Podcasts about melanogaster

Fruit Flies, Drosophila melanogaster, are easily the best understood multicellular organism on the planet. Why do we know so much about Drosophila? Who decided to start studying this fly? And why do we keep investing time and money to fruit fly studies?Drosophila and humans share over 60% of our DNA, and about 75% of known human disease genes have a match in the DNA of fruit flies. Meaning, most human diseases can be studied using fruit flies. Drosophila is currently being used as a genetic model for Parkinson's, Alzheimer's disease, aging, oxidative stress, immunity, diabetes, and cancer, as well as drug abuse. Yes, we study all that (and a lot more) in this tiny (under 3 millimeter long) fruit fly. To look at why biologists started studying Drosophila we have to go back over 100 years ago to the Fly Room at Columbia University, and the experiments of Thomas Hunt Morgan. To see how we study Fruit Flies, you just need to look at all the Nobel Prizes awarded to scientists who made it their life's work to study with this fly. You probably studied fruit flies in biology at some point in your life, but most likely are not sure why biologists make such a big deal out of this tiny little insect. Listen now to find out why we know so much about Drosophila and why we keep studying the fruit fly. Follow us on Twitter @betterthanhuma1on Facebook @betterthanhumanpodcaston Instagram @betterthanhumanpodcasthttps://www.tiktok.com/@betterthanhumanpodcastor Email us at betterthanhumanpodcast@gmail.comWe look forward to hearing from you, and we look forward to you joining our cult of weirdness!#betterthanhuman #cultofweirdnes

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.19.390161v1?rss=1 Authors: Jonely, M., Singh, R. K., Bass, B., Noriega, R. Abstract: Drosophila melanogaster Dicer-2 is a large, multidomain protein that cleaves double-stranded RNA (dsRNA) into small interfering RNAs in a terminus-dependent manner as part of the RNA interference pathway. We characterize the local binding environment involved in this substrate-selective molecular recognition event by monitoring the time-resolved photophysics of a cyanine dye linked to the dsRNA terminus. We observe substantial changes in the molecular rigidity and local freedom of motion of the probe as a function of distinct conformations of the biomolecular complex between Dicer-2 and dsRNA as a function of dsRNA termini, the presence of regulatory proteins, and the addition of a biochemical energy source (ATP) or a non-hydrolysable equivalent (ATP-{gamma}S). With a clustering analysis based solely on these molecular-scale measures of the local binding environment at the dsRNA terminus, we identify sub-populations of similar conformations that define distinct modes of molecular recognition which are correlated with biochemical activity. These observations reveal the important role of substrate-selective molecular recognition properties for proteins with multiple domains that can bind RNA, regulatory proteins, and cofactors. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.03.232959v1?rss=1 Authors: Murgas, L., Contreras-Riquelme, S., Martinez, J. E., Villaman, C., Santibanez, R., Martin, A. J. Abstract: Motivation: The regulation of gene expression is a key factor in the development and maintenance of life in all organisms. This process is carried out mainly through the action of transcription factors (TFs), although other actors such as ncRNAs are involved. In this work, we propose a new method to construct Gene Regulatory Networks (GRNs) depicting regulatory events in a certain context for Drosophila melanogaster. Our approach is based on known relationships between epigenetics and the activity of transcription factors. Results: We developed method, Tool for Weighted Epigenomic Networks in D. melanogaster (Fly T-WEoN), which generates GRNs starting from a reference network that contains all known gene regulations in the fly. Regulations that are unlikely taking place are removed by applying a series of knowledge-based filters. Each of these filters is implemented as an independent module that considers a type of experimental evidence, including DNA methylation, chromatin accessibility, histone modifications, and gene expression. Fly T-WEoN is based on heuristic rules that reflect current knowledge on gene regulation in D. melanogaster obtained from literature. Experimental data files can be generated with several standard procedures and used solely when and if available.Fly T-WEoN is available as a Cytoscape application that permits integration with other tools, and facilitates downstream network analysis. In this work, we first demonstrate the reliability of our method to then provide a relevant application case of our tool: early development of D. melanogaster. Availability: Fly T-WEoN, together with its step-by-step guide is available at https://weon.readthedocs.io Copy rights belong to original authors. Visit the link for more info

Sie haben verschiedene Namen, aber immer ein Ziel: unser Essen und Trinken. Obst-, Essig- oder Taufliegen sind ungefährlich, aber lästig und unappetitlich. Wir erklären, wie du die Plagegeister loswirst.

Sie haben verschiedene Namen, aber immer ein Ziel: unser Essen und Trinken. Obst-, Essig-, Frucht-, Gär- oder Taufliegen sind ungefährlich, aber lästig und unappetitlich. Wir erklären, wie du die Plagegeister loswirst.

Hosts: Nels Elde and Vincent Racaniello Guest: Nitin Phadnis Nitin joins Nels and Vincent to explain how he identified a gene that is responsible for male inviability in hybrids from a cross between two species of fruit flies. Links for this episode Cell cycle regulation gene causes hybrid inviability in fruit fly (Science) Phadnis laboratory Phadnis laboratory on Facebook Gene for new species discovered (UNews) Tardigrade HGT disputed (bioRxiv) Photo credit: Lee J. Siegel, University of Utah Science Picks Nels - Watercolor of Darwin and crewVincent - SpaceX rocket landing (Verge and ArsTechnica) Nitin - 120th anniversary of Roentgen's first X-ray Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Host: Vincent Racaniello Guests: Carla Saleh and Curtis Suttle At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth. Links for this episode Greatest biodiversity on Earth (Genome) Cafeteria roenbergensis virus (PNAS) Marine viruses (Nat Rev Micro) RNAi and reverse transcription is antiviral in flies (Nat Imm) Friendly persistent infections (Curr Op Micro) RNAi and antiviral defense in Drosophila (Dev Comp Imm) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Thu, 16 May 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/16319/ https://edoc.ub.uni-muenchen.de/16319/1/Elmer_Anna_K.pdf Elmer, Anna Katharina ddc:540, ddc:500, Fakultät für Chemie und Pharmazie

00:00:00 - Julia Saltz joins the Paleopals Ryan, Patrick, Charlie and Kelly to finally figure out this genetics nonsense. The first part of the conversation focuses, as much as the show ever focuses, on Hox genes. Listen to find out why they're considered the dinosaurs of genetics. 00:24:17 - Rotten fruit isn't all bad. Sometimes Patrick drinks it, even if he admits that it sucks at first. Charlie has an Imperial IPA he wouldn't hesitate to hand to Patrick, which is saying something. Kelly keeps it practical and working class. And Ryan, per usual, keeps it weird, but with the help of Jesse Grove (who just finished his first year of law school, congrats!). 00:29:41 - Being chosen is a wonderful thing. Just ask Hal Jordan. Or ask the Paleopals what they thought of his trailer since they've chosen Green Lantern for this week's Trailer Trash Talk! 00:42:00 - Julia reappears to talk with us about how Fruit Flies fly, which is apparently like swimming. It's a confusing hodgepodge of genetics, mechanics, physics and evolution. You'd think the Paleopals would have had something intelligent to say. Maybe they did. I can't remember. It's late. 00:55:55 - PaleoPOWs are a lot like Hox genes, no one is quite sure where they came from and they're constantly mutating into different things. Kelly brings us a comment from the website about her potential travels to Norway. Charlie reads an iTunes review from SicSemperTryannosaurus (who may or may not be a dinosaur) whose review involves unicorns for some reason. Ryan reads an e-mail sent by Kate from CO about animal welfare in a lab setting based upon our talk of threats to researcher in Episode 77. She suggests the website for the Association for Assessment and Accreditation of Laboratory Animal Care International for those who want to learn more. And Patrick goes international with a Facebook comment from Manuel in Mexico. Thanks for listening! We maintain a blog. You can see if that's true at Paleocave.com Music for this week's show: Gene by Gene - Blur The Fruit That Ate Itself - Modest Mouse Sink or Swim - Deer Tick A Certain Shade of Green - Incubus

A developmental biologist studies how neurons in the fly brain find their way

A neuroscientist studies alcohol addiction in fruit flies