses across New England and beyond. Together, Chris and Jacques break down the critical differences between a bookkeeper, controller, and CFO; why so many family businesses are making major decisions with months-old data; what the early warning signs of financial trouble actually look like before an owner recognizes them; and why the fractional CFO model has become one of the most accessible and high-impact resources available to growing family firms. They also explore what a meaningful financial education pathway looks like for the rising generation — not to make them accountants, but to ensure they can read a P&L, understand a balance sheet, talk to a banker, and make decisions grounded in fact rather than gut feeling. Episode Chapters · 4:10 Meet Jacques Santucci · 7:12 From France to Maine: A CFO's Unlikely Journey · 11:04 Bookkeeper, Controller, CFO — What's the Difference and Why It Matters · 17:12 The CFO's Real Job: Looking at the Future, Not the Past · 19:25 When Is It Time to Bring In a CFO? · 21:33 Financial Reporting: What to Measure, How Often, and Why · 25:31 Early Warning Signs Your Business Is Heading for Trouble · 29:16 Customer Mix, Profit Margins, and Strategic Decision-Making · 30:16 A Real-World Case Study: Seasonal Business, Six-Week-Old Data, and What Changed · 31:47 Clean Data: Why Accuracy Is the Foundation of Every Good Decision · 35:20 Developing the Rising Generation's Financial Acumen · 40:08 What Every Next-Gen Leader Needs to Understand About the Numbers · 42:16 The Fractional CFO Model: Full Expertise at a Fraction of the Cost · 46:05 Resources and Farewell Websites · opuscg.com · chrisyonker.com About Jacques Santucci Jacques Santucci is the President and Founder of Opus Consulting, a nationally recognized full-service business advisory firm supporting companies from start-up to turnaround, and offering management and fractional C-suite services to unlock performance. Jacques is particularly skilled in helping businesses navigate complex inflection points and difficult industries, with over 20 years of experience in turnarounds and restructurings. He frequently serves as a restructuring officer, court-appointed receiver, or turnaround advisor — bringing disciplined execution and a practical, hands-on approach to each engagement. In his capacity as a fractional CFO, Jacques utilizes his strategic and financial expertise to help companies improve fiscal controls, cash flow, and align financial operations with long-term goals. From his frontline perspective in restructuring and turnarounds, he is keenly aware of the financial decisions and factors that lead companies into distress — and works with business leaders to avoid those pitfalls earlier in the business lifecycle. Jacques built his career as a strategic finance leader, holding senior roles at Ernst & Young and Universal Pictures in Paris, France, before bringing his expertise to privately held and family-owned businesses across the United States.
Local indie folk unit Trouble's Braids released their newest EP Tarantula on June 5th, and to talk about the release and their upcoming group performances, co-founder Emily Pennington joins this week's episode of Music of the Mountains!Our theme song is courtesy of singer-songwriter Brittney Wagner. Stream her record Better off Dead here. Support the showThank you for listening to The Mountain-Ear Podcast, featuring news and culture from peak to peak! Additional pages are linked below.If you want to be involved in the podcast or paper, contact:Barbara Hardt, our editor-in-chief, at info@themountainear.comTyler Hickman, multimedia producer, at tyler@themountainear.comJamie Lammers, podcast host, at media@themountainear.comGeneral inquiries: frontdesk@themountainear.comHead to our website for all of the latest news. Subscribe to The Mountain-Ear in print and online.Submit local events to promote them in the paper and on our website.Find us on Facebook @mtnear and Instagram @mtn.earListen and watch on YouTube today.Share this podcast by scrolling to the bottom of our website home page or by heading to our main hub on Buzzsprout.Thank you for listening!
"""Out of Hand"" ENTOMBED Wolverine Blues ""title BAD RELIGION Recipe For Hate" "Sadhu Satana"" IMPALED NAZARENE Ugra-Karma ""No Love Lost"" CARCASS Heartwork" ""A Twist in the Tale"" DEEP PURPLE The Battle Rages On ""Ride""CATHEDRAL The Etherial Mirror" ""Unholy Black Metal"" DARKTHRONE Under A Funeral Moon ""On Your Feet Or On Your Knees"" MOTORHEAD Bastards" "Demacrator"" COMECON Converging Conspiracies ""Trouble"" DANZIG Thrall-Demonsweatlive" ""A Sign For the Norse Hordes To Ride"" IMMORTAL Pure Holocaust ""Biotech Is Godzilla"" SEPULTURA Chaos AD" ""Only"" ANTHRAX Sound of White Noise ""Between Sun and Moon"" RUSH Counterparts" "title SACRED REICH Independent ""title"" UNCLE SLAM Will Work For Food"
What nobody tells you about getting older is that life doesn't necessarily get easier, but you become stronger, wiser, more patient, and more capable of carrying the weight that comes with it.In this episode, I share the biggest lessons I've learned as a 42-year-old dad raising a young son while also watching my parents get older. We talk about the realities of aging, balancing family, health, career, and responsibility, and why many of the things we once chased matter far less than we thought they would.If you're navigating midlife and trying to make the most of your health, relationships, and time, this episode is for you.JSF Nutrition Full Supplement Line HERELove Us? Drop us a 5-star google review HEREFree Week of my Fitness App HERE Join our Built Difference Business Community HERE Thanks to our Sponsors:AG1 CLICK HERE for a 1 year supply of vitamin D3 with free travel packs or want a FREE sample? Trouble with Sleep Try AGZ as well for free: Shoot us a DM and ask!NOBULL Electrolytes Fruit Punch HEREMy Current Fav NOBULL Kicks HEREJaylab Pro Our Protein, Turmeric, Collagen, Krill Oil https://jeremyscottfitness.jaylabpro.com/products.htmlDry Farms Wine - dryfarmwines.com/jeremyscottfitnessEach new member will earn an extra bottle for just a penny with their first order of wine when they use this link.
Psalm 119:129-144 English Standard Version Pe 129 Your testimonies are wonderful; therefore my soul keeps them. 130 The unfolding of your words gives light; it imparts understanding to the simple. 131 I open my mouth and pant, because I long for your commandments. 132 Turn to me and be gracious to me, as is your way with those who love your name. 133 Keep steady my steps according to your promise, and let no iniquity get dominion over me. 134 Redeem me from man's oppression, that I may keep your precepts. 135 Make your face shine upon your servant, and teach me your statutes. 136 My eyes shed streams of tears, because people do not keep your law. Tsadhe 137 Righteous are you, O Lord, and right are your rules. 138 You have appointed your testimonies in righteousness and in all faithfulness. 139 My zeal consumes me, because my foes forget your words. 140 Your promise is well tried, and your servant loves it. 141 I am small and despised, yet I do not forget your precepts. 142 Your righteousness is righteous forever, and your law is true. 143 Trouble and anguish have found me out, but your commandments are my delight. 144 Your testimonies are righteous forever; give me understanding that I may live. English Standard Version (ESV) The ESV® Bible (The Holy Bible, English Standard Version®), © 2001 by Crossway, a publishing ministry of Good News Publishers.ESV Text Edition: 2025.
This week, comedy club manager Harvey Lampkin jumps down into the NNFA Turtle Lair to discuss everything from AI-generated music and TikTok culture to DoorDash disasters, old-school discipline, and why it feels like nobody is actually working anymore. We get into the most ridiculous apologies of the week, why chest hair is making a comeback, AI songs and the future of creativity, why people are livestreaming their entire lives, the decline of traditional jobs and rise of internet hustle culture, Hip-hop, rap lyrics, and whether some artists need to retire certain topics, viral videos that have the whole internet talking, plus, Cardi B, subway dancers, and one of the wildest dog-camera videos you'll ever see!Watch “Gone in 60 Seconds"! → https://youtube.com/shorts/zaI8aiCV36E?si=KkQp5ksgcFI-AHUo DON'T FORGET TO LIKE, SHARE & SUBSCRIBE https://www.youtube.com/channel/UCLAUp-4rTF4q4XLujbJ51YQ MERCH https://nnfa.creator-spring.com/ BONUS CONTENT https://www.patreon.com/c/ImDaveTemple?utm_medium=clipboard_copy&utm_source=copyLink -----------------Follow host Derek GainesIG https://www.instagram.com/thegreatboy/ YouTube https://www.youtube.com/channel/UCEQDlfXd3hPcpTkU8xHYBTg Follow host Dave TempleIG https://www.instagram.com/imdavetemple/ YouTube https://www.youtube.com/@DAT46Follow guest Harvey LampkinIG https://www.instagram.com/harveylee22/ Follow No Need for ApologiesIG https://www.instagram.com/nnfapodcast/ TT https://www.tiktok.com/@noneedforapologies FB https://www.facebook.com/noneedforapologies/Produced by Teona SashaIG https://www.instagram.com/teonasasha/TT https://www.tiktok.com/@teonasasha -----------------To advertise your product on our podcasts please email jimmy@gasdigitalmarketing.com with a brief description about your product and any shows you may be interested in advertising on.SEND US MAIL:GaS Digital StudiosAttn: NNFA151 1st Ave # 311New York, NY 10003"No Need for Apologies" - NEW Episodes every Saturday at 3PM/ET on YouTube-----------------⏱️CHAPTERS00:00 Intro00:45 Welcome to the Show02:30 Dave's Rental Car Apology08:42 Derek Yells at Someone Apology10:23 Harvey Lampkin Joins the Show18:50 Harvey's Childhood Apology22:04 Getting in Trouble in Front of Friends 29:14 Why Dave Became a Comedian35:00 AI Song That's Good35:36 Livestreaming Across America43:00 Showtime Dancers48:35 Joblessness & The Next Wave of Hip-Hop54:50 The New Street Beef: Live Chat Wars01:01:00 Cardi B's Thoughts on Atlanta01:13:00 Viral Dog Camera Video01:20:43 OutroSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Some of Kyle Brandt's Best Cuts from the Week of 6/8/2026: Patriots AFC Favorites? Mayfield Future Seahawks still contenders Starting the #1 overall pick Trouble for Texans? Bears surprise hope Kyler Murray starting Moore for the Bills New Look Ravens 10 Takes with Kyle Brandt is part of the NFL Podcast Network See omnystudio.com/listener for privacy information.
ZXSP and DJ Moose are back together again and we have put together an amazing selection of tracks for you in this week’s episode. Most of the bands (or labels) in this episode have done something for Ukraine or are Ukrainian. Please buy music from Ukrainian artists and/or donate to your preferred Ukrainian Charity and/or to United 24 (https://u24.gov.ua). Слава Україні! Героям слава!Slava Ukrainai! Slava varoņiem!Glory to Ukraine! Glory to the Heroes! DJ Moose and ZXSP played: Intro – 00:00Shadows Hold – Haunt Me – 00:30Siluett – Apart to Start – Visitors – 03:23The Mirrors – I’ll Stay – I’ll Stay Single – 06:27distraction4ever – You Killed the Spark in Me – Life is a Laugh – 09:54 Micro with ZXSP and DJ Moose – 12:42 Morwan – Земля палає – Світає, палає – 14:30Foie Gras – Psychic Sobriety – Holy Hell EP – 18:16Glass Spells – Thrills – Shattered – 22:05Noromakina – Malva – 25:51Vioflesh – In the Depth – In the Depth Single – 29:32Destroy Me Again – Club Confession – Fill The Void – 33:01Planetdamage – Acid Case / Machine Drum Molly – KILLCAPS – 37:04Skull Cultist – Bigger Guns – HARDCORE RITUALS – 41:33 Micro with ZXSP and DJ Moose – 45:51 Ghost Cop – Trouble – Trouble – 51:07GUNSHIP – Tell Me When the World Stops Ending – Tell Me When the World Stops Ending Single – 56:36YUKO – Buvaite Zdorovi (Ambient Version) – Buvaite Zdorovi (Extended) EP – 1:00:38Ulver – Bring Out Your Dead – Sic Transit Gloria Mundi Single – 1:04:55 The original image used in this week episode is by Ukrainian Photographer by Roma Kaiuk on Unsplash or Listen to The Gothic Moose – Episode 661 – with hosts ZXSP and DJ Moose byDJ Moose on hearthis.at Here is the link to download this episode in MP3 Note: After about a year, episodes may no longer be available here or elsewhere. Shows are sometimes missing from Youtube due copyright restrictions. Use the handy built-in player:
Learn how to fix your pain with our “Centralization Process” here! https://rebrand.ly/ytpainfreeSubmit an application to work with us 1:1 and learn how to fix your low back! www.therehabfix.com/low-back-programTo view hundreds of free low back videos please follow us on instagram at @rehabfix www.instagram.com/rehabfixLow back pain is not always coming FROM your lower back… and that's exactly what I discovered after flying to Las Vegas to assess entrepreneur and podcaster Brad Lea's back pain, posture, mobility, and movement limitations.In this video, I break down the exact movement assessment he used to identify hidden mobility restrictions affecting Brad's spine health, posture, hip mobility, and overall movement quality, and show you the exercises that immediately started improving his mobility and posture FAST.If you've been dealing with:• Chronic low back pain• Tight hips and stiff lower back• Poor posture or being hunched forward• Pain when sitting too long• Hip mobility limitations• Trouble standing upright• Back stiffness when walking or lifting• Sciatica or disc-related symptoms…this video will help you understand what could REALLY be causing your pain. You'll learn:✅ Why low back pain is often a movement problem✅ How limited hip mobility can overload the lower back✅ Why posture problems are NOT always caused by weak muscles✅ The difference between spinal mobility vs hip mobility restrictions✅ How lumbar extension can improve spine health✅ Mobility exercises to improve posture and reduce stiffness✅ The hidden connection between hips, pelvis, and low back pain
Alex Byrne, Lawrence S. Rockefeller Professor of Philosophy at MIT and author of Trouble with Gender: Sex Facts, Gender Fictions (2023), argues in this conversation that the contemporary backlash against the biological definition of “woman” stems from two distinct and often conflicting intellectual currents: a longstanding feminist suspicion of biological essentialism, and a newer push, largely from trans activism, to redefine sex itself as socially constructed or non-binary. Byrne traces how this confusion has hardened into orthodoxy across academia and medicine, making dissent professionally dangerous even for scholars working from well-established science. The conversation examines the toll this has taken: researchers no-platformed, careers destroyed, and a climate in which even raising basic biological facts can trigger threats and reputational ruin. Byrne discusses MIT's Civil Discourse Project, which he co-leads, as evidence that controversial topics can still be debated productively when expectations are set honestly and both sides are willing to show up. He reflects on the reluctance of gender-affirming care's strongest proponents to defend their position in open debate, and on the growing body of evidence against pediatric medical transition. Asked whether a “truth and reconciliation” reckoning is possible, Byrne is doubtful that public admissions of error will come, but sees hope in quieter institutional change: medical bodies revising guidance, universities loosening restrictions on academic freedom, and the slow erosion of a consensus he believes is no longer defensible. Get full access to Savage Minds at www.savageminds.co/subscribe
Comedian, actor, and Emmy Award-winning writers Rosebud Baker (The Motherload, Saturday Night Live, Inside Amy Schumer) and Judy Gold (Not Suitable for Work, Life, Larry and the Pursuit of Unhappiness) join Jameela for an episode that somehow ends up on the freeway.Two women with a combined four Emmy Awards and an extensive history of catastrophic decision-making sit down to compare notes on humiliation, and it goes exactly as well as you'd expect.Judy describes the night she accidentally outed a closeted castmate while trying to be a good lesbian. Rosebud recounts the Thanksgiving she tried to rescue a sunken golf cart on her father's country club before cursing everything with the phrase "This can't get any worse." And Jameela contributes her own golf cart story, which involves the Universal lot, a freeway, and a teenage temp whose career was nearly ended.In Misery Loves Company: listener Angela takes one bong hit on her stoner roommate's advice before a job interview, and does not get the job.Follow Rosebud on Instagram and TikTok @rosebudbaker and grab her new book Fully Baked: A Messy Memoir, out now. Follow Judy on Instagram @jewdygold and get her book Yes, I Can Say That: When They Come for the Comedians, We're All in Trouble wherever books are sold. Judy is performing all summer at The Post Office Cabaret in Provincetown.Jameela's Substack is A Low Desire To Please, you can also find her on Instagram, TikTok and YouTube.Our consulting producer is Colin Anderson.Wrong Turns was created and produced by Jameela Jamil and Stewart Bailey. Hosted on Acast. See acast.com/privacy for more information.
Trouble is brewing at Outback Steakhouse, Klash With Kenzie, an update on Chicago parking meters, and more! Chicago’s best morning radio show now has a podcast! Don’t forget to rate, review, and subscribe wherever you listen to podcasts and remember that the conversation always lives on the Q101 Facebook page. Brian & Kenzie are live every morning from 6a-10a on Q101. Subscribe to our channel HERE: https://www.youtube.com/@Q101 Like Q101 on Facebook HERE: https://www.facebook.com/q101chicago Follow Q101 on Twitter HERE: https://twitter.com/Q101Chicago Follow Q101 on Instagram HERE: https://www.instagram.com/q101chicago/?hl=en Follow Q101 on TikTok HERE: https://www.tiktok.com/@q101chicago?lang=enSee omnystudio.com/listener for privacy information.
Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember
Truth.Love.Parent. with AMBrewster | Christian | Parenting | Family
It's one thing to tell our kids what's right; it's something completely different to convincingly persuade them to choose what's right for themselves. Join AMBrewster to better understand the four things we all need to do in order to be more convincing in our parenting.Truth.Love.Parent. is a podcast of Truth.Love.Family., an Evermind Ministry.Action Steps Purchase “Quit: how to stop family strife for good.” https://amzn.to/40haxLz Support our 501(c)(3) by becoming a TLP Friend! https://www.truthloveparent.com/donate.html Download the Evermind App. https://evermind.passion.io/checkout/102683 Use the promo code EVERMIND at MyPillow.com. https://www.mypillow.com/evermind Discover the following episodes by clicking the titles or navigating to the episode in your app: Why Your Kids Do What They Do https://www.truthloveparent.com/the-merest-christianity-series.html What Happens When Your Family Does What's Right in Its Own Eyes? https://www.truthloveparent.com/taking-back-the-family-blog/tlp-393-what-happens-when-your-family-does-whats-right-in-its-own-eyes How to Train Your Child to Stay with God https://www.truthloveparent.com/taking-back-the-family-blog/tlp-94-how-to-train-your-child-to-stay-with-god The Spiritual Warfare in Your Home https://www.truthloveparent.com/spiritual-warfare-in-your-home.html Biblical Parenting Essentials https://www.truthloveparent.com/biblical-parenting-essentials.html Click here for Today's episode notes, resources, and transcript: https://www.truthloveparent.com/taking-back-the-family-blog/tlp-635-how-to-convince-your-kidsLike us on Facebook: https://www.facebook.com/TruthLoveParent/Follow us on Instagram: https://www.instagram.com/truth.love.parent/Follow us on Twitter: https://twitter.com/TruthLoveParentPin us on Pinterest: https://www.pinterest.com/TruthLoveParent/Subscribe to us on YouTube: https://www.youtube.com/channel/UCTHV-6sMt4p2KVSeLD-DbcwClick here for more of our social media accounts: https://www.truthloveparent.com/presskit.htmlNeed some help? Write to us at Counselor@TruthLoveParent.com.
This week, we're heading down to New Orleans circa 1958 to revisit the soundtrack and recording sessions for the iconic musical drama "King Creole." The Dixieland aesthetic gave Elvis an opportunity experiment, melding his now-signature rock and roll style with a small jazz ensemble, creating a soundtrack LP that had a distinct sound all its own. Although few outtakes remain, the songwriter demos for nearly the entire soundtrack provide insight on how Elvis and the band further developed such classic songs as "Trouble," "Hard Headed Woman" and "Crawfish" into the final forms heard in the film. Bec also takes the opportunity chat a bit about her appreciation for the movie itself, highlighting some of her takeaways from her most recent viewing, and posing questions about the Michael Curtiz-directed film as one of Elvis' best starring roles. For Song of the Week, Justin provides a little insight on what influences may have led Elvis to experimenting at home in the mid-1960s with an early 1950s pop ballad, "My Heart Cries for You." Finally, Bec rounds out the episode with a reflection on the intimacy of the underrated "I Miss You" which was also a home recording of sorts - as it was recorded professionally by RCA in Elvis' Palm Springs home! If you enjoy TCBCast, please consider supporting us with a donation at Patreon.com/TCBCast. Your support allows us to continue to provide thoughtful, provocative, challenging and well-researched perspectives on Elvis's career, his peers and influences, and his cultural impact and legacy.
Trump just stormed off the “Meet the Press” set after going nuclear on Kristen Welker and NBC's nonstop 2020 election lies. You HAVE to see this. The moment Trump had enough of the gaslighting and walked out is pure fire — this is what fighting back against the fake news looks like. In this explosive clip, President Trump calls out NBC as a crooked, one-sided network and refuses to play NBC's rigged game any more. No more softball questions. No more pretending the 2020 election was fair. Just straight truth bombs that every conservative has been waiting for. We also cover: Spencer Pratt loses the Los Angeles mayoral race? Israel & Iran continue to shoot at each other. John Fetterman attacks “P-Hustle” s*xting scandal. AI just surpassed human traffic. Scott Pelley is the PROBLEM in journalism. If you're sick of the mainstream media's constant attacks on Trump and America First values, this video will fire you up. This isn't just another interview — it's a turning point moment that shows Trump is DONE tolerating the lies. Comment below RIGHT NOW: Was this Trump's best takedown yet? YES or NO? Should he keep going on these biased networks or ignore them completely? What was the craziest part of this interview? Drop your hottest take — I'm reading every single comment from patriots like you. 00:00 Pat Gray UNLEASHED! 00:18 New Pat Gray BINGO! Card 04:32 Iran Peace Deal Falling Apart 04:52 California in Trouble! 14:28 Out of Weapons against Iran? 16:53 Trump on U.S. Retrieving Nuclear Dust 18:16 Trump on Naval Blockade 19:21 Trump Asked Where the Leader of Iran is 21:21 Adviser to Iran's Supreme Leader on Negotiations 26:16 Price of Oil/Gas Rises Again 27:10 Trump on Treatment of J6 Protestors 34:16 Trump Walks Out of NBC Interview 37:50 Trump Asked about the New York Knicks 38:53 Enhanced Security for Madison Square Garden 41:34 Fat Five 48:59 Bots Taking Over the Internet! 53:37 John Fetterman's Thoughts on Graham Platner 1:04:47 More of John Fetterman & Graham Platner 1:06:01 Jeffy Brings Up the Tony Awards 1:06:53 Ellen DeGeneres & Portia de Rossi Return to U.S. 1:10:11 Pat Gray: The Neighborhood Gadfly 1:13:10 Interview with Scott Pelley 1:19:58 Todd Blanche's Fraud Update 1:23:13 H-1B Visa Fraud 1:28:22 Special Pat Gray UNLEASHED! Episode Later this Week 1:29:45 Debbie Dingell is Fed Up! 1:32:15 What Black People Think of Karmelo Anthony Trial Learn more about your ad choices. Visit megaphone.fm/adchoices
WHEW! The sigh of relief must be CRAZYYY! Today on the Show, HAPPY MONDAY! Johnjay was in LA this weekend what was that about? BUT FIRST, Kyle lost it and her kids are in TROUBLE! Also, we have a SECOND DATE UPDATE?? On a MONDAY? Plus, let's talk FIRST CONCERTS and TAYLOR SWIFTS SECRET WEDDING? All of this and MUCH MORE!See omnystudio.com/listener for privacy information.
AI is changing the way we work, build businesses, create wealth, and connect with people. In this episode we chat with David DeLorenzo discuss the future of AI, the economy, entrepreneurship, and the opportunities and challenges business owners face in today's rapidly changing world. Love Us? Drop us a 5-star google review HEREFree Week of my Fitness App HERE Join our Built Difference Business Community HERE Thanks to our Sponsors:AG1 CLICK HERE for a 1 year supply of vitamin D3 with free travel packs or want a FREE sample? Trouble with Sleep Try AGZ as well for free: Shoot us a DM and ask!NOBULL Electrolytes Fruit Punch HEREMy Current Fav NOBULL Kicks HEREJaylab Pro Our Protein, Turmeric, Collagen, Krill Oil https://jeremyscottfitness.jaylabpro.com/products.htmlDry Farms Wine - dryfarmwines.com/jeremyscottfitnessEach new member will earn an extra bottle for just a penny with their first order of wine when they use this link.
Massive Medicaid cuts, including new work requirements, are rolling out across the country. Trouble filing paperwork will be one reason qualifying Americans lose their coverage. In this episode, what history tells us about cutting Medicaid funding. Plus: Personal incomes are falling, consumers are prioritizing value over luxury, and we explain incoming Fed Chair Kevin Warsh's preferred inflation measure.Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.
Massive Medicaid cuts, including new work requirements, are rolling out across the country. Trouble filing paperwork will be one reason qualifying Americans lose their coverage. In this episode, what history tells us about cutting Medicaid funding. Plus: Personal incomes are falling, consumers are prioritizing value over luxury, and we explain incoming Fed Chair Kevin Warsh's preferred inflation measure.Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.
Most people measure health by the scale, body fat percentage, or what they can lift in the gym. But real health after 40 is much bigger than that.In this episode, I break down the real health scorecard: strength, conditioning, blood work, stress, relationships, finances, energy, and overall quality of life.If you're a busy adult looking to stay lean, strong, healthy, and capable for decades to come, this episode is for you.5 Week Summer Shred Challenge CLICK HERELove Us? Drop us a 5-star google review HEREJoin our Built Difference Business Community HERE Thanks to our Sponsors:AG1 CLICK HERE for a 1 year supply of vitamin D3 with free travel packs or want a FREE sample? Trouble with Sleep Try AGZ as well for free: Shoot us a DM and ask!NOBULL Electrolytes Fruit Punch HEREMy Current Fav NOBULL Kicks HEREJaylab Pro Our Protein, Turmeric, Collagen, Krill Oil https://jeremyscottfitness.jaylabpro.com/products.htmlDry Farms Wine - dryfarmwines.com/jeremyscottfitnessEach new member will earn an extra bottle for just a penny with their first order of wine when they use this link.
Trouble for Democrats in the midterms... Learn more about your ad choices. Visit megaphone.fm/adchoices